CN108186541A - Multi-efficiency type mouthwash and preparation method thereof - Google Patents
Multi-efficiency type mouthwash and preparation method thereof Download PDFInfo
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- CN108186541A CN108186541A CN201810224269.6A CN201810224269A CN108186541A CN 108186541 A CN108186541 A CN 108186541A CN 201810224269 A CN201810224269 A CN 201810224269A CN 108186541 A CN108186541 A CN 108186541A
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- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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Abstract
The present invention discloses a kind of multi-efficiency type mouthwash, includes the composition of following parts by weight：2.8 3.6 parts by weight of solubilizer, 23 parts by weight of glycerine, 0.8 1.1 parts by weight of effect additive, 0.3 0.4 parts by weight of preservative, 18.4 20.3 parts by weight of taste-modifier, surplus is water.The mouthwash preparation method of the present invention is simple, and mouthfeel is careful, pure and fresh pleasant, does not stimulate mildly, has anti-inflammatory antiallergic, Antipyretic, hemostasis, protects mucous membrane of mouth well, safeguard oral health.
Description
Technical field
The present invention relates to oral health technical fields, more particularly to multi-efficiency type mouthwash and preparation method thereof.
Background technology
The 4th National Health epidemiological survey in China the results show that by for many years oral health publicize and education,
By the way of brushing teeth and using toothpaste with fluoride oneself through obtaining the extensive approval of the whole society.Compared with before 10 years, resident is good in oral cavity
Health literacy level and healthy behavior situation have different degrees of improvement.Wherein, resident's oral health knowledge awareness is
60.1%, 84.9% people holds positive attitude to oral health.The rate of brushing teeth is respectively twice daily by 5 years old and 12 years old children
24.1%th, 31.9%, toothpaste with fluoride utilization rate is respectively 42.1%, 55%, because prevention mouth disease and consulting check what is gone to a doctor
Ratio is respectively 40%, 43.2%.Adult brushes teeth rate as 36.1% twice daily, and toothpaste with fluoride utilization rate is 61.0%.Each year
The rate of brushing teeth is above male to age group women twice daily, and city is higher than rural area.But the secondary investigation result is also shown, China's multiple years
Age crowd's caries prevalence rate of section is in the high level of comparison.In China, investigation display, dental caries caries incidence is within 12 years old
34.5%, than 10 years before rise 7.8 percentage points.5 years old Primary Caries suffer from rate for 70.9%, than 10 years before rise 5.8
Percentage point.Rural area is higher than city.Children suffer from dental caries situation and rising situation have been presented.It is counted according to Stomatology Clinic, due to dental caries
And its complication and clients, the 60% of outpatient's sum is accounted for, the tooth pulled out due to these reasons accounts for the one of extraction sum
Half.Although this shows that most people have been able to accomplish to brush teeth daily, the generation of dental caries could not be still controlled.
With the development of economy, improvement of living standard, people also greatly enhance the consciousness of oral health；Oral health
Just have historically been a concern.With the promotion and variation of the market demand and consumption idea, the own warp of oral care product pattern
The group for upgrading to the products such as toothpaste, dental floss, tooth patch, mouthwash, electric toothbrush gradually by initial toothpaste " dominance " makees
War, consumption purpose also develop into shield tooth U.S. tooth, cleaning oral cavity by single cleaning tooth.
Traditional mouthwash is mainly formed as essence, surfactant, fluoride, strontium chloride, alcohol and water etc., can clean mouth
Chamber, pre- anti-caries and periodontitis etc..Mouthfeel is excessively cool excessively peppery in existing mouthrinse product, and excitement is set for the foreigner strongly
Meter is not suitable for Chinese's use.Due to alcohol to some it is not soluble in water the effect of ingredient dissolubility it is good, height of enhancing the transparency is gargled
Alcohol is usually added in saliva, but alcohol can lead to xerostomia, destroy the mucus protective layer for keeping oral cavity moistening, addition is excessive
It there may also be tingling sensation.But without using alcohol, emulsifying solubiliser must just be selected to promote the dissolving of menthol, essence etc., really
Protect transparency；In the selection of emulsifying solubiliser, needed using >=0.8% or polysorbate using Cremophor RH40-
20 need the requirement that can be only achieved transparency using >=0.9%, but it can bring faint chemical reagent taste into, cause not
It is suitable；So as to most directly be also most important mouthfeel index in the water quality evaluation that influences to gargle.In terms of sweet taste, the saccharin sodium of addition can cause
It has a poor flavour, the ingredient that commercial product uses is mostly saccharin sodium and sorbierite, and advantage is that price is cheap, and shortcoming is that slightly band is bitter
Taste, the addition of part saccharin sodium excessively also result in flavor variation.
Invention content
The purpose of the present invention is to provide a kind of mouthwashes of multi-efficiency type, have anti-inflammatory antiallergic, Antipyretic, hemostasis
Mucous membrane is protected, is not stimulated mildly, mouthfeel is careful, pure and fresh pleasant.
It is another object of the present invention to provide a kind of preparation method of the mouthwash of multi-efficiency type, using a variety of multiple
With technique, solubility and mouthfeel are improved, simple for process, production efficiency is high, and energy consumption is small, is suitable for industrialized production.
The present invention provides multi-efficiency type mouthwash, includes the composition of following parts by weight：Solubilizer 2.8-3.6 parts by weight,
Glycerine 2-3 parts by weight, effect additive 0.8-1.1 parts by weight, preservative 0.3-0.4 parts by weight, taste-modifier 18.4-20.3
Parts by weight, surplus are water.
The effect of described additive for stephania tetrandra extract, Notogineng Extract, Honegsukle flower P.E, tranexamic acid, the root bark of tree peony
Phenol, propolis extract, western arsenic oronain and the two or more combinations of dipotassium glycyrrhizinate.
Preferably, effect additive for stephania tetrandra extract, Notogineng Extract, Honegsukle flower P.E, tranexamic acid,
Two or more in Paeonol and western arsenic oronain are used in compounding.
The preservative is one or more of sodium benzoate, methyl hydroxybenzoate and ethylparaben.
Preferably, 3 kinds of the preservative sodium benzoate, methyl hydroxybenzoate and ethylparaben are used in compounding, ratio 4:
1:1。
The taste-modifier is saccharin sodium, sorbierite, tri-chloro galactose type sugar, xylitol, menthol, menthyl lactate, chlorine
Change one or more of sodium and essence；Wherein sorbierite, saccharin sodium, tri-chloro galactose type sugar, xylitol are sweetener；Peppermint
Alcohol is coolant agent with menthyl lactate, and usage amount is 0.1-0.2 parts by weight.
Preferably, the sweetener is used in compounding using sorbierite, tri-chloro galactose type sugar, xylitol, ratio 20:0.05:
0.1。
The solubilizer is one kind or more in ethyl alcohol, Cremophor RH40, polysorbate -20 and propylene glycol
Kind.
Preferably, the solubilizer is -20 ratio 1 of Cremophor RH40 and polysorbate:1 is used in compounding.
The preparation method of the multi-efficiency type mouthwash, step are：First water to be insoluble in the effect of additive,
After methyl hydroxybenzoate is dissolved completely in essence with ethylparaben, add in Cremophor RH40 and polysorbate -20
In stir evenly, add in propylene glycol in be pre-mixed；Water-soluble effect additive is dissolved completely in water with sweetener, sodium benzoate
In, sorbierite and glycerine are added in, after stirring evenly, the good premix of mixed dissolution is poured into, stirring 20-30min is opened and mixes
It closes uniform；Then pH value control is carried out, is aged 24 hours；To enhance the transparency, the machines such as the fiber brought into manufacturing process are dispelled
Tool impurity, discharging process need to add in filter device, be filtered again before filling.
The root of fangji, also known as Fourstamen Stephania Root, Stephania tetrandra are one of traditional conventional Chinese medicines, containing there are many alkaloid, main actives
For tetrandrine and fangchinoline.Tetrandrine has broad spectrum antiphlogistic effect, equal to the Acute and chronic inflammation at each position of whole body
There can be inhibiting effect.It is primarily present in the root of menispermaceous plants Fourstamen Stephania Root, for Bisbenzylisoquinolinderivative derivative, colourless needles
It crystallizes (ether), is practically insoluble in water, petroleum ether is dissolved in ether and certain organic solvents.The experiment of early stage is proved Fourstamen Stephania Root
Alkali has decompression, expansion coronary artery, anticancer, antibacterial action.Nearest research has shown that tetrandrine is calcium channel blocker.Open letter refining
The anti-heart of tetrandrine is described in (the miscellaneous special will of Chinese Hospitals pharmacy, 01 phase in 1988) in " pharmacology of tetrandrine and clinic "
Myocardial ischemia, anti-arrhythmia, decompression, anti-allergic effects and its mechanism of action, clinical practice.Present is clinically mainly used for
Advanced low-grade hypertension, rheumatalgia, arthralgia, neuralgia etc. are additionally operable to each phase silicosis of pure and anthracosilicosis.Applied to gargling
In water, mechanism of action is mainly：Inhibit histamine release；Inhibit phosphatase A2 and arachidonic acid；Inhibit Cycloxygenase with before
Row parathyrine；Inhibit interleukin and tumor necrosis factor.The anti-inflammatory antiallergic effect of stephania tetrandra extract has been subjected to multiple clinical test
It proves.In addition tetrandrine also has stronger anti-Staphylococcus aureus, Candida albicans activity, mass concentration 2gL-1, antibacterial circle diameter 10-22mm.The effect for selecting stephania tetrandra extract that can make mouthwash that there is anti-inflammatory antiallergic.Additive amount is
0.05%-0.2%.
Stephania tetrandra extract applies advanced supercritical carbon dioxide extraction method and is made, this method with it is nontoxic, be easy to get, honest and clean
The CO of valency2It extracts Chinese herbal medicine functional component in the supercritical state for fluid, there are good, simple for process, the suitable rule of extraction effect
Modelling produce, it is with short production cycle the features such as.Using the vegetable oil not only purity height, but also be not present of supercritical carbon dioxide extraction
The problem of organic solvent residual, further ensure plant extracts the effect of property and safety.
Paeonol, Paeonol are a kind of Chinese medicines that extract comes out from the root skin of the national flower peony of China.Extraction
From the dry root skin of ranunculaceae peony.Paeonol has the function of analgesia, anti-inflammatory, antipyretic and inhibition allergy.To pressure
The physically or chemically pain caused by factor such as tail, acetic acid has apparent analgesic activity.To by carrageenan, egg white, formaldehyde,
Inflammatory reaction caused by histamine, serotonin, bradykinin, dimethylbenzene and endotoxin etc., significantly inhibits.Therefore it is right
The pain that acidic environment in oral cavity generates has good remission effect.According to its solubility and efficacy requirements dosage, additive amount
For 0.01%-0.02%.And be found in the process in the on probation of final products, the compounding of stephania tetrandra extract and Paeonol makes
With mutually promoting in antiallergic effect, its curative effect made to be significantly increased.
Tranexamic acid, tranexamic acid belong to one kind in fibrinolysis depressant, pass through reversible fibrinolysin
Lysine-binding site on original molecule causes plasminogen that cannot be changed into fibrinolysin, so as to effectively inhibit plasmin
Solution generates anastalsis, it is early there are some researches prove, tranexamic acid can effectively alleviate bleeding gums situation, meanwhile, tranexamic acid is also
With mucous membrane of mouth effect is repaired, this can prove that the skin barrier function reparation that it is played is imitated by testing percutaneous water loss amount
Fruit.Additive amount is 0.03%-0.05%.
Notogineng Extract and Honegsukle flower P.E, root of the Notogineng Extract source for panax araliaceae plant, main component
For arasaponin, there is promoting blood circulation, hemostasis, additive amount 0.3%-0.5%.And Honegsukle flower P.E, it is to extract from
Honeysuckle flower, main ingredient are chlorogenic acid, and clinical application is very extensive, and primary efficacy is clearing heat and detoxicating, additive amount
For 0.3%-0.5%.
The beneficial effects of the invention are as follows：
1st, mouthwash preparation method of the invention is simple, and mouthfeel is careful, pure and fresh pleasant, does not stimulate mildly, resists with anti-inflammatory
Quick, Antipyretic, hemostasis, protect mucous membrane of mouth well, safeguard oral health.
2nd, the method that Cremophor RH40 has been selected to be used in compounding with polysorbate -20, dosage can reduce
To 0.2-0.5%, improve the bad problem of taste；Increase-volume also is assisted using propylene glycol, promotes transparency.Addition is assisted to increase cool
Menthol brings pure and fresh mouthfeel and does not stimulate oral cavity.In terms of sweet taste, while using sorbierite and xylitol, addition three
Chlorine galactolipin coordinates the preparation method used, abandons traditional sweetener saccharin sodium, has rear hardship so as to dispel its weak flavor
Shortcoming brings pleasant suitable mouth feeling experience.Finally, the mouthfeel of mouthwash is promoted on the whole, promotes customer experience.
Specific embodiment
This hair can be further well understood by the specific embodiment and comparing embodiment of invention now given below
It is bright, but they are not limitation of the invention.It is to use not have the part described in detail in specific embodiment and comparing embodiment
What the prior art, known technology means and professional standard obtained.
Unless otherwise specified, the conventional hand that the technological means employed in embodiment is well known to those skilled in the art
Section, used reagent and product are also available commercial.The source of agents useful for same, trade name are with it is necessary to list its group
Into ingredient person, indicate on the first appearance.
Embodiment 1
Multi-efficiency type mouthwash includes the composition of following parts by weight：71.849 parts by weight of water, 20 parts by weight of sorbierite,
3 parts by weight of glycerine, 3 parts by weight of propylene glycol, 0.3 parts by weight of Cremophor RH40, -200.3 parts by weight of polysorbate, benzene
0.3 parts by weight of sodium formate, 0.3 parts by weight of Radix Notoginseng extracting solution, 0.3 parts by weight of Flos Lonicerae extractive solution, 0.1 parts by weight of menthol, wood
0.1 parts by weight of sugar alcohol, 0.1 parts by weight of essence, 0.1 parts by weight of stephania tetrandra extract, 0.05 parts by weight of methyl hydroxybenzoate, nipalgin
0.05 parts by weight of ethyl ester, 0.05 parts by weight of tranexamic acid, western 0.05 parts by weight of arsenic oronain, 0.05 parts by weight of Paeonol, trichlorine half
0.001 parts by weight of lactose.
Its preparation method, includes the following steps：
Western arsenic oronain, Paeonol, tranexamic acid, menthol, methyl hydroxybenzoate and ethylparaben are added completely into first
It in essence, can suitably 40 DEG C of water-bath be dissolved, be added in after dissolving completely to Cremophor RH40 and polysorbate -20
In stir evenly, add propylene glycol and be pre-mixed；Xylitol, tri-chloro galactose type sugar, Flos Lonicerae extractive solution, Radix Notoginseng extracting solution,
After being dissolved completely in water under stephania tetrandra extract, sodium benzoate room temperature, sorbierite and glycerine are added in, stirs evenly, will mix molten
The premix solved pours into, and opens stirring 20-30min and is uniformly mixed；Then pH value adjustment control is carried out, is aged 24 hours；
To enhance the transparency, the mechanical admixtures such as the fiber brought into manufacturing process are dispelled, discharging process need to add in filter device, before filling
It is filtered again.
Embodiment 2
Propolis is good for flute profile mouthwash, includes the composition of following parts by weight：75.339 parts by weight of water, 18 parts by weight of sorbierite,
2 parts by weight of glycerine, 2 parts by weight of propylene glycol, 0.5 parts by weight of Cremophor RH40, -200.5 parts by weight of polysorbate, three
Seven extracting solutions, 0.3 parts by weight, 0.3 parts by weight of Flos Lonicerae extractive solution, 0.3 parts by weight of sodium benzoate, 0.2 parts by weight of menthol, wood
0.1 parts by weight of sugar alcohol, 0.1 parts by weight of essence, 0.15 parts by weight of stephania tetrandra extract, 0.05 parts by weight of methyl hydroxybenzoate, Ni Bo
Golden 0.05 parts by weight of ethyl ester, 0.05 parts by weight of tranexamic acid, 0.05 parts by weight of Paeonol, 0.01 parts by weight of propolis extract, three
0.001 parts by weight of chlorine galactolipin.
Its preparation method, includes the following steps：
Paeonol, tranexamic acid, menthol, propolis extract, methyl hydroxybenzoate and ethylparaben are added completely first
Enter in essence, can suitably 40 DEG C of water-bath be dissolved, added in after dissolving completely to Cremophor RH40 and polysorbate-
It is stirred evenly in 20, adds propylene glycol and be pre-mixed；Xylitol, tri-chloro galactose type sugar, Flos Lonicerae extractive solution, Radix Notoginseng extraction
After being dissolved completely in water under liquid, stephania tetrandra extract, sodium benzoate room temperature, sorbierite and glycerine are added in, stirs evenly, will mix
The premix dissolved pours into, and opens stirring 20-30min and is uniformly mixed；Then pH value adjustment control is carried out, ageing 24 is small
When；To enhance the transparency, the mechanical admixtures such as the fiber brought into manufacturing process are dispelled, discharging process need to add in filter device, fill
It is filtered again before dress.
Embodiment 3
Pure and fresh salt is felt well type mouthwash, includes the composition of following parts by weight：74.799 parts by weight of water, 18 parts by weight of sorbierite,
2 parts by weight of glycerine, 2 parts by weight of propylene glycol, 0.9 parts by weight of sodium chloride, 400.4 parts by weight of Cremophor RH40, poly- sorb
- 200.4 parts by weight of alcohol ester, 0.3 parts by weight of Radix Notoginseng extracting solution, 0.3 parts by weight of Flos Lonicerae extractive solution, 0.2 weight of menthyl lactate
Part, 0.2 parts by weight of sodium benzoate, 0.1 parts by weight of xylitol, 0.1 parts by weight of essence, 0.1 parts by weight of stephania tetrandra extract, Ni Bo
0.05 parts by weight of tortoise beetle ester, 0.05 parts by weight of ethylparaben, 0.05 parts by weight of tranexamic acid, 0.05 parts by weight of Paeonol, three
0.001 parts by weight of chlorine galactolipin.
Its preparation method, includes the following steps：
Paeonol, tranexamic acid, menthyl lactate, methyl hydroxybenzoate and ethylparaben are added completely into essence first
In, it can suitably 40 DEG C of water-bath be dissolved, be added in after dissolving completely to Cremophor RH40 with being stirred in polysorbate -20
It mixes uniformly, adds propylene glycol and be pre-mixed；Xylitol, tri-chloro galactose type sugar, Flos Lonicerae extractive solution, Radix Notoginseng extracting solution, powder are prevented
Own extract, sodium benzoate after being dissolved completely in water under sodium chloride room temperature, add in sorbierite and glycerine, stir evenly, will mix
The premix dissolved pours into, and opens stirring 20-30min and is uniformly mixed；Then pH value adjustment control is carried out, ageing 24 is small
When；To enhance the transparency, the mechanical admixtures such as the fiber brought into manufacturing process are dispelled, discharging process need to add in filter device, fill
It is filtered again before dress.
Embodiment 4
Multiple-effect antiallergic type mouthwash includes the composition of following parts by weight：75.199 parts by weight of water, 18 parts by weight of sorbierite,
2 parts by weight of glycerine, 2 parts by weight of propylene glycol, 0.5 parts by weight of Cremophor RH40, -200.5 parts by weight of polysorbate, three
Seven extracting solutions, 0.3 parts by weight, 0.3 parts by weight of Flos Lonicerae extractive solution, 0.3 parts by weight of sodium benzoate, 0.2 parts by weight of menthol, wood
0.1 parts by weight of sugar alcohol, 0.1 parts by weight of essence, 0.15 parts by weight of stephania tetrandra extract, 0.15 parts by weight of dipotassium glycyrrhizinate, Ni Bo
0.05 parts by weight of tortoise beetle ester, 0.05 parts by weight of ethylparaben, 0.05 parts by weight of tranexamic acid, 0.05 parts by weight of Paeonol, three
0.001 parts by weight of chlorine galactolipin.
Its preparation method, includes the following steps：
Paeonol, tranexamic acid, menthol, methyl hydroxybenzoate and ethylparaben are added completely into essence first, it can
Appropriate 40 DEG C of water-bath is dissolved, and is dissolved complete rear add in and is stirred into Cremophor RH40 and polysorbate -20
It is even, it adds propylene glycol and is pre-mixed；Xylitol, tri-chloro galactose type sugar, Flos Lonicerae extractive solution, Radix Notoginseng extracting solution, Fourstamen Stephania Root carry
It takes after being dissolved completely in water under object, sodium benzoate, dipotassium glycyrrhizinate room temperature, adds in sorbierite and glycerine, stir evenly, will mix
The premix dissolved pours into, and opens stirring 20-30min and is uniformly mixed；Then pH value adjustment control is carried out, ageing 24 is small
When；To enhance the transparency, the mechanical admixtures such as the fiber brought into manufacturing process are dispelled, discharging process need to add in filter device, fill
It is filtered again before dress.
Embodiment 5
Mrs's multiple-effect series mouthwash includes the composition of following parts by weight：74.999 parts by weight of water, 18 weight of sorbierite
Part, 2 parts by weight of glycerine, 2 parts by weight of propylene glycol, 0.5 parts by weight of Cremophor RH40, -200.5 weight of polysorbate
Part, 0.3 parts by weight of Radix Notoginseng extracting solution, 0.3 parts by weight of Flos Lonicerae extractive solution, 0.3 parts by weight of sodium benzoate, 0.2 weight of menthol
Part, 0.2 parts by weight of sodium pyrophosphate, 0.1 parts by weight of xylitol, 0.1 parts by weight of essence, 0.15 parts by weight of stephania tetrandra extract are sweet
0.15 parts by weight of oxalic acid dipotassium, 0.05 parts by weight of methyl hydroxybenzoate, 0.05 parts by weight of ethylparaben, 0.05 weight of tranexamic acid
Part, 0.05 parts by weight of Paeonol, tri-chloro galactose type 0.001 parts by weight of sugar.
Its preparation method, includes the following steps：
Paeonol, tranexamic acid, menthol, methyl hydroxybenzoate and ethylparaben are added completely into essence first, it can
Appropriate 40 DEG C of water-bath is dissolved, and is dissolved complete rear add in and is stirred into Cremophor RH40 and polysorbate -20
It is even, it adds propylene glycol and is pre-mixed；Xylitol, tri-chloro galactose type sugar, Flos Lonicerae extractive solution, Radix Notoginseng extracting solution, Fourstamen Stephania Root carry
It takes after being dissolved completely in water under object, sodium benzoate, dipotassium glycyrrhizinate and sodium pyrophosphate room temperature, adds in sorbierite and glycerine, stirring
Uniformly, the good premix of mixed dissolution is poured into, opens stirring 20-30min and be uniformly mixed；Then pH value adjustment control is carried out
System is aged 24 hours；To enhance the transparency, the mechanical admixtures such as the fiber brought into manufacturing process are dispelled, discharging process needs to add in
Filter device is filtered again before filling.
Comparative example 1
Traditional mouthwash, including following components by weight percent：67.4 parts by weight of water, 0.1 parts by weight of essence, 0.1 weight of menthol
Part, 0.1 parts by weight of saccharin sodium, 10 parts by weight of ethyl alcohol, 20 parts by weight of sorbierite, 0.3 parts by weight of sodium benzoate, 2 parts by weight of glycerine.
Its preparation method, includes the following steps：
First by essence, menthol is added in ethyl alcohol, can suitably 40 DEG C of water-bath be pre-mixed；Saccharin sodium, sorbierite, benzene
After being dissolved completely in water under sodium formate, glycerine room temperature, the good premix of mixed dissolution is poured into, stirring 20-30min is opened and mixes
It closes uniform；Then pH value adjustment control (3-10.5) is carried out, is aged 24 hours；To enhance the transparency, band in manufacturing process is dispelled
The mechanical admixtures such as the fiber entered, discharging process need to add in filter device, be filtered again before filling.
Indices test, obtained test result such as 1 institute of table are carried out to the mouthwash of embodiment 1 to 5 and comparative example 1
Show.
According to《QB/T 2945-2012 oral cavity cleaning and nursing liquid》Requirement, ready-made water sample of gargling is divided into 6 groups, often
4 parts of group, label is posted with the transparent sample of 100ml is bottled well, is respectively placed in 40 DEG C of baking ovens, 4 DEG C of refrigerators, room temperature, window light and is shone
Under four kinds of experiment conditions, observing time for for 24 hours, 48h, 7d, 14d, 28d.Whether observation item is there is muddy or visible machinery
Impurity, while measure the variation of pH value.By tracking test, embodiment 1-5 formulation stables, phenomenon without exception.The height of comparative example
Warm test sample (hot conditions are amplification Acceleration studies, and 28d simulations are the phenomenon that room temperature 1-2 occur) is when 28d is observed
There is fraction of impurity to occur, pH value changes greatly, and total plate count and mould change greatly with saccharomycete sum, especially mould and ferment
Female bacterium sum, infers that its formulation stability is poor, is unfavorable for preserving for a long time, influence the function and effect of product.The number embodied in table 1
Terminate data according to for original state experimental data and 28d stability experiments, omission for 24 hours, 48h, 7d, 14d experimental data is no different
It does not embody often therefore.
The base values test result of 1 mouthwash of table
The test of preservation challenge is carried out to embodiment 1-5 and comparative example, test result is as follows table 2-1, shown in 2-2.
Preservation challenge test method refers to United States Pharmacopeia USP35-<51>.Specific method is as described below：
1. the preparation of bacterial suspension：The fresh slant culture cultivated 18~24 hours is washed down with physiology salt, profit
108CFU/mL bacteria suspensions are made with turbidimetry dilution.3 kinds of bacterial suspensions are mixed in equal volume, 4 DEG C spare.
2. the preparation of fungi suspension：The Candida albicans of 44~52 hours, the black song of culture 6~10 days will be cultivated respectively
108CFU/mL bacteria suspensions are made under the mould washing with physiology salt and using turbidimetry.Both the above fungi suspension is mixed in equal volume
It closes, 4 DEG C spare.
3. sample inoculation：It weighs sample to be packed into sterile sampling bottle, the mixed cell for being separately added into 1.0% sample size is suspended
Liquid and mixed fungus suspension are sufficiently mixed uniformly, sample are placed under 22.5 ± 2.5 DEG C of environment temperatures and is preserved, respectively at 0,
2nd, the clump count in 7,14,21,28 days sampling detection samples.
4. sample detection：10g samples is taken to add in 90mL sterile salines and are diluted to 1:10 sample diluting liquid, when necessary
It is diluted to convenient multiple.The inspection liquid 2mL of acceptable diluent degree is chosen, is injected separately into two sterilizes culture dishes, per ware 1mL.With
Cool to 40 DEG C~45 DEG C of TSA culture mediums (bacterium) or sabouraud's agar (fungi) 15ml pours into, and rotates plate, makes it
It is full and uniform, tablet, 35 DEG C of cultures 3 days (bacterium) are overturn after agar solidification, 25 DEG C of cultures 3-5 days (fungi) make viable bacteria bacterium
Fall counting.
Table 2-1 mouthwash preservation challenge test reports (total number of bacteria)
Table 2-2 mouthwash preservation challenge test reports (mould)
It can be seen that from table 2-1,2-2, embodiment 1-5 is stronger to the anti-corrosion ability of bacterium and mould, is not easy by strain dirt
Dye, comparative example is fine to the anti-corrosion ability of bacterium, weaker for the anti-corrosion ability of mould.
Efficacy test：
For the effect disquisition of embodiment and comparative example, subject of the random selection with different degrees of oral problem carries out
Patient 200 is tested, the standard of selection is：Meet Western medicine diagnostic criteria and differential diagnosis in tcm standard, age between 18~55 years old,
Wherein, women 100, male 100.Above-mentioned case is divided into totally 6 groups of embodiment group and comparative example group at random, embodiment and right
The effect of ratio medicament test effect is shown in Table 3.The daily breakfast, lunch and dinner of subject using different mouthwashes, adhere to using by surrounding after the meal
After time, into line trace and the profession observation of dentistry.As a result such as the following table 3,
3 mouthwash trial state result of table
Embodiment can be seen that with comparative example from table, and the mouthwash containing Fourstamen Stephania Root and Chinese medical extract is a variety of with improving
The effect of oral problem；From embodiment 1-5's the results show that promotion of stephania tetrandra extract dosage can slightly improve effect；It is real
Example 4 is applied the results show that stephania tetrandra extract is used in compounding with dipotassium glycyrrhizinate has preferable effect to sensitivity of tooth.
It is above disclosed to be merely a preferred embodiment of the present invention, the right of the present invention cannot be limited with this certainly
Range, therefore the equivalent variations made according to scope of the present invention patent, are still within the scope of the present invention.
Claims (10)
1. multi-efficiency type mouthwash, it is characterised in that：Include the composition of following parts by weight：Solubilizer 2.8-3.6 parts by weight, it is sweet
Oily 2-3 parts by weight, effect additive 0.8-1.1 parts by weight, preservative 0.3-0.4 parts by weight, taste-modifier 18.4-20.3 weights
Part is measured, surplus is water.
2. multi-efficiency type mouthwash according to claim 1, it is characterised in that：The effect of described additive be Fourstamen Stephania Root
Extract, Notogineng Extract, Honegsukle flower P.E, tranexamic acid, Paeonol, propolis extract, western arsenic oronain and glycyrrhizic acid two
The two or more combinations of potassium.
3. multi-efficiency type mouthwash according to claim 2, it is characterised in that：Effect additive is carried for Fourstamen Stephania Root
Take in object, Notogineng Extract, Honegsukle flower P.E, tranexamic acid, Paeonol and western arsenic oronain two or more is used in compounding.
4. multi-efficiency type mouthwash according to claim 1, it is characterised in that：The preservative is sodium benzoate, Buddhist nun
Moor one or more of tortoise beetle ester and ethylparaben.
5. multi-efficiency type mouthwash according to claim 4, it is characterised in that：The preservative sodium benzoate, Ni Bo
3 kinds of tortoise beetle ester and ethylparaben are used in compounding, ratio 4:1:1.
6. multi-efficiency type mouthwash according to claim 1, it is characterised in that：The taste-modifier for saccharin sodium,
One or more of sorbierite, tri-chloro galactose type sugar, xylitol, menthol, menthyl lactate, sodium chloride and essence；Its
Middle sorbierite, saccharin sodium, tri-chloro galactose type sugar, xylitol are sweetener；Menthol is coolant agent with menthyl lactate, and usage amount is
0.1-0.2 parts by weight.
7. multi-efficiency type mouthwash according to claim 6, it is characterised in that：The sweetener uses sorbierite, three
Chlorine galactolipin, xylitol are used in compounding, ratio 20:0.05:0.1.
8. multi-efficiency type mouthwash according to claim 1, it is characterised in that：The solubilizer is ethyl alcohol, PEG-40
It is one or more in rilanit special, polysorbate -20 and propylene glycol.
9. multi-efficiency type mouthwash according to claim 8, it is characterised in that：The solubilizer hydrogenates castor for PEG-40
- 20 ratio 1 of sesame oil and polysorbate:1 is used in compounding.
10. a kind of preparation method of the multi-efficiency type mouthwash described in claim 1 to 9, it is characterised in that：Described is multiple
The preparation method of effect type mouthwash, step are：First water to be insoluble in the effect of additive, methyl hydroxybenzoate and nipalgin
After ethyl ester is dissolved completely in essence, adds in Cremophor RH40 with being stirred evenly in polysorbate -20, add in the third two
It is pre-mixed in alcohol；Water-soluble effect additive is dissolved completely in sweetener, sodium benzoate in water, adds in sorbierite and glycerine,
After stirring evenly, the good premix of mixed dissolution is poured into, stirring 20-30min is opened and is uniformly mixed；Then pH value control is carried out
System is aged 24 hours；To enhance the transparency, the mechanical admixtures such as the fiber brought into manufacturing process are dispelled, discharging process needs to add in
Filter device filters again before filling.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388610A (en) * | 2020-04-09 | 2020-07-10 | 四川绿色本草科技发展有限公司 | Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
| WO2020159721A1 (en) * | 2019-02-01 | 2020-08-06 | Colgate-Palmolive Company | Preservative systems for oral care compositions |
| CN111728905A (en) * | 2020-06-02 | 2020-10-02 | 福州安得尔卫生技术开发有限公司 | Plant gargle |
| CN112043615A (en) * | 2020-09-26 | 2020-12-08 | 福建省梦娇兰日用化学品有限公司 | Children's mouthwash containing arsenic trioxide bacteriostatic agent and preparation method thereof |
| CN112315888A (en) * | 2020-10-13 | 2021-02-05 | 上海格芒商贸有限责任公司 | Suspended oil drop mouth wash and preparation method thereof |
| CN113181102A (en) * | 2021-03-09 | 2021-07-30 | 北京圣永制药有限公司 | Mouthwash with functions of moistening oral cavity and refreshing breath and preparation method thereof |
| CN113244155A (en) * | 2021-05-19 | 2021-08-13 | 广州冰泉化妆品科技有限公司 | Compound antibacterial mothproof mouthwash and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963190A (en) * | 2016-06-21 | 2016-09-28 | 江苏奇力康皮肤药业有限公司 | Antisepsis and anti-inflammation mouth wash |
| CN106265423A (en) * | 2016-08-23 | 2017-01-04 | 广州立白企业集团有限公司 | Having relieves inflammation or internal heat disappear pain effect oral care composition |
| CN107349171A (en) * | 2017-07-27 | 2017-11-17 | 安徽省银锂子生物科技发展有限公司 | A kind of effectively antibacterial, sterilization and the mouthwash for accelerating canker sore healing |
-
2018
- 2018-03-19 CN CN201810224269.6A patent/CN108186541A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963190A (en) * | 2016-06-21 | 2016-09-28 | 江苏奇力康皮肤药业有限公司 | Antisepsis and anti-inflammation mouth wash |
| CN106265423A (en) * | 2016-08-23 | 2017-01-04 | 广州立白企业集团有限公司 | Having relieves inflammation or internal heat disappear pain effect oral care composition |
| CN107349171A (en) * | 2017-07-27 | 2017-11-17 | 安徽省银锂子生物科技发展有限公司 | A kind of effectively antibacterial, sterilization and the mouthwash for accelerating canker sore healing |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020159721A1 (en) * | 2019-02-01 | 2020-08-06 | Colgate-Palmolive Company | Preservative systems for oral care compositions |
| CN113329730A (en) * | 2019-02-01 | 2021-08-31 | 高露洁-棕榄公司 | Preservative system for oral care compositions |
| US11786762B2 (en) | 2019-02-01 | 2023-10-17 | Colgate-Palmolive Company | Preservative systems for oral care compositions |
| CN111388610A (en) * | 2020-04-09 | 2020-07-10 | 四川绿色本草科技发展有限公司 | Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
| CN111728905A (en) * | 2020-06-02 | 2020-10-02 | 福州安得尔卫生技术开发有限公司 | Plant gargle |
| CN112043615A (en) * | 2020-09-26 | 2020-12-08 | 福建省梦娇兰日用化学品有限公司 | Children's mouthwash containing arsenic trioxide bacteriostatic agent and preparation method thereof |
| CN112315888A (en) * | 2020-10-13 | 2021-02-05 | 上海格芒商贸有限责任公司 | Suspended oil drop mouth wash and preparation method thereof |
| CN113181102A (en) * | 2021-03-09 | 2021-07-30 | 北京圣永制药有限公司 | Mouthwash with functions of moistening oral cavity and refreshing breath and preparation method thereof |
| CN113244155A (en) * | 2021-05-19 | 2021-08-13 | 广州冰泉化妆品科技有限公司 | Compound antibacterial mothproof mouthwash and preparation method thereof |
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Application publication date: 20180622 |