CN105900996A - Bactericide composition containing metconazole and fluxapyroxad - Google Patents
Bactericide composition containing metconazole and fluxapyroxad Download PDFInfo
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- CN105900996A CN105900996A CN201610547342.4A CN201610547342A CN105900996A CN 105900996 A CN105900996 A CN 105900996A CN 201610547342 A CN201610547342 A CN 201610547342A CN 105900996 A CN105900996 A CN 105900996A
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- Prior art keywords
- fluxapyroxad
- metconazole
- bactericidal composition
- mass ratio
- composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericide composition containing metconazole and fluxapyroxad. The active components of the bactericide composition are metconazole and fluxapyroxad, wherein the mass ratio of metconazole to fluxapyroxad is 1:20 to 20:1, and the mass percentage of the active components in the composition is 5-60%. The bactericide composition has high bactericidal activity, delays the generation and development of drug resistance of pathogens, reduces the preventing and treating dosage in actual production, is economical, efficient, safe and environment-friendly, and has obvious preventing and treating effects on rice sheath blight disease.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, a kind of containing metconazole with the bactericidal composition of fluxapyroxad,
For preventing and treating rice sheath blight disease.
Background technology
Rice sheath blight disease is by the popular disease in the microbial worldwide scope of miliary damping-off, on Ye Shi China Oryza sativa L.
One of most important disease.Its distribution widely, has generation in China each Oryza sativa L. main producing region, especially on ground, the middle and lower reach of Yangtze River
District and South China, harm is very serious, causes yield drastically to decline.Selection-breeding and popularization disease-resistant variety, be preventing and treating rice banded sclerotial blight
One of sick important measures, in recent years, although Chinese scholars achieves a lot of progress in terms of breeding for disease resistance, but there is no at present
Select the rice varieties of immunity complete to rice sheath blight disease.Rhizoctonia solani Kuhn preventing and treating at present is also to rely on chemical control.
China is preventing and treating the medicament having been used up in rice sheath blight disease based on jingganmycin, the most i.e. at rice tillering at present
Diseased plant rate reached about 15% and started to spray medicine preventing and treating latter stage, and achieved certain effect.But have been reported display, China's part
Area rice sheath blight disease has created Drug resistance to jingganmycin, and the prevention effect of this medicament caused constantly declines.If
Continue to control rice sheath blight disease, especially filter out the surrogate-data technique preventing and treating rice sheath blight disease, administer jingganmycin drug resistance simultaneously
Property and promote the sustainable control of rice sheath blight disease, it has also become what numerous scientific workers and Rice Cropping person faced great chooses
War.
Metconazole (Metconazole), is again hydroxyl bacterium azoles, chemical name: 5-(4-chlorphenyl)-2,2-dimethyl-1-(1,
2,4-triazol-1-yl methyl)-cyclopentanol, crystalline solid white, tasteless, for Wu Yu chemical company of Japan in early 1990s
The trendy triazole bactericidal agent of exploitation, for C-14 demethylation enzyme inhibitor in ergosterol biosynthesis, makes somatic cells film
Function is destroyed.Thus, suppress or disturb thalline appresorium and the formation of the growth of haustorium, mycelia and spore, also can cause
Film seepage is aggravated, thus reduces pathogen pathogenicity.Although the mechanism of action is as other triazole bactericidal agents, but activity profile is then
Difference is bigger.Two kinds of isomers have bactericidal activity, but Cis activity is higher than trans.The antifungal of metconazole is composed widely,
And activity is splendid.Metconazole field is used and cereal crops septoria musiva, fusarium and handle rest fungus are planted disease is had excellent effect.Metconazole
Compared with tradition biocide agent, dosage is extremely low and prevent and treat frumentum to plant disease scope the widest.Metconazole be a kind of efficiently, wide spectrum, interior suction
The triazole bactericidal agent of property, has protection, treatment, eradicant action, thus is widely used in being drawn by the fungus such as ascomycetes, basidiomycetes
The preventing and treating of the multiple diseases risen.Metconazole is one of effective agent preventing and treating rice sheath blight disease at present, can not only reduce field water
The severity of the sheath and culm blight of rice, can reduce the pathogenic toxin falling ill in wheat grain simultaneously and pollute, ensure food safety.
Metconazole molecular formula: C17H22ClN3O, structural formula:
Fluxapyroxad (fluxapyroxad), chemical name: 3-(difluoro)-1-methyl-N-(3', 4', 5'-trifluoro [1,
1'-biphenyl]-2-base)-1-H-pyrazoles-4-amide, fluxapyroxad belongs to pyrazole amide series bactericidal agent, and succinate dehydrogenase suppresses
Agent, preventing and treating is had both.It can suppress the Repiration of fungus, suppresses spore-germination, and germ tube extends, mycelial growth and spore shape
Become.Can be used for the multiple fungal disease controlling and suppressing in various crop.By superior lasting effect and lasting transmission characteristic
It is integrated in one.
Fluxapyroxad molecular formula C18H12F5N3O, structural formula is:
Metconazole and fluxapyroxad single dose life-time service, easily make disease develop immunity to drugs, and causes dosage to strengthen, prevents
The problem that effect reduces, the lasting period shortens, is unfavorable for environment sustainable development.And the effective ingredient of the difference mechanism of action carries out multiple
Join, be to delay disease to develop immunity to drugs conventional method, and according to the effect in production application, judge this compounding be to increase
Effect effect or antagonism.The obvious formula of complex role, can significantly improve preventive effect, is substantially reduced the medication of pesticide
Amount, also can expand fungicidal spectrum, improves germicidal efficiency.
Summary of the invention
The invention provides a kind of containing metconazole with the bactericidal composition of fluxapyroxad, there is bactericidal activity high, delay
Pathogen Drug resistance produces and development, and makes dosage total in unit are decline, economic, efficient, environmental protection, in preventing and treating Oryza sativa L.
Specially good effect is had in banded sclerotial blight.
The antibacterial that two classes are had different mechanism of action by the present invention is combined, and is processed into the upper easy-to-use system of production
Agent, is used alone in two kinds of compositions and compares, and has biological activity high, and dosage total in unit are declines, and is substantially reduced
Dispenser cost, delays pathogen Drug resistance to produce to a greater extent and development simultaneously, reduces pathogenic fungi and kill single
Microbial inoculum produces the risk of resistance, extends the service life of each component in bactericidal composition, thus realizes economy, efficient, environmental protection
Goal of the invention.
The technical scheme is that
A kind of containing metconazole with the microbicide compositions of fluxapyroxad, it is characterised in that described microbicide compositions
Active component be the mass ratio of metconazole and fluxapyroxad, metconazole and fluxapyroxad be 1:20 to 20:1, in compositions
Active component weight/mass percentage composition is 5-60%.
It is described containing metconazole and the bactericidal composition of fluxapyroxad, it is characterised in that: described active component leaf bacterium
The mass ratio of azoles and fluxapyroxad is 1:10 to 10:1.
It is described containing metconazole and the bactericidal composition of fluxapyroxad, it is characterised in that: described metconazole and fluorine azoles
The mass ratio of bacterium amide is 1:3-8.
It is described containing metconazole and the bactericidal composition of fluxapyroxad, it is characterised in that: described metconazole and fluorine azoles
The mass ratio of bacterium amide is 1:4-6.
It is described containing metconazole and the microbicide compositions of fluxapyroxad, it is characterised in that: described microbicide compositions
Dosage form be wettable powder, suspending agent or cream.
The described application of the microbicide compositions containing metconazole and fluxapyroxad, it is characterised in that: this antimicrobial combination
Thing is especially pronounced to the prevention effect of rice sheath blight disease.
Remarkable result and the advantage of the present invention be:
The present invention has the highest prevention effect to rice sheath blight disease, there is notable synergistic effect between two components；Can replace
Part high price pesticide species, and reduce dosage, effectively reduces ecological disruption and environmental pollution, and can improve wheat yield and
Quality；In the present invention, metconazole and fluxapyroxad all belong to the toxicity such as low, and to people and animals, beneficial organism, Environmental security；Can prolong
The slow pathogenic bacteria Drug resistance to single medicament.
First metconazole and the EC of fluxapyroxad two single compound (hereinafter referred to as medicament) are measured50(drug safety
Index), according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley method, and according to Wadley coefficient of synergism C
Value, determines suitable compositions ratio, is then verified by the abundant method of Sun Yun.
Test objective thing is Rhizoctonia solani Kuhn, but does not limit so.Test uses mycelial growth algoscopy, by different disposal
Make pastille culture medium, 4 repetitions of each process, after connecing bacterium 3 days, investigate each process and the growth inhibited of Rhizoctonia solani Kuhn is imitated
Really.By the linear regression analysis between probit value and the logarithm value of series drug concentration of preventive effect, obtain the EC of each medicament50,
Calculate coefficient of synergism (SR) according to Wadley method, and make overall merit accordingly.SR≤0.5 represents have antagonism, 0.5 ＜
SR ＜ 1.5 represents have summation action, and SR >=1.5 are potentiation.SR value calculating method is as follows:
EC50(theoretical value)=(a+b)/(a/EC50A+b/EC50B)
SR=EC50(theoretical value)/EC50(actual value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5～1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have potentiation
Table 1 metconazole and the fluxapyroxad compositions Wadley method measurement result to rice sheath blight disease
Note: Y is metconazole, and F is fluxapyroxad.
Can analyze from data above, the metconazole of different proportion and fluxapyroxad compositions are to Rhizoctonia solani Kuhn
Fungistatic effect is different, and on the whole, its ratio has potentiation or addition in the range of 1:20 to 20:1,
Big enhancing proportions is metconazole: fluxapyroxad=5:1.
Below in conjunction with embodiment, the invention will be further described, but is not limited to this.
Detailed description of the invention
Embodiment 1 (preparation method of 60% metconazole fluxapyroxad wettable powder)
Composition of raw materials: by mass percentage
Preparation method is as follows:
According to formula, individual component being weighed in proportion, add ball mill ball milling 30 minutes, filter, suction dispersion tank is at a high speed
Being fully ground through sand mill after shearing 3 minutes, control solid constituent particle diameter, within 2 microns, grinds stirring after terminating equal
Even, obtain suspending agent product.
Embodiment 2 (preparation method of 30% metconazole fluxapyroxad suspending agent)
Preparation method: same as in Example 1.
Embodiment 3 (preparation method of 40% metconazole fluxapyroxad suspending agent)
Preparation method: same as in Example 1.
Embodiment 4 (20% metconazole fluxapyroxad cream)
Preparation method: fully dissolved in dimethylbenzene reactor by active component metconazole, makes A liquid；By active component
Fluxapyroxad is fully dissolved in DMF reactor, makes B liquid；Under not stopping stirring, A liquid is mixed into B liquid, is sufficiently stirred for
Uniformly, add anhydrous calcium salt and NP-10, then adjust content with solvent xylene.
Embodiment 5 (45% metconazole fluxapyroxad cream)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 4.
Embodiment 6 (preparation method of 48% metconazole fluxapyroxad cream)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 4.
Prevention effect is tested:
The field efficiency test of rice sheath blight disease is carried out in suburb, Bengbu, and test area is 0.3hm2, often process repetition
Three times, carrying out spraying medicine preventing and treating latter stage at rice tillering, carry out preventive effect investigation after dispenser 15, preventing and treating the results are shown in Table 2.Result table
Bright, the bactericidal composition containing metconazole and fluxapyroxad has good prevention effect to rice sheath blight disease, at identical dose
Higher prevention effect can be reached under amount or relatively low using dosage, and each process preventive effect bacterium of this bactericidal composition is more than 85%,
It is significantly higher than comparison medicament.
Table 2 metconazole fluxapyroxad bactericidal composition prevents and treats land for growing field crops drug effect * of rice sheath blight disease
It should be noted that when the proportioning of metconazole and fluxapyroxad is 5:1, compared with other process, relatively low
Consumption under but disease is had higher preventive effect, it is shown that preferably synergistic function；And indoor biometrics result also indicates that,
When the proportioning of metconazole and fluxapyroxad is 5:1, the coefficient of synergism measured is the highest, and the result of the two is consistent.
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above.Obviously, this
Bright it is not limited to above embodiment, it is also possible to have many variations.Those of ordinary skill in the art can be in disclosed by the invention
Hold all deformation directly derived or associate, be all considered the scope of protection of the invention.
Claims (6)
1. one kind contains metconazole and the bactericidal composition of fluxapyroxad, it is characterised in that the activity of described microbicide compositions
Component be the mass ratio of metconazole and fluxapyroxad, metconazole and fluxapyroxad be 1:20 to 20:1, in compositions activity
Constituent mass percentage composition is 5-60%.
It is the most according to claim 1 containing metconazole with the bactericidal composition of fluxapyroxad, it is characterised in that: described work
The mass ratio of property component metconazole and fluxapyroxad is 1:10 to 10:1.
It is the most according to claim 1 containing metconazole with the bactericidal composition of fluxapyroxad, it is characterised in that: described leaf
The mass ratio of bacterium azoles and fluxapyroxad is 1:3-8.
It is the most according to claim 1 containing metconazole with the bactericidal composition of fluxapyroxad, it is characterised in that: described leaf
The mass ratio of bacterium azoles and fluxapyroxad is 1:4-6.
It is the most according to claim 1 and 2 containing metconazole with the bactericidal composition of fluxapyroxad, it is characterised in that: described
The dosage form of microbicide compositions is wettable powder, suspending agent or cream.
Bactericidal composition application containing metconazole and fluxapyroxad the most according to claim 1 and 2, it is characterised in that:
Described bactericidal composition has the highest prevention effect to rice banded sclerotial blight disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610547342.4A CN105900996A (en) | 2016-07-12 | 2016-07-12 | Bactericide composition containing metconazole and fluxapyroxad |
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| CN201610547342.4A CN105900996A (en) | 2016-07-12 | 2016-07-12 | Bactericide composition containing metconazole and fluxapyroxad |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106538547A (en) * | 2016-10-13 | 2017-03-29 | 深圳诺普信农化股份有限公司 | Bactericidal composition and its application |
| CN106962363A (en) * | 2017-05-27 | 2017-07-21 | 南京农业大学 | A kind of collaboration decrement bactericidal composition containing metconazole |
| CN107969434A (en) * | 2018-01-08 | 2018-05-01 | 江苏徐淮地区淮阴农业科学研究所 | A kind of bactericidal composition containing metconazole, fluxapyroxad and pyraclostrobin |
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| CN102014621A (en) * | 2008-05-09 | 2011-04-13 | 巴斯夫欧洲公司 | Process for the production of particles comprising active agrochemical ingredients in amorphous form |
| CN103228134A (en) * | 2010-11-25 | 2013-07-31 | 巴斯夫欧洲公司 | Waterless composition comprising pesticide and copolymers with sulfonic acid groups |
| US20140200140A1 (en) * | 2013-12-30 | 2014-07-17 | Sumitomo Chemical Company, Limited | Method of controlling pests |
| CN104202978A (en) * | 2012-04-04 | 2014-12-10 | 巴斯夫欧洲公司 | Agroformulation comprising copolymer of vinyllactam, N-alkyl acrylamide, and alkyl (meth)acrylate |
| US20150157017A1 (en) * | 2013-12-06 | 2015-06-11 | Sumitomo Chemical Company, Limited | Method of controlling pests |
-
2016
- 2016-07-12 CN CN201610547342.4A patent/CN105900996A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102014621A (en) * | 2008-05-09 | 2011-04-13 | 巴斯夫欧洲公司 | Process for the production of particles comprising active agrochemical ingredients in amorphous form |
| CN103228134A (en) * | 2010-11-25 | 2013-07-31 | 巴斯夫欧洲公司 | Waterless composition comprising pesticide and copolymers with sulfonic acid groups |
| CN104202978A (en) * | 2012-04-04 | 2014-12-10 | 巴斯夫欧洲公司 | Agroformulation comprising copolymer of vinyllactam, N-alkyl acrylamide, and alkyl (meth)acrylate |
| US20150157017A1 (en) * | 2013-12-06 | 2015-06-11 | Sumitomo Chemical Company, Limited | Method of controlling pests |
| US20140200140A1 (en) * | 2013-12-30 | 2014-07-17 | Sumitomo Chemical Company, Limited | Method of controlling pests |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106538547A (en) * | 2016-10-13 | 2017-03-29 | 深圳诺普信农化股份有限公司 | Bactericidal composition and its application |
| CN106962363A (en) * | 2017-05-27 | 2017-07-21 | 南京农业大学 | A kind of collaboration decrement bactericidal composition containing metconazole |
| CN107969434A (en) * | 2018-01-08 | 2018-05-01 | 江苏徐淮地区淮阴农业科学研究所 | A kind of bactericidal composition containing metconazole, fluxapyroxad and pyraclostrobin |
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