CN109289059A - A kind of bactericidal medical ultrasonic couplant and preparation method thereof - Google Patents
A kind of bactericidal medical ultrasonic couplant and preparation method thereof Download PDFInfo
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- CN109289059A CN109289059A CN201811437423.4A CN201811437423A CN109289059A CN 109289059 A CN109289059 A CN 109289059A CN 201811437423 A CN201811437423 A CN 201811437423A CN 109289059 A CN109289059 A CN 109289059A
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- Prior art keywords
- coupling agent
- ultrasonic coupling
- solubilizer
- fungicide
- couplant
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000007822 coupling agent Substances 0.000 claims abstract description 29
- IBGBGRVKPALMCQ-UHFFFAOYSA-N 3,4-dihydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1O IBGBGRVKPALMCQ-UHFFFAOYSA-N 0.000 claims abstract description 22
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229960003500 triclosan Drugs 0.000 claims abstract description 22
- 230000001954 sterilising effect Effects 0.000 claims abstract description 19
- 239000002904 solvent Substances 0.000 claims abstract description 17
- 230000000855 fungicidal effect Effects 0.000 claims abstract description 16
- 239000000417 fungicide Substances 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000080 wetting agent Substances 0.000 claims abstract description 12
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 11
- 229960001631 carbomer Drugs 0.000 claims abstract description 11
- 229960003371 protocatechualdehyde Drugs 0.000 claims abstract description 11
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 18
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 15
- VLDFMKOUUQYFGF-UHFFFAOYSA-N 4-(butoxymethyl)-2-methoxyphenol Chemical compound CCCCOCC1=CC=C(O)C(OC)=C1 VLDFMKOUUQYFGF-UHFFFAOYSA-N 0.000 claims description 13
- 229940078465 vanillyl butyl ether Drugs 0.000 claims description 13
- 239000004359 castor oil Substances 0.000 claims description 10
- 235000019438 castor oil Nutrition 0.000 claims description 10
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 238000007689 inspection Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- -1 polyoxyethylene Polymers 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 10
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
- 238000001514 detection method Methods 0.000 description 13
- 230000000694 effects Effects 0.000 description 8
- 229960001777 castor oil Drugs 0.000 description 7
- 239000000523 sample Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000006399 behavior Effects 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- ZEYHEAKUIGZSGI-UHFFFAOYSA-N 4-methoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C=C1 ZEYHEAKUIGZSGI-UHFFFAOYSA-N 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 206010011409 Cross infection Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 235000004443 Ricinus communis Nutrition 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- JMSVCTWVEWCHDZ-UHFFFAOYSA-N syringic acid Chemical compound COC1=CC(C(O)=O)=CC(OC)=C1O JMSVCTWVEWCHDZ-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000732800 Cymbidium Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 240000000528 Ricinus communis Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 231100000299 mutagenicity Toxicity 0.000 description 1
- 230000007886 mutagenicity Effects 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- YIBXWXOYFGZLRU-UHFFFAOYSA-N syringic aldehyde Natural products CC12CCC(C3(CCC(=O)C(C)(C)C3CC=3)C)C=3C1(C)CCC2C1COC(C)(C)C(O)C(O)C1 YIBXWXOYFGZLRU-UHFFFAOYSA-N 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Radiology & Medical Imaging (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to pharmaceutical sanitary fields, and in particular to a kind of bactericidal medical ultrasonic couplant and preparation method thereof.The ultrasonic coupling agent is mainly made of the raw material of following weight percent: carbomer 0.1~2.0%, wetting agent 2~20%, triethanolamine 0.1~1.0%, fungicide 0.5~2.0%, solubilizer 0.06~1.50%, Tween-80 0.5~1.0% and water 73~96%.The invention is using protocatechualdehyde and triclosan as main sterilization component, has the function of synergy, it is remarkably improved the bactericidal effect of couplant entirety, the solubilizer of addition is remarkably improved the effective content of triclosan in aqueous solution, greatly improves the bactericidal effect of whole couplant.
Description
Technical field
The invention belongs to pharmaceutical sanitary fields, and in particular to a kind of bactericidal medical ultrasonic couplant and preparation method thereof.
Background technique
When ultrasonic wave is incident on the boundary of two kinds of different media, the two impedance difference is bigger, and reflection coefficient is bigger, passes through
The sound that interface enters another medium can be fewer.For medical supersonic, if allowing probe and skin " dry contact ", due to the two it
Between air layer strong reflection effect, the emitted ultrasonic wave of popping one's head in cannot be introduced into human body at all, for that purpose it is necessary in detecting head surface
Certain substance is filled between skin, to drive away air, formation keeps ultrasonic wave smooth and the channel of undistorted propagation, this substance
It is known as medical ultrasonic coupling agent.Since ultrasonic coupling agent is to be coated directly onto skin surface, directly contacted with probe, in addition to not
Skin can be stimulated, is not damaged except probe, it is also necessary to which there is good acoustical behavior, it should be noted that is clinical in order to prevent
Cross-infection, it is also necessary to which there is certain antibacterial, bactericidal property.
Chinese patent application CN105983107A discloses a kind of new medical sterilization ultrasound coupling agent, the couplant
Using magnolol as main Quick disinfection sterilization component, using syringic acid, anisic acid, dipotassium glycyrrhizinate and vanillic aldehyde as collaboration
Action component is compounded by prescription, is improved the efficiency that the detections such as ultrasound are disinfection and sterilizations, is reduced the cell of medical ultrasonic coupling agent
Toxicity, skin irritation and sensitization, the problems such as avoiding the clinically cross-infection of ultrasonic instrument inspection, but invention master
Will be using plant extracts as fungicide active ingredient, stability is low, and sterilizing rate is low, and bactericidal effect is to be improved.
Triclosan is one of Triclosan popular name, has very strong surface-active, is dissolved in organic solvent, to strong acid
Highly basic and heat have high stability, have and extensive kill bacteriostasis and to characteristics such as no skin irritations, be widely used in
It is used as fungicide in the personal care articles such as perfumed soap, mouthwash, cosmetics, is also used for instrument, hand, skin degerming, sterilizing mechanisms
Are as follows: by damage bacterial cell membrane and zymoprotein denaturation is made to reach bactericidal effect.Chinese patent application CN104258427A is public
A kind of bactericidal medical ultrasonic couplant for surface of a wound ultrasonic medical, including carbomer, propylene glycol, glycerine, three second are opened
Hydramine, triclosan, chitosan oligosaccharide, menthol and purified water, the bactericidal medical ultrasonic couplant have the effect of broad-spectrum sterilization, sound
Performance is good, and figure is clear, high resolution；Good biocompatibility, no cytotoxicity, non-sensitization, without mutagenicity do not stimulate skin
The skin surface of a wound；Do not corrode medical ultrasonic probe.But in practical applications, triclosan belongs to according to toxicology acute toxicity grading criteria
In low toxicity, it is specified that additive amount is no more than 0.3%, the more difficult killing pathogenic microorganism within the short time (3min), sterilization is used alone
Effect does not reach requirement.And the intermiscibility of triclosan and aqueous high molecular gel preparation is poor, and antibacterial type product is caused to agglomerate
And muddiness, influence the quality and using effect of product.
In addition, couplant winter using when easily skin can be caused uncomfortable because temperature is low, when in use frequently with heating
Device carries out heating or lasting heat preservation, operates comparatively laborious.
It relaxes when therefore, there is an urgent need to provide a kind of good acoustical behavior, good biocompatibility, rapidly and efficiently can sterilize and use
The suitable medical generation couplant and preparation method thereof felt.
Summary of the invention
The present invention is intended to provide a kind of acoustical behavior is good, good biocompatibility, comfortable when rapidly and efficiently can sterilize and use
Medical generation couplant felt and preparation method thereof.
In order to achieve the above object, the invention adopts the following technical scheme:
A kind of bactericidal medical ultrasonic couplant, the ultrasonic coupling agent is mainly by the raw material system of following weight percent
At: carbomer 0.1~2.5%, wetting agent 2~20%, triethanolamine 0.1~1.0%, fungicide 0.5~2.0%, solubilizer
0.06~1.50%, Tween-80 0.5~1.0% and water 73~96%.
Further, the ultrasonic coupling agent further includes 0.001~0.01% vanillyl butyl ether.
Further, the ultrasonic coupling agent is mainly made of the raw material of following weight percent: carbomer 0.5~
1.5%, wetting agent 5~15%, triethanolamine 0.2~1.0%, fungicide 1.0~2.0%, solubilizer 0.5~1.5%, spit
Temperature -800.5~0.8%, vanillyl butyl ether 0.002~0.008% and water 80~96%.
Further, the ultrasonic coupling agent is made of the raw material of following weight percent: carbomer 0.6%, wetting agent
11%, triethanolamine 0.3%, fungicide 1.2%, solubilizer 1.2%, Tween-80 0.8%, 0.005% and of vanillyl butyl ether
Excess water.
Further, the fungicide is by protocatechualdehyde and triclosan by 1:(0.05~1.5) weight ratio form.
Further, the fungicide is made of protocatechualdehyde and triclosan by the weight ratio of 1:0.2.
Further, the solubilizer by -40 rilanit special of polyoxyethylene ether and castor oil polyoxyethylene ether according to
Weight ratio 1:(0.01~10) composition.
Further, the solubilizer is by -40 rilanit special of polyoxyethylene ether and castor oil polyoxyethylene ether according to weight
Amount is formed than 1:0.5.
Further, the wetting agent is selected from one or both of propylene glycol and glycerine.
In addition, the present invention also provides the preparation methods of the ultrasonic coupling agent described in one kind, comprising the following steps:
S1, it takes the carbomer of corresponding amount to be dissolved in the water of corresponding amount, is swollen 5~7h, obtains solution A；
S2, it takes the solubilizer of corresponding amount and Tween-80 to be mixed evenly, the vanillyl butyl ether of corresponding amount is added, adds
Heat to 70~80 DEG C of 5~15min of stirring, cooling obtains solution B；
S3, the wetting agent of corresponding amount and fungicide is taken to be mixed evenly, addition step S2 acquired solution B, stirring 20~
30min stirs 10~20min, obtains solution C to clarifying and standing defoaming, 10~30 turns/min；
S4, step S3 acquired solution C is added in step S1 acquired solution A, is stirred under vacuum 30~60min, be added dropwise corresponding
The triethanolamine of amount, stirring to transparent gel-form, adjusting pH value of solution is that 6~8,10~30 turns/min stirs 15~25min, matter
Inspection, it is filling, sterilizing to get.
Protocatechualdehyde and triclosan are combined by the present invention, have the function of synergy: on the one hand, the two combination can make
Whole bactericidal effect significantly improves；On the other hand, the two combination can also significantly shorten sterilizing time, reach the effect of quick sterilization
Fruit.This from embodiment 1 as can be seen that the couplant for preparing of the embodiment of the present invention 1~4 in 2min to Escherichia coli, golden yellow
The sterilizing rate of color staphylococcus and Candida albicans is up to 99% or more, be significantly better than the 3min sterilizing rates of standard requirements >=
90%, and couplant bactericidal effect prepared by comparative example 2 (removing triclosan) significantly reduces, and mark is all unable to reach in 3min
Alignment request, comparative example 1 (removing protocatechualdehyde) triclosan content are up to 1.2%, and there are certain toxicity.
In addition, since triclosan is not soluble in water, it is poor with the intermiscibility of aqueous high molecular gel preparation, cause antibacterial type to produce
Product agglomeration and muddiness, influence bactericidal effect, and applicant is found surprisingly that, by -40 rilanit special of polyoxyethylene ether and castor-oil plant
The certain ratio of oily polyoxyethylene ether can significantly improve the bactericidal effect of couplant as solubilizer.By experimental example 1 as it can be seen that
Couplant prepared by comparative example 3 or 4 (removing -40 rilanit special of polyoxyethylene ether and castor oil polyoxyethylene ether respectively) kills
Bacterium significant effect reduces, and standard requirements are all unable to reach in 3min.
In order to improve the use feeling of user, the present invention also added vanillyl butyl ether, can penetrate to the skin
By inner slowly outside fever under surface layer, low irritant, thermal sensation is mild, reduces user in winter arctic weather due to the temperature difference
Bring sense of discomfort makes dermal sensation snugness.This is from experimental example 2 as can be seen that prepared by the embodiment of the present invention 1~4
The clinical feedback comfort level of couplant can significantly improve environment and skin temperature difference bring is ice-cold, excitement 95% or more,
Comfort is brought to user.And embodiment 5 (removing vanillyl butyl ether) sense of discomfort significantly rises to 57%.
The invention has the following advantages that
(1) a kind of bactericidal medical ultrasonic couplant of the present invention, using protocatechualdehyde and triclosan as main sterilization at
Point, have the function of synergy, be remarkably improved the bactericidal effect of couplant entirety, and reaches 99% or more in 2min
Sterilizing rate.
(2) a kind of bactericidal medical ultrasonic couplant of the present invention, with a certain proportion of -40 rilanit special of polyoxyethylene ether
With castor oil polyoxyethylene ether as solubilizer, it is remarkably improved the effective content of triclosan in aqueous solution, is greatly improved whole
The bactericidal effect of body couplant.
(3) a kind of bactericidal medical ultrasonic couplant of the present invention, by adding a certain amount of vanillyl butyl ether, Ke Yixian
It writes and reduces user in winter arctic weather due to temperature difference bring sense of discomfort, make dermal sensation snugness.
Specific embodiment
The specific embodiment of form by the following examples makees further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.
Wherein, agents useful for same of the present invention is common agents, can be purchased from conventional reagent production and sales company.
Examples 1 to 4 bactericidal medical ultrasonic couplant
Component and its weight percent are made 1~4 bactericidal medical ultrasonic couplant of the embodiment of the present invention as shown in Table 1.
1 Examples 1 to 4 bactericidal medical ultrasonic couplant raw material of table and its weight percent
Preparation method:
S1, it takes the carbomer of corresponding amount to be dissolved in the water of corresponding amount, is swollen 6h, obtains solution A；
S2, it takes the solubilizer of corresponding amount and Tween-80 to be mixed evenly, the vanillyl butyl ether of corresponding amount is added, adds
Heat to 75 DEG C of stirring 10min, cooling obtains solution B；
S3, it takes the wetting agent of corresponding amount and fungicide to be mixed evenly, step S2 acquired solution B is added, stir 25min
To clarifying and standing defoaming, 20 turns/min stirs 15min, obtains solution C；
S4, step S3 acquired solution C is added in step S1 acquired solution A, is stirred under vacuum 30~60min, be added dropwise corresponding
The triethanolamine of amount, stirring to transparent gel-form, adjusting pH value of solution is that 7,20 turns/min stirs 20min, and quality inspection is filling, sterilizing,
To obtain the final product.
A kind of ultrasonic coupling agent of embodiment 5
Difference from Example 3 is that embodiment 5 removes vanillyl butyl ether, remaining parameter and preparation method reference
Embodiment 3.
A kind of ultrasonic coupling agent of comparative example 1
Difference from Example 3 is that comparative example 1 removes protocatechualdehyde, increases the weight percent of triclosan extremely
1.2%, remaining parameter and preparation method reference implementation example 3.
A kind of ultrasonic coupling agent of comparative example 2
Difference from Example 3 is that comparative example 2 removes triclosan, increases the weight percent of protocatechualdehyde extremely
1.2%, remaining parameter and preparation method reference implementation example 3.
A kind of ultrasonic coupling agent of comparative example 3
Difference from Example 3 is that comparative example 3 removes -40 rilanit special of polyoxyethylene ether (RH-40), increases
The weight percent of castor oil polyoxyethylene ether (EL-40) is to 1.2%, remaining parameter and preparation method reference implementation example 3.
A kind of ultrasonic coupling agent of comparative example 4
Difference from Example 3 is that comparative example 4 is removed castor oil polyoxyethylene ether (EL-40), increases polyoxyethylene
The weight percent of -40 rilanit special of ether (RH-40) is to 1.2%, remaining parameter and preparation method reference implementation example 3.
1 couplant performance detection of experimental example
Physical property detection, Acoustic detection and safety are carried out to the bactericidal medical ultrasonic couplant of Examples 1 to 4 preparation
Property detection, bactericidal property detection is carried out to ultrasonic coupling agent prepared by Examples 1 to 4 and comparative example 1~4, wherein Acoustic detection
Referring to YY0299-2009, safety detection is referring to GB16886.5-2003 and GB16886.10-2005, physical property detection, sound
Detection and safety detection are learned referring to table 2, bactericidal property is detected referring to table 3.
2 physical property of table, acoustics and safety detection result
3 bactericidal property testing result of table
By table 2 and table 3 it is found that each index of couplant prepared by the embodiment of the present invention 1~3 meets country for couplant
Standard requirements.In bactericidal property detection, couplant prepared by the embodiment of the present invention 1~4 is in 2min to Escherichia coli, gold
The sterilizing rate of staphylococcus aureus and Candida albicans is up to 99% or more, be significantly better than the 3min sterilizing rates of standard requirements >=
90%.And comparative example 1 (removing protocatechualdehyde) can reach standard antiseptic requirement with the triclosan of high concentration in 3min, still
Triclosan concentration is higher, has certain toxicity, and comparative example 2~4 (removes triclosan, -40 hydrogenated castor of polyoxyethylene ether respectively
Oil and castor oil polyoxyethylene ether) prepared by couplant bactericidal effect significantly reduce, be all unable to reach standard in 3min and want
It asks.
2 couplant clinical test of experimental example
The patient for needing B ultrasound to detect to 150 carries out clinical test, is divided into five groups and uses the embodiment of the present invention 1~5 respectively
The couplant of preparation records the use feeling of patient, as a result referring to table 4.
4 couplant clinical test results of table
| Effect | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Comfortably | 98% | 97% | 100% | 100% | 43% |
| It is uncomfortable | 2% | 3% | 0 | 0 | 57% |
As shown in Table 4, the clinical feedback comfort level for the couplant that prepared by the embodiment of the present invention 1~4, can 95% or more
It significantly improves environment and skin temperature difference bring is ice-cold, excitement, bring comfort to user.And embodiment 5 (removes chinese cymbidium
Base butyl ether) sense of discomfort significantly rises to 57%.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of bactericidal medical ultrasonic couplant, which is characterized in that the ultrasonic coupling agent is mainly by following weight percent
Raw material be made: carbomer 0.1~2.0%, wetting agent 2~20%, triethanolamine 0.1~1.0%, fungicide 0.5~
2.0%, solubilizer 0.06~1.50%, Tween-80 0.5~1.0% and water 73~96%.
2. ultrasonic coupling agent according to claim 1, which is characterized in that the ultrasonic coupling agent further includes 0.001~
0.01% vanillyl butyl ether.
3. ultrasonic coupling agent according to claim 2, which is characterized in that the ultrasonic coupling agent is mainly by following weight hundred
The raw material of score is made: carbomer 0.5~1.5%, wetting agent 5~15%, triethanolamine 0.2~1.0%, fungicide 1.0~
2.0%, solubilizer 0.5~1.5%, Tween-80 0.5~0.8%, vanillyl butyl ether 0.002~0.008% and water 80~
96%.
4. ultrasonic coupling agent according to claim 3, which is characterized in that the ultrasonic coupling agent is by following weight percent
Raw material be made: carbomer 0.6%, wetting agent 11%, triethanolamine 0.3%, fungicide 1.2%, solubilizer 1.2%, tween-
800.8%, vanillyl butyl ether 0.005% and excess water.
5. ultrasonic coupling agent according to any one of claims 1 to 4, which is characterized in that the fungicide by protocatechualdehyde and
Triclosan press 1:(0.05~1.5) weight ratio composition.
6. ultrasonic coupling agent according to claim 5, which is characterized in that the fungicide is pressed by protocatechualdehyde and triclosan
1:0.2 weight ratio composition.
7. ultrasonic coupling agent according to any one of claims 1 to 4, which is characterized in that the solubilizer is by polyoxyethylene ether-
40 rilanit specials and castor oil polyoxyethylene ether are according to weight ratio 1:(0.01~10) composition.
8. ultrasonic coupling agent according to claim 7, which is characterized in that the solubilizer is hydrogenated by polyoxyethylene ether -40
Castor oil and castor oil polyoxyethylene ether are formed according to weight ratio 1:0.5.
9. ultrasonic coupling agent according to any one of claims 1 to 4, which is characterized in that the wetting agent be selected from propylene glycol and
One or both of glycerine.
10. according to the preparation method of any ultrasonic coupling agent of claim 2~8, which is characterized in that including following step
It is rapid:
S1, it takes the carbomer of corresponding amount to be dissolved in the water of corresponding amount, is swollen 5~7h, obtains solution A；
S2, it takes the solubilizer of corresponding amount and Tween-80 to be mixed evenly, the vanillyl butyl ether of corresponding amount is added, is heated to
70~80 DEG C of 5~15min of stirring, it is cooling, obtain solution B；
S3, it takes the wetting agent of corresponding amount and fungicide to be mixed evenly, step S2 acquired solution B is added, stir 20~30min
To clarifying and standing defoaming, 10~30 turns/min stirs 10~20min, obtains solution C；
S4, step S3 acquired solution C is added in step S1 acquired solution A, is stirred under vacuum 30~60min, corresponding amount is added dropwise
Triethanolamine, stirring to transparent gel-form, adjusting pH value of solution is that 6~8,10~30 turns/min stirs 15~25min, and quality inspection fills
Dress, sterilizing to get.
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