CN107753310A - A kind of gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates and preparation method thereof of new type of safe - Google Patents
A kind of gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates and preparation method thereof of new type of safe Download PDFInfo
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- CN107753310A CN107753310A CN201710783691.0A CN201710783691A CN107753310A CN 107753310 A CN107753310 A CN 107753310A CN 201710783691 A CN201710783691 A CN 201710783691A CN 107753310 A CN107753310 A CN 107753310A
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Abstract
The invention particularly discloses a kind of gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of new type of safe, described nursing washing lotion match in parts by weight including:5~15% lauryl amphoteric imidazolines, 2~15% APGs, 0.1~5% 20% poly hexamethylene biguanide, 8~20% NMFs, 1~10% skin conditioner, surplus are water and appropriate pH adjusting agent.The three-in-one washing lotion of the gentle non-stimulated antibacterial cleaning-nursing of women privates of safety of the present invention can play a part of quick sterilization, cleaning and nursing simultaneously to women privates, and have no toxic side effect.
Description
Technical field
The present invention relates to women privates cleaning supplies technical field, in particular it relates to which a kind of new type of safe is gently non-stimulated
Three-in-one washing lotion of the antibacterial cleaning-nursing of women privates and preparation method thereof.
Background technology
With the quickening pace of modern life, the life stress of people is also increasing, and the thing followed is that species is more and more
Disease.For female friend, due to the particularity of its body make-up, so more needing to nurse emphatically.Vagina with it is outer
Boundary communicates, and just as an open organ, in an unguarded moment, bacterium will drive straight in.Additionally due to this position it is dark,
Humidity, also it is caused to be particularly easy to breed bacteria.
The research and development of Feminine care solution solve the problems, such as because hygienic reason causes related female gynecological disease.Because bacterium is true
Bacterium infection causes some gynaecological diseases to need to be cleaned with some special bactericide, and in general nursing washing lotion all simply cleans,
It can not sterilize.At present, bactericide mainly has following a few classes:Chloride bactericide, bactericidal effect is good, but not easy to maintain, stimulates greatly, easily
Fade;Oxygen-containing bactericide, bactericidal effect is good, unstable, has corrosion to mucocutaneous;Cresols series bactericidal agent, bactericidal effect is general,
There is unpleasant taste.Above chemistry series bactericidal agent is used alone, very inconvenient, and not environmentally.Sterilized currently for above-mentioned chemical classes
Agent shortcoming and employ high valency silver ion in the female washing and protecting washing lotion researched and developed to sterilize, but the bactericidal effect of silver ion is limited, and
And there is no the quantized data of bactericidal effect in Patents.
Therefore the Feminine care lotion developed a kind of gentle quick sterilization of safety and have cleaning-nursing effect concurrently turns into urgent
Need.
The content of the invention
The present invention is in order to overcome the above-mentioned deficiency of prior art, there is provided a kind of gentle non-stimulated women privates of new type of safe
The antibacterial three-in-one washing lotion of cleaning-nursing, it uses the bactericide of the gentle non-stimulated biguanides of new type of safe, compound gentle both sexes table
Bright activating agent and nonionic surfactant and some skin care NMFs, have while safely and fast effectively killing harmful bacteria
Effect cleaning privates dirt, suppress bacteria breed, protect privates mucous membrane injury-free, keeping good privates environment.To sterilize/clear
Clean/nursing combines together, and sterilizing cleaning nursing settles at one go.
It is a further object to provide a kind of gentle antibacterial cleaning-nursing three of non-stimulated women privates of new type of safe
Unify the preparation method of washing lotion.
To achieve these goals, the present invention is achieved by the following technical programs:
A kind of new type of safe gently press by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates, described nursing washing lotion
Parts by weight proportioning includes:5~15% lauryl amphoteric imidazolines, 2~15% APGs, the 20% poly- six of 0.1~5% are sub-
Methyl biguanides, 8~20% NMFs, 1~10% skin conditioner, surplus are water and appropriate pH adjusting agent.
Preferably, described nursing washing lotion match in parts by weight including:6~12% lauryl amphoteric imidazolines, 3~
12% APG, 0.1~3% 20% poly hexamethylene biguanide, 10~16% NMFs, 2~8% skin conditioners, surplus are
Water and appropriate pH adjusting agent.
It is highly preferred that described nursing washing lotion match in parts by weight including:10% lauryl amphoteric imidazoline, 12% alkane
Base glucosides, 1.5% 20% poly hexamethylene biguanide, 10% NMF, 2% skin conditioner, surplus are that water and appropriate pH are adjusted
Save agent.
Preferably, the NMF is propane diols or glycerine.
Preferably, the skin conditioner is beta glucan or tremella polysaccharides.
Preferably, the pH adjusting agent is citric acid or tartaric acid.
Preferably, described water is deionized water.
The present invention also provides a kind of system of the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of new type of safe
Preparation Method:Comprise the following steps:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, moisturizing in above-mentioned Feminine care lotion formula are sequentially added into
Agent, skin conditioner, and stir;
S3. by S2 solution chilling temperature to after 25~30 DEG C, adding pH adjusting agent regulation pH value;
S4. add 20% poly hexamethylene biguanide described in above-mentioned Feminine care lotion formula and some residual go from
Sub- water, and stir;
S5. the stoste nylon net filter that will be obtained by S4, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
Preferably, the pH is adjusted between pH 5~5.5.
Preferably, the mesh number of the nylon wire is 400 mesh.
Raw material lauryl amphoteric imidazoline used above, APG, 20% poly hexamethylene biguanide, NMF, skin care
The raw material such as agent and water must be weighed accurately, and can not carry ion.
Relative to prior art, beneficial effects of the present invention:
The new type of safe of the present invention gently using biguanides killed by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates
Microbial inoculum, there are quick-acting bactericidal actions, to mucocutaneous non-stimulated, stability is good, and commodity can be deposited persistently;Lauryl both sexes imidazoles
Quinoline is amphoteric surfactant, as mild as a dove, non-stimulated to skin body, has good washing/dispersed/emulsified performance, bubble
The abundant exquisiteness of foam, it is surfactant optimal selection in nursing lotion prescription.
APG is the nonionic surfactant made of natural reproducible plant, and moderate performance, foaming characteristic is good, bubble
Foam is abundant fine and smooth stable, good with skin-friendliness, nonirritant, biodegradable, with component lauryl both sexes miaow in the present invention
Oxazoline amphoteric surfactant compounds, and complements each other, and foaming abundancy is fine and smooth stable, nonirritant.
The washing lotion of the present invention is up to more than 90% for the sterilizing rate of various bacteriums, especially to staphylococcus aureus and
Escherichia coli, its sterilizing rate has reached the physical and chemical index of average adult's shower cream close to 100%, cleaning force, and has passed through toxicity
Learn test.In addition, the Feminine care lotion energy lasting stability of the present invention, its normal temperature shelf-life can reach 24 months.
Embodiment
The present invention is made with reference to specific embodiment and further being elaborated, the embodiment is served only for explaining this
Invention, is not intended to limit the scope of the present invention.Test method used in following embodiments is normal unless otherwise specified
Rule method;Used material, reagent etc., unless otherwise specified, for the reagent and material commercially obtained.
Embodiment 1
A kind of new type of safe gently press by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates, described nursing washing lotion
Parts by weight proportioning includes:5~15% lauryl amphoteric imidazolines, 2~15% APGs, the 20% poly- six of 0.1~5% are sub-
Methyl biguanides, 8~20% NMFs, 1~10% skin conditioner, surplus are water and appropriate pH adjusting agent.
A kind of preparation method of the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety is:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, moisturizing in above-mentioned Feminine care lotion formula are sequentially added into
Agent, skin conditioner, and stir;
S3. by S2 solution chilling temperature to after 25~30 DEG C, adding pH adjusting agent regulation pH value;
S4. add 20% poly hexamethylene biguanide described in above-mentioned Feminine care lotion formula and some residual go from
Sub- water, and stir;
S5. the stoste nylon net filter that will be obtained by S4, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
Embodiment 2
A kind of new type of safe gently wrap by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates, in parts by weight proportioning
Include:15% lauryl amphoteric imidazoline, 10% APG, 1% 20% poly hexamethylene biguanide, 8% NMF, 1% shield
Skin agent, surplus are water, pH adjusting agent.
The Feminine care lotion preparation process of above-mentioned formula is:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, moisturizing in above-mentioned Feminine care lotion formula are sequentially added into
Agent, skin conditioner, and stir;
S3. S2 solution chilling temperature to addition pH adjusting agent after 25~30 DEG C is adjusted into pH value to 5~5.5;
S4. add 20% poly hexamethylene biguanide described in above-mentioned Feminine care lotion formula and some residual go from
Sub- water, and stir;
S5. by by the stoste that S4 is obtained 400 mesh nylon net filters, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
After testing, the bacteriostasis property of Feminine care lotion that prepared by the embodiment, product toxicological experiment and clear
Clean power experiment meets concerned countries or professional standard.
Specific detection content and information are as follows:
The nursing washing lotion that the present embodiment provides, through Guangzhou disease control prevention and control Spot detection, bacteriostasis property reaches《Sterilization
Technical specification》The requirement of (2003 editions), fungistatic effect is obvious, meets laws and regulations requirement.Take stoste 1:1 sterilized water test result
As shown in table 1:
Table 1
The sterilizing rate significant effect for the nursing washing lotion that the present embodiment provides:After inoculating strain three minutes, it is to golden yellow
The killing rate of staphylococcus and Escherichia coli has reached 94%, has also reached 90% to the killing rate of Candida albicans;Inoculation 10
After minute, its killing rate to staphylococcus aureus and Escherichia coli is up to 99.9%, and the killing rate of Candida albicans is reached
To 94%.
The submitted sample for the nursing washing lotion that the present embodiment provides carries out chmice acute mouth toxicity test and (once tried to greatest extent
Test):Female, male mice LD505000mg/kgBW is all higher than, testing result is nontoxic.
The submitted sample for the nursing washing lotion that the present embodiment provides, cleaning force reach average adult's shower cream (QB 1994-
2013《Bath agent》) as defined in corresponding physical and chemical index.
Embodiment 3
A kind of new type of safe gently wrap by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates, in parts by weight proportioning
Include:10% lauryl amphoteric imidazoline, 12% APG, 1.5% 20% poly hexamethylene biguanide, 10% NMF, 2%
Skin conditioner, surplus are water, pH adjusting agent.
The Feminine care lotion preparation process of above-mentioned formula is:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, moisturizing in above-mentioned Feminine care lotion formula are sequentially added into
Agent, skin conditioner, and stir;
S3. S2 solution chilling temperature to addition pH adjusting agent after 25~30 DEG C is adjusted into pH value to 5~5.5;
S4. add 20% poly hexamethylene biguanide described in above-mentioned Feminine care lotion formula and some residual go from
Sub- water, and stir;
S5. by by the stoste that S4 is obtained 400 mesh nylon net filters, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
After testing, the bacteriostasis property of Feminine care lotion that prepared by the embodiment, product toxicological experiment and clear
Clean power experiment meets concerned countries or professional standard.
Specific detection content and information are as follows:
The nursing washing lotion that the present embodiment provides, through Guangzhou disease control prevention and control Spot detection, bacteriostasis property reaches《Sterilization
Technical specification》The requirement of (2003 editions), fungistatic effect is obvious, meets laws and regulations requirement.Take stoste 1:1 sterilized water test result
Such as table 2:
Table 2
The sterilizing rate significant effect for the nursing washing lotion that the present embodiment provides:After inoculating strain three minutes, it is to golden yellow
The killing rate of staphylococcus and Escherichia coli has reached 97%, has also reached 92% to the killing rate of Candida albicans;Inoculation 10
After minute, it, close to 100%, reaches to the killing rate of staphylococcus aureus and Escherichia coli to the killing rate of Candida albicans
95%.
The submitted sample for the nursing washing lotion that the present embodiment provides carries out chmice acute mouth toxicity test and (once tried to greatest extent
Test):Female, male mice LD505000mg/kgBW is all higher than, testing result is nontoxic.
The submitted sample for the nursing washing lotion that the present embodiment provides, cleaning force reach average adult's shower cream (QB 1994-
2013《Bath agent》) as defined in corresponding physical and chemical index.
Embodiment 4
A kind of new type of safe gently wrap by the three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates, in parts by weight proportioning
Include:8% lauryl amphoteric imidazoline, 15% APG, 2% 20% poly hexamethylene biguanide, 10% NMF, 2% shield
Skin agent, surplus are water, pH adjusting agent.
The Feminine care lotion preparation process of above-mentioned formula is:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, moisturizing in above-mentioned Feminine care lotion formula are sequentially added into
Agent, skin conditioner, and stir;
S3. S2 solution chilling temperature to addition pH adjusting agent after 25~30 DEG C is adjusted into pH value to 5~5.5;
S4. add 20% poly hexamethylene biguanide described in above-mentioned Feminine care lotion formula and some residual go from
Sub- water, and stir;
S5. by by the stoste that S4 is obtained 400 mesh nylon net filters, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
After testing, the bacteriostasis property of Feminine care lotion that prepared by the embodiment, product toxicological experiment and clear
Clean power experiment meets concerned countries or professional standard.
Specific detection content and information are as follows:
The nursing washing lotion that the present embodiment provides, through Guangzhou disease control prevention and control Spot detection, bacteriostasis property reaches《Sterilization
Technical specification》The requirement of (2003 editions), fungistatic effect is obvious, meets laws and regulations requirement.Take stoste 1:1 sterilized water test result
As shown in table 3:
Table 3
The sterilizing rate significant effect for the nursing washing lotion that the present embodiment provides:After inoculating strain three minutes, it is to golden yellow
The killing rate of staphylococcus and Escherichia coli has just reached 99%, and the killing rate to Candida albicans is 94%;Inoculation 5 minutes
Afterwards, it reaches to the killing rate of staphylococcus aureus and Escherichia coli close to 100% to the killing rate of Candida albicans
96%.
The submitted sample for the nursing washing lotion that the present embodiment provides carries out chmice acute mouth toxicity test and (once tried to greatest extent
Test):Female, male mice LD505000mg/kgBW is all higher than, testing result is nontoxic.
The submitted sample for the nursing washing lotion that the present embodiment provides, cleaning force reach average adult's shower cream (QB 1994-
2013《Bath agent》) as defined in corresponding physical and chemical index.
Embodiment 5
The nursing washing lotion prepared according to the formula of the present invention, the product for three lot numbers of sampling, is periodically sampled detection, examines
Survey cycle from November 1,1 day to 2016 June in 2014, detection is according to being (cosmetics health specification 2015), respectively to product
The index such as outward appearance, smell, pH value, total number of bacteria, coliform and mould detected, the requirement of each index is as shown in table 4,
Detecting the lot number that keeps sample includes 2014060101,2014060102 and 2014060103;Its corresponding testing result such as table 5-7 institutes
Show:
Table 4
Testing index | Standard requirement | Test basis |
Outward appearance | Without layering without precipitation | Cosmetics health specification 2015 |
Smell | Characteristic odor | Cosmetics health specification 2015 |
PH value | 5-5.5 | Cosmetics health specification 2015 |
Total number of bacteria | < 500CFU/ML | Cosmetics health specification 2015 |
Coliform | It must not detect | Cosmetics health specification 2015 |
Mould | < 10CFU/ML | Cosmetics health specification 2015 |
Keep sample lot number 2014060101 examining report it is as shown in table 5:
Table 5
Keep sample the examining report such as table 6 of lot number 2014060102:
Table 6
Keep sample lot number 2014060103 examining report it is as shown in table 7:
Table 7
Summary analysis 5-7 testing result, testing result show from 0 to 29 month, each Testing index of three batches
Meet the related request of cosmetics health specification 2015, thus the present invention product shelf-life be set to 24 months be reasonable
's.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than the present invention is protected
The limitation of scope is protected, although being explained with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Work as understanding, technical scheme can be modified or equivalent substitution, without departing from the reality of technical solution of the present invention
Matter and scope.
Claims (10)
1. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of a kind of new type of safe, it is characterised in that described
Nursing washing lotion match in parts by weight including:5~15% lauryl amphoteric imidazolines, 2~15% APGs, 0.1~5%
20% poly hexamethylene biguanide, 8~20% NMFs, 1~10% skin conditioner, surplus are water and appropriate pH adjusting agent.
2. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 1, its feature
Be, described nursing washing lotion match in parts by weight including:6~12% lauryl amphoteric imidazolines, 3~12% alkyl sugar
Glycosides, 0.1~3% 20% poly hexamethylene biguanide, 10~16% NMFs, 2~8% skin conditioners, surplus is for water and in right amount
PH adjusting agent.
3. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 2, its feature
Be, described nursing washing lotion match in parts by weight including:10% lauryl amphoteric imidazoline, 12% APG, 1.5%
20% poly hexamethylene biguanide, 10% NMF, 2% skin conditioner, surplus is water and appropriate pH adjusting agent.
4. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 3, its feature
It is, the NMF is propane diols or glycerine.
5. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 3, its feature
It is, the skin conditioner is beta glucan or tremella polysaccharides.
6. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 3, its feature
It is, the pH adjusting agent is citric acid or tartaric acid.
7. the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 3, its feature
It is, described water is deionized water.
8. a kind of safety described in any one of claim 1 to 7 is gentle, the non-stimulated antibacterial cleaning-nursing of women privates is three-in-one washes
The preparation method of liquid, it is characterised in that comprise the following steps:
S1. by 60~70% 50~60 DEG C of deionized water, it is added in material axe;
S2. APG, lauryl amphoteric imidazoline, NMF, shield in above-mentioned Feminine care lotion formula are sequentially added into
Skin agent, and stir;
S3. by S2 solution chilling temperature to after 25~30 DEG C, adding pH adjusting agent regulation pH value;
S4. the deionization of 20% poly hexamethylene biguanide and some residual described in above-mentioned Feminine care lotion formula is added
Water, and stir;
S5. the stoste nylon net filter that will be obtained by S4, stand for standby use;
S6. the nursing washing lotion after above-mentioned material detected, is filling, being labelled, detection vanning.
9. the preparation side of the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 8
Method, it is characterised in that the pH is adjusted between pH 5~5.5.
10. the preparation of the gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates of safety according to claim 9
Method, it is characterised in that the mesh number of the nylon wire is 400 mesh.
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Cited By (5)
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CN109303742A (en) * | 2018-11-12 | 2019-02-05 | 成都润兴消毒药业有限公司 | A kind of antibacterial conditioning liquid and preparation method thereof |
CN109431984A (en) * | 2018-12-12 | 2019-03-08 | 上海美哈医药科技有限公司 | A kind of female private part is dispelled the preparation method of the sliding massage liquid of black silk |
CN109674671A (en) * | 2019-01-07 | 2019-04-26 | 广州市拓瑞科技有限公司 | The preparation method of vaginal care composition object and its application and the women secret conditioning liquid comprising it and women secret conditioning liquid |
CN110042005A (en) * | 2019-05-08 | 2019-07-23 | 山东大学 | A kind of rush foam system and preparation method thereof for improving alkyl glycosides foaming properties based on the different poly- polysaccharide of tremella |
CN112245450A (en) * | 2020-10-21 | 2021-01-22 | 河北泽丰科技有限公司 | Alkalescent cleaning disinfectant and preparation method thereof |
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CN101829041A (en) * | 2010-04-30 | 2010-09-15 | 北京欧凯纳斯科技有限公司 | Sterilizing and itch-relieving gynaecological lotion |
CN103118655A (en) * | 2010-09-22 | 2013-05-22 | 艺康美国股份有限公司 | Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN101829041A (en) * | 2010-04-30 | 2010-09-15 | 北京欧凯纳斯科技有限公司 | Sterilizing and itch-relieving gynaecological lotion |
CN103118655A (en) * | 2010-09-22 | 2013-05-22 | 艺康美国股份有限公司 | Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109303742A (en) * | 2018-11-12 | 2019-02-05 | 成都润兴消毒药业有限公司 | A kind of antibacterial conditioning liquid and preparation method thereof |
CN109431984A (en) * | 2018-12-12 | 2019-03-08 | 上海美哈医药科技有限公司 | A kind of female private part is dispelled the preparation method of the sliding massage liquid of black silk |
CN109674671A (en) * | 2019-01-07 | 2019-04-26 | 广州市拓瑞科技有限公司 | The preparation method of vaginal care composition object and its application and the women secret conditioning liquid comprising it and women secret conditioning liquid |
CN110042005A (en) * | 2019-05-08 | 2019-07-23 | 山东大学 | A kind of rush foam system and preparation method thereof for improving alkyl glycosides foaming properties based on the different poly- polysaccharide of tremella |
CN112245450A (en) * | 2020-10-21 | 2021-01-22 | 河北泽丰科技有限公司 | Alkalescent cleaning disinfectant and preparation method thereof |
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