CN107412847A - A kind of Wound dressing of liquid form and preparation method thereof - Google Patents
A kind of Wound dressing of liquid form and preparation method thereof Download PDFInfo
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- CN107412847A CN107412847A CN201710528840.9A CN201710528840A CN107412847A CN 107412847 A CN107412847 A CN 107412847A CN 201710528840 A CN201710528840 A CN 201710528840A CN 107412847 A CN107412847 A CN 107412847A
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- wound
- wound dressing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention belongs to field of medical products, is related to a kind of Wound dressing of liquid form and preparation method thereof.The raw material of the Wound dressing forms and weight component percentage is：Camphor 0 15%, phenmethylol 0 23%, isopropyl myristate 0 30%, bactericide 0 5%, film forming agent 1 20%, plasticizer 0 20%, surfactant 0 5%, remaining be solvent.Gained liquid dressing of the invention is easy to use, coated on patient skin affected part can rapid film formation, there is preferable toughness, elasticity, soft comfortable, the surface of a wound can be protected, prevent from infecting, promotion Wound healing.Gained liquid dressing of the invention is easy to use, is not limited by wound and present position, and waterproof and breathable, wound are visual.Other preparation technology is simple, and cost is low, is easy to industrialization production.The present invention is applied to incised wound, scratch, lacerated wound, and the processing and nursing of skin other breakages.
Description
Technical field
The invention belongs to field of medical products, is related to a kind of Wound dressing of liquid form and preparation method thereof.
Background technology
Skin is the first layer barrier of body defenses external aggression, and the tissue that body area is maximum.Skin histology
Damage, can not only cause the destruction of hypodermis, can also influence the inner equilibrium of body.In daily life and medical care
In, protect intact skin or damaged skin to exempt from further damage (such as sharp weapon incised wound, burn, scratch) increasingly by big
The concern and attention of family, during wound healing, the use of wound dressing is extremely important for the healing of skin injury, can
The infringement of outside is protected the wound from, includes the superinfection of the microorganism such as the injury of physical contact property and bacterium.
Wound dressing in the market, traditional adhesive bandage still play powerful effect, although with hemostasis by compression,
Protect the surface of a wound, small volume, using it is simple the advantages that.But the adhesive plaster poor air permeability used in it, the normocrinic water of body local institute
Vapour and sweat can not penetrate this layer of adhesive plaster, then produce action of soaking to breakage skin, make wound and the skin of wound circumference
Turn white, softening causes the scabies secondary infection of bacterium so as to aggravate the deterioration of wound.In addition, in wound healing process, granulation tissue
Can slowly be grown to adhesive plaster center, causes adhesive plaster to be closely adhered to each other with cambium, it is difficult to remove, and causes new
The tear of raw tissue, may aggravate wound, increase the pain of patient what is more.In addition, the adhesive plaster of strip is affixed on affected part shadow
Sound is attractive in appearance and irregular in many traumatic wounds, and wound is also not convenient to use at some specific positions.
The content of the invention
In order to solve the above problems, it is an object of the invention to provide a kind of Wound dressing of external use liquid form, can replace
It is used for the processing of skin injury for traditional adhesive bandage.
It is a still further object of the present invention to provide the preparation method of the Wound dressing of aforesaid liquid form.
The purpose of the present invention is realized by following technical proposal：
A kind of Wound dressing of liquid form, its raw material composition and percentage by weight are：
Whole component sums of specific product are 100%.
The Wound dressing of described liquid form, its raw material composition and percentage by weight are：
Whole component sums of specific product are 100%.
The Wound dressing of described any liquid form, wherein：Described solvent be low-acid chain esters, alcohols solvent or
One or more in ether solvent；Wherein low-acid chain esters solvent includes ethyl acetate, n-butyl acetate, Sucrose Acetate
One or more in ester, hexyl acetate, isobutyl isobutyrate, pentyl acetate；Alcohols solvent includes one in ethanol, isopropanol
Kind is several；Ether solvent includes ether.
The Wound dressing of described any liquid form, wherein：Described film forming agent is that cellulosic polymer includes nitre
One or more in acid cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, cellulose acetate.
The Wound dressing of described any liquid form, wherein：Described bactericide is benzethonium chloride, 3,4,4 '-trichlorine
Acardite, benzalkonium bromide, benzalkonium chloride, anesin, ethyl hydroxy benzoate, Nipasol, butyl hydroxybenzoate, methylparoban,
One or more in benzoic acid, sodium benzoate.
The Wound dressing of described any liquid form, wherein：Described plasticizer be glycerine, propane diols, polyethylene glycol,
Cochin oil, castor oil, corn oil, liquid paraffin, monoacetin, triacetin, dibutyl phthalate,
One or more in diethyl phthalate.
The Wound dressing of described any liquid form, wherein：Described surfactant is lauryl sodium sulfate, gathered
One or more in sorb ester, poloxamer, polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether.
The preparation method of the Wound dressing of described any liquid form, this method comprise the following steps：
Each liquid component for weighing recipe quantity is well mixed, and adds the solid constituent of recipe quantity, and stirring makes to be completely dissolved i.e.
.
Further, the preparation method comprises the following steps：First by each in addition to camphor, bactericide, film forming agent of recipe quantity
Liquid component is added in container and is well mixed, and is slowly added to the camphor and bactericide and other solids in addition to film forming agent of recipe quantity
Component, stirring make to be completely dissolved, and are eventually adding the film forming agent of recipe quantity, and stirring, which makes to be completely dissolved, both to be obtained.
The Wound dressing of described any liquid form, the dosage form of the dressing is liquid adhesive bandage, spray, or cotton swab
Form.
Each primary raw material role is as follows in the Wound dressing of above-mentioned liquid form：
The dicyandiamide solution that the present invention selects is readily volatilized under body temperature.Film formed by filmogen has well thoroughly
It is the advantages that bright property, elasticity, pliability, toughness, gas permeability, water proofing property, and good biocompatibility, safe and non-stimulating.Phenmethylol has
There is analgesic and improve film properties effect.Isopropyl myristate is skin lubrication agent, has a moisturizing wound, promote wound healing,
Reduce pain and cicatrization.Bactericide can use benzethonium chloride, 3,4,4 '-neko, benzalkonium bromide, benzene as needed
Prick in oronain, anesin, ethyl hydroxy benzoate, Nipasol, butyl hydroxybenzoate, methylparoban, benzoic acid, sodium benzoate
It is one or more of.Camphor has antipruritic, swelling and pain relieving effect, promotion wound healing.
The color that colouring agent changes preparation can also be properly added, for prompting wound site.
Beneficial effects of the present invention
This product uses the macromolecule raw material of biocompatibility, and for film forming agent, coated on skin affected part, solvent rapid draing is simultaneously
Form ventilative, waterproof and flexible transparent protective film.With every bacterium, good lasting gas permeability and water proofing property, easy to use
The features such as, in addition, institute's film forming is soft, comfortable, it is adapted to the protection of the surface of a wound of any irregular shape, avoids the degree of lip-rounding due to wound well
Shape irregular and cause adhesive plaster adhesive bandage to be difficult to post, paste the shortcomings that firm.The film that the present invention is formed has uniform, transparent
Outward appearance, it is easy to observe wound situation and promotes wound to recover.Moreover, the preparation method of the liquid wound dressing of the invention, production
Technique is simple, and cost is low, environment friendly and pollution-free, is adapted to industrialization.
Liquid wound dressing provided by the present invention is used to hurt, and abrades, lacerated wound, and the processing of skin other breakages
With nursing with unique advantage, one layer of uniform, transparent film can be formed at skin injury.Institute's film forming is soft, comfortable, fits
The protection of the surface of a wound of any irregular shape is closed, while wound healing situation can also be observed, while is had to tissue fluid, sweat class thing
Good absorbability, and there is lasting gas permeability, water proofing property.Therefore, liquid wound dressing provided by the present invention have with
Lower advantage：
1st, this product film forming is fast, and the film soft comfortable formed, good seal performance, can prevent bacterium and foreign matter from invading wound
Mouthful, reduce infection.
2nd, this product has preferable anti-infection ability, sterilization, swelling and pain relieving, promotes wound healing.
3rd, the film that this product is formed has preferable mechanical performance, has the transparency, elasticity, pliability, toughness, is easy to make
User observes the healing state of the surface of a wound and protection to the irregular shape surface of a wound, avoids the irregular of mouth-shaped due to wound and leads
It is difficult to post, paste the shortcomings that firm to cause adhesive plaster adhesive bandage.The film that other this product is formed has lasting gas permeability and water proofing property.The production
Product have excellent histocompatbility, non-stimulated to wound.
4th, after wound tentatively heals, film formed by this product easily removes from wound, will not cause tearing for cambium
Split.
5th, this product can ensure the environment of surface of a wound moistening, avoid the generation of tissue hydrops, be advantageous in wound healing process, carefully
The propagation of born of the same parents and migration.
6th, the aesthetic requirement of user is met.
7th, preparation technology is simple, and cost is low, is easy to industrialization production, and environment friendly and pollution-free.
Specific embodiment
The invention will be further elaborated by the following examples.
Embodiment 1
Liquid dressing of the present invention is prepared in accordance with the following steps
1) raw material is weighed by following components：
2) first each liquid component of recipe quantity is added in reactor, starting reactor agitator makes it well mixed, delays
The slow camphor and benzethonium chloride for adding recipe quantity, stirring make to be completely dissolved, and are eventually adding the nitrocellulose of recipe quantity, stirring makes
It is completely dissolved and both obtained.Filling, finished product is made in sterilizing, packaging.
Embodiment 2
Liquid dressing of the present invention is prepared in accordance with the following steps
1) raw material is weighed by following components：
2) first each liquid component of recipe quantity is added in reaction vessel, stirring makes it well mixed, is slowly added to prescription
The camphor and benzethonium chloride of amount, stirring make to be completely dissolved, and are eventually adding the nitrocellulose of recipe quantity, and stirring makes to be completely dissolved both
.Filling, finished product is made in sterilizing, packaging.
Embodiment 3
Liquid dressing of the present invention is prepared in accordance with the following steps
1) raw material is weighed by following components：
2) first each liquid component of recipe quantity is added in reactor, starting reactor agitator makes it well mixed, delays
The slow camphor and 3 for adding recipe quantity, 4,4 '-neko, stirring makes to be completely dissolved, and is eventually adding the ethyl cellulose of recipe quantity
Element, stirring, which makes to be completely dissolved, both to be obtained.Filling, finished product is made in sterilizing, packaging.
Embodiment 4
Liquid dressing of the present invention is prepared in accordance with the following steps
1) raw material is weighed by following components：
2) first each liquid component of recipe quantity is added in reactor, starting reactor agitator makes it well mixed, delays
The slow camphor and 3 for adding recipe quantity, 4,4 '-neko, stirring makes to be completely dissolved, and the ethoxy for being eventually adding recipe quantity is fine
Dimension element, stirring, which makes to be completely dissolved, both to be obtained.Filling, finished product is made in sterilizing, packaging.
Embodiment 5
Liquid dressing of the present invention is prepared in accordance with the following steps
1) raw material is weighed by following components：
2) first each liquid component of recipe quantity is added in reactor, starting reactor agitator makes it well mixed, delays
The slow camphor and benzethonium chloride for adding recipe quantity, stirring make to be completely dissolved, and are eventually adding the ethyl cellulose and nitric acid of recipe quantity
Cellulose, stirring, which makes to be completely dissolved, both to be obtained.Filling, finished product is made in sterilizing, packaging.
Embodiment 6
Embodiment 1-5 bacteriostatic experiments
Material:Sample prepared by embodiment 1-5；Physiological saline；Culture medium：Nutrient broth medium is by formula (Beijing three
Medicine scientific and technological development company, model 11B01) prepare, regulation pH6.5,1.2% agar of addition, after autoclaving, 45 DEG C of constant temperature water baths
It is standby.Experimental strain：Selection standard strain Escherichia coli ATCC25922, staphylococcus aureus ATCC6538.It is stored in -80
℃.It is prepared by bacteria suspension：The fresh slant strains of each test strain are taken, lower lawn is washed with sterile saline, with Maxwell opacity tube ratio
It is turbid, suitably it is diluted to concentration about 1-9 × 106Cfu/ml is standby.
Bacteriostasis rate determines：Each sample 5mL is taken to be directly added into sterile test tube, every kind of 3 parts of sample preparation respectively：Respectively at each
1 kind of experiment bacteria suspension 0.5mL is added in test tube, it is about 1-9 × 10 to make bacterial concentration5cfu·mL-1, DL instrument mixes, in 25 DEG C
Take 0.5mL to add physiological saline after placement 0,2,10,20min and suitably dilute the counting of rear plate method.Simultaneously using physiological saline as
Control is measured in the same method.
Calculate bacteriostasis rate：Bacteriostasis rate %=(A-B)/A × 100%
A：Physiological saline negative control count results
B：Sample count result
Embodiment 1-5 bacteriostasis rates are as shown in table 1：
The embodiment 1-5 bacteriostasis rates of table 1.
Claims (10)
- A kind of 1. Wound dressing of liquid form, it is characterised in that：Raw material forms and percentage by weight is：
- 2. the Wound dressing of liquid form according to claim 1, it is characterised in that：Raw material forms and percentage by weight For：
- 3. the Wound dressing of any liquid form according to claim 1-2, it is characterised in that：Described solvent is low chain One or more in alkanoic acid esters, alcohols solvent or ether solvent；Wherein low-acid chain esters solvent includes ethyl acetate, second One or more in sour N-butyl, isobutyl acetate, hexyl acetate, isobutyl isobutyrate, pentyl acetate；Alcohols solvent includes One or more in ethanol, isopropanol；Ether solvent includes ether.
- 4. the Wound dressing of any liquid form according to claim 1-2, it is characterised in that：Described film forming agent is fibre Dimension element birdss of the same feather flock together compound including in nitrocellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, cellulose acetate One or more.
- 5. the Wound dressing of any liquid form according to claim 1-2, it is characterised in that：Described bactericide is benzyl Rope oronain, 3,4,4 '-neko, benzalkonium bromide, benzalkonium chloride, anesin, ethyl hydroxy benzoate, Nipasol, oxybenzene One or more in butyl ester, methylparoban, benzoic acid, sodium benzoate.
- 6. the Wound dressing of any liquid form according to claim 1-2, it is characterised in that：Described plasticizer is sweet Oil, propane diols, polyethylene glycol, cochin oil, castor oil, corn oil, liquid paraffin, monoacetin, TG acid One or more in ester, dibutyl phthalate, diethyl phthalate.
- 7. the Wound dressing of any liquid form according to claim 1-2, it is characterised in that：Described surfactant For one kind in lauryl sodium sulfate, polysorbate, poloxamer, polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether It is or several.
- 8. the preparation method of the Wound dressing of any liquid form described in claim 1-2, it is characterised in that this method includes The following steps：Each liquid component for weighing recipe quantity is well mixed, and adds the solid constituent of recipe quantity, and stirring, which makes to be completely dissolved, to be produced.
- 9. the preparation method of the Wound dressing of any liquid form according to claim 1-2, it is characterised in that this method Comprise the following steps：First each liquid component in addition to camphor, bactericide, film forming agent of recipe quantity is added in container and is well mixed, is slowly added to The camphor and bactericide of recipe quantity and other solid constituents in addition to film forming agent, stirring make to be completely dissolved, and are eventually adding recipe quantity Film forming agent, stirring makes to be completely dissolved both.
- 10. the Wound dressing of any liquid form according to claim 1-2, it is characterised in that the dosage form of the dressing It is liquid adhesive bandage, spray, or cotton swab form.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710528840.9A CN107412847A (en) | 2017-07-01 | 2017-07-01 | A kind of Wound dressing of liquid form and preparation method thereof |
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| CN201710528840.9A CN107412847A (en) | 2017-07-01 | 2017-07-01 | A kind of Wound dressing of liquid form and preparation method thereof |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210991A (en) * | 2018-01-16 | 2018-06-29 | 宜春学院 | A kind of silicon substrate induced activity liquid dressing and preparation method thereof |
| CN108671264A (en) * | 2018-07-23 | 2018-10-19 | 衢州玛济克医疗科技有限公司 | A kind of body surface wound hemostasis liquid dressing and its production method |
| CN108744027A (en) * | 2018-07-04 | 2018-11-06 | 长春工业大学 | A kind of protein-based liquid adhesive bandage and preparation method thereof |
| CN108785739A (en) * | 2018-08-13 | 2018-11-13 | 中国人民解放军南京军区福州总医院 | A kind of full-service fluid adhesive bandage and preparation method thereof |
| CN108837175A (en) * | 2018-07-23 | 2018-11-20 | 衢州玛济克医疗科技有限公司 | A kind of debridement medical dressing and its production method |
| CN108904859A (en) * | 2018-07-23 | 2018-11-30 | 衢州玛济克医疗科技有限公司 | A kind of hemorrhoid medical dressing and its production method |
| CN108904876A (en) * | 2018-10-15 | 2018-11-30 | 长春艾迪尔医用科技发展有限公司 | A kind of liquid wound dressing and preparation method thereof |
| CN108992704A (en) * | 2018-08-20 | 2018-12-14 | 丹东欣时代生物医药科技有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN109289084A (en) * | 2018-10-30 | 2019-02-01 | 河南汇博医疗股份有限公司 | A kind of surface of a wound antibacterial liquid dressing and preparation method thereof |
| CN110898092A (en) * | 2019-11-25 | 2020-03-24 | 上海强德食品科技有限公司 | Liquid hemostatic and detumescence patch composition and preparation method thereof |
| CN111195369A (en) * | 2020-01-20 | 2020-05-26 | 蓝佳堂生物医药（福建）有限公司 | Preparation method of waterproof liquid wound dressing |
| CN113679879A (en) * | 2021-08-20 | 2021-11-23 | 广东粤港澳大湾区黄埔材料研究院 | Liquid skin and preparation method and application thereof |
| CN114306729A (en) * | 2022-03-15 | 2022-04-12 | 中国人民解放军总医院第一医学中心 | Biological antibacterial film-forming liquid medical dressing and preparation method thereof |
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| CN106075557A (en) * | 2016-06-24 | 2016-11-09 | 青岛中腾生物技术有限公司 | A kind of liquid wound protection material formed containing nanoaperture flexible membrane |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075557A (en) * | 2016-06-24 | 2016-11-09 | 青岛中腾生物技术有限公司 | A kind of liquid wound protection material formed containing nanoaperture flexible membrane |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210991A (en) * | 2018-01-16 | 2018-06-29 | 宜春学院 | A kind of silicon substrate induced activity liquid dressing and preparation method thereof |
| CN108744027A (en) * | 2018-07-04 | 2018-11-06 | 长春工业大学 | A kind of protein-based liquid adhesive bandage and preparation method thereof |
| CN108671264A (en) * | 2018-07-23 | 2018-10-19 | 衢州玛济克医疗科技有限公司 | A kind of body surface wound hemostasis liquid dressing and its production method |
| CN108837175A (en) * | 2018-07-23 | 2018-11-20 | 衢州玛济克医疗科技有限公司 | A kind of debridement medical dressing and its production method |
| CN108904859A (en) * | 2018-07-23 | 2018-11-30 | 衢州玛济克医疗科技有限公司 | A kind of hemorrhoid medical dressing and its production method |
| CN108785739A (en) * | 2018-08-13 | 2018-11-13 | 中国人民解放军南京军区福州总医院 | A kind of full-service fluid adhesive bandage and preparation method thereof |
| CN108992704A (en) * | 2018-08-20 | 2018-12-14 | 丹东欣时代生物医药科技有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN108904876A (en) * | 2018-10-15 | 2018-11-30 | 长春艾迪尔医用科技发展有限公司 | A kind of liquid wound dressing and preparation method thereof |
| CN109289084A (en) * | 2018-10-30 | 2019-02-01 | 河南汇博医疗股份有限公司 | A kind of surface of a wound antibacterial liquid dressing and preparation method thereof |
| CN110898092A (en) * | 2019-11-25 | 2020-03-24 | 上海强德食品科技有限公司 | Liquid hemostatic and detumescence patch composition and preparation method thereof |
| CN111195369A (en) * | 2020-01-20 | 2020-05-26 | 蓝佳堂生物医药（福建）有限公司 | Preparation method of waterproof liquid wound dressing |
| CN113679879A (en) * | 2021-08-20 | 2021-11-23 | 广东粤港澳大湾区黄埔材料研究院 | Liquid skin and preparation method and application thereof |
| CN114306729A (en) * | 2022-03-15 | 2022-04-12 | 中国人民解放军总医院第一医学中心 | Biological antibacterial film-forming liquid medical dressing and preparation method thereof |
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Application publication date: 20171201 |