CN109580595B - Chemiluminescent detector, incubation device and reaction disk mechanism - Google Patents
Chemiluminescent detector, incubation device and reaction disk mechanism Download PDFInfo
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- CN109580595B CN109580595B CN201710903187.XA CN201710903187A CN109580595B CN 109580595 B CN109580595 B CN 109580595B CN 201710903187 A CN201710903187 A CN 201710903187A CN 109580595 B CN109580595 B CN 109580595B
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 625
- 230000007246 mechanism Effects 0.000 title claims abstract description 130
- 238000011534 incubation Methods 0.000 title claims abstract description 117
- 238000010438 heat treatment Methods 0.000 claims abstract description 115
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 47
- 238000001514 detection method Methods 0.000 claims abstract description 33
- 238000002156 mixing Methods 0.000 claims abstract description 21
- 238000009413 insulation Methods 0.000 claims description 101
- 229920000742 Cotton Polymers 0.000 claims description 70
- 238000012544 monitoring process Methods 0.000 claims description 45
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- 238000004321 preservation Methods 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000005485 electric heating Methods 0.000 description 5
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- 230000009471 action Effects 0.000 description 4
- 230000003139 buffering effect Effects 0.000 description 4
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- 238000003018 immunoassay Methods 0.000 description 3
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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Abstract
The invention provides a reaction disk mechanism, comprising: a rotatable reaction carrying disk capable of accommodating the reaction cup; and the heating structure comprises a constant temperature seat and a heating piece, wherein the constant temperature seat is arranged below the reaction bearing disc, the heating piece is arranged below the constant temperature seat, the heating piece heats the constant temperature seat, and the reaction cup in the reaction bearing disc is heated through the constant temperature seat. The sample in the reaction cup of the reaction bearing disc can be heated uniformly, the incubation effect of the sample is ensured, and the sample detection result is further ensured to be accurate. The invention also provides a chemiluminescent detector and an incubation device, and the reaction disk mechanism can enable the reaction cup, sample, reagent, mixing, incubation and the like of the incubation device to be carried out in a blocking way after being applied to the incubation device, so that the detection speed of the chemiluminescent detector is improved, and the detection efficiency is further ensured.
Description
Technical Field
The invention relates to the technical field of chemiluminescent detection, in particular to a chemiluminescent detector, an incubation device and a reaction disc mechanism.
Background
The chemiluminescent immunoassay is a non-radiolabeled immunoassay established on the basis of the theory of the radioimmunoassay technology and using a labeled luminescent agent as a tracer signal, and is widely carried out in the research and application of the contemporary biological detection technology. The kit has the advantages of high specificity, high sensitivity, simple separation, no toxicity, safety and stability, no environmental pollution and the like, and particularly can obtain experimental results in a short time, thus being deeply favored by test medical workers and clinicians.
In general, chemiluminescent detectors based on biochemical immunoassay have become established medical diagnostic devices. However, the universal chemiluminescent detector has the disadvantages of high price, heavy volume, large power consumption and difficult popularization and promotion. With the high-speed development of biomedical equipment, the full automation of the chemiluminescent detector is realized under certain conditions.
The chemiluminescent detector mainly comprises a reaction cup loading device, a sample adding device, an incubation reaction device, a cleaning device, a luminescent detection device, a control system and a software system. Typically, the incubation reaction apparatus is in an intermediate position and serves as a single station for incubating the reactants in the reaction vessel, and the incubation reaction apparatus is used to perform the incubation operations, and the various steps prior to incubation, such as adding the reaction cup, adding the sample, adding the reagents, and mixing, etc., need to be performed on other structures. However, the temperature uniformity in the conventional incubation reaction device is not high, the temperature deviation is large, the incubation reaction of the sample is not thorough, and the accuracy of sample detection is reduced.
Disclosure of Invention
In view of the above, it is necessary to provide a reaction tray mechanism capable of ensuring a sample incubation effect by making the temperature distribution uniform, and an incubation apparatus comprising the reaction tray mechanism, and a chemiluminescent detector comprising the incubation apparatus, in order to solve the problems of poor sample incubation caused by low temperature uniformity and large temperature deviation in the conventional incubation reaction apparatus.
The above purpose is achieved by the following technical scheme:
A reaction disk mechanism comprising:
A rotatable reaction carrying disk capable of accommodating the reaction cup; and
The heating structure comprises a constant temperature seat and a heating piece, wherein the constant temperature seat is arranged below the reaction bearing disc, the heating piece is arranged below the constant temperature seat, the heating piece heats the constant temperature seat, and the reaction cup in the reaction bearing disc is heated through the constant temperature seat.
In one embodiment, the constant temperature seat is provided with a constant temperature groove, wen Yokong for placing the reaction cup is arranged on the reaction bearing plate, and the Wen Yokong is arranged corresponding to the constant temperature groove.
In one embodiment, a preset gap exists between the constant temperature seat and the reaction carrying disc, and when the reaction carrying disc rotates relative to the constant temperature seat, air flow can flow in the preset gap.
In one embodiment, the constant temperature seat comprises a constant temperature bottom plate and a plurality of constant temperature baffles arranged on the constant temperature bottom plate;
the constant temperature baffles are sleeved layer by layer, and a constant temperature groove is formed between two adjacent constant temperature baffles.
In one embodiment, the reaction carrying disc is disc-shaped, the constant temperature bottom plate is disc-shaped, the constant temperature baffles are annular, and an annular constant temperature groove is formed between two adjacent constant temperature baffles.
In one embodiment, the number of Wen Yokong is plural, a plurality of Wen Yokong are arranged in a row along the radial direction of the reaction carrier disk, and a plurality of Wen Yokong are distributed in a ring shape at equal radius.
In one embodiment, any two adjacent Wen Yokong in the radial direction of the reaction-carrying disk are respectively positioned in two adjacent thermostats;
and Wen Yokong adjacent to each other in the circumferential direction of the reaction carrying disc are positioned in the same corresponding constant temperature groove.
In one embodiment, each of the constant temperature baffles is provided with a plurality of circulation grooves, and the circulation grooves are communicated with any two adjacent constant temperature grooves.
In one embodiment, the heating structure further comprises a heating band clamping block, wherein the heating band clamping block is arranged below the heating piece, and the heating band clamping block can fix the heating piece on the constant temperature seat.
In one embodiment, the reaction plate mechanism further comprises a temperature monitoring structure disposed on the thermostatic seat, the temperature monitoring structure being capable of monitoring the temperature of the thermostatic seat.
In one embodiment, the temperature monitoring structure comprises a plurality of temperature monitoring components, and the temperature monitoring components are arranged along different annular directions and different radial directions of the constant temperature seat.
In one embodiment, the reaction disk mechanism further includes a temperature control structure, the temperature control structure is electrically connected with the temperature monitoring structure and the heating element, the temperature monitoring structure can feed back the monitored signals of the temperature of the constant temperature seat and the ambient air temperature to the temperature control structure, and the temperature control structure can control the heating value of the heating element according to the received signals.
In one embodiment, the heating element is an electric heating element, and the temperature control structure can control the current flowing into the electric heating element according to the received signal.
In one embodiment, the reaction disk mechanism further comprises a reaction disk mounting structure and a reaction disk driving structure in transmission connection with the reaction bearing disk;
the reaction disk driving structure drives the reaction bearing disk to rotate relative to the reaction disk mounting structure.
In one embodiment, the reaction disk driving structure comprises a rotary platform and a rotary cushion block, a rotary hole is formed in the middle area of the reaction bearing disk, the rotary cushion block is installed in the rotary hole and connected with the reaction bearing disk, the rotary platform is connected with the rotary cushion block, and the rotary platform drives the rotary cushion block to drive the reaction bearing disk to rotate.
In one embodiment, the reaction tray mechanism further comprises a heat insulation structure, the heat insulation structure is arranged around the circumference of the reaction carrying tray, the heating structure is arranged between the heat insulation structure and the reaction carrying tray, and the heat insulation structure is used for heat insulation of the reaction carrying tray.
In one embodiment, the insulation structure comprises bottom insulation cotton and outer wall insulation cotton, the bottom insulation cotton is arranged below the heating structure, the outer wall insulation cotton is arranged on the bottom insulation cotton, and the outer wall insulation cotton is arranged on the periphery of the reaction bearing disc in a surrounding mode.
In one embodiment, the insulation structure further comprises an inner wall insulation cotton, wherein the inner wall insulation cotton is arranged on the bottom insulation cotton and is positioned on the outer side of the rotary cushion block.
In one embodiment, the reaction tray mechanism further comprises a thermal insulation cover structure for covering the reaction carrying tray, the thermal insulation cover structure comprises a cover body and a cover body support for supporting the cover body, the cover body support is arranged on the reaction tray mounting structure, and the cover body support supports the cover body on the reaction tray mounting structure.
In one embodiment, the heat insulation cover structure further comprises an observation cover, wherein an observation window is formed in the cover body, and the observation cover is switchably located in the observation window of the cover body.
In one embodiment, the cover body is provided with a Wen Yofang cup groove and a cleaning cup taking groove, the reaction disk mounting structure is provided with an incubation cup placing station area and a cleaning cup taking station area, the Wen Yofang cup groove corresponds to the Wen Yofang cup station area, the cleaning cup taking groove corresponds to the cleaning cup taking station area, and the cup grabbing mechanism can place a reaction cup in the Wen Yokong at the Wen Yofang cup groove and can take out the reaction cup in the Wen Yokong through the cleaning cup taking groove.
In one embodiment, the Wen Yofang cup grooves and the cleaning cup-taking grooves extend along the radial direction of the reaction-bearing plate, and correspond to any one row of Wen Yokong arranged along the radial direction.
In one embodiment, the thermal insulation cover structure further comprises a locking assembly, wherein the locking assembly is arranged on the cover body and the cover body support column, and the locking assembly can lock the cover body on the cover body support column.
In one embodiment, the locking assembly comprises a locking member and a locking member, the locking member is movably arranged on the cover body, the locking member is fixed on the top of the cover body support column, the locking member is matched with the locking member, and the locking member locks the cover body on the cover body support column.
In one embodiment, the locking assembly further comprises a stirring piece, the stirring piece is movably arranged on the cover body, the stirring piece is connected with the locking piece, and the stirring piece can drive the locking piece to move so that the locking piece is locked or separated from the locking piece.
In one embodiment, the heat insulation cover structure further comprises a cover measuring member and a cover body sensing member, wherein the cover measuring member is arranged on the cover body support column, the cover body sensing member is arranged on the cover body, and the cover body sensing member can detect the position of the cover measuring member.
In one embodiment, the thermal insulation cover structure further comprises a fixing component, the fixing component connects the thermal insulation structure with the cover body, and the fixing component can fix the cover body on the thermal insulation structure.
In one embodiment, the fixing component comprises an annular outer pressing block and a guide pin, the annular outer pressing block is arranged between the cover body and the outer wall heat insulation cotton, and the guide pin penetrates through the cover body and is arranged in the annular outer pressing block; the annular inner pressing block is arranged between the inner wall heat insulation cotton and the cover body.
Also relates to an incubation device, comprising a buffer disc mechanism, a reaction outer disc mechanism and a reaction disc mechanism according to any technical characteristic;
The buffer disc mechanism comprises a rotatable buffer bearing disc, wherein the buffer bearing disc can accommodate a reaction cup and can enable the reaction cup to finish sample adding operation on the buffer bearing disc;
The reaction outer disc mechanism comprises a rotatable reaction outer disc bearing disc, and the reaction outer disc bearing disc can accommodate the reaction cup transferred from the buffer disc mechanism and can enable the reaction cup to finish the reagent adding operation and the mixing operation on the reaction outer disc mechanism;
the reaction tray of the reaction tray mechanism is capable of accommodating the reaction cups transferred from the reaction outer tray and of performing an incubation operation on the reaction tray mechanism;
the buffer bearing disc, the reaction outer disc bearing disc and the reaction bearing disc can rotate independently.
In one embodiment, the reaction outer disc bearing disc is circular, and the reaction bearing disc is disc-shaped;
the reaction outer disc bearing disc is sleeved on the outer side of the reaction bearing disc, and the buffer bearing disc is independent of the reaction outer disc bearing disc.
The chemiluminescent detector is characterized by comprising a reaction cup automatic transmission device, a sample adding device, a cleaning device, a luminescent detection device, a control device and an incubation device according to any technical characteristics;
The control device transfers the reaction cups in the automatic reaction cup conveying device to the incubation device, controls the sample adding device to add samples to the reaction cups in the incubation device, and controls the reaction cups to be sequentially transferred to the cleaning device and the light-emitting detection device after incubation is completed.
After the technical scheme is adopted, the beneficial effects of the invention are as follows:
According to the chemiluminescent detector, the incubation device and the reaction disk mechanism, the reaction bearing disk heats the reaction cup in the reaction bearing disk through the heating structure, specifically, the heating element firstly heats the constant temperature seat, then the constant temperature seat heats the reaction bearing disk and the reaction cup in the reaction bearing disk, after the heating element heats the constant temperature seat, the constant temperature seat can uniformly distribute the temperature on the constant temperature seat, so that the problem that sample incubation is poor due to low temperature uniformity and large temperature deviation in the conventional incubation reaction device is effectively solved, samples in the reaction cup of the reaction bearing disk are uniformly heated, the incubation effect of the samples is ensured, and further, the sample detection result is ensured to be accurate. Meanwhile, as the distance between the constant temperature seat and the reaction cup is small, the heating speed can be improved, so that the sample incubation reaction is thorough, and the accuracy of sample detection is improved. Moreover, after the reaction disc mechanism is applied to the incubation device, the reaction cup, the sample, the reagent, the mixing, the incubation and the like of the incubation device can be carried out in a blocking mode, the problems of long operation time caused by time occupation and large space occupation of each section of working procedure of the current sample reaction are solved, the detection speed of the chemiluminescent detector is improved, and the detection efficiency is further guaranteed.
Drawings
FIG. 1 is a schematic view showing the structure of an incubator according to an embodiment of the present invention;
FIG. 2 is a schematic structural view of the reaction outer tray mechanism and the reaction tray mechanism in the incubation apparatus shown in FIG. 1;
FIG. 3 is a schematic view of the reaction outer tray mechanism and the reaction tray mechanism shown in FIG. 2 with the heat-retaining cover removed;
FIG. 4 is a perspective view of the reaction disk mechanism shown in FIG. 2;
FIG. 5 is a schematic cross-sectional structural view of the reaction disk mechanism shown in FIG. 4;
FIG. 6 is a top view of the reaction disk mechanism of FIG. 4 with the insulating cover structure removed;
FIG. 7 is a perspective view of a thermostatic seat in the reaction disk mechanism shown in FIG. 5;
FIG. 8 is a perspective view of a thermal cover structure of the second reaction disk mechanism shown in FIG. 6;
FIG. 9 is a block diagram of the locking assembly of the insulating cover structure of FIG. 8 when locked;
FIG. 10 is a block diagram of the locking assembly of the insulating cover structure of FIG. 8 when unlocked;
Wherein:
1-an incubation device;
11-a buffer tray mechanism;
12-a reaction outer disc mechanism;
121-reaction outer disk carrier disk;
13-a reaction disk mechanism;
131-reaction carrier plate;
1311-Wen Yokong;
132-reaction disk mounting structure;
1321-reaction mounting floor;
1322-reaction support column;
1323-reaction mounting column;
133-reaction disk drive structure;
1331-rotating platform;
1332-rotating pad;
134-reaction detection structure;
1341-reaction detection piece;
1342-reaction sensing element;
135-heating structure;
1351-a constant temperature seat; 13511-constant temperature bottom plate; 13512-constant temperature baffle; 13513-flow-through tanks; 1352-heating element;
1353-heating the belt clamp block;
136-a thermal insulation structure;
1361-bottom insulation cotton;
1362-inner wall insulation cotton;
1363-outer wall insulation cotton;
1364-insulating blocks;
137-a heat preservation cover structure;
1371-cover; 13711-Wen Yofang cup slots; 13712-cleaning a cup taking groove;
1372-cover posts;
1373-locking assembly; 13731-locking member; 13732-locking member; 13733-toggle;
13731-locking member; 137311-rotating member; 137312-locking the shaft;
13732-locking member; 137321-locking the platform; 137322-bump;
13733-toggle; 137331 unlocking bars; 137332-locking bars;
1374-core cap;
1377-securing assembly; 13771-annular outer briquette; 13772 guide pins; 13773-annular inner pressing blocks;
1378-core insulation cotton;
1379-viewing cap;
2-reaction cup.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the chemiluminescent detector, the incubation device and the reaction plate mechanism of the present invention will be described in further detail below by way of examples with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The numbering of the components itself, e.g. "first", "second", etc., is used herein merely to distinguish between the described objects and does not have any sequential or technical meaning. The term "coupled" as used herein includes both direct and indirect coupling (coupling), unless otherwise indicated. In the description of the present application, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the device or element in question must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present application.
In the present invention, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.
Referring to fig. 1 to 3, the present invention provides a reaction disk mechanism 13, and the reaction disk mechanism 13 can perform an incubation operation on a reaction cup 2 after a sample and a reagent are uniformly mixed, so that the sample and the reagent can sufficiently react, and the accuracy of sample detection is ensured. The reaction disk mechanism 13 is applied to a chemiluminescent detector of the incubation device 1, and the incubation device 1 is used for carrying out incubation operation on samples and operations such as sample adding, reagent adding and the like before incubation, so that the chemiluminescent detector can carry out analysis and detection on the samples after incubation to obtain corresponding detection results, and the use requirements are met. It should be noted that the specific kind of the sample to be measured is not limited, and in some embodiments, the sample to be measured includes a solid sample or a liquid sample. Further liquid samples include, but are not limited to, blood samples. The reaction disk mechanism 13 can ensure that the sample, the reagent and other contents in the reaction cup 2 are heated uniformly, solves the problem of poor sample incubation caused by low temperature uniformity and large temperature deviation in the conventional incubation reaction device, ensures that the sample and the reagent in the reaction cup 2 of the reaction bearing disk 131 are heated uniformly, ensures the incubation effect of the sample, further ensures the accuracy of the sample detection result, and ensures the usability of the chemiluminescent detector.
Referring to fig. 4 to 7, in the present invention, the reaction plate mechanism 13 includes a rotatable reaction carrier plate 131. The reaction carrying disk 131 can accommodate the reaction cup 2, specifically, the reaction carrying disk 131 can accommodate the reaction cup 2 after the sample and the reagent are uniformly mixed, and can make the reaction cup 2 perform incubation operation on the reaction disk mechanism 13. The cuvette 2 after mixing the sample with the reagent is transferred to the cuvette mechanism 13, and then the cuvette 2 is incubated by the cuvette mechanism 13, and after a predetermined time, the cuvette 2 is transferred away for the next process operation. Moreover, the rotatable setting of reaction bearing plate 131 can make the position that needs to place reaction cup 2 on the reaction bearing plate 131 be close to getting cup department and putting cup department, reduces the transfer route of reaction cup 2 like this, improves transfer efficiency, and then guarantees chemiluminescent detector's operating efficiency.
The reaction disk mechanism 13 further includes a reaction disk mounting structure 132 and a reaction disk drive structure 133 drivingly connected to the reaction carrier disk 131. The reaction disk drive structure 133 drives the reaction carrier disk 131 to rotate relative to the reaction disk mounting structure 132. The reaction disk mounting structure 132 is used for bearing and mounting, the reaction disk driving structure 133 is mounted on the reaction disk mounting structure 132, and other parts of the reaction disk mechanism 13 are also mounted on the reaction disk mounting structure 132, the reaction bearing disk 131 is mounted on the reaction disk driving structure 133, and the reaction disk driving structure 133 drives the reaction bearing disk 131 to rotate, so that the reaction bearing disk 131 rotates to a corresponding position, and corresponding operations such as cup adding, cup taking and the like are performed.
Specifically, reaction disk mounting structure 132 includes reaction mounting plate 1321 and reaction support posts 1322. Reaction support post 1322 can support reaction mounting plate 1321 on the top of a chemiluminescent detector. Reaction disk drive structure 133 is mounted to reaction mounting plate 1321. The reaction disc driving structure 133 comprises a rotary platform 1331 and a rotary cushion block 1332, the rotary cushion block 1332 is mounted on the rotary platform 1331, the rotary platform 1331 is further connected with the reaction bearing disc 131, the rotary platform 1331 can drive the rotary cushion block 1332 to drive the reaction bearing disc 131 to rotate, the reaction bearing disc 131 drives the corresponding Wen Yokong 1311 to rotate to the corresponding station, and corresponding operation is performed.
Preferably, the rotary stage 1331 is an independently rotatable device that integrates motors, guide bearings, gear drives, electronic control elements, and the like, has an independent integral power plant, and can be directly driven. In this embodiment, the rotary platform 1331 has a rotor protruding from the rotary platform 1331. The rotating cushion 1332 is mounted on the rotor, and the rotating cushion 1332 can fix the reaction bearing disc 131 on the rotor, and the rotor can drive the rotating cushion 1332 to rotate, so as to drive the reaction bearing disc 131 and Wen Yokong 1311 thereon to rotate. The rotating platform 1331 has the advantages of simple installation and maintenance, compact structure, small volume and self-contained deceleration kinetic energy, and can directly drive the reaction bearing disc 131 to rotate. The debugged rotary platform 1331 can be taken as a part to be disassembled and assembled, so that great portability, easy disassembly and maintenance are brought to the assembly, debugging and maintenance of the transmission assembly. Of course, in other embodiments of the present invention, the rotating platform 1331 may be replaced by a combination of a reaction driving motor and a transmission structure such as a gear transmission assembly and a synchronous belt transmission assembly, where an output end of the transmission structure is connected to the reaction bearing disc 131 to drive the reaction bearing disc 131 to rotate.
Preferably, the reaction carrier plate 131 has a hollow structure, i.e., a rotation hole is formed in a middle region of the reaction carrier plate 131, and the rotation pad 1332 is installed in the rotation hole. The method comprises the following steps: the rotary cushion block 1332 stretches into the rotary hole and is abutted with the inner wall of the rotary hole, so that the rotary cushion block 1332 is connected with the reaction bearing disc 131, and the rotor of the rotary platform 1331 can drive the rotary cushion block 1332 to rotate, so that the reaction bearing disc 131 is driven to rotate. Optionally, the rotary cushion 1332 is also hollow, so that the moment of inertia of the rotary cushion 1332 during rotation can be reduced, and meanwhile, other parts of the reaction disc mechanism 13 can be installed in the rotary cushion 1332, so that the volume of the reaction disc mechanism 13 is reduced.
Further, a plurality of Wen Yokong 1311 for placing the reaction cup 2 are provided on the reaction carrier plate 131. The cuvette 2 after the sample and the reagent are uniformly mixed is transferred to Wen Yokong 1311 of the reaction carrier plate 131, and then the cuvette 2 in Wen Yokong 1311 is incubated by the reaction plate mechanism 13, and after a preset time, the cuvette 2 in the reaction carrier plate 131 is taken out and transferred to a preset position, i.e. a cleaning device, for the next operation. Further, a plurality of incubation holes 1311 are arranged in a row in the radial direction of the reaction-carrying disk 131, and the plurality of incubation holes 1311 are radially distributed on the reaction-carrying disk 131. This enables the incubation holes 1311 to be arranged in order on the reaction carrier plate 131, enabling the addition or removal of the cuvette 2 into or from the incubation holes 1311 at a fixed position. The plurality of incubation wells 1311 are distributed annularly at equal radii. After the incubation holes 1311 are arranged in a row, a plurality of Wen Yokong 1311 with equal radius are circularly distributed along a connecting line in the circumferential direction, and a plurality of Wen Yokong 1311 which are circularly distributed are concentrically arranged around the center of the reaction bearing disc 131, so that the incubation holes 1311 are radially distributed relative to the center of the reaction bearing disc 131. Still further, the number of any two adjacent columns Wen Yokong 1311 is different. So can make and arrange more Wen Yokong 1311 on the reaction bearing plate 131, and then increase the interpolation quantity of reaction cup 2, can realize simultaneously that a plurality of reaction cups 2 carry out the incubation operation, improve the incubation rate of reaction cup 2, then improve the detection rate of chemiluminescence detector.
In order to ensure that the sample and the reagent react sufficiently, the incubation operation of the sample and the reagent needs to be performed in an environment of about 37 ℃. Typically, the reaction plate mechanism 13 further includes a heating structure 135, where the heating structure 135 is disposed below the reaction plate 131, and the heating structure 135 is used to heat the reaction plate 131. The heating structure 135 can generate heat to heat the reaction carrying disc 131, so that the temperature in Wen Yokong 1311 of the reaction carrying disc 131 is about 37 ℃, and thus, when the reaction cup 2 is transferred into Wen Yokong 1311 of the reaction carrying disc 131, the heating structure 135 can heat the reaction cup 2 in Wen Yokong 1311, thereby providing an incubation environment for the reaction of the sample and the reagent in the reaction cup 2, ensuring that the reaction of the sample and the reagent can be normally performed, enabling the sample and the reagent to be fully reacted, and further facilitating the subsequent luminescence detection of the sample.
Preferably, the heating structure 135 and the reaction carrier plate 131 are independently disposed, so that inertia of the reaction carrier plate 131 during rotation can be reduced, and stable and reliable rotation of the reaction carrier plate 131 is ensured. Moreover, when the reaction disk driving structure 133 drives the reaction carrier disk 131 to rotate, the reaction carrier disk 131 can rotate relative to the heating structure 135, and at this time, the heating structure 135 can heat each part of the reaction carrier disk 131 and the reaction cup 2 therein, so that the temperature of each part of the reaction carrier disk 131 is uniform, and then the reaction effect of the sample and the reagent is ensured. Optionally, reaction disk mounting structure 132 further includes reaction mounting posts 1323, and heating structure 135 is mounted to reaction disk mounting structure 132 by reaction mounting posts 1323. Of course, in other embodiments of the invention, the heating structure 135 may be secured to the reaction carrier plate 131 or to the reaction mounting plate 1321 of the reaction plate mounting structure 132 by other structures.
Specifically, the heating structure 135 includes a constant temperature seat 1351 and a heating element 1352, the constant temperature seat 1351 is disposed below the reaction carrier plate 131, the heating element 1352 is disposed below the constant temperature seat 1351, and the heating element 1352 heats the constant temperature seat 1351 and heats the reaction cup 2 in the reaction carrier plate 131 through the constant temperature seat 1351. The heat generated after the heating element 1352 is electrified and heated can be transferred to the constant temperature seat 1351 with good heat conduction performance, so that large-area heat radiation is formed around the constant temperature seat 1351, and the second reaction bearing disc 131 is rapidly heated and supplemented, so that the heating effect of the second reaction bearing disc 131 is ensured, and the heating efficiency is improved. It can be understood that the constant temperature seat 1351 can uniformly distribute the heat generated by the heating element 1352, so as to uniformly heat the reaction carrying tray 131 and the reaction cups 2 therein, so that the temperature of the environment where the reaction cups 2 at each position of the reaction carrying tray 131 are located is consistent, the environment where the sample reacts with the reagent is consistent, and the incubation effect of the sample is ensured. In the present embodiment, the constant temperature seat 1351 is a metal constant temperature seat, and the heating element 1352 is a silica gel heating belt. Of course, in other embodiments of the present invention, the thermostatic seat 1351 may be other types of thermostatic structures, and the heating element 1352 may be a heating film or other types of heating structures 135.
Further, the thermostatic seat 1351 is provided with a thermostatic bath, and Wen Yokong 1311 of the reaction carrying tray 131 is arranged corresponding to the thermostatic bath. When the reaction cup 2 is transferred to the Wen Yokong 1311 of the reaction carrying tray 131, the reaction cup 2 can be disposed corresponding to the thermostat, and at this time, the heat generated by the heating element 1532 can exist in the thermostat through the thermostat base 1531, and then the reaction cup 2 corresponding to the thermostat can be heated, so that the sample in the reaction cup 2 fully reacts with the reagent. Preferably, after the incubation well 1311 is projected onto the thermostatic seat 1351, wen Yokong 1311 is located in the thermostatic bath. It will be appreciated that the reaction cup 2 is transferred to the Wen Yokong and 1311 of the reaction tray 131, and the reaction cup 2 can extend into the thermostatic bath through the Wen Yokong and 1311, at this time, the reaction cup 2 is just positioned in the thermostatic bath, so that the heat in the thermostatic bath can directly heat the reaction cup 2, and the heating effect of the reaction cup 2 is further ensured. Moreover, a preset gap exists between the constant temperature seat 1351 and the reaction carrier plate 131, and when the reaction carrier plate 131 rotates relative to the constant temperature seat 1351, air flow can flow in the preset gap. It can be understood that the reaction carrier plate 131 can accelerate the airflow during rotation, so that the airflow can circulate in the preset gap to ensure the uniform temperature of the constant temperature seat 1351, and further ensure the uniform temperature on the reaction carrier plate 131. Meanwhile, the existence of the preset gap can prevent the movement of the reaction carrying disc 131 from interfering with the constant temperature seat 1351, so as to ensure that the constant temperature seat 1351 rotates stably.
As one embodiment, the thermostatic base 1351 comprises a thermostatic base plate 13511 and a plurality of thermostatic baffles 13512 disposed on the thermostatic base plate 13511. The plurality of constant temperature baffles 13512 are sleeved layer by layer, and a constant temperature groove is formed between two adjacent constant temperature baffles 13512. It will be appreciated that the thermostatic bath is surrounded by two adjacent concentrically arranged thermostatic baffles 15312. The heating piece 1352 is located at the bottom of the thermostatic base plate 13511, heat generated during heating of the heating piece 1352 can be completely transferred to the thermostatic base plate 13511, the thermostatic baffle plate 13512 is arranged on the thermostatic base plate 13511, the thermostatic baffle plate 13512 can increase the heat dissipation area of the thermostatic base plate 13511, and heat on the thermostatic base plate 13511 can be ensured to act on the reaction bearing disc 131. Moreover, a preset distance exists between two adjacent constant temperature baffles 13512 to enclose into a constant temperature tank, after a plurality of constant temperature baffles 13512 are sleeved layer by layer, a plurality of constant temperature tanks can be formed, and heat emitted by the constant temperature baffles 13512 can be left in the constant temperature tanks. After the reaction bearing disc 131 bears the reaction cup 2, the reaction cup 2 can be located in the constant temperature tank, and the reaction cup 2 is heated by heat in the constant temperature tank, so that the sample and the reagent fully react. Meanwhile, the distance between the constant temperature seat 1351 and the reaction cup 2 is small, the heating speed can be improved, the sample incubation reaction is thorough, and the accuracy of sample detection is improved.
Preferably, the reaction carrier plate 131 has a disk shape, the thermostatic base plate 13511 has a disk shape, the plurality of thermostatic baffles 13512 has a circular ring shape, and the diameters of the plurality of thermostatic baffles 13512 are different. The plurality of constant temperature baffles 13512 are sleeved layer by taking the circle center of the constant temperature bottom plate 13511 as a reference, and a space exists between any two adjacent constant temperature baffles 13512 to form a circular constant temperature groove. Thus, the reaction bearing disc 131 can be conveniently matched with the annular constant temperature groove in a rotating way, interference is avoided, and stable and reliable operation of the reaction disc mechanism 13 is ensured.
Moreover, any adjacent two incubation holes 1311 in the radial direction of the reaction-carrying disk 131 are located in the adjacent two thermostats, respectively. Wen Yokong 1311 adjacent in the circumferential direction of the reaction-carrying disk 131 are each located in the corresponding identical thermostatic bath. It will be appreciated that each turn of incubation hole 1311 of the reaction-carrying tray 131 corresponds to a thermostatic bath between two adjacent thermostatic baffles 13512 of the thermostatic seat 1351. In this way, each thermostatic bath is able to heat the reaction cup 2 in a corresponding turn of incubation hole 1311 on the reaction-carrying disk 131. After the cuvette 2 is transferred to Wen Yokong and 1311 of the reaction carrier plate 131, the cuvette 2 passes through Wen Yokong and 1311 to be inserted into the thermostatic bath, and the heat of the thermostatic seat 1351 can directly heat the cuvette 2 and the sample and reagent therein. Moreover, when the reaction disk driving structure 133 drives the reaction carrying disk 131 to rotate, the reaction carrying disk 131 can drive the reaction cup 2 to move in the constant temperature tank. Like this, reaction cup 2 can disturb the air current in the constant temperature tank for the air current in the constant temperature tank mixes, and then makes each position temperature even, guarantees that reaction bearing plate 131 and reaction cup 2 on it are heated evenly, guarantees the heating effect of sample. Preferably, the distance between two adjacent constant temperature baffles 13512 is larger than the dimension of the reaction cup 2 along the radial direction of the reaction carrying disk 131, so that the reaction cup 2 will not interfere with the constant temperature baffles 13512 when the reaction carrying disk 131 is driven by the reaction disk driving structure 133 to rotate the reaction cup 2.
Optionally, each thermostatic baffle 13512 is provided with a plurality of flow grooves 13513, and the flow grooves 13513 are communicated with any two adjacent thermostatic tanks. When the rotating platform 1331 drives the reaction bearing disc 131 to rotate, the reaction bearing disc 131 can disturb the annular constant temperature grooves and the air flow between the two adjacent annular constant temperature grooves, so that heat in each constant temperature groove is accelerated to flow between the rings, heat in the constant temperature seat 1351 is more uniform, an air bath is formed around the constant temperature seat 1351, a good incubation environment is provided for a sample, the sample incubation effect is guaranteed, and then the reliability of sample detection is guaranteed. Of course, in other embodiments of the present invention, the flow channel 13513 may be replaced with a flow hole or other structure that enables air flow between any two adjacent thermostats.
Optionally, the heating structure 135 further includes a heating belt clamping block 1353, the heating belt clamping block 1353 is disposed below the heating member 1352, and the heating belt clamping block 1353 is capable of fixing the heating member 1352 to the constant temperature seat 1351. The heating belt clamp block 1353 can play a fixed role to be fixed in the bottom of constant temperature seat 1351 with heating piece 1352, avoid the position drunkenness of heating piece 1352 to influence the heating effect, guarantee the fixed position of heating piece 1352, guarantee the heating effect then. Moreover, the heating belt clamp 1353 also enables the heating member 1352 to be uniformly attached to the constant temperature seat 1351, so as to efficiently and uniformly heat the constant temperature seat 1351. Preferably, the heating belt clamping block 1353, the heating member 1352 and the constant temperature seat 1351 are hollow structures, and the heating belt clamping block 1353, the heating member 1352 and the constant temperature seat 1351 are all sleeved on the rotating cushion block 1332 and have a predetermined distance from the rotating cushion block 1332, so that the rotating cushion block 1332 does not drive the heating belt clamping block 1353, the heating member 1352 and the constant temperature seat 1351 to rotate.
As one embodiment, the reaction disk mounting structure 132 has a Wen Yofang cup station area and a purge cup station area. The Wen Yofang cup station area and the cleaning and cup taking station area of the reaction disk mounting structure 132 are fixedly arranged and correspond to the reaction bearing disk 131, the reaction disk driving structure 133 drives the reaction bearing disk 131 to rotate, and the reaction disk driving structure 133 can drive the reaction bearing disk 131 to drive each Wen Yokong 1311 on the reaction bearing disk to move to the corresponding position. The Wen Yofang cup station areas and the cleaning cup taking station areas are respectively arranged corresponding to the cup grabbing mechanisms, and the incubation cup placing station areas are arranged close to incubation cup taking stations of the reaction outer disc mechanism 12 of the incubation device 1, so that the movement path of the reaction cups 2 from the reaction outer disc mechanism 12 to the reaction bearing disc 131 can be reduced; the cleaning cup taking station area is arranged close to the cleaning device, so that the movement path of the reaction cup 2 from the reaction bearing disc 131 to the cleaning device can be reduced, the rapid transfer of the reaction cup 2 is realized, and the operation efficiency of the chemiluminescent detector is improved.
It will be appreciated that the Wen Yofang cup station area and the cleaning and cup taking station area are both areas arranged along the radial direction of the reaction carrier plate 131, and the cup grabbing mechanism can perform corresponding operations on the reaction carrier plate 131 corresponding to the cleaning and cup taking station area in the Wen Yofang cup station area, place the reaction cup 2 in any one of the columns Wen Yokong 1311 corresponding to the Wen Yofang cup station area, and take out the reaction cup 2 in any one of the columns Wen Yokong 1311 corresponding to the cleaning and cup taking station area. If only one circle of incubation holes 1311 is provided on the reaction carrier plate 131, the Wen Yofang cup station area and the cleaning and cup-taking station area are only one location.
Specifically, the reaction disk driving structure 133 drives the reaction carrying disk 131 to rotate to a Wen Yofang cup station area, at this time, a row of Wen Yokong 1311 in the radial direction on the reaction carrying disk 131 corresponds to a Wen Yofang cup station area, and the cup grabbing mechanism can transfer the reaction cup 2 after the sample and the reagent are uniformly mixed to any empty Wen Yokong 1311 at the Wen Yofang cup station area; the reaction disk driving structure 133 drives the reaction carrying disk 131 to rotate to the cleaning and cup taking station area, at this time, a row Wen Yokong 1311 of the reaction carrying disk 131 along the radial direction corresponds to the cleaning and cup taking station area, and the cup grabbing mechanism takes out the reaction cups 2 after incubation at the cleaning and cup taking station area and transfers the reaction cups to the cleaning device.
Optionally, the reaction disk mechanism 13 further includes a temperature monitoring structure disposed on the constant temperature seat 1351, where the temperature monitoring structure can monitor the temperature of the constant temperature seat 1351 to ensure that the temperature of the constant temperature seat 1351 is accurate and reliable, and then ensure that the incubation reaction of the sample proceeds normally. The temperature monitoring structure is used to detect the temperature of the thermostatic seat 1351 and its surroundings. Specifically, the temperature monitoring structure includes a plurality of temperature monitoring components, and the plurality of temperature monitoring components are disposed in different circumferential directions and different radial directions of the constant temperature seat 1351. It will be appreciated that at least two temperature monitoring components are located at different distances from the center of the thermostatic base 1351 and in different radial directions of the thermostatic base 1351. This enables at least two temperature monitoring components to monitor the temperature of the different locations of the thermostatic seat 1351 and the ambient temperature around the thermostatic seat 1351 to ensure that the temperature of the thermostatic seat 1351 is accurate and reliable and that the incubation reaction of the sample is then performed normally. In this embodiment, the plurality of temperature monitoring components include a first temperature monitoring component and a second temperature monitoring component, the first temperature monitoring component and the second temperature monitoring component are both disposed on the constant temperature seat 1351, and the first temperature monitoring component and the second temperature monitoring component are disposed in different circumferential directions and different radial directions of the constant temperature seat 1351, that is, distances from the first temperature monitoring component and the second temperature monitoring component to a center of the constant temperature seat 1351 are different, and are located in different radial directions of the constant temperature seat 1351. The first and second temperature monitoring components are capable of monitoring the temperature of the thermostatic seat 1351 and the temperature of the ambient air. Preferably, the first temperature monitoring component and the second temperature monitoring component are temperature sensors, and of course, in other embodiments of the present invention, the first temperature monitoring component and the second temperature monitoring component may have other structures capable of monitoring temperature.
Further, the reaction disk mechanism 13 further includes a temperature control structure, which is electrically connected to the temperature monitoring structure and the heating element 1352, respectively, and the temperature monitoring structure can feed back the monitored signals of the temperature of the constant temperature seat 1351 and the ambient air temperature to the temperature control structure, and the temperature control structure can control the heating amount of the heating element 1352 according to the received signals. Preferably, the heating element 1352 is an electric heating element, and the temperature control structure can control the current flowing into the electric heating element according to the received signal, so as to adjust the heating amount generated by the electric heating element. Specifically, the first temperature monitoring component and the second temperature monitoring component can monitor the temperature of the constant temperature seat 1351 and the temperature of the surrounding air, and feed back two temperature signals to the temperature control structure, the temperature control structure feeds back and compares the stepped data between the two temperature signals in real time, calculates and controls the current to the heating element 1352, adjusts the current of the heating element 1352, so that the constant temperature seat 1351 forms a stable constant temperature body, ensures the constant temperature around the constant temperature seat 13511, and ensures the heating effect on the reaction carrying disc 131. Optionally, the temperature monitoring structure further includes a heating sensor disposed on the heating member 1352 for detecting a heating temperature of the heating member 1352.
As an embodiment, the reaction plate mechanism 13 further includes a heat insulation structure 136, where the heat insulation structure 136 is disposed around the reaction carrying plate 131 of the heating structure 135, and is used for insulating the reaction carrying plate 131. The heating structure 135 heats the reaction bearing plate 131, the heat insulation structure 136 insulates the reaction bearing plate 131, and the temperature of the reaction bearing plate 131 can be kept constant at about 37 ℃ under the combined action of the heating structure 135 and the heat insulation structure 136, so that the reaction bearing plate 131 is in a better incubation environment, and the incubation effect of the sample is ensured. The heating belt clamp block 1353 can also facilitate the installation of the heat insulation structure 136, so that the heat insulation structure 1353 is stuck to the constant temperature seat 1351 through the heating belt clamp block 1353, and heat dissipation is avoided.
Optionally, referring to fig. 5 and 8, the reaction plate mechanism 13 further includes a thermal cover structure 137, where the thermal cover structure 137 covers the reaction carrier plate 131. The heat preservation cover structure 137 is provided with Wen Yofang cup grooves 13711 and cleaning cup taking grooves 13712. Wen Yofang cup slots 13711 correspond to Wen Yofang cup station areas. The cleaning cup-taking groove 13712 corresponds to the cleaning cup-taking station area. The heat preservation lid structure 137 can greatly reduce the heat and can distribute, and then guarantees that the temperature of reaction bearing plate 131 is invariable, guarantees that reaction plate mechanism 13 is to the incubation effect of sample and reagent in the reaction cup 2. The cup gripping mechanism can place the cuvette 2 in Wen Yokong 1311 at Wen Yofang cup slot 13711 and can also remove the cuvette 2 in incubation well 1311 via washing of the cup removal slot 13712. It can be appreciated that the heat insulation cover structure 137 is fixed on the reaction mounting bottom plate 1321, and the heat insulation cover structure 137 does not rotate along with the rotation of the reaction bearing disc 131, so that the Wen Yofang cup slot 13711 of the heat insulation cover structure 137 always corresponds to the Wen Yofang cup station area, and the cleaning cup taking slot 13712 always corresponds to the cleaning cup taking station area, so that the cup grabbing mechanism is convenient for carrying out cup taking and placing operations. The insulating cover structure 137 and the insulating structure 136 form a relatively airtight environment, so that heat loss is reduced, and the incubation effect of the sample in the reaction carrying tray 131 is ensured. Further, the Wen Yofang cup slots 13711 and the cleaning cup-taking slots 13712 are formed along the radial direction of the reaction carrier plate 131, and correspond to Wen Yokong 1311 of any row of radial directions on the reaction carrier plate 131, so as to facilitate the placement and removal of the reaction cups 2 on the reaction carrier plate 131.
Further, the thermal insulation structure 136 includes bottom thermal insulation cotton 1361 and outer wall thermal insulation cotton 1363, the bottom thermal insulation cotton 1361 is disposed below the heating structure 135, the outer wall thermal insulation cotton 1363 is disposed on the bottom thermal insulation cotton 1361, and the outer wall thermal insulation cotton 1363 is enclosed on the periphery of the reaction carrier disc 131. Further, the thermal insulation structure 136 further includes an inner wall thermal insulation cotton 1362, and the inner wall thermal insulation cotton 1362 is disposed on the bottom thermal insulation cotton 1361 and is located outside the rotating cushion 1332. The bottom thermal insulation cotton 1361 is located under the heating structure 135, i.e. under the heating belt clamping block 1353, and at the same time, the bottom thermal insulation cotton 1361 is adhered to the heating belt clamping block 1353. The inner wall thermal insulation cotton 1362 and the outer wall thermal insulation cotton 1363 are both arranged on the bottom thermal insulation cotton 1361, the inner wall thermal insulation cotton 1362 is positioned in the hollow part of the constant temperature seat 1351 and sleeved with the outer side of the rotary cushion block 1332, and the outer wall thermal insulation cotton 1363 is positioned on the outer side of the reaction bearing disc 131. The inner wall thermal insulation cotton 1362, the bottom thermal insulation cotton 1361 and the outer wall thermal insulation cotton 1363 form a relatively closed and airtight environment with the thermal insulation cover structure 137, so that heat loss is reduced. It will be appreciated that there is some spacing between the inner wall insulation wool 1362 and the rotary spacer 1332 to avoid affecting the rotation of the rotary spacer 1332. Of course, in other embodiments of the present invention, the inner wall thermal insulation cotton 1362, the bottom thermal insulation cotton 1361 and the outer wall thermal insulation cotton 1363 may be made of other thermal insulation materials besides thermal insulation cotton or other thermal insulation structures 136 may be used.
In addition, in this embodiment, the number of the inner wall insulation cotton 1362 and the outer wall insulation cotton 1363 is three, so as to facilitate installation. Three inner wall thermal insulation cotton 1362 are arranged on the bottom thermal insulation cotton 1361 in a stacked manner, and three outer wall thermal insulation cotton 1363 are arranged on the bottom thermal insulation cotton 1361 in a stacked manner. Of course, the number of the inner wall insulation cotton 1362 and the outer wall insulation cotton 1363 may be one, two, four or more. Optionally, insulation 136 also includes insulation 1364, where insulation 1364 is disposed on top of reaction mounting post 1323 to avoid void heat transfer after installation of reaction mounting post 1323 and to avoid heat loss. Preferably, insulation block 1364 is made of a plastic material; of course, it can be made of other materials that can insulate heat.
Specifically, referring to fig. 8 to 10, the insulating cover structure 137 includes a cover 1371 and a cover pillar 1372, and the cover 1371 is disposed on the cover pillar 1372 and covers the reaction carrier plate 131. The lid pillar 1372 wears to establish the rotatory hole of reaction loading tray 131 and is fixed in reaction mounting plate 1321, and lid pillar 1372 still wears to establish hollow rotatory cushion 1332, can avoid rotatory cushion 1332's rotation motion to take place to interfere with lid pillar 1372 like this, guarantees that reaction loading tray 131 rotates steadily reliably. Also, wen Yofang cup slots 13711 and cleaning cup slots 13712 are all located on lid 1371.
Optionally, the insulating cover structure 137 further includes a locking assembly 1373, where the locking assembly 1373 is disposed on the cover 1371 and the cover pillar 1372 to lock the cover 1371 on the cover pillar 1372, so as to ensure that the cover 1371 is reliably covered on the reaction carrier disc 131. Specifically, the locking assembly 1373 includes a locking member 13731 and a locking member 13732, the locking member 13731 is movably disposed on the cover 1371, and the locking member 13732 is fixed on top of the cover pillar 1372. The locking member 13731 can move to the locking member 13732 and cooperate with the locking member 13732 to lock the cover 1371, and at this time, the cover 1371 cannot be removed; the locking member 13731 is disengaged from the locking member 13732, and the cover 1371 is in an unlocked state, at which time the cover 1371 can be removed. Further, the locking assembly 1373 further includes a pulling member 13733, the pulling member 13733 is movably disposed on the cover 1371, the pulling member 13733 is connected to the locking member 13731, and the pulling member 13733 can drive the locking member 13731 to move, so that the locking member 13731 is locked or separated from the locking member 13732. It can be appreciated that the toggle member 13733 can move the locking member 13731, so that the locking member 13731 can cooperate with the locking member 13732 to lock the cover 1371 on the cover post 1372; the toggle member 13733 can also drive the locking member 13731 to move, so that the locking member 13731 can be disengaged from the locking member 13732, and the cover 1371 is unlocked from the cover pillar 1372.
Preferably, the striking member 13733 is a rotating member, and the striking member 13733 includes a locking bar 137332 and an unlocking bar 137331. The locking member 13731 comprises a rotating member 137311 and a locking shaft 137312 connected with the rotating member 137311, and both the locking bar 137332 and the unlocking bar 137331 are connected with the rotating member 137311; the locking member 13732 includes a locking platform 137321 and a protrusion 137322 disposed on the locking platform 137321, and the locking shaft 137312 can be matched with the protrusion 137322 to lock the cover 1371. When the locking bar 137332 moves upwards, the locking bar 137332 drives the locking shaft 137312 to move towards the protrusion 137322 through the rotating piece 137311 and is matched with the protrusion 137322, so that the cover 1371 is locked on the cover pillar 1372; when the unlocking bar 137331 moves upward, the unlocking bar 137331 drives the locking shaft 137312 to disengage from the protrusion 137322 through the rotating member 137311, so as to unlock the cover 1371 from the cover pillar 1372. Alternatively, the locking shaft 137312 is not limited to shaft-like parts, but may be other parts that can be locked in cooperation; the protrusion 137322 is L-shaped to facilitate the locking of the locking shaft 137312, and may be a locking groove formed in the protrusion 137322. Further, the protrusions 137322 are provided with guide slopes to facilitate sliding of the lock shaft 137312 in and out, and to facilitate mating of the lock shaft 137312 with the protrusions 137322. Still further, the protrusion 137322 is integral with the locking platform 137321. In another embodiment of the present invention, the toggle member 13733 may be slidably disposed, so that the toggle member 13733 is slidably disposed, so as to implement the matching between the locking member 13731 and the locking member 13732, thereby facilitating the operation.
Of course, in other embodiments of the present invention, the locking assembly 1373 is a locking screw, and the locking screw can fix the cover 1371 to the cover pillar 1372, so as to prevent the position of the cover 1371 from moving to affect the heat insulation effect. Moreover, the heat preservation cover structure further comprises a holding part, wherein the holding part is positioned above the cover 1371 and protrudes out of the surface of the cover 1371, so that an operator can conveniently take the cover 1371, and the heat preservation cover structure is convenient to operate and use.
Optionally, the insulating cover structure 137 further includes a core cover 1374, the middle area of the cover 1371 is provided with a fixing hole, the stirring member 13733 and the locking member 13731 are installed on the core cover 1374, the core cover 1374 and the cover 1371 enclose an annular groove, and the stirring member 13733 can move into the annular groove to lock and unlock the cover 1371. Specifically, when unlocking bar 137331 is located in the annular groove, locking bar 137332 is located above core cap 1374, at which time cap 1371 is locked to cap post 1372; when locking bar 137332 is located in the annular recess, unlocking bar 137331 is located above core cover 1374, and cover 1371 is unlocked. It can be appreciated that the annular groove can fix the positions of the unlocking bar 137331 and the locking bar 137332, so that the locking and unlocking states of the cover 1371 are ensured to be reliable. Of course, in other embodiments of the present invention, the cover 1371 and the core cover 1374 may be integrally formed, and an annular groove is formed to limit the toggle member 13733.
Moreover, the thermal insulation cover structure 137 further includes a cover sensing member and a cover sensing member, the cover sensing member is disposed on the cover 1371, and the cover sensing member is disposed on top of the cover pillar 1372. The cover detecting piece can detect the position of the cover body sensing piece so as to determine whether the heat preservation cover is covered. It can be appreciated that the cover sensing element can sense the cover sensing element, and the cover 1371 is shown to be covered on the reaction carrying disc 131; if the detecting cover cannot sense the cover sensing member, it indicates that the cover 1371 is far away from the reaction carrier plate 131 or that the cover 1371 is not well covered on the reaction carrier plate 131. Preferably, the cover measuring member is a cover measuring sensor, and the cover sensing member is a sensing magnet; of course, in other embodiments of the present invention, the detecting cover and the cover sensing member may be other matching structures capable of realizing whether the cover 1371 is covered. The insulating cover structure 137 further includes core insulating cotton 1378, where the core insulating cotton 1378 is disposed between the inner side of the rotary spacer 1332 and the cover pillars 1372 to prevent heat loss from between the cover 1371 and the reaction carrier plate 131. Preferably, the number of the core thermal insulation cottons 1378 is at least one, so that the core thermal insulation cottons 1378 fill up the space in the height direction inside the rotary cushion 1332, and the thermal insulation effect is ensured. In this embodiment, the number of core insulating cottons 1378 is three to facilitate installation. Three core insulating cottons 1378 are stacked on the inner side of the rotary pad 1332. Of course, the number of core insulating cottons 1378 may also be one, two, four or even more.
Optionally, the insulating cover structure 137 further includes a fixing component 1377, where the fixing component 1377 connects the insulating structure 136 and the cover 1371, and the fixing component 1377 can fix the cover 1371 on the insulating cotton 1363 on the outer wall of the insulating structure 136. The specific fixed subassembly 1377 includes annular outer briquetting 13771 and guide pin 13772, and annular outer briquetting 13771 sets up between lid 1371 and outer wall insulation cotton 1363, and annular outer briquetting 13771 can guarantee the leakproofness between lid 1371 and the outer wall insulation cotton 1363, avoids heat to run off between lid 1371 and outer wall insulation cotton 1363. Moreover, a guide mounting groove is formed in the cover 1371, and the guide pin 13772 penetrates through the guide mounting groove and is mounted on the annular outer pressing block 13771, so that the cover 1371 is connected with the annular outer pressing block 13771, and the cover 1371 and the annular outer pressing block 13771 are ensured to be fixed and reliable. Optionally, the insulating cover structure 137 further includes an annular inner pressing block 13773, where the annular inner pressing block 13773 is disposed between the cover 1371 and the inner wall insulating cotton 1362, for limiting the degree of freedom of the inner wall insulating cotton 1362 to upwards move, and ensuring tightness between the cover 1371 and the inner wall insulating cotton 1362, so as to avoid heat loss between the cover 1371 and the inner wall insulating cotton 1362. Optionally, the number of cover posts 1372 is at least two, which can ensure that core cover 1374 is securely fastened to reaction mounting plate 1321, which in turn ensures that cover 1371 is securely fastened to reaction mounting plate 1321.
Optionally, the insulating cover structure 137 further includes an observation cover 1379, and an observation window is further formed on the cover 1371, where the observation cover 1379 is switchably located in the observation window of the cover 1371, so as to facilitate an operator to observe the operation condition in the reaction carrier disc 131, and facilitate manual cleaning of the reaction cup 2. In this embodiment, one end of the viewing cover 1379 is rotatably fixed to the cover 1371, and the other end of the viewing cover 1379 can be rotated around one end of the viewing cover 1379 to open or close the viewing window. Optionally, the thermal insulation cover structure 137 further includes a turnbuckle, and the other end of the observation cover 1379 is screwed on the cover 1371 through the turnbuckle. When viewing is desired, the turnbuckle is turned on to enable the viewing cover 1379 to be opened; when observation is not required, the knob can fix the observation lid 1379 to the lid 1371, and the observation lid 1379 is prevented from being opened at will. Of course, in another embodiment of the present invention, the viewing cover 1379 may be a transparent window to facilitate direct viewing, and in this case, the viewing cover 1379 and the cover 1371 are integrally formed. In another embodiment of the present invention, the entire cover 1371 is made of transparent material. That is, the cover 1371 is transparent, and at this time, the operator can directly observe the operation condition of the entire reaction carrier plate 131 through the transparent cover 1371 without providing the observation cover 1379 on the cover 1371.
Optionally, the reaction disk mechanism 13 further includes a reaction detecting structure 134, where the reaction detecting structure 134 is disposed on the rotating platform 1331, and the reaction detecting structure 134 is capable of detecting an initialization position of the reaction carrier disk 131. The reaction detecting structure 134 includes a reaction detecting member 1341 and a reaction sensing member 1342, the reaction detecting member 1341 is disposed on the rotary platform 1331, and the reaction sensing member 1342 is mounted on the rotor. The reaction sensing piece 1342 can cooperate with the reaction detecting piece 1341 to detect the initial position of the reaction carrying disc 131, so as to facilitate the initial positioning of the reaction carrying disc 131. In this embodiment, the reaction detecting member 1341 may be a detecting optocoupler, and the reaction sensing member 1342 may be an optocoupler sensing piece; of course, in other embodiments of the present invention, the reaction detecting member 1341 and the reaction sensing member 1342 may be hall switches or other components capable of detecting positions. It can be appreciated that the reaction sensing member 1342 and the reaction detecting member 1341 detect the initial position of the reaction carrier plate 131 by controlling the rotating platform 1331, so that the rotating platform 1331 can be at the initial position, and the position of the reaction carrier plate 131 can be accurately monitored by the number of steps of the rotating platform 1331, so that the movement of the reaction carrier plate 131 is accurate and reliable.
Referring to fig. 1 to 3, the invention further provides an incubation device 1 capable of carrying empty reaction cups 2, samples and reagents are respectively added into the reaction cups 2 at the incubation device 1, and the adding action, the mixing action and the incubation action of the samples and the reagents are respectively carried out at different positions, so that the mutual operations cannot interfere, each operation can be carried out simultaneously, the problems of long operation time caused by the occupied time and the occupied large space when each section of working procedure of the current sample reaction is carried out are effectively solved, the operation efficiency of the incubation device 1 is ensured, the detection speed of a chemiluminescent detector is improved, and the detection efficiency is further ensured.
In the present invention, the incubation apparatus 1 includes a buffer tray mechanism 11, a reaction outer tray mechanism 12, and a reaction tray mechanism 13 in the above-described embodiment. The buffer tray mechanism 11 can carry empty cuvettes 2, and the empty cuvettes 2 can perform a sample addition operation on the buffer tray mechanism 11. Specifically, an empty cuvette 2 is transferred to the buffer tray mechanism 11, and then the sample loading device of the chemiluminescent detector is able to transfer the sample into the cuvette 2 above the buffer tray mechanism 11. The reaction cup 2 with the added sample can be carried by the reaction outer disc mechanism 12, and the reaction cup 2 with the added sample performs reagent adding operation and mixing operation on the reaction outer disc mechanism 12. Specifically, the reaction cup 2 with the sample added on the buffer disk mechanism 11 is transferred to the reaction outer disk mechanism 12, then, the reagent adding device of the chemiluminescent detector can transfer the reagent to the reaction cup 2 with the sample added on the reaction outer disk mechanism 12, and then, the mixing device of the chemiluminescent detector can mix the reaction cup 2 with the sample and the reagent, so that the sample and the reagent are mixed uniformly. The reaction disk mechanism 13 is capable of carrying the cuvette 2 after mixing and incubating the sample in the cuvette 2 with the reagent. Specifically, the reaction cup 2 in the reaction outer disc mechanism 12 can be transferred to the reaction disc mechanism 13, and then, the reaction disc mechanism 13 can incubate the uniformly mixed sample and the reagent in the reaction cup 2, so that the sample reaches the optimal reaction condition, and the sample parameters can be conveniently detected by the luminescence detection device of the chemiluminescent detector.
The buffer tray mechanism 11 comprises a rotatable buffer carrier tray, and the buffer carrier tray can accommodate the cuvette 2 and enable the cuvette 2 to finish the sample adding operation on the buffer carrier tray. The reaction outer disk mechanism 12 includes a rotatable reaction outer disk carrier disk 121, and the reaction outer disk carrier disk 121 is capable of accommodating the cuvette 2 transferred from the buffer disk mechanism 11 and enabling the cuvette 2 to perform reagent adding operation and mixing operation on the reaction outer disk mechanism 12. The reaction disk 131 of the reaction disk mechanism 13 is capable of accommodating the cuvette 2 transferred from the reaction disk 121 and of performing an incubation operation of the cuvette 2 on the reaction disk mechanism 13. The buffer carrier, the reaction outer disk carrier 121, and the reaction carrier 131 can be rotated independently.
The empty reaction cup 2 is transferred to the buffer bearing disc, and then the sample adding device adds samples to the reaction cup 2 above the buffer bearing disc; after the addition of the sample is completed, the reaction cup 2 with the sample is transferred to the reaction outer disc bearing disc 121, the reagent adding device adds a reagent into the reaction cup 2 with the sample in the reaction outer disc bearing disc 121, and after the reagent addition is completed, the mixing device carries out mixing operation on the reaction cup 2 in the reaction outer disc bearing disc 121, so that the sample and the reagent are uniformly mixed; after the completion of the mixing, the cuvette 2 after the sample and the reagent are mixed uniformly is transferred to the reaction carrier plate 131, and an incubation operation is performed in the reaction carrier plate 131, and after the incubation operation is completed, the cuvette 2 in the reaction carrier plate 131 is transferred away for the next operation. It will be appreciated that the empty cuvette 2 is transferred from the cuvette 2 automatic transfer device of the chemiluminescent detector to the buffer carrier plate, however, in other embodiments of the present invention, the empty cuvette 2 may be loaded from outside the chemiluminescent detector, so long as it is ensured that the empty cuvette 2 is transported to the buffer carrier plate to meet the requirements.
It should be noted that, the rotatable setting of buffering loading tray can make things convenient for empty reaction cup 2 to shift to reaction outer dish loading tray 121 for the buffering loading tray needs to place the cup position that adds of reaction cup 2 and is close to the automatic transmission device department of reaction cup 2 of chemiluminescent detector, can reduce the reaction cup 2 like this from the automatic transmission device of reaction cup 2 to the motion distance of buffering loading tray, improves the transfer rate of reaction cup 2. In addition, the buffer bearing disc can also drive the reaction cup 2 to be added with the sample to move towards the sample adding position of the sample adding device, so that the efficiency of sample adding of the sample adding device into the reaction cup 2 of the buffer bearing disc can be improved; in addition, the reaction cup 2 with the added sample in the buffer bearing plate can also move towards the direction approaching to the reaction outer plate bearing plate 121, so that the moving distance of the reaction cup 2 with the added sample from the buffer bearing plate to the reaction outer plate bearing plate 121 can be reduced, and the transfer speed of the reaction cup 2 can be improved. The reaction outer disc bearing disc 121 can be rotatably arranged to facilitate the reaction outer disc bearing disc 121 to move to different positions, and operations such as cup adding (i.e. loading the reaction cup 2 after the sample is added), reagent adding, mixing and cup taking (i.e. transferring away the reaction cup 2 after mixing) are respectively executed at corresponding positions, so that the reaction cups 2 at all positions can simultaneously execute corresponding operations, and the operation efficiency of the reaction outer disc bearing disc 121 is improved. The rotatable arrangement of the reaction carrier plate 131 can enable the position of the reaction carrier plate 131 where the reaction cup 2 needs to be placed to be close to the cup taking position of the reaction outer plate carrier plate 121, so that the transfer path of the reaction cup 2 is reduced. Through the cooperation of rotatable buffering loading tray, rotatable reaction outer dish loading tray 121 and rotatable reaction loading tray 131, can improve the motion efficiency of instrument, and then guarantee detection efficiency.
The buffer carrier, the reaction outer disk carrier 121, and the reaction carrier 131 are rotatable independently of each other. It will be appreciated that the movements of the buffer carrier disc, the reaction outer disc carrier disc 121 and the reaction carrier disc 131 do not interfere with each other, and the buffer carrier disc does not affect the cup filling and reagent filling operation of the reaction outer disc carrier disc 121 and the incubation cup filling and cup taking operation of the reaction carrier disc 131 when the cup filling and sample filling operations are performed. Namely, the buffer bearing disc needs to be in a static state when the cup is empty and the sample is added, at this time, the reaction outer disc bearing disc 121 can be in a rotating state, and the reaction bearing disc 131 can also be in a rotating state; the reaction outer tray carrier 121 needs to be in a static state when performing the operations of adding a cup, adding a reagent, mixing uniformly and taking a cup, and at this time, the buffer carrier may be in a rotating state, and the reaction carrier 131 may also be in a rotating state; the reaction carrier plate 131 needs to be in a static state when adding and taking cups, and at this time, the buffer carrier plate can be in a rotating state, and the reaction outer plate carrier plate 121 can also be in a rotating state. In this way, the respective functions of the incubation device 1 are allocated to the buffer carrier tray, the reaction outer tray carrier tray 121 and the reaction carrier tray 131, and the buffer carrier tray, the reaction outer tray carrier tray 121 and the reaction carrier tray 131 can perform the corresponding actions, respectively, without waiting for the previous operation, so that the operations on the buffer carrier tray, the reaction outer tray carrier tray 121 and the reaction carrier tray 131 are performed simultaneously, the speed of incubating the sample by the incubation device 1 is increased, and the running time of the incubation device 1 in incubating the sample is shortened.
When the incubation device 1 of the present invention is in operation, the empty reaction cup 2 is transferred to the buffer carrying tray of the buffer tray mechanism 11, and a sample is added to the empty reaction cup 2, then the reaction cup 2 to which the sample is added is transferred from the buffer carrying tray to the reaction outer tray carrying tray 121 of the reaction outer tray mechanism 12, and a reagent is added to the reaction cup 2 of the reaction outer tray carrying tray 121, and a mixing operation is performed; the reaction cup 2 after mixing is transferred from the reaction outer disc bearing disc 121 to the reaction bearing disc 131 of the reaction disc mechanism 13, the operation of incubation of the reaction cup 2 after mixing is completed on the reaction bearing disc 131, and as the buffer bearing disc, the reaction outer disc bearing disc 121 and the reaction bearing disc 131 rotate independently, the buffer bearing disc can carry out the operations of adding a cup, adding a reagent, mixing, taking a cup and the like when the buffer bearing disc carries out the operations of adding a cup and a sample, the reaction bearing disc 131 can carry out the operations of adding a cup and taking a cup, the operations of the reaction bearing disc 131 can be carried out simultaneously without interference, the problems of long operation time caused by the occupied time and the occupied large space when each section of procedure of the current sample reaction is carried out are effectively solved, the detection speed of a chemiluminescent detector is improved, and the detection efficiency is further ensured.
Further, the reaction outer disk carrier 121 has a circular ring shape, and the reaction carrier 131 has a disk shape. The reaction outer tray carrier 121 is sleeved outside the reaction carrier 131, and the buffer carrier is independent of the reaction outer tray carrier 121. The reaction carrier plate 131 is positioned at the inner side of the reaction outer plate carrier plate 121, so that the distance of transferring the reaction cups 2 in the reaction outer plate carrier plate 121 to the reaction carrier plate 131 can be reduced; at the same time, the space occupied by the reaction outer tray carrier 121 and the reaction carrier 131 can be reduced, so that the volume of the chemiluminescent detector can be reduced. Moreover, the buffer bearing plate is independent of the reaction outer plate bearing plate 121 and the reaction bearing plate 131, so that sample adding operation and reagent adding and incubation operation of samples are separated, the buffer plate mechanism 11, the reaction outer plate mechanism 12 and the reaction plate mechanism 13 are arranged conveniently, and meanwhile, the movement of the buffer bearing plate, the reaction outer plate bearing plate 121 and the reaction bearing plate 131 and the movement of devices, such as a sample adding device, a reagent adding device and the like, for executing corresponding operations by matching the buffer bearing plate, the reaction outer plate bearing plate 121 and the reaction bearing plate 131 can be prevented from being interfered. The buffer carrier plate may have a disk shape, or may have an elliptical shape, a quadrangular shape, or another shape capable of carrying the cuvette 2.
In still another embodiment of the present invention, the reaction outer tray 121 is sleeved outside the reaction outer tray 131, and the buffer tray is sleeved outside the reaction outer tray 121. It can be understood that the buffer bearing disc, the reaction outer disc bearing disc 121 and the reaction bearing disc 131 are arranged in a layer-by-layer sleeved mode, the buffer bearing disc is located at the outermost side, the reaction bearing disc 131 is located at the innermost side, and the reaction cup 2 is transferred onto the buffer bearing disc, then onto the reaction outer disc bearing disc 121 and then onto the reaction bearing disc 131. Therefore, the moving path of the transfer of the reaction cup 2 can be reduced, the detection efficiency is improved, the space occupied by the incubation device 1 can be greatly reduced, the internal space of the chemiluminescent detector is saved, and the whole volume is further reduced. Of course, in other embodiments of the present invention, the buffer carrier plate, the reaction outer plate carrier plate 121 and the reaction carrier plate 131 are separately provided. It is understood that the buffer carrier plate, the reaction outer plate carrier plate 121 and the reaction carrier plate 131 may be arranged in a straight line, a delta shape or other forms, so long as the operations on the buffer carrier plate, the reaction outer plate carrier plate 121 and the reaction carrier plate 131 can be performed independently, the operation time of the incubation device 1 of the present invention can be shortened, and the purpose of improving the detection efficiency can be achieved.
Further, the axis of the reaction outer disk carrier disk 121 coincides with the axis of the reaction carrier disk 131. It will be appreciated that when the reaction outer tray 121 is sleeved on the outer side of the reaction outer tray 131, the axis of the reaction outer tray 121 coincides with the axis of the reaction outer tray 131, so that the space occupied by the reaction outer tray 121 and the reaction outer tray 131 can be reduced, and the volume of the incubation device 1 can be reduced.
Still further, the top surface of the reaction outer tray carrier tray 121 is in the same plane as the top surface of the reaction carrier tray 131. So can make things convenient for the transfer of reaction cup 2, avoid reaction cup 2 to interfere with the top surface of reaction outer dish carrier disc 121 or the top surface of reaction carrier disc 131 when transferring, guarantee the reliability that reaction cup 2 shifted, and then guarantee the performance of chemiluminescent detector. Of course, in other embodiments of the present invention, the top surface of the reaction outer tray carrier tray 121 is in a plane lower or higher than the plane of the top surface of the reaction carrier tray 131.
The invention also provides a chemiluminescent detector which comprises an automatic transmission device of the reaction cup 2, a sample adding device, a cleaning device, a luminescent detection device, a control device and the incubation device 1 in the embodiment. The control device transfers the reaction cup 2 in the automatic reaction cup 2 box conveying device into the incubation device 1, the control device controls the sample adding device to add samples to the reaction cup 2 in the incubation device 1, and after incubation is completed, the control device controls the reaction cup 2 to be sequentially transferred into the cleaning device and the luminescence detection device. According to the chemiluminescent detector disclosed by the invention, the incubation operation steps of the sample can be carried out in a zoned manner through the incubation device 1, so that the functions of the incubation device 1 are organically distributed, each step can be carried out simultaneously, the problem that the operation time is long due to the fact that each step of the traditional sample reaction occupies time and occupies a large space when the steps are carried out is solved, the processing time of the sample on the incubation device 1 is shortened, the processing efficiency of the sample is improved, the incubation processing efficiency of the sample is further improved, and the detection efficiency of the whole chemiluminescent detector is improved. Meanwhile, the arrangement of the incubation device 1 can save space, so that the incubation device 1 can realize high-speed and high-precision operation on the premise of not occupying excessive space, and simultaneously, the huge production of the incubation device 1 and the whole machine can be avoided, so that the whole machine size of the chemiluminescent detector is ensured.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be regarded as the description scope of the present specification.
The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (28)
1. A reaction disk mechanism, comprising:
A rotatable reaction carrying disk capable of accommodating the reaction cup; and
The heating structure comprises a constant temperature seat and a heating piece, wherein the constant temperature seat is arranged below the reaction bearing disc, the heating piece is arranged below the constant temperature seat, and the heating piece heats the constant temperature seat and heats the reaction cup in the reaction bearing disc through the constant temperature seat;
The constant temperature seat comprises a constant temperature bottom plate and a plurality of constant temperature baffles arranged on the constant temperature bottom plate, the plurality of constant temperature baffles are sleeved layer by layer, a plurality of constant temperature grooves are formed between two adjacent constant temperature baffles, a plurality of circulation grooves or circulation holes are formed in each constant temperature baffle, and the circulation grooves or the circulation holes are communicated with any two adjacent constant temperature grooves;
the Wen Yokong of the reaction carrying tray is arranged corresponding to the constant temperature groove, and any two adjacent Wen Yokong of the reaction carrying tray in the radial direction are respectively positioned in the two adjacent constant temperature grooves.
2. The reaction plate mechanism of claim 1 wherein a predetermined gap exists between the thermostatic seat and the reaction carrier plate, the reaction carrier plate being capable of causing an air flow to flow in the predetermined gap when rotated relative to the thermostatic seat.
3. The reaction disk mechanism of claim 1, wherein the reaction carrier disk is disk-shaped, the thermostatic base plate is disk-shaped, the plurality of thermostatic baffles are ring-shaped, and a circular thermostatic bath is formed between two adjacent thermostatic baffles.
4. A reaction disk mechanism according to claim 3, wherein the number of Wen Yokong is plural, a plurality of Wen Yokong are arranged in a row in the radial direction of the reaction carrier disk, and a plurality of Wen Yokong are distributed in a ring shape at equal radii.
5. The reaction disk mechanism of claim 4 wherein said Wen Yokong circumferentially adjacent reaction carrier disks are each located in a corresponding one of said thermostats.
6. The reaction disk mechanism of any one of claims 1 to 5 wherein the heating structure further comprises a heating band clamp block disposed below a heating element, the heating band clamp block capable of securing the heating element to the thermostatic seat.
7. A reaction plate mechanism according to claim 3, further comprising a temperature monitoring structure disposed on the thermostatic seat, the temperature monitoring structure being capable of monitoring the temperature of the thermostatic seat.
8. The reaction disk mechanism of claim 7 wherein the temperature monitoring structure comprises a plurality of temperature monitoring components, the plurality of temperature monitoring components being disposed along different circumferential directions and different radial directions of the thermostatic seat.
9. The reaction disk mechanism of claim 8 further comprising a temperature control structure electrically connected to the temperature monitoring structure and the heating element, respectively, the temperature monitoring structure being capable of feeding back signals of the temperature of the thermostat base and the ambient air temperature to the temperature control structure, the temperature control structure being capable of controlling the heating value of the heating element based on the received signals.
10. The reaction disk mechanism of claim 9 wherein the heating element is an electrical heating element and the temperature control structure is capable of controlling the magnitude of the current supplied to the electrical heating element in response to the received signal.
11. The reaction disk mechanism of claim 4 further comprising a reaction disk mounting structure and a reaction disk drive structure drivingly connected to the reaction carrier disk;
the reaction disk driving structure is arranged on the reaction disk mounting structure, and drives the reaction bearing disk to rotate relative to the reaction disk mounting structure.
12. The reaction disk mechanism of claim 11, wherein the reaction disk drive structure comprises a rotary platform and a rotary spacer, a rotary hole is formed in a middle region of the reaction carrier disk, the rotary spacer is installed in the rotary hole and connected with the reaction carrier disk, the rotary platform is connected with the rotary spacer, and the rotary platform drives the rotary spacer to drive the reaction carrier disk to rotate.
13. The reaction plate mechanism of claim 12, further comprising a thermal insulation structure surrounding the reaction plate, and wherein the heating structure is disposed between the thermal insulation structure and the reaction plate, the thermal insulation structure being configured to insulate the reaction plate.
14. The reaction tray mechanism of claim 13, wherein the thermal insulation structure comprises bottom thermal insulation cotton and outer wall thermal insulation cotton, the bottom thermal insulation cotton is disposed below the heating structure, the outer wall thermal insulation cotton is disposed on the bottom thermal insulation cotton, and the outer wall thermal insulation cotton is disposed around the periphery of the reaction carrier tray.
15. The reaction plate mechanism of claim 14, wherein the insulating structure further comprises an inner wall insulating cotton disposed on the bottom insulating cotton and outside the rotating pad.
16. The reaction disk mechanism of claim 15 further comprising a thermal cover structure for covering the reaction carrier disk, the thermal cover structure comprising a cover and cover posts supporting the cover, the cover posts being disposed on the reaction disk mounting structure, the cover posts supporting the cover on the reaction disk mounting structure.
17. The reaction disk mechanism of claim 16 wherein the insulating cover structure further comprises a viewing cover having a viewing window formed therein, the viewing cover being switchably located within the viewing window of the cover.
18. The reaction disk mechanism of claim 16 wherein said cover defines a Wen Yofang cup slot and a rinse cup-taking slot, said reaction disk mounting structure having an incubation cup-placing station area and a rinse cup-taking station area, said Wen Yofang cup slot corresponding to said Wen Yofang cup station area, said rinse cup-taking slot corresponding to said rinse cup-taking station area, a cup-grasping mechanism capable of placing a reaction cup in said Wen Yokong at said Wen Yofang cup slot and also capable of removing said reaction cup in said Wen Yokong through said rinse cup-taking slot.
19. The reaction disk mechanism of claim 18 wherein the Wen Yofang cup slots and the purge cup slots extend in a radial direction of the reaction carrier disk and correspond to any one of the rows of Wen Yokong arranged in a radial direction.
20. The reaction disk mechanism of claim 16 wherein the insulating cover structure further comprises a locking assembly disposed on the cover and the cover support, the locking assembly capable of locking the cover to the cover support.
21. The reaction disk mechanism of claim 20 wherein the locking assembly comprises a locking member movably disposed on the cover and a locking member secured to the top of the cover post, the locking member cooperating with the locking member to lock the cover to the cover post.
22. The reaction plate mechanism of claim 21 wherein the locking assembly further comprises a toggle member movably disposed on the cover, the toggle member being coupled to the locking member, the toggle member being capable of moving the locking member to lock or unlock the locking member.
23. The reaction disk mechanism of claim 16 wherein the thermal cover structure further comprises a cover sensing member and a cover sensing member, the cover sensing member being disposed on the cover post, the cover sensing member being disposed on the cover, the cover sensing member being capable of detecting the position of the cover sensing member.
24. The reaction disk mechanism of claim 16 wherein the insulating cover structure further comprises a securing assembly connecting the insulating structure to the cover, the securing assembly being capable of securing the cover to the insulating structure.
25. The reaction disk mechanism of claim 24 wherein the securing assembly comprises an annular outer press block disposed between the cover and the outer wall insulation wool and a guide pin disposed through the cover and mounted in the annular outer press block; the fixing assembly further comprises an annular inner pressing block, and the annular inner pressing block is arranged between the inner wall heat insulation cotton and the cover body.
26. An incubation apparatus comprising a buffer tray mechanism, a reaction outer tray mechanism, and a reaction tray mechanism according to any one of claims 1 to 25;
The buffer disc mechanism comprises a rotatable buffer bearing disc, wherein the buffer bearing disc can accommodate a reaction cup and can enable the reaction cup to finish sample adding operation on the buffer bearing disc;
The reaction outer disc mechanism comprises a rotatable reaction outer disc bearing disc, and the reaction outer disc bearing disc can accommodate the reaction cup transferred from the buffer disc mechanism and can enable the reaction cup to finish the reagent adding operation and the mixing operation on the reaction outer disc mechanism;
the reaction tray of the reaction tray mechanism is capable of accommodating the reaction cups transferred from the reaction outer tray and of performing an incubation operation on the reaction tray mechanism;
the buffer bearing disc, the reaction outer disc bearing disc and the reaction bearing disc can rotate independently.
27. The incubation device of claim 26 wherein the reaction outer tray is circular and the reaction tray is disk-shaped;
the reaction outer disc bearing disc is sleeved on the outer side of the reaction bearing disc, and the buffer bearing disc is independent of the reaction outer disc bearing disc.
28. A chemiluminescent detector comprising a cuvette automatic transfer device, a sample addition device, a wash device, a luminescent detection device, a control device, and an incubation device according to any one of claims 26-27;
The control device transfers the reaction cups in the automatic reaction cup conveying device to the incubation device, controls the sample adding device to add samples to the reaction cups in the incubation device, and controls the reaction cups to be sequentially transferred to the cleaning device and the light-emitting detection device after incubation is completed.
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| CN110333117A (en) * | 2019-06-26 | 2019-10-15 | 万兆 | Cytological stains machine |
| CN110333119A (en) * | 2019-06-26 | 2019-10-15 | 万兆 | Lid-moving machine structure and cytological stains machine with it |
| CN110333118A (en) * | 2019-06-26 | 2019-10-15 | 万兆 | Incubate device and the cytological stains machine with it |
| EP4143583B1 (en) * | 2020-04-30 | 2024-02-14 | Diasys Technologies S.A.R.L. | Apparatus for the automated diagnostic analysis of liquid samples |
| CN111812340B (en) * | 2020-05-29 | 2022-07-15 | 杭州龙鑫科技有限公司 | Temperature raising disc mechanism of full-automatic urine specific protein analyzer |
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| CN207472774U (en) * | 2017-09-29 | 2018-06-08 | 深圳市新产业生物医学工程股份有限公司 | Chemiluminescence detector and its incubation device |
| CN109580594A (en) * | 2017-09-29 | 2019-04-05 | 深圳市新产业生物医学工程股份有限公司 | Chemiluminescence detector incubates device and reaction disc mechanism |
| CN109580596A (en) * | 2017-09-29 | 2019-04-05 | 深圳市新产业生物医学工程股份有限公司 | Chemiluminescence detector incubates device and its Incubation methods |
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