CN107126290B - Artificial optic nerve casing for experimental animal - Google Patents
Artificial optic nerve casing for experimental animal Download PDFInfo
- Publication number
- CN107126290B CN107126290B CN201710280236.9A CN201710280236A CN107126290B CN 107126290 B CN107126290 B CN 107126290B CN 201710280236 A CN201710280236 A CN 201710280236A CN 107126290 B CN107126290 B CN 107126290B
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- China
- Prior art keywords
- hollow cylinder
- half hollow
- optic nerve
- lower half
- upper half
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 210000001328 optic nerve Anatomy 0.000 title claims abstract description 50
- 238000010171 animal model Methods 0.000 title claims abstract description 12
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims abstract description 4
- 239000004926 polymethyl methacrylate Substances 0.000 claims abstract description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims 1
- 230000006378 damage Effects 0.000 abstract description 7
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 206010040007 Sense of oppression Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 206010029174 Nerve compression Diseases 0.000 description 2
- 208000030768 Optic nerve injury Diseases 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 1
- 206010019196 Head injury Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000005065 mining Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000009978 visual deterioration Effects 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Instructional Devices (AREA)
- Prostheses (AREA)
Abstract
The invention provides an artificial optic nerve casing for experimental animals, which is made of nontoxic and environment-friendly polymethyl methacrylate and comprises an upper half hollow cylinder and a lower half hollow cylinder, wherein one sides of the upper half hollow cylinder and one side of the lower half hollow cylinder are connected together through a connecting part, a hemispherical bulge is arranged in the center of the lower half hollow cylinder, the upper half hollow cylinder is provided with an upper extension part, the upper extension part is provided with two square holes, the lower half hollow cylinder is provided with a lower extension part, the lower extension part is provided with two buttons, the buttons are sleeved on the optic nerve and are buckled on the lower half hollow cylinder, the hemispherical bulge can press the local part of the optic nerve for a long time, and the pressing degree can be controlled by selecting different hemispherical bulges to damage the optic nerve quantitatively.
Description
Technical Field
The invention belongs to a medical model tool, and particularly relates to an artificial optic nerve casing for animal experiments.
Background
Indirect Traumatic Optic Neuropathy (ITON) is a serious damage to optic nerve function caused by sudden external blunt force striking on the frontotemporal part above the orbital-eyebrow arch, and most patients show acute visual deterioration after injury, even complete loss. According to statistics, the ITON accounts for about 5% of closed craniocerebral injury, and along with rapid development of industrial and mining industry, traffic industry, tourism industry and the like, the incidence rate of ITON is increasing in China, and the ITON becomes common serious eye trauma.
The pathogenesis of ITON comprises three aspects, namely, instant external force indirectly acts on optic nerves to cause nerve injury, fractured optic nerve sleeve impacts and generates long-term compression on the optic nerves, and the intact part of the optic nerve sleeve forms constraint on the optic nerves of inflammatory edema to further cause high pressure in the tube. For better treatment of the disease, there is an urgent need for a quantitative/analyzable animal model that is consistent with the pathogenesis of the disease, and includes a number of aspects: firstly, manufacturing extrusion pressure to act on optic nerve; secondly, the pressure can be quantized/graded; and thirdly, the intraductal high pressure state of the local optic nerve can be simulated.
In order to cause pressure to optic nerves, the patent application No. CN200820155530.3 provides an automatic quantitative injury device for peripheral nerves of experimental animals, the motor control is adopted, the optic nerve sleeve is accurately pressurized, the method is accurate and quantitative, but only temporarily causes damage to the optic nerves, and the high-pressure state in a long-term optic nerve pipe after ITON cannot be simulated; the article on page 283-: the morphological research of optic nerve injury on retinal structure provides an optic nerve impact animal model, the optic nerve of the apical part of the orbit of a guinea pig is exposed in the cranium by operation, a blunt round head wood strip is vertically arranged above the optic nerve, a weight is completely vertically and freely dropped from a high position to impact the wood strip, so that the indirect impact injury of the optic nerve intraorbital section in the cranium is caused. Therefore, the current technology can not completely meet the three conditions, and a model which can simultaneously meet the requirements of manufacturing the extrusion pressure acting on the optic nerve, quantifying/grading the pressure and simulating the intraductal high-pressure state of the local optic nerve needs to be designed for research.
Disclosure of Invention
The invention provides an artificial optic nerve casing for experimental animals, which comprises an upper half hollow cylinder and a lower half hollow cylinder, wherein one sides of the upper half hollow cylinder and one side of the lower half hollow cylinder are connected together through a connecting part, a hemispherical bulge is arranged in the center of the lower half hollow cylinder, the upper half hollow cylinder is provided with an upper extension part, two square holes are arranged on the upper extension part, the lower half hollow cylinder is provided with a lower extension part, and two buttons are arranged on the lower extension part.
Specifically, the inner diameters of the upper half hollow cylinder and the lower half hollow cylinder are the same and are 0.1-3 mm.
Specifically, the diameters of the hemispherical bulges are set in a gradient manner to different sizes.
Specifically, the artificial optic nerve casing is made of polymethyl methacrylate.
The invention has the advantages that: the optic nerve compression sleeve is sleeved on an optic nerve, the hemispherical protrusions can compress the optic nerve locally for a long time, the compression degree can be controlled by selecting different hemispherical protrusions, the optic nerve can be quantitatively damaged, and the optic nerve compression sleeve can be detached after a period of time to simulate optic nerve decompression operation.
Drawings
FIG. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a front view of the present invention.
Fig. 3 is a closed state diagram of the present invention.
Fig. 4 is a closed state diagram of the present invention.
Fig. 5 is a schematic diagram of the present invention.
Detailed Description
The artificial optic nerve casing for the experimental animal provided by the embodiment is made of non-toxic environment-friendly polymethyl methacrylate, and has a structure shown in fig. 1-4, and comprises an upper half hollow cylinder 100 and a lower half hollow cylinder 200, wherein the inner diameters of the upper half hollow cylinder 100 and the lower half hollow cylinder 200 are the same, and because the thicknesses of optic nerves of different experimental animals are different, the inner diameters of different hollow cylinders are set to be different sizes between 0.1 mm and 3mm for matching experiments on different optic nerves; first hollow cylinder 100 links together through connecting portion 300 with one side of second hollow cylinder 200, the opposite side of first hollow cylinder 100 is equipped with extension portion 110, be equipped with two square holes 111 on the extension portion 110, the opposite side of second hollow cylinder 200 is equipped with extension portion 210 down, be equipped with two buckles 211 on the extension portion 110 down, pass square hole 111 with first hollow cylinder 100 and second hollow cylinder 200 with buckle 211 and link together and form hollow cylinder, second hollow cylinder 200 center has hemisphere arch 400, and the size of different diameters is different to the oppression dynamics of nerve, consequently is the gradient with hemisphere arch 400's diameter and sets up different sizes into.
When the artificial optic nerve sleeve is used, as shown in fig. 5, the artificial optic nerve sleeve with the matched inner diameter is selected to be sleeved on an optic nerve, the button 211 penetrates through the square hole 111 to be fastened, the hemispherical bulge 400 at the center of the semi-hollow cylinder 200 can locally extrude the optic nerve to generate constant pressure, and if the artificial optic nerve sleeve is not taken down, the pressure exists all the time, so that the effect of extruding the optic nerve by the bone flap of the optic nerve sleeve for a long time can be simulated.
The hemispherical bulge 400 of different artificial optic nerve sleeves is that the gradient sets up to different diameters size and forms multiple specifications, and the hemispherical bulge 400 of different specifications is different to the oppression power of optic nerve, can come control oppression degree through the size of selecting hemispherical bulge 400, can quantitatively damage optic nerve, pull down the effect that can simulate optic nerve decompression operation after a period of time with it.
The above embodiments are only for the purpose of illustrating the present invention in detail, and are not to be construed as limiting the invention, and other persons in the art may make any changes and substitutions to the technical solution of the present invention without inventive efforts, and all fall within the protection scope of the present invention.
Claims (3)
1. An artificial optic nerve cannula for experimental animals is characterized in that: the structure comprises an upper half hollow cylinder (100) and a lower half hollow cylinder (200), wherein one sides of the upper half hollow cylinder (100) and the lower half hollow cylinder (200) are connected together through a connecting part (300), a hemispherical bulge (400) is arranged in the center of the lower half hollow cylinder (200), an upper extending part (110) is arranged on the other side of the upper half hollow cylinder (100), two square holes (111) are formed in the upper extending part (110), a lower extending part (210) is arranged on the other side of the lower half hollow cylinder (200), and two buckles (211) are arranged on the lower extending part (210); the diameters of the hemispherical bulges (400) are set to different sizes in a gradient manner, and the buttons (211) penetrate through the square holes (111) to connect the upper half hollow cylinder (100) and the lower half hollow cylinder (200) together to form a hollow cylinder.
2. The artificial optic nerve cannula for experimental animals according to claim 1, wherein: the inner diameters of the upper half hollow cylinder (100) and the lower half hollow cylinder (200) are the same, and the size is 0.1-3 mm.
3. The artificial optic nerve cannula for experimental animals according to claim 1, wherein: the manufacturing material is polymethyl methacrylate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710280236.9A CN107126290B (en) | 2017-04-26 | 2017-04-26 | Artificial optic nerve casing for experimental animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710280236.9A CN107126290B (en) | 2017-04-26 | 2017-04-26 | Artificial optic nerve casing for experimental animal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107126290A CN107126290A (en) | 2017-09-05 |
| CN107126290B true CN107126290B (en) | 2021-07-09 |
Family
ID=59715208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710280236.9A Expired - Fee Related CN107126290B (en) | 2017-04-26 | 2017-04-26 | Artificial optic nerve casing for experimental animal |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107126290B (en) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030225347A1 (en) * | 2002-06-03 | 2003-12-04 | Argenta Louis C. | Directed tissue growth employing reduced pressure |
| CN201227291Y (en) * | 2008-07-22 | 2009-04-29 | 广州知光生物科技有限公司 | Nerve package clip |
| CN101433475B (en) * | 2008-12-03 | 2012-03-21 | 南通大学 | Artificial nerve implant with path for guiding growth |
| MX2011006991A (en) * | 2008-12-31 | 2011-08-04 | Kci Licensing Inc | Tissue roll scaffolds. |
| US8612002B2 (en) * | 2009-12-23 | 2013-12-17 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
| CN102302384A (en) * | 2011-07-12 | 2012-01-04 | 上海市中医医院 | Tube pressing-type chronic nerve root injury model in animal and constructing method and application thereof |
| ES2954248T3 (en) * | 2013-10-17 | 2023-11-21 | Fempulse Llc | Nerve stimulation devices |
| CN204744261U (en) * | 2015-05-20 | 2015-11-11 | 中南大学湘雅医院 | Nerve anti-blocking pressure protection tube |
| CN106333713A (en) * | 2015-07-08 | 2017-01-18 | 天津鸿海科技开发有限责任公司 | Protecting tube for vessels and nerves |
| KR101700886B1 (en) * | 2015-07-24 | 2017-02-01 | 한국과학기술연구원 | Neural probe array of high performance and for minimized damage of neuron |
| CN204971427U (en) * | 2015-09-25 | 2016-01-20 | 南阳医学高等专科学校第一附属医院 | Department of neurology hemostatic clamp |
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2017
- 2017-04-26 CN CN201710280236.9A patent/CN107126290B/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN107126290A (en) | 2017-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wu Ende Inventor after: Wu Wencan Inventor after: Tu Yunhai Inventor after: Nankaihui Inventor before: Wu Ende |
|
| CB03 | Change of inventor or designer information | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220719 Address after: 325000 Wenzhou Medical University, Chashan Higher Education Park, Ouhai District, Wenzhou City, Zhejiang Province Patentee after: WENZHOU MEDICAL University Address before: 325000 room 2-401, Hongyi garden, Xialv Puhong, Lucheng District, Wenzhou City, Zhejiang Province Patentee before: Wu Ende |
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| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210709 |
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| CF01 | Termination of patent right due to non-payment of annual fee |