CN109071551A - 一种三氟甲基取代的吡喃衍生物的制备方法 - Google Patents

一种三氟甲基取代的吡喃衍生物的制备方法 Download PDF

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Publication number
CN109071551A
CN109071551A CN201780023946.1A CN201780023946A CN109071551A CN 109071551 A CN109071551 A CN 109071551A CN 201780023946 A CN201780023946 A CN 201780023946A CN 109071551 A CN109071551 A CN 109071551A
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formula
compound
water
iii
preparation
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CN109071551B (zh
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张晨
王健民
何平
黄龙彬
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Sichuan Haisco Pharmaceutical Co Ltd
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Sichuan Haisco Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

提供一种三氟甲基取代的吡喃衍生物及其中间体的制备方法，即式(I)所示化合物及其中间体的制备方法，该方法反应条件温和，操作简单，反应产率高，产品纯度高，后处理方便，适合于工业化生产

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201780023946.1A 2016-05-25 2017-05-25 一种三氟甲基取代的吡喃衍生物的制备方法 Active CN109071551B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016103572938 2016-05-25
CN201610357293 2016-05-25
PCT/CN2017/085867 WO2017202357A1 (zh) 2016-05-25 2017-05-25 一种三氟甲基取代的吡喃衍生物的制备方法

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CN109071551A true CN109071551A (zh) 2018-12-21
CN109071551B CN109071551B (zh) 2020-12-08

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CN (1) CN109071551B (zh)
WO (1) WO2017202357A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108699068A (zh) * 2016-05-25 2018-10-23 四川海思科制药有限公司 一种三氟甲基取代的吡喃衍生物制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11974985B2 (en) 2018-02-06 2024-05-07 Haisco Pharmaceutical Group Co., Ltd. Composition of aminopyran derivative
CN113200865A (zh) * 2021-03-29 2021-08-03 龙曦宁（上海）医药科技有限公司 一种丁醚脲杂质a、b的合成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101410400A (zh) * 2006-03-28 2009-04-15 默克公司 作为用于糖尿病治疗或者预防的二肽基肽酶-ⅳ抑制剂的氨基四氢吡喃
CN102272136A (zh) * 2008-11-13 2011-12-07 默沙东公司 作为用于糖尿病的治疗或预防的二肽基肽酶-ⅳ抑制剂的氨基四氢吡喃
WO2014018350A1 (en) * 2012-07-23 2014-01-30 Merck Sharp & Dohme Corp. Treating diabetes with dipeptidyl peptidase-iv inhibitors
WO2015192701A1 (zh) * 2014-06-17 2015-12-23 四川海思科制药有限公司 氨基吡喃环衍生物及其组合物和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200806669A (en) * 2006-03-28 2008-02-01 Merck & Co Inc Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101410400A (zh) * 2006-03-28 2009-04-15 默克公司 作为用于糖尿病治疗或者预防的二肽基肽酶-ⅳ抑制剂的氨基四氢吡喃
CN102272136A (zh) * 2008-11-13 2011-12-07 默沙东公司 作为用于糖尿病的治疗或预防的二肽基肽酶-ⅳ抑制剂的氨基四氢吡喃
WO2014018350A1 (en) * 2012-07-23 2014-01-30 Merck Sharp & Dohme Corp. Treating diabetes with dipeptidyl peptidase-iv inhibitors
WO2015192701A1 (zh) * 2014-06-17 2015-12-23 四川海思科制药有限公司 氨基吡喃环衍生物及其组合物和应用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108699068A (zh) * 2016-05-25 2018-10-23 四川海思科制药有限公司 一种三氟甲基取代的吡喃衍生物制备方法

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CN109071551B (zh) 2020-12-08

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