CN111686008A - Mixed-decocting traditional Chinese medicine phosphorus removal process - Google Patents
Mixed-decocting traditional Chinese medicine phosphorus removal process Download PDFInfo
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Abstract
The invention relates to the technical field of pharmacy, and particularly discloses a mixed-decocting traditional Chinese medicine dephosphorizing process which comprises the following steps: s1 dephosphorization: weighing and mixing the medicinal materials in the decoction-mixing prescription, adding water, heating to 55-65 ℃, then adjusting the pH value to acidity, then adding lanthanum carbonate, adding 1-3g of lanthanum carbonate into every 500ml of water, and continuously stirring for 1-3h after adding the lanthanum carbonate to obtain a soaked substance; s2 filtering: removing lanthanum salt precipitate in the soaked substance to obtain a filtrate; s3 extraction: extracting the filtrate to obtain the mixed-decocted traditional Chinese medicine. The mixed-decocted traditional Chinese medicine is treated in advance, lanthanum ions and phosphate radicals are combined to form insoluble compounds, and the phosphorus content in the mixed-decocted traditional Chinese medicine is further reduced, so that the mixed-decocted traditional Chinese medicine is suitable for patients with renal insufficiency.
Description
Technical Field
The invention relates to the field of pharmaceutical technology, in particular to a dephosphorization process for a mixed-decocting traditional Chinese medicine.
Background
Renal insufficiency, i.e., severe destruction of the glomerulus, causes the body to develop a clinical syndrome with disorders in the excretion of metabolic waste, regulation of water electrolyte, acid-base balance, and the like. In the patients, the phosphorus removal function is affected to different degrees, so that the phosphorus generated by self metabolism is difficult to be discharged out of the body, and the blood phosphorus is increased. The patients should pay attention to high calcium and low phosphorus in diet, and the selection of the traditional Chinese medicine should pay attention to the content of calcium and phosphorus.
At present, low-phosphorus traditional Chinese medicines are used for treating patients with renal insufficiency, and the traditional Chinese medicines belong to a common modern treatment means. The traditional Chinese medicines such as the curculigo orchioides, the magnolia officinalis and the like have low phosphorus content and high calcium content, and are suitable for patients with renal insufficiency; however, the traditional Chinese medicines such as coptis root and ligusticum chuanxiong hort have high phosphorus content and are not suitable for patients with renal insufficiency.
It is not known that any traditional Chinese medicine is suitable for patients with renal insufficiency, and the requirement for difficulty in treatment schemes is increased, and improvement is needed.
Disclosure of Invention
Aiming at the problem that the high-phosphorus traditional Chinese medicine in the prior art is not suitable for patients with renal insufficiency, the invention aims to provide a mixed-decocting traditional Chinese medicine phosphorus removal process which has the advantage of reducing the phosphorus content in the traditional Chinese medicine.
In order to achieve the purpose, the invention provides the following technical scheme:
a mixed decocting traditional Chinese medicine dephosphorization process comprises the following steps:
s1 dephosphorization: weighing and mixing the medicinal materials in the decoction-mixing prescription, adding water, heating to 55-65 ℃, then adjusting the pH value to acidity, then adding lanthanum carbonate, adding 1-3g of lanthanum carbonate into every 500ml of water, and continuously stirring for 1-3h after adding the lanthanum carbonate to obtain a soaked substance;
s2 filtering: removing lanthanum salt precipitate in the soaked substance to obtain a filtrate;
s3 extraction: extracting the filtrate to obtain the mixed-decocted traditional Chinese medicine.
By adopting the technical scheme, partial phosphorus in the traditional Chinese medicine is removed by adopting the chemical adsorption principle. Lanthanum ions and phosphate radical are combined to form a indissolvable compound, so that the phosphorus content in the mixed-decocted traditional Chinese medicine is reduced. The valence state of lanthanum is stable, and the lanthanum is combined with phosphorus and cannot be released again due to oxidation-reduction reaction.
The traditional Chinese medicine for mixed decoction is treated in advance to reduce the phosphorus content, is suitable for patients with renal insufficiency, and the prescription for mixed decoction is not limited by the traditional Chinese medicine with high phosphorus. Compared with the mode of directly taking lanthanum carbonate, the pretreatment mode has the following advantages: 1. the side effect of the lanthanum carbonate on human bodies can not be generated, and the safety is high; 2. lanthanum carbonate does not have adverse effect on the action of other medicaments; 3. the patient can directly take the traditional Chinese medicine preparation, which is convenient and does not cause troubles due to forgetting to take lanthanum carbonate; 4. the cost is reduced.
Further, in the phosphorus removal of S1, the total water adding mass is equal to the total mass of the medicinal materials.
Further, in the phosphorus removal of S1, the pH is adjusted to 3-4 by using dilute hydrochloric acid.
By adopting the technical scheme, the lanthanum carbonate is easy to dissociate in the pH value range, lanthanum ions are combined with phosphate radicals to form a indissolvable compound, and the phosphorus removal effect is good.
Further, the specific process of the S2 filtering is as follows: filtering the soaked substance to obtain medicinal material and primary filtrate, washing the medicinal material with water for 2-4 times to obtain washing liquid, filtering the washing liquid to obtain secondary filtrate, and mixing the primary filtrate, the secondary filtrate and the washed medicinal material to obtain filtrate.
By adopting the technical scheme, the lanthanum phosphate precipitate and the unreacted lanthanum carbonate precipitate in the soaked substances are removed by filtration.
Further, the specific process of S3 extraction is as follows: heating the filtrate to 100-.
By adopting the technical scheme, the effective substances in the medicinal materials are fully extracted.
Further, step S4 of concentrating is also included, and the specific process is as follows: heating the mixed decocted traditional Chinese medicine to 110 ℃ and concentrating to the density of 1.3-1.4g/ml to obtain concentrated solution.
Further, step S5 of granulating the concentrated solution to obtain granular medicine.
By adopting the technical scheme, the Chinese medicinal preparation can be concentrated solution or granular, and is suitable for different prescriptions.
In conclusion, the invention has the following beneficial effects: the invention adopts lanthanum carbonate to reduce the phosphorus content in the traditional Chinese medicine, so that the mixed-decocting traditional Chinese medicine is suitable for patients with renal insufficiency, and the mixed-decocting prescription is not limited by the high-phosphorus traditional Chinese medicine.
Detailed Description
The present invention is further illustrated in detail by the following examples, in which: the following examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer, and the starting materials used in the following examples are available from ordinary commercial sources unless otherwise specified.
The embodiment of the invention adopts the following mixed decoction formula: 30g of radix astragali (raw), 10g of radix-polygoni multiflori (prepared), 15g of poria cocos, 10g of talcum powder, 20g of radix salviae miltiorrhizae, 10g of fructus psoraleae, 10g of semen plantaginis (fried), 10g of cortex moutan radicis, 10g of madder, 10g of codonopsis pilosula, 10g of rhizoma atractylodis macrocephalae (fried), 6g of liquorice (roasted), 10g of rhizoma alismatis, 15g of herba epimedii, 15g of semen cuscutae, 10g of radix paeoniae rubra, 15g of rhizoma imperatae and 9.
Example 1:
a mixed decocting traditional Chinese medicine dephosphorization process comprises the following steps:
s1 dephosphorization: weighing the medicinal materials in the mixed decoction formula, mixing to obtain 225g of mixed medicinal materials, adding 225ml of purified water, heating to 60 ℃, adjusting the pH to 3.5 by using 0.1mol/L dilute hydrochloric acid, adding 0.9g of lanthanum carbonate, and continuously stirring for 2h to obtain a soaked substance;
s2 filtering: filtering the soaked substance with 160 mesh screen to obtain medicinal material and primary filtrate, placing the medicinal material on 14 mesh screen, washing with purified water for 3 times to obtain washing liquid, filtering the washing liquid with 160 mesh screen to obtain secondary filtrate, and mixing the primary filtrate, the secondary filtrate and the medicinal material to obtain filtrate;
s3 extraction: heating the filtrate to 105 deg.C, stirring, standing for 1 hr, filtering to remove medicinal materials to obtain mixed decoction Chinese medicinal materials;
s4 concentration: heating the mixed decocted traditional Chinese medicine to 105 ℃, and concentrating to obtain a concentrated solution with the density of 1.3 g/ml;
s5 granulating: drying the concentrated solution to obtain dry extract, and granulating to obtain granule.
Example 2:
a mixed decocting traditional Chinese medicine dephosphorization process comprises the following steps:
s1 dephosphorization: weighing the medicinal materials in the mixed decoction formula, mixing to obtain 225g of mixed medicinal materials, adding 225ml of purified water, heating to 55 ℃, adjusting the pH to 3 by using 0.1mol/L dilute hydrochloric acid, adding 1.35g of lanthanum carbonate, and continuously stirring for 1h to obtain a soaked substance;
s2 filtering: filtering the soaked substance with 160 mesh screen to obtain medicinal material and primary filtrate, placing the medicinal material on 14 mesh screen, washing with purified water for 2 times to obtain washing liquid, filtering the washing liquid with 160 mesh screen to obtain secondary filtrate, and mixing the primary filtrate, the secondary filtrate and the medicinal material to obtain filtrate;
s3 extraction: heating the filtrate to 100 deg.C, stirring, standing for 1.5 hr, filtering to remove medicinal materials to obtain mixed decoction Chinese medicine;
s4 concentration: heating the mixed decocted traditional Chinese medicine to 100 ℃, and concentrating to the density of 1.35g/ml to obtain concentrated solution;
s5 granulating: drying the concentrated solution to obtain dry extract, and granulating to obtain granule.
Example 3:
a mixed decocting traditional Chinese medicine dephosphorization process comprises the following steps:
s1 dephosphorization: weighing the medicinal materials in the mixed decoction formula, mixing to obtain 225g of mixed medicinal materials, adding 225ml of purified water, heating to 65 ℃, adjusting the pH to 4 by using 0.1mol/L dilute hydrochloric acid, adding 0.45g of lanthanum carbonate, and continuously stirring for 3h to obtain a soaked substance;
s2 filtering: filtering the soaked substance with 160 mesh screen to obtain medicinal material and primary filtrate, placing the medicinal material on 14 mesh screen, washing with purified water for 4 times to obtain washing liquid, filtering the washing liquid with 160 mesh screen to obtain secondary filtrate, and mixing the primary filtrate, the secondary filtrate and the medicinal material to obtain filtrate;
s3 extraction: heating the filtrate to 100 deg.C, stirring, standing for 1.5 hr, filtering to remove medicinal materials to obtain mixed decoction Chinese medicine;
s4 concentration: heating the mixed decocted traditional Chinese medicine to 110 ℃, and concentrating to the density of 1.4g/ml to obtain concentrated solution;
s5 granulating: drying the concentrated solution to obtain dry extract, and granulating to obtain granule.
Example 4:
the difference from example 1 is that the pH is adjusted to 5 with dilute hydrochloric acid.
Example 5:
the difference from example 1 is that the pH is adjusted to 2 with dilute hydrochloric acid.
Comparative example 1;
the difference from example 1 is that lanthanum carbonate is not added.
Phosphorus removal test:
the test process refers to the method recorded in the four parts 3109 of the year edition of the Chinese pharmacopoeia 2015, and comprises the following specific processes:
preparing materials:
15% sulfuric acid solution: weighing 15ml of sulfuric acid, slowly adding the sulfuric acid into 80ml of water, cooling, diluting with water to 100ml, and uniformly mixing;
0.04mol/L ammonium molybdate solution: weighing 5g of ammonium molybdate (tetrahydrate), adding a 15% sulfuric acid solution for dissolving and diluting to 100 ml;
hydroquinone solution: weighing 0.5g of hydroquinone, adding 100mL of water for dissolving, and adding a drop of concentrated sulfuric acid after dissolving;
20% sodium sulfite solution: weighing 20g of anhydrous sodium sulfite, adding 100mL of water for dissolving, and preparing the sodium sulfite for use temporarily;
phosphorus stock solution (760.2 mM) (phosphorus concentration: 23.54 mg/ml): weighing 10.346g of monopotassium phosphate, precisely weighing, placing in a 100ml measuring flask, dissolving with water and diluting to scale;
phosphorus standard use solution (phosphorus concentration: 0.024 mg/ml): precisely measuring 1ml of phosphorus stock solution, placing the phosphorus stock solution in a 50ml measuring flask, adding water to dilute the phosphorus stock solution to a scale, precisely measuring 1ml of the diluted phosphorus stock solution, placing the phosphorus stock solution in a 20ml measuring flask, and adding water to dilute the phosphorus stock solution to the scale;
test solution preparation: respectively measuring the concentrated solutions of examples 1-5 and comparative example 1, diluting with water by 125 times, measuring 5ml of diluted concentrated solution, filtering with 0.45 μm filter membrane, precisely measuring 1ml of filtrate, placing in a 10ml measuring flask, and adding water to dilute to scale to obtain test solution;
secondly, drawing a phosphorus standard curve:
precisely measuring 0ml, 0.5 ml, 1ml, 2ml, 3 ml, 4 ml and 5ml of phosphorus standard use solution, respectively placing into 25ml measuring bottles (phosphorus concentration: 0.47ug/ml-4.7 ug/ml), adding 2ml of ammonium molybdate solution, and shaking uniformly; adding 1ml of sodium sulfite solution and 1ml of hydroquinone solution, adding water to dilute the solution to a scale, shaking the solution uniformly to be used as phosphorus standard solution with various concentrations, standing the solution at room temperature for 30 minutes, measuring the absorbance of the solution at the wavelength of 660nm, and drawing a standard curve by using the absorbance and the concentration of the phosphorus standard solution;
(III) detection of test solution:
2ml of the test solution prepared in the embodiments 1 to 5 and the comparative example 1 is weighed and placed in a 25ml measuring flask, 2ml of 0.04mol/L ammonium molybdate solution is added, the mixture is uniformly mixed, 1ml of sodium sulfite solution and 1ml of hydroquinone solution are added, water is added for dilution to the scales, the mixture is shaken uniformly, the mixture is placed at room temperature for 30 minutes, the absorbance is measured at the position with the wavelength of 660nm by an ultraviolet-visible spectrophotometry method, meanwhile, a blank solution prepared by the same method is calibrated to zero, and the content of phosphorus ions in the test solution can be read, and the result is shown in Table 1.
TABLE 1 test results of phosphorus ion content
| Phosphorus content (ppm) | |
| Example 1 | 154 |
| Example 2 | 162 |
| Example 3 | 171 |
| Example 4 | 241 |
| Example 5 | 286 |
| Comparative example 1 | 1052 |
From the results of table 1, it can be seen that:
1. comparing the results of example 1 and comparative example 1, the present invention has excellent dephosphorizing effect;
2. comparison of the results of examples 1-3 shows that example 1 has the lowest phosphorus content, which is the preferred example;
3. results of examples 1, 4, and 5 comparative examples show that lanthanum carbonate in the pH range of example 1 preferably performs the phosphorus removal function.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Claims (7)
1. The mixed decocting traditional Chinese medicine phosphorus removal process is characterized by comprising the following steps:
s1 dephosphorization: weighing and mixing the medicinal materials in the decoction-mixing prescription, adding water, heating to 55-65 ℃, then adjusting the pH value to acidity, then adding lanthanum carbonate, adding 1-3g of lanthanum carbonate into every 500ml of water, and continuously stirring for 1-3h after adding the lanthanum carbonate to obtain a soaked substance;
s2 filtering: removing lanthanum salt precipitate in the soaked substance to obtain a filtrate;
s3 extraction: extracting the filtrate to obtain the mixed-decocted traditional Chinese medicine.
2. The dephosphorization process for the mix-fried traditional Chinese medicine according to claim 1, which is characterized in that: in the phosphorus removal of the S1, the total water adding mass is equal to the total mass of the medicinal materials.
3. The dephosphorization process for the mix-fried traditional Chinese medicine according to claim 1, which is characterized in that: in the phosphorus removal of S1, the pH is adjusted to 3-4 by dilute hydrochloric acid.
4. The dephosphorization process for the mix-fried traditional Chinese medicine according to claim 1, which is characterized in that: the specific process of the S2 filtering is as follows: filtering the soaked substance to obtain medicinal material and primary filtrate, washing the medicinal material with water for 2-4 times to obtain washing liquid, filtering the washing liquid to obtain secondary filtrate, and mixing the primary filtrate, the secondary filtrate and the washed medicinal material to obtain filtrate.
5. The dephosphorization process for the mix-fried traditional Chinese medicine according to claim 1, which is characterized in that: the specific process of S3 extraction is as follows: heating the filtrate to 100-.
6. The dephosphorization process for the mix-fried traditional Chinese medicine according to claim 5, which is characterized in that: further comprises a step S4 of concentration, which comprises the following specific processes: heating the mixed decocted traditional Chinese medicine to 110 ℃ and concentrating to the density of 1.3-1.4g/ml to obtain concentrated solution.
7. The dephosphorizing process of the mix-decocted traditional Chinese medicine according to claim 6, which is characterized in that: the method also comprises a step S5 of granulating the concentrated solution to prepare granular medicament.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3956118A (en) * | 1968-05-23 | 1976-05-11 | Rockwell International Corporation | Removal of phosphate from waste water |
| CN101304753A (en) * | 2005-11-09 | 2008-11-12 | 夏尔国际许可有限公司 | Treatment of chronic kidney disease (CKD) subjects using lanthanum compounds |
| CN104324201A (en) * | 2014-11-18 | 2015-02-04 | 郝建友 | Traditional Chinese medicine preparation for treating urinary system infection and production method |
| CN104876639A (en) * | 2015-05-13 | 2015-09-02 | 安徽建筑大学 | Porous phosphorus removal ceramisites and preparation method thereof |
| CN106177250A (en) * | 2016-08-29 | 2016-12-07 | 长沙佰顺生物科技有限公司 | A kind of Chinese medicine composition treating chronic nephritis |
| CN106237014A (en) * | 2016-08-29 | 2016-12-21 | 长沙佰顺生物科技有限公司 | A kind of Chinese medicine composition treating chronic nephritis |
-
2020
- 2020-07-20 CN CN202010697204.0A patent/CN111686008A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3956118A (en) * | 1968-05-23 | 1976-05-11 | Rockwell International Corporation | Removal of phosphate from waste water |
| CN101304753A (en) * | 2005-11-09 | 2008-11-12 | 夏尔国际许可有限公司 | Treatment of chronic kidney disease (CKD) subjects using lanthanum compounds |
| CN104324201A (en) * | 2014-11-18 | 2015-02-04 | 郝建友 | Traditional Chinese medicine preparation for treating urinary system infection and production method |
| CN104876639A (en) * | 2015-05-13 | 2015-09-02 | 安徽建筑大学 | Porous phosphorus removal ceramisites and preparation method thereof |
| CN106177250A (en) * | 2016-08-29 | 2016-12-07 | 长沙佰顺生物科技有限公司 | A kind of Chinese medicine composition treating chronic nephritis |
| CN106237014A (en) * | 2016-08-29 | 2016-12-21 | 长沙佰顺生物科技有限公司 | A kind of Chinese medicine composition treating chronic nephritis |
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