CN105902290A - Titanium nickel-based shape memory alloy tissue closing clip - Google Patents

Titanium nickel-based shape memory alloy tissue closing clip Download PDF

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Publication number
CN105902290A
CN105902290A CN201610407973.6A CN201610407973A CN105902290A CN 105902290 A CN105902290 A CN 105902290A CN 201610407973 A CN201610407973 A CN 201610407973A CN 105902290 A CN105902290 A CN 105902290A
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titanium
guan
folder
outer arc
arc segments
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CN105902290B (en
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杨西群
杨潇
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Priority to PCT/CN2016/111526 priority Critical patent/WO2017107955A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • A61B17/083Clips, e.g. resilient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32Surgical cutting instruments
    • A61B17/3205Excision instruments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02Inorganic materials
    • A61L31/022Metals or alloys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00862Material properties elastic or resilient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00867Material properties shape memory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/16Materials with shape-memory or superelastic properties

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Surgical Instruments (AREA)
  • Prostheses (AREA)

Abstract

The invention relates to a titanium nickel-based shape memory alloy tissue closing clip. The closing clip is a closed strip made of a hyperelastic titanium nickel-based shape memory alloy material, and the closed strip is formed through end-to-end connection of at least three outer segmental arcs and the same number of inner segmental arcs in a stagger mode into a dish shape or bowl shape. The tissue closing clip is used for closing for treating tissue perforation, anal fistula endostoma and alimentary tract hemorrhage as well as excision of polypus tissue. The shape memory property and hyperelasticity of titanium nickel-based shape memory alloy are utilized, the closing clip is opened when temperature is lower than set temperature or under external force and is automatically closed when temperature is higher than set temperature or external force is withdrawn, and treatment is achieved through continuous automatic pressurization on focus. The closing clip is quite simple in structure, machining process is simple, operation process is simple, and no foreign matter is left in body finally.

Description

Titanium Ni-based marmem tissue closure presss from both sides
Technical field
The present invention relates to a kind of tissue closure folder, particularly relate to a kind of employing Ni-based shape memory alloy material of titanium The tissue closure folder made.The tissue closure folder of the present invention, for tissue perforation, anal fistula internal orifice, digestive tract Hemorrhage Guan Bi and the excision of polyp tissue.
Background technology
The tissue closer used clinically at present, is to use disposable digestive tract closer as auxiliary Help apparatus, as used stainless steel lag screws to be coincide by otch when doing anal fistula internal orifice Guan Bi, or use purse string suture side Anal fistula internal orifice is closed by method.This device is invasive surgery apparatus, and patient to suffer exquisite pain, And stainless steel lag screws by prolonged stay in human body, even cause operative failure.
Summary of the invention
It is an object of the present invention to provide a kind of titanium Ni-based marmem tissue closure folder, it makes use of titanium Ni-based The shape memory characteristic of memorial alloy and super-elasticity, less than design temperature or opening under external force, Automatically close after unloading higher than design temperature or external force, focus is carried out lasting Self-pressurizing agri to reach treatment Purpose.
The technical solution of the present invention is:
A kind of titanium Ni-based marmem tissue closure folder, is made up of the Ni-based shape memory alloy material of titanium, It is characterized in that, including the Guan Bi clip main body being made up of the band closed;The band of described Guan Bi is by interlocking At least three outer arc segments of arrangement and the interior segmental arc the roundest and the most smooth connection of head and the tail of equal number;Described Guan Bi folder is main Body is plane layout, disk like layout or bowl-shape layout.
For ensureing closure effect, above-mentioned Guan Bi folder also includes being arranged on each interior segmental arc top and pointing to Guan Bi folder The detent projection at center.
The quantity of the outer arc segments of above-mentioned Guan Bi folder can be 3,4,5,6 or 8.
For further enhancing closure effect, above-mentioned Guan Bi folder may also include identical with outer arc segments quantity and one a pair The parallel folder answered;Described parallel folder includes two clamps be arrangeding in parallel;The fixing end of said two clamp divides Other and outer arc segments two ends are connected, and its on-fixed end is positioned at this outer arc segments area defined.
For preventing unexpected in closing course coming off, the side that above-mentioned two clamp is relative is respectively arranged with engagement dress Put;Described geared assembly includes the tine locations of at least one pointed tooth of evagination and described pointed tooth and relative clamp Stagger, or include at least one pointed tooth of evagination and the groove of indent and described groove and relative clamp The quantity mating shapes of pointed tooth, or include at least one round and smooth projection and the round and smooth groove of indent of evagination And the round and smooth number of projection mating shapes of described round and smooth groove and relative clamp.
Place, the top diameter of a circle of above-mentioned all outer arc segments is 10-20mm, the top of all interior segmental arcs or top Detent projection place, portion diameter of a circle is 1-4mm;The coning angle of described Guan Bi clip main body is 120-180 °, institute The spacing stating two clamps is 0.5-2mm.
Place, the top diameter of a circle of above-mentioned all outer arc segments is 12-16mm, the top of all interior segmental arcs or top Detent projection place, portion diameter of a circle is 1-3mm;The coning angle of the band of described Guan Bi is 160 °.
The invention has the beneficial effects as follows:
1, the present invention closes folder for closing banding, by being staggered multiple outer arc segments and interior segmental arc joins end to end Forming, structure is the simplest.
2, the present invention closes folder titanium Ni-based marmem sheet material or tubing cuts into closing band, warp Memory processes and can use, and processing technique is simple.
3, in order to strengthen closure effect, the present invention closes folder and have employed level Four anti-drop device:
The first order is Guan Bi folder body, and it has hyperelastic titanium Ni-based shape note when using higher than memory temperature Recall alloy material to make, set the memory temperature of material less than body temperature, when Guan Bi folder enters in human body, material Material shows super-elasticity, to contract, persistently pressurizes tissue;
The second level is provided in each interior segmental arc top and points to the detent projection at Guan Bi folder center, and it can thrust Organization internal, prevents closing folder and comes off;
The third level is to arrange parallel folder, comprehensive grip tissue, improves closure effect;
The fourth stage is to arrange geared assembly on parallel folder, by the geared assembly being oppositely arranged on parallel folder, Can grip tissue further, can prevent the accident of Guan Bi folder from coming off to greatest extent.
4, operation process of the present invention is simple.Guan Bi folder, when tissue closure, is clipped in tissue and wears by the present invention In inn peripheral tissues, the detent projection in the interior segmental arc of Guan Bi folder or interior segmental arc is treated under body temperature effect Anastomosed tissue internal orifice peripheral tissues carries out Self-pressurizing agri, and tissue internal orifice peripheral tissues is formed without new wound, Keep good blood circulation while overcoming tissue tension, promote the Guan Bi of tissue perforation internal orifice, operation Effective.
5, present invention Guan Bi is clipped in the blood circulation that histozoic one end keeps good, has promoted tissue to wear While the healing of aperture, the other end clamped makes tissue closure folder automatically because of the tissue necrosis that tissue ischemia causes Come off, finally can accomplish internal not stay foreign body.
6, the present invention Guan Bi be clipped in particular cases tissue closure folder also can remove with instrument, it is possible to plant for a long time Enter internal.
7, the present invention excises and the dual-use function of engaging tissue in a organized way.
8, the present invention uses to cardioid closed mode, can realize comprehensive Guan Bi, than existing parallel Guan Bi The closure effect of pattern is good.
9, the present invention is atraumatic operating theater instruments.
Accompanying drawing explanation
Fig. 1 to Fig. 4 is the schematic diagram of the tissue closure folder including 3 outer arc segments;Wherein:
Fig. 1 is the front view before memory deformation;
Fig. 2 is the three-dimensional effect diagram before memory deformation, it can be seen that band is generally aligned in the same plane;
Fig. 3 be memory deformation after look up design sketch, it can be seen that interior segmental arc offsets to one side;
Fig. 4 is the three-dimensional effect diagram after memory deformation, it can be seen that interior segmental arc offsets to one side;
Fig. 5 to Fig. 8 be include 3 outer arc segments and interior segmental arc top tape detent projection tissue closure folder show It is intended to;Wherein:
Fig. 5 is the front view before memory deformation;
Fig. 6 is the three-dimensional effect diagram before memory deformation, it can be seen that band is generally aligned in the same plane;
Fig. 7 be memory deformation after look up design sketch, it can be seen that interior segmental arc offsets to one side;
Fig. 8 is the three-dimensional effect diagram after memory deformation, it can be seen that interior segmental arc offsets to one side;
Fig. 9 to Figure 12 is the schematic diagram of the tissue closure folder including 4 outer arc segments;Wherein:
Fig. 9 is the front view before memory deformation;
Figure 10 is the three-dimensional effect diagram before memory deformation, it can be seen that band is generally aligned in the same plane;
Figure 11 be memory deformation after look up design sketch, it can be seen that interior segmental arc offsets to one side;
Figure 12 is the three-dimensional effect diagram after memory deformation, it can be seen that interior segmental arc offsets to one side;
Figure 13 to Figure 16 is the tissue closure folder including 4 outer arc segments and interior segmental arc top tape detent projection Schematic diagram;Wherein:
Figure 13 is the front view before memory deformation;
Figure 14 is the three-dimensional effect diagram before memory deformation, it can be seen that band is generally aligned in the same plane;
Figure 15 be memory deformation after look up design sketch, it can be seen that interior segmental arc offsets to one side;
Figure 16 is the three-dimensional effect diagram after memory deformation, it can be seen that interior segmental arc offsets to one side;
Figure 17 to Figure 20 is the schematic diagram of the tissue closure folder including 5 outer arc segments;Wherein:
Figure 17 is the front view before memory deformation;
Figure 18 is the three-dimensional effect diagram before memory deformation, it can be seen that band is generally aligned in the same plane;
Figure 19 be memory deformation after look up design sketch, it can be seen that interior segmental arc offsets to one side;
Figure 20 is the three-dimensional effect diagram after memory deformation, it can be seen that interior segmental arc offsets to one side;
Figure 21 to Figure 24 is the tissue closure folder including 5 outer arc segments and interior segmental arc top tape detent projection Schematic diagram;Wherein:
Figure 21 is the front view before memory deformation;
Figure 22 is the three-dimensional effect diagram before memory deformation, it can be seen that band is generally aligned in the same plane;
Figure 23 be memory deformation after look up design sketch, it can be seen that interior segmental arc offsets to one side;
Figure 24 is the three-dimensional effect diagram after memory deformation, it can be seen that interior segmental arc offsets to one side;
Figure 25 to Figure 28 is the schematic diagram of the tissue closure folder including 6 outer arc segments;Wherein:
Figure 25 is the front view before memory deformation;
Figure 26 is the three-dimensional effect diagram before memory deformation, it can be seen that band is generally aligned in the same plane;
Figure 27 be memory deformation after look up design sketch, it can be seen that interior segmental arc offsets to one side;
Figure 28 is the three-dimensional effect diagram after memory deformation, it can be seen that interior segmental arc offsets to one side;
Figure 29 to Figure 32 is the tissue closure folder including 6 outer arc segments and interior segmental arc top tape detent projection Schematic diagram;Wherein:
Figure 29 is the front view before memory deformation;
Figure 30 is the three-dimensional effect diagram before memory deformation, it can be seen that band is generally aligned in the same plane;
Figure 31 be memory deformation after look up design sketch, it can be seen that interior segmental arc offsets to one side;
Figure 32 is the three-dimensional effect diagram after memory deformation, it can be seen that interior segmental arc offsets to one side;
Figure 33 to Figure 36 is the schematic diagram of the tissue closure folder including 8 outer arc segments;Wherein:
Figure 33 is the front view before memory deformation;
Figure 34 is the three-dimensional effect diagram before memory deformation, it can be seen that band is generally aligned in the same plane;
Figure 35 be memory deformation after look up design sketch, it can be seen that interior segmental arc offsets to one side;
Figure 36 is the three-dimensional effect diagram after memory deformation, it can be seen that interior segmental arc offsets to one side;
Figure 37 to Figure 40 is the tissue closure folder including 8 outer arc segments and interior segmental arc top tape detent projection Schematic diagram;Wherein:
Figure 37 is the front view before memory deformation;
Figure 38 is the three-dimensional effect diagram before memory deformation, it can be seen that band is generally aligned in the same plane;
Figure 39 be memory deformation after look up design sketch, it can be seen that interior segmental arc offsets to one side;
Figure 40 is the three-dimensional effect diagram after memory deformation, it can be seen that interior segmental arc offsets to one side;
Figure 41 is to include 4 outer arc segments, interior segmental arc top tape detent projection, band 4 parallel folders and parallel The schematic diagram of the tissue closure folder of detent projection it is provided with on folder;
Figure 42 is to include 4 outer arc segments, interior segmental arc top tape detent projection, band 4 parallel folders and parallel The schematic diagram of the tissue closure folder of detent projection and groove it is provided with on folder;
Figure 43 is to include 4 outer arc segments, interior segmental arc top tape detent projection, band 4 parallel folders and parallel The schematic diagram of the tissue perforation internal orifice Guan Bi folder of round and smooth projection and round and smooth groove it is provided with on folder;
Figure 44 is to include 3 outer arc segments, interior segmental arc top tape detent projection, band 3 parallel folders and parallel Be provided with on folder round and smooth projection and round and smooth groove tissue perforation internal orifice Guan Bi folder open mode schematic diagram;
Figure 45 is to include 3 outer arc segments, interior 3 segmental arc top tape detent projection, 3 parallel folders of band and put down The schematic diagram of the tissue perforation internal orifice Guan Bi folder of round and smooth projection and round and smooth groove it is provided with on row folder;
Figure 46 is the stereoeffect schematic diagram of tissue perforation internal orifice Guan Bi folder in Figure 45;
Reference: 91-outer arc segments, segmental arc in 92-, 93-detent projection, 94-clamp, 941-pointed tooth, 942-V shape groove, the round and smooth projection of 943-, the round and smooth groove of 944-.
Detailed description of the invention
Titanium of the present invention Ni-based marmem tissue closure presss from both sides, and including Guan Bi clip main body, Guan Bi clip main body is The band of the Guan Bi that the Ni-based shape memory alloy material of titanium is made, band is by staggered at least three outer arc The interior segmental arc head and the tail of section and equal number are connected in sequence plane layout, disk like layout or bowl-shape layout; The coning angle scope of the band of the Guan Bi of this disk like layout or bowl-shape layout is 120-180 °, most preferably 160°.Guan Bi band is added by having hyperelastic titanium Ni-based shape memory alloy material during higher than memory temperature Work is the memory character needed clinically.When External Force Acting or less than memory temperature time can change its shape, outward After power unloading or again higher than refresh memory shape during memory temperature.The optimal number of outer arc segments be 3 or 4, during specific demand, it would however also be possible to employ 5,6 or 8.
Band is the Ni-based shape memory alloy material of titanium, for having super-elasticity under its memory temperature, and External Force Acting Under can change its shape, external force recovers its shape memory after disappearing.
For reaching optimal surgical effect, under the conditions of memory temperature, set shape memory, the top of all interior segmental arcs Place, portion diameter of a circle is 1-4mm, and place, the top diameter of a circle of all outer arc segments is 10-20mm;Low Can change, with outer arc under the conditions of memory temperature and by place, the top diameter of a circle of segmental arc in external force Equivalently-sized.When meeting or exceeding memory temperature and after external force unloading, the top of all interior segmental arcs is in band The heart is drawn close rear place diameter of a circle and is reverted to 1-4mm.
In order to prevent, Guan Bi folder is unexpected to come off, and can reach more preferable closure effect simultaneously, also can be in each interior segmental arc Top arranges detent projection, and detent projection is all towards Guan Bi folder center.
For further enhancing closure effect, Guan Bi folder may also include the parallel folder consistent with outer arc segments quantity;Often Individual parallel folder includes two clamps be arrangeding in parallel;The fixing end of two clamps is solid with the two ends of outer arc segments respectively Even, its on-fixed end is positioned at this outer arc segments area defined.
For preventing in closing course unexpected coming off, also engagement can be respectively arranged with at the side that two clamps are relative Device.Geared assembly can be there to be various structures form, and three kinds of main structures are:
1, geared assembly includes at least one pointed tooth of evagination, and pointed tooth is wrong with the tine locations of relative clamp Open;In Figure 41, each clamp includes that two pointed tooths, 4 pointed tooths of each Guan Bi folder are staggered.
2, geared assembly includes at least one pointed tooth and the groove of indent of evagination, and groove and relative folder The quantity mating shapes of the pointed tooth of body, such as groove can be round and smooth grooves, it is also possible to be V-shaped groove;Figure 42 In, each clamp includes 2 pointed tooths and 2 round and smooth grooves, and pointed tooth is corresponding with the round and smooth groove on relative clamp to be set Put.
3, geared assembly includes at least one round and smooth projection of evagination and the round and smooth groove of indent and described round and smooth The round and smooth number of projection mating shapes of groove and relative clamp;In Figure 43, each clamp includes a circle Sliding projection and a round and smooth groove.
Guan Bi folder is clipped in tissue perforation internal orifice peripheral tissues, have hyperelastic Guan Bi folder interior segmental arc or Interior segmental arc and detent projection are jointly treated anastomosed tissue internal orifice and are carried out Self-pressurizing agri, while pressurization, and blood Circulate the tissue scar hyperplasia of good side, make internal orifice heal, reached hurtless measure and internal do not stayed foreign body Purpose.

Claims (10)

1. a titanium Ni-based marmem tissue closure folder, by the Ni-based shape memory alloy material system of titanium Become, it is characterised in that: include the Guan Bi clip main body being made up of the band closed;The band of described Guan Bi is by handing over At least three outer arc segments (91) of staggered arrangement row and interior segmental arc (92) the roundest and the most smooth connection of head and the tail of equal number; Described Guan Bi clip main body is plane layout, disk like layout or bowl-shape layout.
Titanium the most according to claim 1 Ni-based marmem tissue closure presss from both sides, it is characterised in that: The quantity of described outer arc segments (91) is 3,4,5,6 or 8.
Titanium the most according to claim 1 Ni-based marmem tissue closure presss from both sides, it is characterised in that: Described Guan Bi folder also includes being arranged on each interior segmental arc (92) top and pointing to the detent projection at Guan Bi folder center (93)。
Titanium the most according to claim 3 Ni-based marmem tissue closure presss from both sides, it is characterised in that: The quantity of described outer arc segments (91) is 3,4,5,6 or 8.
5. press from both sides according to the titanium Ni-based marmem tissue closure described in claim 1 or 2 or 3 or 4, It is characterized in that: place, the top diameter of a circle of all outer arc segments (91) is 10-20mm, all interior segmental arcs (92) top or top detent projection (93) place diameter of a circle are 1-4mm;Described Guan Bi clip main body Coning angle be 120-180 °.
Titanium the most according to claim 5 Ni-based marmem tissue closure presss from both sides, it is characterised in that: Place, the top diameter of a circle of all outer arc segments (91) is 12-16mm, the top of all interior segmental arcs (92) Or top detent projection (93) place diameter of a circle is 1-3mm;The coning angle of the band of described Guan Bi is 160°。
7. press from both sides according to the titanium Ni-based marmem tissue closure described in claim 1 or 2 or 3 or 4, It is characterized in that: described Guan Bi folder also includes identical with outer arc segments (91) quantity and the most parallel folder; Described parallel folder includes two clamps (94) be arrangeding in parallel;The fixing end of said two clamp (94) divides Other and outer arc segments (91) two ends are connected, and its on-fixed end is positioned at this outer arc segments (91) area defined In.
Titanium the most according to claim 7 Ni-based marmem tissue closure presss from both sides, it is characterised in that: The side that said two clamp (94) is relative is respectively arranged with geared assembly;Described geared assembly includes evagination At least one pointed tooth (941) and described pointed tooth stagger with the tine locations of relative clamp, or outside including The point of convex at least one pointed tooth (941) and the groove (942) of indent and described groove and relative clamp The quantity mating shapes of tooth, or include at least one round and smooth projection (943) of evagination and indent The round and smooth number of projection mating shapes of round and smooth groove (944) and described round and smooth groove and relative clamp.
Titanium the most according to claim 8 Ni-based marmem tissue closure presss from both sides, it is characterised in that: Place, the top diameter of a circle of all outer arc segments (91) is 10-20mm, the top of all interior segmental arcs (92) Or top detent projection (93) place diameter of a circle is 1-4mm;The coning angle of the band of described Guan Bi is 120-180°;The spacing of said two clamp (94) is 0.5-2mm.
Titanium the most according to claim 9 Ni-based marmem tissue closure presss from both sides, it is characterised in that: Place, the top diameter of a circle of all outer arc segments (91) is 12-16mm, the top of all interior segmental arcs (92) Or top detent projection (93) place diameter of a circle is 1-3mm;The coning angle of the band of described Guan Bi is 160°。
CN201610407973.6A 2015-12-22 2016-06-12 The Ni-based marmem tissue closure folder of titanium Active CN105902290B (en)

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PCT/CN2016/111526 WO2017107955A1 (en) 2015-12-22 2016-12-22 Titanium nickel-based shape memory alloy tissue closing clip, release device, and clip accommodating device

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CN2015109709107 2015-12-22

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017107955A1 (en) * 2015-12-22 2017-06-29 杨西群 Titanium nickel-based shape memory alloy tissue closing clip, release device, and clip accommodating device
CN107137119A (en) * 2017-07-04 2017-09-08 安瑞医疗器械(杭州)有限公司 A kind of closing clamp and its method for releasing
CN107374685A (en) * 2017-07-09 2017-11-24 杨西群 Soft tissue set based on marmem cuts stapler
CN107374691A (en) * 2017-07-09 2017-11-24 杨西群 A kind of Ti-Ni marmem hemorrhoid complicated by anal fistula internal orifice closure folder
CN111214271A (en) * 2018-11-27 2020-06-02 杨西群 Variable-diameter shape memory alloy closing clamp and stacked multiple-variable-diameter closing clamp device
CN111214272A (en) * 2018-11-27 2020-06-02 杨西群 Shape memory alloy closure clip and stacked multiple closure clip device
CN112770681A (en) * 2018-09-18 2021-05-07 马鲁霍医药有限公司 Tissue care device and method of use
WO2023184056A1 (en) * 2022-03-28 2023-10-05 江苏唯德康医疗科技有限公司 Medical closing clamp

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CN107137119A (en) * 2017-07-04 2017-09-08 安瑞医疗器械(杭州)有限公司 A kind of closing clamp and its method for releasing
CN107374685A (en) * 2017-07-09 2017-11-24 杨西群 Soft tissue set based on marmem cuts stapler
CN107374691A (en) * 2017-07-09 2017-11-24 杨西群 A kind of Ti-Ni marmem hemorrhoid complicated by anal fistula internal orifice closure folder
CN107374685B (en) * 2017-07-09 2023-08-15 杨西群 Soft tissue sleeve cutting anastomat based on shape memory alloy
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