CN106420556A - Toothpaste containing bio-additives and preparation method of toothpaste - Google Patents
Toothpaste containing bio-additives and preparation method of toothpaste Download PDFInfo
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- CN106420556A CN106420556A CN201610858498.4A CN201610858498A CN106420556A CN 106420556 A CN106420556 A CN 106420556A CN 201610858498 A CN201610858498 A CN 201610858498A CN 106420556 A CN106420556 A CN 106420556A
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- toothpaste
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Insects & Arthropods (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a toothpaste containing bio-additives and a preparation method of the toothpaste, and belongs to the technical field of processing of daily chemical products. The toothpaste consists of the following components in parts by weight: 5-10 parts of keratin powder, 5-10 parts of diatom ooze, 50-70 parts of a moisturizer, 10-20 parts of a shaddock peel extracting solution, 1-3 parts of shell-lac, 1-5 parts of a surfactant, 1-2 parts of a thickener, 1-2 parts of a sweetening agent and 1-2 parts of a preservative. According to the toothpaste provided by the invention, by adding active ingredients in shaddock peel to the toothpaste, a clear cleaning effect is guaranteed, and in addition, effects of diminishing inflammation and resisting bacteria are achieved; the keratin powder, which is processed from feathers or hairs of poultry or domestic animals, functions as an abrasive in the toothpaste so as to achieve a cleaning effect and to achieve waste utilization; with the adoption of the diatom ooze which has a great amount of nano pores, bad breath can be adsorbed, and meanwhile, the functions of the the abrasive can be achieved; and the shell-lac, as an adhesive, can enhance the stability of the toothpaste body. The prepared toothpaste is good in stability and strong in cleaning capacity, and the toothpaste, after used, can keep teeth clean and white and breath fresh.
Description
【Technical field】
The present invention relates to chemical product processing technique field is and in particular to a kind of toothpaste containing bio-additive and its preparation side
Method.
【Background technology】
Tooth is mainly used in laboratory rodent chow and helps pronunciation, and the integrality of tooth also has very big shadow to the looks of people simultaneously
Ring, because the support of tooth and alveolar bone, Arch width and occluding relation is normal, just the face that can make one and lip and cheek seem
Plentiful.When people are in speech and smile, neat and pure white tooth, just can manifest health and the beauty of people.On the contrary, if tooth
Bow growth is abnormal, and teeth arrangement disorder is uneven, and face will seem inharmonious;If absence of tooth is too many, lip and cheek
Lose support and be recessed, the face that will make one presents a weathered appearance and becomes thin.Therefore protect the shape of tooth and integrality seems outstanding
It is important.
Because people needs by oral cavity dietary intake daily, easily breed bacteria in oral cavity, causes various oral problem, mouth
Chamber problem is attached in dental surface and teeth space mainly due to swill, leads to the amount reproduction of bacterium, bacterial corrosion tooth
Tooth, the secretion of generation forms hard tartar, is difficult to remove, and the gas that the food of bacterium decomposition simultaneously produces causes halitosis, bacterium
Breeding or edible irritable food etc. all can cause swelling and aching of gum, bleeding and oral lesions etc., the oral cavity having a strong impact on people is good for
Health and personal image, the therefore cleaning to tooth and oral cavity, improve oral environment and are very important.
Toothpaste is the cleaning agent of people's daily cleaning tooth, can be attached to the tartar on tooth with effective cleaning, have strong
Tooth protects effect that gum keeps oral cleaning, for various oral problem, often adds various compositions acquisitions in toothpaste and has not
The toothpaste of congenerous, is required with the routine use meeting people.
Animal husbandry is flourishing now, daily the processed production of substantial amounts of meat products, and the hair of poultry and livestock is in process
In go out of use, produce substantial amounts of biologic garbage, cause environmental pollution, animal hair main component is keratin, and its content is up to
More than 80%, keratin has proteolysis resistant performance, and has certain hardness, can play cleaning as the rubbing agent of toothpaste and make
With.
Shellac is that lac insect draws oozy purple natural resin after host tree resin, nontoxic and have certain viscous
Property, it is widely used in chemical industry and food.
【Content of the invention】
It is an object of the invention to:For above-mentioned problem, provide a kind of toothpaste containing bio-additive and its system
Preparation Method, by the angle egg adding pomelo peel extract in toothpaste, the hair of shellac, diatom ooze and poultry or livestock processes
White powder, the lotion of toothpaste of preparation is stable, and cleaning dirt-removing power is strong, has the effect of bad air in absorption oral cavity simultaneously, uses
Teeth whitening afterwards, breath freshening.
To achieve these goals, the technical solution used in the present invention is as follows:A kind of toothpaste containing bio-additive, including
The component of following parts by weight:Keratin powder 5-10 part, diatom ooze 5-10 part, NMF 50-70 part, pomelo peel extract 10-
20 parts, shellac 1-3 part, surfactant 1-5 part, thickener 1-2 part, sweetener 1-2 part and preservative 1-2 part.
Described keratin powder by livestock or poultry hair is sterilized, cleaning, dry and grind after the powder that is prepared from.
Described pomelo peel extract is to be immersed in after blending in the water of 1-1.5 times of weight by shaddock green-skinned, through anti-
Multiple freeze-thaw squeezes after processing, filters, and adds the liquid that the dietary alkali that percentage by weight is 1-2% obtains.
The hair of described poultry or livestock is one of chicken feather, drake feather, goose feather, pig hair and ox hair or two or more combinations
Thing.
Described NMF includes one of glycerine, sorbierite and polyethylene glycol or two or more compositions.
Described surfactant is sodium lauryl sulfate or 2- acyloxy key sodium sulfonate.
Described thickener includes carboxymethylcellulose calcium, deer horn pectin, hydroxyethyl cellulose, xanthans, guar gum and angle fork
One of glue or two or more compositions.
Described sweetener is cyclohexylamine sulfonic acid sodium and/or saccharin sodium.
Described preservative is sorbic acid sylvite and/or Sodium Benzoate.
Present invention also offers a kind of preparation method of the toothpaste containing bio-additive, comprise the steps:
(1) pomelo peel is removed white portion and take shaddock green-skinned;It is immersed in 1-1.5 after shaddock green-skinned is blended
In the water of times weight, under conditions of -50 DEG C to -20 DEG C, freeze 40-60 minute, take out defrosting 15- in 40-60 DEG C of water-bath
30 minutes, after freeze-thaw processes 3-4 time repeatedly, squeezing, filtration, add the dietary alkali stirring that percentage by weight is 1-2%
So that it is fully dissolved, obtain final product pomelo peel extract;
(2) hair of poultry or livestock is immersed in 3% Hydrogen Peroxide Disinfection Solution of its 2-5 times of volume, soaks 0.5-1
Hour, rinse well, dry and grind into powder, as keratin powder;
(3) 1-3 part shellac is dispersed in 50-70 part NMF, at 75-80 DEG C, stirs 1-2 hour, add 1-5 part
Surfactant, stirring makes it be uniformly dispersed, and sequentially adds 10-20 pomelo peel extract, 1-2 part thickening after being cooled to room temperature
Agent, 1-2 part sweetener and 1-2 part preservative, mix and blend 0.5-1 hour at room temperature, add 5-10 part keratin powder and 5-
10 parts of diatom oozes, are stirred at room temperature 1-2 hour, transfer to grinding machine for grinding 1-2 hour, obtain sticky exquisiteness lotion, that is,
Tooth for the present invention
In sum, due to employing technique scheme, the invention has the beneficial effects as follows:
(1) present invention is extracted to the active ingredient in pomelo peel by multiple freezing repeatedly, defrosting and expressing process,
So that the cell membrane in pomelo peel is destroyed, its active ingredient fully leaches, improve the recovery rate of pomelo peel extract;Simultaneously
Add dietary alkali, dietary alkali can be reacted with grease makes it become material soluble in water, plays the role of oil stain;By preparation
Pomelo peel extract is added in toothpaste, improves the cleaning capacity of toothpaste;
(2) keratin powder has the performance of proteolysis resistant and hardness is moderate, can be added in toothpaste to become as rubbing agent
Point, play cleaning action, the present invention is replaced by the use of the keratin powder of the hair preparation of poultry or livestock as bio-additive part
Conventional friction agent, less to the frictionally damage of tooth and gum, effectively prevent tooth wear and bleeding gums, be simultaneously achieved useless
Thing utilizes, environmental protection;
(3) contain substantial amounts of nanometer micropore in diatom ooze, can effectively adsorb the peculiar smell in oral cavity, be also used as rubbing
Agent, has the effect improving implication and cleaning tooth;
(4) shellac can improve the stability of lotion as the binding agent of toothpaste.
The toothpaste good stability of present invention preparation, cleaning capacity is strong, and friction component is soft, to tooth and gingival lesions
Little, using rear teeth whitening, breath freshening.
【Specific embodiment】
With reference to specific embodiment, technical scheme is made with the explanation carrying out further.
Embodiment 1
(1) pomelo peel is removed white portion and take shaddock green-skinned;It is immersed in 1 times of weight after shaddock green-skinned is blended
In the water of amount, freezing under the conditions of -50 DEG C was taken out after 40 minutes, thawed 15 minutes in 60 DEG C of water-bath, freeze-thaw repeatedly
After processing 3 times, squeezing, filtration, add the dietary alkali that percentage by weight is 1%, stirring makes it fully dissolve, obtains final product pomelo peel
Extract;
(2) chicken feather is immersed in 3% Hydrogen Peroxide Disinfection Solution of its 2 times of volumes, soaks 1 hour, rinse well, dry
Dry doubling grind into powder, as keratin powder;
(3) 1 part of shellac is dispersed in 50 parts of glycerine, stirs 2 hours at 75 DEG C, add 5 parts of sodium lauryl sulfates to stir
Mix and so that it is uniformly dispersed, be cooled to room temperature and sequentially add 20 pomelo peel extracts, 2 parts of carboxymethylcellulose calciums, 1 part of cyclohexylamine sulfonic acid
Sodium and 1 part of sorbic acid sylvite, are stirred at room temperature 0.5 hour, add 10 parts of keratin powders and 10 parts of diatom oozes, stir at room temperature
Mix 2 hours, transfer to grinding machine for grinding 2 hours, obtain sticky exquisiteness lotion, the as toothpaste of the embodiment of the present invention.
In the embodiment of the present invention, also choosing 50 respectively has bleeding gums and the patient of implication to use the embodiment of the present invention
Toothpaste, as shown in table 1 using statistics after 5 days.
Table 1:Choose the effect that 50 patients having bleeding gums and implication use embodiment of the present invention toothpaste respectively
Bleeding gums | Implication | |
Participation number, people | 50 | 50 |
Efficiently individual quantity, people | 43 | 45 |
Invalid number, people | 7 | 5 |
Success rate, % | 0.86 | 0.90 |
Embodiment 2
(1) pomelo peel is removed white portion and take shaddock green-skinned;It is immersed in 1.5 times after shaddock green-skinned is blended
In the water of weight, freeze 60 minutes under the conditions of -20 DEG C, take out and thaw 30 minutes in 40 DEG C of water-bath, freeze-thaw repeatedly
After processing 4 times, squeezing, filtration, add the dietary alkali that percentage by weight is 2%, stirring makes it fully dissolve, obtains final product pomelo peel
Extract;
(2) pig hair is immersed in 3% Hydrogen Peroxide Disinfection Solution of its 5 times of volumes, soaks 0.5 hour, rinse well,
Dry and grind to form fine powder, as keratin powder;
(3) 3 parts of shellac are dispersed in 70 parts of polyethylene glycol, stir 1 hour at 80 DEG C, add 2 parts of 2- acyloxy keys
Sodium sulfonate stirring makes it be uniformly dispersed, and is cooled to room temperature and sequentially adds 10 pomelo peel extracts, 1 portion of hydroxyethyl cellulose, 2 portions of sugar
Smart sodium and 2 parts of Sodium Benzoates, are stirred at room temperature 1 hour, add 5 parts of keratin powders and 5 parts of diatom oozes, are stirred at room temperature 1
Hour, transfer to grinding machine for grinding 1 hour, obtain sticky exquisiteness lotion, the as toothpaste of the embodiment of the present invention.
In the embodiment of the present invention, also choosing 50 respectively has bleeding gums and the patient of implication to use the embodiment of the present invention
Toothpaste, as shown in table 2 using statistics after 5 days.
Table 2:Choose the effect that 50 patients having bleeding gums and implication use embodiment of the present invention toothpaste respectively
Bleeding gums | Implication | |
Participation number, people | 50 | 50 |
Efficiently individual quantity, people | 40 | 40 |
Invalid number, people | 10 | 10 |
Success rate, % | 0.80 | 0.80 |
Embodiment 3
(1) pomelo peel is removed white portion and take shaddock green-skinned;It is immersed in 1.2 times after shaddock green-skinned is blended
In the water of weight, freeze 50 minutes under the conditions of -40 DEG C, take out and thaw 20 minutes in 50 DEG C of water-bath, freeze-thaw repeatedly
After processing 4 times, squeezing, filtration, add the dietary alkali that percentage by weight is 1.5%, stirring makes it fully dissolve, obtains final product shaddock
Skin extract;
(2) drake feather is immersed in 3% Hydrogen Peroxide Disinfection Solution of its 4 times of volumes, soaks 0.8 hour, rinse well,
Dry and grind to form fine powder, as keratin powder;
(3) 2 parts of shellac are dispersed in 60 parts of sorbierites, stir 1.5 hours at 80 DEG C, add 3 parts of 2- acyloxy keys
Sodium sulfonate stirring makes it be uniformly dispersed, and is cooled to room temperature and sequentially adds 15 pomelo peel extracts, 2 parts of deer horn pectin, 1 part of saccharin sodium
With 2 parts of Sodium Benzoates, it is stirred at room temperature 1 hour, add 8 parts of keratin powders and 7 parts of diatom oozes, be stirred at room temperature 1.5 little
When, transfer to grinding machine for grinding 1.5 hours, obtain sticky exquisiteness lotion, the as toothpaste of the embodiment of the present invention.
In the embodiment of the present invention, also choosing 50 respectively has bleeding gums and the patient of implication to use the embodiment of the present invention
Toothpaste, as shown in table 3 using statistics after 5 days.
Table 3:Choose the effect that 50 patients having bleeding gums and implication use embodiment of the present invention toothpaste respectively
Bleeding gums | Implication | |
Participation number, people | 50 | 50 |
Efficiently individual quantity, people | 45 | 48 |
Invalid number, people | 5 | 2 |
Success rate, % | 0.90 | 0.96 |
Use result from various embodiments of the present invention, the lotion of toothpaste of the present invention is fine and smooth stable, using the tooth of the present invention
Cream, obvious to bleeding gums and implication problem improvement.
Described above is the detailed description for the preferable possible embodiments of the present invention, but embodiment is not limited to this
Bright patent claim, the equal change being completed under the technical spirit suggested by all present invention or modification change, all should belong to
In the covered the scope of the claims of the present invention.
Claims (9)
1. a kind of toothpaste containing bio-additive is it is characterised in that include the component of following parts by weight:Keratin powder 5-10
Part, diatom ooze 5-10 part, NMF 50-70 part, pomelo peel extract 10-20 part, shellac 1-3 part, surfactant 1-5 part,
Thickener 1-2 part, sweetener 1-2 part and preservative 1-2 part;
Described keratin powder be by livestock or poultry hair is sterilized, cleaning, dry and grind after the powder that is prepared from.
2. the toothpaste containing bio-additive according to claim 1 is it is characterised in that described pomelo peel extract is by shaddock
Sub- green-skinned is immersed in the water of 1-1.5 times of weight after blending, squeezing, filtration after processing through freeze-thaw repeatedly, then plus
Enter the liquid that the dietary alkali that percentage by weight is 1-2% obtains.
3. the toothpaste containing bio-additive according to claim 1 is it is characterised in that the hair of described poultry or livestock is chicken
One of hair, drake feather, goose feather, pig hair and ox hair or two or more compositions.
4. the toothpaste containing bio-additive according to claim 1 is it is characterised in that described NMF includes glycerine, mountain
One of pears alcohol and polyethylene glycol or two or more compositions.
5. the toothpaste containing bio-additive according to claim 1 is it is characterised in that described surfactant is lauryl alcohol
Sodium sulphate or 2- acyloxy key sodium sulfonate.
6. the toothpaste containing bio-additive according to claim 1 is it is characterised in that described thickener includes carboxymethyl fibre
One of dimension element, deer horn pectin, hydroxyethyl cellulose, xanthans, guar gum and carrageenan or two or more compositions.
7. the toothpaste containing bio-additive according to claim 1 is it is characterised in that described sweetener is cyclohexylamine sulfonic acid
Sodium and/or saccharin sodium.
8. the toothpaste containing bio-additive according to claim 1 is it is characterised in that described preservative is sorbic acid sylvite
And/or Sodium Benzoate.
9. a kind of preparation method of the toothpaste containing bio-additive described in any one of claim 1 to 8 is it is characterised in that wrap
Include following steps:
(1) pomelo peel is removed white portion and take shaddock green-skinned;It is immersed in 1-1.5 times after shaddock green-skinned is blended to weigh
In the water of amount, under conditions of -50 DEG C to -20 DEG C, freeze 40-60 minute, take out defrosting 15-30 in 40-60 DEG C of water-bath and divide
Clock, after freeze-thaw processes 3-4 time repeatedly, squeezing, filtration, adding the dietary alkali stirring that percentage by weight is 1-2% makes it
Fully dissolve, obtain final product pomelo peel extract;
(2) hair of poultry or livestock is immersed in 3% Hydrogen Peroxide Disinfection Solution of its 2-5 times of volume, soaks 0.5-1 individual little
When, rinse well, dry and grind into powder, as keratin powder;
(3) 1-3 part shellac is dispersed in 50-70 part NMF, at 75-80 DEG C, stirs 1-2 hour, add 1-5 part surface
Activating agent, stirring makes it be uniformly dispersed, and sequentially adds 10-20 pomelo peel extract, 1-2 part thickener, 1-2 after being cooled to room temperature
Part sweetener and 1-2 part preservative, mix and blend 0.5-1 hour at room temperature, add 5-10 part keratin powder and 5-10 part silicon
Algae mud, is stirred at room temperature 1-2 hour, transfers to grinding machine for grinding 1-2 hour, obtains sticky exquisiteness lotion, is this
Bright toothpaste.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115531239A (en) * | 2022-05-19 | 2022-12-30 | 海默斯(重庆)医学生物技术有限公司 | Nano-particles, toothpaste and preparation method thereof |
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CN102586023A (en) * | 2012-01-19 | 2012-07-18 | 仲恺农业工程学院 | Method for extracting essential oil from citrus peels |
CN102703219A (en) * | 2012-04-19 | 2012-10-03 | 华南理工大学 | Pomelo peel essential oil extraction method by peel icing and breaking |
CN104780901A (en) * | 2012-11-08 | 2015-07-15 | 狮王株式会社 | Oral composition |
CN105816345A (en) * | 2016-04-20 | 2016-08-03 | 青岛大学附属医院 | Functional toothpaste preparation for preventing and treating periodontitis |
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2016
- 2016-09-27 CN CN201610858498.4A patent/CN106420556A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1599592A (en) * | 2001-10-02 | 2005-03-23 | 荷兰联合利华有限公司 | Oral composition comprising fine ground natural chalk |
CN102586023A (en) * | 2012-01-19 | 2012-07-18 | 仲恺农业工程学院 | Method for extracting essential oil from citrus peels |
CN102703219A (en) * | 2012-04-19 | 2012-10-03 | 华南理工大学 | Pomelo peel essential oil extraction method by peel icing and breaking |
CN104780901A (en) * | 2012-11-08 | 2015-07-15 | 狮王株式会社 | Oral composition |
CN105816345A (en) * | 2016-04-20 | 2016-08-03 | 青岛大学附属医院 | Functional toothpaste preparation for preventing and treating periodontitis |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN115531239A (en) * | 2022-05-19 | 2022-12-30 | 海默斯(重庆)医学生物技术有限公司 | Nano-particles, toothpaste and preparation method thereof |
CN115531239B (en) * | 2022-05-19 | 2023-12-12 | 海默斯(重庆)医学生物技术有限公司 | Nanoparticle, toothpaste and preparation method thereof |
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