CN106075546A - A kind of have the soft tissue binding agent promoting wound healing effect - Google Patents

A kind of have the soft tissue binding agent promoting wound healing effect Download PDF

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Publication number
CN106075546A
CN106075546A CN201610399485.5A CN201610399485A CN106075546A CN 106075546 A CN106075546 A CN 106075546A CN 201610399485 A CN201610399485 A CN 201610399485A CN 106075546 A CN106075546 A CN 106075546A
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China
Prior art keywords
parts
soft tissue
wound healing
binding agent
healing effect
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Withdrawn
Application number
CN201610399485.5A
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Chinese (zh)
Inventor
董芬芳
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Huzhou Guoxin Materials Co Ltd
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Huzhou Guoxin Materials Co Ltd
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Priority to CN201610399485.5A priority Critical patent/CN106075546A/en
Publication of CN106075546A publication Critical patent/CN106075546A/en
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/102—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses a kind of soft tissue binding agent having and promoting wound healing effect, it comprises following parts by weight of component: polyvinyl alcohol 80 85 parts, Rofe scale collagen 4 16 parts, chitosan 10 14 parts, carbomer 35 parts, linoleic acid 59 parts, polyvinylpyrrolidone 29 parts, Radix Angelicae Sinensis powder 10 15 parts, succinic acid 5 11 parts, 25 parts of glutamic acid, stannous octoate 35 parts, sodium carboxymethyl cellulose 5 10 parts, Fibrin Glue 10 15 parts, sodium alginate 11 15 parts.A kind of soft tissue binding agent with promotion wound healing effect of the present invention has higher adhesion strength and comprcssive strength, bio-tissue is stimulated little, without any harmful reagent, also there is the effect promoting wound healing, it is suitable in surgical operation, is especially suitable for the bonding of soft tissue.

Description

A kind of have the soft tissue binding agent promoting wound healing effect
Technical field
The invention belongs to biomedical materials field, be specifically related to a kind of soft tissue use having and promoting wound healing effect Binding agent.
Background technology
Biomaterial is for tissue and the diagnosis of organ, the class High-tech Material repairing or promoting its function, I.e. being used for replacing, repairing living tissue natural or artificial material, its drugs with function is irreplaceable.Biomaterial can perform, promote Or replace certain function lost because of disease, damage etc., and rejected region can not be recovered.Since the later stage nineties, the world is raw Thing material science and technology develop rapidly, even if under the overall situation that current global economy is low, biomaterial still remains Annual 13% rapid growth, has fully demonstrated its powerful vitality and vast potential for future development.Modern medicine forward regeneration and Rebuild impaired tissue and organ, recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment and develop. The conventional materials such as traditional abiotic medical metal, macromolecule, bioceramic can not meet the requirement of medical development, biological Medical material scientific and engineering is faced with new opportunities and challenges.In future, the market share of bio-medical material may well Medicine will be caught up with.Therefore, strengthen clinical application research and the popularization and application of bio-medical material, give priority to China's bio-medical The research of material, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice, country is current at biology Fundamentals of Material Science research aspect has been achieved for important breakthrough progress, walks in world's rank of advanced units, but industrialization level is still Waiting to improve, industry size is little, development relatively lags behind, and is not met by being actually needed of Medicare health care.At national policy, warp Under the support energetically of Ji, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen the ability of autonomous innovation, further Solve to rely on the situation of import, add large outlet dynamics, it is achieved spanning development simultaneously, expand Chinese biological material product in the world Power of influence.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial includes that metal material is (such as alkali Metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyapatite etc.) and organic material three major types.Organic material In mainly polymeric set laminate material, macromolecular material is generally divided into synthesis macromolecular material (polyurethane, poly-by material properties Ester, polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber etc.), natural macromolecular material (such as collagen, fibroin, cellulose, chitosan etc.)；According to the purposes of material, these materials can be divided into again biologically inert (bioinert), biological activity (bioactive) or biodegradation (biodegradable) material, in high molecular polymer, root Can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again Bioabsorbable and biological nonabsorable Property.Blood compatible polymer and blood then it is divided into according to the state that affects on blood constituent, performance after material and contacting blood Incompatibility.To the affinity of body cell and report situations according to material, biocompatibility and bio-incompatibility can be divided into Polymer etc..
Adhesive of medical just belongs to the one in biodegradation material, adhesive of medical be mainly used in various traumatic wounds, The various operation of the surgery such as cosmetic surgery, family planning, it has quick-binding, promotes that wound healing etc. is made biological tissue of human body With, can partly replace wound suture.The use of adhesive of medical is with a long history, has highly important effect in clinic, can divide For soft tissue binding agent, dental binding agent, bone cement and skin binding agent etc..Wherein, soft tissue binding agent is with life Fabric texture is bonding object, and human body overwhelming majority tissue, organ can apply adhering technique replacement part over the course for the treatment of Sew up, ligation operation, it is not necessary to anesthesia.Soft tissue adhesives purpose is to promote the normal healing of tissue itself, but existing soft Tissue adhesive comes with some shortcomings, such as bonding strength deficiency, function singleness etc..Accordingly, it would be desirable to it is strong to develop a kind of high bonding Spend and there is the soft tissue binding agent promoting wound healing effect.
Summary of the invention
It is an object of the invention to provide a kind of soft tissue binding agent having and promoting wound healing effect.
To achieve these goals, the invention provides a kind of soft tissue bonding having and promoting wound healing effect Agent, comprises following parts by weight of component: polyvinyl alcohol 80-85 part, Rofe scale collagen 4-16 part, chitosan 10-14 part, carbomer 3-5 part, linoleic acid 5-9 part, polyvinylpyrrolidone 2-9 part, Radix Angelicae Sinensis powder 10-15 part, succinic acid 5-11 part, glutamic acid 2-5 part, Stannous octoate 3-5 part, sodium carboxymethyl cellulose 5-10 part, Fibrin Glue 10-15 part, sodium alginate 11-15 part.
It also comprises glycerol 5-15 part.
It also comprises ethylene glycol 2-8 part.
It also comprises zinc oxide 3-5 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in container, after the most ultrasonic 1-6h, It is then heated to 40-100 DEG C, stirs 1-3h, then disinfection.
Beneficial effect: a kind of soft tissue binding agent with promotion wound healing effect of the present invention has higher gluing Knotting strength and comprcssive strength, stimulate little to bio-tissue, without any harmful reagent, also has the merit promoting wound healing Effect, is suitable in surgical operation, is especially suitable for the bonding of soft tissue.
Detailed description of the invention
Embodiment 1
The soft tissue binding agent with promotion wound healing effect of the present embodiment, comprises following parts by weight of component: poly- Vinyl alcohol 80 parts, Rofe scale collagen 4 parts, chitosan 10 parts, carbomer 3 parts, linoleic acid 5 parts, polyvinylpyrrolidone 2 parts, Radix Angelicae Sinensis powder 10 parts, succinic acid 5 parts, 2 parts of glutamic acid, stannous octoate 3 parts, sodium carboxymethyl cellulose 5 parts, Fibrin Glue 10 parts, Sodium alginate 11 parts.
Embodiment 2
The soft tissue binding agent with promotion wound healing effect of the present embodiment, comprises following parts by weight of component: poly- Vinyl alcohol 85 parts, Rofe scale collagen 16 parts, chitosan 14 parts, carbomer 5 parts, linoleic acid 9 parts, polyvinylpyrrolidone 9 parts, Radix Angelicae Sinensis powder 15 parts, succinic acid 11 parts, 5 parts of glutamic acid, stannous octoate 5 parts, sodium carboxymethyl cellulose 10 parts, Fibrin Glue 15 Part, sodium alginate 15 parts, glycerol 15 parts.
Embodiment 3
The soft tissue binding agent with promotion wound healing effect of the present embodiment, comprises following parts by weight of component: poly- Vinyl alcohol 80 parts, Rofe scale collagen 4 parts, chitosan 10 parts, carbomer 3 parts, linoleic acid 5 parts, polyvinylpyrrolidone 2 parts, Radix Angelicae Sinensis powder 10 parts, succinic acid 5 parts, 2 parts of glutamic acid, stannous octoate 3 parts, sodium carboxymethyl cellulose 5 parts, Fibrin Glue 10 parts, Sodium alginate 11 parts, glycerol 5 parts, ethylene glycol 2 parts.
Embodiment 4
The soft tissue binding agent with promotion wound healing effect of the present embodiment, comprises following parts by weight of component: poly- Vinyl alcohol 85 parts, Rofe scale collagen 16 parts, chitosan 14 parts, carbomer 5 parts, linoleic acid 9 parts, polyvinylpyrrolidone 9 parts, Radix Angelicae Sinensis powder 15 parts, succinic acid 11 parts, 5 parts of glutamic acid, stannous octoate 5 parts, sodium carboxymethyl cellulose 10 parts, Fibrin Glue 15 Part, sodium alginate 15 parts, glycerol 15 parts, ethylene glycol 8 parts, zinc oxide 5 parts.
The above, be only presently preferred embodiments of the present invention, and the present invention not makees any pro forma restriction, though So the present invention is disclosed above with preferred embodiment, but is not limited to the present invention, any technology people being familiar with this specialty Member, in the range of without departing from technical solution of the present invention, when the technology contents of available the disclosure above makes a little change or modification For the Equivalent embodiments of equivalent variations, as long as being the content without departing from technical solution of the present invention, the technical spirit of the foundation present invention Any simple modification, equivalent variations and the modification being made above example, all still falls within the range of technical solution of the present invention.

Claims (4)

1. one kind has the soft tissue binding agent promoting wound healing effect, it is characterised in that comprise following parts by weight of component: Polyvinyl alcohol 80-85 part, Rofe scale collagen 4-16 part, chitosan 10-14 part, carbomer 3-5 part, linoleic acid 5-9 part, poly-second Alkene pyrrolidone 2-9 part, Radix Angelicae Sinensis powder 10-15 part, succinic acid 5-11 part, glutamic acid 2-5 part, stannous octoate 3-5 part, carboxymethyl fibre Dimension element sodium 5-10 part, Fibrin Glue 10-15 part, sodium alginate 11-15 part.
The most according to claim 1 have the soft tissue binding agent promoting wound healing effect, it is characterised in that: it is also Comprise glycerol 5-15 part.
The most according to claim 2 have the soft tissue binding agent promoting wound healing effect, it is characterised in that: it is also Comprise ethylene glycol 2-8 part.
The most according to claim 3 have the soft tissue binding agent promoting wound healing effect, it is characterised in that: it is also Comprise zinc oxide 3-5 part.
CN201610399485.5A 2016-06-06 2016-06-06 A kind of have the soft tissue binding agent promoting wound healing effect Withdrawn CN106075546A (en)

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CN201610399485.5A CN106075546A (en) 2016-06-06 2016-06-06 A kind of have the soft tissue binding agent promoting wound healing effect

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Application Number Priority Date Filing Date Title
CN201610399485.5A CN106075546A (en) 2016-06-06 2016-06-06 A kind of have the soft tissue binding agent promoting wound healing effect

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593053A (en) * 1984-12-07 1986-06-03 Medtronic, Inc. Hydrophilic pressure sensitive biomedical adhesive composition
CN1579560A (en) * 2003-07-31 2005-02-16 天津大学 Coblended contact glue of poly N-ethenyl pyrrolidone and polyvinyl alcohol and its use
CN101418196A (en) * 2007-10-24 2009-04-29 天津大学 Pressure sensitive viscous composite using rice flour as raw material and use thereof
CN102596275A (en) * 2009-09-04 2012-07-18 亚洲大学校产学协力团 In situ-forming hydrogel for tissue adhesives and biomedical use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593053A (en) * 1984-12-07 1986-06-03 Medtronic, Inc. Hydrophilic pressure sensitive biomedical adhesive composition
CN1579560A (en) * 2003-07-31 2005-02-16 天津大学 Coblended contact glue of poly N-ethenyl pyrrolidone and polyvinyl alcohol and its use
CN101418196A (en) * 2007-10-24 2009-04-29 天津大学 Pressure sensitive viscous composite using rice flour as raw material and use thereof
CN102596275A (en) * 2009-09-04 2012-07-18 亚洲大学校产学协力团 In situ-forming hydrogel for tissue adhesives and biomedical use thereof

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Application publication date: 20161109