CN107753310A - A kind of gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates and preparation method thereof of new type of safe - Google Patents

A kind of gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates and preparation method thereof of new type of safe Download PDF

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Publication number
CN107753310A
CN107753310A CN201710783691.0A CN201710783691A CN107753310A CN 107753310 A CN107753310 A CN 107753310A CN 201710783691 A CN201710783691 A CN 201710783691A CN 107753310 A CN107753310 A CN 107753310A
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nursing
washing lotion
stimulated
gentle
antibacterial cleaning
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张军
熊伟程
詹结钫
屈虹
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Guangzhou Starriss Chem Tech Ltd
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Guangzhou Starriss Chem Tech Ltd
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Abstract

The invention particularly discloses a kind of gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of new type of safe, described nursing washing lotion match in parts by weight including:5~15% lauryl amphoteric imidazolines, 2~15% APGs, 0.1~5% 20% poly hexamethylene biguanide, 8~20% NMFs, 1~10% skin conditioner, surplus are water and appropriate pH adjusting agent.The three-in-one washing lotion of the gentle non-stimulated antibacterial cleaning-nursing of women privates of safety of the present invention can play a part of quick sterilization, cleaning and nursing simultaneously to women privates, and have no toxic side effect.

Description

A kind of gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of new type of safe And preparation method thereof
Technical field
The present invention relates to women privates cleaning supplies technical field, in particular it relates to which a kind of new type of safe is gently non-stimulated Three-in-one washing lotion of the antibacterial cleaning-nursing of women privates and preparation method thereof.
Background technology
With the quickening pace of modern life, the life stress of people is also increasing, and the thing followed is that species is more and more Disease.For female friend, due to the particularity of its body make-up, so more needing to nurse emphatically.Vagina with it is outer Boundary communicates, and just as an open organ, in an unguarded moment, bacterium will drive straight in.Additionally due to this position it is dark, Humidity, also it is caused to be particularly easy to breed bacteria.
The research and development of Feminine care solution solve the problems, such as because hygienic reason causes related female gynecological disease.Because bacterium is true Bacterium infection causes some gynaecological diseases to need to be cleaned with some special bactericide, and in general nursing washing lotion all simply cleans, It can not sterilize.At present, bactericide mainly has following a few classes:Chloride bactericide, bactericidal effect is good, but not easy to maintain, stimulates greatly, easily Fade;Oxygen-containing bactericide, bactericidal effect is good, unstable, has corrosion to mucocutaneous;Cresols series bactericidal agent, bactericidal effect is general, There is unpleasant taste.Above chemistry series bactericidal agent is used alone, very inconvenient, and not environmentally.Sterilized currently for above-mentioned chemical classes Agent shortcoming and employ high valency silver ion in the female washing and protecting washing lotion researched and developed to sterilize, but the bactericidal effect of silver ion is limited, and And there is no the quantized data of bactericidal effect in Patents.
Therefore the Feminine care lotion developed a kind of gentle quick sterilization of safety and have cleaning-nursing effect concurrently turns into urgent Need.
The content of the invention
The present invention is in order to overcome the above-mentioned deficiency of prior art, there is provided a kind of gentle non-stimulated women privates of new type of safe The antibacterial three-in-one washing lotion of cleaning-nursing, it uses the bactericide of the gentle non-stimulated biguanides of new type of safe, compound gentle both sexes table Bright activating agent and nonionic surfactant and some skin care NMFs, have while safely and fast effectively killing harmful bacteria Effect cleaning privates dirt, suppress bacteria breed, protect privates mucous membrane injury-free, keeping good privates environment.To sterilize/clear Clean/nursing combines together, and sterilizing cleaning nursing settles at one go.
It is a further object to provide a kind of gentle antibacterial cleaning-nursing three of non-stimulated women privates of new type of safe Unify the preparation method of washing lotion.
To achieve these goals, the present invention is achieved by the following technical programs:
A kind of new type of safe gently press by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates, described nursing washing lotion Parts by weight proportioning includes:5~15% lauryl amphoteric imidazolines, 2~15% APGs, the 20% poly- six of 0.1~5% are sub- Methyl biguanides, 8~20% NMFs, 1~10% skin conditioner, surplus are water and appropriate pH adjusting agent.
Preferably, described nursing washing lotion match in parts by weight including:6~12% lauryl amphoteric imidazolines, 3~ 12% APG, 0.1~3% 20% poly hexamethylene biguanide, 10~16% NMFs, 2~8% skin conditioners, surplus are Water and appropriate pH adjusting agent.
It is highly preferred that described nursing washing lotion match in parts by weight including:10% lauryl amphoteric imidazoline, 12% alkane Base glucosides, 1.5% 20% poly hexamethylene biguanide, 10% NMF, 2% skin conditioner, surplus are that water and appropriate pH are adjusted Save agent.
Preferably, the NMF is propane diols or glycerine.
Preferably, the skin conditioner is beta glucan or tremella polysaccharides.
Preferably, the pH adjusting agent is citric acid or tartaric acid.
Preferably, described water is deionized water.
The present invention also provides a kind of system of the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of new type of safe Preparation Method:Comprise the following steps:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, moisturizing in above-mentioned Feminine care lotion formula are sequentially added into Agent, skin conditioner, and stir;
S3. by S2 solution chilling temperature to after 25~30 DEG C, adding pH adjusting agent regulation pH value;
S4. add 20% poly hexamethylene biguanide described in above-mentioned Feminine care lotion formula and some residual go from Sub- water, and stir;
S5. the stoste nylon net filter that will be obtained by S4, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
Preferably, the pH is adjusted between pH 5~5.5.
Preferably, the mesh number of the nylon wire is 400 mesh.
Raw material lauryl amphoteric imidazoline used above, APG, 20% poly hexamethylene biguanide, NMF, skin care The raw material such as agent and water must be weighed accurately, and can not carry ion.
Relative to prior art, beneficial effects of the present invention:
The new type of safe of the present invention gently using biguanides killed by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates Microbial inoculum, there are quick-acting bactericidal actions, to mucocutaneous non-stimulated, stability is good, and commodity can be deposited persistently;Lauryl both sexes imidazoles Quinoline is amphoteric surfactant, as mild as a dove, non-stimulated to skin body, has good washing/dispersed/emulsified performance, bubble The abundant exquisiteness of foam, it is surfactant optimal selection in nursing lotion prescription.
APG is the nonionic surfactant made of natural reproducible plant, and moderate performance, foaming characteristic is good, bubble Foam is abundant fine and smooth stable, good with skin-friendliness, nonirritant, biodegradable, with component lauryl both sexes miaow in the present invention Oxazoline amphoteric surfactant compounds, and complements each other, and foaming abundancy is fine and smooth stable, nonirritant.
The washing lotion of the present invention is up to more than 90% for the sterilizing rate of various bacteriums, especially to staphylococcus aureus and Escherichia coli, its sterilizing rate has reached the physical and chemical index of average adult's shower cream close to 100%, cleaning force, and has passed through toxicity Learn test.In addition, the Feminine care lotion energy lasting stability of the present invention, its normal temperature shelf-life can reach 24 months.
Embodiment
The present invention is made with reference to specific embodiment and further being elaborated, the embodiment is served only for explaining this Invention, is not intended to limit the scope of the present invention.Test method used in following embodiments is normal unless otherwise specified Rule method;Used material, reagent etc., unless otherwise specified, for the reagent and material commercially obtained.
Embodiment 1
A kind of new type of safe gently press by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates, described nursing washing lotion Parts by weight proportioning includes:5~15% lauryl amphoteric imidazolines, 2~15% APGs, the 20% poly- six of 0.1~5% are sub- Methyl biguanides, 8~20% NMFs, 1~10% skin conditioner, surplus are water and appropriate pH adjusting agent.
A kind of preparation method of the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety is:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, moisturizing in above-mentioned Feminine care lotion formula are sequentially added into Agent, skin conditioner, and stir;
S3. by S2 solution chilling temperature to after 25~30 DEG C, adding pH adjusting agent regulation pH value;
S4. add 20% poly hexamethylene biguanide described in above-mentioned Feminine care lotion formula and some residual go from Sub- water, and stir;
S5. the stoste nylon net filter that will be obtained by S4, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
Embodiment 2
A kind of new type of safe gently wrap by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates, in parts by weight proportioning Include:15% lauryl amphoteric imidazoline, 10% APG, 1% 20% poly hexamethylene biguanide, 8% NMF, 1% shield Skin agent, surplus are water, pH adjusting agent.
The Feminine care lotion preparation process of above-mentioned formula is:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, moisturizing in above-mentioned Feminine care lotion formula are sequentially added into Agent, skin conditioner, and stir;
S3. S2 solution chilling temperature to addition pH adjusting agent after 25~30 DEG C is adjusted into pH value to 5~5.5;
S4. add 20% poly hexamethylene biguanide described in above-mentioned Feminine care lotion formula and some residual go from Sub- water, and stir;
S5. by by the stoste that S4 is obtained 400 mesh nylon net filters, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
After testing, the bacteriostasis property of Feminine care lotion that prepared by the embodiment, product toxicological experiment and clear Clean power experiment meets concerned countries or professional standard.
Specific detection content and information are as follows:
The nursing washing lotion that the present embodiment provides, through Guangzhou disease control prevention and control Spot detection, bacteriostasis property reaches《Sterilization Technical specification》The requirement of (2003 editions), fungistatic effect is obvious, meets laws and regulations requirement.Take stoste 1:1 sterilized water test result As shown in table 1:
Table 1
The sterilizing rate significant effect for the nursing washing lotion that the present embodiment provides:After inoculating strain three minutes, it is to golden yellow The killing rate of staphylococcus and Escherichia coli has reached 94%, has also reached 90% to the killing rate of Candida albicans;Inoculation 10 After minute, its killing rate to staphylococcus aureus and Escherichia coli is up to 99.9%, and the killing rate of Candida albicans is reached To 94%.
The submitted sample for the nursing washing lotion that the present embodiment provides carries out chmice acute mouth toxicity test and (once tried to greatest extent Test):Female, male mice LD505000mg/kgBW is all higher than, testing result is nontoxic.
The submitted sample for the nursing washing lotion that the present embodiment provides, cleaning force reach average adult's shower cream (QB 1994- 2013《Bath agent》) as defined in corresponding physical and chemical index.
Embodiment 3
A kind of new type of safe gently wrap by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates, in parts by weight proportioning Include:10% lauryl amphoteric imidazoline, 12% APG, 1.5% 20% poly hexamethylene biguanide, 10% NMF, 2% Skin conditioner, surplus are water, pH adjusting agent.
The Feminine care lotion preparation process of above-mentioned formula is:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, moisturizing in above-mentioned Feminine care lotion formula are sequentially added into Agent, skin conditioner, and stir;
S3. S2 solution chilling temperature to addition pH adjusting agent after 25~30 DEG C is adjusted into pH value to 5~5.5;
S4. add 20% poly hexamethylene biguanide described in above-mentioned Feminine care lotion formula and some residual go from Sub- water, and stir;
S5. by by the stoste that S4 is obtained 400 mesh nylon net filters, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
After testing, the bacteriostasis property of Feminine care lotion that prepared by the embodiment, product toxicological experiment and clear Clean power experiment meets concerned countries or professional standard.
Specific detection content and information are as follows:
The nursing washing lotion that the present embodiment provides, through Guangzhou disease control prevention and control Spot detection, bacteriostasis property reaches《Sterilization Technical specification》The requirement of (2003 editions), fungistatic effect is obvious, meets laws and regulations requirement.Take stoste 1:1 sterilized water test result Such as table 2:
Table 2
The sterilizing rate significant effect for the nursing washing lotion that the present embodiment provides:After inoculating strain three minutes, it is to golden yellow The killing rate of staphylococcus and Escherichia coli has reached 97%, has also reached 92% to the killing rate of Candida albicans;Inoculation 10 After minute, it, close to 100%, reaches to the killing rate of staphylococcus aureus and Escherichia coli to the killing rate of Candida albicans 95%.
The submitted sample for the nursing washing lotion that the present embodiment provides carries out chmice acute mouth toxicity test and (once tried to greatest extent Test):Female, male mice LD505000mg/kgBW is all higher than, testing result is nontoxic.
The submitted sample for the nursing washing lotion that the present embodiment provides, cleaning force reach average adult's shower cream (QB 1994- 2013《Bath agent》) as defined in corresponding physical and chemical index.
Embodiment 4
A kind of new type of safe gently wrap by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates, in parts by weight proportioning Include:8% lauryl amphoteric imidazoline, 15% APG, 2% 20% poly hexamethylene biguanide, 10% NMF, 2% shield Skin agent, surplus are water, pH adjusting agent.
The Feminine care lotion preparation process of above-mentioned formula is:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, moisturizing in above-mentioned Feminine care lotion formula are sequentially added into Agent, skin conditioner, and stir;
S3. S2 solution chilling temperature to addition pH adjusting agent after 25~30 DEG C is adjusted into pH value to 5~5.5;
S4. add 20% poly hexamethylene biguanide described in above-mentioned Feminine care lotion formula and some residual go from Sub- water, and stir;
S5. by by the stoste that S4 is obtained 400 mesh nylon net filters, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
After testing, the bacteriostasis property of Feminine care lotion that prepared by the embodiment, product toxicological experiment and clear Clean power experiment meets concerned countries or professional standard.
Specific detection content and information are as follows:
The nursing washing lotion that the present embodiment provides, through Guangzhou disease control prevention and control Spot detection, bacteriostasis property reaches《Sterilization Technical specification》The requirement of (2003 editions), fungistatic effect is obvious, meets laws and regulations requirement.Take stoste 1:1 sterilized water test result As shown in table 3:
Table 3
The sterilizing rate significant effect for the nursing washing lotion that the present embodiment provides:After inoculating strain three minutes, it is to golden yellow The killing rate of staphylococcus and Escherichia coli has just reached 99%, and the killing rate to Candida albicans is 94%;Inoculation 5 minutes Afterwards, it reaches to the killing rate of staphylococcus aureus and Escherichia coli close to 100% to the killing rate of Candida albicans 96%.
The submitted sample for the nursing washing lotion that the present embodiment provides carries out chmice acute mouth toxicity test and (once tried to greatest extent Test):Female, male mice LD505000mg/kgBW is all higher than, testing result is nontoxic.
The submitted sample for the nursing washing lotion that the present embodiment provides, cleaning force reach average adult's shower cream (QB 1994- 2013《Bath agent》) as defined in corresponding physical and chemical index.
Embodiment 5
The nursing washing lotion prepared according to the formula of the present invention, the product for three lot numbers of sampling, is periodically sampled detection, examines Survey cycle from November 1,1 day to 2016 June in 2014, detection is according to being (cosmetics health specification 2015), respectively to product The index such as outward appearance, smell, pH value, total number of bacteria, coliform and mould detected, the requirement of each index is as shown in table 4, Detecting the lot number that keeps sample includes 2014060101,2014060102 and 2014060103;Its corresponding testing result such as table 5-7 institutes Show:
Table 4
Testing index Standard requirement Test basis
Outward appearance Without layering without precipitation Cosmetics health specification 2015
Smell Characteristic odor Cosmetics health specification 2015
PH value 5-5.5 Cosmetics health specification 2015
Total number of bacteria < 500CFU/ML Cosmetics health specification 2015
Coliform It must not detect Cosmetics health specification 2015
Mould < 10CFU/ML Cosmetics health specification 2015
Keep sample lot number 2014060101 examining report it is as shown in table 5:
Table 5
Keep sample the examining report such as table 6 of lot number 2014060102:
Table 6
Keep sample lot number 2014060103 examining report it is as shown in table 7:
Table 7
Summary analysis 5-7 testing result, testing result show from 0 to 29 month, each Testing index of three batches Meet the related request of cosmetics health specification 2015, thus the present invention product shelf-life be set to 24 months be reasonable 's.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than the present invention is protected The limitation of scope is protected, although being explained with reference to preferred embodiment to the present invention, one of ordinary skill in the art should Work as understanding, technical scheme can be modified or equivalent substitution, without departing from the reality of technical solution of the present invention Matter and scope.

Claims (10)

1. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of a kind of new type of safe, it is characterised in that described Nursing washing lotion match in parts by weight including:5~15% lauryl amphoteric imidazolines, 2~15% APGs, 0.1~5% 20% poly hexamethylene biguanide, 8~20% NMFs, 1~10% skin conditioner, surplus are water and appropriate pH adjusting agent.
2. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 1, its feature Be, described nursing washing lotion match in parts by weight including:6~12% lauryl amphoteric imidazolines, 3~12% alkyl sugar Glycosides, 0.1~3% 20% poly hexamethylene biguanide, 10~16% NMFs, 2~8% skin conditioners, surplus is for water and in right amount PH adjusting agent.
3. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 2, its feature Be, described nursing washing lotion match in parts by weight including:10% lauryl amphoteric imidazoline, 12% APG, 1.5% 20% poly hexamethylene biguanide, 10% NMF, 2% skin conditioner, surplus is water and appropriate pH adjusting agent.
4. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 3, its feature It is, the NMF is propane diols or glycerine.
5. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 3, its feature It is, the skin conditioner is beta glucan or tremella polysaccharides.
6. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 3, its feature It is, the pH adjusting agent is citric acid or tartaric acid.
7. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 3, its feature It is, described water is deionized water.
8. a kind of safety described in any one of claim 1 to 7 is gentle, the non-stimulated antibacterial cleaning-nursing of women privates is three-in-one washes The preparation method of liquid, it is characterised in that comprise the following steps:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, NMF, shield in above-mentioned Feminine care lotion formula are sequentially added into Skin agent, and stir;
S3. by S2 solution chilling temperature to after 25~30 DEG C, adding pH adjusting agent regulation pH value;
S4. the deionization of 20% poly hexamethylene biguanide and some residual described in above-mentioned Feminine care lotion formula is added Water, and stir;
S5. the stoste nylon net filter that will be obtained by S4, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
9. the preparation side of the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 8 Method, it is characterised in that the pH is adjusted between pH 5~5.5.
10. the preparation of the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 9 Method, it is characterised in that the mesh number of the nylon wire is 400 mesh.
CN201710783691.0A 2017-09-04 2017-09-04 A kind of gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates and preparation method thereof of new type of safe Pending CN107753310A (en)

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CN109303742A (en) * 2018-11-12 2019-02-05 成都润兴消毒药业有限公司 A kind of antibacterial conditioning liquid and preparation method thereof
CN109431984A (en) * 2018-12-12 2019-03-08 上海美哈医药科技有限公司 A kind of female private part is dispelled the preparation method of the sliding massage liquid of black silk
CN109674671A (en) * 2019-01-07 2019-04-26 广州市拓瑞科技有限公司 The preparation method of vaginal care composition object and its application and the women secret conditioning liquid comprising it and women secret conditioning liquid
CN110042005A (en) * 2019-05-08 2019-07-23 山东大学 A kind of rush foam system and preparation method thereof for improving alkyl glycosides foaming properties based on the different poly- polysaccharide of tremella
CN112245450A (en) * 2020-10-21 2021-01-22 河北泽丰科技有限公司 Alkalescent cleaning disinfectant and preparation method thereof

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CN101829041A (en) * 2010-04-30 2010-09-15 北京欧凯纳斯科技有限公司 Sterilizing and itch-relieving gynaecological lotion
CN103118655A (en) * 2010-09-22 2013-05-22 艺康美国股份有限公司 Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN101829041A (en) * 2010-04-30 2010-09-15 北京欧凯纳斯科技有限公司 Sterilizing and itch-relieving gynaecological lotion
CN103118655A (en) * 2010-09-22 2013-05-22 艺康美国股份有限公司 Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109303742A (en) * 2018-11-12 2019-02-05 成都润兴消毒药业有限公司 A kind of antibacterial conditioning liquid and preparation method thereof
CN109431984A (en) * 2018-12-12 2019-03-08 上海美哈医药科技有限公司 A kind of female private part is dispelled the preparation method of the sliding massage liquid of black silk
CN109674671A (en) * 2019-01-07 2019-04-26 广州市拓瑞科技有限公司 The preparation method of vaginal care composition object and its application and the women secret conditioning liquid comprising it and women secret conditioning liquid
CN110042005A (en) * 2019-05-08 2019-07-23 山东大学 A kind of rush foam system and preparation method thereof for improving alkyl glycosides foaming properties based on the different poly- polysaccharide of tremella
CN112245450A (en) * 2020-10-21 2021-01-22 河北泽丰科技有限公司 Alkalescent cleaning disinfectant and preparation method thereof

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