CN109350124A - The continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer - Google Patents
The continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer Download PDFInfo
- Publication number
- CN109350124A CN109350124A CN201811399706.4A CN201811399706A CN109350124A CN 109350124 A CN109350124 A CN 109350124A CN 201811399706 A CN201811399706 A CN 201811399706A CN 109350124 A CN109350124 A CN 109350124A
- Authority
- CN
- China
- Prior art keywords
- blood vessel
- ultrasonic transducer
- information
- minimally
- measuring system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/04—Measuring blood pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0891—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/488—Diagnostic techniques involving Doppler signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/56—Details of data transmission or power supply
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Computer Networks & Wireless Communication (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
The invention discloses a kind of continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer, comprising: information acquisition module is used to acquire the information such as intravascular blood flow velocity, pipe diameter size and density of blood;Information pre-processing module with the information acquisition module bluetooth, wirelessly or electrically connect, and pre-processes to information such as blood flow velocity, pipe diameter size and density of blood;And information display module, it is electrically connected with the information pre-processing module;Wherein, the information acquisition module is miniprobe sonography, and the miniprobe sonography is directly arranged in arteries or vein blood vessel by trochar.The present invention has the beneficial effect of invasive continuous accurate measurements haemodynamics (artery/vein vascular pressure) variation.
Description
Technical field
The present invention relates to biomedical engineering fields.It is more particularly related to a kind of based on ultrasonic transducer
The continuous pressure measuring system of minimally-invasive blood vessel.
Background technique
Measurement blood pressure is the basic skills for understanding health condition and observing the state of an illness, especially during operation or in Intensive Care Therapy
Ward, the continuous dynamic (dynamical) variation of monitor blood flow is to all kinds of critical patients such as cardiovascular diseases, more it is necessary to hypertension/low
Blood pressure is the direct cause of death of many high-risk patients.The study found that between blood pressure change rate and the death rate of cardiovascular disease
There is significant correlation.Therefore, pass through that continuous hemodynamic monitoring grasps blood pressure change rate and take appropriate measures can be with
The occurrence of greatly reducing the fatal risk as caused by blood stream rheology.
With the development of science and technology, also occurring a kind of more accurately monitoring device as shown in Figure 1 at present.Such as Fig. 1 institute
Show, which includes pressure sensor 81, data line 82, flusher 83, diversion pipe 84, trochar 85, working principle
As follows: flusher 83 is externally connected to the physiological saline containing heparin, and flusher 83 is fixedly connected on pressure sensor 81
On, inner conduit is in contact with the induction zone inside pressure sensor 81, and export end is connected with diversion pipe 84, diversion pipe 84
It is connected on trochar 85;Pressure sensor 81 is connected with data line 82, and one end of the data line 82 is provided with coffret
So as to external analysis shows that instrument is connected.When monitoring starts, trochar 85 is punctured merging blood vessel, it is then that needle core is rapid
Extraction and casing 85 still remain in it is intravascular, 85 airtight connection of trochar on diversion pipe 84, flusher 83 at the same time
Interior heparin saline is also met in water conservancy diversion to diversion pipe 84 and close to one section of trochar 85 and the blood at upstream, in pressure
Under the action of balance, which finally remains unchanged.The pressure of induction zone with blood pressure is consistent on pressure sensor 81 at this time
's.It is the pressure (angiosthenia/vein pressure) of blood vessel by the pressure that pressure sensor 81 measures, and is transferred to by data line 82
Analysis shows that analyzed on instrument and show that result is recorded for medical staff, guiding clinical diagnosis and treatment.
Although above-mentioned disposable pressure sensor can accurately measure the blood pressure of patient, inside diversion pipe 84
Deflector hole it is excessively narrow, when backflow of blood to pipe in when it is easy to appear solidification the phenomenon that, this be just unfavorable for blood pressure carry out
Monitoring, pressure then cannot be accurately measured after blood clotting, needs to maintain blood in heparin saline fair current to diversion pipe 84
To prevent Hemostatic Oral Liquid solidification near 84 contact position of trochar 85 and diversion pipe, this just needs to add the flushing dress of water conservancy diversion heparin saline
83 are set, which adds cost, and it is inconvenient for operation.
Summary of the invention
For the shortcomings of the prior art, the object of the present invention is to provide a kind of based on the micro- of ultrasonic transducer
The continuous pressure measuring system of wound formula blood vessel surveys pressure for artery and vein surveys pressure, hence it is evident that saves material, reduce costs, using more
Pu Le test the speed calculation formula generate doppler waveform, the doppler waveform is being changing by pressure wave by specific mathematical model
Shape, being capable of invasive continuous accurate measurements haemodynamics (artery/vein vascular pressure) variation.
In order to realize these purposes and other advantages according to the present invention, provide a kind of based on the minimally invasive of ultrasonic transducer
The continuous pressure measuring system of formula blood vessel, comprising: information acquisition module is used to acquire intravascular blood flow velocity, pipe diameter size and blood
The information such as density;
Information pre-processing module with the information acquisition module bluetooth, is wirelessly or electrically connect, and to blood flow velocity, pipe
The information such as diameter size and density of blood are pre-processed;And
Information display module is electrically connected with the information pre-processing module;
Wherein, the information acquisition module is miniprobe sonography, and the miniprobe sonography is directly arranged in dynamic by trochar
In arteries and veins blood vessel or vein blood vessel.
Preferably, the information pre-processing module is ultrasonic transducer, by the blood flow velocity received, pipe diameter size
And the information such as density of blood are pre-processed, and are calculated formula by Doppler range rate measurement and are generated doppler waveform.
Preferably, the information display module is analysis shows that instrument, described analysis shows that instrument passes through specific mathematical model
The doppler waveform is changing into pressure waveform.
Preferably, the miniprobe sonography surface is coated with for preventing the thrombosed overlay film of blood clotting, described
Overlay film is through anticoagulation.
Preferably, after the miniprobe sonography merging blood vessel, described sleeve pipe needle be can be taken off, described super after monitoring
Sound miniature probe postoperative can take out.
Preferably, selection oar is dynamic when the continuous pressure measuring system artery of the minimally-invasive blood vessel based on ultrasonic transducer surveys pressure
Arteries and veins, femoral artery or other arteries are monitored, and the continuous pressure measuring system vein of the minimally-invasive blood vessel based on ultrasonic transducer is surveyed
Subclavian vein, jugular vein, femoral vein or other Deep veins is selected to be monitored when pressure.
Preferably, the site of puncture of patient must carry out Aseptic sterilisation processing.
Preferably, the miniprobe sonography or the conduit need to be fixed with fixed device.
The present invention is include at least the following beneficial effects: the minimally-invasive blood vessel provided by the invention based on ultrasonic transducer is continuous
Pressure measuring system is surveyed pressure for artery and vein surveys pressure, hence it is evident that saved material, reduce costs, calculated using Doppler range rate measurement
Formula generates doppler waveform, and the doppler waveform is being changing into pressure waveform by specific mathematical model, can be invasive
Continuous accurate measurements haemodynamics (artery/vein vascular pressure) variation.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Detailed description of the invention
Fig. 1 is the schematic diagram of disposable pressure sensor in the prior art;
Fig. 2 is structure diagram of the invention;
Fig. 3 is the structure diagram of one embodiment of the invention.
Specific embodiment
Present invention will be described in further detail below with reference to the accompanying drawings, foregoing end other objects of the invention, feature, side
Face and advantage will be apparent, and so that those skilled in the art can carry out according to the description.In the accompanying drawings,
For clarity, shape and size can be amplified, and will be indicated in all figures using identical appended drawing reference identical
Or similar component.In the following description, such as center, thickness, height, length, front, back, rear portion, the left side, the right, top
The words such as portion, bottom, top, lower part are to be based on the orientation or positional relationship shown in the drawings.Particularly, " height " is equivalent to from top
Portion is to the size of bottom, and " width " is equivalent to size from left to right, and " depth " is equivalent to vertical size.These
Relative terms are to be not intended to need specifically to be orientated for convenience and usually.It is related to the term of attachment, connection etc.
(for example, " connection " and " attachment ") refer to these structures by the relationship that intermediate structure is fixed directly or indirectly to one another or is attached,
And movable or rigidly attached or relationship, unless otherwise clearly stating.
As a specific embodiment of the invention, with reference to Fig. 1~3, the present invention provides one kind to be based on ultrasonic transducer
The continuous pressure measuring system of minimally-invasive blood vessel, comprising: information acquisition module is used to acquire intravascular blood flow velocity, pipe diameter size
And the information such as density of blood;
Information pre-processing module with the information acquisition module bluetooth, is wirelessly or electrically connect, and to blood flow velocity, pipe
The information such as diameter size and density of blood are pre-processed;And
Information display module is electrically connected with the information pre-processing module;
Wherein, the information acquisition module is miniprobe sonography 1, and the miniprobe sonography 1 is directly arranged in by trochar
In arteries or vein blood vessel.
Further, the information pre-processing module is ultrasonic transducer 2, by the blood flow velocity received, pipe diameter size
And the information such as density of blood are pre-processed, and are calculated formula by Doppler range rate measurement and are generated doppler waveform.
The information display module is analysis shows that instrument 3, described analysis shows that instrument 3 will be described more by specific mathematical model
General Le waveform is changing into pressure waveform.
Further, 1 surface of miniprobe sonography is coated with for preventing the thrombosed overlay film of blood clotting, described to cover
For film through anticoagulation, 1 surface of miniprobe sonography is smooth, after coating overlay film, can make the blood flow of the acquisition of miniprobe sonography 1
The information such as speed, pipe diameter size and density of blood are more accurate.
After the miniprobe sonography 1 is placed in blood vessel, described sleeve pipe needle be can be taken off, after monitoring, the miniprobe sonography 1
It postoperative can take out.
The minimally-invasive blood vessel based on ultrasonic transducer continuous pressure measuring system artery selects radial artery, femoral artery when surveying pressure
Or other arteries are monitored, selection lock when the continuous pressure measuring system vein of the minimally-invasive blood vessel based on ultrasonic transducer surveys pressure
Vein, jugular vein, femoral vein or other Deep veins are monitored under bone.The site of puncture of patient must carry out Aseptic sterilisation
Processing.The miniprobe sonography 1 or the conduit need to be fixed with fixed device.
As a specific embodiment of the invention, with reference to Fig. 3, the detection site of patient is subjected to sterilizing first,
After sterilizing, trochar is at an acute angle with skin, and after puncture, casing is sent for inserting needle parallel with artery or vein traveling
Enter artery or intravenous and be pushed into required depth, extract needle core, then by the miniprobe sonography 1 through casing be put into arteries or
It is connect with contacting blood, the miniprobe sonography 1 with 2 bluetooth of ultrasonic transducer, wirelessly or electrically in vein blood vessel, the ultrasound is micro-
After probe 1 directly collects the information such as artery or venous blood flow velocity, pipe diameter size and density of blood, by artery or venous blood flow
The information such as speed, pipe diameter size and density of blood are transmitted to the ultrasonic transducer 2, and the ultrasonic transducer 2 utilizes Doppler
How general the calculation formula that tests the speed and compensation formula generate the information such as artery or venous blood flow velocity, pipe diameter size and density of blood
Waveform is strangled, doppler waveform is transmitted to described analysis shows that instrument 3, described analysis shows that instrument 3 passes through by the ultrasonic transducer 2 again
The doppler waveform is changing into artery or vein pressure waveform by specific mathematical model, medical worker can clear view to patient
Artery or vein pressure information;Wherein, the miniprobe sonography 1 postoperative can take out.
Number of devices and treatment scale described herein are for simplifying explanation of the invention.To application of the invention,
Modifications and variations will be readily apparent to persons skilled in the art.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With.It can be applied to various suitable the field of the invention completely.It for those skilled in the art, can be easily
Realize other modification.Therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and legend shown and described herein.
Claims (8)
1. a kind of continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer characterized by comprising information collection mould
Block is used to acquire the information such as intravascular blood flow velocity, pipe diameter size and density of blood;
Information pre-processing module with the information acquisition module bluetooth, is wirelessly or electrically connect, and big to blood flow velocity, caliber
The information such as small and density of blood are pre-processed;And
Information display module is electrically connected with the information pre-processing module;
Wherein, the information acquisition module is miniprobe sonography, and the miniprobe sonography is directly arranged in arterial blood by trochar
In pipe or vein blood vessel.
2. the continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer as described in claim 1, which is characterized in that described
Information pre-processing module is ultrasonic transducer, and the information such as the blood flow velocity received, pipe diameter size and density of blood are carried out
Pretreatment calculates formula by Doppler range rate measurement and generates doppler waveform.
3. the continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer as described in claim 1, which is characterized in that described
Information display module is analysis shows that instrument, described analysis shows that the doppler waveform is changing by instrument by specific mathematical model
Pressure waveform.
4. the continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer as described in claim 1, which is characterized in that described
Miniprobe sonography surface is coated with for preventing the thrombosed overlay film of blood clotting, and the overlay film is through anticoagulation.
5. the continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer as described in claim 1, which is characterized in that described
After miniprobe sonography is placed in blood vessel, described sleeve pipe needle be can be taken off, and after monitoring, the miniprobe sonography postoperative can be taken out.
6. the continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer as described in claim 1, which is characterized in that described
When the continuous pressure measuring system artery of minimally-invasive blood vessel based on ultrasonic transducer surveys pressure selection radial artery, femoral artery or other arteries into
Row monitoring, the minimally-invasive blood vessel based on ultrasonic transducer continuous pressure measuring system vein select subclavian vein, neck when surveying pressure
Internal jugular vein, femoral vein or other Deep veins are monitored.
7. the continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer as described in claim 1, which is characterized in that patient
Site of puncture must carry out Aseptic sterilisation processing.
8. the continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer as described in claim 1, which is characterized in that described
Miniprobe sonography need to be fixed with fixed device.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811399706.4A CN109350124A (en) | 2018-11-22 | 2018-11-22 | The continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811399706.4A CN109350124A (en) | 2018-11-22 | 2018-11-22 | The continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109350124A true CN109350124A (en) | 2019-02-19 |
Family
ID=65338386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811399706.4A Pending CN109350124A (en) | 2018-11-22 | 2018-11-22 | The continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109350124A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116458925A (en) * | 2023-06-15 | 2023-07-21 | 山东百多安医疗器械股份有限公司 | Portable non-blind area multi-mode ultrasonic electrocardio system |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104883967A (en) * | 2012-11-08 | 2015-09-02 | 勒·泰 | Improved blood pressure monitor and method |
CN105722464A (en) * | 2013-11-13 | 2016-06-29 | 火山公司 | Visually optimized intravascular imaging and associated devices, systems, and methods |
CN107550519A (en) * | 2017-08-22 | 2018-01-09 | 深圳先进技术研究院 | A kind of Multifunctional blood intraductal ultrasonography imaging device |
CN107735032A (en) * | 2015-07-02 | 2018-02-23 | 皇家飞利浦有限公司 | Multi-mode electric capacity declines machined ultrasonic transducers and associated equipment, system and method |
-
2018
- 2018-11-22 CN CN201811399706.4A patent/CN109350124A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104883967A (en) * | 2012-11-08 | 2015-09-02 | 勒·泰 | Improved blood pressure monitor and method |
CN105722464A (en) * | 2013-11-13 | 2016-06-29 | 火山公司 | Visually optimized intravascular imaging and associated devices, systems, and methods |
CN107735032A (en) * | 2015-07-02 | 2018-02-23 | 皇家飞利浦有限公司 | Multi-mode electric capacity declines machined ultrasonic transducers and associated equipment, system and method |
CN107550519A (en) * | 2017-08-22 | 2018-01-09 | 深圳先进技术研究院 | A kind of Multifunctional blood intraductal ultrasonography imaging device |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116458925A (en) * | 2023-06-15 | 2023-07-21 | 山东百多安医疗器械股份有限公司 | Portable non-blind area multi-mode ultrasonic electrocardio system |
CN116458925B (en) * | 2023-06-15 | 2023-09-01 | 山东百多安医疗器械股份有限公司 | Portable non-blind area multi-mode ultrasonic electrocardio system |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20210259558A1 (en) | Haemodynamic data estimation | |
Schrope et al. | Second harmonic ultrasonic blood perfusion measurement | |
US8771195B2 (en) | Cardiovascular analyzer | |
Rushmer et al. | Transcutaneous Doppler flow detection as a nondestructive technique. | |
EP2429387B1 (en) | System and method of measuring changes in arterial volume of a limb segment | |
EP2593006B1 (en) | Method and apparatus for the non-invasive measurement of pulse transit times (ptt) | |
EP3203966B1 (en) | Device and method for measurement of intracranial pressure | |
US9297874B2 (en) | Apparatus and method for non-invasive measurement of cardiac output | |
CN109350125A (en) | The continuous pressure measuring system of noninvasive blood vessel based on ultrasonic transducer | |
JP2005312947A (en) | Method and apparatus for measuring blood volume, and vital sign monitor | |
CN101889861B (en) | Device for analyzing cardiovascular and cerebrovascular characteristics and blood characteristics | |
WO2000055579A2 (en) | A system and method for detection and characterization of stenosis, blood vessels flow and vessel walls properties using vessel geometrical measurements | |
Joseph et al. | Arterial compliance probe for calibration free pulse pressure measurement | |
CN109350124A (en) | The continuous pressure measuring system of minimally-invasive blood vessel based on ultrasonic transducer | |
US20060015032A1 (en) | Non-invasive method for measuring changes in vascular reactivity | |
CN109350126A (en) | The continuous pressure measuring system of bicavate blood vessel based on ultrasonic transducer | |
Nichols | General principles for measuring arterial waves | |
CN109350127A (en) | The continuous pressure measuring system of semi-enclosed blood vessel based on ultrasonic transducer | |
CN109350123A (en) | The continuous pressure measuring system of direct-type blood vessel based on ultrasonic transducer | |
Hanya | Validity of the water hammer formula for determining regional aortic pulse wave velocity: comparison of one-point and two-point (Foot-to-Foot) measurements using a multisensor catheter in human | |
Arathy et al. | Feasibility Study of Arterial Stiffness Monitoring based on Reflected Wave Transit Time using Carotid Acceleration Plethysmogram | |
Weinman | An appraisal of some noninvasive cardiovascular techniques | |
Maldonado‐Moreles et al. | Registration of Intravascular Pressure Curves: Magneto‐Mechanical Evaluation | |
AbuRahma | Overview of noninvasive vascular techniques in peripheral arterial disease | |
CSORDÁS | HOME MONITORING OF PHYSIOLOGICAL SIGNALS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |