CN106290476B - Keep structure and the detector including keeping structure - Google Patents
Keep structure and the detector including keeping structure Download PDFInfo
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- CN106290476B CN106290476B CN201610658321.XA CN201610658321A CN106290476B CN 106290476 B CN106290476 B CN 106290476B CN 201610658321 A CN201610658321 A CN 201610658321A CN 106290476 B CN106290476 B CN 106290476B
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- retainer
- plate
- orifice plate
- probe
- holding part
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
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Abstract
It is a kind of for keeping the holding structure of pattern detection orifice plate, orifice plate is with electrode and accommodates sample, and keeping structure includes retainer and pressure conversion plate.Retainer includes retainer main body, has the holding part for receiving orifice plate；With at least one probe module, it is set to the bottom of holding part.Probe module includes multiple contact probes, and one end includes being electrically connected to retainer control circuit perpendicular to the spring contact and the other end of the bottom translation of holding part；At least one switch probe, one end include perpendicular to the bottom translation of holding part elastic press section and the other end be electrically connected to retainer control circuit；And electrical insulating board, contact probe and switch probe are threaded through on electrical insulating board.When orifice plate is received in holding part, the spring contact of the bottom abutment contact probe of orifice plate and the elastic press section of switch probe, spring contact is electrically connected to the electrode on the bottom for being set to orifice plate, and orifice plate is between pressure conversion plate and the bottom of the holding part.
Description
Technical field
The present invention relates to a kind of for keeping the holding structure of pattern detection orifice plate, and is related to a kind of including the holding
The detector of structure.
Background technique
In pattern detection field, especially in the detection field of liquid biopsy, usually using the hole for having multiple holes
Plate holds biological sample, and the electrode and hole bottom electrically conducting of orifice plate, thus the low current signal of biological sample can lead to
Cross the signal detection processing unit that electrode is output to outside orifice plate.In addition, being led because the concentration of captured target molecules is very low
Cause current signal that can be detected also very faint, usually Naan or pico-ampere magnitude.And in current existing detection device,
It can only generally realize and detect a milliampere magnitude.Thus, it is desirable to which a kind of holding structure, can repeat to place orifice plate and prevent orifice plate
It overturns, the current signal of electrode is output to signal detection processing unit, guarantee the load of electric signal and detect the biography of signal
Defeated stability, and reduce interference of the external electromagnetic to the current signal exported to the greatest extent, while realizing the sealing of detection device,
Prevent external moisture, dust and liquid from penetrating into inside equipment.
Summary of the invention
The present invention realizes above-mentioned purpose for keeping the holding structure of pattern detection orifice plate by proposing a kind of, described
Orifice plate is with electrode and accommodates sample.The holding structure includes retainer and pressure conversion plate.Retainer includes: retainer master
Body has the holding part for receiving the orifice plate；With at least one probe module, it is set to the bottom of the holding part.
The probe module includes: multiple contact probes, and one end of the contact probe includes perpendicular to the holding part
Bottom translation spring contact and the other end be electrically connected to retainer control circuit；At least one switch probe, the switch
One end of probe include perpendicular to the bottom translation of the holding part elastic press section and the other end be electrically connected to retainer control
Circuit processed；And electrical insulating board, the contact probe and the switch probe are threaded through on the electrical insulating board.When the orifice plate quilt
When receiving in the holding part, the spring contact of contact probe described in the bottom abutment of the orifice plate and the switch probe
Elastic press section, the spring contact is electrically connected to the electrode being set on the bottom of the orifice plate, and the orifice plate is located at institute
It states between pressure conversion plate and the bottom of the holding part.
Preferably, the pressure conversion plate is rotatably mounted around the one axis of symmetry.
Preferably, the retainer includes the retainer flip lid rotated around first axle relative to the retainer main body,
The pressure conversion plate is mounted on retainer flip lid, and pressure conversion plate rotation around the axis of symmetry be parallel to
The first axle.
Preferably, the retainer flip lid has flip lid hollow open, and the pressure conversion plate is received in the flip lid
In hollow open.
Preferably, the pressure conversion plate and retainer flip lid are provided with mutually matched rotation retention device.
Preferably, the pressure conversion plate has the positioning device for making the orifice plate positioning.
It preferably, is a part of detector, the pressure conversion plate is mounted on the chassis lid of detector.
Preferably, the chassis lid of detector rotates around second axis relative to box body and has receiving portion, the pressure
Power change-over panel is received in the receiving portion, and pressure conversion plate rotation around the axis of symmetry be parallel to described the
Two axis.
Preferably, the pressure conversion plate and the chassis lid are provided with mutually matched rotation retention device.
Preferably, the pressure conversion plate is the form of hollow, rectangular frame.
Preferably, the holding part includes fence, and the fence is protruded outward from the bottom of the holding part around institute
State orifice plate, and the holding part is electrical isolation and integral with the electrical insulating board.
Preferably, the retainer main body includes closed circular wall, the closed circular wall from the retainer main body to
Outer protrusion, and it is located at the periphery of the fence, the closed circular wall carries sealing element.
Preferably, the retainer further includes the support plate for supporting the retainer main body, and the support plate includes notch,
The contact probe and the switch probe and the support plate contactlessly pass through the notch.
Preferably, the support plate is located at below the retainer main body, and have towards the retainer main body the
Side and second side backwards to the retainer main body, the support plate is fixed to the retainer main body, carries the guarantor
The control panel of holder control circuit is fixed to the support plate in second side of the support plate and is spaced apart with the support plate.
Preferably, the support plate is made of metal material.
Preferably, the holding part includes the box body for accommodating the orifice plate, and the box body is arranged in the electrical insulating board
On bottom.
Preferably, the retainer main body is made of metal material.
Preferably, the holding part further includes orifice plate close to space.
Preferably, the probe module includes multiple switch probe.
Preferably, the switch probe is normal open switch.
Preferably, the holding part bottom is provided with the error prevention device for the orifice plate.
The invention further relates to a kind of detectors comprising above-mentioned holding structure and cabinet.
Holding structure according to the present invention can ensure that orifice plate is correctly kept and its bottom electrode can be visited with contacting
Needle contacts securely, to avoid open circuit, enables circuit to be continuous and stablely the electrode power supply on orifice plate, and electric current
Signal can transmit without interruption.Detector according to the present invention can effectively shield from the interior space electromagnetic wave and
The electromagnetic interference for the current signal that the electromagnetic radiation of equipment internal electronic device exports electrode, at the same prevent external moisture,
Dust and liquid penetrate into inside equipment.
In the absence of conflict, the feature in the same embodiment of the invention and different embodiment can be combined with each other.
Detailed description of the invention
By following attached drawing, those skilled in the art will present invention may be better understood, and advantages of the present invention
It will more clearly be embodied.Attached drawing described herein is only for illustrating the purpose of embodiment, rather than all feasible embodiment party
Formula, and be not intended to limit the scope of the invention.
Fig. 1 is the perspective view according to one embodiment of the holding structure of present aspect；
Fig. 2A is the sectional view along its longitudinal direction of contact probe, when Fig. 2 B is that contact probe is arranged in electrical insulating board
Schematic diagram；
Fig. 3 schematically shows schematic diagram when orifice plate 9 is pressed against contact probe and switchs probe；
Fig. 4 schematically shows the working principles of pressure conversion plate；
Fig. 5 is the top view that structure is kept shown in Fig. 1, and wherein the retainer of retainer renovates closure；
Fig. 6 is the top view that structure is kept shown in Fig. 1, and wherein the retainer of retainer, which is renovated, opens；
Fig. 7 is the perspective view observed from below that structure is kept shown in Fig. 1；
Fig. 8 is the perspective view of the second embodiment according to the present invention for keeping structure；
Fig. 9 is the top view shown in fig. 8 for keeping structure；
Figure 10 is the perspective view shown in fig. 8 for keeping structure, shows the bottom of retainer main body；
Figure 11 is the side view cutaway drawing shown in fig. 8 for keeping structure；
Figure 12 is the perspective view of the first embodiment of detector according to the present invention；
Figure 13 is the perspective view of detector shown in Figure 12, wherein the outer cover of cabinet is opened and structure is kept to be removed；
Figure 14 is that the partially schematic of mode is sealingly engaged between the cabinet of detector shown in Figure 12 and retainer main body
Figure；
Figure 15 A is the solid viewed from above of the retainer main body of the 3rd embodiment according to the present invention for keeping structure
Figure；
Figure 15 B is the schematic diagram of the example of fence；
Figure 16 is the perspective view observed from below that the retainer main body of structure is kept shown in Figure 15；
Figure 17 A and 17B are the schematic diagrames of the example of pressure conversion plate；
Figure 18 is the schematic diagram of the second embodiment of detector according to the present invention；
Figure 19 is the side view cutaway drawing of detector shown in Figure 18；
Figure 20 and 21 be respectively include different embodiment according to the subject invention holding structure detector schematic diagram.
Specific embodiment
Preferred embodiment in accordance with the present invention is described in detail below with reference to attached drawing.By attached drawing and accordingly
Explanatory note, skilled person will further understand that the features of the present invention and advantage.
Fig. 1 shows the holding structure 1 of first embodiment according to the present invention, is used to keep pattern detection orifice plate (Fig. 1
In be not shown), the orifice plate with electrode and accommodate sample.The holding structure 1 may include retainer 10.The retainer 10 can wrap
Retainer main body 100 is included, there can be the holding part 110 that can receive orifice plate.Retainer 10 can further include at least one probe
Module 200 is set to the bottom 111 of holding part 110.In this first embodiment, retainer 10 may include two probe modules
200 (Fig. 5).
Probe module 200 may include multiple contact probes 210 and electrical insulating board 230.Fig. 2A and 2B are please referred to, is shown
The structure of one contact probe 210.As shown in Figure 2 A, contact probe 210 may include contact probe main body 212, such as with
Tubular form, the contact probe main body 212 can be arranged on electrical insulating board 230 (Fig. 2 B), for example, being worn by interference fit
If.Contact probe main body 212 can at one end have opening 214, and inside limit stroke space 213, the trip space 213 with
214 connection of opening.Contact probe main body 212 is being obstructed with the 214 opposite other ends of opening, and includes being electrically connected at the end
It is connected to the terminal 215 of retainer circuit.Contact probe 210 can further include spring contact 211, and spring contact 211 can be perpendicular to
The bottom 111 of holding part 110 translates.As shown in Figure 2 A, spring contact 211 may include top section 2111, shoulder 2112 and
Compresses lower section 2113.Shoulder 2112 and compresses lower section 2113 are located in the stroke space 213, which can be in stroke
The peripheral portion for limiting the opening 214 is engaged in space, top section 2111 extends opening 214, lower part from shoulder 2112
Section 2113 is from shoulder towards stroke space internal stretch.Settable elastic device between compresses lower section 2113 and stroke space bottom
Part 216, for example, helical spring.When top section 2111 is by contact pressure F 1 straight down, spring contact 211 can gram
It takes the restoring force of spring 216 and translates downwards, shoulder 2112 is detached from the engagement with the peripheral portion in hole 214.When pressure F discharges
When, spring contact 211 can reset under the action of the restoring force of spring 216.Contact probe 210 is whole can be by metal material system
At.The quantity of contact probe 210 and its position correspond to quantity and its position of the electrode 91 of 9 bottom of orifice plate.
Probe module 200 can further include at least one switch probe 220, as shown in Figure 3.Switch probe 220 is also arranged in
On electrical insulating board 230, such as worn by interference fit, and one end may include perpendicular to holding part 110 bottom 111 it is flat
The elastic press section 221 of shifting, and the other end has the terminal 225 for being electrically connected to retainer control circuit.Switch the interior of probe 220
Portion's structure can be similar to the internal structure of contact probe 210.Fig. 5 also schematically shows orifice plate 9, and is set to orifice plate 9
Bottom on electrode 91.When orifice plate 9 is received in holding part 110, the bullet of the bottom abutment contact probe 210 of orifice plate 9
Property contact 211 and switch probe 220 elastic press section 221, meanwhile, spring contact 211 is electrically connected to the electricity on 9 bottom of orifice plate
Pole 91.
Contact probe 210 can have it is preferable to use stroke, be somebody's turn to do it is preferable to use 60% to 70% that stroke is, for example, total kilometres,
Particularly, at 2/3rds positions of the total kilometres of contact probe 210, contact probe has optimum performance state, at this point, its
Elastic force, the electrical contact situation of inner body, service life are in comprehensive optimal state.In order to make contact probe 210 always exist
It in stroke it is preferable to use working, and according to preferred embodiment, whether switch probe 220 can detect contact probe 210 in it
It is preferable to use in stroke.Specifically, (switch probe is greater than or is equal to when switch probe 220 is pressed next triggering stroke
The 60% of total kilometres) when, it can just trigger its open or closed state.The connecting and disconnecting situation of detectable circuit, to know out
Whether pass probe is pressed down toward triggering stroke, it can thus be appreciated that whether contact probe is depressed into, it is preferable to use strokes.
Probe module 200 may include multiple switch probe 220, such as two, three, four, even more.Preferably,
Retainer 10 switchs probe 220 there are four being arranged in total, such as is respectively arranged at the corner portion of holding part 110, so that working as hole
Plate 9 is placed in holding part and held stationary when pressure conversion plate is non-depressed.It is in disconnected under normal conditions, all switching probe 220
Open state all switchs probe 220 and connects when pressing plate 9 is pressed down against contact probe 210 and switch probe 220 by power F2,
Retainer control circuit is just switched on, and is thus prevented circuit accidental switch and is carried out invalid detection.
Fig. 1 is returned to, retainer main body 100 can be made of metal material.In addition, the holding part 110 of retainer main body 100 can
Box body 112 including accommodating orifice plate, periphery matches with the peripheral shape of orifice plate 9 so that orifice plate 9 be easy to place and taking-up and
Limit its level sliding.The box body 112 can be made of metal material, and electrical insulating board 230 may be provided at the bottom of the box body 112
On.At this point, jagged (not shown), contact probe 210 and switch probe 220 and metal case is arranged in the bottom of box body 112
112 contactlessly pass through the notch.
Further, retainer 10 may include the retainer rotated around first axle X1-X1 relative to retainer main body 100
Flip lid 300, for example, it is made of metal material.Retainer flip lid 300 can be attached to retainer main body by articulation piece 301
100, thus rotatable relative.Retainer flip lid 300 can be covered on 110 top of holding part.Articulation piece 301 for example can be damping
Type loose-leaf allows retainer to renovate 300 and rests on its any rotation position without free-falling, avoids causing to anticipate to orifice plate 9
Outer impact.
Keeping structure 1 can further include pressure conversion plate 20, such as also be made of metal material.Example shown in Fig. 1
In, the pressure conversion plate 20 is mountable on retainer flip lid 300.When orifice plate 9 is received in holding part 110, orifice plate 9
Between pressure conversion plate 20 and the bottom 111 of holding part 110.Pressure conversion plate 20 can be rotatable around its axis of symmetry A-A
Ground is mounted on retainer flip lid 300, which can be parallel to retainer flip lid 300 relative to retainer main body 100
Rotation around first axle X1-X1.As shown in Figure 1, retainer flip lid 300 can have flip lid hollow open 302, pressure conversion
Plate 20 can be received in the flip lid hollow open.Pressure conversion plate 20 can be by such as relative to the rotation of retainer flip lid 300
Under type realizes (Figure 17 A), is provided in two edges perpendicular to axis of symmetry A-A of pressure conversion plate 20 along symmetry axis
The outwardly extending axis 21 of line A-A, two axis 21 are mounted on (not shown) on the corresponding axle bed of retainer flip lid 300.Such as Figure 17 A institute
Show, pressure conversion plate 20 there can be hollow window 23, allow to carry out automatic sample.
Fig. 4 shows the schematic diagram of the working principle for the pressure conversion plate 20 being mounted on retainer flip lid 300.Such as Fig. 4
It is shown, and Fig. 1 is combined, when retainer flip lid 300 is rotated around first axle X1-X1 towards orifice plate 9, pressure conversion plate 20 can be first
The edge 92 for first contacting the close first axle X1-X1 of orifice plate 9, at this point, since pressure conversion plate 20 can be turned over relative to retainer
Lid 200 rotates, and cannot generate the power for moving down orifice plate 9, when retainer flip lid 200 continues rotation, pressure conversion plate
20 rotate around axis of symmetry A-A along the direction that arrow D is indicated against the edge of orifice plate 9 92, until pressure conversion plate 20 is bonded hole
The upper surface of plate 9.When retainer flip lid 200 continues rotation, pressure conversion plate 20 can apply uniform and substantially vertical to orifice plate 9
Power in the upper surface of orifice plate 9 (as shown in power F2 in Fig. 3), that is, the direction of the power is roughly parallel to the elasticity of contact probe 210
The direction that the elastic press section 211 of contact 211 and switch probe 220 translates.
In the example shown in Fig. 1-3, holding part 110 can receive the rectangle orifice plate 9 in 96 holes, and pressure conversion plate 20 can have
The form of flattened rectangular frame, when retainer 300 closure of flip lid, the periphery of pressure conversion plate 20 can be pressed against the surrounding of orifice plate 9.
Pressure conversion plate 20 and retainer flip lid 300 can further include mutually matched rotation retention device.For example, in pressure
Being parallel on the edge of axis of symmetry A-A for change-over panel 20 may be provided with bar 22 (as shown in Figure 17 A), and bar 22 can be from described
The outside projection in edge.Correspondingly, it may be provided with (the figure of recess portion 303 at the position corresponding with bar 22 of retainer flip lid 300
6), bar 22 is engageable in the recess portion 303.Preferably, the pressure conversion plate 20 of rectangle can be parallel to axis of symmetry A-A
Two edges on be both provided with bar 22.Rotation retention device with fit form can have other shapes apart from the above
Formula, and may also be arranged on the other positions of retainer flip lid 300 and pressure conversion plate 20, as long as realizing that pressure conversion plate 20 is opposite
In the relative rotation of the limited angle of retainer flip lid 300.The setting of rotation retention device can be turned over to avoid in retainer
Lid 300 be rotated down during may as rotating freely for pressure conversion plate 20 and caused by the accidental impact of orifice plate 9
And damage.
In addition, in order to be correctly received orifice plate 9 in holding part 110 and be held in place, it can on pressure conversion plate 20
It is additionally provided with positioning device, for example, positioning column 24 (Fig. 6), the positioning column 24 is also error prevention device.It is rectangular opening in orifice plate 9
In the case where plate, positioning column 24 be may be provided at the top corner portion of pressure conversion plate 20, such as in two adjacent top corner portions
Place, as shown in Figure 6.Positioning column 24 can be approximately perpendicular to pressure conversion plate 20 along the direction extension towards 9 upper surface of orifice plate, that is,
In retainer 300 closure of flip lid, positioning column 23 extends towards holding part 110.It correspondingly, can in the corresponding position of orifice plate 9
It is provided with cut-out, when retainer 300 closure of flip lid, positioning column 24 can be received in the corresponding cut-out of orifice plate 9.
Cut-out can for example have the shapes such as rectangle, triangle.In the detection, the sample to be detected in each hole of orifice plate 9 and inspection
Survey purpose be it is different, therefore, orifice plate 9 must be received in holding part 110 with preset bearing, when 9 orientation of orifice plate mistake
It mistakes, retainer flip lid 300 cannot be closed.It therefore ensures that being properly positioned for orifice plate 9 is installed with safety, avoids generating any connection
Mistake and invalid detection resulting from.The quantity of positioning column 24 is necessarily two, can be other quantity, such as one
Or three, and the position of positioning column 24 also need not be as shown in Figure 6, as long as can ensure that orifice plate 9 is properly positioned.
Fig. 5 is the top view that structure 1 is kept shown in Fig. 1, wherein 300 closure of retainer flip lid of retainer 10.Figure
6 be the top view that structure 1 is kept shown in Fig. 1, and wherein the retainer flip lid 300 of retainer 10 is opened.As shown, keeping
Device flip lid 300 can further include handle 303 and can set relative to the lock 304 of the handle 303 rotation, handle 303 and lock 304
It sets at the free edge opposite with articulation piece 301 of retainer flip lid 300.Correspondingly, retainer main body 100 may be provided with
The lock fixing piece 101 of 304 cooperation of lock, retainer is renovated 300 and retainer main body in retainer 300 closure of flip lid
100 lockings, to orifice plate 9 be compressed wherein, so that the spring contact 211 of the electrode 91 of orifice plate 9 and contact probe 210 is firm
Contact.Preferably, it may be provided with sensor (invisible to operator) in lock fixing piece 101, which is connected to
Controller and can to controller send signal.When latching 304 with latching the correct Ground fastener of fixing piece 101 and locking, sensor
The signal of 300 closure of instruction retainer flip lid in place is sent to controller, at this point, controller could start detection process.
As shown in Fig. 1,5 and 6, retainer main body 100 can be additionally provided with groove 104, be located at retainer main body 100
In upper surface.Groove 104 can be the annular groove around holding part 110, inside may be provided with sealing element, for example, sealant
Circle 105.When retainer main body 100 is mounted in the cabinet of detector, the table top of cabinet passes through the sealing element and retainer master
The sealing installation of body 100.
Fig. 7 shows the perspective view of retainer main body 1 observed from below.Retainer main body 100 may include retainer master
Pillar body 102, for retainer 10 to be supported in the cabinet of detector.Retainer main body 100 can further include being set to holding
Shielding box 120 on the bottom of device main body 100.The shielding box 120 can be made of metal material, and have parallelepiped shape,
The bottom of retainer main body 100 is opened wide and be fixed at the open side in one side of shielding box 120, such as by opening wide
Side surrounding projects outwardly edge 121 to fix.The control panel of carrying holder control circuit, for example, printed circuit board,
It may be provided inside the shielding box 120.Contact probe 210 and switch probe 220 may pass through the welding hole on control panel, and pass through
It welds and is fixed on control panel, be achieved in their being electrically connected with retainer control circuit.
It may be provided at least one hole on other sides of shielding box 120, for example, four holes as shown in Figure 7
122, the lower terminal 225 of a switch probe is pierced by from each hole 122.
Fig. 8-11 shows the schematic diagram of the holding structure 1 ' of second embodiment according to the present invention.The holding structure 1 ' is used
In the holding another orifice plate 9 ' different from the orifice plate 9 in first embodiment, such as the orifice plate 9 ' with 16 holes.The holding knot
Structure ' 1 may include retainer 10 '.The retainer 10 ' may include retainer main body 100 ', have the accommodating that can receive orifice plate
Portion 110 '.Retainer 10 ' can further include at least one probe module 200, be set to the bottom 111 ' of holding part 110 '.Probe mould
The construction of block 200 can be similar to the construction of the probe module 200 according to a first embodiment of the present invention, but contact probe 210
Quantity and position are arranged for orifice plate 9 '.
In this embodiment, retainer main body 100 ' can be made of metal material.In addition, the accommodating of retainer main body 100 '
Portion 110 ' may include the box body 112 ' for accommodating orifice plate, such as be made of metal material.Electrical insulating board 230 may be provided at the box body
On 112 ' bottom, bottom setting is jagged, and contact probe 210 and switch probe 220 and metal case 112 ' are contactlessly
Pass through the notch.
Holding part 110 is described below with reference to Fig. 1,8 and 9.Holding part 110,110 ' may include orifice plate close to space 113,
113 ' (being indicated by dotted line frame), allow the finger of operator to be inserted, easily to place and take out orifice plate 9 and 9 '.?
In the example of Fig. 1, the two sides of long side of 96 orifice plates 9 and placed in the middle are arranged in close to space 113 in orifice plate；In the example of Fig. 8 and 9,
Orifice plate is arranged close to space 113 ' in the two sides of the long side of 16 orifice plates 9 ' and placed in the middle.But the long side of 16 orifice plates 9 ' is approximately perpendicular to 96
The long side of orifice plate 9.The present invention provides the accommodating that one kind can share different orifice plates (such as 96 orifice plates 9 ' of orifice plate 9 and 16) as a result,
Portion 110,110 '.When shared holding part 110,110 ' receives orifice plate (such as 96 orifice plates 9) of the first kind, the close sky of orifice plate
Between 113 ' occupied by the orifice plate of the first kind；When shared holding part 110,110 ' receives orifice plate (such as 16 holes of Second Type
Plate 9 ') when, orifice plate is occupied close to space 113 by the orifice plate of Second Type, particularly, is used for the probe mould of Second Type orifice plate 9 '
Block 200 may be provided at the orifice plate for first kind orifice plate 9 close in space 13 (Fig. 9).Shared holding part 110,110 ' is permitted
Perhaps first produce the component with same shape, the different orifice plates being directed to further according to it and carry out different settings, such as probe
Thus material and cost are saved in the position of module, the position etc. of bottom notch.
Also as shown in FIG. 8 and 9, it is identical with the first embodiment, pressure conversion plate 20 ' may be provided at retainer flip lid 300 '
In hollow open, but its shape is different from the pressure conversion plate 20 in first embodiment, and is adapted for the orifice plate of Second Type, example
Such as 16 orifice plates 9 '.
The control panel 130 of carrying holder control circuit is also shown in Figure 11, is located at 230 lower section of electrical insulating board, and
It is internal in shielding box 120 '.It is solderable thereon to switch probe 220.
Figure 12 shows the perspective view of the first embodiment of detector 8 according to the present invention.Figure 13 is shown in Figure 12
The structure of the cabinet 80 of detector 8, wherein keep structure 1 or 1 ' it has been removed.Detector 8 is used for the noninvasive gene of liquid biopsy
Accurate detection, for example, the epidermis for detecting cancer patient in clinical or pathology laboratory by detection human body fluid
Growth factor receptor mutations.Detector 8 may include cabinet 80 and be contained in the cabinet 80 according to the present invention first implement
The holding structure 1 of example.The cabinet 80 can equally accommodate holding structure 1 ' according to a second embodiment of the present invention.Specifically, cabinet
80 may include chassis lid 810 and in the open cabinet 820 in top side, and chassis lid 810 can be for example rotatably attached by articulation piece 801
It is connected to box body 820, and box body 820 can be closed hermetically to form closed inner space.The example shown in Figure 12
In, box body 820 can have the shape of parallelepiped, but the present invention is not limited thereto, and box body 820 can be according to actual needs
And there are other suitable shapes.Cabinet 80 can further include table top 830, can fix and be covered in the top of the box body 820
Side keeps structure 1,1 ' and related electronic device for accommodating, such as main to be encircled into an internal capacity with box body 820
Plate etc..Table top 830 can be flat metal plate, such as with rectangular shape, and including table top opening 831 (for example, being located at table top
830 center).When keeping structure 1 and 1 ' to be accommodated in box body 820, upper part part is revealed from table top opening 831
Out.The periphery of table top 830 is sealably fixed to the side of cabinet 22.Chassis lid 810 and box body 820 can also be by metals
Material is made, to shield electromagnetic interference.
May be provided with observation window 811 on chassis lid 810, to observe orifice plate 9 or 9 at any time ' state.But on chassis lid 810
It can also be not provided with observation window 811, but whole single metal component, to enhance effectiveness.In box body 820
Appropriate position can be additionally provided with power switch 821 and indicator light 822, such as be used to indicate different operating situation, instruction orifice plate
Placement status etc..As shown in Figure 13, the bottom of box body 820 may be provided with the multiple retainer pillars 821 extended inward
(one is only shown in figure), for for supporting and being maintained in box body 820 by retainer 10.
Referring now to Figure 14, that schematically shows keep structure 1 or 1 ' how to be accommodated in box body 820 and
It is formed and is sealingly engaged with table top 830.When retainer 1,1 ' is placed in box body 820, the retainer of retainer 10,10 '
Groove 104 in main body 100,100 ' passes through the sealing element 105 being disposed therein and engages with table top 830.Sealing element 105, such as
Sealing rubber ring may be provided on the inside of the vertical wall of table top 830 between a side wall of groove 104, be achieved in retainer 10,
10 ' with the sealing engagement of cabinet 80, effectively prevent interference of the external environment to the component that cabinet inside is arranged in.
Figure 15 A and 16 shows the schematic diagram of the retainer 10 " of the 3rd embodiment 1 " of storage configuration according to the present invention.
Retainer 10 " may include retainer main body 100 ", have the holding part 110 " that can receive orifice plate.Retainer 10 " can be wrapped also
At least one probe module 200 " is included, the bottom 111 " of holding part 110 " is set to.With the of storage configuration 1 according to the present invention
Probe module 200 in one embodiment is similar, and probe module 200 " may include multiple contact probes 210, at least one switch spy
Needle 220 and electrical insulating board 230.Contact probe 210 and the structure for switching probe 220 can be identical as what is described before, here not
It repeats again.
As shown in fig. 15, which renovates without retainer.Keeping structure 1 " can further include pressure conversion plate
20 ", such as be made of metal material, which is mounted on the chassis lid 810A of the cabinet 80A of detector 8A
(Figure 18 and Figure 19).This will be explained below.
Holding part 110 " may include fence 140, and the fence 140 can be protruded outward from the bottom 111 " of holding part 110 ",
To surround orifice plate 9 and limit its level sliding.Figure 15 B shows two possible forms of fence 140.But the form of fence 140
It is not limited in example shown in figure.
Holding part 110 " is electrical isolation, and is integral with electrical insulating board 230.The retainer main body 100 " is whole can be with
It is electrical isolation, such as is made of plastic material.Retainer main body 100 " can further include closed circular wall 150, from retainer master
Body 100 " protrudes outward and is located at the periphery of fence 140.The closed circular wall 150 can carry sealing element 151, such as sealant
Circle.As shown in figure 15 a, retainer main body 100 " can further include mistake proofing column 141, be arranged in 110 " bottom of holding part, and
It is protruded outward from holding part 110 ".In order to make orifice plate 9 or 9 ' be received in holding part 110 " with predetermined direction, in orifice plate 9 or
The corresponding position of 9 ' bottoms can be provided with the recess portion for receiving mistake proofing column 141, and rest part then general planar.Work as hole
When plate is placed with the direction different from predetermined direction, the recess portion of bottom cannot engage mistake proofing column 141, thus cannot be to moving down
It is dynamic, at this point, it is inclined state that orifice plate, which can be observed, in operator.
Figure 16 shows the retainer 10 " observed from below.Retainer 10 " can further include support retainer main body 100 "
Support plate 400, support plate 400 can be located at the lower section of retainer main body 100 ", such as be fixed to the bottom of retainer main body 100 ",
And be made of metal material, the structural strength of retainer is thus further strengthened, while providing electromagnetic shielding.Support plate 400 can
It is arranged jagged 401, contact probe 210 and switch probe 220 can contactlessly pass through notch 401 with support plate 400.Support plate
400 can have the first side (not shown) towards retainer main body 100 " and second side 402 backwards to the retainer main body,
The control panel 130 " (Figure 19) of carrying holder control circuit second side 402 of support plate 400 be fixed to support plate 400 and with
Support plate 400 is spaced apart.
The pressure conversion plate 20 " of holding structure 1 " is described below with reference to Figure 18 and 19.Figure 18 and 19 is shown according to this
The second embodiment 8A of the detector of invention.As shown, detector 8A may include cabinet 80A, cabinet 80A may include chassis lid
810A and box body 820A.When orifice plate is received in holding part 110 ", orifice plate is located at pressure conversion plate 20 " and holding part
Between 110 " bottom 111 ".Pressure conversion plate 20 " can be rotatably installed in chassis lid 810A around its axis of symmetry A-A
On, such as pass through its axis 21 " (Figure 17 B).The axis of symmetry A-A can be parallel to chassis lid 810A and rotate relative to box body 820A
Around second axis X2-X2.Particularly, chassis lid 810A can have receiving portion 811A, and pressure conversion plate 20 " is received in
In receiving portion 811A.The construction of pressure conversion plate 20 " can have a form of rectangular frame as seen in this fig. 17b, but can be with
Not flat rectangular frame has thicker thickness, compared with the pressure conversion plate 20 in first embodiment to adapt to
Chassis lid 80A with bigger thickness.The working principle of pressure conversion plate 20 " is identical as pressure conversion plate 20, here no longer
It repeats.When chassis lid 810A closure when, the periphery of pressure conversion plate 20 " can be pressed against orifice plate 9 or 9 ' surrounding.
Pressure conversion plate 20 " and chassis lid 810A can further include mutually matched rotation retention device.For example, turning in pressure
Changing being parallel on the edge of axis of symmetry A-A for plate 20 " may be provided with bar 22 ", and bar 22 " can be from the edge to evagination
It stretches.Correspondingly, chassis lid 810A includes lever receiving portion 812A (Figure 19).Rotation retention device with fit form can have
There are other forms in addition to those described above, and may also be arranged on the other positions of chassis lid 810A and pressure conversion plate 20 ", only
Realize relative rotation of the pressure conversion plate 20 " relative to the limited angle of chassis lid 810A.
It may be provided with power switch 821A and indicator light 822A on box body 820A.
Detector 8A can further include panel 830A, be, for example, metal decking.As shown in figure 19, box body 820A may include
First shielding case 823A, secondary shielding shell 824A and third shielding case 825A, they are metal shielding.First shielding case
823A is arranged around retainer 10 ", by retainer main body 100 ", the control of probe module 200 ", carrying holder control circuit
Plate 130 etc. is surrounded in it.Secondary shielding shell 824A and third shielding case 825A surrounds the first shielding case 823A and detector
The master board 81A master board 81A of 8A is located at except the first shielding case 823A.As a result, by metal decking 830A, retainer
Support plate 400, the first shielding case 823A, secondary shielding shell 824A and third shielding case 825A may make up box-like shield, effectively
Ground is electromagnetically shielded the local current path on control panel and probe.
When chassis lid 810A closure, what the closed circular wall 150 that inside is pressed against in retainer main body 100 " was carried
Sealing element 151 realizes the sealing engagement between retainer and cabinet 80A.
Figure 20 shows one embodiment of detector 8A comprising can receive the holding knot of the orifice plate 9 ' in three 16 holes
Structure.Correspondingly, chassis lid 810A is mountable there are three pressure conversion plate 20 " '.
Figure 21 shows another embodiment of detector 8A comprising can receive the holding knot of the orifice plate 9 ' in 16 holes
Structure.Correspondingly, chassis lid 810A is mountable a pressure conversion plate 20 " '.
Although better model of the invention to execution has carried out detailed description, those skilled in the art can be obtained
Know within the scope of the appended claims be used to implement many alternative designs and embodiments of the invention.
Claims (22)
1. a kind of for keeping the holding structure of pattern detection orifice plate, the orifice plate is with electrode and accommodates sample, and feature exists
In the holding structure includes retainer and pressure conversion plate, and the retainer includes:
Retainer main body has the holding part for receiving the orifice plate；With
At least one probe module, is set to the bottom of the holding part, and the probe module includes:
Multiple contact probes, one end of the contact probe include perpendicular to the bottom translation of the holding part spring contact and
The other end is electrically connected to retainer control circuit；
At least one switch probe, it is described switch probe one end include perpendicular to the holding part bottom translation elasticity by
Splenium and the other end are electrically connected to retainer control circuit；With
Electrical insulating board, the contact probe and the switch probe are threaded through on the electrical insulating board；
Wherein, when the orifice plate is received in the holding part, the bullet of contact probe described in the bottom abutment of the orifice plate
Property contact and the switch probe elastic press section, the spring contact is electrically connected on the bottom for being set to the orifice plate
Electrode, and wherein, the contact probe has it is preferable to use stroke, and the switch probe is used for whether detecting the contact probe
In it is preferable to use in stroke, and the orifice plate is between the pressure conversion plate and the bottom of the holding part.
2. keeping structure as described in claim 1, which is characterized in that the pressure conversion plate is rotatable around the one axis of symmetry
Ground installation.
3. keeping structure as claimed in claim 2, which is characterized in that the retainer includes around first axle relative to described
The retainer flip lid of retainer main body rotation, the pressure conversion plate is mounted on the retainer flip lid, and the pressure turns
Change plate rotation around the axis of symmetry be parallel to the first axle.
4. keeping structure as claimed in claim 3, which is characterized in that the retainer flip lid has flip lid hollow open, institute
Pressure conversion plate is stated to be received in the flip lid hollow open.
5. keeping structure as claimed in claim 3, which is characterized in that the pressure conversion plate and retainer flip lid setting
There is mutually matched rotation retention device.
6. keeping structure as claimed in claim 3, which is characterized in that the pressure conversion plate has and makes orifice plate positioning
Positioning device.
7. keeping structure as claimed in claim 2, which is characterized in that it is a part of detector, the pressure conversion plate
It is mounted on the chassis lid of detector.
8. keeping structure as claimed in claim 7, which is characterized in that the chassis lid of detector is relative to box body around the second axis
Line rotates and has receiving portion, and the pressure conversion plate is received in the receiving portion, and the pressure conversion plate revolves
Turn around the axis of symmetry be parallel to the second axis.
9. keeping structure as claimed in claim 7, which is characterized in that the pressure conversion plate and the chassis lid are provided with phase
The rotation retention device mutually cooperated.
10. keeping structure as claimed in any one of claims 1-9 wherein, which is characterized in that the pressure conversion plate is hollow square
The form of shape frame.
11. keeping structure as described in claim 1, which is characterized in that the holding part includes fence, and the fence is from described
The bottom of holding part is protruded outward to surround the orifice plate, and the holding part is electrically insulated and with the electrical insulating board at one
Body.
12. keeping structure as claimed in claim 11, which is characterized in that the retainer main body includes closed circular wall, institute
It states closed circular wall to protrude outward from the retainer main body, and is located at the periphery of the fence, the closed circular wall carrying
There is sealing element.
13. keeping structure as claimed in claim 11, which is characterized in that the retainer further includes supporting the retainer master
The support plate of body, the support plate include notch, and the contact probe and the switch probe and the support plate are contactlessly
Across the notch.
14. keeping structure as claimed in claim 13, which is characterized in that the support plate is located under the retainer main body
Side, and there is the first side towards the retainer main body and second side backwards to the retainer main body, the support plate
It is fixed to the retainer main body, the control panel for carrying the retainer control circuit is fixed in second side of the support plate
The support plate is simultaneously spaced apart with the support plate.
15. holding structure according to claim 13 or 14, which is characterized in that the support plate is made of metal material.
16. keeping structure as described in claim 1, which is characterized in that the holding part includes the box body for accommodating the orifice plate,
The electrical insulating board is arranged on the bottom of the box body.
17. keeping structure as claimed in claim 16, which is characterized in that the retainer main body is made of metal material.
18. keeping structure as claimed in claim 16, which is characterized in that the holding part further includes orifice plate close to space.
19. keeping structure as described in claim 1, which is characterized in that the probe module includes multiple switch probe.
20. keeping structure as described in claim 1, which is characterized in that the switch probe is normal open switch.
21. keeping structure as claimed in claim 6, which is characterized in that the holding part bottom is provided with for the orifice plate
Error prevention device.
22. a kind of detector, which is characterized in that it includes holding structure and the machine as described in any one of claim 1-21
Case.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610658321.XA CN106290476B (en) | 2016-08-11 | 2016-08-11 | Keep structure and the detector including keeping structure |
| PCT/CN2017/105434 WO2018028722A2 (en) | 2016-08-11 | 2017-10-10 | Holding structure and detector comprising holding structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610658321.XA CN106290476B (en) | 2016-08-11 | 2016-08-11 | Keep structure and the detector including keeping structure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106290476A CN106290476A (en) | 2017-01-04 |
| CN106290476B true CN106290476B (en) | 2019-06-07 |
Family
ID=57669551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610658321.XA Expired - Fee Related CN106290476B (en) | 2016-08-11 | 2016-08-11 | Keep structure and the detector including keeping structure |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106290476B (en) |
| WO (1) | WO2018028722A2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106290476B (en) * | 2016-08-11 | 2019-06-07 | 广州易活生物科技有限公司 | Keep structure and the detector including keeping structure |
| CN110118803A (en) * | 2018-02-07 | 2019-08-13 | 北京易活生物科技有限公司 | Sample testing apparatus |
| CN110806309B (en) * | 2018-08-03 | 2022-03-08 | 施耐德电器工业公司 | Testing device for contactor |
| CN112992599B (en) * | 2019-12-13 | 2023-02-17 | 天津平高智能电气有限公司 | Vacuum degree measuring device for vacuum arc extinguish chamber |
| CN112680322B (en) * | 2021-01-29 | 2022-09-16 | 青岛汉唐生物科技有限公司 | Supplementary application of sample and tectorial membrane device |
| CN114785427B (en) * | 2022-03-09 | 2024-01-30 | 昆山浩兴电子科技有限公司 | Portable WIFI signal detection device |
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|---|---|---|---|---|
| CN1811619A (en) * | 2005-01-26 | 2006-08-02 | 精工爱普生株式会社 | Timepiece movement holding structure and timepiece |
| CN201096804Y (en) * | 2007-07-10 | 2008-08-06 | 翔宏兴业有限公司 | Chip testing device |
| CN201194023Y (en) * | 2008-04-07 | 2009-02-11 | 比亚迪股份有限公司 | Integrated circuit testing apparatus |
| CN203965474U (en) * | 2014-06-13 | 2014-11-26 | 浙江长兴电子厂有限公司 | The test jack of tape insulation frame ageing |
| CN104956189A (en) * | 2013-01-25 | 2015-09-30 | 流体处理有限责任公司 | Rotatable orifice plate for direct flow measurement |
| CN105190291A (en) * | 2012-12-18 | 2015-12-23 | 安盛生科股份有限公司 | Method and apparatus for analyte measurement |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6057259A (en) * | 1983-09-09 | 1985-04-03 | Konishiroku Photo Ind Co Ltd | Device for biochemical analysis |
| CN204945191U (en) * | 2015-08-10 | 2016-01-06 | 苏州赛腾精密电子股份有限公司 | Flip-shell probe module |
| CN106290476B (en) * | 2016-08-11 | 2019-06-07 | 广州易活生物科技有限公司 | Keep structure and the detector including keeping structure |
-
2016
- 2016-08-11 CN CN201610658321.XA patent/CN106290476B/en not_active Expired - Fee Related
-
2017
- 2017-10-10 WO PCT/CN2017/105434 patent/WO2018028722A2/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1811619A (en) * | 2005-01-26 | 2006-08-02 | 精工爱普生株式会社 | Timepiece movement holding structure and timepiece |
| CN201096804Y (en) * | 2007-07-10 | 2008-08-06 | 翔宏兴业有限公司 | Chip testing device |
| CN201194023Y (en) * | 2008-04-07 | 2009-02-11 | 比亚迪股份有限公司 | Integrated circuit testing apparatus |
| CN105190291A (en) * | 2012-12-18 | 2015-12-23 | 安盛生科股份有限公司 | Method and apparatus for analyte measurement |
| CN104956189A (en) * | 2013-01-25 | 2015-09-30 | 流体处理有限责任公司 | Rotatable orifice plate for direct flow measurement |
| CN203965474U (en) * | 2014-06-13 | 2014-11-26 | 浙江长兴电子厂有限公司 | The test jack of tape insulation frame ageing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106290476A (en) | 2017-01-04 |
| WO2018028722A3 (en) | 2018-04-12 |
| WO2018028722A2 (en) | 2018-02-15 |
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