CN105767837B - A kind of coolant compositions, the essence containing coolant compositions and its application - Google Patents
A kind of coolant compositions, the essence containing coolant compositions and its application Download PDFInfo
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- CN105767837B CN105767837B CN201610118403.5A CN201610118403A CN105767837B CN 105767837 B CN105767837 B CN 105767837B CN 201610118403 A CN201610118403 A CN 201610118403A CN 105767837 B CN105767837 B CN 105767837B
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- coolant compositions
- oil
- essence
- freshener
- polyglutamic acid
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/56—Flavouring or bittering agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Confectionery (AREA)
Abstract
The invention discloses a kind of coolant compositions, the essence containing coolant compositions and its applications.The coolant compositions are made of polyglutamic acid and freshener；1,000,000 dalton of molecular weight ＞ of the polyglutamic acid, the freshener are oil-soluble.The coolant compositions can be used in such as candy, cake, beverage food, it may also be used in such as toothpaste, mouthwash oral care implement, it may also be used in the daily necessities such as cosmetics, shampoo.Coolant compositions of the present invention are longer in skin and the retention time in oral cavity, and even if additive amount is larger, will not generate bitter sense or other pessimal stimulations.
Description
Technical field
The present invention provides a kind of composition, and in particular to a kind of coolant compositions, the essence containing coolant compositions
And its application.The composition can generate full, balanced, lasting cool feeling in the oral cavity of human body and throat.The composition can transport
In the food such as such as candy, cake, beverage, it may also be used in such as toothpaste, mouthwash oral care implement, it may also be used for change
In the daily necessities such as cosmetic, shampoo.
Background technology
Traditionally, toothpaste, candy, beverage, tobacco, poultice, cosmetics etc. are used for, to the skin of people, oral cavity, throat with
The nice and cool freshener felt with cold refreshing feeling：L-menthol is widely used, but l-menthol has the holding in cooling effect
Not lasting enough defect in ability, and if when increasing dosage, strengthening cooling effect, but consequently also with unfavorable bitter sense.
In order to make up the simple shortcoming for using l-menthol, many effort have been done to synthesize other various refrigerantization
Close the composition of object and the various cooling compounds of research.
Menthol derivative and the freshener containing menthol derivative component are disclosed in publication number CN1950057A
Composition.Ketal compound and menthol involved in application number 93106070, the composition of contracting amide.German patent application
2339661 disclose aromatic composition, include the menthol esters of menthol or different ring carboxylic acids.Japanese Patent Application Laid-Open
N- substitutions-p- terpane -3- Carboxylamides involved in No. No.47-16648.Japanese Patent Application Laid-Open No.61-194049
Involved in 1- menthyl -3- hydroxybutyl compounds.
German patent application the 2608226th discloses a kind of composition, shows a kind of cooling effect physiologically.
Acetic acid menthol ester and menthyl lactate are cooling compounds best in the announcement.In publication number
The freshener combination formed containing ketal and menthol, one kind of carbonyl amide or their mixture involved in CN1084387A
Object.In a kind of coolant compositions involved in publication number CN1179094A, this kind of composition includes a kind of suitable carrier, one kind
The composition of dihydric alcohol and freshener composition.One kind is provided in application publication number CN 102558036A by N-Ethyl-p-menthane-3-carboxamide type
Derivative and N- ethyl -2- isopropyl -5- methyl-cyclohexyl alkane amides compound and the coolant compositions of acquisition.In Granted publication
A kind of coolant compositions for candy involved in number 101119643 B of CN, the composition is by menthol and at least one
The physiological cooling agents of p- menthane carbosamided, acyclic carboxamides, menthyl succinate selected from N- substitutions and combinations thereof merge.
Above-mentioned single freshener has a degree of cooling effect, but does not still make us full in terms of the persistence of cooling effect
Meaning.
Existing coolant compositions, although improving the persistence of cooling effect, duration to a certain extent
It is still unsatisfactory, and existing coolant compositions are higher in cost, are unfavorable for application.The reason of leading to problem above
It is：On the one hand, existing freshener is insufficient in terms of the persistence of cooling effect；On the other hand, the freshener being used in oral cavity
With the flowing of saliva, residual quantity in the oral cavity can be slowly reduced, is weakened so as to cause cooling effect enduring quality.
Invention content
It is an object of the invention to overcome the defect of the above-mentioned prior art, a kind of novel coolant compositions are provided, it should
Composition has the sustainability of excellent nice and cool or cold refreshing feeling, and will not bring undesirable stimulation, especially
Stink and bitter taste.
To achieve the purpose of the present invention, technical scheme is as follows：
Novel freshener composition of the present invention is made of polyglutamic acid and freshener, the molecule of the polyglutamic acid
1,000,000 dalton of ＞ is measured, the freshener is oil-soluble, preferably ten thousand dalton of 120-150.
The application polyglutamic acid effect principle be：Macromolecular polyglutamic acid can be formed similar to porous as agar
Property membrane structure, adsorb freshener, membrane structure can be adsorbed on hair or oral cavity epidermis, and the release time of freshener is extended.
In cosmetic field, polyglutamic acid is made into water-retaining agent, can generally select the ingredient of small molecule, is more convenient for absorbing in this way.
Wherein the accounting of polyglutamic acid in the composition is 50-98%wt, is most preferably accounted for as 80-95%wt.
The application has found that oil-soluble freshener can be used in compounding with polyglutamic acid, improves its persistence.Especially
By polyglutamic acid, N- ethyl-L- menthyls formamides (hereinafter referred to as WS-3) and N- (ethoxycarbonylmethyl group)-to alkane -3- formyls
When amine (hereinafter referred to as WS-5) three compounds, refrigerant sense duration is at most.
Wherein the accounting of polyglutamic acid in the composition is 50-98%, is most preferably accounted for as 80-95%, remaining is N- ethyls-L-
Menthyl formamide and N- (ethoxycarbonylmethyl group)-are to alkane -3- formamides；
Wherein, N- ethyls-L- menthyls formamide and N- (ethoxycarbonylmethyl group)-are to the mass ratio of alkane -3- formamides
It is 0.5:1~5:1, optimal proportion 1:1~3:1；
Polyglutamic acid according to the present invention is using boiomacromolecule, molecular weight ＞ 100 made from microbe fermentation method
Ten thousand dalton, preferably ten thousand dalton of 120-150；With excellent water-soluble, superpower adsorptivity and biodegradability, degradation
Product is non-harmful glutamic acid, is a kind of excellent environment-friendly type macromolecule material.
WS-3 according to the present invention comes from Millennium company of the U.S., is a kind of several subdiaphanous white crystals, main to use
Cool dose of system in such as medicine, oral care, candy.It can generate more impacting, pure and fresh, lasting fragrance, its mouth
Sense threshold values is 200ppb (be put into mouth and measured with Tetefol item).
WS-5 according to the present invention come from Millennium company of the U.S., a kind of white crystal, be mainly used for as oral care,
Cool dose of system in candy has the cool feeling more more longlasting than l-menthol
Novel freshener composition of the present invention is by polyglutamic acid, N- ethyl-L- menthyls formamide, N- (ethoxies
Carbonvlmethyl)-alkane -3- formamide threes are compounded.The refrigerant sense persistence of the coolant compositions of the present invention is good, is better than
Existing freshener.
The present invention also provides a kind of essence containing the coolant compositions, and the coolant compositions are in perfume (or spice)
Content in essence is 0.001~40%wt.It is preferred that content of the coolant compositions in essence is 0.1~30%wt.
The essence further includes one or more of essential oil, fragrance or perfume preservative.
The essential oil includes but not limited to mentha piperita oil, spearmint oil, asia peppermint oil, lemon oil, orange oil, fennel
One or more of oil, trans-anethole or wintergreen；The fragrance include but not limited to phenylethyl alcohol, methyl phenyl carbinyl acetate,
One or more of eugenol, rose oxide, linalool, muskone or benzaldehyde；The perfume preservative includes but not limited to
Propylene glycol, glycerine, butanediol, hexylene glycol, triethyl citrate, diethyl phthalate, MCT Oil
One or more of.
The present invention also provides the essence in beverage, candy, cosmetics, oral care implement, showering agent or drug
Application.
In addition, the present invention also provides the beverage of the coolant compositions, candy, cosmetics, oral care implement, washing
Bathe the application in agent or drug.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) since the polyglutamic acid of macromolecular has good absorption property, freshener ingredient can be helped in skin, oral cavity
The residual at the positions such as mucous membrane, while porous structure can adsorb freshener, promote the gradually release of freshener.
(2) present invention is had found by test of many times, and WS-3 and WS-5 has good associativity with polyglutamic acid, compares other
Freshener, both fresheners are longer in skin and the retention time in oral cavity.
(3) polyglutamic acid, WS-3 and WS-5 are compounded by certain ratio, have good cooling effect, and this three has
There is synergy, is significantly improved with the cooling effect that polyglutamic acid is used in compounding than a kind of individually freshener.
(4) even if coolant compositions additive amount according to the present invention is larger, bitter sense will not be generated or other are bad
Stimulation, this is also the big advantage of the present invention.
Specific implementation mode
The present invention is described in further details below by specific embodiment.
Embodiment 1
The embodiment of coolant compositions：(unit is mass percent)
| Ingredient | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Polyglutamic acid | 85 | 90 | 90 |
| WS-3 | 10 | 7.5 | 5 |
| WS-5 | 5 | 2.5 | 5 |
【The preparation method of coolant compositions】：
WS-3 and WS-5 is dissolved by heating；
Polyglutamic acid is added, stirs 5min
Mixture is cooled to room temperature in ice bath to get.
【The sensory evaluation of embodiment】
The coolant compositions of embodiment 1,2,3 and the cooling perception lasts of l-menthol are commented by oral cavity evaluation
Valence.Evaluation method is as follows：
This evaluation test is random, double blind, control, parallel sensory evaluation test；
This evaluation is completed using the sensory evaluation group of profession, and the sensory evaluation group is by by training and passing through examination
7 people composition, there is sharp sense organ, objectively the refrigerant sense of product can be evaluated, give a mark.
A concentration of 20ppm is prepared, the aqueous solution 1000ml containing coolant compositions and l-menthol obtained by each.
The member of sensory evaluation group is containing gargling 10ml each solution 15 seconds, discharge solution, evaluates at that moment refrigerant
Sense, is defined as 0min that times, later respectively in 5min, 15min, 25min, 35min, 45min, 60min, 75min, 90min
It scores refrigerant sense.Scoring score value is 10 score values, and 0=refrigerant senses disappear, and 10=is very strong.
Dduring test, evaluation personnel cannot drink water and feed；
【Embodiment Analyses Methods for Sensory Evaluation Results】
Test result is as follows for refrigerant sense shown in table：
7 bit test personnel all evaluate compounding coolant compositions have excellent refrigerant sense, embodiment 1, embodiment 2,
The cooling perception lasts degree of embodiment 3 is significantly higher than l-menthol.The freshener persistence of compounding can reach 1 hour or more, and general
The refrigerant persistence of logical freshener l-menthol only has 15min effects.
Embodiment 4
【The sensory evaluation of embodiment】
By oral cavity evaluation to coolant compositions, polyglutamic acid and the WS-5 (mass ratio 17 of embodiment 1:2) it compounds, is poly-
Glutamic acid and WS-3 (mass ratioes 17:1) cooling perception lasts of compounding, WS-5 and WS-3 are evaluated.Evaluation method is as follows：
This evaluation test is random, double blind, control, parallel sensory evaluation test；
This evaluation is completed using the sensory evaluation group of profession, and the sensory evaluation group is by by training and passing through examination
7 people composition, there is sharp sense organ, objectively the refrigerant sense of product can be evaluated, give a mark.
A concentration of 20ppm is prepared, the aqueous solution 1000ml containing the coolant compositions obtained by each.
The member of sensory evaluation group is containing gargling 10ml each solution 15 seconds, discharge solution, evaluates at that moment refrigerant
Sense, is defined as 0min that times, later respectively in 5min, 15min, 25min, 35min, 45min, 60min, 75min, 90min
It scores refrigerant sense.Scoring score value is 10 score values, and 0=refrigerant senses disappear, and 10=is very strong.
Dduring test, evaluation personnel cannot drink water and feed；
【Embodiment Analyses Methods for Sensory Evaluation Results】
Test result is as follows for refrigerant sense shown in table：
The coolant compositions that 7 bit test personnel evaluate compounding have excellent refrigerant sense, can be obtained by upper table,
For WS-5 with after polyglutamic acid compounding, effect is better than single WS-5；It can be seen that the addition of polyglutamic acid extends the lasting of refrigerant sense
Property, especially when polyglutamic acid, WS-3 and WS-5 threes compounding, the refrigerant sense persistence of (embodiment 1) is significantly higher than polyglutamic
Acid is compounded with WS-3 compoundings and polyglutamic acid with WS-5, can prove that WS-3 and WS-5 has synergistic effect.
In the present invention, the coolant compositions of compounding can be added directly into various products such as essence, beverage and candy, change
In cosmetic, oral care implement, showering agent and drug.Further, the coolant compositions of compounding can be charged first to perfume (or spice)
In feed composition, to obtain the essence containing coolant compositions, then the essence comprising coolant compositions can be added to
In product.
Include the fragrance of various synthesis, natural essence with the component of essence is configured to together with the coolant compositions of the present invention
Oil, synthesis essential oil, animal perfume material etc..Such as in oral care implement essence widely used mentha piperita oil, spearmint oil,
Asia peppermint oil, lemon oil, orange oil, fennel oil, trans-anethole, wintergreen；Such as it is widely used in cosmetic product essence
Phenylethyl alcohol, methyl phenyl carbinyl acetate, eugenol, rose oxide, linalool, benzaldehyde, muskone etc..It can also be into one
Step includes the perfume preservative of one or more being often used in essence.The example of perfume preservative includes propylene glycol, third
Triol, butanediol, hexylene glycol, triethyl citrate, diethyl phthalate, MCT Oil etc..
In the essence containing coolant compositions, the content of coolant compositions can be adjusted suitably, this depends on essence
Use scope and its other components type.Usually, coolant compositions relative to entire essence combination content with
Quality is calculated as 0.001-40%, preferably in mass 0.1-30%, particularly preferably in mass 1%-20%.
The coolant compositions of the present invention can be separately as freshener, or with the essence containing coolant compositions
Form is added in various products, brings consumer with refrigerant feeling.These products have beverage, candy, cosmetics, oral cavity
Nursing materials, showering agent, drug etc..
The coolant compositions or essence comprising these coolant compositions of the present invention give refrigerant sense candy and
The concrete instance of beverage, is not specially limited in this, including beverage, such as：Fruit drink, milk beverage, soda, movement drink
Material, drinks；Candy, such as：Chewing gum, peppermint candy, pressed candy, chocolate etc..
The coolant compositions of the present invention or the essence comprising these coolant compositions give the cosmetics of refrigerant sense
Or the concrete instance of articles for daily use, including it is fragrance product, Basic skin care products, cosmetic hair, soap, bath foam, clear
Lotion, deodorization and aromatic, pest repellant, toothpaste, mouthwash, tooth powder, mouth washes etc..
According to the effect for the refrigerant sense having needed for product, the freshener for being included in or being supplied to product can be suitably adjusted
The amount of composition, to provide the product cooling sensation.In general, the amount of addition or the offer of coolant compositions, relative to product
Quality, preferably in mass be 0.01-5%, more preferably in mass be 0.1-2%.
Embodiment 4
Oral care implement essence containing coolant compositions
With conventional method, oral care implement essence is produced by formula as below, formula ratio is with quality in formula
Part meter.<Composition>
| Component | Formula ratio |
| Mentha piperita oil | 25 |
| 65% spearmint oil | 17.5 |
| Trans-anethole | 10 |
| 80% eucalyptus oil | 6.5 |
| Thymol | 1 |
| L- menthols | 30 |
| 1 coolant compositions of embodiment | 10 |
Embodiment 5
Toothpaste containing coolant compositions
According to formula below, toothpaste is prepared by the way that 1% coolant compositions of embodiment 2 are added.The toothpaste has
Refrigerant sense, and the persistence of refrigerant sense can keep 30min.
<Formulation of tooth-paste>
Shampoo of the embodiment 6 containing coolant compositions
According to formula as below, shampoo is prepared by the way that 0.8% coolant compositions of implementation 3 are added, which has clear
Cool feeling, and refrigerant sense persistence is good.
<Shampoo formula>
According to the disclosure and teachings of the above specification, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and is changed.Therefore, the invention is not limited in specific implementation modes disclosed and described above, to the present invention's
Some modifications and changes should also be as falling into the scope of the claims of the present invention.In addition, although being used in this specification
Some specific terms, these terms are merely for convenience of description, does not limit the present invention in any way.
Claims (10)
1. a kind of coolant compositions, which is characterized in that be made of polyglutamic acid and freshener；The molecular weight of the polyglutamic acid
1,000,000 dalton of ＞, the freshener are oil-soluble.
2. coolant compositions according to claim 1, which is characterized in that the weight percent of the polyglutamic acid is
50-98%.
3. coolant compositions according to claim 1 or 2, which is characterized in that the freshener is N- ethyl-L- peppermints
Base formamide and N- (ethoxycarbonylmethyl group)-compound both alkane -3- formamides.
4. coolant compositions according to claim 3, which is characterized in that the N- ethyls-L- menthyls formamide with
N- (ethoxycarbonylmethyl group)-is 0.5 to the mass ratio of alkane -3- formamides:1~5:1.
5. a kind of essence containing the coolant compositions described in one of claim 1-4, which is characterized in that the freshener
Content of the composition in essence is 0.001~40%wt.
6. essence according to claim 5, which is characterized in that content of the coolant compositions in essence is 0.1
~30%wt.
7. essence according to claim 5 or 6, which is characterized in that further include one in essential oil, fragrance or perfume preservative
Kind or more.
8. essence according to claim 7, which is characterized in that the essential oil is that mentha piperita oil, spearmint oil, Asia are thin
One or more of lotus oil, lemon oil, orange oil, fennel oil, trans-anethole or wintergreen；The fragrance is phenylethyl alcohol, acetic acid
One or more of methylbenzene base ester, eugenol, rose oxide, linalool, muskone or benzaldehyde；The perfume preservative
For propylene glycol, glycerine, butanediol, hexylene glycol, triethyl citrate, diethyl phthalate, medium chain fatty acid three
One or more of ester.
9. one of the claim 5-8 essence is in beverage, candy, cosmetics, oral care implement, showering agent or drug
Using.
10. beverage, candy, cosmetics, oral care implement, the showering agent of one of the claim 1-4 coolant compositions
Or the application in drug.
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| CN201610118403.5A CN105767837B (en) | 2016-03-02 | 2016-03-02 | A kind of coolant compositions, the essence containing coolant compositions and its application |
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| CN107028779B (en) * | 2017-03-13 | 2021-02-19 | 广州舒客实业有限公司 | Toothpaste containing algefacient composition |
| CN106974845B (en) * | 2017-03-21 | 2021-02-23 | 广州满庭芳实业有限公司 | Essence composition and preparation method and application thereof |
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| JP2005029513A (en) * | 2003-07-07 | 2005-02-03 | Kobayashi Pharmaceut Co Ltd | Breath cool-refreshing preparation and method for producing the same |
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| EP1835815B1 (en) * | 2004-12-29 | 2013-08-28 | Wm. Wrigley Jr. Company | Combinations of cooling agents for use in confections |
| WO2014054737A1 (en) * | 2012-10-05 | 2014-04-10 | 小川香料株式会社 | Powdery refreshing composition |
| CN105079798A (en) * | 2015-09-15 | 2015-11-25 | 孟庆蕾 | Pharmaceutical composition for treating syndrome of retention of lung phlegm-heat in infants and preparation method of pharmaceutical composition |
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|---|---|---|---|---|
| CN1275887A (en) * | 1997-09-18 | 2000-12-06 | Wm.雷格利Jr.公司 | Chewing gum containing physiological cooling agents |
| JP2005029513A (en) * | 2003-07-07 | 2005-02-03 | Kobayashi Pharmaceut Co Ltd | Breath cool-refreshing preparation and method for producing the same |
| EP1835815B1 (en) * | 2004-12-29 | 2013-08-28 | Wm. Wrigley Jr. Company | Combinations of cooling agents for use in confections |
| CN101238203A (en) * | 2005-06-21 | 2008-08-06 | 高砂香料工业株式会社 | Flavor and fragrance composition |
| WO2014054737A1 (en) * | 2012-10-05 | 2014-04-10 | 小川香料株式会社 | Powdery refreshing composition |
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Effective date of registration: 20180903 Address after: 510900 -26, No. 339 Heng Jiang Road, Conghua suburb street, Guangzhou, Guangdong (first to four floors of C building) Applicant after: Guangzhou Mantingfang Industry Co. Ltd. Address before: 510130 Guangdong province Guangzhou city Liwan District Sha noodles North Street 103 Applicant before: GUANGZHOU MANTINGFANG FRAGRANCES CO., LTD. |
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