CN109453086A - A kind of plant compound bacteriostatic hand sanitizer and preparation method thereof - Google Patents
A kind of plant compound bacteriostatic hand sanitizer and preparation method thereof Download PDFInfo
- Publication number
- CN109453086A CN109453086A CN201811606300.9A CN201811606300A CN109453086A CN 109453086 A CN109453086 A CN 109453086A CN 201811606300 A CN201811606300 A CN 201811606300A CN 109453086 A CN109453086 A CN 109453086A
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- plant compound
- oil
- hand sanitizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of plant compound bacteriostatic hand sanitizers and preparation method thereof.Contain plant compound bacteria inhibiting composition in the plant compound bacteriostatic hand sanitizer, the plant compound bacteria inhibiting composition is made of Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, Radix Flemingiae Philippinensis extract, cherokee rose root extract and angelica extract.The present invention has reached significant cooperative synergism effect, has had stronger bacteriostasis by compounding various plants extract according to a certain percentage.By plant compound bacteria inhibiting composition and other auxiliary materials compound by a certain percentage made of plant compound bacteriostatic hand sanitizer, cleaning dirt-removing power is strong, non-stimulated to skin, easy to foaming, Yi Chongxi when use, salubrious comfortable after washing.The plant component of use effectively prevents the erosion and harm of chemical component, brings convenient, safely effectively bactericidal effect, practical value with higher and good application prospect for personal cleanliness's nursing.
Description
Technical field
The present invention relates to daily chemical products technical fields, and in particular, to a kind of plant compound bacteriostatic hand sanitizer and its preparation
Method.
Background technique
In recent years, as people's living standard increasingly improves and the reinforcement of health consciousness, people increasingly pay attention to hand
Health problem.It washes one's hands and is related to our health, washing one's hands is thing that everyone will do daily, and frequently washing one's hands is to maintain
The good habit of people's health even more prevents the important intervening measure of transmission.According to health and epidemic prevention department's introduction, blood-shoot-eye illness, skin
Skin disease, hepatitis A, bacillary dysentery etc. are typically all to be infected by the contact of hand.The infections sources such as bacterium and virus are one
A little public places and using being easiest to propagate in frequent article, these places be all infectious disease cross-infection high-incidencely.If
People will contact these things daily, and think little of the health of hand, then the probability being infected will be very high.Cause
This, simple decontamination is also not only satisfied in requirement of the people for wash product, it is also desirable to can reach certain antibacterial anti-
Bacterium effect.
Existing wash product on the market is many kinds of, such as soap, perfumed soap, hand cleanser, condensation of washing one's hands, disposable hand cleanser
Deng.Wherein, hand cleanser is environment friendly and pollution-free with its, mild non-stimulated, easy to use, hard water resistance, easy cleaning, easily stored, foam
The advantages that enriching and washing rear skin lubrication sense, is increasingly becoming the substitute of traditional hand-washing article, wide in family and public place
General application.
Hand cleanser available on the market is although various, but many products is more or less added to some be harmful to the human body
Substance: such as bleaching powder, mercury, detergent, corrosive agent, long-time service have corrosiveness to the skin of people.Accordingly it is desirable to energy
Develop the hand cleanser that fungistatic effect is more preferable and does not hurt hands.Plant component contains natural bacteriostatic substance, mild and harmless, because
This prepares feasible a kind of selection that hand cleanser is row using plant component.It is washed therefore, it is necessary to invent a kind of plant compound
Hand liquid reduces the generation of health event.To sum up, be now badly in need of studying a cleaning effect is good, good antimicrobial effect, have no toxic side effect,
Mild inirritative hand cleanser.
Summary of the invention
The purpose of the invention is to overcome the above-mentioned deficiency of the prior art, a kind of plant compound bacteria inhibiting composition is provided,
By preferably compounding the ratio of each plant component, significant synergy is reached, can be effectively antibacterial and stimulated mildly.
Another object of the present invention is to provide above-mentioned plant compound bacteria inhibiting compositions in preparing antibacterial daily chemical products
Using.
Another object of the present invention is to provide a kind of plant compound bacteriostatic hand sanitizers.
Another object of the present invention is to provide the preparation methods of above-mentioned plant compound bacteriostatic hand sanitizer.
To achieve the goals above, the present invention is achieved by following scheme:
A kind of plant compound bacteria inhibiting composition, by Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, philippine flemingia root
Extract, cherokee rose root extract and angelica extract composition.
Saponaria officinalis is pinkwort.Saponaretin rich in Saponaria officinalis extract.Wherein, saponaretin contains
Many ribosome inactivating proteins (RIPs), RIPs have special N- glycosidase activity, can selectively acting in eukaryocyte core
Sugared body and the exposed rRNA of prokaryotic cell make its depurination, thus the effect of inhibiting protein to synthesize, reaching antibacterial.It is used for
In the present invention, fungistatic effect can be improved.
Fructus Citri grandis extract is primarily present in the fruit of Citrus paradisi Macfadyen, and functional components shaddock is contained in Fructus Citri grandis extract
Skin glycosides, aurantiin have antibacterial anti-inflammatory, antiviral, the anti-mutation of anticancer, antiallergy, antiulcer, analgesia, hypotensive activity, can drop
Low cholesterol, the formation for reducing thrombus improve local microcirculation and nutrition supply, can be used for producing prevention and treatment cardiovascular and cerebrovascular disease.
Herba Andrographitis is acanthaceous plant, the herb or leaf of Herba Andrographitis, bitter, cold in nature, have clearing heat and detoxicating, swelling and pain relieving,
Antibacterial and antitumaous effect are usually used in treating acute bacillary dysentery, abscess of throat, sore carbuncle serious case of furuncle, trauma infection contamination etc..
Philippine flemingia root also known as colour of loess chicken, golden pheasant landing, property acrid-sweet flavor, temperature have expelling wind and removing dampness, and the function of dispersing blood stasis removing toxic substances can
Control rheumatic arthralgia, chronic nephritis, traumatic injury, carbuncle swells, tonsillitis.
Cherokee rose root also known as Jin Ying Jiang, de- bone are red, and cherokee rose root has the function of reinforcing the kidney and controlling nocturnal emission, cures mainly spermatorrhoea, the enuresis, dysentery and lets out
The diseases such as rush down, scald.Cherokee rose root water extract has one to staphylococcus aureus, Pseudomonas aeruginosa, proteus, typhoid bacillus etc.
Fixed fungistatic effect.
Radix Angelicae Sinensis, it is sweet, pungent, warm, return liver, the heart, the spleen channel, major function: replenishing and activating blood, menstruction regulating and pain relieving, relax bowel and defecation.For blood
Empty sallow, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores and intestinal dryness are just
It is secret.
Plant compound bacteria inhibiting composition provided by the present invention is mentioned using Saponaria officinalis extract, Fructus Citri grandis extract, Herba Andrographitis
The natural plant active components such as object, Radix Flemingiae Philippinensis extract, cherokee rose root extract and angelica extract are taken, bacteriostasis antibiosis function is all had
Effect, by each plant component compatible use, proportion dosage preferably between each component can be effectively antibacterial, such as to common Escherichia coli,
The pathogens such as staphylococcus aureus, Candida albicans have obvious inhibiting effect；And it is not added with any chemical component, mildly
It does not stimulate.
Preferably, Saponaria officinalis extract in the plant compound bacteria inhibiting composition, Fructus Citri grandis extract, Andrographis Paniculata,
The weight ratio of Radix Flemingiae Philippinensis extract, cherokee rose root extract and angelica extract is (1~5): (1~5): (1~5): (1~5): (1
~5).
It is highly preferred that Saponaria officinalis extract, Fructus Citri grandis extract, Herba Andrographitis extract in the plant compound bacteria inhibiting composition
Object, Radix Flemingiae Philippinensis extract, cherokee rose root extract and angelica extract weight ratio be 1:1:1:1:1:1.
The present invention is also claimed the plant compound bacteria inhibiting composition and is preparing the application in antibacterial daily chemical products.
Preferably, the antibacterial daily chemical products are bacteriostatic hand sanitizer, bacterium-suppressing shower lotion or bacteriostatic lotion.
A kind of plant compound bacteriostatic hand sanitizer containing above-mentioned plant compound bacteria inhibiting composition is also claimed in the present invention.
The plant compound bacteriostatic hand sanitizer is grouped as by each group of following parts by weight: 60~70 parts of deionized water, the moon
8~12 parts of laureth sodium sulfovinate, 1.5~2.0 parts of sodium lauroyl sarcosine, 0.1~0.5 part of lauroyl arginine ethyl ester,
Cocoyl -5~15 parts of glucoside tartrate sodium, 3~6 parts of Cocoamidopropyl betaine, lauroyl glutamate TEA salt 2~7
Part, 0.1~0.5 part of Sensiva SC50,0.01~0.05 part of camellia seed oil, 0.01~0.05 part of peony seed oil, oil and fat of sacha inchi
0.01~0.05 part, 0.01~0.03 part of oil/water of PPG-26 butylol polyether -26/PEG-40 hydrogenated castor, Saponaria officinalis extract
0.01~0.05 part, 0.01~0.05 part of Fructus Citri grandis extract, 0.01~0.05 part of Andrographis Paniculata, Radix Flemingiae Philippinensis extract 0.01
~0.05 part, 0.01~0.05 part of cherokee rose root extract, 0.01~0.05 part of angelica extract, DMDMH0.1~0.2 part, sorb
0.2~0.6 part of sour potassium, 0.02~0.03 part of tea tree ethereal oil, 0.02~0.03 part of grapefruit essential oil, Bergamot 0.001~
0.01 part, 0.4~0.8 part of essence, 0.5~1.0 part of citric acid.
Saponaria officinalis extract mentioned in the present invention, Fructus Citri grandis extract, Andrographis Paniculata, Radix Flemingiae Philippinensis extract, Jin Ying
Root extract, angelica extract, camellia seed oil, peony seed oil, oil and fat of sacha inchi, tea tree ethereal oil, grapefruit essential oil and bergamot essence
Oil can be directly commercially available, or utilize marketable material, extracted and obtained referring to extracting method in the prior art.It obtains
Extract and essential oil can by further by column chromatography or high performance liquid chromatography etc. in a manner of be further purified.
Preferably, the plant compound bacteriostatic hand sanitizer is grouped as by each group of following parts by weight: deionized water 62~
67 parts, 8~10 parts of laureth sodium sulfovinate, 1.6~1.9 parts of sodium lauroyl sarcosine, lauroyl arginine ethyl ester 0.1~
0.3 part, cocoyl -5~10 parts of glucoside tartrate sodium, 3~5 parts of Cocoamidopropyl betaine, lauroyl glutamate TEA
2~6 parts of salt, 0.2~0.5 part of Sensiva SC50,0.01~0.05 part of camellia seed oil, 0.01~0.05 part of peony seed oil, beauty
0.01~0.05 part of rattan fruit oil, 0.01~0.02 part of oil/water of PPG-26 butylol polyether -26/PEG-40 hydrogenated castor, Saponaria officinalis mentions
Take 0.01~0.05 part of object, 0.01~0.05 part of Fructus Citri grandis extract, 0.01~0.05 part of Andrographis Paniculata, Radix Flemingiae Philippinensis extract
0.01~0.05 part, 0.01~0.05 part of cherokee rose root extract, 0.01~0.05 part of angelica extract, DMDMH 0.13~0.18
Part, 0.2~0.5 part of potassium sorbate, 0.02~0.03 part of tea tree ethereal oil, 0.02~0.03 part of grapefruit essential oil, Bergamot
0.001~0.01 part, 0.4~0.6 part of essence, 0.6~0.9 part of citric acid.
It is highly preferred that the plant compound bacteriostatic hand sanitizer is grouped as by each group of following parts by weight: deionized water 64
Part, 9 parts of laureth sodium sulfovinate, 1.8 parts of sodium lauroyl sarcosine, 0.2 part of lauroyl arginine ethyl ester, cocoyl-Portugal
9 parts of glucosides tartrate sodium, 4 parts of Cocoamidopropyl betaine, 4.5 parts of lauroyl glutamate TEA salt, Sensiva SC50
0.4 part, 0.01 part of camellia seed oil, 0.01 part of peony seed oil, 0.01 part of oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 hydrogen
0.015 part of castor-oil plant oil/water of change, 0.01 part of Saponaria officinalis extract, 0.01 part of Fructus Citri grandis extract, 0.01 part of Andrographis Paniculata, thousand
Jin pulls out 0.01 part of extract, and 0.01 part of cherokee rose root extract, 0.01 part of angelica extract, 0.15 part of DMDMH, potassium sorbate 0.3
Part, 0.025 part of tea tree ethereal oil, 0.025 part of grapefruit essential oil, 0.005 part of Bergamot, 0.5 part of essence, 0.8 part of citric acid.
Further, the preparation method of the plant compound bacteriostatic hand sanitizer, includes the following steps:
S1. by deionized water, laureth sodium sulfovinate, sodium lauroyl sarcosine and lauroyl arginine ethyl ester press than
Example is uniformly mixed, and 10~15min is stirred under the conditions of 50~55 DEG C to being completely dissolved, obtains mixture A；
S2. object A to be mixed is cooled to 40~45 DEG C, and cocoyl-glucoside winestone is successively added into mixture A in proportion
Acid esters sodium, Cocoamidopropyl betaine, lauroyl glutamate TEA salt and Sensiva SC50 stir 10~15min, obtain mixed
Close object B；
S3. first by camellia seed oil, peony seed oil, oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
Water mixes in proportion, and obtains mixture C；Mixture C is added in mixture B again, 10~15min of stirring is saturating to Material clarification
It is bright, obtain mixture D；
S4. Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, very heavy is successively added into mixture D in proportion
Pull out extract, cherokee rose root extract, angelica extract, DMDMH, potassium sorbate, tea tree ethereal oil, grapefruit essential oil, bergamot essence
Oil and essence, stir evenly；Citric acid is slowly repeatedly added again, after mixing evenly up to plant compound bacteriostatic hand sanitizer.
Preferably, whipping temp described in step S1 is 50 DEG C, mixing time 10min.
Preferably, after object A to be mixed is cooled to 40 DEG C in step S2, then cocounut oil successively is added into mixture A in proportion
Base-glucoside tartrate sodium, Cocoamidopropyl betaine, lauroyl glutamate TEA salt and Sensiva SC50, stirring
10min obtains mixture B.
Preferably, mixing time is 10min in step S3.
Compared with prior art, the invention has the following advantages:
1, plant compound bacteria inhibiting composition provided by the present invention by preferably compounding a variety of natural plants according to a certain percentage
Object extract has reached significant cooperative synergism effect, has stronger bacteriostasis, to common Escherichia coli, golden yellow grape
The pathogens such as coccus, Candida albicans have obvious inhibiting effect, can effectively inhibit disease common in human skin or environment
Fungal pathogens or bacterium, the effective guarantee hygiene and health of people.
2, the present invention by plant compound bacteria inhibiting composition and other auxiliary materials (such as plants essential oil, surfactant, moisturizer,
Emulsifier, preservative, pH adjusting agent etc.) manufactured plant compound bacteriostatic hand sanitizer is preferably compounded by a certain percentage, clean decontamination
Ability is strong, non-stimulated to skin, easy to foaming, Yi Chongxi when use, salubrious comfortable after washing, while can also reach bacteriostasis antibiosis function
Effect.
3, plant compound bacteriostatic hand sanitizer provided by the invention uses natural plant composition, effectively prevents chemical component
Erosion and harm, bring that convenient, safely effectively bactericidal effect, used raw material are easy to get for personal cleanliness's nursing,
Preparation method is easy, environmentally protective, is suitble to large-scale production, practical value with higher and good application prospect.
Specific embodiment
The present invention is made combined with specific embodiments below and further being elaborated, the embodiment is served only for explaining this
Invention, is not intended to limit the scope of the present invention.Test method as used in the following examples is normal unless otherwise specified
Rule method；Used material, reagent etc., unless otherwise specified, for the reagent and material commercially obtained.
The camellia seed oil is camellia (CAMELLIA JAPONICA) seed oil；
The peony seed oil is tree peony (PAEONIA SUFFRUTICOSA) seed oil；
The oil and fat of sacha inchi is print plus fruit (PLUKENETIA VOLUBILIS) seed oil；
The Saponaria officinalis extract is Saponaria officinalis (SAPONARIA OFFICINALIS) extract；
The Fructus Citri grandis extract is shaddock (CITRUS GRANDIS) berry extract；
The Andrographis Paniculata is Herba Andrographitis (ANDROGRAPHIS PANICULATA) extract；
The tea tree ethereal oil is Melaleuca alternifolia (MELALEUCA ALTERNIFOLIA) leaf oil；
The grapefruit essential oil is grape fruit (CITRUS PARADISI) peel oil；
The Bergamot is bergamot (CITRUS A URANTIUM BERGAMIA) fruit oil.
A kind of plant compound bacteriostatic hand sanitizer of embodiment 1 and preparation method thereof
(1) it is formulated
A kind of plant compound bacteriostatic hand sanitizer, is grouped as by each group of following parts by weight: 64 parts of deionized water, laruyl alcohol
9 parts of polyethers sodium sulfovinate, 1.8 parts of sodium lauroyl sarcosine, 0.2 part of lauroyl arginine ethyl ester, cocoyl-glucoside tartaric acid
9 parts of ester sodium, 4 parts of Cocoamidopropyl betaine, 4.5 parts of lauroyl glutamate TEA salt, 0.4 part of Sensiva SC50, camellia seed
0.01 part of oil, 0.01 part of peony seed oil, 0.01 part of oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 hydrogenated castor oil/water
0.015 part, 0.01 part of Saponaria officinalis extract, 0.01 part of Fructus Citri grandis extract, 0.01 part of Andrographis Paniculata, Radix Flemingiae Philippinensis extract
0.01 part, 0.01 part of cherokee rose root extract, 0.01 part of angelica extract, 0.15 part of DMDMH, 0.3 part of potassium sorbate, tea tree essence
0.025 part, 0.025 part of grapefruit essential oil, 0.005 part of Bergamot, 0.5 part of essence, 0.8 part of citric acid of oil.
(2) preparation method
S1. by deionized water, laureth sodium sulfovinate, sodium lauroyl sarcosine and lauroyl arginine ethyl ester press than
Example is uniformly mixed, and 10min is stirred under the conditions of 50 DEG C to being completely dissolved, obtains mixture A；
S2. object A to be mixed is cooled to 40 DEG C, and cocoyl-glucoside tartrate is successively added into mixture A in proportion
Sodium, Cocoamidopropyl betaine, lauroyl glutamate TEA salt and Sensiva SC50 stir 10min, obtain mixture B；
S3. first by camellia seed oil, peony seed oil, oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
Water mixes in proportion, and obtains mixture C；Mixture C is added in mixture B again, stirring 10min to Material clear,
Obtain mixture D；
S4. Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, very heavy is successively added into mixture D in proportion
Pull out extract, cherokee rose root extract, angelica extract, DMDMH, potassium sorbate, tea tree ethereal oil, grapefruit essential oil, bergamot essence
Oil and essence, stir evenly；Citric acid is slowly repeatedly added again, after mixing evenly up to plant compound bacteriostatic hand sanitizer.
A kind of plant compound bacteriostatic hand sanitizer of embodiment 2 and preparation method thereof
(1) it is formulated
A kind of plant compound bacteriostatic hand sanitizer, is grouped as by each group of following parts by weight: 60 parts of deionized water, laruyl alcohol
8 parts of polyethers sodium sulfovinate, 1.5 parts of sodium lauroyl sarcosine, 0.1 part of lauroyl arginine ethyl ester, cocoyl-glucoside tartaric acid
5 parts of ester sodium, 3 parts of Cocoamidopropyl betaine, 2 parts of lauroyl glutamate TEA salt, 0.25 part of Sensiva SC50, camellia seed
0.025 part of oil, 0.025 part of peony seed oil, 0.025 part of oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
0.02 part of water, 0.025 part of Saponaria officinalis extract, 0.025 part of Fructus Citri grandis extract, 0.025 part of Andrographis Paniculata, philippine flemingia root is extracted
0.025 part of object, 0.025 part of cherokee rose root extract, 0.025 part of angelica extract, 0.15 part of DMDMH, 0.4 part of potassium sorbate, tea
0.025 part of essential oil, 0.025 part of grapefruit essential oil, 0.005 part of Bergamot, 0.6 part of essence, 0.75 part of citric acid of tree.
(2) preparation method
S1. by deionized water, laureth sodium sulfovinate, sodium lauroyl sarcosine and lauroyl arginine ethyl ester press than
Example is uniformly mixed, and 10min is stirred under the conditions of 50 DEG C to being completely dissolved, obtains mixture A；
S2. object A to be mixed is cooled to 40 DEG C, and cocoyl-glucoside tartrate is successively added into mixture A in proportion
Sodium, Cocoamidopropyl betaine, lauroyl glutamate TEA salt and Sensiva SC50 stir 10min, obtain mixture B；
S3. first by camellia seed oil, peony seed oil, oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
Water mixes in proportion, and obtains mixture C；Mixture C is added in mixture B again, stirring 10min to Material clear,
Obtain mixture D；
S4. Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, very heavy is successively added into mixture D in proportion
Pull out extract, cherokee rose root extract, angelica extract, DMDMH, potassium sorbate, tea tree ethereal oil, grapefruit essential oil, bergamot essence
Oil and essence, stir evenly；Citric acid is slowly repeatedly added again, after mixing evenly up to plant compound bacteriostatic hand sanitizer.
A kind of plant compound bacteriostatic hand sanitizer of embodiment 3 and preparation method thereof
(1) it is formulated
A kind of plant compound bacteriostatic hand sanitizer, is grouped as by each group of following parts by weight: 70 parts of deionized water, laruyl alcohol
12 parts of polyethers sodium sulfovinate, 2.0 parts of sodium lauroyl sarcosine, 0.5 part of lauroyl arginine ethyl ester, cocoyl-glucoside winestone
15 parts of acid esters sodium, 6 parts of Cocoamidopropyl betaine, 7 parts of lauroyl glutamate TEA salt, 0.5 part of Sensiva SC50, camellia
0.05 part of seed oil, 0.05 part of peony seed oil, 0.05 part of oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
0.003 part of water, 0.05 part of Saponaria officinalis extract, 0.05 part of Fructus Citri grandis extract, 0.05 part of Andrographis Paniculata, Radix Flemingiae Philippinensis extract
0.05 part, 0.05 part of cherokee rose root extract, 0.05 part of angelica extract, DMDMH0.2 parts, 0.6 part of potassium sorbate, tea tree ethereal oil
0.03 part, 0.03 part of grapefruit essential oil, 0.01 part of Bergamot, 0.8 part of essence, 1.0 parts of citric acid.
(2) preparation method
S1. by deionized water, laureth sodium sulfovinate, sodium lauroyl sarcosine and lauroyl arginine ethyl ester press than
Example is uniformly mixed, and 10min is stirred under the conditions of 50 DEG C to being completely dissolved, obtains mixture A；
S2. object A to be mixed is cooled to 40 DEG C, and cocoyl-glucoside tartrate is successively added into mixture A in proportion
Sodium, Cocoamidopropyl betaine, lauroyl glutamate TEA salt and Sensiva SC50 stir 10min, obtain mixture B；
S3. first by camellia seed oil, peony seed oil, oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
Water mixes in proportion, and obtains mixture C；Mixture C is added in mixture B again, stirring 10min to Material clear,
Obtain mixture D；
S4. Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, very heavy is successively added into mixture D in proportion
Pull out extract, cherokee rose root extract, angelica extract, DMDMH, potassium sorbate, tea tree ethereal oil, grapefruit essential oil, bergamot essence
Oil and essence, stir evenly；Citric acid is slowly repeatedly added again, after mixing evenly up to plant compound bacteriostatic hand sanitizer.
A kind of plant compound bacteriostatic hand sanitizer of embodiment 4 and preparation method thereof
(1) it is formulated
A kind of plant compound bacteriostatic hand sanitizer, is grouped as by each group of following parts by weight: 65 parts of deionized water, laruyl alcohol
9 parts of polyethers sodium sulfovinate, 1.8 parts of sodium lauroyl sarcosine, 0.4 part of lauroyl arginine ethyl ester, cocoyl-glucoside tartaric acid
12 parts of ester sodium, 4 parts of Cocoamidopropyl betaine, 6 parts of lauroyl glutamate TEA salt, 0.3 part of Sensiva SC50, camellia seed
0.03 part of oil, 0.04 part of peony seed oil, 0.03 part of oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 hydrogenated castor oil/water
0.02 part, 0.03 part of Saponaria officinalis extract, 0.03 part of Fructus Citri grandis extract, 0.04 part of Andrographis Paniculata, Radix Flemingiae Philippinensis extract
0.03 part, 0.03 part of cherokee rose root extract, 0.03 part of angelica extract, 0.15 part of DMDMH, 0.5 part of potassium sorbate, tea tree essence
0.022 part, 0.024 part of grapefruit essential oil, 0.006 part of Bergamot, 0.5 part of essence, 0.6 part of citric acid of oil.
(2) preparation method
S1. by deionized water, laureth sodium sulfovinate, sodium lauroyl sarcosine and lauroyl arginine ethyl ester press than
Example is uniformly mixed, and 10min is stirred under the conditions of 50 DEG C to being completely dissolved, obtains mixture A；
S2. object A to be mixed is cooled to 40 DEG C, and cocoyl-glucoside tartrate is successively added into mixture A in proportion
Sodium, Cocoamidopropyl betaine, lauroyl glutamate TEA salt and Sensiva SC50 stir 10min, obtain mixture B；
S3. first by camellia seed oil, peony seed oil, oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
Water mixes in proportion, and obtains mixture C；Mixture C is added in mixture B again, stirring 10min to Material clear,
Obtain mixture D；
S4. Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, very heavy is successively added into mixture D in proportion
Pull out extract, cherokee rose root extract, angelica extract, DMDMH, potassium sorbate, tea tree ethereal oil, grapefruit essential oil, bergamot essence
Oil and essence, stir evenly；Citric acid is slowly repeatedly added again, after mixing evenly up to plant compound bacteriostatic hand sanitizer.
A kind of plant compound bacteriostatic hand sanitizer of embodiment 5 and preparation method thereof
(1) it is formulated
A kind of plant compound bacteriostatic hand sanitizer, is grouped as by each group of following parts by weight: 63 parts of deionized water, laruyl alcohol
11 parts of polyethers sodium sulfovinate, 1.9 parts of sodium lauroyl sarcosine, 0.4 part of lauroyl arginine ethyl ester, cocoyl-glucoside winestone
14 parts of acid esters sodium, 4 parts of Cocoamidopropyl betaine, 4 parts of lauroyl glutamate TEA salt, 0.2 part of Sensiva SC50, camellia
0.03 part of seed oil, 0.03 part of peony seed oil, 0.03 part of oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
0.015 part of water, 0.02 part of Saponaria officinalis extract, 0.01 part of Fructus Citri grandis extract, 0.05 part of Andrographis Paniculata, Radix Flemingiae Philippinensis extract
0.02 part, 0.04 part of cherokee rose root extract, 0.01 part of angelica extract, DMDMH0.12 parts, 0.5 part of potassium sorbate, tea tree ethereal oil
0.02 part, 0.03 part of grapefruit essential oil, 0.005 part of Bergamot, 0.5 part of essence, 0.5 part of citric acid.
(2) preparation method
S1. by deionized water, laureth sodium sulfovinate, sodium lauroyl sarcosine and lauroyl arginine ethyl ester press than
Example is uniformly mixed, and 10min is stirred under the conditions of 50 DEG C to being completely dissolved, obtains mixture A；
S2. object A to be mixed is cooled to 40 DEG C, and cocoyl-glucoside tartrate is successively added into mixture A in proportion
Sodium, Cocoamidopropyl betaine, lauroyl glutamate TEA salt and Sensiva SC50 stir 10min, obtain mixture B；
S3. first by camellia seed oil, peony seed oil, oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
Water mixes in proportion, and obtains mixture C；Mixture C is added in mixture B again, stirring 10min to Material clear,
Obtain mixture D；
S4. Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, very heavy is successively added into mixture D in proportion
Pull out extract, cherokee rose root extract, angelica extract, DMDMH, potassium sorbate, tea tree ethereal oil, grapefruit essential oil, bergamot essence
Oil and essence, stir evenly；Citric acid is slowly repeatedly added again, after mixing evenly up to plant compound bacteriostatic hand sanitizer.
A kind of plant compound bacteriostatic hand sanitizer of embodiment 6 and preparation method thereof
(1) it is formulated
A kind of plant compound bacteriostatic hand sanitizer, is grouped as by each group of following parts by weight: 64 parts of deionized water, laruyl alcohol
9 parts of polyethers sodium sulfovinate, 1.8 parts of sodium lauroyl sarcosine, 0.2 part of lauroyl arginine ethyl ester, cocoyl-glucoside tartaric acid
9 parts of ester sodium, 4 parts of Cocoamidopropyl betaine, 4.5 parts of lauroyl glutamate TEA salt, 0.4 part of Sensiva SC50, camellia
0.01 part of seed oil, 0.01 part of peony seed oil, 0.01 part of oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
0.015 part of water, 0.02 part of Saponaria officinalis extract, 0.02 part of Fructus Citri grandis extract, 0.04 part of Andrographis Paniculata, Radix Flemingiae Philippinensis extract
0.03 part, 0.03 part of cherokee rose root extract, 0.02 part of angelica extract, 0.15 part of DMDMH, 0.4 part of potassium sorbate, tea tree essence
0.025 part, 0.025 part of grapefruit essential oil, 0.005 part of Bergamot, 0.5 part of essence, 0.8 part of citric acid of oil.
(2) preparation method
S1. by deionized water, laureth sodium sulfovinate, sodium lauroyl sarcosine and lauroyl arginine ethyl ester press than
Example is uniformly mixed, and 10min is stirred under the conditions of 50 DEG C to being completely dissolved, obtains mixture A；
S2. object A to be mixed is cooled to 40 DEG C, and cocoyl-glucoside tartrate is successively added into mixture A in proportion
Sodium, Cocoamidopropyl betaine, lauroyl glutamate TEA salt and Sensiva SC50 stir 10min, obtain mixture B；
S3. first by camellia seed oil, peony seed oil, oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 rilanit special/
Water mixes in proportion, and obtains mixture C；Mixture C is added in mixture B again, stirring 10min to Material clear,
Obtain mixture D；
S4. Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, very heavy is successively added into mixture D in proportion
Pull out extract, cherokee rose root extract, angelica extract, DMDMH, potassium sorbate, tea tree ethereal oil, grapefruit essential oil, bergamot essence
Oil and essence, stir evenly；Citric acid is slowly repeatedly added again, after mixing evenly up to plant compound bacteriostatic hand sanitizer.
A kind of hand cleanser of comparative example 1~6
For comparative example 1 in addition to not containing Saponaria officinalis extract in hand sanitizer formula, remaining component is same as Example 1；
For comparative example 2 in addition to not containing Fructus Citri grandis extract in hand sanitizer formula, remaining component is same as Example 1；
For comparative example 3 in addition to not containing Andrographis Paniculata in hand sanitizer formula, remaining component is same as Example 1；
For comparative example 4 in addition to not containing Radix Flemingiae Philippinensis extract in hand sanitizer formula, remaining component is same as Example 1；
For comparative example 5 in addition to not containing cherokee rose root extract in hand sanitizer formula, remaining component is same as Example 1；
For comparative example 6 in addition to not containing angelica extract in hand sanitizer formula, remaining component is same as Example 1.
The preparation method of comparative example 1~6 is same as Example 1.
1 quality evaluation of application examples
It is antibacterial to Examples 1 to 6 plant compound to wash one's hands referring to the standard GB/T 19877.1-2005 of extraordinary hand cleanser
It is as follows that liquid carries out sense organ, stability, physicochemical property and microbiological indicator measurement, measurement result.
1, sense organ
Appearance: Examples 1 to 6 plant compound bacteriostatic hand sanitizer is not stratified, transparent, no suspended substance or precipitating, without obvious
Mechanical admixture is met the requirements of the standard.
Smell: the equal free from extraneous odour of Examples 1 to 6 plant compound bacteriostatic hand sanitizer meets regulation odor type.
2, stability
Cold-resistant situation: it places in -5 DEG C ± 2 DEG C of refrigerator for 24 hours, is observed when taking out recovery to room temperature, Examples 1 to 6 is planted
Object compound bacteriostatic hand sanitizer is haze-free without precipitating and without metachromatism, meets the requirements of the standard.
Heat-resisting situation: it places in 40 DEG C ± 1 DEG C of refrigerator for 24 hours, is observed when taking out recovery to room temperature, Examples 1 to 6 is planted
The equal free from extraneous odour of object compound bacteriostatic hand sanitizer, without layering and without metachromatism, it is haze-free, meet the requirements of the standard.
3, physicochemical property and microbiological indicator measurement
The physicochemical property and microbiological indicator measurement result of Examples 1 to 6 plant compound bacteriostatic hand sanitizer are as shown in table 1.
The physicochemical property and microbioassay result of 1 Examples 1 to 6 plant compound bacteriostatic hand sanitizer of table
More than 2 intact skin irritant tests of application examples
Referring to " disinfection technology standard " 2002 editions, repeatedly complete skin is carried out to Examples 1 to 6 plant compound bacteriostatic hand sanitizer
Skin irritant test.
1, operating procedure
(1) before the test for 24 hours, the hair of rabbit or guinea pig back backbone two sides is removed with depilatory agent or scissors, must not be damaged
Hurt skin.Unhairing range, left and right each about 3cm × 3cm.
(2) tested material (concentration be generally skin degerming application liquid 5 times or stoste 0.5mL (g)) is coated in side by next day
On skin, the other side applies solvent as control, and the 4h after smearing is cleaned with water or non-stimulated suitable solvent, removes residue.
It smears once daily, continuously smears 14d.Observation for 24 hours by table 2 as a result, score after each smear.For the ease of the painting of tested material
It smears and is observed with result, answer cropping when necessary.The same trial zone of the processing method of check plot.
2, evaluation regulation
Daily every animal average integral (stimulus index) is calculated according to the following formula, and skin irritatin intensity is determined with table 3.
The results are shown in Table 4 to rabbit skin irritation test for Examples 1 to 6 plant compound bacteriostatic hand sanitizer.
The standards of grading of 2 skin wound repair of table
3 skin irritatin strength grading of table
4 Examples 1 to 6 plant compound bacteriostatic hand sanitizer of table is to rabbit skin irritation test result
As seen from the results in Table 4, Examples 1 to 6 plant compound bacteriostatic hand sanitizer is 0 to the scoring of rabbit skin wound repair,
Belong to non-stimulated rank, it is mild to skin, it is highly-safe.
3 bacteriostatic test of application examples
Referring to " sterile products Hygienic safety evaluation technical requirements " WS 628-2018 and disinfection technology standard (2002 years
Version), extracorporeal bacteria inhibitor test is carried out to Examples 1 to 6 plant compound bacteriostatic hand sanitizer and 1~6 hand cleanser of comparative example.
1, material and bacteria suspension preparation
(1) test strain
Staphylococcus aureus (ATCC6538), Escherichia coli (8099 or ATCC 11229), Candida albicans
(ATCC10231)。
(2) preparation of bacteria suspension
Strain tube is opened in a manner of sterile working, and adequate nutrition broth bouillon, soft pressure-vaccum number is added with capillary syring
It is secondary, so that strain is melted dispersion.The test tube containing 5.0mL~10.0mL nutrient broth medium is taken, a little bacteria suspension is instilled, sets 37 DEG C
Culture 18h~for 24 hours.The bacteria suspension of 1st generation culture is taken with oese, streak inoculation sets 37 on nutrient agar plate
DEG C culture 18h~for 24 hours.Or be inoculated on plate from a bacterium pearl is taken out in microbank, 37 DEG C of culture 18h~for 24 hours are set, are chosen
Colonies typical in above-mentioned 2nd generation culture is taken, nutrient agar slopes are inoculated in, sets 37 DEG C of culture 18h~for 24 hours, the as the 3rd is commissioned to train
Support object.Repeat several generations.The fresh slant culture for taking the nutrient agar culture 18h in the 3rd~6 generation~for 24 hours, uses 5.0mL
Suction pipe is drawn 3.0mL~5.0mL dilution (generally using TPS, acidifying water physiological saline) and is added in slant tube, blows repeatedly
It inhales, washes lower lawn.Then, washing lotion is moved in another sterile test tube with 5.0mL suction pipe, with electronic vortex mixer mixing 20s, or
Rapping 80 times on palm, so that bacterial suspension is uniform.Bacteria suspension made of preliminary, first with the bigness scale of bacterial concentration nephelometry its
Containing bacteria concentration, then with diluted to required concentration.
2, bacteriostatic test
(1) preparation of bacteria inhibition tablet
Experimental group: taking sterile and dry filter paper, and every is added dropwise Examples 1 to 6 plant compound bacteriostatic hand sanitizer respectively
About 5 μ L, then lie against filter paper in clean sterilized petri dishes, uncap to set in constant incubator (37 DEG C) and dry, or set room
It is spare after the lower natural drying of temperature.
Control group: taking sterile and dry filter paper, and every is added dropwise about 5 μ L of 1~6 hand cleanser of comparative example respectively, then will
Filter paper is lain against in clean sterilized petri dishes, is uncapped to set in constant incubator (37 DEG C) and be dried, or sets and spontaneously dry at room temperature
It is spare afterwards.
Negative control group: sterile and dry filter paper, every about 5 μ L of dropwise addition sterile distilled water, then by filter paper are taken
Lie against in clean sterilized petri dishes, uncap to set in constant incubator (37 DEG C) and dry, or set at room temperature spontaneously dry after it is spare.
(2) inoculation of test organisms
Dipping concentration with sterile cotton swab is 5 × 105Cfu/mL~5 × 106Cfu/mL tests bacteria suspension, in nutrient agar
It uniformly smears 3 times on culture medium flat plate surface.Every to smear 1 time, plate should rotate 60 °, finally smear cotton swab around plate edge
One week.Plate is covered, drying at room temperature 5min is set.
(3) bacteriostatic agent print is placed with
Test is placed with 1 microbiological contamination plate every time, and each plate is placed with 4 test prints, 1 negative control print, and totally 5
Piece.It is placed with aseptic nipper coupongs in planar surface.At a distance of 25mm or more between each print center, apart with the periphery of plate
15mm or more.After being placed with, with the light pressure-like piece of aseptic nipper, it is made to be tightly attached to planar surface.Plate is covered, 37 DEG C of constant temperature trainings are set
Case is supported, culture 16h~18h observes result.With the diameter (including patch) of vernier caliper measurement antibacterial ring size and record.Test repeats
3 times, record and calculate average value.
3, evaluation regulation
(1) bacteriostasis judges
Inhibition zone diameter is greater than 7mm person, has been judged to bacteriostasis；Inhibition zone diameter is less than or equal to 7mm person, is judged to no suppression
Bacterium effect.
(2) 3 repetition tests (totally 12 prints), which reach, bacteriostasis result person, is judged to qualification.
(3) negative control group should be generated without antibacterial ring size, and otherwise test is invalid.
4, result
From bacteriostatic test result (table 5 and table 6) as can be seen that 1~6 plant compound bacteriostatic hand sanitizer pair of the embodiment of the present invention
Staphylococcus aureus, Escherichia coli and Candida albicans have certain inhibiting effect, and wherein example 1 group hand cleanser is antibacterial
Effect is best；Although 1~6 hand cleanser of comparative example has inhibiting effect to 3 kinds of bacterium, effect is not so good as Examples 1 to 6；Negative control
Group is to 3 kinds of bacteriums without fungistatic effect.
Bacteriostatic diameter (mm) of the 5 Examples 1 to 6 plant compound bacteriostatic hand sanitizer of table to different bacterium
The bacteriostatic diameter (mm) of 6 comparative example of table, 1~6 hand cleanser and negative control group to different bacterium
The evaluation of 4 using effect of application examples
30 testers are equally divided into 6 groups, give test group sample at random by " double blind " test, it is desirable that tester
It washes one's hands (i.e. hand cleanser dosage, Handwashing ways, flushing period is without limitation) by itself daily habit of washing one's hands, successively evaluates hand cleanser
Foaming characteristic, dirt-removing power, irritation when washing one's hands rinse difficulty and salubrious sense of washing one's hands.Tester carries out according to the feeling of oneself
Scoring, standards of grading using 5 points of systems, wherein foaming characteristic, dirt-removing power, wash after salubrious sense it is worst with 1 point, 5 points preferably calculate；Thorn
It is best with 1 point to swash property, flushing difficulty, 5 points of worst calculating record the sensory effects scoring of each embodiment finally with mean values,
It see the table below shown in 7.
The using effect evaluation (unit: dividing) of 7 hand cleanser hand-washing effect of table
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of shield range can also be made on the basis of above description and thinking for those of ordinary skill in the art
Other various forms of variations or variation, there is no necessity and possibility to exhaust all the enbodiments.It is all of the invention
Made any modifications, equivalent replacements, and improvements etc., should be included in the protection of the claims in the present invention within spirit and principle
Within the scope of.
Claims (10)
1. a kind of plant compound bacteria inhibiting composition, which is characterized in that the plant compound bacteria inhibiting composition by Saponaria officinalis extract,
Fructus Citri grandis extract, Andrographis Paniculata, Radix Flemingiae Philippinensis extract, cherokee rose root extract and angelica extract composition.
2. plant compound bacteria inhibiting composition according to claim 1, which is characterized in that in the plant compound bacteria inhibiting composition
Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, Radix Flemingiae Philippinensis extract, cherokee rose root extract and angelica extract
Weight ratio is (1~5): (1~5): (1~5): (1~5): (1~5): (1~5).
3. plant compound bacteria inhibiting composition according to claim 2, which is characterized in that in the plant compound bacteria inhibiting composition
Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, Radix Flemingiae Philippinensis extract, cherokee rose root extract and angelica extract
Weight ratio is 1:1:1:1:1:1.
4. any one of claims 1 to 3 plant compound bacteria inhibiting composition is preparing the application in antibacterial daily chemical products.
5. applying according to claim 4, which is characterized in that the antibacterial daily chemical products are bacteriostatic hand sanitizer, antibacterial shower
Dew or bacteriostatic lotion.
6. a kind of plant compound bacteriostatic hand sanitizer, which is characterized in that include the plant compound suppression of any one of claims 1 to 3
Bacteria composition.
7. plant compound bacteriostatic hand sanitizer according to claim 6, which is characterized in that the plant compound bacteriostatic hand sanitizer by
The each group of following parts by weight is grouped as: 60~70 parts of deionized water, 8~12 parts of laureth sodium sulfovinate, and lauroyl flesh
1.5~2.0 parts of propylhomoserin sodium, 0.1~0.5 part of lauroyl arginine ethyl ester, cocoyl -5~15 parts of glucoside tartrate sodium, coconut palm
3~6 parts of oleamide propyl betaine, 2~7 parts of lauroyl glutamate TEA salt, 0.1~0.5 part of Sensiva SC50, camellia
0.01~0.05 part of seed oil, 0.01~0.05 part of peony seed oil, 0.01~0.05 part of oil and fat of sacha inchi, PPG-26 butylol polyether -26/
0.01~0.03 part of Cremophor RH40/water, 0.01~0.05 part of Saponaria officinalis extract, Fructus Citri grandis extract 0.01~
0.05 part, 0.01~0.05 part of Andrographis Paniculata, 0.01~0.05 part of Radix Flemingiae Philippinensis extract, cherokee rose root extract 0.01~
0.05 part, 0.01~0.05 part of angelica extract, 0.1~0.2 part of DMDMH, 0.2~0.6 part of potassium sorbate, tea tree ethereal oil
0.02~0.03 part, 0.02~0.03 part of grapefruit essential oil, 0.001~0.01 part of Bergamot, 0.4~0.8 part of essence, lemon
0.5~1.0 part of lemon acid.
8. plant compound bacteriostatic hand sanitizer according to claim 7, which is characterized in that the plant compound bacteriostatic hand sanitizer by
The each group of following parts by weight is grouped as: 62~67 parts of deionized water, 8~10 parts of laureth sodium sulfovinate, and lauroyl flesh
1.6~1.9 parts of propylhomoserin sodium, 0.1~0.3 part of lauroyl arginine ethyl ester, cocoyl -5~10 parts of glucoside tartrate sodium, coconut palm
3~5 parts of oleamide propyl betaine, 2~6 parts of lauroyl glutamate TEA salt, 0.2~0.5 part of Sensiva SC50, camellia
0.01~0.05 part of seed oil, 0.01~0.05 part of peony seed oil, 0.01~0.05 part of oil and fat of sacha inchi, PPG-26 butylol polyether -26/
0.01~0.02 part of Cremophor RH40/water, 0.01~0.05 part of Saponaria officinalis extract, Fructus Citri grandis extract 0.01~
0.05 part, 0.01~0.05 part of Andrographis Paniculata, 0.01~0.05 part of Radix Flemingiae Philippinensis extract, cherokee rose root extract 0.01~
0.05 part, 0.01~0.05 part of angelica extract, 0.13~0.18 part of DMDMH, 0.2~0.5 part of potassium sorbate, tea tree ethereal oil
0.02~0.03 part, 0.02~0.03 part of grapefruit essential oil, 0.001~0.01 part of Bergamot, 0.4~0.6 part of essence, lemon
0.6~0.9 part of lemon acid.
9. plant compound bacteriostatic hand sanitizer according to claim 8, which is characterized in that the plant compound bacteriostatic hand sanitizer by
The each group of following parts by weight is grouped as: 64 parts of deionized water, 9 parts of laureth sodium sulfovinate, and sodium lauroyl sarcosine 1.8
Part, 0.2 part of lauroyl arginine ethyl ester, cocoyl -9 parts of glucoside tartrate sodium, 4 parts of Cocoamidopropyl betaine, the moon
4.5 parts of salt of osmanthus acyl glutamic acid TEA, 0.4 part of Sensiva SC50,0.01 part of camellia seed oil, 0.01 part of peony seed oil, U.S. rattan fruit
0.01 part of oil, 0.015 part of oil/water of PPG-26 butylol polyether -26/PEG-40 hydrogenated castor, 0.01 part of Saponaria officinalis extract, shaddock
0.01 part of berry extract, 0.01 part of Andrographis Paniculata, 0.01 part of Radix Flemingiae Philippinensis extract, 0.01 part of cherokee rose root extract, Radix Angelicae Sinensis
0.01 part of extract, 0.15 part of DMDMH, 0.3 part of potassium sorbate, 0.025 part of tea tree ethereal oil, 0.025 part of grapefruit essential oil, Buddhist
0.005 part of hand mandarin orange essential oil, 0.5 part of essence, 0.8 part of citric acid.
10. the preparation method of any one of claim 7 to the 9 plant compound bacteriostatic hand sanitizer, which is characterized in that including as follows
Step:
S1. deionized water, laureth sodium sulfovinate, sodium lauroyl sarcosine and lauroyl arginine ethyl ester are mixed in proportion
It closes uniformly, 10~15min is stirred under the conditions of 50~55 DEG C to being completely dissolved, obtains mixture A；
S2. object A to be mixed is cooled to 40~45 DEG C, and cocoyl-glucoside tartrate is successively added into mixture A in proportion
Sodium, Cocoamidopropyl betaine, lauroyl glutamate TEA salt and Sensiva SC50 stir 10~15min, must mix
Object B；
S3. first camellia seed oil, peony seed oil, oil and fat of sacha inchi, PPG-26 butylol polyether -26/PEG-40 hydrogenated castor oil/water are pressed
Ratio is uniformly mixed, and obtains mixture C；Mixture C is added in mixture B again, 10~15min of stirring to Material clear,
Obtain mixture D；
S4. Saponaria officinalis extract, Fructus Citri grandis extract, Andrographis Paniculata, philippine flemingia root is successively added into mixture D in proportion
Extract, cherokee rose root extract, angelica extract, DMDMH, potassium sorbate, tea tree ethereal oil, grapefruit essential oil, Bergamot
And essence, it stirs evenly；Citric acid is slowly repeatedly added again, after mixing evenly up to plant compound bacteriostatic hand sanitizer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811606300.9A CN109453086A (en) | 2018-12-26 | 2018-12-26 | A kind of plant compound bacteriostatic hand sanitizer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811606300.9A CN109453086A (en) | 2018-12-26 | 2018-12-26 | A kind of plant compound bacteriostatic hand sanitizer and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109453086A true CN109453086A (en) | 2019-03-12 |
Family
ID=65614988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811606300.9A Withdrawn CN109453086A (en) | 2018-12-26 | 2018-12-26 | A kind of plant compound bacteriostatic hand sanitizer and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109453086A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641675A (en) * | 2021-01-05 | 2021-04-13 | 湖南御家化妆品制造有限公司 | Blackhead removing composition, application and blackhead removing scrub skin cleaning cream |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004016236A1 (en) * | 2002-08-14 | 2004-02-26 | Fancl Corporation | Cosmetics |
| KR20100077693A (en) * | 2008-12-29 | 2010-07-08 | 주식회사 코리아나화장품 | Cosmetic composition comprising glyceryl caprylate and the extract from citrus grapefruit seed, bambusa vulgaris and pinus palustris leaf as preservatives |
| CN103585063A (en) * | 2013-11-12 | 2014-02-19 | 上海方木精细化工有限公司 | Andrographis hand sanitizer |
| CN104274578A (en) * | 2014-09-05 | 2015-01-14 | 株洲千金药业股份有限公司 | Traditional Chinese medicinal composition with antimicrobial and antiinflammation effects and preparation method thereof |
| WO2015117957A1 (en) * | 2014-02-07 | 2015-08-13 | Unilever N.V. | A topical composition |
| CN106138374A (en) * | 2016-08-12 | 2016-11-23 | 株洲千金药业股份有限公司 | The application in terms of preparation treatment disease of thymus gland medicine of gynecological's prescriptions worth thousand gold compositions combined with antibiotic |
-
2018
- 2018-12-26 CN CN201811606300.9A patent/CN109453086A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004016236A1 (en) * | 2002-08-14 | 2004-02-26 | Fancl Corporation | Cosmetics |
| KR20100077693A (en) * | 2008-12-29 | 2010-07-08 | 주식회사 코리아나화장품 | Cosmetic composition comprising glyceryl caprylate and the extract from citrus grapefruit seed, bambusa vulgaris and pinus palustris leaf as preservatives |
| CN103585063A (en) * | 2013-11-12 | 2014-02-19 | 上海方木精细化工有限公司 | Andrographis hand sanitizer |
| WO2015117957A1 (en) * | 2014-02-07 | 2015-08-13 | Unilever N.V. | A topical composition |
| CN104274578A (en) * | 2014-09-05 | 2015-01-14 | 株洲千金药业股份有限公司 | Traditional Chinese medicinal composition with antimicrobial and antiinflammation effects and preparation method thereof |
| CN106138374A (en) * | 2016-08-12 | 2016-11-23 | 株洲千金药业股份有限公司 | The application in terms of preparation treatment disease of thymus gland medicine of gynecological's prescriptions worth thousand gold compositions combined with antibiotic |
Non-Patent Citations (8)
| Title |
|---|
| 中山医学院《中药临床应用》编写组编: "《中药临床应用》", 31 March 1975, 广东人民出版社 * |
| 刘顺枝,等: "柚类果实提取物生理功能及综合利用研究进展", 《食品科学》 * |
| 梅全喜主编: "《现代中药药理与临床应用手册第3版》", 31 October 2016, 中国中医药出版社 * |
| 王建新主编: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
| 肖水平,等: "单面针茎不同极性部位抗菌及对MCF-7细胞抑制活性的研究", 《天然产物研究与开发》 * |
| 苗明三，等，主编: "《中药大辞典》", 30 June 2017, 山西科学技术出版社 * |
| 裘炳毅，等，编: "《现代化妆品科学与技术下》", 31 March 2016, 中国轻工业出版社 * |
| 陈信云，等，主编: "《中药学第3版》", 31 January 2017, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641675A (en) * | 2021-01-05 | 2021-04-13 | 湖南御家化妆品制造有限公司 | Blackhead removing composition, application and blackhead removing scrub skin cleaning cream |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109568206B (en) | Special antibacterial composition and lotion for women and preparation method thereof | |
| CN107349170B (en) | Folium artemisiae argyi mosquito-repelling itching-relieving floral water and preparation method thereof | |
| CN106214573B (en) | Medical disposable hand saver skin thimerosal of one kind and preparation method thereof | |
| CN105779165A (en) | Washing composition as well as preparation method and application of washing composition | |
| CN107536727A (en) | A kind of disposable skin of hand antimicrobial spume and preparation method thereof | |
| CN107028848A (en) | A kind of disinfection solution of disposable hand natural green | |
| JP2006512304A (en) | Skin cleansing composition and method of use | |
| CN103451032A (en) | Safe and environment-friendly tea seed washing powder and preparation method thereof | |
| CN113081928A (en) | Plant bacteriostatic gel and preparation method and application thereof | |
| CN116370390A (en) | Multifunctional skin cleaning composition containing biosurfactant and preparation method and application thereof | |
| CN110478293A (en) | A kind of disposable disinfection hand cleanser and preparation method thereof | |
| CN109512741A (en) | A kind of essential oil is washed one's hands condensation and preparation method thereof | |
| CN105779177B (en) | A kind of Chinese medicine sterilizing soap and preparation method thereof | |
| CN109498511A (en) | A kind of Ms's essential oil shower condensation and preparation method thereof | |
| CN104490679B (en) | A kind of composite bactericidal hand cleanser and preparation method thereof | |
| CN109010178B (en) | Shower gel and production process thereof | |
| CN108014032A (en) | A kind of hip pad wet tissue and preparation method thereof | |
| CN107522682A (en) | Chinese violet cumarin with anti-inflammatory antiseptic activity and its preparation method and application | |
| CN104815096A (en) | Nano composite skin disinfection emulsion and preparation method of same | |
| WO2005025587A1 (en) | Composition comprising ginkgolides and bilobalide | |
| CN109055047A (en) | A kind of mosquito-proof children laundry detergent | |
| CN109453086A (en) | A kind of plant compound bacteriostatic hand sanitizer and preparation method thereof | |
| CN106726780A (en) | A kind of women privates nurses shower cream | |
| CN106860175A (en) | A kind of inhibiting bacteria and diminishing inflammation mildy wash | |
| CN105999341A (en) | Preparation method and application of pure natural antibacterial resuscitation-inducing air fresher |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190312 |
|
| WW01 | Invention patent application withdrawn after publication |