CN105833131A - Preparation for treating gastric ulcer and duodenal ulcer and preparation method - Google Patents
Preparation for treating gastric ulcer and duodenal ulcer and preparation method Download PDFInfo
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Abstract
The invention discloses a preparation for treating gastric ulcer and duodenal ulcer. The preparation is prepared from, by weight, 3-6 parts of polygonum capitatum Buch.-Ham.exD.Don, 1-4 parts of flowers of Japanese roses, 7-11 parts of rhizoma bletillae, 9-11 parts of rhizome of broadsheath greenbrier, 2-4 parts of hematite, 8.5-11.5 parts of radix codonopsis, 4-6 parts of Indian trumetflower seeds, 3-7 parts of rhizome of common lophantherum, 11-14 parts of roots of buerger raspberries, 6-8 parts of rhizome of perny false fairybells, 5-7 parts of bark of lindenleaf torricellia, 7-13 parts of symplocos sumuntia Buch.-Ham.ex D.Don[S.Caudata Wall.], 4-8 parts of radix linderae leaves, 1-4 parts of roots or leaves of apricot plum and 4.5-8.5 parts of herbs of peltateleaf meadowrue. The preparation has the advantages that traditional drug properties are organically combined with modern pharmacology of traditional Chinese medicine, medicine is used to form a formula, the curative effect is enhanced, all types of medicine are combined, and the effects of helping digestion, resolving stagnation, promoting the circulation of qi, removing distension and the like are achieved.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of cure gastric ulcer and the preparation of duodenal ulcer and
Preparation method.
Background technology
Gastric ulcer and duodenal ulcer are the common diseases in clinic, and its main topical manifestations is stomach and duodenal wall
Limitation round defect or oval defect occur.Patient is mainly with periodic epigastrium pain, belch and turn sour
Etc. clinical symptoms.Wherein, epigastrium pain mainly includes the symptoms such as causalgia, dull pain, severe pain and distending pain, it is possible to show as patient
The symptom that dull pain is uncomfortable occurs after being in starvation.This disease has repeatability outbreak, the feature of chronic process.Duodenum is burst
The sickness rate of infections accounts for 70%, and the sickness rate of gastric ulcer accounts for 25%, and both and the combined Peptic Ulcer deposited account for 5%.Hemorrhage, perforation
And pyloric obstruction is the common complication of gastric and duodenal ulcers.Continuous along with gastric and duodenal ulcers Therapeutic Method
Innovation, the clinical cure rate of peptic ulcer is greatly improved, but easily recurs after drug withdrawal.
Gastric ulcer and duodenal ulcer are a kind of multi-factor diseases, and the cause of disease is complicated, and the clearest and the most definite cause of disease is and smoking,
Drink, take non-steroidal drug, diet irregular diet, work and rest irregular, stay up late for a long time etc. bad diet and living habit relevant.
A good appetite suddenly appearing in a serious disease has beyond epigastrium pain symptom, the most often has other gastrointestinal symptoms concurrently, such as belch, acid regurgitation, heartburn, Nausea and vomiting
Deng, onset is the slowest, and the course of disease is up to several years or many decades, in periodical attack, has a strong impact on Health and Living, multiple epimegetic
Ulcer can occur canceration.In recent years clinical onset rate has the trend of constantly rising.The morbidity of primary disease is relevant to liver-spleen disharmony, and liver is lost and dredges
Let out then dysfunction of the spleen in transportation, gastropathy and spleen and then hinder fortune, and the spleen-stomach disease can relate to liver, causes the stagnation of QI；Furthermore the generation polydipsia drink of primary disease
Food does not saves, and tobacco and wine are excessive, the pungent irritable food of surfeit, and feelings will is the most smooth, and weakness of the spleen and stomach is the pathogenesis basis of this disease, the stagnation of QI
Blood stasis is common pathogenesis, and the damage of stomach network is basic lesion feature.
Application publication number CN 104873663 A(application number 201510196623.5) Chinese invention patent document open
A kind of Chinese medicine composition for treating taste-blindness rate, the weight portion of constitutive material is: Flos Plumeriae Acutifoliae 90-110, dragon
Radix Gentianae 4-6, Endoconcha Sepiae 18-25, Radix Bupleuri 5-10, Herba Epimedii 5, Pollen Typhae 8-12, Pericarpium Citri Reticulatae 5-10, Corium Erinacei Seu Hemiechianus 1-3, Nodus Nelumbinis Rhizomatis 4-6, Massa Medicata Fermentata
8-12, Os Sepiae 4-6, Endothelium Corneum Gigeriae Galli 8, Rhizoma Corydalis 8-12, Radix Glycyrrhizae 8-12, Radix Callicarpae longissimae 2-4, Cortex Podocarpii Szechuenensis Radicis 4-6, Mentholum 0.5-
1.5.Application publication number CN 103961632 A(application number 201410233301.9) Chinese invention patent document disclose
A kind of Chinese medicine composition treating gastric and duodenal ulcers, is made up of the raw material of Chinese medicine of following weight proportion: Fructus Tribuli 10-20
Part, Rhizoma Cyperi 5-15 part, Rhizoma Atractylodis (parched) 5-15 part, Rhizoma Chuanxiong 5-10 part, Bulbus Fritillariae Thunbergii 15-30 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Os Sepiae 5-15 part,
Radix Codonopsis 10-25 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Poria 20-40 part, Fructus Evodiae 15-30 part, Flos Inulae 5-15 part, Fructus Amomi 5-15 part,
Radix Glycyrrhizae 10-20 part.Application publication number CN 103735786 A(application number 201310747640.4) Chinese invention patent literary composition
Offer and disclose a kind of Chinese medicine composition treating gastric and duodenal ulcers, be made up of following crude drug: Rhizoma Dioscoreae 12 parts-15 parts,
Fructus Citri Sarcodactylis 16 parts-18 parts, vinegar-fried Rhizoma Corydalis 8 parts-10 parts, vinegar Concha Arcae (calcined) 12 parts-15 parts, the Radix Paeoniae Alba 10 parts-12 parts, Radix Bupleuri 10 part-12
Part.
The medicament categories for the treatment of gastric ulcer and duodenal ulcer is various in the market, but most of effect is slow or medicine
Imitating undesirable, some medicines are easily caused other complication, add the misery of patient, extend treatment time.Therefore study
A kind of safe and effective, medicine without any side effects is the most necessary.
Summary of the invention
For the deficiencies in the prior art, it is an object of the invention to provide one and prepare simply, conveniently take, safely and effectively
Cure gastric ulcer and the preparation of duodenal ulcer.Invention formulation is evident in efficacy and without any side effects, it is simple to clinical practice.
The technical scheme is that
Cure gastric ulcer and the preparation of duodenal ulcer, take following raw materials according and be prepared from, be weight portion: Herba Polygoni Capitati 3-6；Rose
Common vetch flower 1-4；Pseudobulbus Bletillae (Rhizoma Bletillae) 7-11；Rhizoma Smilacis discotis 9-11；Haematitum 2-4；Radix Codonopsis 8.5-11.5；Semen Oroxyli 4-6；Rhizoma lophantheri 3-7；The cold certain kind of berries
Root 11-14；Rhizoma disporopsis pernyi 6-8；Cortex torricelliae tiliifoliae 5-7；Radix Symplocoris Caudatae 7-13；Folium Linderae strychnifoliae 4-8；Radix seu Folium pruni simenii 1-4；Herba Thalictri Ichangensis 4.5-8.5.
Preferably in scheme, Herba Polygoni Capitati 4-5；Flos rosae multiflorae 2-3；Pseudobulbus Bletillae (Rhizoma Bletillae) 8-10；Rhizoma Smilacis discotis 9.5-10.5；Haematitum 2.5-
3.5；Radix Codonopsis 9-11；Semen Oroxyli 4.5-5.5；Rhizoma lophantheri 4-6；Radix rubi buergeri 12-13；Rhizoma disporopsis pernyi 6.5-7.5；Cortex torricelliae tiliifoliae 5.5-6.5；
Radix Symplocoris Caudatae 9-11；Folium Linderae strychnifoliae 5-7；Radix seu Folium pruni simenii 2-3；Herba Thalictri Ichangensis 5.5-7.5.
More preferably, Herba Polygoni Capitati 4.5；The Flos rosae multiflorae 2.5；Pseudobulbus Bletillae (Rhizoma Bletillae) 9；Rhizoma Smilacis discotis 10；Haematitum 3；Radix Codonopsis 10；Semen Oroxyli
5；Rhizoma lophantheri 5；Radix rubi buergeri 12.5；Rhizoma disporopsis pernyi 7；Cortex torricelliae tiliifoliae 6；Radix Symplocoris Caudatae 10；Folium Linderae strychnifoliae 6；Radix seu Folium pruni simenii 2.5；Herba Thalictri Ichangensis 6.5.
Curing the preparation method of the preparation granules agent of gastric ulcer and duodenal ulcer, step is as follows:
(1) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.25-0.45 times amount of 0.4-0.7 times amount
(preferably adding yellow wine and the rice vinegar of 0.35 times amount of 0.55 times amount), slow fire boiling 10-20 minute (preferably slow fire boiling 15 minutes),
Take out, dry, be ground into fine powder, standby；
(2) Folium Linderae strychnifoliae, the Flos rosae multiflorae and Radix seu Folium pruni simenii being mixed, the Mel adding 0.16-0.30 times amount (preferably adds the honeybee of 0.25 times amount
Honey), mix thoroughly, vexed 6-10 minute (the most vexed 8 minutes), then slow fire add propagandize hotly to tack-free for degree, take out, standby；
(3) crude drug after step (2) being processed together is placed in frying pan with Herba Polygoni Capitati, Semen Oroxyli, Herba Thalictri Ichangensis and Rhizoma disporopsis pernyi, adds
The clear water (preferably adding the clear water of 7 times amount) of 5.5-8.5 times amount, slow fire boiling 40-60 minute (preferably slow fire boiling 50 minutes), mistake
Filter, filtrate reduced in volume to 80 DEG C relative density is the clear paste of 1.22-1.25, standby；
(4) Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Smilacis discotis, Radix Codonopsis, Rhizoma lophantheri, Radix rubi buergeri, Cortex torricelliae tiliifoliae and Radix Symplocoris Caudatae fully be dry, pulverize into fine powder,
Mix with step (1) gained fine powder, sieve, obtain mixing fine powders, standby；
(5) step (4) gained mixing fine powders is joined in step (3) gained clear paste, add other adjuvant while stirring, mixed
Even, make bead dosage form according to the processing method of granule, to obtain final product.
The preparation method of the preparation granules agent of above-mentioned treatment gastric ulcer and duodenal ulcer, preferred scheme is, step
(4) mistake 100-140 mesh sieve (preferred 110-130 mesh sieve, mistake 120 mesh sieve more preferably excessively).
The preparation method of the preparation granules agent of above-mentioned treatment gastric ulcer and duodenal ulcer, preferred scheme is, step
(5) described adjuvant be mass fraction be 4.5% ethyl cellulose and mass fraction be the Polyethylene Glycol of 1.9%.
The preparation method of described capsule is:
(1) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.25 times amount, the slow fire boiling of 0.4 times amount
10 minutes, take out, dry, be ground into fine powder, standby；
(2) Folium Linderae strychnifoliae, the Flos rosae multiflorae and Radix seu Folium pruni simenii are mixed, add the Mel of 0.16 times amount, mix thoroughly, vexed 6 minutes, then slow fire heating
Fry and take out for spending to tack-free, dry, be ground into fine powder, standby；
(3) Semen Oroxyli, Cortex torricelliae tiliifoliae, Radix Symplocoris Caudatae and Rhizoma Smilacis discotis are mixed, add the ethanol sealing extraction that concentration is 50%-80% (excellent
Choosing adds the ethanol that concentration is 65% and seals extraction), collect lixiviating solution, reclaim ethanol, through concentrating under reduced pressure, be dried, obtain sepia thin
Powder, standby；
(4) by the crude drug boiling in addition to step (1)-(3) twice, the clear water (preferably the of 8-10 times amount is added for the first time
Once add the clear water of 9 times amount), slow fire boiling 40-50 minute (preferably slow fire boiling 45 minutes), filter, medicinal residues add 3-6 times amount again
Clear water (preferably medicinal residues add the clear water of 4.5 times amount again), slow fire boiling 20-30 minute (preferably slow fire boiling 25 minutes), filter,
Merging twice filtrate, concentrating under reduced pressure becomes thick paste, standby；
(5) step (1)-(3) gained fine powder is joined in above-mentioned thick paste, mixing, it is spray-dried, granulate, loads capsule shells, i.e.
?.
The preparation method of the preparation capsule of above-mentioned treatment gastric ulcer and duodenal ulcer, preferred scheme is, step
(3) extraction time is 15-25 hour (preferred extraction time is 18-22 hour, and extraction time more preferably is 20 hours).
The preparation method of described tablet is:
(1) Semen Oroxyli, Cortex torricelliae tiliifoliae, Radix Symplocoris Caudatae and Rhizoma Smilacis discotis are mixed, add the ethanol that concentration is 50% and seal extraction 20 hours,
Collect lixiviating solution, reclaim ethanol, through concentrating under reduced pressure, be dried, obtain sepia fine powder, standby；
(2) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.3 times amount, the slow fire boiling of 0.5 times amount
15 minutes, take out, dry, be ground into fine powder, standby；
(3) crude drug in addition to step (1) and (2) is placed in frying pan, adds cold water and do not had powder 3-5cm, soak 3-6 hour
(preferably soaking 4.5 hours), then big fire heated and boiled, turn little fire and decoct 32-48 minute (preferably turning little fire to decoct 40 minutes),
Filtering, filtrate reduced in volume becomes thick paste, is spray-dried the powder that gets dry extract, standby；
(4) by step (1)-(3) process after raw material mixing, add mass fraction be 3% amylum pregelatinisatum and mass fraction be
The magnesium stearate of 1.5%, mixing, cross 70-90 mesh sieve (preferably crossing 80 mesh sieves), make tablet according to the processing mode of tablet, i.e.
?.
The preparation method of described water preparation is:
(1) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.3 times amount, the slow fire boiling of 0.5 times amount
15 minutes, take out, dry, be ground into fine powder, cross 140-160 mesh sieve (preferably crossing 150 mesh sieves), standby；
(2) Folium Linderae strychnifoliae, the Flos rosae multiflorae and Radix seu Folium pruni simenii being mixed, add the Mel of 0.25 times amount, mix thoroughly, vexed 10 minutes, then slow fire added
Propagandize hotly and take out for spending to tack-free, standby；
(3) crude drug after step (2) being processed and Herba Polygoni Capitati, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Smilacis discotis, Radix Codonopsis, Semen Oroxyli, Rhizoma lophantheri, the cold certain kind of berries
Root, Rhizoma disporopsis pernyi, Cortex torricelliae tiliifoliae, Radix Symplocoris Caudatae and Herba Thalictri Ichangensis are together placed in frying pan, and the clear water adding 9-11 times amount (preferably adds 10 times amount
Clear water), big fire is heated to boiling, turns little fire and decocts 38-60 minute (preferably turning little fire to decoct 50 minutes), filters, and filtrate decompression is dense
It is reduced to the 1/2 of original volume, standby；
(4) joining in step (3) gained filtrate by step (1) gained fine powder, mixing, sterilizing encapsulates, to obtain final product.
Scientific formula of the present invention, preparation method is simple, taking convenience, safely and effectively.In addition, the excellent effect of the present invention
Fruit is also manifested by:
1, the tradition property of medicine is organically combined by the present invention with Chinese medicine modern pharmacology, using drugs to form a prescription, promotes curative effect, and all medicines share to have and disappear
The effects such as food, intestinal stasis relieving, circulation of qi promoting, de-swelling；
2, medicine of the present invention is on the basis for the treatment of gastric ulcer and duodenal ulcer, additionally it is possible to improve gastric motility, recovers stomach
Eubolism, long action time, short treating period, instant effect, safe without toxic side effect；
3, medicine source of the present invention is easy to get, and medical material is with low cost, determined curative effect, has higher promotional value.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Embodiment 1 cures the preparation of gastric ulcer and duodenal ulcer, takes following raw materials according and is prepared from, is weight portion
(800g/ part): Herba Polygoni Capitati 3 parts；The Flos rosae multiflorae 1 part；Pseudobulbus Bletillae (Rhizoma Bletillae) 7 parts；Rhizoma Smilacis discotis 9 parts；Haematitum 2 parts；Radix Codonopsis 8.5 parts；Semen Oroxyli 4
Part；Rhizoma lophantheri 3 parts；Radix rubi buergeri 11 parts；Rhizoma disporopsis pernyi 6 parts；Cortex torricelliae tiliifoliae 5 parts；Radix Symplocoris Caudatae 7 parts；Folium Linderae strychnifoliae 4 parts；Radix seu Folium pruni simenii 1 part；Rock
Besom 4.5 parts.
The preparation method of the preparation granules agent curing gastric ulcer and duodenal ulcer is:
(1) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.25 times amount, the slow fire boiling of 0.4 times amount
10 minutes, take out, dry, be ground into fine powder, standby；
(2) Folium Linderae strychnifoliae, the Flos rosae multiflorae and Radix seu Folium pruni simenii are mixed, add the Mel of 0.16 times amount, mix thoroughly, vexed 6 minutes, then slow fire heating
Fry and take out for spending to tack-free, standby；
(3) crude drug after step (2) being processed together is placed in frying pan with Herba Polygoni Capitati, Semen Oroxyli, Herba Thalictri Ichangensis and Rhizoma disporopsis pernyi, adds
The clear water of 5.5 times amount, slow fire boiling 40 minutes, filter, filtrate reduced in volume to 80 DEG C relative density is the clear of 1.22-1.25
Cream, standby；
(4) Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Smilacis discotis, Radix Codonopsis, Rhizoma lophantheri, Radix rubi buergeri, Cortex torricelliae tiliifoliae and Radix Symplocoris Caudatae fully be dry, pulverize into fine powder,
Mix with step (1) gained fine powder, cross 100 mesh sieves, obtain mixing fine powders, standby；
(5) step (4) gained mixing fine powders is joined in step (3) gained clear paste, add other adjuvant, adjuvant while stirring
Ethyl cellulose and mass fraction for mass fraction is 4.5% are the Polyethylene Glycol of 1.9%, and mixing, according to the processing of granule
Method makes bead dosage form, to obtain final product.
The instructions of taking of gained granule of the present invention is: three times a day, each 15-20g, and warm water is taken after mixing it with water, treatment in 7 days
Journey.
Embodiment 2 cures the preparation of gastric ulcer and duodenal ulcer, takes following raw materials according and is prepared from, is weight portion
(600g/ part): Herba Polygoni Capitati 6 parts；The Flos rosae multiflorae 4 parts；Pseudobulbus Bletillae (Rhizoma Bletillae) 11 parts；Rhizoma Smilacis discotis 11 parts；Haematitum 4 parts；Radix Codonopsis 11.5 parts；Wood butterfly
Butterfly 6 parts；Rhizoma lophantheri 7 parts；Radix rubi buergeri 14 parts；Rhizoma disporopsis pernyi 8 parts；Cortex torricelliae tiliifoliae 7 parts；Radix Symplocoris Caudatae 13 parts；Folium Linderae strychnifoliae 8 parts；Radix seu Folium pruni simenii 4
Part；Herba Thalictri Ichangensis 8.5 parts.
The preparation method of the preparation capsule curing gastric ulcer and duodenal ulcer is:
(1) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.25 times amount, the slow fire boiling of 0.4 times amount
10 minutes, take out, dry, be ground into fine powder, standby；
(2) Folium Linderae strychnifoliae, the Flos rosae multiflorae and Radix seu Folium pruni simenii are mixed, add the Mel of 0.16 times amount, mix thoroughly, vexed 6 minutes, then slow fire heating
Fry and take out for spending to tack-free, dry, be ground into fine powder, standby；
(3) Semen Oroxyli, Cortex torricelliae tiliifoliae, Radix Symplocoris Caudatae and Rhizoma Smilacis discotis are mixed, add the ethanol that concentration is 65% and seal extraction 20 hours,
Collect lixiviating solution, reclaim ethanol, through concentrating under reduced pressure, be dried, obtain sepia fine powder, standby；
(4) by the crude drug boiling in addition to step (1)-(3) twice, the clear water of 9 times amount, slow fire boiling 45 are added for the first time
Minute, filtering, medicinal residues add the clear water of 4.5 times amount, slow fire boiling 25 minutes again, filter, merge twice filtrate, and concentrating under reduced pressure becomes thick
Cream, standby；
(5) step (1)-(3) gained fine powder is joined in above-mentioned thick paste, mixing, it is spray-dried, granulate, loads capsule shells, i.e.
?.
The instructions of taking of gained capsule of the present invention is: three times a day, each 3-4 grain, and warm water takes, 7 days courses for the treatment of.
Model case: journey XX, female, 49 years old, people from Laiwu.Patient is to our hospital on July 20th, 2013.Patient's readme:
Stomachache continues to have a surplus for 2 months, and after feed, pain increases the weight of, and with pantothenic acid, Nausea and vomiting, once drug administration treatment, symptom has been delayed
Solve, recur after drug withdrawal；Come my institute after being introduced and check treatment.Check: patient's burning pain in the epigastrium, bitterly gesture are urgent, eat i.e. pain, general
Acid is noisy, xerostomia accent, irritable, constipation.Red tongue with yellow fur, wiry and frequent pulse.It is diagnosed as stomach through gastrointestinal tract x-ray barium meal examination
Ulcer.
Take the present embodiment gained and cure gastric ulcer and the preparation capsule of duodenal ulcer, instructions of taking: every day three
Secondary, each 3-4 grain, warm water takes, 7 days courses for the treatment of.After one course for the treatment of of medication, patient suffers from abdominal pain and substantially alleviates, patient mental's shape
State is clearly better, and partial symptoms and sign disappear, and continues two courses for the treatment of of medication, and patient fully recovers.Pay a return visit after three months, without recurrence.
Embodiment 3 cures the preparation of gastric ulcer and duodenal ulcer, takes following raw materials according and is prepared from, is weight portion
(750g/ part): Herba Polygoni Capitati 4 parts；The Flos rosae multiflorae 2 parts；Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts；Rhizoma Smilacis discotis 9.5 parts；Haematitum 2.5 parts；Radix Codonopsis 9 parts；Wood butterfly
Butterfly 4.5 parts；Rhizoma lophantheri 4 parts；Radix rubi buergeri 12 parts；Rhizoma disporopsis pernyi 6.5 parts；Cortex torricelliae tiliifoliae 5.5 parts；Radix Symplocoris Caudatae 9 parts；Folium Linderae strychnifoliae 5 parts；Sanguis Gallus domesticus
Lee 2 parts；Herba Thalictri Ichangensis 5.5 parts.
The preparation method of the formulation tablet curing gastric ulcer and duodenal ulcer is:
(1) Semen Oroxyli, Cortex torricelliae tiliifoliae, Radix Symplocoris Caudatae and Rhizoma Smilacis discotis are mixed, add the ethanol that concentration is 50% and seal extraction 20 hours,
Collect lixiviating solution, reclaim ethanol, through concentrating under reduced pressure, be dried, obtain sepia fine powder, standby；
(2) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.3 times amount, the slow fire boiling of 0.5 times amount
15 minutes, take out, dry, be ground into fine powder, standby；
(3) crude drug in addition to step (1) and (2) is placed in frying pan, adds cold water and do not had powder 3-5cm, soak 4.5 little
Time, then big fire heated and boiled, turn little fire and decoct little fire decoction 40 minutes, filter, filtrate reduced in volume becomes thick paste, is spray-dried
Get dry extract powder, standby；
(4) by step (1)-(3) process after raw material mixing, add mass fraction be 3% amylum pregelatinisatum and mass fraction be
The magnesium stearate of 1.5%, mixing, cross 80 mesh sieves, make tablet according to the processing mode of tablet, to obtain final product.
The instructions of taking of gained tablet of the present invention is: three times a day, each 4-5 sheet, and warm water takes, 7 days courses for the treatment of.
Embodiment 4 cures the preparation of gastric ulcer and duodenal ulcer, takes following raw materials according and is prepared from, is weight portion
(650g/ part): Herba Polygoni Capitati 5 parts；The Flos rosae multiflorae 3 parts；Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts；Rhizoma Smilacis discotis 10.5 parts；Haematitum 3.5 parts；Radix Codonopsis 11 parts；Wood
Butterfly 5.5 parts；Rhizoma lophantheri 6 parts；Radix rubi buergeri 13 parts；Rhizoma disporopsis pernyi 7.5 parts；Cortex torricelliae tiliifoliae 6.5 parts；Radix Symplocoris Caudatae 11 parts；Folium Linderae strychnifoliae 7 parts；
Radix seu Folium pruni simenii 3 parts；Herba Thalictri Ichangensis 7.5 parts.
The preparation method of the preparation water preparation curing gastric ulcer and duodenal ulcer is:
(1) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.3 times amount, the slow fire boiling of 0.5 times amount
15 minutes, take out, dry, be ground into fine powder, cross 150 mesh sieves, standby；
(2) Folium Linderae strychnifoliae, the Flos rosae multiflorae and Radix seu Folium pruni simenii being mixed, add the Mel of 0.25 times amount, mix thoroughly, vexed 10 minutes, then slow fire added
Propagandize hotly and take out for spending to tack-free, standby；
(3) crude drug after step (2) being processed and Herba Polygoni Capitati, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Smilacis discotis, Radix Codonopsis, Semen Oroxyli, Rhizoma lophantheri, the cold certain kind of berries
Root, Rhizoma disporopsis pernyi, Cortex torricelliae tiliifoliae, Radix Symplocoris Caudatae and Herba Thalictri Ichangensis are together placed in frying pan, add the clear water of 10 times amount, and big fire is heated to boiling, turn
Little fire decocts 50 minutes, filters, the 1/2 of filtrate reduced in volume to original volume, standby；
(4) joining in step (3) gained filtrate by step (1) gained fine powder, mixing, sterilizing encapsulates, to obtain final product.
The instructions of taking of gained water preparation of the present invention is: twice daily, each 120-150mL, and warm is taken, treatment in 7 days
Journey.
Model case: old XX, man, 60 years old, people from Dezhou.Patient is to our hospital on April 13rd, 2014.Patient's readme is near
Abdominal part sensation of fullness, constriction, singultus, belch, pantothenic acid and the malaise symptoms such as heartburn occur after feed in three months, and often feels like muddy
Body is unable, has a strong impact on sleep and appetite；Being diagnosed as gastric ulcer, duodenal ulcer in local hospital inspection, drug administration is controlled
After treatment, symptom has no alleviation；Introduce my institute by neighbours and check treatment.Check: patient's epigastrium pain is obvious, and eructating foul odor is told
Acid, hands and feet being not warm, corpulent tongue is big, the white deep and weak pulse of tongue.It is diagnosed as duodenal ulcer by x-ray barium meal examination.
Take the present embodiment gained and cure gastric ulcer and the preparation water preparation of duodenal ulcer, instructions of taking: twice daily,
Every time 120-150mL, warm takes, 7 days courses for the treatment of.After treating two courses for the treatment of, patient suffers from abdominal pain and substantially alleviates, nauseating, acid regurgitation
Phenomenon disappears；After continuing one course for the treatment of of medication, patient's ulcer surface gradually heals, and patients symptomatic releases, and checks after three months, without multiple
Send out.
Embodiment 5 cures the preparation of gastric ulcer and duodenal ulcer, takes following raw materials according and is prepared from, is weight portion
(700g/ part): Herba Polygoni Capitati 4.5 parts；The Flos rosae multiflorae 2.5 parts；Pseudobulbus Bletillae (Rhizoma Bletillae) 9 parts；Rhizoma Smilacis discotis 10 parts；Haematitum 3 parts；Radix Codonopsis 10 parts；Wood
Butterfly 5 parts；Rhizoma lophantheri 5 parts；Radix rubi buergeri 12.5 parts；Rhizoma disporopsis pernyi 7 parts；Cortex torricelliae tiliifoliae 6 parts；Radix Symplocoris Caudatae 10 parts；Folium Linderae strychnifoliae 6 parts；Sanguis Gallus domesticus
Lee 2.5 parts；Herba Thalictri Ichangensis 6.5 parts.
The preparation method of the preparation granules agent curing gastric ulcer and duodenal ulcer is:
(1) Haematitum being broken into fritter, be placed in frying pan, add yellow wine and the rice vinegar of 0.35 times amount of 0.55 times amount, slow fire is decocted
Boil 15 minutes, take out, dry, be ground into fine powder, standby；
(2) Folium Linderae strychnifoliae, the Flos rosae multiflorae and Radix seu Folium pruni simenii are mixed, add the Mel of 0.25 times amount, mix thoroughly, vexed 8 minutes, then slow fire heating
Fry and take out for spending to tack-free, standby；
(3) crude drug after step (2) being processed together is placed in frying pan with Herba Polygoni Capitati, Semen Oroxyli, Herba Thalictri Ichangensis and Rhizoma disporopsis pernyi, adds
The clear water of 7 times amount, slow fire boiling 50 minutes, filter, filtrate reduced in volume to 80 DEG C relative density is the clear paste of 1.22-1.25,
Standby；
(4) Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Smilacis discotis, Radix Codonopsis, Rhizoma lophantheri, Radix rubi buergeri, Cortex torricelliae tiliifoliae and Radix Symplocoris Caudatae fully be dry, pulverize into fine powder,
Mix with step (1) gained fine powder, cross 120 mesh sieves, obtain mixing fine powders, standby；
(5) step (4) gained mixing fine powders is joined in step (3) gained clear paste, add other adjuvant, adjuvant while stirring
Ethyl cellulose and mass fraction for mass fraction is 4.5% are the Polyethylene Glycol of 1.9%, and mixing, according to the processing of granule
Method makes bead dosage form, to obtain final product.
The instructions of taking of gained granule of the present invention is: three times a day, each 15-20g, and warm water is taken after mixing it with water, treatment in 7 days
Journey.
Herba Polygoni Capitati: Ji Yuan: for the herb of polygonaceae plant Herba Polygoni Capitati.Nature and flavor: toil, temperature.Function cures mainly: removing toxic substances, dissipating blood stasis, profit
Urinate treating stranguria.Control dysentery, pyelitis, cystitis, lithangiuria, rheumatalgia, traumatic injury, skin infection eczema.Chemical analysis: Herba Polygoni Capitati
Herb contains benzaldehyde, acetic acid, 24-hydroxyl lignocerane-3-ketone, 29-hydroxyl nonacosane-3-ketone, cupreol, Galla Turcica (Galla Helepensis)
Acid.
The Flos rosae multiflorae: Ji Yuan: for the flower of rosaceous plant Flos rosae multiflorae.Chemical analysis: the volatile oil of flower contains 28 kinds of compounds, its
In be mainly composed of 2,5,5-trimethyl heptadiene, gemic acid methyl ester etc..Nature and flavor: bitter, puckery；Cool.Gui Jing: stomach；Large intestine channel.Merit
Can cure mainly: clearing away summer-heat, stomach function regulating, promoting blood circulation and hemostasis, removing toxic substances.Main summer-heat excessive thirst；Epigastric distension and distress, spits blood, and epistaxis, aphtha, carbuncle furuncle, menstruation is not
Adjust.
Pseudobulbus Bletillae (Rhizoma Bletillae): Ji Yuan: for the tuber of orchid Pseudobulbus Bletillae (Rhizoma Bletillae).Chemical analysis: fresh tuber moisture content 14.6%, starch
30.48%, glucose 1.5%.Again containing volatile oil, phlegmatic temperament.Root contains bletilla mannan, is by 4 parts of mannose and 1 portion of Fructus Vitis viniferae
The glucomannan of sugar composition.Nature and flavor: bitter sweet are cool.Gui Jing: enter lung meridian.Function cures mainly: tonifying the lung, hemostasis, detumescence, and granulation promoting is held back
Skin ulcer.Controlling lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.
Rhizoma Smilacis discotis: Ji Yuan: for the rhizome of liliaceous plant torr handle Rhizoma Smilacis Chinensis.Nature and flavor: pungent；Bitter；Cool.Function cures mainly: dispel the wind；
Heat clearing away；Dampness removing；Cooling blood for hemostasis.Main air damp-heat arthralgia；Foot swelling and pain in knee；Stranguria with blood；Metrorrhagia.
Haematitum: Ji Yuan: for the Ore of oxide-based mineral bloodstone.Chemical analysis: main containing iron sesquioxide, Qi Zhongtie
70%, oxygen 30%, the most impure titanium, magnesium, aluminum, silicon and moisture.Nature and flavor: bitter, sweet, flat.Gui Jing: return liver, stomach, heart born of the same parents' warp.Merit
Can cure mainly: suppressing the hyperactive liver town is inverse, cooling blood for hemostasis.Control eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spit blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, collapses
Leakage leukorrhagia.
Radix Codonopsis: Ji Yuan: this product is Campanulaceae Radix Codonopsis, element flower Radix Codonopsis or the dry root of radix codonpsis tangshen.Chemical analysis: Radix Codonopsis
Root is containing Saponin, Alkaloid, sucrose, glucose, inulin, starch, mucus and resin etc..Nature and flavor: sweet are flat.Gui Jing: return spleen,
Lung meridian.Effect: invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung.Curing mainly: for deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, interior-heat
Quench one's thirst.
Semen Oroxyli: Ji Yuan: for the dry mature seed of Bignoniaceae plant oroxylum indicum.Nature and flavor: bitter, cold.Gui Jing: enter lung, liver
Warp.Function cures mainly: lung moistening, soothing liver-QI, stomach function regulating, granulation promoting.Controlling cough, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach, the open sore part is not held back.
Rhizoma lophantheri: source: for rhizome and the tuber of grass Herba Lophatheri.Chemical analysis: rhizome Arundoin and print
Cylindrin.Nature and flavor: sweet；Cold.Function cures mainly: clearing away heat and promoting diuresis.Main heating；Thirsty；Vexed；Dysuria.
Radix rubi buergeri: Ji Yuan: the root of the certain kind of berries of trembling with fear for rosaceous plant.Nature and flavor: bitter；Acid；Cold.Gui Jing: liver；Kidney channel.Function cures mainly: heat clearing away
Removing toxic substances；Promoting blood circulation and stopping pain.Main jaundice due to damp-heat；Puerperal fever；Infantile hyperpyrexia；Menoxenia；Leukorrhagia；Stomachache folic acid；Hemorrhoid swell
Bitterly；Anus fistulae.
Rhizoma disporopsis pernyi: Ji Yuan: for the rhizome of liliaceous plant D. pernyi.Nature and flavor: sweet in the mouth；Property flat.Function cures mainly: QI invigorating
Spleen invigorating；Nourishing YIN and moistening the lung；Relaxing muscles and tendons to promote blood circulation.Main puerperal asthenia；Infantile malnutrition；Cough due to yin deficiency；Hyperhidrosis；Xerostomia；Treating swelling and pain by traumatic injury；Arthritis pain
Bitterly；Lumbago.
Cortex torricelliae tiliifoliae: Ji Yuan: for root bark, the peel of stem blade of Cornaceae plant sheath Tectona grandis L. F..Nature and flavor: acrid in the mouth；Sweet；Property flat.Merit
Can cure mainly: promoting blood circulation and stopping pain；Removing toxic substances and promoting subsidence of swelling.Main traumatic injury stasis of blood pain；The fracture injury of tendon and muscle；Rheumatic arthralgia；Ulcerative carbuncle furuncle and phyma.
Radix Symplocoris Caudatae: Ji Yuan: for the root of Symplocaceae plant mountain vitriol.Nature and flavor: bitter；Pungent；Property flat.Gui Jing: liver, stomach warp.Function master
Control: clearing away heat-damp and promoting diuresis；Cooling blood for hemostasis；Wind-expelling pain-stopping.Main jaundice；Have loose bowels；Dysentery；Metrorrhagia；Acute toothache；Headache；Rheumatic arthralgia.
Folium Linderae strychnifoliae: Ji Yuan: for the leaf of the canella Radix Linderae.Nature and flavor: pungent；Temperature.Gui Jing: spleen；Kidney channel.Function cures mainly: warming middle-JIAO
Regulate the flow of vital energy；Reducing swelling and alleviating pain.Main coldness and pain in the epigastrium；Frequent micturition；Rheumatic arthralgia；Traumatic pain；Scald.
Radix seu Folium pruni simenii: Ji Yuan: for root or the leaf of rosaceous plant Fructus Pruni Lee.Nature and flavor: bitter；Cold；Nontoxic.Gui Jing: the heart；Liver Channel.Merit
Can cure mainly: clearing heat and relieving fidgetness, relieving stranguria by diuresis, hemostasis.Master quenches one's thirst, vexed, nebulousurine, edema, spits blood, metrorrhagia, traumatic injury, and blood stasis is made
Bitterly.
Herba Thalictri Ichangensis: source: for herb or the root of ranunculaceae plant shield leaf Thalictrum aquilegifolium L. var. sibiricum Regel.Chemical analysis: containing boldine dimethyl ether, dehydrogenation
Boldine dimethyl ether, Thalicsimidine, dehydrogenation Thalicsimidine, thaliporphine alkali.Nature and flavor: bitter；Cold.Gui Jing:
Return liver；Stomach；Large intestine channel.Function cures mainly: heat-clearing and toxic substances removing；Dampness.Cure mainly jaundice due to damp-heat；Hygropyretic dysentery；Infantile convulsion；Conjunctival congestion swells
Bitterly；Erysipelas urticaria；Thrush；Traumatic injury.
The clinical practice of the preparation (embodiment 5) of test example 1 gained of the present invention treatment gastric ulcer and duodenal ulcer:
1 data and method
1.1 physical data
Choosing patient's totally 375 example that in March, 2012, my division of gastroenterology of institute of in JIUYUE ,-2014 accepted for medical treatment, wherein male 195 example, women 180
Example, at minimum 21 years old of age, maximum 67 years old, the course of disease was at 3 months-6 years；Wherein patients w ith peptic ulcer disease 217 example, duodenal ulcer patients
158 examples.All patients all make a definite diagnosis through electronic gastroscope or x-ray barium meal examination.
1.2 Therapeutic Method
All patients are randomly divided into experimental group and matched group, and two groups of patients are at aspects such as sex, age, the courses of disease, at statistics
Reason no significant difference (P ＞ 0.05), has comparability.Wherein experimental group takes gained medicine of the present invention, instructions of taking:
Three times a day, each 15-20g, warm water takes after mixing it with water, 7 days courses for the treatment of.Observe altogether and treat three courses for the treatment of.Matched group takes other medicines
Thing (such as medicines such as amoxicillin, omeprazole, motiliums).
1.3 curative effect determinate standard
Curing: after treatment, patient's symptom and sign disappear, ulcer healing, diseased region recovers normal；
Effective: stomachache is alleviated, and other symptoms significantly alleviate, and ulcer area reduces, and diseased region is obviously improved；
Invalid: symptom and sign be improvement or the state of an illness relatively treat before increase the weight of.
Total effective rate=(curing number of cases+effective number of cases)/total inspection case load × 100%.
1.4 therapeutic outcome
Result is as shown in table 1.
Table 1: experimental group and the therapeutic outcome of matched group patient
Therapeutic effect: experimental group cures 144 examples (70.2%), effective 57 examples (27.8%), and invalid 4 examples (2%), total effective rate is
98%；And matched group total effective rate is 79.4%, therefore experimental group therapeutic effect is substantially better than matched group.
The present invention is by the totally 15 taste crude drug such as Herba Polygoni Capitati, the Flos rosae multiflorae, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Smilacis discotis, Haematitum, Radix Codonopsis and Semen Oroxyli
Formulated.Fang Zhong, Flos rosae multiflorae stomach function regulating, hemostasis, removing toxic substances；Rhizoma Smilacis discotis dispels the wind, heat clearing away, dampness removing；Haematitum suppressing the hyperactive liver town is inverse；Radix Codonopsis
Invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung；Semen Oroxyli soothing liver-QI, stomach function regulating；Rhizoma lophantheri clearing away heat and promoting diuresis；Radix rubi buergeri promoting blood circulation and stopping pain；Rhizoma disporopsis pernyi QI invigorating is good for
Spleen, nourishing YIN and moistening the lung；Cortex torricelliae tiliifoliae promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling；Folium Linderae strychnifoliae warming middle-JIAO is regulated the flow of vital energy, reducing swelling and alleviating pain；Radix seu Folium pruni simenii clearing heat and relieving fidgetness, profit
Water is treating stranguria；Herba Thalictri Ichangensis heat-clearing and toxic substances removing, dampness.After treating three months, experimental group total effective rate is up to 98%, and matched group is only
79.4%。
It should be pointed out that, the detailed description of the invention more representational example that is the present invention, it is clear that the skill of the present invention
Art scheme is not limited to above-described embodiment, it is also possible to have many variations.Those of ordinary skill in the art, the most public with present invention institute
What what that open or according to file written description was undoubted obtained, all it is considered as this patent scope of the claimed.
Claims (10)
1. cure gastric ulcer and the preparation of duodenal ulcer, it is characterized in that, take following raw materials according and be prepared from, be weight portion:
Herba Polygoni Capitati 3-6；Flos rosae multiflorae 1-4；Pseudobulbus Bletillae (Rhizoma Bletillae) 7-11；Rhizoma Smilacis discotis 9-11；Haematitum 2-4；Radix Codonopsis 8.5-11.5；Semen Oroxyli 4-6；Broken
Frame 3-7；Radix rubi buergeri 11-14；Rhizoma disporopsis pernyi 6-8；Cortex torricelliae tiliifoliae 5-7；Radix Symplocoris Caudatae 7-13；Folium Linderae strychnifoliae 4-8；Radix seu Folium pruni simenii 1-4；Herba Thalictri Ichangensis
4.5-8.5。
2. treatment gastric ulcer as claimed in claim 1 and the preparation of duodenal ulcer, is characterized in that, take following raw materials according and prepare
Form, be weight portion: Herba Polygoni Capitati 4-5；Flos rosae multiflorae 2-3；Pseudobulbus Bletillae (Rhizoma Bletillae) 8-10；Rhizoma Smilacis discotis 9.5-10.5；Haematitum 2.5-3.5；
Radix Codonopsis 9-11；Semen Oroxyli 4.5-5.5；Rhizoma lophantheri 4-6；Radix rubi buergeri 12-13；Rhizoma disporopsis pernyi 6.5-7.5；Cortex torricelliae tiliifoliae 5.5-6.5；Mountain vitriol
Root 9-11；Folium Linderae strychnifoliae 5-7；Radix seu Folium pruni simenii 2-3；Herba Thalictri Ichangensis 5.5-7.5.
3. treatment gastric ulcer as claimed in claim 1 and the preparation of duodenal ulcer, is characterized in that, take following raw materials according and prepare
Form, be weight portion: Herba Polygoni Capitati 4.5；The Flos rosae multiflorae 2.5；Pseudobulbus Bletillae (Rhizoma Bletillae) 9；Rhizoma Smilacis discotis 10；Haematitum 3；Radix Codonopsis 10；Semen Oroxyli 5；
Rhizoma lophantheri 5；Radix rubi buergeri 12.5；Rhizoma disporopsis pernyi 7；Cortex torricelliae tiliifoliae 6；Radix Symplocoris Caudatae 10；Folium Linderae strychnifoliae 6；Radix seu Folium pruni simenii 2.5；Herba Thalictri Ichangensis 6.5.
4. the preparation method of the preparation granules agent curing gastric ulcer and duodenal ulcer as described in claim 1-3 is arbitrary,
It is characterized in that, step is as follows:
(1) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.25-0.45 times amount of 0.4-0.7 times amount
(preferably adding yellow wine and the rice vinegar of 0.35 times amount of 0.55 times amount), slow fire boiling 10-20 minute (preferably slow fire boiling 15 minutes),
Take out, dry, be ground into fine powder, standby；
(2) Folium Linderae strychnifoliae, the Flos rosae multiflorae and Radix seu Folium pruni simenii being mixed, the Mel adding 0.16-0.30 times amount (preferably adds the honeybee of 0.25 times amount
Honey), mix thoroughly, vexed 6-10 minute (the most vexed 8 minutes), then slow fire add propagandize hotly to tack-free for degree, take out, standby；
(3) crude drug after step (2) being processed together is placed in frying pan with Herba Polygoni Capitati, Semen Oroxyli, Herba Thalictri Ichangensis and Rhizoma disporopsis pernyi, adds
The clear water (preferably adding the clear water of 7 times amount) of 5.5-8.5 times amount, slow fire boiling 40-60 minute (preferably slow fire boiling 50 minutes), mistake
Filter, filtrate reduced in volume to 80 DEG C relative density is the clear paste of 1.22-1.25, standby；
(4) Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Smilacis discotis, Radix Codonopsis, Rhizoma lophantheri, Radix rubi buergeri, Cortex torricelliae tiliifoliae and Radix Symplocoris Caudatae fully be dry, pulverize into fine powder,
Mix with step (1) gained fine powder, sieve, obtain mixing fine powders, standby；
(5) step (4) gained mixing fine powders is joined in step (3) gained clear paste, add other adjuvant while stirring, mixed
Even, make bead dosage form according to the processing method of granule, to obtain final product.
The preparation method of the preparation granules agent for the treatment of gastric ulcer the most according to claim 4 and duodenal ulcer, it is special
Levy and be, step (4) 100-140 mesh sieve excessively (preferred 110-130 mesh sieve, mistake 120 mesh sieve more preferably excessively).
The preparation method of the preparation granules agent for the treatment of gastric ulcer the most according to claim 4 and duodenal ulcer, it is special
Levy and be, step (5) described adjuvant be mass fraction be 4.5% ethyl cellulose and mass fraction be the Polyethylene Glycol of 1.9%.
7. the preparation method of the preparation capsule curing gastric ulcer and duodenal ulcer as described in claim 1-3 is arbitrary,
It is characterized in that, step is as follows:
(1) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.25 times amount, the slow fire boiling of 0.4 times amount
10 minutes, take out, dry, be ground into fine powder, standby；
(2) Folium Linderae strychnifoliae, the Flos rosae multiflorae and Radix seu Folium pruni simenii are mixed, add the Mel of 0.16 times amount, mix thoroughly, vexed 6 minutes, then slow fire heating
Fry and take out for spending to tack-free, dry, be ground into fine powder, standby；
(3) Semen Oroxyli, Cortex torricelliae tiliifoliae, Radix Symplocoris Caudatae and Rhizoma Smilacis discotis are mixed, add the ethanol sealing extraction that concentration is 50%-80% (excellent
Choosing adds the ethanol that concentration is 65% and seals extraction), collect lixiviating solution, reclaim ethanol, through concentrating under reduced pressure, be dried, obtain sepia thin
Powder, standby；
(4) by the crude drug boiling in addition to step (1)-(3) twice, the clear water (preferably the of 8-10 times amount is added for the first time
Once add the clear water of 9 times amount), slow fire boiling 40-50 minute (preferably slow fire boiling 45 minutes), filter, medicinal residues add 3-6 times amount again
Clear water (preferably medicinal residues add the clear water of 4.5 times amount again), slow fire boiling 20-30 minute (preferably slow fire boiling 25 minutes), filter,
Merging twice filtrate, concentrating under reduced pressure becomes thick paste, standby；
(5) step (1)-(3) gained fine powder is joined in above-mentioned thick paste, mixing, it is spray-dried, granulate, loads capsule shells, i.e.
?.
The preparation method of the preparation capsule for the treatment of gastric ulcer the most according to claim 7 and duodenal ulcer, it is special
Levying and be, step (3) extraction time is that (preferred extraction time was 18-22 hour, extraction time more preferably in 15-25 hour
It it is 20 hours).
9. the preparation method of the formulation tablet curing gastric ulcer and duodenal ulcer as described in claim 1-3 is arbitrary, its
Feature is, step is as follows:
(1) Semen Oroxyli, Cortex torricelliae tiliifoliae, Radix Symplocoris Caudatae and Rhizoma Smilacis discotis are mixed, add the ethanol that concentration is 50% and seal extraction 20 hours,
Collect lixiviating solution, reclaim ethanol, through concentrating under reduced pressure, be dried, obtain sepia fine powder, standby；
(2) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.3 times amount, the slow fire boiling of 0.5 times amount
15 minutes, take out, dry, be ground into fine powder, standby；
(3) crude drug in addition to step (1) and (2) is placed in frying pan, adds cold water and do not had powder 3-5cm, soak 3-6 hour
(preferably soaking 4.5 hours), then big fire heated and boiled, turn little fire and decoct 32-48 minute (preferably turning little fire to decoct 40 minutes),
Filtering, filtrate reduced in volume becomes thick paste, is spray-dried the powder that gets dry extract, standby；
(4) by step (1)-(3) process after raw material mixing, add mass fraction be 3% amylum pregelatinisatum and mass fraction be
The magnesium stearate of 1.5%, mixing, cross 70-90 mesh sieve (preferably crossing 80 mesh sieves), make tablet according to the processing mode of tablet, i.e.
?.
10. the preparation method of the preparation water preparation curing gastric ulcer and duodenal ulcer as described in claim 1-3 is arbitrary, its
Feature is, step is as follows:
(1) Haematitum is broken into fritter, is placed in frying pan, add yellow wine and the rice vinegar of 0.3 times amount, the slow fire boiling of 0.5 times amount
15 minutes, take out, dry, be ground into fine powder, cross 140-160 mesh sieve (preferably crossing 150 mesh sieves), standby；
(2) Folium Linderae strychnifoliae, the Flos rosae multiflorae and Radix seu Folium pruni simenii being mixed, add the Mel of 0.25 times amount, mix thoroughly, vexed 10 minutes, then slow fire added
Propagandize hotly and take out for spending to tack-free, standby；
(3) crude drug after step (2) being processed and Herba Polygoni Capitati, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Smilacis discotis, Radix Codonopsis, Semen Oroxyli, Rhizoma lophantheri, the cold certain kind of berries
Root, Rhizoma disporopsis pernyi, Cortex torricelliae tiliifoliae, Radix Symplocoris Caudatae and Herba Thalictri Ichangensis are together placed in frying pan, and the clear water adding 9-11 times amount (preferably adds 10 times amount
Clear water), big fire is heated to boiling, turns little fire and decocts 38-60 minute (preferably turning little fire to decoct 50 minutes), filters, and filtrate decompression is dense
It is reduced to the 1/2 of original volume, standby；
(4) joining in step (3) gained filtrate by step (1) gained fine powder, mixing, sterilizing encapsulates, to obtain final product.
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| Title |
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| 张兆辉: "由消化性溃疡相关文献探讨中医治疗与处方用药规律", 《中国博士学位论文全文数据库(电子期刊)》 * |
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Address after: 810000, building 3, No. 361, Qilian Road, Chengbei District, Qinghai, Xining 1-302 Applicant after: Zhang Guichen Address before: 250000 No. 23, Hualong Road, Licheng District, Shandong, Ji'nan Applicant before: Zhang Guichen |
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