CN108077911A - A kind of epileptic's tailored version clinical nutrition formula and preparation method thereof - Google Patents

A kind of epileptic's tailored version clinical nutrition formula and preparation method thereof Download PDF

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CN108077911A
CN108077911A CN201711331581.7A CN201711331581A CN108077911A CN 108077911 A CN108077911 A CN 108077911A CN 201711331581 A CN201711331581 A CN 201711331581A CN 108077911 A CN108077911 A CN 108077911A
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parts
vitamin
powder
epileptic
clinical nutrition
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尤俊
季敬东
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Shanghai Olympic Medical Biotechnology Co Ltd
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Shanghai Olympic Medical Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/17—Amino acids, peptides or proteins
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
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    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
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    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/25—Synthetic polymers, e.g. vinylic or acrylic polymers
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention provides a kind of epilepsy tailored version clinical nutrition formula, including following component and its parts by weight：10 22 parts of protein, 32 55 parts of fat, 6 25 parts of carbohydrate, 79 parts of dietary fibers, 0.6 1.2 parts of macroelements, 0.01 0.04 parts of trace elements, 0.005 0.03 parts of liposoluble vitamins, 0.008 0.2 parts of water soluble vitamins, 0.05 1 parts of meals elite, 0.06 2 parts of integration of drinking and medicinal herbs ingredients and 0.005 2 parts of new resource foods；The present invention also provides a kind of preparation methods of above-mentioned clinical nutrition formula.The present invention can either effectively treat epilepsy syndromes, and can alleviate side effect caused by high fat diet therapy.

Description

A kind of epileptic's tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to special medicine purposes formula food field more particularly to a kind of epileptic's tailored version clinical nutritions Formula and preparation method thereof.
Background technology
Epilepsy (epilepsy) is a kind of disease of brain, its main feature is that persistently there are epilepsy recurrent exerbations in brain tissue Neurological susceptibility and thus caused nerve biochemistry, cognition, psychology and societal consequence.At present, there are about 50 × 106 epilepsies in the whole world Patient, wherein 80% in developing country, about more than 9 × 106 example patient of China, still newly-increased more than 450 × 103 examples, living at present every year Dynamic venereal disease example about 6.50 × 106, wherein rural area account for 2/3, and treatment gap is up to 70%.The therapy of epilepsy is still at present So based on Long-term Oral antiepileptic (AEDs), especially some intractable epilepsy types generally require multi-medicament connection Treatment is closed, and may be taken medicine throughout one's life.
Epilepsy is a kind of nervous system syndrome, have the characteristics that suddenly generation, recurrent exerbation, clinical manifestation for movement, The different degrees of obstacle of the generations such as sensation, consciousness, autonomic nerve, spirit, but it is inherently cerebral neuron paradoxical discharge And then cause of short duration brain function not normal.Current medical level can't cure the disease completely, mostly based on control.In recent years The research come shows the paradoxical discharge of this neuron and neurotransmitter, ion channel, Deiter's cells, synaptic contact, something lost It passes and immune etc. exception has substantial connection.
Antiepileptic Endocrine and human metabolism function have a variety of harmful effects.For example, valproic acid therapeutic process In there is serum insulin level rise, weight increases and hyperinsulinemia.All antiepileptics are to thyroid hormone Secretion have an impact.Easy concurrent secondary hyperthyroidism, exchanging magnesium in body during hyperthyroidism increases, and urine row's magnesium increases, thyroxine energy Thyroxine is excessive when directly stimulating the operating of magnesium in cell and causing magnesium negative balance and hyperthyroidism, increases Na+-K+-ATP enzymes Activity promotes oxidative phosphorylation, and oxygen consumption and heat production increase, and cause magnesium metabolic disorder.
Long-term use of antiepileptic can also result in osteoporosis.For example, it can be increased by the antiepileptic of enzyme induction Add the metabolism of liver vitamin D, reduce Calcium-ion absorption；Rather than the antiepileptic (such as sodium vedproate) of enzyme induction can lead to It crosses the synthesis of 2 vitamine D3s of reduction 1,25- (OH) and declines osteoblast function.Accelerate the catabolism of activated vitamin D, Cause that activated vitamin D is substantially reduced and Ca,P metabolism is disorderly, cause secondary hyperthyroidism, make bone metabolism disturbance, Bone density reduces.
Long-term use of antiepileptic may make part intractable epilepsy infant occur or aggravate its abnormal behavior and spirit Symptom, for example, enhancing γ-aminobutyric acid (GABA) activity antiepileptic can making patients mental symptom, especially Depressive symptom.
The study found that valproic acid has certain influence to patient's sexual function.One male's intractable epilepsy to taking valproic acid The clinical observation of epilepsy patient shows the patients serum's androgen levels rise for having 60% respectively, 50% patient's testosterone levels liter It is high.Moreover, the risk that the women epileptic for receiving valproic acid treatment suffers from more ovary sample syndromes increases.
High fat diet as treatment epilepsy report can trace back to earliest in the early 1920s, at present high fat diet Through the optional treatment that treatment of intractable epilepsy is classified as by various countries' guide.High fat diet is a kind of high in fat, appropriate protein, low-carbon Hydrate diet, by forcing human body burn fat and non-carbohydrate, simulation starvation.Simply, it is exactly more Grease is eaten, eats rice and flour grain less.So that insulin reduces, glycogen is depleted, and adipose conversion is ketoboidies, and is supplied for body and brain Energy.Scientist speculates that brain is converted into from glucose energy supply by ketoboidies, and neuronal excitability and electric discharge can be caused to reduce, inhibited Acidic amino acid is horizontal to be increased, so as to reduce epileptic attack.However, compared with comprehensive epilepsy, high fat diet is to partial insane Epilepsy may less effective.
Clinical treatment epilepsy is still based on oral antiepileptic at present, takes orally the pair there are many antiepileptics Effect, high fat diet clinically treats epilepsy, there is limitation, only effective to partial epilepsy, and high fat diet also has ignored Influence of other nutrients to epileptic attack.Western medical treatment epileptics relies primarily on antiepileptic, secondary although it is rapid to work Act on more, the compliance and tolerance of patient is poor.In recent years, clinical research is found, this disease of Chinese traditional treatment has definite effect Fruit, few side effects, but it is slower to work.
For this purpose, epilepsy syndromes can either be alleviated by developing, and needed nutrient matter, the immunity of organisms for enhancing patient can be supplemented Nutritional formulas be that there is important value and wide market.
The content of the invention
The defects of it is an object of the invention to overcome in the prior art, provides a kind of epileptic's tailored version clinical nutrition and matches somebody with somebody Side and preparation method thereof according to the clinical nutrition feature of epilepsy, particularly children with intractable epilepsy, uses high protein high in fat Matter low-carb simulates starvation using high fat diet, effectively treats epilepsy syndromes；Appropriate supplement magnesium simultaneously, calcium, B family vitamin and vitamin D can enhance immunity of organisms, promote brain blood Xun Huan, further treat epilepsy syndromes, and Side effect caused by high fat diet therapy can be alleviated.
To achieve the above object, the present invention adopts the following technical scheme that：
First purpose of the present invention is to provide a kind of epilepsy tailored version clinical nutrition formula, including following component and its again Measure number：10-22 parts of protein, 32-55 parts of fat, 6-25 parts of carbohydrate, 7-9 parts of dietary fibers, 0.6-1.2 parts of constants Element, 0.01-0.04 parts of trace elements, 0.005-0.03 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamins, 0.05-1 parts of meals elite, 0.06-2 parts of integration of drinking and medicinal herbs ingredients and 0.005-2 parts of new resource foods.
Preferably, the protein be PURE WHEY, it is soybean protein isolate, hydrolysis Isin glue collagen, whole milk powder, complete At least one of powdered egg, lactoferrin, colostrum, amino acid, protein peptides.
Wherein, the amino acid is L-lysine-Pidolidone, Pidolidone, L-arginine, L-Trp, L- paddy ammonia At least one of amide, taurine, Valine, l-Isoleucine, L-Leu；The protein peptides for soybean oligopeptide, At least one of wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide.
Preferably, it is described fat for saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structured lipids, At least one of DHA, EPA, ARA, phosphatide.
Preferably, the carbohydrate is fructose, in rock sugar, lactose, maltodextrin, tapioca, resistant starch At least two.
Preferably, the dietary fiber be inulin, it is konjaku flour, galactooligosaccharide, oligofructose, oligoisomaltose, big At least one of beans polysaccharide, cyclodextrin, resistant dextrin, soybean fiber.
Preferably, the macroelement for calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate and At least one of magnesium gluconate.
Preferably, the trace element is ferrous gluconate, potassium iodide, zinc gluconate, sodium selenite, gluconic acid At least one of copper, chromium sulfate, manganese gluconate and sodium molybdate.
Preferably, the liposoluble vitamin is vitamin A, beta carotene, vitamin D3, vitamin E, vitamin K1In At least one.
Preferably, the water soluble vitamin is vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, At least one of pantothenic acid, folic acid, niacin, choline, inositol, biotin.
Preferably, the meals elite for cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fish and shrimp, At least one of poultry meat, fruits.
Wherein, the cereal is selected from rice meal, millet powder, black rice flour, coixlacrymajobi powder, corn flour, wheat germ powder, oat At least one of powder, buckwheat；The beans in peameal, mung bean flour, black bean powder, red bean powder, soy meal at least It is a kind of；The potato is mainly made of common yam rhizome powder；The greengrocery be selected from carrot meal, white radish powder, pumpkin powder, spinach powder, kind At least one of eggplant powder, broccoli powder, balsam pear powder；The Homonemeae in mushroom powder, Kelp Powder and white fungus powder at least It is a kind of；The nut-seed class is mainly made of pumpkin seed powder and lotus nut starch；The fish and shrimp are selected from salmon powder and cod meal At least one of；The poultry meat is selected from least one of chicken meal, powdered beef and pig kidney powder；The fruits are selected from At least one of red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder.
Preferably, the integration of drinking and medicinal herbs ingredient be Poria cocos, it is spina date seed, peach kernel, Chinese yam, oyster, black pepper, oyster, sweet At least one of grass；More preferably Poria cocos, spina date seed, peach kernel, Chinese yam, oyster, black pepper.
Preferably, the new resource food is first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, the leaf of bamboo In flavones, casein phosphopeptide, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii Tratt, xylo-oligosaccharide It is at least one；More preferably γ-aminobutyric acid.
Above-mentioned nutrient formulation may also include 0.1-3 parts of natural plants compounds.
Preferably, the natural plants compound is l-cn, Glucosamine, oligofructose, lutein, plant steroid At least one of alcohol, lycopene, resveratrol, allicin；More preferably l-cn.
Above-mentioned nutrient formulation may also include nucleotide；The nucleotide is 5 ' monophosphate cytidines.
Second object of the present invention is to provide a kind of preparation method of above-mentioned epileptic's tailored version clinical nutrition formula, It includes the following steps：
Step 1, fat powder, liposoluble vitamin powder and water soluble vitamin powder are prepared using micro-capsule embedding techniques End；
Step 2, carried, be spray-dried and sifting step prepares integration of drinking and medicinal herbs component powders using crushing, alcohol extracting, water；
Step 3, by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals essence China, natural plants compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively；
Step 4, powder prepared by step 1~3 is sterilized after mixing spare；
Step 5, the mixed powder of step 4 is prepared by nutrient powder, nutrition emulsion, capsule according to conventional technical means At least one of agent, tablet, pill or oral liquid；
Wherein, the order of step 1~3 can be replaced mutually.
Finally, the present invention provides a kind of product prepared by above-mentioned puerperal abdominal flatulence gas tailored version clinical nutrition formula, including Nutrient powder, nutrition emulsion, capsule, tablet, pill, oral liquid etc..
Preferably, in the step 5, suitable food thickening agent and food additives are optionally increased.
Wherein described food thickening agent is guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, bright At least one of glue, Arabic gum；The food additives are at least one in Aspartame, food flavor fragrance, brown sugar Kind.
More preferably described food thickening agent is carragheen, Arabic gum, guar gum；The food additives are A Siba Sweet tea, food flavor fragrance.
Preferably, the step 1-5 is both needed to carry out under the protection of inert gas, to prevent the danger of powder explosion Danger.
Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number Raw material crushes, and the raw material of crushing is placed in container, adds in 3~8 times of the water that weight is raw material weight, carries out immersion 3 ~4 it is small when, then carry out 30~60min of decoction to soak, filtering removal raw material leaves and takes decoction liquor, decoction liquor is sprayed Mist is dried, and integration of drinking and medicinal herbs component powders are prepared with 60~80 mesh sieves point.
Preferably, the specific implementation step of the micro-capsule embedding techniques of the fat is as follows：A) wall material aqueous solution is prepared：Take wheat Bud dextrin, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, Arabic gum, candy sugar powder and water stir evenly, and obtain wall material aqueous solution；B) monoglyceride is taken and be dissolved in grease；C) by tween 80 are dissolved in wall material aqueous solution；D) liquid of blend step b) and step c), obtains mixed solution；E) stabilizer agar is added In mixed solution, constant volume, high speed dispersion under 20000r/min；F) homogenization pressure is 25MPa, and homogeneous emulsus is made in homogeneous 3 times Liquid；G) emulsion obtained is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, collects and obtains fatty powder End.
Preferably, the micro-capsule embedding techniques of the vitamin is as follows：By the fat-soluble of predetermined weight number Vitamin selects carragheen, Arabic gum to carry out 2 emulsifying homogeneous processing under high pressure, emulsification is equal as wall material as core The matter time is 10~15min, then carries out instantaneous drying of spraying, and liposoluble vitamin powder is prepared with 60~80 mesh sieves point；It will The water soluble vitamin of predetermined weight number selects maltodextrin, lipoprotein to be uniformly mixed, spraying as wall material as core It is instantaneous dry, prepare water soluble vitamin powder with 60~80 mesh sieves point.
High fat diet be a fat at high proportion, the low ratio of carbohydrate, protein and other nutrients are suitably matched somebody with somebody Square diet, other states for simulating human body starvation, can effectively treat children with intractable epilepsy.It treats the mechanism of epilepsy For：
1. change the energetic supersession mode of brain.
2. change cell characteristics, reduce excitability and buffer epileptiform discharges.
3. changing neurotransmitter, cynapse is transferred, the function of neuromodulator.
4. changing the extracellular environment of brain, excitability and synchronism are reduced.
High fat diet changes human body regular diet structure and energy supply source, and body and brain are required for an adaptation The process of this variation, is during which likely to occur the malaise symptoms such as headache, weak, diarrhea, vomiting, it is necessary to which 4 weeks~8 weeks just adapt to This process；And although the change being metabolized in vivo is beneficial to the stabilization of cerebral nerve cynapse, may also be brought to other systems Side effect, such as the side effects such as osteoporosis, fracture, abnormal bone metabolism, body immunity decline.Being used in the present invention includes The nutrition of unrighted acid, at high proportion calcium, multivitamin (especially vitamin B), integration of drinking and medicinal herbs ingredient, new resource food Formula can effectively treat epilepsy syndromes, alleviate side effect caused by high fat diet therapy.
Being used in the present invention includes the integration of drinking and medicinal herbs ingredient of Poria cocos, spina date seed, peach kernel, Chinese yam, oyster, black pepper, on Stating after components compatibility synergy plays an important role of to calm the nerves that calm, enhancing is physical, clearing heat and detoxicating, replenishes the calcium, enhances body immunity.
Poria cocos mild in medicine property and, can invigorating the spleen, it is thin and weak to those prolonged illness, lose the appetite or have fatigue and asthenia, the deficiency of vital energy of diarrhea concurrently The weak patient of spleen helps spleen QI invigorating；Can mental-tranquilization, have sedation；Can relax gastrointestinal smooth muscle, tool Play the role of promoting digestion；Also there is the effect for enhancing body immune simultaneously, suitable for causing machine because of high fat diet therapy The epileptic that body immunocompetence declines.
Spina date seed is sweet in flavor, sour, mild-natured, fat oil containing volume and protein, and containing sterol, triterpenes, jujuboside, more Measure vitamin C；There are calmness, hypnosis, analgesia, anticonvulsant action；There is certain antihypertensive effect, suitable for deficiency of YIN-blood, palpitaition is seized with terror It is sad, insomnia forgetfulness；Body void hidrosis；The symptoms such as headache, weak can be alleviated.
Peach kernel bitter but sweet flavor and it is mild-natured, the heart, liver, large intestine can be entered, promoting blood circulation effect is very wide, additionally can effectively supplement body The energy of body and containing carbohydrate, carbohydrate, can contribute to provide energy, and Semen Persicae extract rapidly for body Necrosis of liver cells denaturation and fibrosis are suffered from improving in various degree, also there is certain protective effect for liver, fit For causing the symptoms such as breathes hard, body immunity decline because of high fat diet therapy.
Chinese yam, it is sweet in flavor, it is mild-natured, there is tonifying spleen nourishing the stomach, the benefits of engender liquid and benefic lung, kidney tonifying puckery essence, rich in 18 kinds of amino acid and More than 10 kind trace elements and other minerals, so having strengthening the spleen and stomach, tonifying lung kidney, tonifying middle-Jiao and Qi, invigorating the spleen qi-restoratives, reinforce the kidney beneficial essence, benefit The effects that heart and tranquilizing mind；Rich in calcium in Chinese yam, to injury of the tissues damage bone, osteoporosis, loss of tooth has the effect of high；Simultaneously rich in more Kind vitamin, amino acid and minerals can prevent Human Lipid Metabolism exception, there is enhancing body immunity, what invigorating heart was calmed the nerves Effect；Suitable for symptoms such as the headache caused by high fat diet therapy, the declines of weak, abnormal bone metabolism, body immunity.
The liver glycogen of oyster exist in the liver and muscle of stored energy, division, regeneration, the work of red blood cell with cell Property suffer from very deep relation, liver function can be improved, set up, enhancing muscle power；The contained taurine in oyster It can promote choleresis, exclude the neutral fat being deposited in liver, improve the detoxication of liver, so raw ketone can be alleviated The side effect that the drink high in fat of diet is brought improves physical function.
Black pepper is rich in containing vitamin A, vitamin B2, vitamin C, pipering, volatile oil, starch, thiamine, copper, Iron, zinc, ketone, alcohol, enzyme etc., acrid flavour, property heat, enter stomach, large intestine channel；There is the effect of warming the middle warmer and descending qi, dissolving phlegm is detoxified, it is cold gastral cavity abdomen can be treated Bitterly, the symptoms such as gastric disorder causing nausea, vomiting, diarrhea, suitable for the malaise symptoms such as diarrhea, vomiting caused by high fat diet therapy.
The present invention compared with prior art, is had the following technical effect that using above-mentioned technical proposal：
Epileptic's tailored version clinical nutrition formula of the present invention is polyunsaturated fatty acid including ω -3, is beneficial to reduce The viscosity of blood promotes brain blood Xun Huan, reduces convulsions, alleviates children with intractable epilepsy symptom；
Add medium chain triglyceride, can while identical energy is provided produced more ketoboidies, effectively antagonize small Youngster's intractable epilepsy；
Monounsaturated fatty acids (MUFA) at high proportion, can reduce the generation of arrhythmia cordis and cardiac sudden death, and pre- child-resistant is insane Epilepsy is died suddenly；
Strengthen taurine, be capable of providing human body oxidation resistance, enhance immunity of organisms；
Strengthen calcium, calcium is the main component for forming children's bone and tooth, can promote upgrowth and development of children, and it is close to improve bone Degree；Low blood calcium is also one of the reason for epilepsy is caused to occur, therefore supplements enough calcium and can avoid epilepsy to a certain extent The generation of illness；
Strengthen iron, zinc, iron is the important element for forming hemoglobin, being capable of the pre- postoperative hypoferric anemia of child-resistant；Zinc is One of the essential trace elements of the human body is the constituent of a variety of enzymes, widely participates in various metabolic activities, be conducive to skin The normal growth of skin, bone and tooth promotes children's appetite, helps to enhance children physique, so as to which the body for enhancing children is exempted from Epidemic disease ability；
A variety of water solubility type vitamin rational proportions, vitamin C can enhance the metabolism of nerve cell, to lipid metabolism Also have a certain impact, help to improve the speed of cholesterol transformation cholic acid, strengthen vascular toughness；B family vitamin is that body is more The coenzyme of kind important biomolecule enzyme, participates in the synthesis and metabolism of many kinds of substance, especially neurotransmitter and quenched synthesis and release, Wherein vitamin B6Related with a kind of generation of γ-aminobutyric acid (inhibitory neurotransmitter), research shows VitB in serum6Contain Amount reduction is related with the generation of epilepsy, so one of the reason for Vitamin B6 deficiency may be epileptic attack；
A variety of fat-soluble type vitamin rational proportions, vitamin D can promote the absorption of calcium phosphorus, maintain calcium, phosphorus in blood Level promotes the growth of children's bone and tooth, and system is maintained to stablize, and alleviates epileptic attack；Vitamin E has inhibition brain tissue oxygen Change acts on, i.e. antioxidation, can remove the free radical of toxicity in humans；It or a kind of membrane stabilizer simultaneously, can be to prevent Only the permeability of brain cell increases, and plays the role of preventing convulsive seizure；
Integration of drinking and medicinal herbs ingredient is added, can effectively alleviate epilepsy syndromes, pipering in pepper powder extracts is caused less than half Under dead dosage, to rat and mouse caused by electroconvulsive shock, pentylenetetrazole, picrotoxin, strychnine, tubocurarine and sodium glutamate Convulsions has different degrees of antagonism, and can reduce the death rate of animal, reduces infantile convulsion number；In oyster extract Oyster aldehyde have apparent sedation to small white mouse, show as spontaneous activity reduction, can make children epilepsy state alleviate；Peach kernel Amarogentin in extract generates hydrogen cyanide and benzaldehyde after enteric bacteria hydrolyzes, the former has central antitussive effect；Acid Composition of alkaloids can make that the time fainted from fear occurs in mouse and the death time is obviously prolonged in jujube kernel extract；
0.1 part of new resource food γ-aminobutyric acid is added, γ-aminobutyric acid is a kind of inhibitory neurotransmitter, not only right Three continuous pathophysiological processes of difference of children epilepsy breaking-out play an important role, while have and promote pituitary growth hormone Effect, be one of Core amino acids needed for children's upgrowth and development.
The present invention using the proportioning of general equilibrium, while is added with tranquilizing the mind town by selecting rational basal nutrient element The specific nutrients such as quiet, enhancing is physical, clearing heat and detoxicating, new resource food, the integration of drinking and medicinal herbs ingredient of enhancing body immunity, and Adjust its proportioning with basal nutrient element carry out compatibility synergy, comprehensively supplement using high fat diet treat epileptic needed for must Must nutritional ingredient, and the nutrient formulation is easier the effect of being absorbed by people digest, giving full play to its each component, while has and carry The enhancing effect of produced more ketoboidies while for identical energy, so as to reach the function of preferably treating epilepsy, and Side effect caused by high fat diet therapy can be alleviated.
Specific embodiment
The present invention provides a kind of epileptic's tailored version clinical nutrition formula, including following component and its parts by weight： 10-22 parts of protein, 32-55 parts of fat, 6-25 parts of carbohydrate, 7-9 parts of dietary fibers, 0.6-1.2 parts of macroelements, 0.01-0.04 parts of trace elements, 0.005-0.03 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamins, 0.05-1 parts Meals elite, 0.06-2 parts of integration of drinking and medicinal herbs ingredients, 0.1-3 parts of natural plants compounds and 0.005-2 parts of new resource foods.
With reference to embodiment, the specific embodiment of the present invention is further described.Following embodiment is only used for more Add and clearly demonstrate technical scheme, and be not intended to limit the protection scope of the present invention and limit the scope of the invention.
Embodiment 1
Epileptic's tailored version clinical nutrition formula of the present invention includes PURE WHEY 6.7g, soybean protein isolate 3.33g, whole milk powder 11.4g, bovine colostrum 0.17g, ocean fish oligopeptide 0.2g, taurine 0.13g；Olive oil 13g, soybean Oily 21g, coconut oil 13g, perilla herb oil 3g, medium chain triglyceride 1.7g；Maltodextrin 4.58g, rock sugar 2.33g；Aqueous soluble dietary Fiber 5.33g, soybean fiber 3.33g；Calcium 0.53g, phosphorus 0.24g, potassium 0.1g, sodium 0.07g, magnesium 0.174g in macroelement；It is micro- Iron 0.015g, zinc 0.013g in secondary element；Vitamin A 0.0007g, beta carotene 0.017g, vitamin D3 0.000001g、 Vitamin E 0.009g；Vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12 0.000005g, vitamin C 0.163g, pantothenic acid 0.003g, folic acid 0.00013g, niacin 0.0124g；Carrot meal 0.2g, red bean Powder 0.2g, broccoli powder 0.2g, white fungus powder 0.2g, Poria cocos 0.01g, spina date seed 0.01g, peach kernel 0.01g, Chinese yam 0.01g, oyster 0.01g, black pepper 0.01g, γ-aminobutyric acid 0.01g.
Embodiment 2
Epileptic's tailored version clinical nutrition formula of the present invention includes PURE WHEY 6.7g, soybean protein isolate 3.33g, whole milk powder 11.4g, bovine colostrum 0.17g, ocean fish oligopeptide 0.2g, taurine 0.13g；Olive oil 13g, soybean Oily 21g, coconut oil 13g, perilla herb oil 3g, medium chain triglyceride 1.7g；Maltodextrin 4.58g, rock sugar 2.33g；Aqueous soluble dietary Fiber 5.33g, soybean fiber 3.33g；Calcium 0.53g, phosphorus 0.24g, potassium 0.1g, sodium 0.07g, magnesium 0.174g in macroelement；It is micro- Iron 0.015g, zinc 0.013g in secondary element；Vitamin A 0.0007g, beta carotene 0.017g, vitamin D3 0.000001g、 Vitamin E 0.009g；Vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12 0.000005g, vitamin C 0.163g, pantothenic acid 0.003g, folic acid 0.00013g, niacin 0.0124g；Carrot meal 0.2g, red bean Powder 0.2g, broccoli powder 0.2g, white fungus powder 0.2g, Poria cocos 0.2g, spina date seed 0.2g, peach kernel 0.2g, Chinese yam 0.2g, oyster 0.1g, black pepper 0.1g, γ-aminobutyric acid 0.03g.
Embodiment 3
Epileptic's tailored version clinical nutrition formula of the present invention includes PURE WHEY 6.7g, soybean protein isolate 3.33g, whole milk powder 11.4g, bovine colostrum 0.17g, ocean fish oligopeptide 0.2g, taurine 0.13g；Olive oil 10g, soybean Oily 11g, coconut oil 10g, perilla herb oil 1g, medium chain triglyceride 1.7g；Maltodextrin 22.58g, rock sugar 2.33g；Aqueous soluble dietary Fiber 5.33g, soybean fiber 3.33g；Calcium 0.53g, phosphorus 0.24g, potassium 0.1g, sodium 0.07g, magnesium 0.174g in macroelement；It is micro- Iron 0.015g, zinc 0.013g in secondary element；Vitamin A 0.0007g, beta carotene 0.017g, vitamin D3 0.000001g、 Vitamin E 0.009g；Vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12 0.000005g, vitamin C 0.163g, pantothenic acid 0.003g, folic acid 0.00013g, niacin 0.0124g；Carrot meal 0.2g, red bean Powder 0.2g, broccoli powder 0.2g, white fungus powder 0.2g, Poria cocos 0.01g, spina date seed 0.01g, peach kernel 0.01g, Chinese yam 0.01g, oyster 0.01g, black pepper 0.01g, γ-aminobutyric acid 0.01g.
Embodiment 4
The preparation method that a kind of epileptic's tailored version clinical nutrition as described in 1~embodiment of embodiment 3 is matched somebody with somebody is as follows：
1) powdered oil (powder fat) is prepared：
A) wall material aqueous solution is prepared：Take 8 grams of maltodextrin, 4 grams of soybean protein isolate, 11 grams of whole-fat milk powder, dietary fiber 2 Gram (resistant dextrin), 0.5 gram of inulin, 5 grams of PURE WHEY, 0.5 gram of oligoisomaltose, 1 gram of soybean fiber, Arabic gum 0.2 gram, 2 grams of candy sugar powder, 50 milliliters of water stirs evenly and (has ready conditions and heat while stirring to 60 DEG C, keep 30 minutes postcoolings extremely Room temperature).
B) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in (olive oil in 17.38 milliliters of greases monoglyceride 4.4 milliliters, it is 7.2 milliliters of soybean oil, 4.4 milliliters of coconut oil, 1.0 milliliters of perilla herb oil, 0.3 milliliter of medium chain triglyceride, single double sweet 0.08 milliliter of oil and fat acid esters).
C) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in wall material aqueous solution Tween 80.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) addition stabilizer agar takes 0.1 gram (total solid concentration be 0.2%) to be settled into after mixed solution with water 200 milliliters (total solid concentration be 25%), high speed dispersion 2 minutes under 20000r/min.
F) homogenization pressure is 25MPa, and homogeneous emulsion is made in homogeneous 3 times (every time 5 minutes).
G) emulsion obtained is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C.Collect powder Grease (powder fat).
2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, add in weight be raw material weight 3~8 times of water, carry out immersion 3~4 it is small when, then to soak 30~60min of decoction is carried out, filtering removal raw material leaves and takes decoction liquor, decoction liquor is spray-dried, with 60~80 mesh sieves point Prepare integration of drinking and medicinal herbs component powders；
3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core, select carragheen, I Primary glue carries out 2 emulsifying homogeneous processing, the emulsifying homogeneous time is 10~15min, is then sprayed under high pressure as wall material It is instantaneous dry, prepare liposoluble vitamin powder with 60~80 mesh sieves point；Using the water soluble vitamin of predetermined weight number as Core selects maltodextrin, lipoprotein to be uniformly mixed as wall material, spray instantaneous dry, prepared with 60~80 mesh sieves point water-soluble Property vitamin powder；
4) by the protein of predetermined weight and amino acid, nucleotide, carbohydrate, dietary fiber, macroelement, micro Element, meals elite, natural plants compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively；
5) mixer that the powder obtained by step 1)~step 4) is sequentially added to cone-type mixer or other forms mixes Uniformly obtained formula mixture is closed, it is spare after sterilization processing；
6) according to conventional technical means by the formula mixture in step 5) be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral liquid.
In step 6), optionally increase suitable food thickening agent and food additives.The food thickening agent It is described at least one of guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum Food additives are at least one of Aspartame, food flavor fragrance, brown sugar；More preferable carragheen, Arabic gum, Guar Glue, Aspartame, food flavor fragrance.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder explosion.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 5
The present embodiment verifies influence of the nutrient formulation of the present invention to epileptic.The present embodiment uses embodiment 2 Formula prepare electuary and following comparative examples：
Control group 1：Take commercially available antiepileptic (AEDs) -- sodium vedproate piece；
Comparative example 1：It is polyunsaturated fatty acid not add ω -3, the electuary that remaining component is prepared by the formula of embodiment 2；
Comparative example 2：Medium chain triglyceride is not added, the electuary that remaining component is prepared by the formula of embodiment 2；
Comparative example 3：B family vitamin is not added, the electuary that remaining component is prepared by the formula of embodiment 2；
Comparative example 4：Integration of drinking and medicinal herbs ingredient is not added, the electuary that remaining component is prepared by the formula of embodiment 2.
5 groups of experimental group is set, the epileptic 50 for meeting intractable diagnosis of respective tablets is voluntarily taken in every group of selection, High fat diet, test period 12 months are started using " progressively transition high fat diet method ".The experimental results are shown inthe following table：
The comparison (n (%)) of clinical efficacy between the different groups of table 1
It cures：After the test period of 12 months, epileptic attack controls completely, and EEG(electrocardiogram) examination recovers normal；
It is effective：Reduction by 75% or interictal extend before relatively treating before seizure trequency is relatively treated>6 months, electroencephalogram It is obviously improved；
Effectively：Reduction by 50%~75% or breaking-out symptom, which significantly mitigate or break out, before seizure trequency is relatively treated continues Time shortens more than 50%, and electroencephalogram makes moderate progress；
It is invalid：Seizure trequency, severity, cardinal symptom and electroencephalogram improve equal unobvious.
The comparison (n (%)) of adverse reaction rate between the different groups of table 2
As seen from the above table, the electuary prepared in the present invention by the nutrient formulation of embodiment 2 can effectively alleviate epilepsy hair The symptom of work, while Western medicine therapy, the complication of traditional high fat diet therapy are reduced, compared with the control group, comparative example 1-3 also has There is certain effect, but its effect is slightly weaker than nutrient formulation of the present invention.
Specific embodiments of the present invention are described in detail above, but it is intended only as example, it is of the invention and unlimited It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and It substitutes also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and Modification, all should be contained within the scope of the invention.

Claims (9)

1. a kind of epileptic's tailored version clinical nutrition formula, which is characterized in that including following component and its parts by weight：10- 22 parts of protein, 32-55 parts of fat, 6-25 parts of carbohydrate, 7-9 parts of dietary fibers, 0.6-1.2 parts of macroelements, 0.01- 0.04 part of trace element, 0.005-0.03 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamins, 0.05-1 portions of meals Elite, 0.06-2 parts of integration of drinking and medicinal herbs ingredients, 0.1-3 parts of natural plants compounds and 0.005-2 parts of new resource foods；
Wherein, the new resource food be selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, In casein phosphopeptide, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii Tratt, xylo-oligosaccharide at least It is a kind of；
Wherein, the integration of drinking and medicinal herbs ingredient is in Poria cocos, spina date seed, peach kernel, Chinese yam, oyster, black pepper, oyster, Radix Glycyrrhizae It is at least one.
2. a kind of epileptic's tailored version clinical nutrition formula according to claim 1, which is characterized in that the fat is At least one in saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structured lipids, DHA, EPA, ARA, phosphatide Kind.
3. a kind of epileptic's tailored version clinical nutrition formula according to claim 1, which is characterized in that the meals are fine It ties up as inulin, konjaku flour, galactooligosaccharide, oligofructose, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin, big At least one of beans fiber.
4. a kind of epileptic's tailored version clinical nutrition formula according to claim 1, which is characterized in that described fat-soluble Vitamin is vitamin A, beta carotene, vitamine D3, vitamin E, vitamin K1At least one of.
A kind of 5. epileptic's tailored version clinical nutrition formula according to claim 1, which is characterized in that the water solubility Vitamin is vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, pantothenic acid, folic acid, niacin, choline, inositol, At least one of biotin.
A kind of 6. epileptic's tailored version clinical nutrition formula according to claim 1, which is characterized in that the meals essence At least one in Huawei's cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fish and shrimp, poultry meat, fruits Kind.
A kind of 7. epileptic's tailored version clinical nutrition formula according to claim 1, which is characterized in that the new resources Food is γ-aminobutyric acid.
8. a kind of epileptic's tailored version clinical nutrition formula according to claim 1, which is characterized in that the medicine food is same Derived components are Poria cocos, spina date seed, peach kernel, Chinese yam, oyster, black pepper.
It is 9. a kind of such as a kind of preparation side of epileptic's tailored version clinical nutrition formula according to any one of claims 1 to 8 Method, which is characterized in that include the following steps：
Step 1, fat powder, liposoluble vitamin powder and water soluble vitamin powder are prepared using micro-capsule embedding techniques；
Step 2, carried, be spray-dried and sifting step prepares integration of drinking and medicinal herbs component powders using crushing, alcohol extracting, water；
Step 3, by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals elite, Natural plants compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively；
Step 4, powder prepared by step 1~3 is sterilized after mixing spare；
Step 5, the mixed powder of step 4 is prepared by nutrient powder, nutrition emulsion, capsule, piece according to conventional technical means At least one of agent, pill or oral liquid；
Wherein, the order of step 1~3 can be replaced mutually.
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CN109601674A (en) * 2018-12-07 2019-04-12 入圣生物科技无锡有限公司 A kind of adjustable human body body and the food of immunity and preparation method thereof
CN110495606A (en) * 2019-09-18 2019-11-26 金建国 A kind of plant high fat diet formula food
CN111657497A (en) * 2020-06-28 2020-09-15 深圳市捷利康生物科技有限公司 Ketogenic diet for resisting food protein allergy and preparation method thereof
CN112471504A (en) * 2020-12-15 2021-03-12 济南大学 Special medical purpose formula food for epileptic and preparation method thereof
CN112544965A (en) * 2020-12-31 2021-03-26 济南大学 Rose based medical formula food for relieving epilepsy and preparation method thereof
CN113974157A (en) * 2021-09-07 2022-01-28 陕西天承生物科技股份有限公司 A ketogenic diet with homology of medicine and food for relieving adverse reaction

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Application publication date: 20180529