CN108541951A - A kind of symphysis unit composition and its preparation for preventing senile dementia, enhancing memory - Google Patents
A kind of symphysis unit composition and its preparation for preventing senile dementia, enhancing memory Download PDFInfo
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- CN108541951A CN108541951A CN201810104935.2A CN201810104935A CN108541951A CN 108541951 A CN108541951 A CN 108541951A CN 201810104935 A CN201810104935 A CN 201810104935A CN 108541951 A CN108541951 A CN 108541951A
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- Prior art keywords
- senile dementia
- unit composition
- symphysis unit
- probiotics
- enhancing memory
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- 239000000203 mixture Substances 0.000 title claims abstract description 89
- 208000024827 Alzheimer disease Diseases 0.000 title claims abstract description 85
- 206010039966 Senile dementia Diseases 0.000 title claims abstract description 83
- 230000002708 enhancing effect Effects 0.000 title claims abstract description 68
- 239000006041 probiotic Substances 0.000 claims abstract description 70
- 235000018291 probiotics Nutrition 0.000 claims abstract description 70
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 62
- 230000002265 prevention Effects 0.000 claims abstract description 19
- 239000004615 ingredient Substances 0.000 claims description 35
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 20
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 20
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 20
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims description 19
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 claims description 18
- 229940004120 bifidobacterium infantis Drugs 0.000 claims description 18
- 241001608472 Bifidobacterium longum Species 0.000 claims description 17
- 240000001929 Lactobacillus brevis Species 0.000 claims description 16
- 235000013957 Lactobacillus brevis Nutrition 0.000 claims description 16
- 229940009291 bifidobacterium longum Drugs 0.000 claims description 16
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 15
- 229920001202 Inulin Polymers 0.000 claims description 15
- 229920002752 Konjac Polymers 0.000 claims description 15
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims description 15
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 15
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 15
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 15
- 229940029339 inulin Drugs 0.000 claims description 15
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims description 15
- 244000247812 Amorphophallus rivieri Species 0.000 claims description 13
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims description 13
- 150000004676 glycans Chemical class 0.000 claims description 13
- 235000010485 konjac Nutrition 0.000 claims description 13
- 239000000252 konjac Substances 0.000 claims description 13
- 229920001282 polysaccharide Polymers 0.000 claims description 13
- 239000005017 polysaccharide Substances 0.000 claims description 13
- 241000894006 Bacteria Species 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 235000013402 health food Nutrition 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 206010012289 Dementia Diseases 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 244000025254 Cannabis sativa Species 0.000 claims 2
- 241000726221 Gemma Species 0.000 claims 2
- 210000003608 fece Anatomy 0.000 claims 2
- 210000000936 intestine Anatomy 0.000 claims 2
- 241000933856 bacterium 8 Species 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001965 increasing effect Effects 0.000 abstract description 4
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- 235000013305 food Nutrition 0.000 abstract description 2
- 230000000968 intestinal effect Effects 0.000 abstract description 2
- 230000004083 survival effect Effects 0.000 abstract description 2
- 210000002249 digestive system Anatomy 0.000 abstract 1
- 244000063299 Bacillus subtilis Species 0.000 description 18
- 235000014469 Bacillus subtilis Nutrition 0.000 description 18
- 241000194031 Enterococcus faecium Species 0.000 description 18
- 230000000694 effects Effects 0.000 description 10
- -1 malt ketone Chemical class 0.000 description 9
- 230000009286 beneficial effect Effects 0.000 description 7
- 241000186000 Bifidobacterium Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 208000007976 Ketosis Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
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- 230000015556 catabolic process Effects 0.000 description 1
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- 238000006731 degradation reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 1
- 235000019722 synbiotics Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/121—Brevis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/513—Adolescentes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/529—Infantis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/533—Longum
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of prevention senile dementia, the symphysis unit compositions and its preparation of enhancing memory, the prevention senile dementia, the symphysis unit composition for enhancing memory include prebiotics and probiotics, and the weight ratio of the prebiotics and probiotics is 1~10：1~10.The symphysis unit composition of the present invention passes through the rational proportion between probiotics and prebiotics, effectively enhancing effect, prebiotics can be effectively increased the probiotics quantity in composition, extend the term of validity of symphysis unit, not only so that its is efficacy lasting, and promote survival rate of the probiotics in enteron aisle, and prebiotics are while as external source probio food, it can promote the competitive growth of exogenous probiotics and endogenous probiotics simultaneously after entering digestive system, adjust intestinal flora, prevent senile dementia, it can be memory can be enhanced to a certain extent.
Description
Technical field
The invention belongs to microbe additive technical fields, and in particular to a kind of to prevent senile dementia, enhancing memory
Symphysis unit composition and its preparation.
Background technology
Symphysis unit is also known as Synbiotics or symbiosis member, is the composite article of probiotics and prebiotics.Probiotics is one kind to place
Main beneficial active microorganism.And prebiotics refer to a kind of food ingredients that beneficial bacterium can be promoted to grow or substance, be it is a kind of not
Easily by the growth of beneficial bacterium or the active beneficial bacteria product of enhancing beneficial bacterium in human consumption but alternative stimulation enteron aisle.
Now in the art, have the relevant report of symphysis unit, but be formulated mostly unreasonable, be unable to reach preferable work(
Effect, What is more, and good promotion improvement result cannot be played to internal beneficial flora.And existing symphysis unit composition
Specific aim is not strong, and effect is barely satisfactory.
Nowadays with the acceleration of aging of population, China becomes the most country of elderly population in the world.It is this become
Under gesture, disease of old people becomes the emphasis of research, especially senile dementia, and so-called senile dementia generally refers to Alzheimer disease
(Alzheimer's disease,AD).And the patients ' life quality degradation with senile dementia, have a head like a sieve, often
It forgets things, and some things deliberately go note that can also forget, and also can not remember afterwards, has seriously affected work and life, and the day of patient
Daily life ability declines, and wears the clothes, has a meal, stool and urine cannot take care of oneself；Some also has phonism illusion, to oneself and surrounding people with
Come endless pain and worry.
For this purpose, for above insufficient, a kind of product that can be solved the above problems of research and development is very important.
Invention content
The first object of the present invention is to provide a kind of symphysis unit composition for preventing senile dementia, enhancing memory, sheet
The second of invention is designed to provide a kind of preparation for the symphysis unit composition for preventing senile dementia, enhancing memory, the present invention
Third be designed to provide it is a kind of prevention senile dementia, enhance memory symphysis unit composition application.
The first object of the present invention is achieved in that the symphysis tuple prevented senile dementia, enhance memory
It includes prebiotics and probiotics to close object, and the weight ratio of the prebiotics and probiotics is 1~10：1~10.
Preferably, the weight ratio of the prebiotics and probiotics is 3~10：1.
Preferably, the weight ratio of the prebiotics and probiotics is 1：1~7.
Preferably, the prebiotics include the ingredient of following weight percent：Stachyose 20~30%, trehalose 20~
30%, oligoisomaltose 5~15%, oligofructose 5~15%, isomaltoketose 5~15%, inulin 5~15%, konjaku are more
Sugar 5~15%.
Preferably, the prebiotics include the ingredient of following weight percent：Stachyose 23~27%, trehalose 23~
27%, oligoisomaltose 8~12%, oligofructose 8~12%, isomaltoketose 8~12%, inulin 8~12%, konjaku are more
Sugar 8~12%.
Preferably, the probiotics includes the ingredient of following weight percent：Lactobacillus acidophilus 5~15%, short newborn bar
Bacterium 25~35%, bacillus subtilis 0~25%, bifidobacterium infantis 5~20%, bifidobacterium adolescentis 5~15%, long bifid
Bacillus 5~15%, enterococcus faecium 0~15%.
Preferably, the probiotics includes the ingredient of following weight percent：Lactobacillus acidophilus 5~15%, short newborn bar
Bacterium 25~35%, bacillus subtilis 15~25%, bifidobacterium infantis 5~15%, bifidobacterium adolescentis 5~15%, length are double
Discrimination bacillus 5~15%, enterococcus faecium 5~15%.
Preferably, the probiotics includes the ingredient of following weight percent：Lactobacillus acidophilus 8~12%, short newborn bar
Bacterium 28~32%, bacillus subtilis 18~22%, bifidobacterium infantis 8~12%, bifidobacterium adolescentis 8~12%, length are double
Discrimination bacillus 8~12%, enterococcus faecium 8~12%.
The second object of the present invention is achieved in that the preparation is in the prevention senile dementia, enhancing note
Recall and pharmaceutically acceptable auxiliary material is added in the symphysis unit composition of power powder, tablet, granule, capsule, liquid is made
Preparation.
The third object of the present invention is achieved in that the symphysis tuple prevented senile dementia, enhance memory
Close application of the object in the drug or health food for preparing prevention/auxiliary treatment senile dementia, failure of memory.
The instructions of taking of the symphysis unit composition of the present invention for preventing senile dementia, enhancing memory, feature exist
In the instructions of taking of the described symphysis unit composition for preventing senile dementia, enhancing memory be 1~2 time on the one, every time 10~
20g。
The instructions of taking is oral.
The entitled Lactobacillus acidophilus of Latin of the lactobacillus acidophilus.
The entitled Lactobacillus breris of Latin of the Lactobacillus brevis.
The entitled Bacillus subtilis of Latin of the bacillus subtilis.
The entitled Bifidobacterium infantisy of Latin of the bifidobacterium infantis.
The entitled B.adolescebntils of Latin of the bifidobacterium adolescentis.
The entitled B.longum of Latin of the bifidobacterium longum.
The entitled E.faecium of Latin of the enterococcus faecium.
Compared with prior art, beneficial effects of the present invention：
1, symphysis unit composition of the invention effectively enhances effect by the rational proportion between probiotics and prebiotics, prebiotic
Member can be effectively increased the probiotics quantity in composition, extend the term of validity of symphysis unit, not only so that its is efficacy lasting, but also
Promote survival rate of the probiotics in enteron aisle, and prebiotics can digest while as external source probio food entering
The competitive growth for promoting exogenous probiotics and endogenous probiotics after system simultaneously, adjusts intestinal flora, prevents old
Dementia, can be can enhance memory to a certain extent.
2, combination and the ingredient appropriate that symphysis unit composition of the present invention passes through the selection probiotics and prebiotics of science
Proportioning is so that the symphysis unit composition clear efficacy is notable, and ingredient is safe and effective, and material matching is reasonable.
3, the present invention obtains the material composition proportioning of science through a large number of experiments, is targetedly selected according to application crowd
The optimum composition method for selecting probiotics and prebiotics, by scientific and effective proportioning so that symphysis unit composition performance is maximum
Effect so that the present invention can not only effectively realize its effect, and selected prebiotics can the benefit arranged in pairs or groups of effective stimulus
Raw bacterium proliferation, reasonable composition.
4, instructions of taking dosage of the invention is reasonable, and obvious effect effectively prevents existing probiotics preparation dosage not
It to no effect or takes after being taken caused by clear and is excessively possible to the ill effect brought.
5, symphysis unit composition of the invention can both play the physiological bacterial activity of probiotics, and cooperation prebiotics are again optional
The quantity for quickly increasing to selecting property probiotics, makes that probiotic action speed is fast and effect is lasting, to play simultaneously probiotics and
The physiological function of prebiotics；The present invention also has the advantages that significant effect, quick, safe.
Specific implementation mode
With reference to embodiment, the present invention is further illustrated, but is not limited in any way to the present invention,
Based on present invention teach that made by it is any transform or replace, all belong to the scope of protection of the present invention.
Embodiment 1
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, the prebiotics
Weight ratio with probiotics is 1：10.
Embodiment 2
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, the prebiotics
Weight ratio with probiotics is 10：1.
Embodiment 3
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, the prebiotics
Weight ratio with probiotics is 9：2.
Embodiment 4
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, the prebiotics
Weight ratio with probiotics is 2：9.
Embodiment 5
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, the prebiotics
Weight ratio with probiotics is 7.5：3.
Embodiment 6
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, the prebiotics
Weight ratio with probiotics is 3：7.5.
Embodiment 7
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, the prebiotics
Weight ratio with probiotics is 5：4.
Embodiment 8
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, the prebiotics
Weight ratio with probiotics is 3：1.
Embodiment 9
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, the prebiotics
Weight ratio with probiotics is 1：7.
Embodiment 10
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, the prebiotics
Weight ratio with probiotics is 1：1.
Embodiment 11
The symphysis unit composition for preventing senile dementia as described in Example 1, enhancing memory, the prebiotics include following
The ingredient of weight percent：Stachyose 20%, trehalose 20%, oligoisomaltose 5%, oligofructose 10%, different malt ketone
Sugar 15%, inulin 15%, konjac polysaccharide 15%.
Embodiment 12
The symphysis unit composition for preventing senile dementia as described in Example 2, enhancing memory, the prebiotics include following
The ingredient of weight percent：Stachyose 30%, trehalose 30%, oligoisomaltose 15%, oligofructose 10%, different malt ketone
Sugar 5%, inulin 5%, konjac polysaccharide 5%.
Embodiment 13
The symphysis unit composition for preventing senile dementia as described in Example 3, enhancing memory, the prebiotics include following
The ingredient of weight percent：Stachyose 25%, trehalose 25%, oligoisomaltose 10%, oligofructose 10%, different malt ketone
Sugar 10%, inulin 10%, konjac polysaccharide 10%.
Embodiment 14
The symphysis unit composition for preventing senile dementia as described in Example 4, enhancing memory, the prebiotics include following
The ingredient of weight percent：Stachyose 23%, trehalose 23%, oligoisomaltose 8%, oligofructose 10%, different malt ketone
Sugar 12%, inulin 12%, konjac polysaccharide 12%.
Embodiment 15
The symphysis unit composition for preventing senile dementia as described in Example 5, enhancing memory, the prebiotics include following
The ingredient of weight percent：Stachyose 27%, trehalose 27%, oligoisomaltose 12%, oligofructose 10%, different malt ketone
Sugar 8%, inulin 8%, konjac polysaccharide 8%.
Embodiment 16
The symphysis unit composition for preventing senile dementia as described in Example 6, enhancing memory, the prebiotics include following
The ingredient of weight percent：Stachyose 21%, trehalose 21%, oligoisomaltose 12%, oligofructose 5%, different malt ketone
Sugar 13%, inulin 14%, konjac polysaccharide 14%.
Embodiment 17
The symphysis unit composition for preventing senile dementia as described in Example 7, enhancing memory, the prebiotics include following
The ingredient of weight percent：Stachyose 22%, trehalose 22%, oligoisomaltose 7%, oligofructose 15%, different malt ketone
Sugar 8%, inulin 13%, konjac polysaccharide 13%.
Embodiment 18
The symphysis unit composition for preventing senile dementia as described in Example 8, enhancing memory, the prebiotics include following
The ingredient of weight percent：Stachyose 23%, trehalose 23%, oligoisomaltose 9%, oligofructose 9%, isomaltoketose
12%, inulin 12%, konjac polysaccharide 12%.
Embodiment 19
The symphysis unit composition for preventing senile dementia as described in Example 9, enhancing memory, the prebiotics include following
The ingredient of weight percent：Stachyose 24%, trehalose 24%, oligoisomaltose 7%, oligofructose 12%, different malt ketone
Sugar 11%, inulin 11%, konjac polysaccharide 11%.
Embodiment 20
As described in Example 10 prevent senile dementia, enhance memory symphysis unit composition, the prebiotics include with
The ingredient of lower weight percent：Stachyose 26%, trehalose 26%, oligoisomaltose 11%, oligofructose 10%, different malt
Ketose 9%, inulin 9%, konjac polysaccharide 9%.
Embodiment 21
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, wherein described
Prebiotics include the ingredient of following weight percent：Stachyose 27%, trehalose 27%, oligoisomaltose 14%, oligomeric fruit
Sugar 11%, isomaltoketose 7%, inulin 7%, konjac polysaccharide 7%.
Embodiment 22
The symphysis unit composition for preventing senile dementia as described in Example 1, enhancing memory, the probiotics includes following
The ingredient of weight percent：Lactobacillus acidophilus 5%, Lactobacillus brevis 25%, bacillus subtilis 15%, bifidobacterium infantis
10%, bifidobacterium adolescentis 15%, bifidobacterium longum 15%, enterococcus faecium 15%.
Embodiment 23
The symphysis unit composition for preventing senile dementia as described in Example 2, enhancing memory, the probiotics includes following
The ingredient of weight percent：Lactobacillus acidophilus 15%, Lactobacillus brevis 35%, bacillus subtilis 25%, bifidobacterium infantis
10%, bifidobacterium adolescentis 5%, bifidobacterium longum 5%, enterococcus faecium 5%.
Embodiment 24
The symphysis unit composition for preventing senile dementia as described in Example 3, enhancing memory, the probiotics includes following
The ingredient of weight percent：Lactobacillus acidophilus 10%, Lactobacillus brevis 30%, bacillus subtilis 20%, bifidobacterium infantis
10%, bifidobacterium adolescentis 10%, bifidobacterium longum 10%, enterococcus faecium 10%.
Embodiment 25
The symphysis unit composition for preventing senile dementia as described in Example 4, enhancing memory, the probiotics includes following
The ingredient of weight percent：Lactobacillus acidophilus 8%, Lactobacillus brevis 28%, bacillus subtilis 18%, bifidobacterium infantis
10%, bifidobacterium adolescentis 12%, bifidobacterium longum 12%, enterococcus faecium 12%.
Embodiment 26
The symphysis unit composition for preventing senile dementia as described in Example 5, enhancing memory, the probiotics includes following
The ingredient of weight percent：Lactobacillus acidophilus 12%, Lactobacillus brevis 32%, bacillus subtilis 22%, bifidobacterium infantis
10%, bifidobacterium adolescentis 8%, bifidobacterium longum 8%, enterococcus faecium 8%.
Embodiment 27
The symphysis unit composition for preventing senile dementia as described in Example 6, enhancing memory, the probiotics includes following
The ingredient of weight percent：Lactobacillus acidophilus 6%, Lactobacillus brevis 31%, bacillus subtilis 16%, bifidobacterium infantis 5%,
Bifidobacterium adolescentis 14%, bifidobacterium longum 14%, enterococcus faecium 14%.
Embodiment 28
The symphysis unit composition for preventing senile dementia as described in Example 7, enhancing memory, the probiotics includes following
The ingredient of weight percent：Lactobacillus acidophilus 11%, Lactobacillus brevis 26%, bacillus subtilis 21%, bifidobacterium infantis
15%, bifidobacterium adolescentis 9%, bifidobacterium longum 9%, enterococcus faecium 9%.
Embodiment 29
The symphysis unit composition for preventing senile dementia as described in Example 8, enhancing memory, the probiotics includes following
The ingredient of weight percent：Lactobacillus acidophilus 7%, Lactobacillus brevis 27%, bacillus subtilis 17%, bifidobacterium infantis
10%, bifidobacterium adolescentis 13%, bifidobacterium longum 13%, enterococcus faecium 13%.
Embodiment 30
The symphysis unit composition for preventing senile dementia as described in Example 9, enhancing memory, the probiotics includes following
The ingredient of weight percent：Lactobacillus acidophilus 9%, Lactobacillus brevis 28%, bacillus subtilis 20%, bifidobacterium infantis 8%,
Bifidobacterium adolescentis 12%, bifidobacterium longum 12%, enterococcus faecium 11%.
Embodiment 31
As described in Example 10 prevent senile dementia, enhance memory symphysis unit composition, the probiotics include with
The ingredient of lower weight percent：Lactobacillus acidophilus 9%, Lactobacillus brevis 29%, bacillus subtilis 19%, bifidobacterium infantis
12%, bifidobacterium adolescentis 11%, bifidobacterium longum 11%, enterococcus faecium 9%.
Embodiment 32
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, wherein described
Probiotics includes the ingredient of following weight percent：Lactobacillus acidophilus 11%, Lactobacillus brevis 31%, bacillus subtilis 21%,
Bifidobacterium infantis 11%, bifidobacterium adolescentis 8%, bifidobacterium longum 11%, enterococcus faecium 7%.
Embodiment 33
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, wherein described
Probiotics includes the ingredient of following weight percent：Lactobacillus acidophilus 13%, Lactobacillus brevis 33%, bacillus subtilis 23%,
Bifidobacterium infantis 10%, bifidobacterium adolescentis 7%, bifidobacterium longum 7%, enterococcus faecium 7%.
Embodiment 34
A kind of symphysis unit composition for preventing senile dementia, enhancing memory, including prebiotics and probiotics, wherein described
Probiotics includes the ingredient of following weight percent：Lactobacillus acidophilus 15%, Lactobacillus brevis 35%, bacillus subtilis 0%, baby
Youngster Bifidobacterium 20%, bifidobacterium adolescentis 15%, bifidobacterium longum 15%, enterococcus faecium 0%.
Embodiment 35
A kind of preparation for the symphysis unit composition for preventing senile dementia, enhancing memory, the preparation is in the prevention
Senile dementia enhances and in the symphysis unit composition of memory pharmaceutically acceptable auxiliary material is added powder is made.
The symphysis unit composition for preventing senile dementia, enhancing memory is silly in preparation prevention/auxiliary treatment old age
Application in slow-witted drug.
Embodiment 36
A kind of preparation for the symphysis unit composition for preventing senile dementia, enhancing memory, the preparation is in the prevention
Senile dementia enhances and in the symphysis unit composition of memory pharmaceutically acceptable auxiliary material is added tablet is made.
The symphysis unit composition for preventing senile dementia, enhancing memory is silly in preparation prevention/auxiliary treatment old age
Application in slow-witted health food.
Embodiment 37
A kind of preparation for the symphysis unit composition for preventing senile dementia, enhancing memory, the preparation is in the prevention
Senile dementia enhances and in the symphysis unit composition of memory pharmaceutically acceptable auxiliary material is added granule is made.
The symphysis unit composition for preventing senile dementia, enhancing memory is preparing prevention/auxiliary treatment memory
Application in the drug of decline.
Embodiment 38
A kind of preparation for the symphysis unit composition for preventing senile dementia, enhancing memory, the preparation is in the prevention
Senile dementia enhances and in the symphysis unit composition of memory pharmaceutically acceptable auxiliary material is added capsule is made.
The symphysis unit composition for preventing senile dementia, enhancing memory is preparing prevention/auxiliary treatment memory
Application in the health food of decline.
Embodiment 39
A kind of preparation for the symphysis unit composition for preventing senile dementia, enhancing memory, the preparation is in the prevention
Senile dementia enhances and in the symphysis unit composition of memory pharmaceutically acceptable auxiliary material is added liquid preparation is made.
The symphysis unit composition for preventing senile dementia, enhancing memory is silly in preparation prevention/auxiliary treatment old age
Application in slow-witted drug or health food.
Embodiment 40
Experimental example：Gold certain, female, Yunnan people from Nujiang 75 years old, there is a familial inheritance medical history, and wherein mother suffered from senile dementia, gold certain
The uninterrupted symphysis unit composition capsule taken the present invention and prepared from 60 years old, once a day, trouble is not detected in each 20g so far
Disease.
Embodiment 41
Experimental example：Wu, man, Kunming, Yunnan people, 74 years old, failure of memory recognized people and has any problem, and was often in lost nearby, no
Interruption takes symphysis unit composition tablet prepared by the present invention, and two times a day, each 10g, after taking one month, memory has
It significantly improves, normally can recognize people and recognize road.
Embodiment 42
Experimental example：Hole, man, Luquan, Yunnan Province people, 80 years old, old dementia patients used the present invention in normal treatment cycle
Symphysis unit carry out auxiliary treatment, specially uninterruptedly take the symphysis unit composition granule for preparing of the present invention, two times a day,
Each 15g after taking, is compared with the therapeutic effect of the symphysis unit of the present invention is not assisted, is not only obtained the case where senile dementia
To significantly improving, and therapeutic effect is also significantly increased than before.
Claims (10)
1. a kind of symphysis unit composition for preventing senile dementia, enhancing memory, it is characterised in that the prevention senile dementia,
The symphysis unit composition of enhancing memory includes prebiotics and probiotics, and the weight ratio of the prebiotics and probiotics is 1~
10：1~10.
2. the symphysis unit composition according to claim 1 for preventing senile dementia, enhancing memory, it is characterised in that described
Prebiotics and probiotics weight ratio be 3~10：1.
3. the symphysis unit composition according to claim 1 for preventing senile dementia, enhancing memory, it is characterised in that described
Prebiotics and probiotics weight ratio be 1：1~7.
4. the symphysis unit composition according to claim 1 for preventing senile dementia, enhancing memory, it is characterised in that described
Prebiotics include following weight percent ingredient：Stachyose 20~30%, trehalose 20~30%, oligoisomaltose 5
~15%, oligofructose 5~15%, isomaltoketose 5~15%, inulin 5~15%, konjac polysaccharide 5~15%.
5. the symphysis unit composition according to claim 1 for preventing senile dementia, enhancing memory, it is characterised in that described
Prebiotics include following weight percent ingredient：Stachyose 23~27%, trehalose 23~27%, oligoisomaltose 8
~12%, oligofructose 8~12%, isomaltoketose 8~12%, inulin 8~12%, konjac polysaccharide 8~12%.
6. the symphysis unit composition according to claim 1 for preventing senile dementia, enhancing memory, it is characterised in that described
Probiotics include following weight percent ingredient：Lactobacillus acidophilus 5~15%, Lactobacillus brevis 25~35%, withered grass gemma
Bacillus 0~25%, bifidobacterium infantis 5~20%, bifidobacterium adolescentis 5~15%, bifidobacterium longum 5~15%, dung intestines ball
Bacterium 0~15%.
7. the symphysis unit composition according to claim 1 for preventing senile dementia, enhancing memory, it is characterised in that described
Probiotics include following weight percent ingredient：Lactobacillus acidophilus 8~12%, Lactobacillus brevis 28~32%, withered grass gemma
Bacillus 18~22%, bifidobacterium infantis 8~12%, bifidobacterium adolescentis 8~12%, bifidobacterium longum 8~12%, dung intestines ball
Bacterium 8~12%.
8. a kind of system according to any symphysis unit composition for preventing senile dementia, enhancing memory of claim 1~7
Agent, it is characterised in that the preparation be the preventions senile dementia, enhancing memory symphysis unit composition in be added
Pharmaceutically powder, tablet, granule, capsule, liquid preparation is made in acceptable auxiliary material.
9. a kind of symphysis unit composition according to claim 1~7 any preventions senile dementia, enhancing memory is answered
With, it is characterised in that the symphysis unit composition for preventing senile dementia, enhancing memory is old in preparation prevention/auxiliary treatment
Dementia, the drug of failure of memory or the application in health food.
10. a kind of according to any symphysis unit composition for preventing senile dementia, enhancing memory of claim 1~7
Instructions of taking, it is characterised in that the instructions of taking of the symphysis unit composition for preventing senile dementia, enhancing memory is one
Day 1~2 time, 10~20g every time.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111096455A (en) * | 2020-01-15 | 2020-05-05 | 浙江科技学院 | Total nutrient formula food for resisting senile dementia |
| CN111202754A (en) * | 2019-03-11 | 2020-05-29 | 江苏佰澳达生物科技有限公司 | Probiotic composition for preventing and improving senile dementia and application thereof |
| WO2021015288A1 (en) * | 2019-07-24 | 2021-01-28 | 雪印メグミルク株式会社 | Composition for maintenance and/or improvement of memory/learning ability, and food, medicine and feed each containing said composition |
| CN114177265A (en) * | 2021-12-30 | 2022-03-15 | 中国大冢制药有限公司 | Composition for preventing and/or treating Alzheimer's disease and preparation method and application thereof |
| CN115998780A (en) * | 2023-02-28 | 2023-04-25 | 南京中科药业有限公司 | Probiotic composition capable of improving cognitive level of Alzheimer disease and application thereof |
| EP4011448A4 (en) * | 2019-08-08 | 2023-08-30 | Morinaga Milk Industry Co., Ltd. | Composition for babies and infants for improving memory ability in childhood |
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2018
- 2018-02-02 CN CN201810104935.2A patent/CN108541951A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111202754A (en) * | 2019-03-11 | 2020-05-29 | 江苏佰澳达生物科技有限公司 | Probiotic composition for preventing and improving senile dementia and application thereof |
| WO2021015288A1 (en) * | 2019-07-24 | 2021-01-28 | 雪印メグミルク株式会社 | Composition for maintenance and/or improvement of memory/learning ability, and food, medicine and feed each containing said composition |
| CN114786504A (en) * | 2019-07-24 | 2022-07-22 | 雪印惠乳业株式会社 | Composition for maintaining and/or improving memory/learning ability and food, medicine and feed containing the same |
| EP4011448A4 (en) * | 2019-08-08 | 2023-08-30 | Morinaga Milk Industry Co., Ltd. | Composition for babies and infants for improving memory ability in childhood |
| CN111096455A (en) * | 2020-01-15 | 2020-05-05 | 浙江科技学院 | Total nutrient formula food for resisting senile dementia |
| CN114177265A (en) * | 2021-12-30 | 2022-03-15 | 中国大冢制药有限公司 | Composition for preventing and/or treating Alzheimer's disease and preparation method and application thereof |
| CN115998780A (en) * | 2023-02-28 | 2023-04-25 | 南京中科药业有限公司 | Probiotic composition capable of improving cognitive level of Alzheimer disease and application thereof |
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Application publication date: 20180918 |