CN109528550A - A kind of dissolving method of sodium hyaluronate for solution preparation - Google Patents

A kind of dissolving method of sodium hyaluronate for solution preparation Download PDF

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CN109528550A
CN109528550A CN201811609363.XA CN201811609363A CN109528550A CN 109528550 A CN109528550 A CN 109528550A CN 201811609363 A CN201811609363 A CN 201811609363A CN 109528550 A CN109528550 A CN 109528550A
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water
sodium hyaluronate
soluble
solid mixture
dissolving method
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CN109528550B (en
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束伟霞
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HYDRON CONTACT LENS CO Ltd
JIANGSU HORIEN CONTACT LENS CO Ltd
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HYDRON CONTACT LENS CO Ltd
JIANGSU HORIEN CONTACT LENS CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/722—Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C11D3/042—Acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C11D3/046—Salts
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
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    • C11D3/22—Carbohydrates or derivatives thereof
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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Abstract

The present invention provides a kind of dissolving methods of sodium hyaluronate for solution preparation, belong to feed liquid preparation technique field.The present invention first mixes the water-soluble solid substance in product formula with sodium hyaluronate, obtains solid mixture, then the remaining ingredient being dissolved in the water is mixed with solid mixture, until solid mixture is completely dissolved.The present invention can carry out physical dispersion to sodium hyaluronate using original water-soluble solid substance in product formula, be allowed to be not easy to assemble in water to unite, to better disperse dissolution.Dissolving method provided by the invention can quickly dissolve sodium hyaluronate, to improve production efficiency, accelerate procedure for producing；The invention avoids long agitations to lead to the problem of more foam simultaneously, reduces contamination of products, rotten or unstable risk；Dissolving method provided by the invention is easily operated, the production suitable for industrial mass.

Description

A kind of dissolving method of sodium hyaluronate for solution preparation
Technical field
The present invention relates to feed liquid preparation technique field, in particular to a kind of dissolving method of sodium hyaluronate for solution preparation.
Background technique
Sodium hyaluronate (Sodium Hyaluronate) is a kind of acidic mucopolysaccharide, by D-Glucose aldehydic acid and N-acetyl The sodium salt for the glycosaminoglycan that base-D- Glucosamine dissacharide units are constituted, molecular formula are (C14H20N NaO11) n, structure such as formula Shown in 1:
Sodium hyaluronate is usually that white or off-white color particle or powder, odorless have moisture-keeping function.It can be applied to all kinds of The adjuvant drugs such as ophthalmologic operation, treatment of arthritis and accelerating wound healing；It can be applied to frost, facial mask, shampoo of cosmetics etc. In product, to keep the moisture of skin, hair, skin care and hair；It can be applied in contact lens care products, rises and protects Wet lubricating action increases water-retaining property.Sodium hyaluronate can be used as cosmetics (lotion, toner etc.), contact lens care products, drop One of material compositions such as ocular fluid.
Since sodium hyaluronate is water-soluble sodium salt, general dissolving method is to direct plunge into sodium hyaluronate in water, It is stirred dissolution.However, general dissolving method has the disadvantage that
(1) dissolution time is long, so that feed liquid is prepared, time-consuming, influences the progress of procedure for producing；
(2) prolonged stirring generates more foam, increases the exposure level with oxygen, increases product contaminated Or the risk that microbiological contamination is rotten, lead to unstable product quality；
(3) prolonged stirring increases foam, influences feed liquid filling speed, reduces production efficiency；A large amount of foams are deposited Also the accuracy of filling amount is being influenced；
(4) prolonged stirring can generate heat, and sodium hyaluronate belongs to heat labile product, and temperature rising can make glass Sour sodium molecule decomposes, and leads to unstable product quality.
Summary of the invention
In view of this, it is an object of that present invention to provide a kind of dissolving methods of sodium hyaluronate for solution preparation.The present invention provides Dissolving method the rate of dissolution of sodium hyaluronate can be improved, shorten liquid preparation time, and reduce bubble content.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
A kind of dissolving method of sodium hyaluronate for solution preparation, comprising the following steps:
(1) the water-soluble solid substance in product formula is mixed with sodium hyaluronate, obtains solid mixture；The product For the liquid form product in formula including water-soluble solid substance and sodium hyaluronate；
(2) remaining ingredient in product formula is dissolved in the water, obtains mixed liquor；
(3) solid mixture is mixed under stirring conditions with mixed liquor, until solid mixture is completely dissolved；
The limitation of the not no time sequencing in the step (1) and (2).
Preferably, the product in the step (1) is cosmetic emulsion, toner, contact lens care solution or eye drops.
Preferably, water-soluble solid substance is water soluble salt and/or water-soluble solid acid, the water in the step (1) Soluble is one or more of chlorate, phosphate, sulfate, borate, citrate and edetate, described water-soluble Property solid acid be one or more of boric acid, citric acid and tartaric acid.
Preferably, the mass ratio of sodium hyaluronate and water-soluble solid substance is 1:1~50 in the step (1).
Preferably, the rate stirred in the step (3) is 150~650r/min.
The present invention provides a kind of dissolving method of sodium hyaluronate for solution preparation, the present invention first will be water-soluble in product formula Property solid matter is mixed with sodium hyaluronate, obtains solid mixture, then by the remaining ingredient being dissolved in the water and solid mixture It is mixed, until solid mixture is completely dissolved.The present invention, can be with using original water-soluble solid substance in product formula Physical dispersion is carried out to sodium hyaluronate, is allowed to be not easy to assemble in water to unite, to better disperse dissolution.It is provided by the invention Dissolving method can quickly dissolve sodium hyaluronate, to improve production efficiency, accelerate procedure for producing；The invention avoids length simultaneously Time stirring leads to the problem of more foam, reduces contamination of products, rotten or unstable risk；Dissolution provided by the invention Method is easily operated, the production suitable for industrial mass.Embodiment the result shows that, dissolving method provided by the invention can be fast Instant solution sodium hyaluronate, dissolution time compared to individually dissolution sodium hyaluronate substantially reduce, and resulting solution clarify, bubble compared with It is few.
Specific embodiment
The present invention provides a kind of dissolving methods of sodium hyaluronate for solution preparation, comprising the following steps:
(1) the water-soluble solid substance in product formula is mixed with sodium hyaluronate, obtains solid mixture；The product For the liquid form product in formula including water-soluble solid substance and sodium hyaluronate；
(2) remaining ingredient in product formula is dissolved in the water, obtains mixed liquor；
(3) solid mixture is mixed under stirring conditions with mixed liquor, until solid mixture is completely dissolved；
The limitation of the not no time sequencing in the step (1) and (2).
The present invention mixes the water-soluble solid substance in product formula with sodium hyaluronate, obtains solid mixture.At this In invention, the product is the liquid form product in formula including water-soluble solid substance and sodium hyaluronate, preferably cosmetics cream Liquid, toner, contact lens care solution or eye drops；The water-soluble solid substance is preferably water soluble salt and/or water solubility Solid acid, the water soluble salt are preferably one in chlorate, phosphate, sulfate, borate, citrate and edetate Kind is several, and the water-soluble solid acid is preferably one or more of boric acid, citric acid and tartaric acid.
In the present invention, the mass ratio of the sodium hyaluronate and water-soluble solid substance is preferably 1:1~50, more preferably 1:10~30.The present invention does not require the mixed mode specifically, uses mixing side well known to those skilled in the art Water-soluble solid substance is uniformly mixed by formula with sodium hyaluronate.In the present invention, the water-soluble solid substance can be right Sodium hyaluronate carries out physical dispersion, is allowed to be not easy to assemble in water to unite, to better disperse dissolution.
When the dosage of water-soluble solid substance in product formula is more than the dosage of water-soluble solid substance in solid mixture When, the present invention is carried out the water-soluble solid substance having more as remaining ingredient with liquid；When in the product formula include it is a variety of When water-soluble solid substance, the present invention can arbitrarily select one of which or several, as long as meeting above-mentioned mass ratio, remaining water Soluble solids substance is carried out as remaining ingredient with liquid.
Remaining ingredient in product formula is dissolved in the water by the present invention, obtains mixed liquor.In the present invention, the residue Component and the dosage of water are the dosage in product formula.The present invention preferably under stirring conditions carries out remaining ingredient molten Solution, the rate of the stirring is preferably 150~650r/min, more preferably 300~400r/min.
After obtaining solid mixture and mixed liquor, the present invention carries out solid mixture with mixed liquor under stirring conditions Mixing, until solid mixture is completely dissolved.In the present invention, the rate of the stirring is preferably 150~650r/min, more excellent It is selected as 300~400r/min；In the present invention, the quality of sodium hyaluronate exists less than or equal to sodium hyaluronate in the solid mixture The amount of maxima solubility in water, the quality of water-soluble solid substance is less than or equal to water-soluble solid substance in water in solid mixture The amount of middle maxima solubility.
It is described in detail below with reference to dissolving method of the embodiment to sodium hyaluronate for solution preparation provided by the invention, But they cannot be interpreted as limiting the scope of the present invention.
Embodiment 1
(1) sodium hyaluronate is uniformly mixed with natrium adetate by different quality ratio, obtains solid mixture, the two is specific Ratio and dosage be shown in Table 1；
(2) solid mixture is added in the 100mL water stirred, stirring rate 300r/min, measurement solid is mixed It closes the dissolution time of object and observes solution conditions, while with single sodium hyaluronate under same mixing speed, make dissolution speed The comparison of degree, acquired results are listed in Table 1 below.
The sodium hyaluronate and the natrium adetate dissolution time table of comparisons of 1 different proportion of table
As shown in Table 1, natrium adetate can accelerate the dissolution of sodium hyaluronate as water-soluble solid substance, molten compared to individually Sodium hyaluronate is solved, dissolution time substantially reduces, and resulting solution is clarified, and bubble is uniform, and bubbles volume is few.
Embodiment 2
(1) sodium hyaluronate is uniformly mixed with boric acid by different quality ratio, obtains solid mixture, the specific ratio of the two And dosage is shown in Table 1；
(2) solid mixture is added in the 100mL water stirred, stirring rate 650r/min, measurement solid is mixed It closes the dissolution time of object and observes solution conditions, while with single sodium hyaluronate under same mixing speed, make dissolution speed The comparison of degree, acquired results are listed in Table 2 below.
The sodium hyaluronate and the boric acid dissolution time table of comparisons of 2 different proportion of table
As shown in Table 2, boric acid can accelerate the dissolution of sodium hyaluronate as water-soluble solid substance, compared to individually dissolution glass Sour sodium, dissolution time substantially reduce, and resulting solution is clarified, and bubble is uniform, and bubbles volume is few.
Embodiment 3
(1) sodium hyaluronate is uniformly mixed with sodium chloride by different quality ratio, obtains solid mixture, the two specifically compares Example and dosage are shown in Table 1；
(2) solid mixture is added in the 100mL water stirred, stirring rate 150r/min, measurement solid is mixed It closes the dissolution time of object and observes solution conditions, while with single sodium hyaluronate under same mixing speed, make dissolution speed The comparison of degree, acquired results are listed in Table 3 below.
The sodium hyaluronate and the sodium chloride dissolution time table of comparisons of 3 different proportion of table
As shown in Table 3, sodium chloride can accelerate the dissolution of sodium hyaluronate as water-soluble solid substance, compared to individually dissolution glass Glass acid sodium, dissolution time substantially reduce, and resulting solution is clarified, and bubble is uniform, and bubbles volume is few.
Embodiment 4
Based on sodium hyaluronate in embodiment 1 and natrium adetate, by solid mixture be used for toner in liquid, The wherein formula of toner are as follows: water 92.299%, sodium hyaluronate 0.05%, butanediol 0.1%, polyethylene glycol 1%, edetic acid(EDTA) two Sodium 1.5%, propylene glycol 5%, Sodium Ascorbyl Phosphate 0.01%, methyl hydroxybenzoate 0.04%, essence 0.001%.
By toner be formulated in remaining ingredient stirring and dissolving, obtain mixed liquor；Solid mixture addition is being stirred Mixed liquor in, stirring rate 300r/min measures the dissolution time of solid mixture and observes solution conditions, gained is tied Fruit is listed in Table 4 below.
Sodium hyaluronate and natrium adetate the dissolution time table of comparisons in toner of 4 different proportion of table
As shown in Table 4, in toner during matching liquid, dissolving method provided by the invention can quickly dissolve Hyaluronic Acid Sodium, dissolution time only needs 22min, and resulting solution is clarified, and bubble is less.
Embodiment 5
Based on sodium hyaluronate in embodiment 2 and boric acid, by solid mixture be used for contact lens care solution with liquid In, the wherein formula of contact lens care solution are as follows: purified water 97.7598%, sodium hyaluronate 0.05%, boric acid 1.5%, borax 0.21%, poloxamer 0.2%, sodium chloride 0.28%, poly- amino biguanide 0.0002%.
By contact lens care solution be formulated in remaining ingredient stirring and dissolving, obtain mixed liquor；Solid mixture is added In the mixed liquor stirred, stirring rate 300r/min measures the dissolution time of solid mixture and observes solution conditions, Acquired results are listed in Table 5 below.
Sodium hyaluronate and boric acid the dissolution time table of comparisons in contact lens care solution of 5 different proportion of table
As shown in Table 5, in contact lens care solution during matching liquid, dissolving method provided by the invention can be fast instant Sodium hyaluronate is solved, dissolution time only needs 26min, and resulting solution is clarified, and bubble is less.
Embodiment 6
Based on sodium hyaluronate in embodiment 3 and sodium chloride, by obtained solid mixture be used for eye drops in liquid, The wherein formula of contact lens care solution are as follows: injection water 99%, sodium hyaluronate 0.1%, sodium chloride 0.9%.
Solid mixture is added in the injection water stirred, stirring rate 300r/min, measures solid mixture Dissolution time and observe solution conditions, acquired results are listed in Table 6 below.
Sodium hyaluronate and sodium chloride the dissolution time table of comparisons in eye drops of 6 different proportion of table
As shown in Table 6, in eye drops during matching liquid, dissolving method provided by the invention can quickly dissolve Hyaluronic Acid Sodium, dissolution time only needs 20min, and resulting solution is clarified, and bubble is less.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered It is considered as protection scope of the present invention.

Claims (5)

1. a kind of dissolving method of sodium hyaluronate for solution preparation, comprising the following steps:
(1) the water-soluble solid substance in product formula is mixed with sodium hyaluronate, obtains solid mixture；The product be with It include the liquid form product of water-soluble solid substance and sodium hyaluronate in side；
(2) remaining ingredient in product formula is dissolved in the water, obtains mixed liquor；
(3) solid mixture is mixed under stirring conditions with mixed liquor, until solid mixture is completely dissolved；
The limitation of the not no time sequencing in the step (1) and (2).
2. dissolving method according to claim 1, which is characterized in that product in the step (1) be cosmetic emulsion, Toner, contact lens care solution or eye drops.
3. dissolving method according to claim 1, which is characterized in that water-soluble solid substance is water in the step (1) Soluble and/or water-soluble solid acid, the water soluble salt be chlorate, phosphate, sulfate, borate, citrate and One or more of edetate, the water-soluble solid acid are one or more of boric acid, citric acid and tartaric acid.
4. dissolving method according to claim 1, which is characterized in that sodium hyaluronate and water solubility are solid in the step (1) The mass ratio of body substance is 1:1~50.
5. the method according to claim 1, wherein the rate stirred in the step (3) is 150~650r/ min。
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1183302A (en) * 1996-11-22 1998-06-03 凌沛学 Eye drops contg. sodium hyaluronate and preparing method thereof
CN102697713A (en) * 2012-06-14 2012-10-03 浙江尖峰药业有限公司 Sodium hyaluronate eye drops and a preparation method thereof
CN103816543A (en) * 2013-12-10 2014-05-28 上海景峰制药股份有限公司 Preparation method for phosphate buffer solution

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Publication number Priority date Publication date Assignee Title
CN1183302A (en) * 1996-11-22 1998-06-03 凌沛学 Eye drops contg. sodium hyaluronate and preparing method thereof
CN102697713A (en) * 2012-06-14 2012-10-03 浙江尖峰药业有限公司 Sodium hyaluronate eye drops and a preparation method thereof
CN103816543A (en) * 2013-12-10 2014-05-28 上海景峰制药股份有限公司 Preparation method for phosphate buffer solution

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