CN107233494A - A kind of Chinese medicine preparation for being used to adjust sleep function - Google Patents

Abstract

The present invention relates to the field of Chinese medicines, more particularly to a kind of Chinese medicine preparation for being used to adjust sleep function.It is made up of the raw material of following parts by weight：5 15 parts of spina date seed, 5 15 parts of polygala, 5 15 parts of the fruit of Chinese magnoliavine, 5 15 parts of wilsonii, 5 15 parts of arillus longan, 5 15 parts of Poria cocos, 5 15 parts of sealwort, 5 15 parts of radix polygonati officinalis, 5 15 parts of barrenwort.The traditional Chinese medicine composite is few, with low cost, and toxic side effect is small, practical, can effectively adjust insomnia.

Description

A kind of Chinese medicine preparation for being used to adjust sleep function

Technical field

The present invention relates to the field of Chinese medicines, more particularly to a kind of Chinese medicine preparation for being used to adjust sleep function.

Background technology

Insomnia, the traditional Chinese medical science referred to as " is insomnia ", is often referred to patient and the length of one's sleep or quality are unsatisfactory for and influence social in the daytime A kind of subjective experience of function.The summation of people's length of one's sleep in all one's life accounts for 1/3rd of whole life, as modern society gives birth to Movable joint, which is played, to be speeded, and the life stress increasingly aggravated causes increasing people irregular daily life, abnormal feeling fluctuation, nerve occur How disorderly, because of the difference on individual physique, there is different types of insomnia in final development, while other diseases can be aggravated for the secretion of mediator Disease induces original seizure of disease.

Statistics shows that whole world insomnia investigation display in 2002, China insomniac accounts for the 45.4% of general population, height In the insomnia incidence of developed countries.However, sleep quality can influence physiological health, animation and the society of individual Relation is harmonious, and anxiety, anxiety, the individual character of irritability can induce and aggravate insomnia.Although insomnia is without very high fatal rate, Very big pain can be brought to individual, thus insomnia problem should be paid much attention to by society.

《Doctor's effect, which must not secretly hand down, sleeps》It is middle to discuss：" night, cloudy gas was closed and reposal into then mesh based on the moon, if the deficiency of Yin is positive institute Victory, then bother and egersis all the night.Then yang-energy is empty after heart storing spirit, profuse sweating, therefore egersis.The main blood of the heart, it is big lower after then gas it is weak, therefore not Sleep ".Point out that the awake of people is slept, by mind control, and the normal operation that battalion defends negative and positive is to ensure the basis that mind awake is slept.

Though the traditional Chinese medical science thinks that the cause of disease of insomnia is more, men outnumbered women for total category, imbalance of yin and yang.One is that the deficiency of Yin does not receive sun, and one is sun Must not contain and enter the moon.Its sick position is main in the heart, closely related with liver,spleen,kidney.Because The heart controls mental activities, Shen Anze sleeps, and god is uneasy then not Sleep.And the source of yang blood and qi, by foodstuff essence micro-ization, above give in the heart, then the mind must be supported；Liver is hidden in, then liver body is soft； Have under one's command in spleen, then biochemistry does not stop；Adjust degree of having, change and be essence, be built in kidney, kidney essense and hold in meeting at kidney under the heart, the motive, then it is refreshing Will is peaceful.

At present, the medicine positioning for treatment insomnia is mainly focused on the symptom of relieving insomnia and makes sleeping for insomniac Dormancy situation obtains basic improve in terms of two.Western medicine can effectively relieving insomnia symptom, but side effect is also larger, such as chloraldurate It is to develop a kind of hypnotic earlier, it is comparatively relatively safer, it can be fallen asleep after medication, without sense of discomfort after waking up, but it is most normal The side effect seen is gastrointestinal irritation, especially peptic ulcer and gastroenteritis patient, must use with caution or disable, and is used for a long time Chloraldurate can cause additive and tolerance；Barbiturates are the sleeping medicines of twenty beginning of the century exploitation listing, due to its use The after effect such as dizzy, sleepy is may occur in which after medicine, causes patient to produce and looks forward or upwards absurd and epilepsy seizure, long use can have it is additive with And excessive use has ill-effect etc.；Stable is clinically the most frequently used somnifacient at present, belongs to long-acting drug, especially to anxious insomnia Curative effect is splendid；Compared with barbiturates somnifacient, it has therapeutic index high, small, several to fast wave sleep (REM) on breathing influence Without influence, the features such as on liver drug enzyme without influence, but it is stable can cause drowsiness, slight headache, weak, ataxia, gerontal patient is more Reacted more than easily occurring, patient requests in most cases use with caution；It is nearly all that there is soporific function Western medicine to have side effect, and It is mostly prescription medicine, common insomniac is difficult to obtain, even if can normally take, these Western medicine are also only capable of relieving insomnia symptom. And Chinese medicine can not only alleviate sleep symptom, it can also improve sleep state, and Small side effects.Therefore, tcm field is for insomnia Notable, the with strong points Chinese medicine preparation for being used to adjust sleep function of the further research effect of the interpretation of the cause, onset and process of an illness, it appears particularly important.

The content of the invention

In view of the above-mentioned problems, be used to adjust the Chinese medicine preparation of sleep function it is an object of the invention to provide a kind of, in this Drug composition raw material is few, with low cost, and toxic side effect is small, practical, and can effectively adjust insomnia.

To achieve these goals, it is by following parts by weight provided by the present invention for the Chinese medicine preparation for the treatment of sleep Raw material composition：5-15 parts of spina date seed, 5-15 parts of polygala, 5-15 parts of the fruit of Chinese magnoliavine, 5-15 parts of wilsonii, 5-15 parts of arillus longan, Fu 5-15 parts of Siberian cocklebur, 5-15 parts of sealwort, 5-15 parts of radix polygonati officinalis, 5-15 parts of barrenwort.

To achieve these goals, provided by the present invention for the preparation method for the Chinese medicine preparation for adjusting sleep function, bag Include following steps.

Step 1, pretreatment：Material is got with production ordering and checks material code name, the name of an article, specification, numbering and weight etc., And carry out removing coat and sterilization.

Step 2, granulation：Spina date seed, polygala, the fruit of Chinese magnoliavine, wilsonii, arillus longan, Poria cocos, sealwort, jade are taken by formula rate Bamboo and barrenwort；Ethanol is reclaimed after alcohol extracting, extraction, the place of letting cool is moved after concentration and is stood, makes precipitation completely, filtering, filtrate low temperature is dense It is reduced to thick medicinal extract, dry dextrin, Icing Sugar are put in appropriate containers, are added thick medicinal extract and are stirred, wet granular is made；Dextrin, Icing Sugar and thick medicinal extract（1.35,50 DEG C）Ratio is 3：1：1, can suitably it be adjusted according to the proportion of thick medicinal extract, property and medication purpose, Dry particl water content≤6.0% should be controlled.

Step 3, drying：After granulation, processing is dried.

Step 4, whole grain：Dried material is handled in pelletizing machine.

Step 5, mixing filling：By the material after step 4 whole grain, addition lactose, amylum pregelatinisatum, superfine silica gel powder, sorb Alcohol or PVPk3 etc. clinically after pharmaceutically acceptable auxiliary material, are well mixed in mixer, and required formulation, Ran Hou is made Packed on automatic packaging machine.

Step 6, thermal contraction：Ready-made inner wrapping product is accomplished fluently into the corresponding date of manufacture, heat shrink films is packaged and carries out hot receipts Contracting.

Step 7, metal detection：Product after thermal contraction is placed on food metal detector and detected, is then packed Packing, obtains finished product.

Step 8, storage：Finished product is put into the qualified area of product of storehouse.

It is various required that the Chinese medicine preparation for adjusting sleep function can be made into Chinese herbal medicine powder, the water-bindered pill or honeyed bolus etc. Formulation.

Property of medicine analysis of each component in prescription.

Spina date seed（Fry）：Sweet, acid, puts down；Return liver, courage, the heart channel of Hang-Shaoyin；Nourishing heart tonifying liver, antitoxic heart-soothing and sedative, arrest sweating promotes the production of body fluid；For dysphoria Egersis, horrified to much dream, body void hidrosis, injury thirst.

Polygala：Bitter, pungent, temperature；The thoughts of returning home, kidney, lung channel；Tranquilize the mind and promote the intelligence, eliminating the phlegm, Xie Yu；Palpitation with fear is controlled, forgetful, nocturnal emission is had a sleepless night, Cough ant phlegm, ulcer sore swells；Coma phlegm for phlegmatic mental confusion is contained and insane and breakdown of the normal physiological coordination between the heart and the kidney insomnia.

The fruit of Chinese magnoliavine：It is sour, sweet, temperature；Return lung, the heart, kidney channel；With nourshing kidney of astringing the lung, the arrest sweating that promotes the production of body fluid, puckery smart antidiarrheal, antitoxic heart-soothing and sedative Effect；Breathed heavily for void of coughing long, it is emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, interior The diseases such as heat is quenched one's thirst, palpitation and insomnia.

Wilsonii：It is pungent, bitter, micro-sweet, warm-natured；Return liver warp, kidney channel；With wind-damp dispelling, filling liver kidney, strengthening the bones and muscles, promoting blood circulation arteries and veins；With In wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, the retardation of walking of decimal a little, physically weak frail, traumatic injury, fracture, oedema, tinea pedis, the moon Under wet itch.

Arillus longan：It is sweet, warm-natured；The thoughts of returning home, the spleen channel；Effect tonifying heart and spleen, nourishing blood and tranquilization；For insufficiency of vital energy and blood, palpitaition is seized with terror It is sad, forgetful insomnia, blood deficiency chlorosis.

Sealwort：It is sweet, put down；Returns spleen, lung, kidney channel；Boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing；For deficiency of spleen-QI and stomach-QI, body is tired weary Power, deficiency of stomach-Yin, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis, Heat Diabetes.

Radix polygonati officinalis：It is sweet, it is slightly cold；Attach to the lung and stomach meridians；Nourishing yin to moisten dryness, promotes the production of body fluid to quench thirst；For lung stomach impairment of yin, cough caused by dryness-heat, dry throat mouthful Yearningly, Heat Diabetes.

Poria cocos：It is sweet, light, flat；The thoughts of returning home, lung, the spleen channel；With eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative；For Difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, vomiting during early pregnancy, diarrhea, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful to wait disease.

Barrenwort：Acrid, sweet, warm；Return liver and kidney channel；Tonifying kidney and strengthening yang, dispelling wind and eliminating dampness；Do not lifted for treating impotence, seminal emission is early Let out, cold sperm infertility, dribbling urination, dyspnea and cough due to deficiency of the kidney, arthralgia pain due to rheumatism, wither soft or numb contraction of muscles and bones is anxious, hemiplegia, climacteric high blood Pressure.

Beneficial effects of the present invention.

The present invention is used for the Chinese medicine preparation for adjusting sleep function, according to the combination principle of traditional Chinese medicine, spina date seed, polygala, five Taste, wilsonii, arillus longan, Poria cocos, sealwort, radix polygonati officinalis, barrenwort, nine traditional Chinese medicines carry out prescription, effectively strengthen the original of each composition Drug effect, makes each composition complement each other, and produces good synergy, the organs such as conscience spleen kidney is not only acted on, while also acting on In cental system, hematological system, immune system etc., function of human body is comprehensively adjusted, the induction of insomnia is eliminated in terms of different Factor, improves the pathological state of body yin and yang imbalance.We are obtained by traditional Chinese medical science neurologist, nerve specialist for many years clinical experience, and formula is special Essence, evident in efficacy, fundamentally solution sleep is shallower, easily wake up with a start, and is had difficulty in going to sleep after waking up, or morning is waken up too early, and two or three are slept daily Individual hour even lies awake all night, even if or fall asleep, but dream is more and the malaise symptoms such as often have horrible nightmares.

Prescription raw material of the present invention is less, is complemented each other between flavour of a drug；Modern pharmacological research shows, spina date seed decocting liquid and its Soap is general, chromocor compound, spine date seed oil etc., is respectively provided with sedative-hypnotic effect；The total soap of spina date seed is general to give mouse stomach, can be substantially Mouse autonomic activities number of times is reduced, shortens mouse dropping asleep latency, also has confrontation to amphetamine induced mice activity increase Effect.In polygala containing the various active such as saponins compound, mouth xanthones compounds, oligosaccharides lipoid substance, alkaloid into Point；Modern pharmacological research proves, polygala and its polygalic acid have improve learning and memory, tranquilizing soporific, antidepression, it is anti-oxidant, Anti-aging, antibacterial anti-inflammatory, anti-mutagenesis, kobadrin, protection.Fruit of Chinese magnoliavine ethanol extract can significantly reduce mouse autonomic activities And the inhibitory action of maincenter tranquilizer chlorpromazine and reserpine to autonomic activities can be strengthened, resist central stimulant amphetamine pair The excitation of autonomic activities；Schizandrin can be such that rat striatum and hypothalamus DOPAMINE CONTENT IN RABBIT substantially increases, and point out five The central inhibitory action of taste alcohol first；Fructus Schisandrae Chinensis volatile oil can substantially shorten mouse sleep time caused by yellow Jackets, its Shorten the mechanism of the length of one's sleep caused by yellow Jackets, with syngignoscism.Manyprickle acanthopanax general flavones is to cardio-cerebrovascular There is a protective effect, manyprickle acanthopanax general flavones can raise synaptophysin p38 in rat cerebral tissue, growth associated protein GAP-43 expression, Build and strengthen again with promotion cynapse, improve the effect for building synaptic efficacy again, improve rat cell hypoxia damage model Cell survivaling number, with the neural cytosis of protection, by increasing capacitance it is possible to increase erythrocyte membrane fluidity, reduces blood viscosity, improves blood Hemorheological Indexes；Arillus longan methanolic extract subcutaneous administration mouse, it is found that its conflict is alleviated experiment drinking times and substantially increased；Card It is bright that there is obvious Antianxiety Activity.Arillus longan methanolic extract is used simultaneously with amobarbital, can be strengthened during low dosage and be slept Dormancy frequency and the length of one's sleep, there is coordinative role with malicious fly Tan alcohol, the sleep of sleep initial stage and enhancing amobarbital induction can be strengthened Time.Modern pharmacological research shows that sealwort can improve body's immunity, has reducing blood lipid, antiatherosclerosis, hypotensive to make With having expansion coronary artery and function of resisting myocardial ischemia, and have improving micro_circulation effect；There are the clear and definite anti-aging of comparison, hypoglycemic work With；Sealwort has the anti-stress effects such as antifatigue, resist oxygen lack.Radix polygonati officinalis has certain inhibitory action to heart, there is expansion blood vessel, rise The effect of blood pressure, reduction blood fat and Experiment on therapy atherosclerosis；There are hypoglycemic, reducing blood lipid, antibacterial；It can remove The free radical that organism metabolism is produced, with anti-aging effects；There is similar adrenal hormone, can also suppress the life of carcinoma It is long.Poria cocos decoction mouse peritoneal injection, can substantially reduce its spontaneous activity, and can resist caffeine induced mice and be overexcited； There is obvious synergy to the anesthetic effect of yellow Jackets；Poria cocos can strengthen pentothal to mouse central inhibitory action, Anesthesia duration significantly extends, with calm effect.Barrenwort can strengthen hypothalamus-hypophysis-gonad axis and adrenal cortex The secreting function of the internal systems such as axle, Thymus Axis, extraction ofHerba Epimedii can influence " impotence " model mice DNA to synthesize, and promote Enter the synthesis of protein, adjust cell metabolism, hence it is evident that increase the weight of animals and resistance to jelly time, barrenwort alcohol extract can significantly increase Plus extrasomatic rabbit heart coronary flow, barrenwort decoction and decocting alcohol leaching liquid have antihypertensive effect to rabbit, cat, rat intravenous.

We are obtained by Chinese medicine othopedics expert for many years clinical experience, and formula is specially smart, evident in efficacy；The compatibility of prescription of the present invention Lexical or textual analysis：Spina date seed is sweet, flat in side, the thoughts of returning home, Liver Channel；Nourishing heart tonifying liver, antitoxic heart-soothing and sedative is monarch drug in a prescription.The polygala thoughts of returning home, kidney channel, tranquilize the mind and promote the intelligence And solve strongly fragrant；The fruit of Chinese magnoliavine is sweet, temperature, return lung, the heart, kidney channel, nourshing kidney of astringing the lung, the arrest sweating that promotes the production of body fluid, antitoxic heart-soothing and sedative；Polygala, the fruit of Chinese magnoliavine help kidney to hide Held in essence, kidney essense in meeting at kidney under the heart, the motive, then mind is peaceful；Arillus longan is sweet, warm-natured, the thoughts of returning home, the spleen channel, tonifying heart and spleen, supports Blood and tranquilizing mind；Poria cocos is sweet, light, flat, the thoughts of returning home, lung, the spleen channel, eliminating dampness and diuresis, strengthening the spleen and stomach, antitoxic heart-soothing and sedative.Arillus longan tonifying spleen, Poria cocos is good for Spleen, strong then micro- biochemistry of foodstuff essence of spleen is active, it is precise and tiny on give in the heart, then the mind must be supported, and upper four taste is ministerial drug altogether.Though the cause of disease of being insomnia It is many, but men outnumbered women for total category, imbalance of yin and yang, side's sealwort flat property and sweet taste, invigorating the spleen, moistening lung, kidney-nourishing, flat tonifying spleen, lung, kidney Threefold Canon it The moon, radix polygonati officinalis cold nature is sweet, and nourishing yin to moisten dryness promotes the production of body fluid to quench thirst, and two medicines, which are shared, answers the heart-yin, and painstaking effort life, mind is supported, and the mind is pacified, Right kind tonifying yin person, must treating YIN within YANG, side uses barrenwort kidney-replenishing, makes YIN matched with sufficient YANG making living things fully vivid, make two yin tonics effects more Good, wilsonii return liver warp, kidney channel help the monarch and his subjects' filling liver kidney, and can invigorate blood circulation arteries and veins again, can anti-many helps too, hinder blood operation, on Four medicines are supplementary drug altogether.All formulas are matched antitoxic heart-soothing and sedative, Yangyin Rougan liver, invigorating spleen and kidney, the four dirty same good recipes controlled, be insomnia for conditioning.

Embodiment

The present invention is described in further details with reference to specific embodiment.

Embodiment 1.

A kind of Chinese medicine preparation for being used to adjust sleep function, is made up of the raw material of following parts by weight：Spina date seed 15 Part, 9 parts of polygala, 9 parts of the fruit of Chinese magnoliavine, 9 parts of arillus longan, 9 parts of Poria cocos, 6 parts of sealwort, 6 parts of radix polygonati officinalis, 6 parts of wilsonii, 6 parts of barrenwort.

The preparation method for being used to adjust the Chinese medicine preparation of sleep function, comprises the following steps.

Step 1, pretreatment：Material is got with production ordering and checks material code name, the name of an article, specification, numbering and weight etc., And carry out removing coat and sterilization.

Step 2, granulation：Each raw material is taken by formula rate；Ethanol is reclaimed after alcohol extracting, extraction, finite concentration time shift is concentrated into Let cool place and stand 3 hours, make precipitation completely, filtering, filtrate low temperature is concentrated into thick paste, and proportion is 1.30, that dries puts appropriate appearance In device, add thick medicinal extract and stir and evenly mix, if necessary plus appropriate 50% ethanol, adjustment humidity and viscosity are made that " hand is pinched into Group, light pressure then dissipates " softwood, then softwood is added in oscillating granulator hopper, makees reciprocal by means of blunt hexagon prismatic rotating shaft Rotate, softwood is pressed through screen cloth（10-14 mesh）Wet granular is made；Wet grain standard is placed in jolt in the palm, should have sense of heaviness, carefully Powder is few, and wet grain size is neatly advisable without strip；Icing Sugar, dextrin and thick medicinal extract（1.35-1.40,50-60 DEG C）Ratio is 3：1：1, It can suitably be adjusted according to the proportion of thick medicinal extract, property and medication purpose, dry particl water content≤6.0% should be controlled.

Step 3, drying：After granulation, processing is dried, drying temperature control is at 40 DEG C, and drying time is 8 hours.

Step 4, whole grain：There is part to lump and adhesion after particle drying；Dried material is carried out in pelletizing machine cold But palpus re-sieving after, big particle is removed with 14 mesh sieves, then removes fine powder with 60 mesh sieves, makes particle uniform（Fine powder can be made again Grain）.

Step 5, mixing filling：The material after step 4 whole grain is added after amylum pregelatinisatum, mix equal in mixer It is even, then packed on automatic packaging machine.

Step 6, thermal contraction：Ready-made inner wrapping product is accomplished fluently into the corresponding date of manufacture, heat shrink films is packaged and carries out hot receipts Contracting.

Step 7, metal detection：Product after thermal contraction is placed on food metal detector and detected, is then packed Packing, obtains finished product.

Step 8, storage：Finished product is put into the qualified area of product of storehouse.

Embodiment 2.

A kind of Chinese medicine preparation for being used to adjust sleep function, is made up of the raw material of following parts by weight：Spina date seed 10 Part, 5 parts of polygala, 5 parts of the fruit of Chinese magnoliavine, 5 parts of arillus longan, 5 parts of Poria cocos, 15 parts of sealwort, 15 parts of radix polygonati officinalis, 15 parts of wilsonii, barrenwort 15 Part.

Embodiment 3.

A kind of Chinese medicine preparation for being used to adjust sleep function, is made up of the raw material of following parts by weight：Spina date seed 5 Part, 15 parts of polygala, 15 parts of the fruit of Chinese magnoliavine, 15 parts of arillus longan, 15 parts of Poria cocos, 5 parts of sealwort, 5 parts of radix polygonati officinalis, 5 parts of wilsonii, barrenwort 5 Part.

First, research of the Chinese medicine preparation of present invention regulation sleep function to insomnia rat model sleep effect.

This experiment uses fenclonine（PCPA）The method of intraperitoneal injection replicates insomnic rats model, with embodiment 1 Regulation sleep function Chinese medicine preparation therapeutic intervention, using Jieyu ' anshen Granules as positive control drug, observation experiment animal General state（The state of mind, coat color, food ingestion, amount of drinking water, the reaction stimulated to external world, death condition）, body weights （Weighed in situation before packet administration, at the end of experiment）And yellow Jackets are righted when testing total to Sleep latency, sleep Between influence.

This experiment the data obtained mean ± standard deviation（x±s）Represent, statistics is carried out using the softwares of SPSS 10.0 Analysis-one-way analysis of variance, P<0.05 is with statistical significance.

1. test modeling.

Wistar male rats 120（Liaoning University of TCM's Experimental Animal Center is provided）, 8-9 week old, body weight 180-210g；20-22 DEG C of laboratory temperature, relative humidity 45%-65%, natural lighting；Reagent uses chlorophenylalanine （PCPA）, Jieyu ' anshen Granules, yellow Jackets, weighed in after 120 rat adaptability are fed 7 days, 7 days, at random It is divided into blank control group 20, modeling group 100, modeling group intraperitoneal injection PCPA suspensions, continuous injection 2 days, consumption For rat body weight 400mg/kg, blank group is injected intraperitoneally after isometric alkalescent physiological saline, first time abdominal cavity note 36h, empty Yellow Jackets 30mg/kg is injected intraperitoneally in white group and modeling group, lifts rat tail, rat abdomen is placed on into cushion block upward On.The Sleep latency and sleep time of rat are recorded, using righting reflex loss to sleep, is recovered with righting reflex For awakening, yellow Jackets are righted in experiment, compare the difference between blank group and modeling group Sleep latency, total sleep time It is different, P<0.05, it is statistically significant, point out modeling success；Two groups of rat yellow Jackets right the comparison of experiment, are shown in Table 1.

1 two groups of rat yellow Jackets of table right the comparison of experiment（X ± s, min）.

Note：With blank group ratio^*P<0.05。

2. experiment packet and administration.

The continuous 7 days physiological saline gavages of 20 rats of blank group, 100 rats of model group are randomly divided into 5 groups, every group 20 Only.Respectively model group:It is injected intraperitoneally after PCPA, gives physiological saline gavage within continuous 7 days；The low dose group of embodiment 1:Abdomen After chamber injection PCPA, 6g/kg low dosage gavages are given within continuous 7 days；The middle dose group of embodiment 1:It is injected intraperitoneally after PCPA, continuously Give 12g/kg middle dosage gavages within 7 days；The high dose group of embodiment 1：It is injected intraperitoneally after PCPA, gives the high agent of 24g/kg within continuous 7 days Measure gavage；Jieyu ' anshen Granules group（Positive drug control group）:It is injected intraperitoneally after PCPA, gives within continuous 7 days 3.65g/kg solutions Strongly fragrant electuary gavage of calming the nerves.

3. experimental result.

Ordinary circumstance：Blank group rat spirit is good, and reaction is quick, and hair luster, body weight substantially increases.Model group rats Spirit is excited, the hard coarse, tarnish of hair, irritability, and dietary amount is reduced, drinking-water increases, and is become thin.Each dosage group of embodiment 1 and sun Property the medicine group rat state of mind, activity and response situation be not so good as blank group rat, body weight increase is slow compared with blank group.

Body weights：At the end of experiment, model group rats body weight evolution is each significantly lower than blank group rat, embodiment 1 Dosage group and positive drug group rat（P<0.05）.Each dosage of embodiment 1, positive drug control group rat body weight are significantly lower than blank Control group（P<0.05）；Insomnia Chinese medicine preparation each group is compared with positive drug control group to be not statistically significant；Prompting：By controlling Treat, the Chinese medicine preparation and Jieyu ' anshen Granules of present invention regulation insomnia can increase rat body weight；Each group rat body weight incrementss, It is shown in Table 2.

The comparison of each group rat body weight incrementss of table 2（X ± s, g）.

Note：The * P compared with normal group<0.05；The #P compared with model group<0.05；Compared △ P with positive drug control group> 0.05。

Sleep latency, total length of one's sleep：Righted with yellow Jackets experiment measure insomnia model group, embodiment 1 it is low, Middle and high dosage group, positive drug control group Sleep in Rats incubation period are apparently higher than blank group（P<0.05）；Have a sleepless night Chinese medicine preparation it is low, Middle and high dosage group and positive drug control group Sleep in Rats incubation period is significantly lower than insomnia model group（P<0.05）；Insomnia Chinese medicine is matched somebody with somebody The basic, normal, high dosage group in side is compared with positive drug control group to be not statistically significant.Have a sleepless night model group, insomnia Chinese medicine preparation it is low, Middle and high dosage group, positive drug control group Sleep in Rats duration are significantly lower than blank group（P<0.05）；The present invention is basic, normal, high Dosage group and positive drug control group Sleep in Rats duration are apparently higher than insomnia model group（P<0.05）, it is shown in Table 3.

The each group rat yellow Jackets of table 3 right the comparison of experiment（X ± s, min）.

4. conclusion.

The present invention plays the role of the general state, the increase rat body weight that improve insomnia rat model, and can shorten insomnia The Sleep latency of rat model and extension sleep total time.

First, model case.

1. patient, man 37 years old, is insomnia 7,8 years, heavy then be insomnia whole night, vexed easily to exert, two just can, day row 1 time, pain in the back, Meet it is cold and cool aggravate, forgetful, with distending pain in the head, mood is gloomy, previously there is a gout, hypertension history, and it is greasy to look into the red tongue of patient's tongue, small and wiry pulse Number；Tcm diagnosis：It is insomnia（Irascibility disturbs cardioid）；Prescription：The traditional Chinese herbal decoction that the formula of embodiment 1 is made:Spina date seed 15g, polygala 9g, fruit of Chinese magnoliavine 9g, arillus longan 9g, Poria cocos 9g, sealwort 6g, radix polygonati officinalis 6g, wilsonii 6g, barrenwort 6g.

14 pairs, daily one pair, decocting is to 300ml, each 100ml, three times a day orally；Further consultation after two weeks, patient sleeps at night Uneasiness, vexed easily to exert improvement, night can be fallen asleep 5 hours or so, and number of times of waking up is reduced.Advise this side of patient's following the service, follow-up 1 year, pain in the back Take a turn for the better, existing patient sleeps at night.

2. patient Zhao, man 74 years old, is chief complaint with " more than 20 years of uneasy sleeping at night ", it is existing symptoms include：Uneasy sleeping at night, dreaming often and waking easily, Difficulty is slept after waking up, and occasionally has vexed, cold, bitter taste, and two is just normal, and diet is fine.Have a medical check-up：Pink tongue, indentation, white tongue；Tcm diagnosis： It is insomnia（Yang deficiency of spleen and stomache）；Prescription：The traditional Chinese herbal decoction that the formula of embodiment 2 is made：Spina date seed 10g, polygala 5g, fruit of Chinese magnoliavine 5g, Arillus longan 5g, Poria cocos 5g, sealwort 15g, radix polygonati officinalis 15g, wilsonii 15g, barrenwort 15g.

14 pairs, daily one pair, decocting is to 300ml, each 100ml, three times a day orally；Further consultation after one week, patient sleeps at night Uneasiness, dreaminess symptom takes a turn for the better, and still easily wakes up, but number of times reduction of waking up, and can be fallen asleep after waking up.Advise this side of patient's following the service, follow-up 1 year, Existing patient sleeps at night.

3. patient Wu, man 45 years old, is chief complaint with " night sleep nearly 10 years of dreaminess ", it is existing symptoms include：Difficulty falling asleep, dreaming often and waking easily, Night sleeps 3-4 hours, daytime sleepiness, fatigue and weak, activity postemphasis, when it is vexed, stool 3-5 days once, matter is hard；Past medical history：It is strong Health.Have a medical check-up：The red thin tongue of tongue, deep wiry pulse；Tcm diagnosis：It is insomnia（Type of deficiency of both the heart and spleen）；Prescription：During the formula of embodiment 3 is made Medicine decoction:It is spina date seed 5g, polygala 15g, fruit of Chinese magnoliavine 15g, arillus longan 15g, Poria cocos 15g, sealwort 5g, radix polygonati officinalis 5g, wilsonii 5g, excessive Sheep leaves of pulse plants 5g.

14 pairs, daily one pair, decocting is to 300ml, each 100ml, three times a day orally；Further consultation after one week, patient falls asleep Difficult symptom takes a turn for the better, still dreaming often and waking easily, and night sleeps 4-5 hours, advises this side of patient's following the service, follow-up 1 year, patient's still dreaminess, and night sleeps 6 Hour or so, this side of existing patient's following the service.

Claims (6)

1. a kind of Chinese medicine preparation for being used to adjust sleep function, it is characterised in that include the raw material of following parts by weight：Spina date seed 5-15 parts, 5-15 parts of polygala, 5-15 parts of the fruit of Chinese magnoliavine, 5-15 parts of wilsonii, 5-15 parts of arillus longan, 5-15 parts of Poria cocos, sealwort 5-15 Part, 5-15 parts of radix polygonati officinalis, 5-15 parts of longspur epimedium.

2. the Chinese medicine preparation as claimed in claim 1 for being used to adjust sleep function, it is characterised in that be by the original of following number Material composition：15 parts of spina date seed, 9 parts of polygala, 9 parts of the fruit of Chinese magnoliavine, 9 parts of arillus longan, 9 parts of Poria cocos, 6 parts of sealwort, 6 parts of radix polygonati officinalis, wilsonii 6 Part, 6 parts of longspur epimedium.

3. the Chinese medicine preparation as claimed in claim 1 for being used to adjust sleep function, it is characterised in that be by following parts by weight Raw material composition：10 parts of spina date seed, 5 parts of polygala, 5 parts of the fruit of Chinese magnoliavine, 5 parts of arillus longan, 5 parts of Poria cocos, 15 parts of sealwort, 15 parts of radix polygonati officinalis, 15 parts of wilsonii, 15 parts of longspur epimedium.

4. the Chinese medicine preparation as claimed in claim 1 for being used to adjust sleep function, it is characterised in that be by following parts by weight Raw material composition：5 parts of spina date seed, 15 parts of polygala, 15 parts of the fruit of Chinese magnoliavine, 15 parts of arillus longan, 15 parts of Poria cocos, 5 parts of sealwort, 5 parts of radix polygonati officinalis, 5 parts of wilsonii, 5 parts of longspur epimedium.

5. being used for as described in claim 1-4 is any adjusts the Chinese medicine preparation of sleep function, it is characterised in that the Chinese medicine is matched somebody with somebody Chinese herbal medicine powder, the water-bindered pill, honeyed bolus is made in side.

6. being used for as described in claim 1-4 adjusts the Chinese medicine preparation of sleep function, it is characterised in that comprise the following steps：

Step 1, pretreatment：Material is got with production ordering and material code name, the name of an article, specification, numbering and weight etc. is checked, and is gone forward side by side Row removes coat and sterilization；

Step 2, granulation：Each raw material is weighed by formula rate；Raw material is put into mixer-granulator and pelletized；

Step 3, drying：After granulation, processing is dried, drying temperature is controlled at 35-40 DEG C；

Step 4, whole grain：Dried material is subjected to whole grain processing in pelletizing machine；

Step 5, mixing filling：The material after step 4 whole grain is added after the auxiliary materials such as lactose, amylum pregelatinisatum or superfine silica gel powder, It is well mixed, is then packed on automatic packaging machine in mixer；

Step 6, thermal contraction：Ready-made inner wrapping product is accomplished fluently into the corresponding date of manufacture, heat shrink films is packaged and carries out thermal contraction；

Step 7, metal detection：Product after thermal contraction is placed on food metal detector and detected, then packaging packing, Obtain finished product.