CN106389139A - Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof - Google Patents

Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof Download PDF

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Publication number
CN106389139A
CN106389139A CN201611027865.2A CN201611027865A CN106389139A CN 106389139 A CN106389139 A CN 106389139A CN 201611027865 A CN201611027865 A CN 201611027865A CN 106389139 A CN106389139 A CN 106389139A
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China
Prior art keywords
acid
acne
eliminating
removing acne
skin
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CN201611027865.2A
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Chinese (zh)
Inventor
赵永亮
王卫国
靳松峰
解邦杰
裴占柱
胡晓伟
林强
陶宜辰
王丽洁
苑旺
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Henan University of Technology
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Henan University of Technology
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Priority to CN201611027865.2A priority Critical patent/CN106389139A/en
Publication of CN106389139A publication Critical patent/CN106389139A/en
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Abstract

The invention discloses an acne-removing, mark-eliminating and skin-protecting multifunctional preparation with both acne-removing and mark-eliminating effects and skin-beautifying and skin-protecting effects and a preparation method thereof. The acne-removing, mark-eliminating and skin-protecting multifunctional preparation is composed of a skin care composition, an acne-removing and mark-eliminating composition and a solvent, and not only contains collagen, vitamins and other various nutrients required for normal skin nutrition, but also contains a coenzyme I, a coenzyme II, nicotinamide, a coenzyme Q10 and other healthcare components required for skin health maintenance. The acne-removing, mark-eliminating and skin-protecting multifunctional preparation not only has disinfection, anticorrosion and anti-bacterium components, but also has injured tissue repair components, and the effective combination of the multiple components can generate mild acne-removing and mark-eliminating effects; the acne-removing, mark-eliminating and skin-protecting multifunctional preparation has the advantages of being high in safety, convenient to use, wide in application range, excellent in effect and the like. The acne-removing, mark-eliminating and skin-protecting multifunctional preparation disclosed by the invention is non-toxic, free from irritation and allergy and almost suitable for all people. The preparation method of the acne-removing, mark-eliminating and skin-protecting multifunctional preparation, disclosed by the invention, has the advantages of mild condition, no need of temperature rise, low energy consumption, simple and short process flow and no environmental pollution, and is a green manufacturing technology that is worth of being popularized.

Description

A kind of removing acne and eliminating mark skin care multifunctional preparation and preparation method thereof
Technical field
The invention belongs to cosmetics and technical field of medicine, relate in particular to a kind of removing acne and eliminating mark skin care multi-functional Preparation and preparation method thereof.
Background technology
Acne is being commonly called as of acne, is " whelk ", " dark sore " or " acne " again, is due to hair follicle and sebum adenemphraxis, sends out A kind of skin disease that inflammation is caused.The generation of acne is main to be blocked with hypersteatosis, pilosebaceous duct, bacterium infection Closely related with factors such as inflammatory reactions.Acne（Whelk）Main clinical manifestation be blackhead, Whiteheads, inflammatory mound Rash, warts, tubercle, tumour, easily form pigmentation, pore is thick or even scar sample damages.Impact is attractive in appearance not to be said, severe patient can Lead to disfeature, can give people to cause great psychological pressure and mental suffering.Typically speak of the origin cause of formation of acne, be nothing more than diet, Hormone is inharmonious, pressure or heredity, or 3male hormone secretion excessive, fat secretion is excessive, local inflammation, bacterium sense Dye, cross-infection, the effect of pathogenic microorganism-Propiobacterium, immune antiboidy effect, allergic, eat animal tallow and sugar more The gastrointestinal disorders such as group food, indigestion or constipation or skin nursing improper etc. caused by.But no matter which kind of reason, all can return Become：Acne is a large amount of oil substances and the sweat do not removed in time, dust, germ, acarid etc. in hair follicle and sebaceous glands Block the sebaceous glands mouth of skin surface, and then cause multiple pathogenic microorganisms（Especially propionibacterium acnes）Amount reproduction is formed Inflamed papules, warts, multiple scytitises such as tubercle and tumour.
At present, conventional anti-acne method or product are mainly：1st, medicine method：It is divided into external application and oral 2 classes again.Common drug Have：Tretinoin, antibioticses（Clindamycin, erythromycin, chloramphenicol etc.）, sulphur lotion etc.；Anti-androgens；Oral glucose skin Matter steroids；Chinese medicine class etc.；2nd, Physical：As laser anti-acne art etc..Though medicine method can anti-acne, some poisonous side effect of medicine Greatly, some effects are undesirable, and most product for resolving poxes be mostly add substantial amounts of oil substances or silicone oil and other have latent In the organic solvent endangering as matrix and solvent；Although the Physicals such as laser anti-acne art disappear, preferably, this is a kind of to acne effect Operative treatment, not only performs the operation and inherently can limit the people that a part is unable to undergo to perform the operation, and also a lot of contraindications, such as pregnant woman, Photosensitization person, to photaesthesia person and used photosensitizer（Retinoid, tetracycline etc.）People, hypertension, diabetic, Long-term taking some antipsychotics person, take antiphlogistic, depressor person, the person that has solar exposure in two weeks, have inflammation person on face （The people's majority going out acne has inflammation, because a kind of diseases associated with inflammation that acne inherently inflammation is caused）, to operation desired value Too high person is it is not recommended that do.
In addition, the current all methods producing or preparing anti-acne class product mostly be unable to do without heating（At least it is greater than 60 DEG C） This unit operates.And heat and not only consume energy and be unfavorable for greatly environmental protection, for safeguarding the life to heat sensitivity component in product for resolving poxes Reason activity or effect are also unfavorable.
Content of the invention
For solving defect or the deficiency of above-mentioned technology or product, the invention provides a kind of multi-functional system of removing acne and eliminating mark skin care Agent and preparation method thereof.
The basic ideas of the present invention are first on the premise of ensureing drug safety and skin safe, by common multiple Acne class thing Producing reason and the parsing of acne body structure, both need to protect based on patient skin, with greater need for anti-acne, anti-acne and reparation The theory laid equal stress on protection, screening has nutrition and health care and acts on and belong to biogenic or biochemical class, food-borne to skin , component based on the component of clear efficacy, with generally acknowledge have the derivatives such as salicylic acid and its salt of broad-spectrum high efficacy safety, Sorbic acid and its salt, glycyrrhizic acid or/and its esters, urea etc. as main disinfection and exfoliating composition, according to skin group Knit and different material is absorbed or the understanding through rule characteristic and analysis with cell, without tradition tool toxic and side effect or excitant In the case of medicine, the biogenic or biochemical class component to skin with nutrition and health care effect and removing acne and eliminating mark effect are entered Row science assembles one group of optimization and not only can protect with skin nutrition but also can combine disappear the gentle of safe multiple-effect of scar pockmark of anti-acne Thing, then it is made into the skin care removing acne and eliminating mark product formulation of Energy and comfort using certain technology method.
It is an object of the invention to provide a kind of removing acne and eliminating mark skin care multifunctional preparation and preparation method thereof.The present invention dispels Acne disappears the existing obvious removing acne and eliminating mark effect of trace skin conditioner, and the nutritious effect with protection skin, collection removing acne and eliminating mark and nutrition It is integrated with protection skin.This removing acne and eliminating mark skin conditioner is to be made up of skin care composition, removing acne and eliminating mark composition and solvent. This removing acne and eliminating mark skin conditioner contains the hyaluronic acid of high, normal, basic three kinds of different molecular weight sizes or/and hyaluronate, high, normal, basic The polyglutamic acid of three kinds of different molecular weight sizes or/and polyglutamate, glutamic acid or/and glutamate, collagen, collagen Protein peptides, Vc, Ve, Vb5, nicotinic acid, niacinamide, DPN, DPN I, chondroitin sulfate, taurine, liquaemin, ubiquinone10, sea Algae sugar, sodium alginate, xanthans, sorbic acid and its esters, glycyrrhizic acid or/and its esters, salicylic acid or/and salt, acetyl water Sour, the smart ammonia acetylsalicylic acid of poplar, lysine acetylsalicylate, calcium acetylsalicylate urea, urea, allantoin, lactic acid, lactate, apple Tartaric acid, tartaric acid, citric acid, polyethylene glycol, glycerine, ethanol, water.Removing acne and eliminating mark skin conditioner of the present invention is easy to use comfortable, effect Fruit is notable, and the easy simultaneously environmental sound of fabricating technology method.
The present invention is realized in：
The present invention provides a kind of removing acne and eliminating mark skin care multifunctional preparation.The removing acne and eliminating mark skin conditioner of the present invention is by skin care group Compound, removing acne and eliminating mark composition and solvent are constituted, and wherein, described skin care composition includes high, normal, basic three kinds of different moleculars The hyaluronic acid of amount size or/and hyaluronate, the polyglutamic acid of high, normal, basic three kinds of different molecular weight sizes or/and polyglutamic Hydrochlorate, glutamic acid or/and glutamate, collagen, collagen peptide, Vc, Ve, Vb5, nicotinic acid, niacinamide, DPN, coenzyme II, chondroitin sulfate, taurine, liquaemin, ubiquinone10, trehalose, sodium alginate, xanthans；Described removing acne and eliminating mark combination Thing include sorbic acid and its esters, glycyrrhizic acid or/and its esters, urea, allantoin, lactic acid, lactate, malic acid, tartaric acid, Citric acid and salicylic acid or/and salt, acetylsalicylic acid, Arginine Acetylsalicylate, lysine acetylsalicylate, aspirin Arbitrary or a combination thereof in calcium urea；Described solvent contains grape wine, polyethylene glycol, lactic acid, glycerine, second alcohol and water；Without In the case of tradition tool toxic and side effect or dripping of irritant drugs, by above-mentioned skin care composition, removing acne and eliminating mark composition and solvent The science of carrying out assembles and optimizes, then is made into the removing acne and eliminating mark skin conditioner agent of Energy and comfort using certain technology method Type.Removing acne and eliminating mark skin conditioner of the present invention is easy to use comfortable, effect is significant, and fabricating technology method is simple and to environment no Evil.
The quality proportioning of skin care composition of the present invention, removing acne and eliminating mark composition and solvent three is：0.1～ 98.00: 0.2～99.00: 0.1～99.70；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and hyaluronate 0.1-5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-8.0, low-molecular-weight Hyaluronic acid or/and hyaluronate 0.1-10.0, the polyglutamic acid of HMW or/and polyglutamate 0.1-4.0, in point The polyglutamic acid of son amount or/and polyglutamate 0.1-6.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1- 12.0th, collagen 0.01-10.0, collagen peptide 0.01-8.0, Vc 0.01-5.0, Ve 0.01-5.0, Vb50.01- 8.0th, nicotinic acid 0.01-5.0, niacinamide 0.01-5.0, DPN 0.01-2.0, DPN I 0.01-2.0, chondroitin sulfate 0.01-5.0, taurine 0.01-5.0, liquaemin 0.01-5.0, ubiquinone100.01-5.0, trehalose 0.01-9.0, alginic acid Sodium 0.01-9.0, xanthans 0.01-9.0；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its esters 0.001- 4.0th, glycyrrhizic acid or/and its esters 0.001-4.0, urea 0.01-15.0, allantoin 0.01-15.0, lactate 0.01-5.0, Citric acid 0.01-5.0, malic acid 0.01-8.0, tartaric acid 0.01-8.0 and salicylic acid or/and its esters 0.001-35.0, second Acyl salicylic acid 0.001-25.0, Arginine Acetylsalicylate 0.002-30.0, lysine acetylsalicylate 0.002-40.0, A Si Arbitrary or a combination thereof in woods calcium urea 0.002-40.0；
Solvent of the present invention is by following mass percent（%）Raw material constitute：Grape wine 0.0001-40.0, polyethylene glycol 0.0001-15.0, lactic acid 0.01-5.0, glycerine 0.0001-10.0, ethanol 0.0001-50.0 and water 0.01-99.9.
As a kind of preferred embodiment of this removing acne and eliminating mark skin conditioner, skin care combination in described removing acne and eliminating mark skin conditioner The quality proportioning of thing, removing acne and eliminating mark composition and solvent three is：0.2～98.00: 0.3～99.00: 0.1～99.50；Its In, described skin care composition presses following mass percent（%）Raw material composition：The hyaluronic acid of HMW or/and The hyaluronic acid of hyaluronate 0.1-3.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-6.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 0.1-8.0, HMW or/and polyglutamate 0.1-3.0, middle-molecular-weihydroxyethyl poly- Glutamic acid or/and polyglutamate 0.1-5.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1-6.0, collagen egg White 0.1-8.0, collagen peptide 0.1-6.0, Vc 0.1-4.0, Ve 0.1-4.0, Vb50.1-6.0, nicotinic acid 0.05-3.0, cigarette Acid amides 0.05-3.0, DPN 0.05-1.0, DPN I 0.05-1.0, chondroitin sulfate 0.1-3.0, taurine 0.1-2.0, Liquaemin 0.1-2.0, ubiquinone100.1-3.0, trehalose 0.1-5.0, sodium alginate 0.1-5.0, xanthans 0.1-5.0；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 0. 01-2.0, Glycyrrhizic acid or/and its esters 0.01-3.0, urea 0.1-10.0, allantoin 0.1-8.0, lactate 0.1-3.0, citric acid 0.1- 3.0th, malic acid 0.1-5.0, tartaric acid 0.1-5.0 and salicylic acid or/and its esters 0.01-20.0, acetylsalicylic acid 0.01- 19.0th, Arginine Acetylsalicylate 0.02-25.0, lysine acetylsalicylate 0.02-30.0, calcium acetylsalicylate urea 0.02- Arbitrary or a combination thereof in 30.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.01-25.0, polyethylene glycol 0.01- 10.0th, lactic acid 0.1-3.0, glycerine 0.01-5.0, ethanol 0.01-30.0 and water 0.1-98.5.
Except minority belongs to biological endogenous property or the derivative beyond the region of objective existence of biochemical class component in the removing acne and eliminating mark skin conditioner component of the present invention, Other is biological endogenous property, food-borne, clear efficacy component, and wherein, some still constitute skin histology and cell Basis, and, most components have multiple physiology/pharmacological functions or effect.As hyaluronic acid, polyglutamic acid, Collagen, collagen peptide, Vc, Ve, Vb5, nicotinic acid, niacinamide, DPN, DPN I, chondroitin sulfate, taurine, liver Element, lactic acid, lactate, ubiquinone10It is with water and constitute the basis of skin histology and cell or maintain normal skin tissue Carry out biogenic physiologically active ingredient with cell, meanwhile, they also have anti-aging and moisturizing, anti-oxidant with carry High skin immunity, antiallergy etc. act on；Glycyrrhizic acid or/and its esters, urea, allantoin, lactate, citric acid, malic acid, Tartaric acid and salicylic acid or/and salt, acetylsalicylic acid, smart ammonia acetylsalicylic acid, lysine acetylsalicylate, calcium acetylsalicylate Urea, then in anti-corrosion, sterilization, removing acne and eliminating mark, cutin-softening, to dispel the aspects such as cutin respond well, each group is divided and is dispelled with the use of it The acne trace effect that disappears is more significantly and rapid；Trehalose and sodium alginate have protection Skin Cell and radiation-resistant work(under adverse circumstance Energy；Xanthans then has good thickening, attachment and lubrication；Sorbic acid and its esters are well recognized as safe food-level antibacterial Preservative, is conducive to keeping long-time stability and the quality of product.Said components are carried out science assemble and optimize, using this Bright described solvent, can be prepared using certain technology method and can disappear in the case of no any wound and misery Preparation except stupid acne.
The hyaluronic acid of high, normal, basic three kinds of different molecular weight sizes in removing acne and eliminating mark skin conditioner of the present invention or/ Refer to that polymer hyaluronic acid or the molecular weight of hyaluronate are more than 1,800,000 dalton, middle molecule with hyaluronate The molecular weight of hyaluronic acid or hyaluronate between 1,000,000-1,800,000 dalton, low molecular weight hyaluronic acid Or the molecular weight of hyaluronate is less than 600,000 dalton.
The polyglutamic acid of described high, normal, basic three kinds of different molecular weight sizes or/and polyglutamate refer to macromolecule polyglutamic The molecular weight of acid or polyglutamate is more than 1,000,000 dalton, the molecular weight of middle molecule polyglutamic acid or polyglutamate Between 600,000-1,000,000 dalton, the molecular weight of low molecular weight polycaprolactone glutamic acid or polyglutamate is less than 100,000 Dalton.
Grape wine in described solvent includes red wine and white wine；Preferably, it is that extra dry red wine, half extra dry red wine and half are sweet red And extra dry white wine, medium dry white wine and half are sweet white；Polyethylene glycol refers to that the molecular weight of more than food-grade is appointing in 200-20000 dalton One kind or a combination thereof；Lactic acid, glycerine and ethanol are more than food-grade；Water is the above pure water of counter-infiltration level or its distilled water.
In the removing acne and eliminating mark skin conditioner of the present invention, all components are the product of more than commercially available food-grade or medical grade Product；In addition to above-mentioned composition and solvent, tradition can be adopted as suitably desired to allow the no safe of use in skin care item Hidden danger composition or additive or carrier or auxiliary material.For example, other whitening agents, NMF, antioxidant, surfactant, alcohol The materials such as class, water.
The removing acne and eliminating mark skin conditioner formulation of Energy and comfort of the present invention includes liquid formulation and solid formulation, and preferably half Fluidised form preparation, more preferably water gelling agent；In practical application, can as needed and use Energy and comfort, with In described removing acne and eliminating mark skin conditioner, composition in addition to the solvents is base-material, then it is acceptable to mix removing acne and eliminating mark skin conditioner of the present invention Carrier or auxiliary material, the convenient various formulations being suitable for are made using corresponding preparations technology, can be aqua, vina, tincture, suspended Liquid, emulsion, creme, paste, gel, coagulant liquid, finish, film, spray or patch etc..
Present invention also offers the preparation method of above-mentioned removing acne and eliminating mark skin conditioner, comprise the steps：
（1）Formula as described in this patent and formula ratio weigh each component of skin care and removing acne and eliminating mark composition respectively, standby With；
（2）Formula as described in this patent and formula ratio weigh each component of this removing acne and eliminating mark skin conditioner solvent for use respectively, often Standby after temperature or low temperature mixing；
（3）Each component of the skin care composition of formula ratio is added solvent, normal temperature or the low temperature of part formulation amount Mix, obtain mixture A；
（4）Each component of the removing acne and eliminating mark composition of formula ratio is added solvent, normal temperature or the low temperature of part formulation amount Mix, obtain mixture B；
（5）Mixture B is slowly added in mixture A, then residual solvent is added thereto, normal temperature or low temperature are equal Even, obtain final product described removing acne and eliminating mark skin conditioner.
Step（2）（3）（4）（5）Described in normal temperature or cryogenic conditions be preferably less than 42 DEG C, again more preferably less than 21 DEG C But it is more than 10 DEG C.
Step（2）（3）（4）（5）Described in stir and evenly mix operating condition be preferably in medical stainless steel blender Two-dimentional mix and blend, more preferably in glass reactor or 316L stainless steel blender three-dimensional hybrid stirring, further preferably for Emulsifying mode under vacuum is realized.
In practical operation, can as needed and use Energy and comfort, with above-mentioned removing acne and eliminating mark skin conditioner be Base-material, then mix removing acne and eliminating mark skin conditioner acceptable carrier of the present invention or auxiliary material, using the corresponding preparations technology side of making Just the various formulations being suitable for.
The present invention, compared with traditional removing acne and eliminating mark method or technique, has following features：
（1）The physiological and pathological life of chemical composition, skin biochemistry and skin physiology characteristic and each vaccination according to skin Change characteristic and based on the theory of anti-acne skin care again comprehensive prescription design should be carried out；
（2）On removing acne and eliminating mark skin conditioner raw material components select, based on the consideration of security first principle, skin used by the present invention Maintenance raw material belongs to biological endogenous property or the derivative beyond the region of objective existence of biochemical class component except minority, and other is biological endogenous property, biochemical class , food-borne, clear efficacy component, these compositions are mostly natively to have in skin histology or body, only because With advancing age or other reason causes its content not enough or deficient and so that skin or body immunity is declined and become disease The susceptible person of substance, wherein, some still constitute the basis of skin histology and cell, and, most components have Multiple physiology/pharmacological functions simultaneously have good protective effect to skin.So, both provided for skin tissue cell enough Component needed for nutrition, has the function of multiple protective skin again；
（3）It is based on and removing acne and eliminating mark should also want skin friendly or toxic and side effect or irritating former is not produced to body or skin Then, on removing acne and eliminating mark raw material components select, existing sterilization anti-corrosive antibacterial antipathogenic composition, have again and repair damaged tissues composition, two The efficient combination of person can produce gentle removing acne and eliminating mark effect；Especially with the using cooperatively of skin care composition, gentle anti-acne The trace that disappears effect is more notable；
（4）The solvent of the present invention is unique, is to be made up of various ingredients such as grape wine, polyethylene glycol, lactic acid, glycerine, second alcohol and waters, Both can dissolve water-soluble component, also can dissolve water-msoluble ingredients, such solvent constitute can ensure that raw materials used wherein There is good dissolubility；
（5）The preparation method mild condition of removing acne and eliminating mark skin conditioner of the present invention, process is simple, non-environmental-pollution.Due to the present invention Raw materials used mostly be biochemical class component, more sensitive to physical and chemical factors such as high temperature and illumination, so, by component preferably and technique Optimize, establish a kind of process is simple, no environment that can prepare removing acne and eliminating mark skin conditioner of the present invention under normal temperature or low temperature The technical method of pollution；
（6）By the optimum organization of formula and gentle process of preparing using not only successfully solving in this patent prescription Labile active ingredient such as Vc etc. easily decomposes, oxidizable, allochroic problem, also solves various active composition and mixes The various stability problems being likely to occur, as stable, thermally-stabilised in light etc., and allow each component produce collaborative or synergistic effect；
（7）Removing acne and eliminating mark skin conditioner of the present invention existing anti-acne effect, also skin makeup skin care effect, also can be to the skin near acne Carry out prophylactic disinfection in case its further diffusive transport, its core feature is that have protectiveness to normal skin, and to acne Then there is the depth property dispelled；
（8）This removing acne and eliminating mark skin conditioner can quickly penetrate in acne body portion and its surrounding skin tissue, thoroughly kill or suppression epidermis, Pathogen in corium and subcutaneous tissue cell, and form efficient protective layer in skin surface, prevent the invasion and attack again of pathogen And infection, and can deep layer nourishes rough skin.
Long-term result of practical application shows, the present invention has the advantages that in a large number：
（1）Removing acne and eliminating mark is gentle, hurtless measure no pain.In the formula of this removing acne and eliminating mark skin conditioner, become containing multiple foster skin skin cares Point if hyaluronic acid, collagen, vitamin etc. are it is ensured that skin friendly while removing acne and eliminating mark；
（2）Easy to use, excellent effect.Only smear acne body 1-3 time daily with this removing acne and eliminating mark skin conditioner, 2 days take effect, and are within 2 weeks One course for the treatment of, the 3-5 course for the treatment of can thoroughly eliminate stupid acne, and does not stay scar, also user's fitness skin；
（3）Safe, widely applicable.Removing acne and eliminating mark skin conditioner of the present invention is nontoxic, non-stimulated, no allergy is it is adaptable to almost institute There is crowd；
（4）Simple production process, production cost is relatively low；
（5）The preparation method mild condition of removing acne and eliminating mark skin conditioner of the present invention, need not heat up, energy consumption low, technological process is short, and no Environmental pollution, is a kind of green manufacture technology being worthy to be popularized.
The trial effect of people volunteer is as follows：
（1）Case selection：Randomly choose 78 patients, wherein, the male sex 38, women 40, age 14-50 year, average age 25 years old.Selected acne body size differs in size from the grain of rice to pea, extremely even has more than iblet individually big.
（2）Diagnostic criteria：With reference to nineteen ninety-five《People's Republic of China's traditional Chinese medicine industry standard》Judge.Clinical manifestation is black Head acne, Whiteheads, inflamed papules, warts, tubercle, tumour person all have.
（3）Treatment method：Use daily removing acne and eliminating mark skin conditioner spot printing acne body 2-3 time, at least sooner or later each 1 time, if middle use Water-wash away or touch off and need to add 1 time to ensure there is removing acne and eliminating mark skin conditioner all the time on acne body, 1-3 after smearing for the first time, can be massaged Minute to promote to absorb, then again spot printing once to increase dose, 2 days take effect, be within 2 weeks a course for the treatment of, general treatment 2 is treated Journey, according to the state of an illness, acne body bigot can be continuously using the 4-6 course for the treatment of.
（4）Criterion of therapeutical effect：No substantially pockmark person is disappeared for recovery from illness with acne body, the acne body 60-70% that disappears is effective, and acne body disappears It is effective for moving back 40-50%, acne unchanged or disappear less than 10% be invalid.
（5）Treatment results：In 78, fully recover 56, effective 15, effective 6, invalid 1, cure rate 71.8%, effective Rate 19.2%, efficient 7.7%, inefficiency 1.3%, total effective rate 98.7%.
Specific embodiment
With reference to embodiment, the present invention is described in detail：
Embodiment l：
Formula：
In described removing acne and eliminating mark skin conditioner, the quality proportioning of skin care composition, removing acne and eliminating mark composition and solvent three is： 0.10∶0.20∶99.70；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid of hyaluronate 0.1, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 8.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 0.1, HMW or/and polyglutamate 0.1, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 6.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1, collagen 0.01, collagen peptide 8.0、Vc 0.01、Ve 0.01、Vb50.01st, nicotinic acid 0.01, niacinamide 5.0, DPN 2.0, DPN I 0.01, sulfuric acid are soft Ossein 0.01, taurine 0.01, liquaemin 5.0, ubiquinone100.01st, trehalose 0.01, sodium alginate 0.01；Xanthans 9.0；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 0.001, Radix Glycyrrhizae Acid or/and its esters 4.0, urea 0.01, allantoin 0.01, lactate 5.0, citric acid 0.01, malic acid 0.01, tartaric acid 0.01 and salicylic acid or/and its esters 0.001, acetylsalicylic acid 25.0, Arginine Acetylsalicylate 0.002, lysine acetyl Salicylic acid 0.002, calcium acetylsalicylate urea 40.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.0001, PEG 20000 0.0001st, lactic acid 5.0, glycerine 0.0001, ethanol 5.0 and water 90.0；
Preparation method：Comprise the steps of：
（1）Formula as described in this patent and formula ratio weigh each component of skin care and removing acne and eliminating mark composition respectively, standby With；
（2）Formula as described in this patent and formula ratio weigh each component of this removing acne and eliminating mark skin conditioner solvent for use respectively, often Standby after temperature or low temperature mixing；
（3）Each component of the skin care composition of formula ratio is added solvent, normal temperature or the low temperature of part formulation amount Mix, obtain mixture A；
（4）Each component of the removing acne and eliminating mark composition of formula ratio is added solvent, normal temperature or the low temperature of part formulation amount Mix, obtain mixture B；
（5）Mixture B is slowly added in mixture A, then residual solvent is added thereto, normal temperature or low temperature are equal Even, obtain final product described removing acne and eliminating mark skin conditioner.
Embodiment 2：
Formula：
In described removing acne and eliminating mark skin conditioner, the quality proportioning of skin care composition, removing acne and eliminating mark composition and solvent three is： 8.00∶9.00∶83.00；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid of hyaluronate 5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 10.0, HMW or/and the polyglutamic acid of polyglutamate 4.0, middle-molecular-weihydroxyethyl Or/and the polyglutamic acid of polyglutamate 0.1, low-molecular-weight or/and polyglutamate 12.0, collagen 10.0, collagen egg White peptide 0.01, Vc 5.0, Ve 5.0, Vb58.0th, nicotinic acid 5.0, niacinamide 0.01, DPN 0.01, DPN I 2.0, sulfuric acid Chondroitin 5.0, taurine 5.0, liquaemin 0.01, ubiquinone105.0th, trehalose 9.0, sodium alginate 9.0；Xanthans 0.01；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 4.0, glycyrrhizic acid Or/and its esters 0.0 01, urea 15.0, allantoin 15.0, lactate 0.01, citric acid 5.0, malic acid 8.0, tartaric acid 8.0 and salicylic acid or/and its esters 35.0, acetylsalicylic acid 0.001, Arginine Acetylsalicylate 30.0, lysine acetyl water Poplar acid 40.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 40.0, polyethylene glycol 2000 15.0, lactic acid 0.01st, glycerine 0.0001, ethanol 10.0 and water 27.0；
Preparation method：With embodiment 1.
Embodiment 3：
Formula：
In described removing acne and eliminating mark skin conditioner, the quality proportioning of skin care composition, removing acne and eliminating mark composition and solvent three is： 15.00∶15.00∶70.00；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid of hyaluronate 1.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 1.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 1.0, HMW or/and polyglutamate 2.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 2.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 2.0, collagen 5.0, collagen peptide 4.0、Vc 3.0、Ve 2.50、Vb54.0th, nicotinic acid 2.0, niacinamide 3.0, DPN 1.0, DPN I 1.0, chondroitin sulfate 2.0th, taurine 3.0, liquaemin 2.0, ubiquinone103.0th, trehalose 5.0, sodium alginate 5.0, xanthans 4.0；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 2.0, glycyrrhizic acid Or/and its esters 0.1, urea 8.0, allantoin 7.0, lactate 3.0, citric acid 3.0, malic acid 4.0, tartaric acid 4.0 and water Poplar acid or/and its esters 18.0, acetylsalicylic acid 12.50, Arginine Acetylsalicylate 15.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 20.0, PEG400 8.0, lactic acid 3.0th, glycerine 10.0, ethanol 5.0 and water 55.0；
Preparation method：With embodiment 1.
Embodiment 4：
Formula：
In described removing acne and eliminating mark skin conditioner, the quality proportioning of skin care composition, removing acne and eliminating mark composition and solvent three is： 98.00∶1.90∶0.10；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid of hyaluronate 2.50, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 4.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 5.0, HMW or/and polyglutamate 2.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 3.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 6.0, collagen 2.0, collagen peptide 1.0、Vc 1.0、Ve 4.0、Vb51.0th, nicotinic acid 0.5, niacinamide 1.0, DPN 0.1, DPN I 0.2, chondroitin sulfate 2.50th, taurine 1.0, liquaemin 0.5, ubiquinone100.2nd, trehalose 3.0, sodium alginate 2.0, xanthans 2.0；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 1.0, glycyrrhizic acid Or/and its esters 0.5, urea 5.0, allantoin 1.0, lactate 0.1, citric acid 1.0, malic acid 1.0, tartaric acid 1.0 and water Poplar acid or/and its esters 10.0, acetylsalicylic acid 0.50；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.1, PEG 8000 0.1, lactic acid 0.1st, glycerine 0.1, ethanol 0.1 and water 99.40；
Preparation method：With embodiment 1.
Embodiment 5：
Formula：
In described removing acne and eliminating mark skin conditioner, the quality proportioning of skin care composition, removing acne and eliminating mark composition and solvent three is： 3.00∶5.00∶92.00；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid of hyaluronate 2.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 3.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 2.0, HMW or/and polyglutamate 2.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 4.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 3.0, collagen 3.0, collagen peptide 3.0、Vc 2.0、Ve 1.0、Vb52.0th, nicotinic acid 1.0, niacinamide 2.0, DPN 0.5, DPN I 0.5, chondroitin sulfate 3.0th, taurine 4.0, liquaemin 1.0, ubiquinone100.5th, trehalose 6.0, sodium alginate 6.0, xanthans 6.0；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 0.5, glycyrrhizic acid Or/and its esters 1.0, urea 2.0, allantoin 2.0, lactate 2.0, citric acid 2.0, malic acid 2.0, tartaric acid 2.0 and water Poplar acid or/and its esters 4.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.1, Macrogol 4000 5, lactic acid 5, sweet Oil 3, ethanol 15 and water 71.8；
Preparation method：With embodiment 1.
Embodiment 6：
Formula：
In described removing acne and eliminating mark skin conditioner, the quality proportioning of skin care composition, removing acne and eliminating mark composition and solvent three is： 0.50∶99.00∶0.50；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid of hyaluronate 2.50, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 4.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 5.0, HMW or/and polyglutamate 2.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 3.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 6.0, collagen 5.0, collagen peptide 4.0、Vc 2.5、Ve 2.5、Vb54.0th, nicotinic acid 2.5, niacinamide 2.5, DPN 1.0, DPN I 1.0, chondroitin sulfate 2.5th, taurine 2.5, liquaemin 2.5, ubiquinone102.5th, trehalose 4.5, sodium alginate 4.5, xanthans 4.5；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 0.1, glycyrrhizic acid Or/and its esters 1.5, urea 10.0, allantoin 4.0, lactate 3.0, citric acid 4.0, malic acid 4.0, tartaric acid 4.0 and water Poplar acid 20.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.01, PEG20000 0.05, breast Acid 0.3, glycerine 0.01, ethanol 50.0 and water 49.1；
Preparation method：With embodiment 1.
Embodiment 7：
Formula：
In described removing acne and eliminating mark skin conditioner, the quality proportioning of skin care composition, removing acne and eliminating mark composition and solvent three is： 6.00∶6.00∶88.00；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid of hyaluronate 4.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 6.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 8.0, HMW or/and polyglutamate 0.5, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 0.6, the polyglutamic acid of low-molecular-weight or/and polyglutamate 1.2, collagen 8.0, collagen peptide 6.0、Vc 4.0、Ve 3.0、Vb54.0th, nicotinic acid 2.0, niacinamide 4.0, DPN 0.8, DPN I 0.6, chondroitin sulfate 4.0th, taurine 4.0, liquaemin 4.0, ubiquinone104.0th, trehalose 8.0, sodium alginate 8.0, xanthans 6.0；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 3.0, glycyrrhizic acid Or/and its esters 2.5, urea 12.0, allantoin 8.0, lactate 4.0, citric acid 0.5, malic acid 1.5, tartaric acid 1.5 and water Poplar acid sodium；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 1.0, Macrogol 6000 1.0, lactic acid 1.0th, glycerine 1.0, ethanol 2.0 and water 92.0；
Preparation method：With embodiment 1.
The invention is not restricted to case study on implementation described above.

Claims (10)

1. a kind of removing acne and eliminating mark skin care multifunctional preparation it is characterised in that：This removing acne and eliminating mark skin conditioner is to be combined by skin care Thing, removing acne and eliminating mark composition and solvent are constituted, and wherein, described skin care composition includes high, normal, basic three kinds of different molecular weights The hyaluronic acid of size or/and hyaluronate, the polyglutamic acid of high, normal, basic three kinds of different molecular weight sizes or/and polyglutamic acid Salt, glutamic acid or/and glutamate, collagen, collagen peptide, Vc, Ve, Vb5, nicotinic acid, niacinamide, DPN, coenzyme II, chondroitin sulfate, taurine, liquaemin, ubiquinone10, trehalose, sodium alginate, xanthans；Described removing acne and eliminating mark combination Thing include sorbic acid and its esters, glycyrrhizic acid or/and its esters, urea, allantoin, lactic acid, lactate, malic acid, tartaric acid, Citric acid and salicylic acid or/and salt, acetylsalicylic acid, smart ammonia acetylsalicylic acid, lysine acetylsalicylate, calcium acetylsalicylate Arbitrary or a combination thereof of urea；Described solvent contains grape wine, lactic acid, polyethylene glycol, glycerine, second alcohol and water；
The quality proportioning of described skin care composition, removing acne and eliminating mark composition and solvent three is：0.1～98.00: 0.2～ 99.00: 0.1～99.70；Wherein, described skin care composition is by following mass percent（%）Raw material composition：High The hyaluronic acid of molecular weight or/and hyaluronate 0.1-5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1- 8.0th, the hyaluronic acid of low-molecular-weight or/and hyaluronate 0.1-10.0, the polyglutamic acid of HMW or/and polyglutamic acid Salt 0.1-4.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-6.0, the polyglutamic acid of low-molecular-weight or/and poly- Glutamate 0.1-12.0, collagen 0.01-10.0, collagen peptide 0.01-8.0, Vc 0.01-5.0, Ve 0.01- 5.0、Vb50.01-8.0, nicotinic acid 0.01-5.0, niacinamide 0.01-5.0, DPN 0.01-2.0, DPN I 0.01-2.0, Chondroitin sulfate 0.01-5.0, taurine 0.01-5.0, liquaemin 0.01-5.0, ubiquinone100.01-5.0, trehalose 0.01- 9.0th, sodium alginate 0.01-9.0, xanthans 0.01-9.0；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its esters 0.001- 4.0th, glycyrrhizic acid or/and its esters 0.001-4.0, urea 0.01-15.0, allantoin 0.01-15.0, lactate 0.01-5.0, Citric acid 0.01-5.0, malic acid 0.01-8.0, tartaric acid 0.01-8.0 and salicylic acid or/and its esters 0.001-35.0, second Acyl salicylic acid 0.001-25.0, Arginine Acetylsalicylate 0.002-30.0, lysine acetylsalicylate 0.002-40.0, A Si Arbitrary or a combination thereof in woods calcium urea 0.002-40.0；
Solvent of the present invention is by following mass percent（%）Raw material constitute：Grape wine 0.0001-40.0, polyethylene glycol 0.0001-15.0, lactic acid 0.01-5.0, glycerine 0.0001-10.0, ethanol 0.0001-50.0 and water 0.01-99.9；
Above-mentioned skin care composition, removing acne and eliminating mark composition and solvent are carried out science assemble and optimize, then using certain Technology method is made into the removing acne and eliminating mark skin conditioner formulation of Energy and comfort.
2. removing acne and eliminating mark skin conditioner according to claim 1 it is characterised in that：This removing acne and eliminating mark skin conditioner is skin care Composition, removing acne and eliminating mark composition and solvent carry out science and assemble and optimize, then using certain technology method preparation Become, the more high quality proportioning of described skin care composition, removing acne and eliminating mark composition and solvent three is：0.2～98.00: 0.3 ～99.00: 0.1～99.50；Wherein, described skin care composition presses following mass percent（%）Raw material composition：High The hyaluronic acid of molecular weight or/and hyaluronate 0.1-3.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1- 6.0th, the hyaluronic acid of low-molecular-weight or/and hyaluronate 0.1-8.0, the polyglutamic acid of HMW or/and polyglutamic acid Salt 0.1-3.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-5.0, the polyglutamic acid of low-molecular-weight or/and poly- Glutamate 0.1-6.0, collagen 0.1-8.0, collagen peptide 0.1-6.0, Vc 0.1-4.0, Ve 0.1-4.0, Vb5 0.1-6.0, nicotinic acid 0.05-3.0, niacinamide 0.05-3.0, DPN 0.05-1.0, DPN I 0.05-1.0, chondroitin sulfate 0.1-3.0, taurine 0.1-2.0, liquaemin 0.1-2.0, ubiquinone100.1-3.0, trehalose 0.01-9.0, sodium alginate 0.01-9.0, xanthans 0.1-5.0；
Described removing acne and eliminating mark composition includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 0. 01-2.0, Glycyrrhizic acid or/and its esters 0. 01-3.0, urea 0. 1-10.0, allantoin 0. 1-8.0, lactate 0.1-3.0, citric acid 0.1-3.0, malic acid 0.1-5.0, tartaric acid 0.1-5.0 and salicylic acid or/and its esters 0.01-20.0, acetylsalicylic acid 0.01-19.0, Arginine Acetylsalicylate 0.02-25.0, lysine acetylsalicylate 0.02-30.0, calcium acetylsalicylate urea Arbitrary or a combination thereof in 0.02-30.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.01-25.0, polyethylene glycol 0.01- 10.0th, lactic acid 0.1-3.0, glycerine 0.01-5.0, ethanol 0.01-30.0 and water 0.1-98.5.
3. removing acne and eliminating mark skin conditioner according to claim 1 it is characterised in that：Height in described removing acne and eliminating mark skin conditioner In the hyaluronic acid of low three kinds of different molecular weight sizes or/and hyaluronate refer to polymer hyaluronic acid or hyaluronate Molecular weight be more than 1,800,000 dalton, the molecular weight of middle molecular weight hyaluronic acid or hyaluronate is between 1,000,000-1 Between 800 000 dalton, the molecular weight of low molecular weight hyaluronic acid or hyaluronate is less than 600,000 dalton.
4. removing acne and eliminating mark skin conditioner according to claim 1 it is characterised in that：Described high, normal, basic three kinds of different molecular weights are big Little polyglutamic acid or/and polyglutamate refer to that polyphosphazene polymer glutamic acid or the molecular weight of polyglutamate are more than 1,000, 000 dalton, the molecular weight of middle molecule polyglutamic acid or polyglutamate between 600,000-1,000,000 dalton, The molecular weight of low molecular weight polycaprolactone glutamic acid or polyglutamate is less than 100,000 dalton.
5. the removing acne and eliminating mark skin conditioner according to claim 1 and 2 it is characterised in that：Grape wine in described solvent includes Red wine and white wine, the polyethylene glycol in solvent refers to that the molecular weight of more than food-grade is in 400-20000 dalton Any one or a combination thereof, lactic acid in solvent, grape-kernel oil, glycerine and ethanol is more than food-grade, and water is counter-infiltration level Above pure water or its distilled water.
6. Energy and comfort according to claim 1 removing acne and eliminating mark skin conditioner formulation it is characterised in that：Described Energy and comfort Removing acne and eliminating mark skin conditioner formulation mean aqua, vina, tincture, suspension, emulsion, creme, paste, gel, coagulant liquid, oil Agent, film, spray or patch.
7. a kind of preparation method of removing acne and eliminating mark skin conditioner according to claim 1 is it is characterised in that comprise the steps of：
（1）Formula as described in this patent and formula ratio weigh each component of skin care and removing acne and eliminating mark composition respectively, standby With；
（2）Formula as described in this patent and formula ratio weigh each component of this removing acne and eliminating mark skin conditioner solvent for use respectively, often Standby after temperature or low temperature mixing；
（3）Each component of the skin care composition of formula ratio is added solvent, normal temperature or the low temperature of part formulation amount Mix, obtain mixture A；
（4）Each component of the removing acne and eliminating mark composition of formula ratio is added solvent, normal temperature or the low temperature of part formulation amount Mix, obtain mixture B；
（5）Mixture B is slowly added in mixture A, then residual solvent is added thereto, normal temperature or low temperature are equal Even, obtain final product described removing acne and eliminating mark skin conditioner.
8. removing acne and eliminating mark skin conditioner according to claim 7 preparation method it is characterised in that：Described step（2）（3） （4）（5）In normal temperature or cryogenic conditions be preferably less than 42 DEG C, again more preferably less than 21 DEG C but be more than 10 DEG C.
9. removing acne and eliminating mark skin conditioner according to claim 7 preparation method it is characterised in that：Described step（2）（3） （4）（5）In the operating condition that stirs and evenly mixs be preferably two-dimentional mix and blend in medical stainless steel blender, more preferably exist Three-dimensional hybrid stirring in glass reactor or 316L stainless steel blender, further preferably for emulsifying side under vacuum Formula is realized.
10. Energy and comfort according to claim 1 removing acne and eliminating mark skin conditioner formulation it is characterised in that：Described convenience is relaxed Suitable removing acne and eliminating mark skin conditioner formulation includes liquid formulation and solid formulation, preferably half fluidised form preparation, more preferably aqueous solidifying Jelly, in practical application, can as needed and use Energy and comfort, with described removing acne and eliminating mark skin conditioner remove molten Composition outside agent is base-material, then mixes removing acne and eliminating mark skin conditioner acceptable carrier of the present invention or auxiliary material, is made using corresponding Agent technology make the convenient aqua being suitable for, vina, tincture, suspension, emulsion, creme, paste, gel, coagulant liquid, finish, Film, spray or patch.
CN201611027865.2A 2016-11-22 2016-11-22 Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof Pending CN106389139A (en)

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CN108403621A (en) * 2018-05-07 2018-08-17 广州度普生物科技有限公司 A kind of antibacterial blemish clearing gel of multiple target point and preparation method thereof
CN109820791A (en) * 2019-01-17 2019-05-31 东晟源研究院(广州)有限公司 A kind of moisture retention water and preparation method thereof convenient for absorption
CN110721115A (en) * 2019-12-10 2020-01-24 朱怀杰 Biological beauty skin cream for preventing and treating whelk and preparation method thereof
CN113908097A (en) * 2021-12-06 2022-01-11 华熙生物科技股份有限公司 Acne-removing composition and application thereof

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CN102973425A (en) * 2011-09-05 2013-03-20 张弘 Whitening anti-aging nanoscale skin-care agent
CN104840385A (en) * 2015-04-11 2015-08-19 广东医学院 A group of coenzyme Q10 skin protection creams with effects of skin moisturizing, wrinkle preventing and aging resistance
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CN107519081A (en) * 2017-08-25 2017-12-29 杭州惠博士健康产业有限公司 A kind of composition and preparation method that effect is repaired with anti-acne
CN108403621A (en) * 2018-05-07 2018-08-17 广州度普生物科技有限公司 A kind of antibacterial blemish clearing gel of multiple target point and preparation method thereof
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CN113908097A (en) * 2021-12-06 2022-01-11 华熙生物科技股份有限公司 Acne-removing composition and application thereof

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