CN110478621A - A kind of programmable neuromagnetic stimulation device - Google Patents
A kind of programmable neuromagnetic stimulation device Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/12—Magnetotherapy using variable magnetic fields obtained by mechanical movement
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
- G05B19/042—Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors
- G05B19/0423—Input/output
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Abstract
The invention discloses a kind of programmable neuromagnetic stimulation devices, the rotating magnetic field generator including pedestal and setting on the base；The driving device that rotating magnetic field generator includes magnetic head, is connected with magnetic head and magnetic head is driven to rotate, driving device are connected with single-chip microcontroller, and single-chip microcontroller controls magnetic field generator and generates rotating excitation field, the cyclically-varying at any time of the magnetic field strength of the rotating excitation field.The present invention regulates and controls field frequency using the Motor Rotating Speed Control System based on single-chip microcontroller encoder, and it is applied to neuromagnetic stimulation field, realizes the programmable neuromagnetic stimulation rhythm and pace of moving things, can be used for the related science research of neuromagnetic stimulation effect.By the specific magnetic fields rhythm and pace of moving things, in conjunction with superparamagnetic nano particle, the Neural stem cell effect scientific research of known deep brain area (such as hippocampus) relevant to depression can be preferably applied for.
Description
Technical field
The present invention relates to magnetic stimulating devices, fill more particularly to a kind of programmable neuromagnetic stimulation in cerebral nerve field
It sets.
Background technique
Currently, the physical therapy of electromagnetic stimulation directly acts on cerebral cortex correlation using physical agents such as electric field or magnetic fields
Function brain area remotivates neuron electrophysiologic activity under the interference of electromagnetism, it is promoted to change to normal state to reach
Therapeutic purposes.A kind of physical agent of the magnetic field as Noninvasive, effectively can cause nervous function to be modulated, living to brain area nerve
Changing has obvious action.On the other hand, electromagnetic stimulation has the adjustable advantages such as reversible, can flexibly be used to treat, and suffers to disease
Person's body and mind and ailing improvement and the raising of quality of life have positive meaning.Current main Neural stem cell therapy mainly has
Electro-shock therapy (electric shock treatment, ECT), through cranium galvanic current stimulation (transcranial direct
Current stimulation, tDCS) and transcranial magnetic stimulation (transcranial magnetic stimulation, TMS)
Treatment.
One of the representative that transcranial magnetic stimulation (TMS) is treated as electromagnetic stimulation, development have been relatively mature.TMS be by
Electric current passes through coil of the device on scalp, and fast-changing electric current can generate a pulsed magnetic field in coil, it can unimpeded nothing
Resistance ground passes through skull and brain tissue, and generates induction field in corticocerebral stimulation location.This electric field changes stimulation unit
Neuron activity in position and neuroid interconnected, fluctuates resting membrane electric potential, stimulates neuron and nerve
Network changes the excitability of cortex.The TMS pulse applied in repetitive sequence is known as repetitive transcranial magnetic stimulation (rTMS).rTMS
Most common stimulation location is back lateral prefrontal (DLPFC), and effect has obtained the affirmative of many countries, Canadian, new west
Blue, Israel approved rTMS can be used for treating depression, and U.S. FDA also ratifies TMS anti depressant therapy within 2016.Although
There are many Human Clinical Study to confirm the validity of TMS technology treatment depression, but the research of rTMS is mainly concentrated at present
In clinic, lack preclinical study, the optimum choice of overall understanding and stimulation parameter to its mechanism of action still needs to carry out a large amount of
Basic experiment early period of animal pattern is studied.
In neurology research, most common experimental animal is rodent, they can show related to human diseases
Various actions.Therefore, many scholars probe into the physical therapeutic function and mechanism of transcranial magnetic stimulation by establishing model mouse.It loses
Regret, for animal pattern (especially rodent), head is smaller, stimulates certain to be accurately positioned using existing coil
Specific brain area cortex is more difficult.It is traditional Neural stem cell mode of representative due to the attenuation effect in magnetic field using TMS, table can only be stimulated shallow
Cortex, it is impossible to be used in the Neural stem cell effect study of known deep brain area (such as hippocampus) relevant to depression.And nerve cell
Electric discharge rhythm and pace of moving things itself is in uneven distribution, and the influence that the different Neural stem cell rhythm and pace of moving things generate nervous system has why not still need to be visited together
It begs for.Different the nervous system diseases show different clinical symptoms, and the influence that the different magnetic field rhythm and pace of moving things generates is also different.And
In existing the nervous system disease animal pattern experimental study report, stimulating coil covers entire head more, and is mostly fixed magnetic
The field rhythm and pace of moving things, is unable to satisfy researcher and inquires into demand of the different Neural stem cell forms to nervous system effect.
Summary of the invention
Goal of the invention: present invention solves the technical problem that being that the prior art studied for neuromagnetic stimulation cannot achieve journey
Sequence, intelligence, existing neuromagnetic stimulation device can not be suitable for the various clinical symptom of various disease model, be not used to
Further investigate influence of the different Neural stem cell forms for the nervous system disease；Another technical problem that the present invention solves is existing
Magnetic stimulating device can not the specific brain area cortex of precise positioning, can not achieve deep brain area stimulation.
Technical solution: further including being arranged in base the present invention provides a kind of programmable neuromagnetic stimulation device, including pedestal
Rotating magnetic field generator on seat, the driving device that magnetic field generator includes magnetic head, is connected with magnetic head and magnetic head is driven to rotate are driven
Dynamic device is connected with single-chip microcontroller, single-chip microcontroller control magnetic field generator generation rotating excitation field, the magnetic field strength of the rotating excitation field with
The variation of time cycle property.Single-chip microcontroller controls the rotating excitation field that magnetic field generator generates particular rhythm, and driving device herein can be with
It is that decelerating motor and other driving mechanisms that magnetic head can be driven to rotate, monolithic processor control device use SCM Based coding
Control system controls motor speed, drives magnetic head rotation, and magnetic field generator generates the rotating excitation field of particular rhythm.Pass through modified application
Piece machine program, magnetic field generator can generate the different magnetic field rhythm and pace of moving things on demand.Programmable neuromagnetic stimulation dress provided by the invention
It sets, the difference of the magnetic field rhythm and pace of moving things according to needed for researcher, using single-chip microcontroller encoding software, such as KeilC51, code device list
Piece machine program.
Preferably, be equipped with lifting platform below the magnetic field generator, lifting platform be at a distance from magnetic head it is adjustable, pass through tune
Save distance between the two, thus it is possible to vary be applied to the magnetic field strength of experimental subjects brain.
Preferably, the adjustable distance is 0.5~5cm.Distance be 0.5cm when, can magnetic head not with experimental subjects head
The maximization that magnetic field strength is realized under the premise of contact, when distance is 5cm, magnetic field strength can be faint to being considered as 0.The present apparatus can lead to
It crosses replacement magnetic head or adjusts Height-adjustable plane at a distance from magnetic head, adjustment rotating magnetic field generator is applied to the magnetic in experimental subjects
Field intensity.
Preferably, the shape of magnetic head is cylindrical body.The magnetic field covering to the full brain of experimental subjects may be implemented in cylindrical body magnetic head.
Preferably, the magnetic head is even number, symmetrical arrangement.The magnetic head of symmetric arrays can guarantee to fill when rotated
The stability set.
Preferably, the revolving speed of motor is 0~1000r/min.Field frequency can accordingly change between 0~33Hz, both can be real
The low frequency Neural stem cell (≤1Hz) of existing neuroscience field, and can realize high frequency Neural stem cell (> 1Hz).
Preferably, lifting platform is equipped with the corresponding graticule of magnetic head running track.In use process, experimental subjects head is set
In in the graticule of lifting platform, it can be ensured that magnetic field is applied to brain.
Further, the magnetic field generator further includes the head hold for installing magnetic head.Head hold facilitates magnetic head to install,
Neural stem cell effect is good.
The magnetic stimulating device further includes SPIO nano particle, the SPIO nano particle
For core-shell structure, the shell including kernel and cladding kernel, kernel is iron oxide γ-Fe2O3Crystal, shell are polydextrose mountain
Pears alcohol carboxymethyl ester.
Further, the thickness of shell of the SPIO nano particle is 10~15nm, and the size of kernel is 6
~8nm.
Inventive principle: the Motor Rotating Speed Control System based on single-chip microcontroller encoder is used in the present invention, is compiled using computer
Code SCM program, and then motor speed and corresponding rotational time are controlled by encoder.Symmetrical cylindrical magnetic head is logical
It crosses head hold and collet is connected to the motor, driving device drives the rotating excitation field of magnetic head rotation generation particular rhythm.Fixed experiment
Object header can apply the Neural stem cell of particular rhythm on magnetic head running track to nervous system.
Using SPIO nano particle, since the particle has good biocompatibility, magnetic conductance tropism, low
Toxicity and long blood circulation time and because its small size shows its peculiar advantage.On the one hand, have to organism low thin
Cellular toxicity；On the other hand, the remanent magnetism Mr of superparamagnetic nanoparticle and coercivity H tend to be zero substantially, lead to particle and particle phase
Very faint magnetic dipole effect is only existed between mutually, can form stable magnetic fluid.By running driving device, magnetic is driven
Head rotation, magnetic field generator generate rotating excitation field and realize the magnetic stimulating device to spy in conjunction with SPIO nano particle
Determine the precise positioning of brain area cortex.
By precise positioning injection technique, SPIO nano particle is implanted into the experimental animals such as mouse or rat
Targeting brain area, or SPIO nano particle is added in Tissue Culture Dish, magnetic stimulator is utilized to apply specific section
The external magnetic field of rule is in experimental subjects.SPIO nano particle is put english outside to be turned to show magnetic under magnetic fields
Property, biological action is generated to peripheral region.
The utility model has the advantages that
(1) present invention controls driving device using single-chip microcontroller, and the rotating excitation field of particular rhythm can be generated according to Research Requirements,
By changing SCM program, the magnetic field rhythm and pace of moving things can corresponding change；
(2) magnetic stimulating device provided by the invention can adjust stimulus modality, generates the rotating excitation field of the different rhythm and pace of moving things, can be used for
Different Neural stem cell forms are furtherd investigate to the sickness influence and its potential mechanism of nervous system；
(3) the specific magnetic fields rhythm and pace of moving things that the present invention is generated by programming proves to have on biological behavioristics certain quickly anti-
Depression effect；And after the magnetic field rhythm and pace of moving things enters in conjunction with the SPIO nano particle in hippocampus with injection, it can produce
The quick antidepressant effect being remarkably reinforced；
(4) present invention is combined by the rotating excitation field of particular rhythm with superparamagnetic nano particle, can accurate Neural stem cell
Target brain area, the deeps brain area such as including hippocampus；It can be realized the stimulation of deep brain area, solve rTMS in magnetic field strength and depth
The problem of can not having both；
(5) present invention is by the specific magnetic fields rhythm and pace of moving things, in conjunction with superparamagnetic nano particle, can be preferably applied for known
The Neural stem cell effect scientific research of deep brain area (such as hippocampus) relevant to depression.
Detailed description of the invention
Fig. 1 is the three-dimensional structure diagram of magnetic stimulating device；
Fig. 2 is the main view of magnetic stimulating device；
Fig. 3 is the top view of magnetic stimulating device；
Fig. 4 is the right view of magnetic stimulating device；
Fig. 5 is the structural schematic diagram of rotating magnetic field generator；
Fig. 6 is the top view of lifting platform；
Fig. 7 is the schematic diagram of SPIO nano particle；
Fig. 8 is the waveform diagram of the rotating excitation field rhythm and pace of moving things 1 used in embodiment 2；
Fig. 9 is syrup preference experimental result；
Figure 10 is forced swim test result.
Specific embodiment
It further illustrates combined with specific embodiments below.
Embodiment 1:
It is as shown in figures 1-4 the three-dimensional structure diagram of magnetic stimulating device, magnetic stimulating device of the invention includes pedestal, pedestal
It is equipped with rotating magnetic field generator 2, positioned at the top of the device；Device is equipped with lifting platform 3, and top is equipped with control panel 4, is furnished with
The shell 5 of the SPIO nano particle that outside uses, magnetic stimulating device uses light firm engineering plastics or aluminium
Alloy, weight bearing area guarantee device stability using the biggish metal material of quality.
Rotating magnetic field generator 2 includes magnetic head 9, the driving device 1 for being connected with magnetic head 9 and driving the rotation of magnetic head 9, driving dress
It sets 1 to be connected with monolithic processor control device, monolithic processor control device controls the rotary magnetic that rotating magnetic field generator 2 generates particular rhythm
.Driving device 1 is the decelerating motor 6 of a 220-240V/72W herein, and decelerating motor 6 rotates and then magnetic head 9 is driven to rotate.
Monolithic processor control device drives magnetic head 9 to rotate using the revolving speed of SCM Based code control system control decelerating motor 6,
The rotating excitation field of the generation particular rhythm of rotating magnetic field generator 2.By changing SCM program, rotating magnetic field generator 2 can be pressed
Demand generates the different magnetic field rhythm and pace of moving things.
It is illustrated in figure 5 the structural schematic diagram of rotating magnetic field generator, rotating magnetic field generator 2 is by monolithic processor control device
The cylindrical magnetic head 9 of the head hold 8, two of decelerating motor 6, collet 7, one of control forms, monolithic processor control device and the electricity that slows down
Machine 6 is connected, and collet 7 connects and the head hold 8 of the motor shaft of the decelerating motor 6 on fixed top and lower part, and 8 two sides of head hold pass through
The magnetic head 9 of the identical cylinder of the symmetrical fixed size of screw rod 901.Cylindrical magnetic head 9 includes the identical permanent magnet of size, slows down
Motor 6 drives magnetic head 9 to rotate and then generates rotating excitation field, and the revolving speed of motor is 0~1000r/min.
It is illustrated in figure 6 the top view of lifting platform 3, lifting platform 3 is mechanical lift platform, passes through rotary elevating platform knob 301
The vertical range of i.e. adjustable experimental subjects and magnetic head, adjustable range range are 0.5cm~5cm.One is placed on lifting platform 3 can
The mounting table 10 of replacement, using engineering plastics or acrylic.Mounting table 10 marks magnetic head operation rail with visual graticule 1001
Mark, as rotating excitation field sphere of action.Mounting table 10 is equipped with fixator 1002, in use, different experiments object is placed in
It on the magnetic head running track of mounting table 10, is fixed with fixator 1002, the Neural stem cell to different experiments object can be realized,
Experimental subjects includes but is not limited to mouse, rat.
The device is equipped with control panel 4, and convenient for operation and control, control panel 4 is selected by ondoscope 401, the rhythm and pace of moving things
Device 402 and power switch 403 form.Control panel 4 is located at the top of magnetic stimulating device shell 5, and ondoscope 401 shows magnetic
The frequency for the rotating excitation field that field generator generates；Rhythm and pace of moving things selector can be 42 for selecting the different magnetic field rhythm and pace of moving things, magnetic built in the present invention
The field rhythm and pace of moving things 1 and the magnetic field rhythm and pace of moving things 2, the magnetic field rhythm and pace of moving things 2 is exactly the rotating excitation field of invariablenes turning speed 300rpm/min.By computer code,
Two kinds of magnetic field rhythm and pace of moving things built in changeable single-chip microcontroller, realize the generation of the programmable magnetic field rhythm and pace of moving things；It is controlled and is revolved by power switch 403
Turn the open and close of magnetic field generator 2.
The corresponding SCM program of the magnetic field rhythm and pace of moving things 1 is as follows:
It is illustrated in figure 7 the structural schematic diagram of SPIO nano particle, this particle becomes a fine day medicine company purchased from honest
Group, trade name is auspicious to be deposited.The SPIO nano particle is core-shell structure, including kernel 12 and coats kernel 12
Shell 11, kernel 12 are iron oxide γ-Fe2O3Crystal, shell 11 be polydextrose sorbierite carboxymethyl ester, shell 11 with a thickness of
14nm.In use, particle saves in the form of a solution, iron content 29.34mg/mL；To guarantee preparation isotonicity, interior addition is sweet
Reveal alcohol, concentration is about 44mg/mL.
It is illustrated in figure 8 the field pulses waveform diagram of the present apparatus magnetic field rhythm and pace of moving things 1.The rhythm and pace of moving things 1 is the rotating excitation field and 5Hz of 10Hz
Rotating excitation field recycled and generate with the time interval of 2s.The magnetic field rhythm and pace of moving things 2 that the present apparatus uses is 10Hz rotation for constant frequency
Magnetic field.
The magnetic stimulating device can be used for the Neural stem cell effect section of known deep brain area (such as hippocampus) relevant to depression
Research is learned, experimental subjects can be mouse, rat or other experimental cells.Neuromagnetic stimulation device may be programmed using this, use
When, experimental subjects is placed on lifting platform 3, then needs to be placed in head on 9 running track of magnetic head if animal, adjusts lifting platform 3
At a distance from magnetic head 9, power supply is opened, selects the magnetic field rhythm and pace of moving things, closes power supply after applying certain time magnetic field.
Embodiment 2:
The subjects of the present embodiment use mouse, are injected by precise positioning, by the auspicious targeting for depositing particle implantation mouse
Brain area applies external rotating excitation field in experimental subjects using magnetic stimulator.SPIO nano particle is put english outside
Turn to show magnetism under magnetic fields, biological action is generated to peripheral region.
(1) foundation and grouping of animal model
Mouse is 5-6 week old male C57BL/6 mouse (C57BL/6J JAXTMMice strain), it buys in Shang Haixi
Poole-Bi Kai experimental animal Co., Ltd.At (23 ± 1 DEG C of constant temperature of standard environment animal house；Constant humidity 55 ± 10%；12h is followed round the clock
Ring；Autonomous feed drinking-water) adapt to raising one week.It, stress (CUMS) model foundation using chronic unpredictability after adaptation
Depression model mouse.Model mouse is randomly divided into that control group, 1 group of the magnetic field rhythm and pace of moving things, magnetic field rhythm and pace of moving things 1+ are auspicious to deposit group, 2 groups of the magnetic field rhythm and pace of moving things, magnetic field
Rhythm and pace of moving things 2+ is auspicious to deposit group, and every group 8；It is blank control group that wherein control group, which is control group, neither application Neural stem cell, is also not added to examination
It tests object and carries out injection particle, as reference.
(2) Neural stem cell is carried out to mouse using magnetic stimulating device
Control group is without any processing in addition to giving CUMS modeling processing；Mouse is fixed on mouse and consolidates by 1 group of the magnetic field rhythm and pace of moving things
Determine in device, places mouse head on magnetic head running track.Height-adjustable is adjusted by adjusting the knob of lifting platform height, makes mouse
Head and magnetic head distance are 0.5cm, and the maximum magnetic field strength on mouse head surface is about 500mT at this time.It turns on the switch, motor band
Dynamic magnetic head rotation generates rotating excitation field.The magnetic field rhythm and pace of moving things 1, the visible Fig. 8 of rhythm and pace of moving things waveform diagram, field frequency are selected by rhythm and pace of moving things selector
It is found in ondoscope.Apply 5 minutes and closes device behind magnetic field.Rotating excitation field is given once daily twice, 5 minutes every time, twice
It is spaced 8h, continues 5 days.
The test method and operating procedure that 2 groups of the magnetic field rhythm and pace of moving things are substantially with 1 group of the magnetic field rhythm and pace of moving things, selection magnetic field section when applying magnetic field
Rule 2.Magnetic field rhythm and pace of moving things 1+ is auspicious deposit group need to before applying magnetic field, using brain positioning stereotactic injection technology injection 300nl it is auspicious deposit it is molten
Liquid is to hippocampus of mice, and other operations are the same as 1 group of the magnetic field rhythm and pace of moving things.Magnetic field rhythm and pace of moving things 2+ is auspicious to be deposited group operation and deposits group with magnetic field rhythm and pace of moving things 1+ is auspicious, only
It need to select the magnetic field rhythm and pace of moving things 2.
(4) judgement of antidepressant effect
The Judging index of antidepressant effect is the syrup in syrup preference experiment (sugar preference test, SPT)
Immobility in preference rate and forced swim test (forced swimming test, FST).
The experiment of syrup preference: the mouse of single cage raising is fasting for solids and liquids to be tested afterwards for 24 hours.Experiment under dark surrounds into
It goes, one bottle of 1% syrup and one bottle of clear water is placed on each mouse cage, measure 2h, 1h exchanges water bottle position.Measure syrup and clear water
The calculation method of consumption, syrup preference rate (%) is: syrup consumption/(syrup consumption+clear water consumption) × 100%.
Forced swim test: 2000ml beaker (cup body diameter 13.8cm, high 19.5cm), depth of water 15cm, water temperature 23-25
DEG C, mouse is placed in water.Other than upper required movement is bubbled through the water column on holding head, without any movement, that is, it can define
For floating or it is static be motionless.Timing 6min, the dead time of 4min, as forced swimming test result after statistics.
(4) data are analyzed
Image Acquisition is carried out to Behaviors survey using ANY-MAZE and data are analyzed.It is united using 22 software of SPSS
Count credit analysis.Data indicate that comparison among groups use one-way analysis of variance, syrup preference experimental result using mean ± standard error
With forced swim test result as shown in Fig. 9, Figure 10.
(5) analysis of experimental results
By Fig. 9, Figure 10 as it can be seen that the syrup of depression model mouse is inclined after carrying out 5 days Neural stem cells using this magnetic stimulating device
Availability ratio significantly improves, and anhedonia phenomenon is improved；Dead time significantly reduces, and behavioral despair is reversed.Compare magnetic field
1 group and 2 groups of the magnetic field rhythm and pace of moving things of the rhythm and pace of moving things, the magnetic field rhythm and pace of moving things 1 is substantially better than (the P < of the magnetic field rhythm and pace of moving things 2 to the improvement result of behavior depression
0.05)；Compare 1 group of the magnetic field rhythm and pace of moving things and rhythm and pace of moving things 1+ in magnetic field is auspicious deposits group, the rhythm and pace of moving things 2+ auspicious improvement result for depositing group in magnetic field is substantially better than magnetic
1 group of the rhythm and pace of moving things in field (P < 0.05)；Compare 2 groups of the magnetic field rhythm and pace of moving things and rhythm and pace of moving things 2+ in magnetic field is auspicious deposits group, the rhythm and pace of moving things 2+ auspicious improvement for depositing group in magnetic field is made
With being substantially better than 2 groups of the magnetic field rhythm and pace of moving things (P < 0.05).As a result the rotary magnetic for tentatively prompting neuromagnetic stimulation device of the invention to apply
Field produces activation to Central Nervous System of Mouse, and preliminary proof has quick antidepressant effect, and different sections in behaviouristics
Also there is difference in influence of the magnetic field of rule to nervous system；Meanwhile externally-applied magnetic field deposits particle brain locating injection, accurate magnetic in conjunction with auspicious
Hippocampus is stimulated, antidepressant effect is remarkably reinforced.
Claims (10)
1. a kind of programmable neuromagnetic stimulation device, including pedestal, it is characterised in that: further include the rotary magnetic of setting on the base
Field generator (2)；The driving that rotating magnetic field generator (2) includes magnetic head (9), is connected with magnetic head (9) and magnetic head (9) is driven to rotate
Device (1), driving device (1) are connected with single-chip microcontroller, and single-chip microcontroller controls rotating magnetic field generator (2) and generates rotating excitation field, described
The cyclically-varying at any time of the magnetic field strength of rotating excitation field.
2. programmable neuromagnetic stimulation device according to claim 1, it is characterised in that: the rotating magnetic field generator
(2) lower section is equipped with lifting platform (3), and lifting platform (3) is adjustable at a distance from magnetic head (9).
3. programmable neuromagnetic stimulation device according to claim 2, it is characterised in that: the lifting platform (3) and magnetic head
(9) adjustable distance is 0.5cm~5cm.
4. programmable neuromagnetic stimulation device according to claim 1, it is characterised in that: the shape of magnetic head (9) is cylinder
Body.
5. programmable neuromagnetic stimulation device according to claim 1, it is characterised in that: the magnetic head (9) is even number,
Symmetrical arrangement.
6. programmable neuromagnetic stimulation device according to claim 1, it is characterised in that: the revolving speed of magnetic head (9) rotation is 0
~1000r/min.
7. programmable neuromagnetic stimulation device according to claim 1, it is characterised in that: lifting platform (3) is equipped with magnetic head
(9) the corresponding graticule of running track (1001).
8. programmable neuromagnetic stimulation device according to claim 1, it is characterised in that: the rotating magnetic field generator
It (2) further include for installing the head hold of magnetic head (9) (8).
9. programmable neuromagnetic stimulation device according to claim 1, it is characterised in that: the magnetic stimulating device further includes
SPIO nano particle, the SPIO nano particle are core-shell structure, including kernel (12) and packet
The shell (11) of kernel (12) is covered, kernel (12) is iron oxide γ-Fe2O3Crystal, shell (11) are polydextrose sorbierite carboxylic first
Base ether.
10. programmable neuromagnetic stimulation device according to claim 1, it is characterised in that: the Superparamagnetic Iron Oxide
The shell (11) of nano particle is with a thickness of 10~15nm.
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| CN113041501A (en) * | 2021-03-22 | 2021-06-29 | 东南大学 | Method for quickly resisting depression by combining magnetic stimulation system and targeting visual cortex |
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| WO2004091390A2 (en) * | 2003-04-15 | 2004-10-28 | Philips Intellectual Property & Standards Gmbh | Device and method for examination and use of an electrical field in an object under examination containing magnetic particles |
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