CN106806758A - A kind of Chinese medicine preparation for treating acne - Google Patents

Abstract

The present invention provides a kind of traditional Chinese medicine for outer use for treating acne, and the parts by weight of various bulk drugs are in the preparation：10~15 parts of garden burnet, 10~15 parts of climbing groundsel, wood suffers from 10~15 parts of son, 10~15 parts of field pennycress, 10~15 parts of the root of large-flowered skullcap, 10~15 parts of the root of Dahurain angelica, 10~15 parts of rhizoma atractylodis, 10~15 parts of the red sage root, 10~20 parts of kuh-seng, 10~20 parts of the tuber of stemona, 10~20 parts of golden cypress, 10~20 parts of frutus cnidii, 10~20 parts of the root bark of white mulberry, 10~20 parts of honeysuckle, 10~20 parts of peppermint.The focus that can go directly of the invention, heat-clearing dissipates stasis of blood Herbal medicines for external use, focus is fully contacted, promoting blood circulation and removing blood stasis and promotion skin damaged quickly healing or the effect disappeared clearing heat and detoxicating to strengthen, improve capillary permeability, so as to reach the effect of heat-clearing and damp-drying drug, nourshing blood and promoting blood circulation, dispelling wind and arresting itching, make the pharmaceutical compositions of wind dispelling insecticide, promoting pus discharge and tissue regeneration, penetrated in vivo through skin, enhancing therapeutic action, improves curative effect.

Description

A kind of Chinese medicine preparation for treating acne

Technical field

The present invention relates to contain the medicinal preparation from plant, animal or mineral component, especially It is related to a kind of treat traditional Chinese medicine for external application of acne and preparation method thereof.

Background technology

Acne rosacea is more common in a middle-aged person of 30-50 Sui also known as brandy nose, and women is more than male, but seriously Case is generally found from male, is a kind of chronic inflammation disease for betiding Middle face.Acne rosacea is really Cut the cause of disease unclear, many factors are likely to induce or aggravate disease, including the easypro contracting nerve of local vascular Imbalance, demodex folliculorum and local repeated infection, using maror, drink, caloric stimulation, stress, Excited, endocrine dysfunction etc..In recent years, Helicobacter pylori infection and immune factor with This sick relation also begins to draw attention.

This course of disease is slow, is generally divided into for three phases, does not have obvious boundary between each phase.1. erythema hair The thin blood vessel dilatation phase：The erythema based on Middle face is shown as, can also add up cheek, forehead and lower chin. Erythema is manifested initially by, pungent on the feed can stimulate food, temperature cataclysm and spiritual nervous excitation time Substantially, it is long to become erythema perstans, and telangiectasis is engendered, in dendroid, main point Cloth is in nose and the wing of nose.It is often accompanied by that pore is thick and sebum secretion increases.Sustainable several months to the several years, afterwards Switch to the papulopustule phase.2. papulopustule phase：Erythema and it is telangiectatic on the basis of, repeatedly The pityriasis rubra papule of acne sample, warts, but formed without acne.Skin damaged can behave as sometimes it is deep inflammation Disease property tubercle or tumour.3. pachydermatosis phase：Due to long-term congested, repeated infection, the increasing of nose connective tissue Grow, sebaceous glands increases extremely, the protuberance tubercle that formation is differed in size, cause nose portion outward appearance loose, Deformity such as neoplasm.The sebaceous glands mouthful of the visible obvious expansion in pachydermatosis surface, there is strip thick white during extruding Seborrhea.Serious pachydermatosis is more common in the male of more than 40 years old.4. eye：After being more common in climacteric Women and the male of pachydermatosis phase.Blepharitis is shown as, conjunctivitis causes keratitis and iritis once in a while, Patient may occur in which eyes drying, foreign body sensation, shed tears, the symptom such as photophobia, eye-blurred.

Although this disease does not influence, and people's is healthy, have a strong impact on attractive in appearance, allow and suffer from this sick people and claimed It is " coppernose ", so as to influence the normal life of people.Clinically know Chinese and Western medicine or its conjunction using various Agent all fails to tackle the problem at its root, and particularly long-term use some drugses such as steroid is to skin Side effect can be produced to whole body, result is to cure the symptoms, not the disease, and is lost more than gain.Clinically also it is no lack of and still uses Some Chinese medicine treating skins disease, but effect is also preferable not to the utmost.

The content of the invention

The technical problems to be solved by the invention are, although this disease is without life danger, have a strong impact on It is attractive in appearance.After this disease occurs, patient face appearance is had a strong impact on, very big psychological burden and essence are brought to patient Refreshing pain.Western medicine is only treated with some hormone medicines, and also some patient is in medication repeatedly for a long time Certain drug resistance can be produced afterwards；Other prolonged application hormone medicine, destructible human immune system, Recurrence rate is caused to raise；It is touching refractory.Tcm clinical practice makees decoction oral with traditional Chinese physician with disease foreign side, with And some traditional Chinese medicine lotions, but therapeutic effect is not satisfactory, exist can induce drug resistance, high recurrence rate, The deficiencies such as medication inconvenience, preparation difficulty.So clinic is in the urgent need to there is provided a kind of instant effect, side effect Small, biocidal property is strong, the medicine of quality-high and inexpensive treatment acne, can effectively release the pain of patient.

In order to solve the above technical problems, the invention provides a kind of traditional Chinese medicine for outer use for treating acne, its The parts by weight of various bulk drugs are in the Chinese medicine preparation：10~15 parts of garden burnet, 10~15 parts of climbing groundsel, 10~15 parts of wood trouble, 10~15 parts of field pennycress, 10~15 parts of the root of large-flowered skullcap, 10~15 parts of the root of Dahurain angelica, rhizoma atractylodis 10~ 15 parts, 10~15 parts of the red sage root, 10~20 parts of kuh-seng, 10~20 parts of the tuber of stemona, 10~20 parts of golden cypress, cnidium monnieri 10~20 parts of son, 10~20 parts of the root bark of white mulberry, 10~20 parts of honeysuckle, 10~20 parts of peppermint.

Preferably, the parts by weight of various bulk drugs can also be in its described Chinese medicine preparation：Garden burnet 10~ 15 parts, 10~15 parts of climbing groundsel, 10~15 parts of wood trouble, 10~15 parts of field pennycress, 10~15 parts of the root of large-flowered skullcap, 10~15 parts of the root of Dahurain angelica, 10~15 parts of rhizoma atractylodis, 10~15 parts of the red sage root, 10~15 parts of kuh-seng, the tuber of stemona 10~15 Part, 10~15 parts of golden cypress, 10~15 parts of frutus cnidii, 10~15 parts of the root bark of white mulberry, 10~15 parts of honeysuckle, 10~15 parts of peppermint.

Preferably, the formulation of its Chinese medicine preparation can also be：Paste, spray, liniment, pulvis, Gel, facial mask or tincture.

In order to solve the above technical problems, the present invention also provides a kind of system of the traditional Chinese medicine for outer use for treating acne Preparation Method, the Chinese medicine preparation formulation includes for the preparation method of tincture：

The bulk drug is first cut into particle standby；The bulk drug that particle will be cut into again is put into 75% alcohol In, soak 7-10 days.

In order to solve the above technical problems, the present invention provides a kind of system of the traditional Chinese medicine for outer use for treating acne again Preparation Method, the external used medicine is gel, and its preparation method is comprised the following steps：

A. by the bulk drug, ethanol heat is extracted 2 times in addition to the root of Dahurain angelica and peppermint, merges concentrated extracting solution；

B. the filter residue extracting in water for ethanol being extracted 2 times, merges concentrated extracting solution；

C. the root of Dahurain angelica and peppermint are distilled into white crystals with the way of distillation；

D. above-mentioned steps are obtained in two kinds of extraction liquids of white crystals input mixing, mediation matrix is killed Bacterium tinning is into gel.

In the step a, can by the bulk drug except the root of Dahurain angelica and the additional ethanol of peppermint soak 1-2 hours, Heating is boiled 30~40 minutes, is filtered, and filtrate is standby；Filter residue adds ethanol to heat for second, boils 30~40 Minute, filtering, filtrate is standby；Merge extract solution twice, and concentrated extracting solution is standby.

In the step b, the dregs of a decoction that can be extracted ethanol add water extraction twice, and heating every time is boiled Boiling 40~50 minutes, filtering；Merge the extract solution of 2 times, be concentrated into the concentrate that relative density is 1.08； Filtering, stand 24 hours, after remove supernatant, obtain concentrated medicament.

In the step c, the root of Dahurain angelica and the peppermint way of distillation can be vaporized, the white crystals that collection is obtained, Powder is dried to, it is standby.

In the step d, the white crystalline powder that will can be collected into puts into two kinds that above-mentioned steps are obtained Extract in liquid, stir, heat, mediation matrix, into gel；The matrix is selected from：Poly- mountain Pear ester -80, triethanolamine, propane diols, semi-synthetic fatty glyceride, poloxamer, polyethylene glycol, One or more in lanolin.

The focus that can go directly of the invention, heat-clearing dissipates stasis of blood Herbal medicines for external use, is fully contacted focus, and the efficacy of a drug can be made to go directly Sick institute, promoting blood circulation and removing blood stasis and promotion skin damaged quickly healing or the effect disappeared clearing heat and detoxicating to strengthen, changes Kind capillary permeability, so as to reach the effect of heat-clearing and damp-drying drug, nourshing blood and promoting blood circulation, dispelling wind and arresting itching, makes to dispel Wind desinsection, the pharmaceutical compositions of promoting pus discharge and tissue regeneration, penetrate in vivo through skin, strengthen therapeutic action, improve treatment Effect.The present invention can be such that liquid directly infiltrates at skin damaged, make skin damaged healing acceleration, reach good controlling Therapeutic effect；And medicine is cheap and easy to get, clinic is promoted.

Specific embodiment

Acne be it is a kind of betide mid-face especially nose position with flush, capillary expand Open and papule, warts are the skin disease of major clinical feature.Its course of disease is very long, when it is light when weight, touching difficulty More, erythema type, papulopustular type and the type of pachydermatosis type three can be often divided into according to its symptom, a middle-aged person is mainly in, It is common with women.After this disease occurs, patient face appearance is had a strong impact on, bring very big psychology negative to patient Load and mental suffering.In long-term clinical practice, with scattered from clear a surname's removing pattogenic heat from the blood and toxic material from the body soup combination heat-clearing is intended Stasis of blood facial mask treats acne, achieves satisfactory effect.

The pathogenic factor of acne is still not clear so far, but known inducement is a lot, such as digestive system function it is disorderly, Endocrine function imbalance, mental element, be addicted to drink, maror stimulates etc., parasitic vermiform mite (i.e. hair Cysticercus) stimulation be also likely to be a major reason.Traditional Chinese medicine thinks：Acne polyphyly lung stomach accumulated heat, it is multiple Feel the heresy of wind-heat, caused by blood stasis condenses, but had a profound understanding of in long-term diagnosis and treatment this sick clinical practices " wet Accumulate in heat, evil strongly fragrant three is burnt, must not let out more, outgoing skin " it is even more its principle pathological mechanism.Because of three burnt tools Have and preside over all gas, the effect of Directorate-General DG's human body gasification, and《Interior warp》Say：" three burnt bladder persons, space between skin and muscles is in the least Mao Qiying.If " damp and hot fiery poison it is all it is evil in accumulate, Jiao's mechanisms of qi of retardance three, then three Jiao are not smooth, disturbance in functioning of QI, And then it is evil strongly fragrant three burnt, must not let out and more (form the vicious circle on pathology), can outgoing this is caused for rash Disease.Therefore, treat this disease can not only clear facilitaing lung stomach accumulated heat, more preferably with the burnt damp and hot methods of a surname smooth three. All medicines share, plays clear drop lung stomach volt fire altogether, leads the effect of three Jiao are damp and hot, and cooling and activating blood detoxifies off.In this way, Lung stomach volt fire both disappeared, three burnt damp and hot fire-evil must be removed, and mechanism of qi is freely sharp, on naivete steam, facial train of thought qi and blood and Adjust, its disease is when more.It is equipped with heat-clearing and dissipates stasis of blood Herbal medicines for external use, be fully contacted focus, the through disease institute of the efficacy of a drug can be made, It is clearing heat and detoxicating to strengthen, quickly healing or the effect disappeared of promoting blood circulation and removing blood stasis and promotion skin damaged.

Modern medicine thinks, acne is more because on the basis of seborrhea, secondary chlosma, Propionibacterium, Hair follicle insect infection and inspire.Modern pharmacological research is confirmed：The root of large-flowered skullcap has functions that broad-spectrum antiseptic, anti-inflammatory, right Propionibacterium has inhibitory action；With anti-inflammatory, antipyretic and laxative effective；Golden cypress is to most of Grain-positives Bacterium and part gram-negative bacteria have inhibitory action；Chlorogenic acid, isochlorogenic acid contained by honeysuckle, flavones Class material has different degrees of inhibitory action to various bacteriums；The tuber of stemona has good to staphylococcus aureus Good antibacterial activity；The red sage root is to various pathogens, especially staphylococcus, Propionibacterium, mycobacteria And some fungies have powerful inhibitory action, still there is preferably suppression to the staphylococcus aureus of resistance Make and use.Above antibacterial and anti-inflammation functions can the therapeutically effective mechanism of partial interpretation sheet.

Brandy nose is a middle-aged person's nasal surface portion chronic inflammation, and modern medicine study proves to be generally hair follicle insect infection institute Cause, be mainly shown as that erythema, telangiectasis, papule, warts, nasal tissue are plump, increase in tubercle It is raw.Treatment expelled the heat-evil with clearing lung-heat, adjust stomach, promoting blood circulation and removing blood stasis, desinsection it is antipruritic based on, just in tuber of stemona moistening lung Cough, desinsection it is antipruritic；The tuber of stemona has softening skin and kills the effect of parasite；Golden cypress stasis removing, purging intense heat Defaecation, the row stasis of blood are stimulated the menstrual flow；Root of large-flowered skullcap purging intense heat and detonicating, cooling blood and hemostasis；Frutus cnidii external application has desinsection removing dampness to relieve itching to act on； Garden burnet cooling blood and hemostasis, purging intense heat poison, and have astriction.All medicines are used, and are reached and are taken stopgap measures and effect a permanent cure.

Golden cypress heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, under band, heat Drench, tinea pedis, impotence is warded off, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema itch.Stir-baked CORTEX PHELLODENDRI with salt solution is grown Cloudy fall fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.《Chinese Pharmacopoeia》The power of golden cypress heat-clearing and damp-drying drug is carried, with The root of large-flowered skullcap, the coptis are similar, but are preferred with except lower the damp and hot of Jiao.

Kuh-seng is bitter, trembles with fear.The thoughts of returning home, liver, stomach, large intestine, bladder warp heat-clearing and damp-drying drug, desinsection, diuresis. For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, Mange leprosy；Eczema of scrotum is controlled outward, is often used in combination with golden cypress, be that the external use gynaecological for the treatment of vaginitis is good Medicine.

Frutus cnidii is pungent, hardship, temperature；It is slightly poisonous.Return kidney channel.Cure mainly warming kidney and enhancing body, eliminating dampness, wind-dispelling, Desinsection.For impotence, Gong Leng, cold-dampness under band, arthritis with fixed pain caused by dampness pain in the back；Control eczema of vulva, married woman's pruritus vulvae outward； Eczema of scrotum, is gynecological external use good medicine.《Bencao Jingshu》Carry：Frutus cnidii, bitter is put down；《Do not record》 It is pungent sweet nontoxic；Modern its smell in detail, when must and temperate-dryness, sun.Therefore swollen and ache in housewife people's the moon, Nan Ziyin Impotence is wet to itch, eliminating impediment gas, sharp joint, dislikes sore.《Do not record》Warming the middle warmer and descending qi, makes married woman's son clothes heat, man It is cloudy strong, make us having son.Lid can be dehumidified with tongue, temperature energy cold dispelling, pungent to moisten kidney, the sweet beneficial spleen of energy, therefore can be removed The wet disease of viscera connecting with this channel of all cold of insufficiency type of married woman man.Cold-dampness was both removed, then disease is gone, performance Yiyang, thus can disease, and There is help again.

Field pennycress is bitter in taste flat, has functions that clearing heat and detoxicating, apocenosis broken stasis of blood.Can cure acute appendicitis, diarrhea, Leukorrhea with reddish discharge, postpartum stasis of blood, red eye, swell pain.Enter stomach, large intestine, Liver Channel.Cure mainly it is clearing heat and detoxicating, The carbuncle that disappears apocenosis, blood circulation promoting competent silt.For acute appendicitis, lung carbuncle and sore and toxic, the chest and abdomen pain caused by the real heat stasis of blood is stagnant Bitterly, the disease such as postpartum stasis of blood.

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, invigorate blood circulation, relieving restlessness that clears away heart-fire.For the moon Through uncomfortable, closed dysmenorrhea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, it is vexed not Sleep.For sternal rib hypochondriac pain, arthralgia pain due to rheumatism, abdominal mass caking, sore swell and ache curative falls grieved, irregular menstruation of falling forward, Closed dysmenorrhea, postpartum stasis caused pain etc..Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea Pain has good effect..《Detailed outline》Carry：The red sage root, presses《The sensible opinion of married woman》Cloud, Siwu Tang controls gynecopathy, Pay no attention to antenatal postpartum, through water how much, it is all generally applicable, the only taste red sage root dissipate, cure mainly same.Gai Dan Joining can break place blood, the new blood of benefit, peaceful tire, and fall stillborn foetus, under only metrorrhagia is stagnant, menstruation regulating arteries and veins.The red sage root it is main into Point tanshinone has expansion of blood vessels, improves circulation, releases the effect such as intravascular coagulation, with promoting blood circulationization trace it Effect, and liver blood can be promoted to circulate, beneficial to liver cell regeneration.

Rhizoma atractylodis are drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.For abdominal fullness and distention, diarrhea oedema, tinea pedis Wei lame, Arthralgia pain due to rheumatism, anemofrigid cold, yctalopia.Rhizoma atractylodis have drying damp and strengthening spleen, effect of wind-damp dispelling.Cure mainly dampness Middle Jiao, wind-cold-dampness arthralgia, pin swelling and pain in knee, impotence is soft powerless, night blindness yctalopia.《Pearl sac》Day：" can be good for Stomach pacifies spleen, and all wet non-these that swells can not be removed.”《Compendium of Materia Medica》Say：" control damp phlegm and stay drink ... and under spleen is wet Stream, turbid drip under band, cunning rushes down intestines wind.”《Tang materia medica》Claim its energy " diuresis ".

Garden burnet cures mainly haematemesis, and spitting of blood, bleeding from five sense organs or subcutaneous tissue, hematuria is had blood in stool, hemorrhoid blood, bloody flux, uterine bleeding, red leukorrhea Under, sore, carbuncle and painful swelling, eczema, pruritus vulvae, scald, snake bite and insect sting.《Detailed outline》：Garden burnet, removes down Burnt heat, controls stool and urine blood trouble.Hemostasis, take cut off piece fry use, its tip then can promoting circulation of blood, can not know. Yang Shiying cloud：All sore pain persons add garden burnet, the person of itching plus the root of large-flowered skullcap.

Climbing groundsel, also known as nine inner bright, Herba Senecionis Scandentis.Latin name Herba Senecionis Scandentis. A kind of Chinese herbal medicine, be born under hillside, sparse woods, Lin Bian, roadside, in limes marginis thick grass.Its is cold in nature, taste Hardship, with clearing heat and detoxicating, improving eyesight, the effects such as antipruritic.It is used for anemopyretic cold, red eye, swell pain, diarrhea Dysentery, skin eczema boil.《Bencao Shiyi》：Main epidemic disease gas, knot is yellow, malaria miasma, cup poison, boils and takes it Tell down, also smash the places of biting such as deposited sore, worm snake dog.

Wood suffers from son：Scientific name Sapindus, Compendium of Materia Medica is referred to as wood and suffers from son, and Sichuan claims oil to suffer from son, Hainan Island Claiming bitter trouble tree, Taiwan also known as yellow mesh, soapberry has antibacterial, anti-dandruff, anticreep, whitening despeckle, grows Moisten the effect of skin：" soapberry can pre- anti-dandruff ", this be used for usual traditional, natural shield of washing It is exactly at all common sense for the Chinese of product.Washed hair using soapberry soap breast, hair loss is prevented to what It is also effective according to popular legend.Tea Polyphenols in soapberry is water-soluble substances, and being washed one's face with it can remove face Grease, convergence pore, can sterilize, sterilize, resisting age of skin, sight middle-ultraviolet lamp can be reduced and radiated Damage to skin etc..Forulic acid in soapberry is the generally acknowledged cosmetic factor of scientific circles, can improve skin Quality, makes its exquisiteness, gloss, high resilience.Simultaneously also antibacterial, anti-inflammatory, it is anti-oxidant, remove from Acted on by base, anticoagulation etc..Tartaric acid in soapberry can help skin removed to be deposited in the aging angle of outer layer Matter, accelerates skin renewal, helps improve skin whelk, blackspot, wrinkle, dry skin, coarse etc. Skin problem.

Tuber of stemona nature and flavor are sweet, hardship, tepor.Return lung is passed through.Cure mainly moistening lung to lower qi cough-relieving, desinsection.For new long Cough, pulmonary tuberculosis cough, pertussis；It is used for head louse outward, body louse, enterobiasis, private parts is disturbed and itched.The sweet tuber of stemona Moisten the lung and relieve the cough.Coughed for deficiency of Yin labor.The infusion and ethanol extract of Radix stemonae japonicae and other kind tubers of stemona, There is killing action to mosquitos and flies larva, head louse, clothing lice and bedbug etc., alcohol preserved material is compared with the effect of flooding agent 50% distillation aqueous suspension contact crab louse several minutes of big tuber of stemona ethanol soluble extractions can be killed, water Immersion liquid then 70% alcohol leaching liquids of invalid behead lice and crab louse effect it is higher than DDT and the strong of Dalmatian chrysanthemum The concentration tuber of stemona plays the role of to kill mouse pinworm in vitro.《Bencao Shiyi》：Fire is processed infusing drugs in wine and is drunk on an empty stomach, is gone Silkworm stings worm, and mange sore.

Root of Dahurain angelica meridian distribution of property and flavor：It is pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and clearing away cold, sensible analgesic, detumescence row Purulence, eliminating dampness stops band, relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, clearing the nasal passage, eliminating dampness stops band, detumescence and apocenosis.Control head Bitterly, pain in the supra-orbital bone, dentalgia, nasosinusitis, cold-dampness stomachache, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, Skin is dry itches, mange.《Haigoushen》：Control trusted subordinate's blood shouting pain, exorcising, main woman's metrorrhagia and vomit it is inverse, Improving eyesight, only lacrimation, treat married woman's drip blood, waist stomachache；Purulence can be lost.《Japan hanako materia medica》：Control hot eyes Nu Meat, and tire patching leakage slides, and breaks place blood, mends new blood, acute mastitis, carbuncle on the back, scrofula, intestines wind, hemorrhoid complicated by anal fistula, row Purulence, desolation, mange relieve pain myogenic, go face Shao- defect scars.

The root bark of white mulberry is the root skin of moraceae plants mulberry Morus alba L..Main product in Anhui, Henan, Zhejiang, The ground such as Jiangsu, Hunan.Effect：Removing heat from lung and relieving asthma, inducing diuresis for removing edema.For lung heat cough and asthma, the edema of the face, The diseases such as difficult urination.《Haigoushen》：Make, put down.Lung qi can be controlled and breathe heavily full, aqueous vapor edema, main wound is exhausted, Dredging water passages, disappear aqueous vapor, consumptive disease visitor's heat headache, interior tonifying for the deficiency.《Japan hanako materia medica》：Temperature, in tune, Lower gas.Dissolving phlegm is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, is killed abdomen and is hidden worm, and only cholera is vomited and diarrhoea.

Peppermint is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, head Pain, hot eyes, body heat, throat, gum such as swell and ache the disease.External application can control neuralgia, pruitus, fash With eczema etc..Dispelling wind, radiate, ward off dirty, removing toxic substances, affection of exogenous wind-heat, headache, abscess of throat, food stagnation gas Swollen, aphtha, toothache, sore scabies, urticaria, warm disease from the beginning of, rubella itch, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest. Bactericidal action：Menthol has very strong bactericidal action, and d- menthols are stronger than the bacteriostasis of 1- menthol. Promote Transdermal absorption effect：Foreign study shows that menthol can remarkably promote the effect of acetaminophen Transdermal absorption, Absorption is remarkably promoted to Acetospan, can make the bioavilability of radix bupleuri increases, and can remarkably promote The Transdermal absorption of paracetamol.This promotion Transdermal absorption effect is probably because menthol is by changing angle The transdermal penetration ability of the structural change medicine of matter layer lipid.

The root of large-flowered skullcap has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions.Cure mainly warm heat disease, the infection of the upper respiratory tract, Cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swells The diseases such as furuncle sore.The clinical practice antibacterial of the root of large-flowered skullcap is not worse than the coptis, and does not develop immunity to drugs.We by The characteristics of broad-spectrum antibacterial action is strong, it is special severe used in the infection of fungal culture miscellaneous bacteria, with root of large-flowered skullcap extract solution effect Very well.《Bencao Jingshu》：The root of large-flowered skullcap, its property is respectful clearly, so evil removing：Bitter is so eliminating dampness；Cold sensation of the genitalia institute To win heat, therefore lead all heat.All hot persons, with all over heat, jaundice, intestines are out-of-the-way, let out dysentery, all damp and hot victory for heat symptoms caused by an exopathgen Disease, analyse it, then all diseases are from recover.Bitter cold can be except damp and hot, so small intestine profit and water are from by source It is clear then flow clean.The blood person of closing, in blood system, i.e. thermal man's blood room, it is obstructed to make us Amenorrhea, damp and hot solution for real heat, Then Ying Qi is clearly and voluntarily.Sore subcutaneous ulcer erosion person is disliked, blood-head then stays knot, and is that carbuncle swells stain is rotten：Fiery ulcer person, Internal heat blood trouble, cool blood is except heat, then self-healing.The root of large-flowered skullcap has antiallergic action and antiinflammatory action：Root of large-flowered skullcap institute Can substantially suppress sensitized guinea pig rat small intestine in vitro with isolated tracheal to produced by antigen containing baicalin and baicalein Anaphylaxis contractile response, to the passive general allergy and cavy passivity skin of cavy and mouse Skin allergy, baicalin also has inhibitory action with baicalein.The root of large-flowered skullcap has refrigeration function, majority experiment card Bright, the effective ingredient baicalein of the root of large-flowered skullcap has refrigeration function.The root of large-flowered skullcap has detoxication, and baicalin has substantially Detoxication, this is probably because in the presence of glucuronidase, baicalin decomposites Portugal Grape uronic acid, and combined with various poisonous substances caused.The LD 50 that 10 milligrams of baicalin can improve strychnine reaches 2.5 times, and increase the hepatic glycogen content of carbon tetrachloride poisoning mouse.

Honeysuckle " one is come from《Compendium of Materia Medica》, be white due to being opened at the beginning of FLOSLONICERAE, after switch to yellow, Hence obtain one's name honeysuckle.Medicinal material honeysuckle is Caprifoliaceae woodbine honeysuckle and congener dry flower Or the flower that band is just opened.Honeysuckle is described as clearing heat and detoxicating good medicine from ancient times.The sweet cold air fragrance of its property, Gan Han Without injuring one's stomach, fragrance reaches thoroughly again can eliminating evil for heat-clearing.Honeysuckle can dispelling wind-heat, be also apt to removing summer-heat blood poison, For various febrile diseases, such as body heat, dermexanthesis, hair spot, heat toxin sore carbuncle, abscess of throat card, equal effect Significantly.Resisting pathogenic microbes acts on.To various pathogens for example staphylococcus aureus, hemolytic streptococcus, Escherichia coli, shigella dysenteriae comma bacillus, typhoid bacillus, paratyphosum Bacterium etc. have certain inhibitory action.

Preparation method of the invention：

The preparation method of face film agent of the present invention is：Garden burnet 1000g, climbing groundsel 1000g are taken, wood suffers from sub- 1000g, Field pennycress 1000g, root of large-flowered skullcap 1000g, root of Dahurain angelica 1000g, rhizoma atractylodis 1000g, red sage root 1000g, kuh-seng 1000g, Tuber of stemona 1000g, golden cypress 1000g, frutus cnidii 1000g, root bark of white mulberry 1000g, honeysuckle 1000g, peppermint 1000g；Bulk drug is first ground into meal, is further crushed, cross 100 mesh~120 mesh sieves, enabled 30% is being reached by the fine powder amount sieved, is being collected and fine powder a is obtained by the fine powder for sieving；120 are will not pass through again The meal input multi-function extractor of mesh sieve is extracted twice, adds the decocting of 10 times of amounts to boil for the first time 1 hour, the Secondary plus 8 times of amounts decocting is boiled 1 hour, merges decocting liquid twice, is filtered to get filtrate；Heating is concentrated into pasty state, Cooled down after being put into 80 DEG C of drying of baking oven, grind to form fine powder b, calling in glycerine after a is mixed with b is made facial mask Agent.

Use step：Cleaning face：With warm water clean skin of face after, then with 0.9% physiological saline Cotton balls cleaning skin；2. applying film：Take the scattered stasis of blood facemask powder boiling water of appropriate heat-clearing and reconcile into pasty state, treat slightly cool Even application is thick in facial 1-2mm afterwards, and external application plastic fresh-keeping membrane removes face with moisturizing after about 30min Film, cleans face.The next day applying film 1 time.

Externally used paste preparation method of the present invention：

According to the ratio of weight and number by first by the bulk drug garden burnet 1500g, climbing groundsel 1500g, wood is suffered from Sub- 1500g, field pennycress 1500g, root of large-flowered skullcap 1500g, rhizoma atractylodis 1500g, red sage root 1500g, kuh-seng 1500g, Tuber of stemona 1500g, golden cypress 1500g, frutus cnidii 1500g, root bark of white mulberry 1500g, honeysuckle 1500g are cut into Grain is standby；The bulk drug that particle will be cut into again is put into sesame oil, is soaked one day；Then the sesame oil of immersion Heated with slow fire with particulate matter, when bulk drug becomes withered and yellow, beeswax is called in filtering of removing slag, and small fire is slow It is slow to receive cream, add root of Dahurain angelica 1500g and peppermint 1500g that way of distillation distillation is vaporized into white crystals, patent medicine It is put into after cream 12-24 hours in cold water, is released fire-toxin.

Beeswax is the wax of honeybee secretion, with inducing astrigency, sore, myogenic, the function of analgesic, outward for bursting Ulcer is not held back, ulcer on the shank erosion, wound, burn and scald etc., suppress local organization inflammation, the life of promotion organization cell It is long, accelerate the healing of ulcerous skin.Pharmacological testing proves beeswax extract solution to bacillus larvae, honeycomb Bacillus has parallel antibacterial action.Beeswax is commonly used for the excipients of Chinese patent drug and the matrix of external-use ointment. Beeswax is used as medicine as the matrix of ointment can adjust soft durometer, improve the release of medicine and absorb.In this hair In bright Chinese medicine ointment, beeswax also functions as matrix while convergence, myogenic pain relieving drug effect is played Effect.

The preparation method of inventive gel agent：The medicine garden burnet 1500g, climbing groundsel 1500g, wood are suffered from Sub- 1500g, field pennycress 1500g, root of large-flowered skullcap 1500g, rhizoma atractylodis 1500g, red sage root 1500g, kuh-seng 1500g, Tuber of stemona 1500g, golden cypress 1500g, frutus cnidii 1500g, root bark of white mulberry 1500g, honeysuckle 1500g chopping add Enter ethanol to soak 1-2 hours, extract twice, heating every time is boiled 30~40 minutes, is filtered, and filtrate is standby； Filter residue extracting in water boils 30~40 minutes twice, every time, and filtering, filtrate is standby；Merging is extracted twice In liquid, and the standby multi-function extractor of concentrated extracting solution, filtrate decompression concentration staticly settles 24~48 Hour；Aspirate supernatant, is stirred after being heated to 40~50 DEG C, and ratio of weight and number is condensed at ambient pressure It is 500 parts of concentrate solution, adds the white crystals powder of the root of Dahurain angelica 1500g and peppermint 1500g of distillation vaporization End, adds matrix, stands, solidifies agglutination.The matrix is selected from：Tween-80, triethanolamine, Propane diols, one or more in semi-synthetic fatty glyceride, poloxamer, polyethylene glycol, lanolin.

General used matrix can be：Semi-synthetic fatty glyceride, lanolin, polyethylene glycol, medicine fine powder It is 1: 2~1: 4, preferably 1: 3 with the proportioning of matrix, or using poloxamer poloxamer as base Matter, its hydrophilic matrix for being widely used as suppository, with advantages below：Than the dissolving of other matrix Degree is soft, quick, and drugloading rate is also higher.

The preparation process of tincture of the present invention：The bulk drug is taken into garden burnet 1000g, climbing groundsel 1000g, wood Suffer from sub- 1000g, field pennycress 1000g, root of large-flowered skullcap 1000g, root of Dahurain angelica 1000g, rhizoma atractylodis 1000g, red sage root 1000g, Kuh-seng 1000g, tuber of stemona 1000g, golden cypress 1000g, frutus cnidii 1000g, root bark of white mulberry 1000g, honeysuckle 1000g, peppermint 1000g, immersion can be used for one week in being put into 75% alcohol.

The above, is only presently preferred embodiments of the present invention, is not to make other shapes to the present invention The limitation of formula, any those skilled in the art are subject to possibly also with the technology contents of the disclosure above Change or be modified as the Equivalent embodiments of equivalent variations.But it is every without departing from technical solution of the present invention Hold, any simple modification, the equivalent variations made to above example according to technical spirit of the invention With remodeling, the protection domain of technical solution of the present invention is still fallen within.

Claims (9)

1. a kind of Chinese medicine preparation for treating acne, it is characterised in that various raw materials in the Chinese medicine preparation The parts by weight of medicine are：10~15 parts of garden burnet, 10~15 parts of climbing groundsel, wood suffers from 10~15 parts of son, Patrinia scaniosaefolia 10~15 parts of grass, 10~15 parts of the root of large-flowered skullcap, 10~15 parts of the root of Dahurain angelica, 10~15 parts of rhizoma atractylodis, 10~15 parts of the red sage root, 10~20 parts of kuh-seng, 10~20 parts of the tuber of stemona, 10~20 parts of golden cypress, 10~20 parts of frutus cnidii, the root bark of white mulberry 10~ 20 parts, 10~20 parts of honeysuckle, 10~20 parts of peppermint.

2. the Chinese medicine preparation of acne is treated according to claim 1, it is characterised in that the Chinese medicine system The parts by weight of various bulk drugs are in agent：10~15 parts of garden burnet, 10~15 parts of climbing groundsel, wood trouble 10~ 15 parts, 10~15 parts of field pennycress, 10~15 parts of the root of large-flowered skullcap, 10~15 parts of the root of Dahurain angelica, 10~15 parts of rhizoma atractylodis are red 10~15 parts of ginseng, 10~15 parts of kuh-seng, 10~15 parts of the tuber of stemona, 10~15 parts of golden cypress, frutus cnidii 10~15 Part, 10~15 parts of the root bark of white mulberry, 10~15 parts of honeysuckle, 10~15 parts of peppermint.

3. the Chinese medicine preparation of acne is treated according to claim 2, it is characterised in that the Chinese medicine system The formulation of agent is：Paste, spray, liniment, pulvis, gel, facial mask or tincture.

4. it is a kind of as any one of claims 1 to 3 treat acne Chinese medicine preparation preparation method, Characterized in that, the Chinese medicine preparation formulation includes for the preparation method of tincture：

The bulk drug is first cut into particle standby；The bulk drug that particle will be cut into again is put into 75% alcohol In, soak 7-10 days.

5. a kind of preparation of the traditional Chinese medicine for outer use that acne is treated as any one of claims 1 to 3 Method, it is characterised in that the external used medicine is gel, its preparation method is comprised the following steps：

A. the bulk drug is merged into concentrated extracting solution except the root of Dahurain angelica and peppermint external application ethanol heat are extracted 2 times；

B. the filter residue extracting in water for ethanol being extracted 2 times, merges concentrated extracting solution；

C. the root of Dahurain angelica and peppermint are distilled into white crystals with the way of distillation；

D. above-mentioned steps are obtained in two kinds of extraction liquids of white crystals input mixing, mediation matrix is killed Bacterium tinning is into gel.

6. the preparation method of the Chinese medicine preparation of acne is treated according to claim 5, it is characterised in that In the step a, the bulk drug soaks 1-2 hour except the root of Dahurain angelica and the additional ethanol of peppermint, heat and boil 30~ 40 minutes, filtering, filtrate was standby；Filter residue adds ethanol to heat for second, boils 30~40 minutes, filters, Filtrate is standby；Merge extract solution twice, and concentrated extracting solution is standby.

7. the preparation method of the Chinese medicine preparation of acne is treated according to claim 6, it is characterised in that In the step b, the dregs of a decoction that ethanol was extracted are added water into extraction twice, heating every time boils 40~50 Minute, filtering；Merge the extract solution of 2 times, be concentrated into the concentrate that relative density is 1.08；Filtering, it is quiet Put 24 hours, after remove supernatant, obtain concentrated medicament.

8. the preparation method of the Chinese medicine preparation of acne is treated according to claim 7, it is characterised in that In the step c, the root of Dahurain angelica and the peppermint way of distillation are vaporized, the white crystals that collection is obtained are dried to powder, It is standby.

9. the preparation method of the Chinese medicine preparation of acne is treated according to claim 7, it is characterised in that In the step d, two kinds of medicines of extraction that the white crystalline powder input above-mentioned steps that will be collected into are obtained In liquid, stir, heat, mediation matrix, into gel；The matrix is selected from：Tween-80, Triethanolamine, propane diols, in semi-synthetic fatty glyceride, poloxamer, polyethylene glycol, lanolin One or more.