CN109432483B

CN109432483B - Medical dressing for accelerating wound healing and preparation method and application thereof

Info

Publication number: CN109432483B
Application number: CN201811325930.9A
Authority: CN
Inventors: 车七石; 刘少辉; 李新霞
Original assignee: Guangzhou Rainhome Pharm and Tech Co Ltd
Current assignee: Guangzhou Rainhome Pharm and Tech Co Ltd
Priority date: 2018-11-08
Filing date: 2018-11-08
Publication date: 2021-11-12
Anticipated expiration: 2038-11-08
Also published as: CN109432483A

Abstract

The invention belongs to the field of medical materials, and provides a medical dressing for accelerating wound healing and a preparation method and application thereof, wherein the medical dressing comprises a reticular polyester fiber base material and a hydrocolloid component, and the hydrocolloid component comprises 15-30 parts by weight of chitosan, 10-20 parts by weight of sodium carboxymethylcellulose, 20-55 parts by weight of vaseline and 3-10 parts by weight of an anion additive. According to the invention, through the combination and proportioning of the negative ions, the antibacterial components, the vitamins and the calcium ions, the components have synergistic effect, the antibacterial effect is enhanced, the metabolism of wound tissue cells is improved, scars are lightened, and the healing of the wound is remarkably accelerated.

Description

Medical dressing for accelerating wound healing and preparation method and application thereof

Technical Field

The invention belongs to the field of medical materials, relates to a medical dressing, a preparation method and application thereof, in particular to a medical dressing for accelerating wound healing, a preparation method and application thereof, and particularly relates to a medical dressing for resisting bacteria, inhibiting scars and promoting wound healing, a preparation method and application thereof.

Background

The medical dressing is a medical material used for temporarily covering the surfaces of various wounds and wounds, can avoid the influence of wound infection or other external factors, protect the wounds and promote the healing of the wounds. The commercially available hemostatic dressing is generally a simple dressing formed by common non-woven fabric and an adhesive layer, and mainly achieves the purpose of hemostasis by absorbing exudates such as wound blood and the like, and medicines are required to be matched for treatment or disinfection when necessary. Although conventional dressings such as gauze and bandage can meet the function of absorbing seepage, the dressing has many defects at the same time, such as poor hygroscopicity, easy bacterial infection on the surface of the dressing absorbing seepage, easy wound adhesion caused by long-time dressing on the surface of a wound, great difficulty in dressing change, increased pain of patients, and time and material waste.

CN103305963A discloses an application of chitin health care fiber capable of releasing negative ions and far infrared rays and a preparation method thereof, which is characterized in that the chitin health care fiber is prepared by the following raw materials by weight: chitin: 20-60 parts of; sodium alginate (gelatin): 30-60 parts of; and (3) negative ion additive: 0.5-10; auxiliary agent: 1 to 15; coconut shell carbon fiber: 0-10. The chitin health-care fiber with the functions of releasing negative ions and far infrared rays, which is prepared by the method, not only has the biodegradability, biocompatibility and bioactivity of chitin, but also can release negative ions called as 'air vitamins' or 'longevity elements' and dilate capillaries of people, promote blood circulation, strengthen metabolism among tissues, increase the regeneration capacity of the tissues, improve the immunity of organisms, adjust the abnormal excitation state of spirits, and play a role in medical care. The product has effects in regulating air quality of surrounding environment, generating far infrared ray absorbable by human body, activating human body cell, promoting microcirculation, improving human body function, and enhancing immunity.

CN107951945A discloses an external traditional Chinese medicine gel dressing, which is characterized by consisting of hydrogel and traditional Chinese medicine powder uniformly dispersed in the hydrogel; the traditional Chinese medicine powder comprises, by weight, 25-30 parts of henbane seed, 25-30 parts of amur corktree bark and 3-5 parts of borneol, and the hydrogel is prepared from 25 parts of sodium carboxymethylcellulose, 0.45 part of ethylparaben, 10 parts of propylene glycol, 0.6 part of urea, 10 parts of mannitol, 10 parts of ascorbic acid and 23 parts of glycerol. The external traditional Chinese medicine gel dressing is used for treating skin ulcer and bedsore, is safe and effective, can quickly promote the healing of the wound surfaces of the skin ulcer and the bedsore, but has poor stability of traditional Chinese medicine components and influences the dressing effect.

CN106975101A discloses a tourmaline/chitosan hydrochloride composite spraying type aqueous dressing, belonging to the technical field of composite aqueous wound dressings. The invention aims to solve the technical problem of providing a composite spraying type aqueous dressing which is suitable for the field of wound dressings. In the composite spraying type aqueous dressing, chitosan hydrochloride plays roles in blood coagulation and hemostasis, antibiosis and antiphlogosis and film formation; the tourmaline has the functions of emitting far infrared rays, generating negative ions, promoting cell growth and wound healing; a small amount of accessory polyvinylpyrrolidone (PVP) in the ethanol solution plays the role of a film forming agent, a dispersing agent and an adhesive. The prepared composite spraying type aqueous dressing is convenient to use, has small irritation to skin and high film forming speed, has good antibacterial, anti-inflammatory, blood coagulation and hemostasis effects, can emit far infrared rays and generate negative ions, promotes cell growth and wound healing, has good air permeability and moisture permeability after film forming, and can be used as a biological wound dressing. However, the concentration of negative ions generated by the induction of the tourmaline in the dressing is low, and the dressing has poor elasticity and weak seepage management capability.

Therefore, the medical dressing which has good antibacterial effect, good biocompatibility, good self-adhesion and stable effect and can quickly promote the healing of the wound surface has important significance and wide market prospect.

Disclosure of Invention

Aiming at the defects and actual requirements of the prior art, the invention provides the medical dressing for accelerating wound healing and the preparation method and application thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

according to a first aspect, the invention provides a medical dressing for accelerating wound healing, which comprises a reticular polyester fiber base material and a hydrocolloid component, wherein the hydrocolloid component comprises 15-30 parts by weight of chitosan, 10-20 parts by weight of sodium carboxymethylcellulose, 20-55 parts by weight of vaseline and 3-10 parts by weight of an anion additive.

According to the invention, chitosan, sodium carboxymethylcellulose, vaseline and an anion additive are combined, under the coordination of the components in parts by weight, the formed hydrocolloid has good capability of managing seepage, the dressing has high binding degree with a wound surface, and does not adhere to the wound, and the anion additive is used for promoting local microcirculation of the wound surface, stimulating a metabolic pathway and accelerating the healing of the wound surface.

Preferably, the hydrocolloid component comprises 15-30 parts of chitosan, 10-20 parts of sodium carboxymethyl cellulose, 20-55 parts of vaseline and 3-10 parts of an anion additive in parts by weight.

The mass fraction of the chitosan is 15-30 parts, for example, 15 parts, 18 parts, 20 parts, 22 parts, 24 parts, 25 parts, 27 parts, 29 parts or 30 parts, preferably 20-25 parts.

The weight portion of the sodium carboxymethylcellulose is 10-20 parts, for example, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts or 20 parts, preferably 15-20 parts.

In the invention, within the weight part range of the chitosan and the sodium carboxymethyl cellulose, the formed hydrocolloid has good elasticity and strong adaptability, can be attached to a wound surface, absorbs seepage, keeps the wound surface moist and promotes the healing of the wound surface.

The weight portion of the vaseline is 20 to 55 portions, for example, 20 portions, 25 portions, 30 portions, 35 portions, 40 portions, 45 portions, 50 portions or 55 portions, and preferably 30 to 40 portions.

The weight portion of the anion additive is 3-10 parts, for example, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts, preferably 5-8 parts.

Preferably, the hydrocolloid component further comprises an antimicrobial component, vitamins and calcium ions.

The negative ion additive is commonly used in cosmetics, can promote skin metabolism, improve blood circulation, effectively remove the melanin of the skin, eliminate facial dirt and exfoliated epidermal cells, and reduce wrinkles.

Preferably, the hydrocolloid component further comprises 3-8 parts of an antibacterial component, 1-5 parts of vitamin and 0.1-1 part of calcium ions in parts by weight.

According to the invention, the negative ions and the calcium ions in the weight ratio range can synergistically promote the microcirculation of the wound surface, regulate the metabolic pathway of the wound surface tissue and accelerate the healing of the wound, and both the negative ions and the calcium ions have the effect of promoting the metabolism, but the weight ratio of the negative ions or the calcium ions used alone is too high, so that the metabolic load of cells is increased, the two components can synergistically enhance according to the weight ratio of the two components, and the dosage of the two components is reduced without influencing the normal metabolic activity of tissue cells.

The weight portion of the antibacterial component is 3-8 parts, and can be 3 parts, 4 parts, 5 parts, 6 parts, 7 parts or 8 parts, for example.

The weight portion of the vitamin is 1-5 parts, for example, 1 part, 2 parts, 3 parts, 4 parts or 5 parts.

The calcium ion is 0.1-1 part by weight, and may be 0.1 part, 0.3 part, 0.5 part, 0.8 part or 1 part, for example.

Preferably, the antimicrobial component comprises any one of or a combination of at least two of nanosilver, a.sap, zinc oxide, epsilon-polylysine, or silver-loaded titanium dioxide, preferably a.sap.

In the invention, the A.SAP is a natural organic spectrum antibacterial component, has good antibacterial effect on various bacteria such as escherichia coli, candida, pneumonia feeling, mould, pseudomonas aeruginosa and the like, has lower toxicity and stronger effect than the traditional antibacterial component, and preferably has the antibacterial component, the A.SAP is synergistic with chitosan in a hydrocolloid component, the antibacterial effect can be exerted only by singly using the chitosan with the content of more than 90 percent, but the high-content chitosan is not beneficial to the formation of hydrocolloid, the economic cost is high, and the chitosan and the A.SAP can generate the synergistic antibacterial effect under the matching of the weight parts, so the dressing antibacterial effect is improved, and the multiple protection of wound surfaces is realized.

Preferably, the vitamin comprises any one of vitamin a, vitamin C or vitamin E or a combination of at least two of the foregoing, preferably a combination of vitamin a and vitamin C.

Preferably, the mass ratio of vitamin A to vitamin C is 1 (1-3), and may be, for example, 1:1, 1:2, or 1: 3.

In the invention, the vitamin A and the vitamin C are used in combination and have synergistic effect with the anion additive, and the scar can be effectively prevented and the wound healing can be promoted within the mass ratio range.

Preferably, the calcium ions comprise calcium chloride and/or nano calcium carbonate.

In the invention, calcium ions and negative ions have the effect of promoting microcirculation of the wound surface, but within the matching range of the parts by weight, the wound surface has high healing speed, shallow scars and good recovery condition of the wound surface.

In a second aspect, the present invention provides a method of making a medical dressing as described in the first aspect, the method comprising the steps of:

(1) heating and softening the vaseline to obtain liquid vaseline;

(2) adding sodium carboxymethylcellulose and chitosan into the liquid vaseline obtained in the step (1), mixing and stirring, heating for melting, and defoaming in vacuum;

(3) coating the vacuum defoamation melt obtained in the step (2) on a reticular polyester fiber base material to obtain a base material net;

(4) and (4) preparing the anion additive, the antibacterial component, the vitamin and the calcium ion into bioactive microspheres, and spraying the bioactive microspheres on the base material net in the step (3) to obtain the medical dressing.

Preferably, the heating temperature in step (1) is 120-.

Preferably, the temperature of the heating in step (2) is 120-150 ℃, and may be, for example, 120 ℃, 130 ℃, 140 ℃ or 150 ℃.

Preferably, the preparation method of the bioactive microsphere comprises the following steps:

(1') dissolving the anion additive, the antibacterial component, the vitamins, the calcium ions and the polyethylene glycol 400 in deionized water to obtain an internal water phase W1; adding a lactic acid-glycolic acid copolymer into a dichloromethane-acetone mixture to obtain an oil phase O; taking the aqueous solution of polyvinyl alcohol as an external water phase W2;

(2') adding an internal water phase W1 into the oil phase O, and performing ultrasonic treatment in ice bath to obtain primary emulsion W1/O;

(3 ') adding the primary emulsion W1/O in the step (2') into an external water phase W2, and stirring under ice bath to obtain double emulsion W1/O/W2;

(4 ') adding the multiple emulsion W1/O/W2 obtained in the step (3') into a sodium chloride solution, volatilizing the solvent, and filtering to obtain the bioactive microspheres.

Preferably, the bioactive microspheres in step (4') have a particle size of 20-50 μm, such as 20 μm, 30 μm, 40 μm or 50 μm.

In a third aspect, the present invention provides the use of a medical dressing as described in the first aspect for the manufacture of a medicament and/or agent for the treatment of a surgical wound.

Compared with the prior art, the invention has the following beneficial effects:

(1) according to the invention, sodium carboxymethylcellulose and chitosan are used as main components of the hydrocolloid, the hydrocolloid obtained according to the weight ratio has better moisture retention performance, can quickly absorb seepage, reduce the replacement times of medical dressing, reduce the pain of a patient, and can generate corresponding deformation according to the condition of a wound surface, so that the hydrocolloid oily gauze has better fitting degree with the wound surface, and the anion additive obviously improves the microcirculation of the wound surface and promotes the healing of the wound surface;

(2) according to the invention, through the combination and proportioning of the negative ions, the antibacterial components, the vitamins and the calcium ions, the components have synergistic effect, the antibacterial effect is enhanced, the metabolism of wound tissue cells is improved, scars are lightened, and the healing of the wound is remarkably accelerated.

Detailed Description

To further illustrate the technical means and effects of the present invention, the following embodiments further illustrate the technical solutions of the present invention, but the present invention is not limited to the scope of the embodiments.

Example 1

A medical dressing for accelerating wound healing comprises a reticular polyester fiber base material and a hydrocolloid component, wherein the hydrocolloid component comprises the following components in parts by weight:

the mass ratio of the vitamin A to the vitamin C is 1: 2;

the preparation method of the medical dressing comprises the following steps:

(1) heating vaseline to 150 deg.C for softening to obtain liquid vaseline;

(2) adding sodium carboxymethylcellulose and chitosan into the liquid vaseline obtained in the step (1), mixing and stirring, heating to 140 ℃ for melting, and defoaming in vacuum;

(4) preparing a bioactive microsphere from the anion additive, the antibacterial component, the vitamin and calcium ions, and spraying the bioactive microsphere on the base material net in the step (3) to obtain the medical dressing;

wherein the particle size of the bioactive microsphere is 30 μm.

Example 2

wherein the mass ratio of the vitamin A to the vitamin C is 1: 2;

the preparation method of the medical dressing comprises the following steps:

(1) heating vaseline to 160 deg.C for softening to obtain liquid vaseline;

(2) adding sodium carboxymethylcellulose and chitosan into the liquid vaseline obtained in the step (1), mixing and stirring, heating to 130 ℃ for melting, and defoaming in vacuum;

wherein the particle size of the bioactive microsphere is 40 μm.

Example 3

wherein the mass ratio of the vitamin A to the vitamin C is 1: 1;

the preparation method of the medical dressing comprises the following steps:

(1) heating vaseline to 180 deg.C for softening to obtain liquid vaseline;

(2) adding sodium carboxymethylcellulose and chitosan into the liquid vaseline obtained in the step (1), mixing and stirring, heating to 120 ℃ for melting, and defoaming in vacuum;

Wherein the particle size of the bioactive microsphere is 20 μm.

Example 4

wherein the mass ratio of the vitamin A to the vitamin C is 1: 3;

the preparation method of the medical dressing comprises the following steps:

(1) heating vaseline at 120 deg.C to soften vaseline to obtain liquid vaseline;

(2) adding sodium carboxymethylcellulose and chitosan into the liquid vaseline obtained in the step (1), mixing and stirring, heating to 150 ℃ for melting, and defoaming in vacuum;

Wherein the particle size of the bioactive microsphere is 50 μm.

Example 5

Compared with the example 1, the conditions are the same as the example 1 except that the weight part of the negative ion additive is 1 part.

Example 6

Compared with the example 1, the conditions are the same as the example 1 except that the weight part of the negative ion additive is 15 parts.

Example 7

Compared with the embodiment 1, the other conditions are the same as the embodiment 1 except that the antibacterial component is nano silver.

Example 8

The procedure is as in example 1 except that no vitamin A is added, as compared with example 1.

Example 9

The procedure of example 1 was followed except that vitamin C was not added, as compared with example 1.

Example 10

The procedure of example 1 was repeated except that the mass ratio of vitamin A to vitamin C was 3: 1.

Example 11

The procedure of example 1 was repeated except that the mass ratio of vitamin A to vitamin C was 1: 5.

Example 12

The procedure of example 1 was followed except that calcium ions were not added, as compared with example 1.

Example 13

The procedure of example 1 was followed except that the bioactive microsphere had a particle size of 5 μm as compared with example 1.

Example 14

The procedure of example 1 was followed except that the bioactive microsphere had a particle size of 60 μm, as compared with example 1.

Comparative example 1

Compared with the example 1, the conditions are the same as the example 1 except that the weight portion of the chitosan is 10 parts, the weight portion of the sodium carboxymethyl cellulose is 30 parts, and the weight portion of the vaseline is 25 parts.

Comparative example 2

Compared with the example 1, the conditions are the same as the example 1 except that the weight portion of the chitosan is 40 parts, the weight portion of the sodium carboxymethyl cellulose is 10 parts, and the weight portion of the vaseline is 25 parts.

Comparative example 3

Compared with the example 1, the conditions are the same as the example 1 except that the weight parts of the chitosan are 20 parts, the weight parts of the sodium carboxymethyl cellulose are 15 parts, and the weight parts of the collagen polypeptide are 10 parts.

Comparative example 4

Compared with example 1, the conditions are the same as example 1 except that the negative ion additive is not added.

Comparative example 5

The same procedure as in example 1 was repeated except that chitosan was not added, as compared with example 1.

Comparative example 6

The experiment was performed using plain petrolatum gauze without any functional ingredients.

Study of Properties

1. Biological performance research of medical dressing for antibacterial promotion of wound healing

Reference is made to GB/T16886.1-2001 medical device biology evaluation part 1: evaluation and experiment, GB/T16886.10-2005 medical device biology evaluation part 10: stimulation and delayed type hypersensitivity experiments, GB/T16886.5-2003 part 5 of medical device biology evaluation: in vitro cytotoxicity test and related standards the medical dressing of example 1 of the present invention was biologically studied.

(1) Skin irritation test

Taking samples according to 3cm²Adding leaching medium meeting the requirement of 10.3.4 in GB/T16886.12-2005 in the proportion of/mL, leaching (24 +/-2) h at the temperature of (37 +/-1) to prepare leaching liquor,the test method after filtration through a funnel was carried out as specified in B.2 of appendix B of GB/T16886.10-2005. The result is that the rabbit skin Primary Irritation Index (PII) of the medical dressing is 0 and has no irritation.

(2) In vitro cytotoxicity assay

Taking samples according to 3cm²The cell culture solution is added into the mixture at a ratio of/mL, leaching (24 +/-2) is carried out at a temperature of (37 +/-1) ℃ to prepare a leaching solution, and the leaching solution is filtered by a funnel and then the test method is carried out according to the specification of 8.2 in GB/T16886.5-2003. The results show that the cytotoxicity response of the medical dressing is 0 on average and has no cytotoxicity.

(3) Delayed type hypersensitivity test

Taking samples according to 3cm²Adding a leaching medium meeting the requirement of 10.3.4 in GB/T16886.12-2005 in a/mL ratio, leaching (24 +/-2) h at the temperature of (37 +/-1) to prepare a leaching solution, and performing a test method after filtering by using a funnel according to the specification of 7 in GB/T16886.10-2005. The result shows that the average sensitization score of the medical dressing is 0 and the medical dressing has no sensitization.

2. Animal experiment verification of medical dressing for antibacterial promotion of wound healing

(1) Skin wound repair test:

selecting 120 male big-ear white rabbits with the weight of about 2kg, injecting 25% urethane from the ear vein at a ratio of 1g/kg before experiment, enabling animals to enter an anesthesia state, removing hairs and preparing skin on the back for disinfection, cutting 1 circular wound along two sides of a spine by using a scalpel, cutting off subcutaneous tissues to fascia, stopping bleeding, wrapping sterile gauze, and feeding in cages; after the following day of surgery, the rabbits were divided into 20 groups of 6 animals each, and the animals of each group were applied with the medical dressings of examples 1 to 14 and comparative examples 1 to 6, respectively, and the areas of the wounds on days 0 and 7 and the frequency of dressing changes were recorded, respectively, as shown in table 1.

TABLE 1 wound repair test results

As can be seen from table 1, comparing example 1 with examples 5-6, it can be seen that too much amount of the negative ion additive increases the metabolic load of the wound surface, increases the exudate, prolongs the healing time of the wound surface, too little amount of the negative ion additive, insufficient release amount of negative ions, fails to exert effective synergistic effect with vitamins and calcium ions, and significantly reduces the performance of the medical dressing; comparing example 1 with example 7, it can be seen that the a.sap, as a preferred antimicrobial component, inhibits microbial proliferation, maintains a sterile environment for the wound surface, and promotes healing; comparing example 1 with examples 8-11, it can be seen that vitamin a and vitamin C in the mass ratio range can cooperate with negative ions to lighten scars and promote wound healing; comparing example 1 with example 12, it can be seen that calcium ions and the negative ion additive have synergistic effect, so that the microcirculation of the wound surface is remarkably promoted, the absorption and metabolism of active ingredients in the dressing are accelerated, and the healing of the wound surface is accelerated; comparing example 1 with examples 13-14, it can be seen that the particle size of the bioactive microspheres is too small or too large to affect the synergistic release of negative ions, antimicrobial components, vitamins and calcium ions; comparing example 1 with comparative examples 1-3, it can be seen that chitosan, sodium carboxymethylcellulose and vaseline have the best effect within the weight portion range of the invention, excessive chitosan or sodium carboxymethylcellulose affects the elasticity of hydrocolloid, and too little vaseline easily causes the dressing to adhere to the wound surface; comparing example 1 with comparative examples 4-6, it can be seen that the healing speed of the wound surface is remarkably slowed down without adding the negative ion additive, and the common vaseline oil yarn can only keep the wound surface moist, and has no obvious influence on the healing speed of the wound surface.

3. Antibacterial test

Activated staphylococcus aureus, escherichia coli and pseudomonas aeruginosa are inoculated on an agar plate of a common broth culture medium, cultured for 24 hours at 37 ℃, the thalli are properly diluted by nutrient broth, the medical dressing of the invention in the examples 1-7 and 12 and the comparative examples 4-6 is added, the incubation is carried out for 60 minutes at normal temperature, 50 mu L of the medical dressing is respectively taken for plate coating, the inversion culture is carried out for 24 hours at 37 ℃, the growth condition of bacterial colonies is observed, sterile water is used for replacing the medical dressing as a blank control, and the bacteriostasis rate of each example and the comparative example is calculated, and the results are shown in table 2.

TABLE 2 results of the bacteriostatic test

As can be seen from Table 2, comparing example 1 with examples 5-6, the amount of the negative ion additive affects the antibacterial effect of the medical dressing, and the antibacterial rate is reduced too much or somewhat; comparing example 1 with example 7, it can be seen that the synergistic effect of the negative ion additive and the a.sap is more significant, and the antibacterial effect of the nano silver is not as good as that of the a.sap; comparing example 1 with example 12, it can be seen that the negative ions and the calcium ions are synergistic, and the antibacterial rate is remarkably improved; comparing example 1 with comparative example 4, it can be seen that the negative ions have synergistic effect with the antibacterial component, vitamins, calcium ions, and the dressing efficacy is significantly reduced without adding the negative ion additive; comparing example 1 with comparative example 5, it can be seen that the antibacterial property of the dressing is reduced without adding chitosan, and meanwhile, the elasticity and biocompatibility of the hydrocolloid are reduced; comparing example 1 with comparative example 6, it can be seen that the common hydrocolloid oil gauze only plays a role of moisturizing, but has a poor bacteriostatic effect.

In conclusion, the sodium carboxymethyl cellulose and the chitosan are used as main components of the hydrocolloid, the hydrocolloid obtained according to the weight ratio has better moisture retention performance, can quickly absorb seepage, reduce the replacement frequency of medical dressings, reduce the pain of patients, can generate corresponding deformation according to the condition of a wound surface, enables hydrocolloid oily gauze to be better in fitting degree with the wound surface, combines and ratios negative ions, antibacterial components, vitamins and calcium ions, and the components have synergistic interaction, enhance the antibacterial effect, improve the cell metabolism of the tissue cells of the wound surface, lighten scars and obviously accelerate the healing of the wound surface.

The applicant states that the present invention is illustrated in detail by the above examples, but the present invention is not limited to the above detailed methods, i.e. it is not meant that the present invention must rely on the above detailed methods for its implementation. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

Claims

1. The medical dressing for accelerating wound healing is characterized by comprising 15-30 parts of chitosan, 10-20 parts of sodium carboxymethylcellulose, 20-55 parts of vaseline, 3-10 parts of an anion additive, 3-8 parts of an antibacterial component, 1-5 parts of vitamin and 0.1-1 part of calcium ions in parts by weight;

the vitamin is the combination of vitamin A and vitamin C;

the mass ratio of the vitamin A to the vitamin C is 1 (1-3);

the medical dressing is prepared by adopting the following method, and the method comprises the following steps:

(1) heating and softening the vaseline to obtain liquid vaseline;

the particle size of the bioactive microsphere is 20-50 μm.

2. The medical dressing according to claim 1, wherein the hydrocolloid component comprises, by weight, 20-25 parts of chitosan, 15-20 parts of sodium carboxymethylcellulose, 30-40 parts of vaseline, 5-8 parts of an anion additive, 3-8 parts of an antibacterial component, 1-5 parts of vitamin and 0.1-1 part of calcium ions.

3. The medical dressing of claim 1, wherein the antimicrobial component comprises any one of or a combination of at least two of nanosilver, a.sap, zinc oxide, epsilon-polylysine, or silver-loaded titanium dioxide.

4. The medical dressing of claim 3, wherein the antimicrobial component is A.SAP.

5. The medical dressing of claim 1, wherein the calcium ions comprise calcium chloride and/or nano calcium carbonate.

6. A method of making a medical dressing according to any one of claims 1 to 5, comprising the steps of:

(1) heating and softening the vaseline to obtain liquid vaseline;

7. The method as claimed in claim 6, wherein the heating temperature in step (1) is 120-180 ℃.

8. The method as claimed in claim 6, wherein the heating temperature in step (2) is 120-150 ℃.

9. The method of claim 6, wherein the preparation of the bioactive microsphere comprises the steps of:

10. The method of claim 9, wherein the bioactive microsphere of step (4') has a particle size of 20-50 μm.

11. Use of a medical dressing as claimed in any one of claims 1 to 5 in the manufacture of a medicament and/or agent for the treatment of surgical wounds.