CN112162091B - Immune quantitative optical analysis scanning device - Google Patents
Immune quantitative optical analysis scanning device Download PDFInfo
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- CN112162091B CN112162091B CN202011169377.1A CN202011169377A CN112162091B CN 112162091 B CN112162091 B CN 112162091B CN 202011169377 A CN202011169377 A CN 202011169377A CN 112162091 B CN112162091 B CN 112162091B
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- 230000003287 optical effect Effects 0.000 title claims abstract description 88
- 238000004458 analytical method Methods 0.000 title claims abstract description 11
- 238000012360 testing method Methods 0.000 claims abstract description 48
- 230000036039 immunity Effects 0.000 claims abstract description 8
- 239000007787 solid Substances 0.000 claims description 7
- 206010070834 Sensitisation Diseases 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 230000008313 sensitization Effects 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000004445 quantitative analysis Methods 0.000 abstract description 2
- 238000001514 detection method Methods 0.000 description 5
- 238000009434 installation Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses an immunity quantitative optical analysis scanning device, which comprises a supporting frame, an optical signal processing plate, an optical scanning module and a tested piece mould frame, wherein a light emitting source and a photosensitive chip are arranged on the optical scanning module, the optical scanning module is fixedly connected with the optical signal processing plate, the photosensitive chip of the optical scanning module is fixedly arranged on the optical signal processing plate and is connected with a processing circuit on the optical signal processing plate, a silo which is transparent up and down and is sealed around is arranged on the supporting frame, the optical scanning module on the optical signal processing plate is sealed in the silo, and a drawer type tested piece conveying device is tightly arranged on the lower end surface of the silo. The structure of the immunity quantitative analysis scanning device is simplified, the occupied space is reduced, the luminous intensity is increased through focusing, the production cost is reduced, and the testing efficiency is improved.
Description
Technical Field
The invention relates to the technical field of optical scanning devices in clinical detection devices, in particular to an immunity quantitative optical analysis scanning device.
Background
Clinical detection is gradually popularized and valued in medicine due to the important characteristic of high sensitivity of optical scanning detection. However, the optical scanning device in the prior art has a complex structure, the conveying of the test piece of the substance to be detected is inconvenient, the lenses are used more in optical scanning, the distance between the lens light source and the receiving plate and the substance to be detected is larger, so that the whole loss in the detection process is overlarge, the technical procedure is complex, the accuracy and the efficiency of the test are affected, and the carrying and the use are inconvenient.
Meanwhile, the detector shell in the prior art is generally made of common ABS light polymer materials, and an optical system is extremely easy to be interfered by external electromagnetic waves in the detection process. Affecting the accuracy of the test.
Disclosure of Invention
The invention aims to provide an immunity quantitative optical analysis scanning device, which can conveniently convey a test piece to a position to be tested by using a drawer type test piece conveying structure of a substance to be tested, and has good sealing effect and no interference of external parasitic light.
In order to achieve the above object, the technical scheme of the present invention is as follows:
The utility model provides an immunity ration optical analysis scanning device, includes braced frame, optical signal processing board, optical scanning module and is tested piece mould frame, is provided with light emitting source and sensitization chip on the optical scanning module, and wherein, optical scanning module is fixed with optical signal processing board connection, and the sensitization chip of optical scanning module is fixed on optical signal processing board and is connected with the processing circuit on the optical signal processing board be provided with the silo that is transparent from top to bottom, seal all around on the braced frame, optical signal processing board is fixed in the up end of silo, and the optical scanning module on the optical signal processing board is sealed in the silo, is provided with drawer type by test piece conveyor in the lower terminal surface of silo in the hugging closely, drawer type by test piece conveyor is provided with a rectangular shape spout on the entity piece, is provided with a slide in the rectangular shape spout, by test piece mould frame setting in the slide upper surface, pushes into slide to place by test piece mould frame under the optical scanning module, after being blocked into by test piece in by test piece mould frame, is that the light-blocking space is in between optical scanning module and the test piece by test piece on the slide, and is the test piece is the light emitting source is sealed by the optical scanning, and the piece is shone by the test piece from the test piece on the test piece mould to the piece.
The scheme is further as follows: the supporting frame is a plastic product, and the outer surface of the plastic product is coated with a metal magnetic shielding layer.
The scheme is further as follows: one end of the upper surface of the sliding strip is provided with an arc concave which is used for pressing the push-pull sliding strip by a finger.
The scheme is further as follows: the upper end surfaces of the two side walls of the strip-shaped sliding groove on the solid block are provided with inward bulges, and the inward bulges clamp the sliding strip to slide forwards and backwards only.
The scheme is further as follows: the bottom end surface of the strip-shaped sliding groove is provided with an upward elastic bulge serving as a clamp spring, the upward elastic bulge is in a circular arc shape or is provided with an upward elastic bulge with a slope surface in the front-back direction, the bottom end surface of the sliding strip is provided with a clamping groove corresponding to the elastic bulge, and the clamp spring of the upward elastic bulge is used for positioning a die frame of a tested piece to be arranged below the optical scanning module.
The scheme is further as follows: the upward elastic protrusions are arranged at intervals along the front and back of the strip-shaped sliding groove.
The scheme is further as follows: the optical scanning module comprises a plastic frame die, the plastic frame die is fixed on an optical signal processing plate, a light-emitting source clamping groove and a light-sensitive chip clamping groove are formed in the plastic frame die, a light-emitting source and a light-sensitive chip are respectively clamped in the light-emitting source clamping groove and the light-sensitive chip clamping groove, a condensing lens piece is arranged right in front of the light-sensitive chip clamping groove, a condensing lens piece is clamped in the condensing lens piece clamping groove, the condensing lens piece faces a tested piece die frame, an axis of the light-emitting source, which irradiates light to a tested piece clamped in the tested piece die frame, forms an included angle of 45 degrees with an axis of the light-sensitive chip, which irradiates light to the condensing lens piece, a first aperture diaphragm clamping groove and a second aperture diaphragm clamping groove are sequentially arranged on the plastic frame die forward from the light-emitting source, a first aperture diaphragm card and a second aperture diaphragm card are respectively clamped in, strip-shaped light-transmitting holes are respectively formed in the first aperture diaphragm card and the second aperture diaphragm card, and the light-emitting light passes through strip-shaped light-transmitting holes on the first aperture diaphragm card and the second aperture card, and the light-sensitive chip irradiates the strip-shaped light-emitting light to the tested piece.
The scheme is further as follows: the distance from the photosensitive chip to the condensing lens sheet is 8.5mm, the distance from the condensing lens sheet to the tested sheet is 8.5mm, the distance from the light-emitting source to the first aperture diaphragm card is 1.55mm, the distance from the first aperture diaphragm card to the second aperture diaphragm card is 7.26mm, and the distance from the second aperture diaphragm card to the tested sheet is 8.1mm.
The scheme is further as follows: the strip-shaped light holes are strip-shaped holes with the width of 1mm and the length of 4 mm.
The scheme is further as follows: the condensing lens sheet is a 1.5-fold focusing lens sheet.
The beneficial effects of the invention are as follows: the drawer type substance test piece conveying structure can conveniently convey the test piece to the position to be tested, and the sealing effect is good and is not interfered by external stray light.
The optical fixing module is provided with the fixing clamping groove for fixing the optical piece on the plastic frame die, so that the installation procedure is simplified, meanwhile, the replacement of lenses with different specifications is also facilitated, meanwhile, the position and focusing are not required to be checked again, the structure is simple, the operation is convenient, and the installation difficulty of each part of the optical system is simplified.
The use of rectangular shape light trap has reduced the use of diaphragm card, has solved prior art for the complicated structural design of acquisition information, loss too big, use inconvenient, higher problem of manufacturing cost. The device simplifies the structure of the immunity quantitative analysis scanning device, reduces the occupied space, increases the luminous intensity through focusing, reduces the production cost, improves the test efficiency, and is convenient to move and use. Meanwhile, the support shell with the metal coating effectively prevents the influence of external electromagnetic waves on an optical system, and improves the accuracy of testing.
The invention is described in detail below with reference to the drawings and examples.
Drawings
FIG. 1 is a schematic view of an exploded construction of the present invention;
FIG. 2 is a schematic illustration of the assembled structure of the present invention;
FIG. 3 is a schematic diagram of the structure of a clamp spring at the end face of the long-strip-shaped slide groove bottom;
FIG. 4 is a schematic diagram of an optical scanning of the present invention;
FIG. 5 is a schematic view of a plastic frame mold structure of an optical scanning module according to the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present embodiment, it should be noted that the terms "connected" and "disposed" should be interpreted broadly, for example, "connected" may be a wire connection or a mechanical connection; the 'placement' can be fixed connection placement or integrated placement. The specific meaning of the above terms in the present embodiment can be understood by those of ordinary skill in the art according to the specific circumstances.
An immunity quantitative optical analysis scanning device is shown in fig. 1 and 2, and comprises a supporting frame 1, an optical signal processing board 2, an optical scanning module 3 and a tested piece mould frame 4; the supporting frame 1 is a plastic product, and a metal magnetic shielding layer is coated on the outer surface of the plastic product in order to reduce magnetic interference of surrounding environment. The optical signal processing board 2 is provided with a tube signal processing circuit, the processed signal is led out through the interface socket 201, the support frame 1 is connected and fixed with the base 5 on the base 5, fig. 4 illustrates an optical scanning principle, the optical scanning module comprises a light emitting source 301, a photosensitive chip 302, a condensing lens sheet 303, a first aperture diaphragm card 304 and a second aperture diaphragm card 305, the linear front end of the photosensitive chip 302 is provided with the condensing lens sheet 303, the straight surface of the condensing lens sheet is irradiated to the tested sheet 7 in the tested sheet mold frame 4 by the tested sheet 7, the light emitted by the light emitting source 301 is focused by the first aperture diaphragm card 304 and the second aperture diaphragm card 305 and then is sent to the photosensitive chip, and the reflected light of the tested sheet 7 is received and returned from the tested sheet mold frame, wherein: the axis of the light emitted by the light-emitting source and the axis of the light-sensitive chip to the condensing lens sheet form an angle of 45 degrees and irradiate onto a tested piece clamped in the tested piece mold frame. The distance from the photosensitive chip to the condensing lens sheet is 8.5mm, the distance from the condensing lens sheet to the tested sheet is 8.5mm, the distance from the light-emitting source to the first aperture diaphragm card is 1.55mm, the distance from the first aperture diaphragm card to the second aperture diaphragm card is 7.26mm, and the distance from the second aperture diaphragm card to the tested sheet is 8.1mm.
The optical scanning module 3 is fixedly connected with the optical signal processing board 2, the photosensitive chip 302 of the optical scanning module is fixedly connected with a processing circuit on the optical signal processing board 2, a silo 101 which is transparent from top to bottom and is sealed around is arranged on the supporting frame, the optical signal processing board is fixedly arranged on the upper end face of the silo, the optical scanning module 3 on the optical signal processing board 2 is sealed in the silo 101, a drawer-type tested piece conveying device 6 is closely arranged on the lower end face of the silo, the drawer-type tested piece conveying device comprises a solid block 601, a strip-shaped chute 602 is arranged on the solid block, a slide 603 is arranged in the strip-shaped chute, a tested piece die frame 4 is arranged on the upper surface of the slide, one end of the upper surface of the slide is provided with an arc concave 603-1, the arc concave is used for pressing the push-pull strip by fingers, the upper end faces of the two side walls of the strip-shaped chute on the solid block are provided with inward protrusions 604, the slide limiting card can slide in the strip-shaped chute 602 to slide back and forth in the strip-shaped chute 602, the drawer-shaped chute slides in the front of the strip-shaped chute, the drawer-shaped chute is pushed into the test piece 603, the light-receiving optical card is arranged in the test piece 7, the light-reflecting plate 3 is arranged between the test piece and the optical module is arranged in the test piece, and the test piece 3, and the test piece is arranged in the test piece, and the test piece is a test piece and the test piece is completely reflected by the test piece and is completely and the sealed.
In order to accurately position the die frame of the tested piece below the optical scanning module 3, the length of the long strip-shaped chute 602 can be limited to position, and the slide bar is pushed to the head and positioned, but in the embodiment, a clamp spring positioning structure is adopted, namely: an upward elastic bulge 605 serving as a clamp spring is arranged on the bottom end surface of the strip-shaped chute, and two upward elastic bulges 605 are arranged at intervals along the front and back of the strip-shaped chute; in addition, in order to facilitate the entry and exit of the clamp spring, as shown in fig. 3, the upward elastic protrusion is an upward elastic protrusion with a circular arc shape or a front-back slope, in this embodiment, the upward elastic protrusion with a front-back slope is provided, a clamping groove 603-2 corresponding to the elastic protrusion is provided on the bottom end surface of the slide 603, the clamping groove 603-2 in this embodiment is a through hole, and the clamp spring with the upward elastic protrusion is used for positioning the tested piece mold frame under the optical scanning module.
In order to facilitate the installation of the clamping position, it is shown in fig. 5: the optical scanning module comprises a plastic frame mould 8 which is inserted and fixed on an optical signal processing board 2 through a shaft pin 801, a luminous source clamping groove 802 and a photosensitive chip clamping groove 803 are arranged on the plastic frame mould, a luminous source 301 and a photosensitive chip 302 are respectively clamped into the luminous source clamping groove and the photosensitive chip clamping groove, a condensing lens clamping groove 804 is arranged right in front of the photosensitive chip clamping groove, a condensing lens 303 is clamped into the condensing lens clamping groove, the condensing lens faces to a tested sheet mould frame, an included angle a is formed between the axis of the luminous source, which irradiates light to a tested sheet clamped in the tested sheet mould frame, and the axis of the photosensitive chip to the condensing lens, the first aperture diaphragm clamping groove 805 and the second aperture diaphragm clamping groove 806 are sequentially arranged on the plastic frame die from the light-emitting source forwards, the first aperture diaphragm clamping groove and the second aperture diaphragm clamping groove are respectively clamped in the first aperture diaphragm card 304 and the second aperture diaphragm card 305, for obtaining more light information, narrow slit long strip-shaped light transmission holes are respectively formed in the first aperture diaphragm card 304 and the second aperture diaphragm card 305, light emitted by the light-emitting source passes through the long strip-shaped light transmission holes in the first aperture diaphragm card and the second aperture diaphragm card to be irradiated on a tested piece in a long strip-shaped light beam mode, and the light-focusing lens piece focuses the long strip-shaped light beam reflected on the tested piece to a photosensitive chip, and the light-focusing lens piece is 1.5 times of the focusing lens piece. The strip-shaped light holes on the first aperture diaphragm card and the second aperture diaphragm card are identical in width, namely, the strip-shaped holes with the height of 1mm and the length of 4 mm. The plastic frame mold 8 lens component framework simplifies the installation and debugging of each lens in the optical system, reduces the occupied space of the optical system in the prior art, simultaneously facilitates the replacement of lenses with different specifications, simultaneously does not need to check the position and focus again, increases the luminous intensity through focusing, avoids the complex design of an optical path and the loss of energy in the process, reduces the production cost, has a simple structure and convenient operation, simplifies the installation difficulty of each component of the optical system, and improves the test efficiency.
Claims (8)
1. The utility model provides an immunity quantitative optical analysis scanning device, including braced frame, optical signal processing board, optical scanning module and by test piece mould frame, be provided with light emitting source and sensitization chip on the optical scanning module, characterized by that, optical scanning module is fixed with optical signal processing board connection, and the sensitization chip of optical scanning module is fixed on optical signal processing board and is connected with the processing circuit on the optical signal processing board, is provided with the silo that passes through from top to bottom, the sealed all around on the braced frame, optical signal processing board is fixed in the up end of silo, and the optical scanning module on the optical signal processing board is sealed in the silo, is provided with drawer type by test piece conveyor in the lower terminal surface of silo hugging closely, drawer type by test piece conveyor is including a solid piece, is provided with an rectangular shape spout on the solid piece, is provided with a draw-bar in the rectangular shape spout, by test piece mould frame sets up on the draw-bar, pushes into draw-bar and places by test piece mould frame under optical scanning module, after being blocked into by test piece in by test piece mould frame, is the light emitting source total reflection test piece from the test piece of optical scanning module to the test piece on the draw-bar, the test piece is reflected light from the test piece;
The optical scanning module comprises a plastic frame die, the plastic frame die is fixed on an optical signal processing plate, a light-emitting source clamping groove and a light-sensing chip clamping groove are formed in the plastic frame die, a light-emitting source and a light-sensing chip are respectively clamped in the light-emitting source clamping groove and the light-sensing chip clamping groove, a light-gathering lens plate clamping groove is formed in the right front of the light-sensing chip clamping groove, a light-gathering lens plate is clamped in the light-gathering lens plate clamping groove, the light-gathering lens plate faces a die frame of a tested piece, an axis of the light-emitting source, which irradiates light to the tested piece clamped in the die frame of the tested piece, forms an included angle of 45 degrees with an axis of the light-sensing chip and the light-gathering lens plate, a first aperture diaphragm clamping groove and a second aperture diaphragm clamping groove are sequentially formed in the plastic frame die from the light-emitting source, a first aperture diaphragm card and a second aperture diaphragm card are respectively clamped in the first aperture diaphragm card and the second aperture card, strip-shaped light holes are respectively formed in the first aperture diaphragm card and the second aperture card, the light-gathering lens plate irradiates the tested piece in a strip-shaped shape through the strip-shaped light-gathering lens plate, and the light-gathering lens plate irradiates the light beam to the tested piece in a strip-shaped shape;
The supporting frame is a plastic product, and the outer surface of the plastic product is coated with a metal magnetic shielding layer.
2. The immunoquantitative optical analysis scanning apparatus of claim 1, wherein one end of the upper surface of the slide is provided with a circular arc depression for finger holding the push-pull slide.
3. The device according to claim 1, wherein the upper end surfaces of the two side walls of the elongated chute on the solid block are provided with inward protrusions, and the inward protrusions clamp the slide bar to slide back and forth only.
4. The immune quantitative optical analysis scanning device according to claim 1 or 3, wherein an upward elastic bulge serving as a clamp spring is arranged on the bottom end surface of the long-strip-shaped chute, the upward elastic bulge is in a circular arc shape or is provided with upward elastic bulges with slopes in front and back, a clamping groove corresponding to the elastic bulge is arranged on the bottom end surface of the sliding strip, and the clamp spring of the upward elastic bulge is used for positioning a tested piece die frame to be placed under the optical scanning module.
5. The apparatus of claim 4, wherein two upward elastic protrusions are disposed at intervals along the elongated chute.
6. The apparatus according to claim 1, wherein the distance from the photosensitive chip to the condensing lens sheet is 8.5mm, the distance from the condensing lens sheet to the test piece is 8.5mm, the distance from the light source to the first aperture stop card is 1.55mm, the distance from the first aperture stop card to the second aperture stop card is 7.26mm, and the distance from the second aperture stop card to the test piece is 8.1mm.
7. The immunoassay optical assay scanner of claim 1 or 6, wherein the elongated light-transmitting well is an elongated well having a width of 1mm and a length of 4 mm.
8. The immunoquantitative optical analysis scanning apparatus of claim 6, wherein said condensing lens sheet is a 1.5-fold focusing lens sheet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011169377.1A CN112162091B (en) | 2020-10-28 | 2020-10-28 | Immune quantitative optical analysis scanning device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011169377.1A CN112162091B (en) | 2020-10-28 | 2020-10-28 | Immune quantitative optical analysis scanning device |
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| Publication Number | Publication Date |
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| CN112162091A CN112162091A (en) | 2021-01-01 |
| CN112162091B true CN112162091B (en) | 2024-08-02 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN213482256U (en) * | 2020-10-28 | 2021-06-18 | 普迈德（北京）科技有限公司 | Immune quantitative optical analysis scanning device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7173705B2 (en) * | 2003-02-26 | 2007-02-06 | Hamamatsu Photonics K.K. | Measuring device for immunochromatography test piece |
| CA2769380C (en) * | 2009-07-27 | 2020-08-25 | Meso Scale Technologies, Llc | Assay apparatuses, consumables and methods |
| CN104115478B (en) * | 2011-12-16 | 2016-04-20 | 利-考股份有限公司 | luminescence imaging scanner |
| CN106324237B (en) * | 2016-08-18 | 2018-03-06 | 北京乐普医疗科技有限责任公司 | A kind of fluorescence immunoassay quantitative analysis scanning means |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN213482256U (en) * | 2020-10-28 | 2021-06-18 | 普迈德（北京）科技有限公司 | Immune quantitative optical analysis scanning device |
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