CN104800299A - Processing method of giant knotweed rhizome - Google Patents
Processing method of giant knotweed rhizome Download PDFInfo
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- CN104800299A CN104800299A CN201510166885.7A CN201510166885A CN104800299A CN 104800299 A CN104800299 A CN 104800299A CN 201510166885 A CN201510166885 A CN 201510166885A CN 104800299 A CN104800299 A CN 104800299A
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Abstract
A processing method of giant knotweed rhizome comprises steps as follows: a medicinal material giant knotweed rhizome is immersed in a pretreatment mixed solution of cellulose and beta-glucosidase and processed under different power in a microwave oven, and a microwave processed product of giant knotweed rhizome is obtained; a preparation method of the pretreatment mixed solution is as follows: cellulose and beta-glucosidase are weighed respectively and dissolved with distilled water, and the pretreatment mixed solution is obtained; the weight ratio of cellulose to beta-glucosidase is (1:5)-(5:1). According to the provided processing method of giant knotweed rhizome, content of two effective ingredients of resveratrol and rheum emodin can be remarkably increased simultaneously, the content of polydatin is reduced, and conversion between polydatin and resveratrol in giant knotweed rhizome is accelerated effectively; compared with a conventional processing technology of giant knotweed rhizome, the processing method has no special requirements for temperature, environment and the like, the production conditions are easy to control, the product quality controllability is good, and an effective way applicable to industrial production is provided for application of giant knotweed rhizome, and the processing method has important practical value.
Description
Technical field
The present invention relates to Chinese medicine processing field, particularly relate to a kind of concocting method of Rhizoma Polygoni Cuspidati.
Background technology
Polygonum cuspidatum Sieb. et Zucc is the dry root welding technology of polygonaceae plant Rhizoma Polygoni Cuspidati (Polygonum cuspidatum Sieb. et Zucc.), mainly originate in the ground such as Jiangxi, Sichuan, Jiangsu, Shandong, its cold nature, mildly bitter flavor, return liver, gallbladder, lung meridian, there is effect of heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing, dampness removing jaundice eliminating, eliminating stasis to stop pain.Main in Rhizoma Polygoni Cuspidati based on sequestered, have the compositions such as emodin, physcione, chrysophanol containing the Multiple components such as anthraquinone, diphenylethylene compounds, wherein anthraquinone derivatives, have antibacterial, protect the liver, rush down under, the function such as anticancer; And diphenylethylene compounds mainly comprises resveratrol and polygonin (polydatin), there is antitumor, blood fat reducing, anticoagulant, adjustment lipoprotein metabolism, protect the liver, antioxidation, the multiple pharmacological effect such as antibacterial.Rhizoma Polygoni Cuspidati enriches because of its medicine source, has pharmacologically active widely, has therapeutical effect, and receive much concern to the multiple systemic disease of human body.At present, be used for the treatment of the polygonin injection of cardiovascular disease, its main component polygonin is the monomer effective ingredient extracted from Rhizoma Polygoni Cuspidati.But be at present all be single index with resveratrol or polygonin mostly to the technique of mentioning of Rhizoma Polygoni Cuspidati, if find a kind of processing procedure to improve and extract two kinds of even two or more effective ingredient simultaneously, will must utilize to Rhizoma Polygoni Cuspidati and bring larger economic benefit and social benefit.
The object of Chinese medicine processing is that process by concocting is to reach the object of attenuation or potentiation.Chinese crude drug there occurs complicated chemical change after Processing methods, thus causes the change of nature and flavor before and after Chinese medicine processing, function and activity.The supplement to Thousand Golden Prescriptions that concocting method about Rhizoma Polygoni Cuspidati begins to be loaded in Tang Sun Simiao work is said: " brain of decaptitating, washes away soil, hot-tempered cut ".The Lei Gong's Treatise on Preparation and Broiling of Materia Medica that Northern and Southern Dynasties Liu Song epoch thunder Xiao writes is said: " after Fan Cai get, thin Shaved, but wraps up in a night with Folium Polygoni Cuspidati, go out to dry use ".Song dynasty is except continuing to use “ Xi Shaved " concocting method except, still have the method such as " for end ", " burning "." thin Shaved ", " Shaved " is mentioned in the Holy Benevolent Prescriptions of compiling such as hidden in Song Wang Huai." rebuilding is had stable political situation through history card class book on Chinese herbal medicine for subsequent use " is said: " get root wash away chapped Pi ， Shaved roasting smash sieve ", " for end "." Shengji Zonglu " is said: " burning ".Song's Holy Benevolent Prescriptions: " unsmooth menorrhea.Rhizoma Polygoni Cuspidati three liang, Myrrha one or two is end, and hot wine often takes a money ".The Ming Dynasty still continues to use the experience of forefathers, and " Prescriptions for Universal Relief " that Ming Zhu Su etc. compile records " burning ".Compendium of Material Medica is said: " adopt to obtain ， Xi Shaved, but with leaf bag one night, dry use "." control postnatal blood stasis blood pain, and pendant is flutterred confused vexed: polygoni cuspidati,radix, grind wine clothes into powder "." pandect processed by big gun " also records: " polygoni cuspidati,radix goes epithelium to use ".The clear concocting method not having document to record Rhizoma Polygoni Cuspidati.To modern, Rhizoma Polygoni Cuspidati records kind as Chinese Pharmacopoeia, has all clearly defined from 5 editions pharmacopeia since version in 1985 under Rhizoma Polygoni Cuspidati concocts item.Within 2010, version " pharmacopeia ", " national Chinese medicine processing specification " are all recorded: " removing impurity, cleans, run through, cut sheet, dry ".As can be seen here, the concocting method of Rhizoma Polygoni Cuspidati, successive dynasties medical literature is recorded only has processed with wine, vinegar system, salt etc., and China is also weaker for Rhizoma Polygoni Cuspidati process of preparing Chinese medicine research at present, the curative effect of existing concocting method is also not clear and definite, particularly lack the comparative study of material base change and pharmacological effect activity before and after concocting, only have the concocting method that can improve Rhizoma Polygoni Cuspidati drug effect just to there is actual application value.Therefore, need a kind of efficient, cheap, environmental protection of exploitation badly, improve the Rhizoma Polygoni Cuspidati concocting method of two or more effective ingredient, to meet the needs of people simultaneously.
Summary of the invention
For the problems referred to above, significantly increase the Rhizoma Polygoni Cuspidati concocting method of resveratrol and emodin two kinds of active constituent contents while of the invention provides a kind of, the method is with cellulase, beta-glucosidase for adjuvant, and concocting process is easy, easily standardization and popularization.
For realizing above-mentioned purpose of the present invention, the invention provides a kind of concocting method of Rhizoma Polygoni Cuspidati, step is: be immersed in by Rhizoma Polygoni Cuspidati after soaking in the pretreatment mixed solution of cellulase, beta-glucosidase, puts in microwave oven and concocts under different capacity, obtain Rhizoma Polygoni Cuspidati microwave processing product.
The weight proportion of described cellulase, beta-glucosidase is 1:5-5:1.
The preparation method of described pretreatment mixed solution is: take cellulase respectively, beta-glucosidase adding distil water dissolves and get final product.
The consumption summation of described cellulase and beta-glucosidase is the 0.1-10 ‰ of Rhizoma Polygoni Cuspidati consumption, and soak time is 2-12h.
Concocting power used in described microwave oven is 40%-100% power, and the time used is 10min-30min.
Described Rhizoma Polygoni Cuspidati can from Different sources.
Compared with prior art beneficial effect of the present invention.
Rhizoma Polygoni Cuspidati concocting method provided by the invention, with cellulase, beta-glucosidase for adjuvant, through microwave treatment and get final product; This concocting method significantly can increase the content of resveratrol and emodin two kinds of effective ingredient simultaneously, and the content of polydatin reduces, and effectively facilitates between Resveratrol in Rhizoma Polygoni Cuspidati glycosides and resveratrol and must transform; Compared with Rhizoma Polygoni Cuspidati tradition processing procedure, this concocting method does not have particular/special requirement to temperature, environment etc., and medical material microwave energy absorbing in microwave heating process, in certain temperature range, the inner main component of medical material is activated or concluding state weakens, thus the change on medical material interior molecules recurring structure, the content of main component is changed.The method can make full use of resource, concocting process is easy, production cost is low, and whole concocting process is sent without organic pollution, environmental pollution is very little, and working condition is easy to manipulation, and product quality controllability is good, application for Rhizoma Polygoni Cuspidati provides the effective way that adapts to suitability for industrialized production, has important actual application value.
Accompanying drawing explanation
Fig. 1 is the content (mgg recording polygonin, resveratrol and emodin in Rhizoma Polygoni Cuspidati processed product under different process of preparing Chinese medicine factor of influence
-1).
Detailed description of the invention
The present invention is further described below in conjunction with specific embodiment.
Embodiment 1.
The invention provides a kind of concocting method of Rhizoma Polygoni Cuspidati, step is: be immersed in by 15g Rhizoma Polygoni Cuspidati in the pretreatment mixed solution of 20ml cellulase, beta-glucosidase, after soaking 10h, put in microwave oven and concoct 25min under 40% power, obtain Rhizoma Polygoni Cuspidati microwave processing product.
The weight proportion of described cellulase, beta-glucosidase is 1:2.
The preparation method of described pretreatment mixed solution is: take cellulase 5mg respectively, beta-glucosidase 10mg adds 30ml distilled water and dissolve and get final product, get the Pretreatment Mixed Liauid 20ml prepared and concoct for above-mentioned Rhizoma Polygoni Cuspidati.
For verifying the beneficial effect of Rhizoma Polygoni Cuspidati concocting method of the present invention further, carry out following experiment.
1, different investigation of concocting factor of influence.
1.1, method: (1) cellulose enzyme process: get Rhizoma Polygoni Cuspidati 15g, is immersed in 20ml cellulase solution, after soaking 10h, puts in microwave oven and concoct 25min under 40% power; Described cellulase solution adds 30mL distilled water by 5mg cellulase to dissolve obtained; (2) beta-glucosidase enzyme process: get Rhizoma Polygoni Cuspidati 15g, is immersed in 20ml beta-glucosidase enzymatic solution, after soaking 10h, puts in microwave oven and concoct 25min under 40% power; Described beta-glucosidase enzymatic solution adds 30mL distilled water by 10mg beta-glucosidase to dissolve obtained; (3) two enzyme oven drying method: get Rhizoma Polygoni Cuspidati 15g, is immersed in 20ml cellulase, beta-glucosidase mixed solution, after soaking 10h, after solution is sucked, puts into 40 DEG C of baking ovens, dries to constant mass; Described mixed solution adds 30mL distilled water by 5mg cellulase, 10mg beta-glucosidase to dissolve obtained; (4) concocting method (being called for short two enzyme microwave method) of the present embodiment 1.
1.2, result, refers to Fig. 1, and Fig. 1 is the content (mgg recording polygonin, resveratrol and emodin in Rhizoma Polygoni Cuspidati processed product under different process of preparing Chinese medicine factor of influence
-1).
As shown in Figure 1, Rhizoma Polygoni Cuspidati adopts cellulose enzyme process, beta-glucosidase enzyme process, two enzyme oven drying method and two enzyme microwave method to concoct, gained processed product is compared with the Rhizoma Polygoni Cuspidati without any process, its resveratrol and emodin content all increase, and the content of polygonin all decreases.But resveratrol and emodin content improve the most remarkable in the Rhizoma Polygoni Cuspidati processed product of two enzyme microwave method, the content of polygonin reduces also the most remarkable, as can be seen here, Rhizoma Polygoni Cuspidati concocting method provided by the invention, significantly can increase the content of resveratrol and emodin two kinds of effective ingredient simultaneously, and the content of polygonin reduces, effectively facilitate between Resveratrol in Rhizoma Polygoni Cuspidati glycosides and resveratrol and must transform; This is mainly due to Rhizoma Polygoni Cuspidati microwave energy absorbing in microwave heating process, in certain temperature range, the inner main component of medical material is activated or concluding state weakens, thus the change on medical material interior molecules recurring structure, the content of main component is changed.
2, the investigation of the different concocting method of Different sources Rhizoma Polygoni Cuspidati.
2.1, the different concocting methods of Different sources Rhizoma Polygoni Cuspidati.(1) processed with wine: get Rhizoma Polygoni Cuspidati (Hubei, Sichuan, Anhui) each 5 g, adds yellow wine 4 mL and mixes thoroughly, moistening, after wine is sucked, puts into 40 DEG C of baking ovens, dries (to constant mass); (2) vinegar system: get Rhizoma Polygoni Cuspidati (Hubei, Sichuan, Anhui) each 5 g, mix thoroughly, moistening with rice vinegar 4 mL, after rice vinegar is sucked, puts into 40 DEG C of baking ovens, dries; (3) salt system: get Rhizoma Polygoni Cuspidati (Hubei, Sichuan, Anhui) each 5 g, add saline 4 mL and mix thoroughly, moistening, treats that saline is sucked, and puts into 40 DEG C of baking ovens, dries (note: every 100g Chinese medicine adds 2g salt); (4) concocting method (being called for short two enzyme microwave method) of the present embodiment 1.
2.2, result refers to table 1, and table 1 is the content (mgg that different concocting method records polygonin, resveratrol and emodin in Different sources Rhizoma Polygoni Cuspidati processed product
-1) (n=3).
Table 1: different concocting method records constituent content in Different sources Rhizoma Polygoni Cuspidati processed product.
| The place of production | Concocting method | Polygonin | Resveratrol | Emodin |
| Hubei | Processed with wine | 15.514 | 5.808 | 6.774 |
| Hubei | Vinegar system | 16.708 | 5.251 | 6.629 |
| Hubei | Salt system | 17.402 | 4.720 | 6.194 |
| Hubei | Two enzyme microwave method | 13.337 | 7.784 | 8.267 |
| Sichuan | Processed with wine | 10.719 | 5.753 | 6.550 |
| Sichuan | Vinegar system | 11.304 | 3.753 | 3.679 |
| Sichuan | Salt system | 12.632 | 2.293 | 2.658 |
| Sichuan | Two enzyme microwave method | 9.240 | 6.687 | 8.861 |
| Anhui | Processed with wine | 12.802 | 5.289 | 5.296 |
| Anhui | Vinegar system | 13.937 | 5.031 | 4.849 |
| Anhui | Salt system | 14.802 | 4.214 | 4.085 |
| Anhui | Two enzyme microwave method | 11.074 | 6.552 | 6.963 |
As shown in Table 1, to the Rhizoma Polygoni Cuspidati of Different sources, in two enzyme microwave method, resveratrol and emodin content improve the most remarkable, and the content of polygonin reduces also the most remarkable, shows that the concocting method of Rhizoma Polygoni Cuspidati of the present invention does not limit by the medical material place of production.In addition, the Rhizoma Polygoni Cuspidati of Different sources, after concocting, its effect is: two enzyme microwave method > processed with wine > vinegar > salt system.This is mainly because Rhizoma Polygoni Cuspidati is in two enzyme microwave method, enzymolysis facilitates the conversion of polygonin to resveratrol, and microwave energy absorbing in microwave heating process, in certain temperature range, the inner main component of medical material is activated or concluding state weakens, thus the change on medical material interior molecules recurring structure, the content of main component is changed; Though processed with wine vinegar system can promote the conversion of glycosides to a certain extent, its effect does not have enzyme process effective, and salt system is then more weak to the conversion of glycosides.
Embodiment 2.
The invention provides a kind of concocting method of Rhizoma Polygoni Cuspidati, step is: be immersed in by 6g Rhizoma Polygoni Cuspidati in the pretreatment mixed solution of 10ml cellulase, beta-glucosidase, after soaking 2h, put in microwave oven and concoct 10min under 80% power, obtain Rhizoma Polygoni Cuspidati microwave processing product.
The weight proportion of described cellulase, beta-glucosidase is 3:1.
The preparation method of described pretreatment mixed solution is: take cellulase 3mg respectively, beta-glucosidase 1mg adds 10ml distilled water and dissolve and get final product, get the Pretreatment Mixed Liauid 10ml prepared and concoct for above-mentioned Rhizoma Polygoni Cuspidati.
Embodiment 3.
The invention provides a kind of concocting method of Rhizoma Polygoni Cuspidati, step is: be immersed in by 3.5g Rhizoma Polygoni Cuspidati in the pretreatment mixed solution of 10ml cellulase, beta-glucosidase, after soaking 10h, put in microwave oven and concoct 20min under 60% power, obtain Rhizoma Polygoni Cuspidati microwave processing product.
The weight proportion of described cellulase, beta-glucosidase is 5:2.
The preparation method of described pretreatment mixed solution is: take cellulase 0.5mg respectively, beta-glucosidase 0.2mg adds 10ml distilled water and dissolve and get final product, get the Pretreatment Mixed Liauid 10ml prepared and concoct for above-mentioned Rhizoma Polygoni Cuspidati.
Embodiment 4.
The invention provides a kind of concocting method of Rhizoma Polygoni Cuspidati, step is: be immersed in by 15g Rhizoma Polygoni Cuspidati in the pretreatment mixed solution of 30ml cellulase, beta-glucosidase, after soaking 8h, put in microwave oven and concoct 30min under 40% power, obtain Rhizoma Polygoni Cuspidati microwave processing product.
The weight proportion of described cellulase, beta-glucosidase is 1:1.
The preparation method of described pretreatment mixed solution is: take cellulase 3mg respectively, beta-glucosidase 3mg adds 30ml distilled water and dissolve and get final product, get the Pretreatment Mixed Liauid 30ml prepared and concoct for above-mentioned Rhizoma Polygoni Cuspidati.
Embodiment 5.
The invention provides a kind of concocting method of Rhizoma Polygoni Cuspidati, step is: be immersed in by 2g Rhizoma Polygoni Cuspidati in the pretreatment mixed solution of 10ml cellulase, beta-glucosidase, after soaking 5h, put in microwave oven and concoct 10min under 80% power, obtain Rhizoma Polygoni Cuspidati microwave processing product.
The weight proportion of described cellulase, beta-glucosidase is 1:2.5.
The preparation method of described pretreatment mixed solution is: take cellulase 1mg respectively, beta-glucosidase 2.5mg adds 30ml distilled water and dissolve and get final product, get the Pretreatment Mixed Liauid 10ml prepared and concoct for above-mentioned Rhizoma Polygoni Cuspidati.
Embodiment 6.
The invention provides a kind of concocting method of Rhizoma Polygoni Cuspidati, step is: be immersed in by 0.5g Rhizoma Polygoni Cuspidati in the pretreatment mixed solution of 5ml cellulase, beta-glucosidase, after soaking 6h, put in microwave oven and concoct 20min under 40% power, obtain Rhizoma Polygoni Cuspidati microwave processing product.
The weight proportion of described cellulase, beta-glucosidase is 1:4.
The preparation method of described pretreatment mixed solution is: take cellulase 1mg respectively, beta-glucosidase 4mg adds 5ml distilled water and dissolve and get final product, get the Pretreatment Mixed Liauid 5ml prepared and concoct for above-mentioned Rhizoma Polygoni Cuspidati.
Embodiment 7.
The invention provides a kind of concocting method of Rhizoma Polygoni Cuspidati, step is: be immersed in by 5g Rhizoma Polygoni Cuspidati in the pretreatment mixed solution of 20ml cellulase, beta-glucosidase, after soaking 3h, put in microwave oven and concoct 15min under 60% power, obtain Rhizoma Polygoni Cuspidati microwave processing product.
The weight proportion of described cellulase, beta-glucosidase is 3.5:1.
The preparation method of described pretreatment mixed solution is: take cellulase 35mg respectively, beta-glucosidase 10mg adds 20ml distilled water and dissolve and get final product, get the Pretreatment Mixed Liauid 20ml prepared and concoct for above-mentioned Rhizoma Polygoni Cuspidati.
Embodiment 8.
The invention provides a kind of concocting method of Rhizoma Polygoni Cuspidati, step is: be immersed in by 5g Rhizoma Polygoni Cuspidati in the pretreatment mixed solution of 5ml cellulase, beta-glucosidase, after soaking 12h, put in microwave oven and concoct 25min under 40% power, obtain Rhizoma Polygoni Cuspidati microwave processing product.
The weight proportion of described cellulase, beta-glucosidase is 3:4.
The preparation method of described pretreatment mixed solution is: take cellulase 1.2mg respectively, beta-glucosidase 1.6mg adds 5ml distilled water and dissolve and get final product, get the Pretreatment Mixed Liauid 5ml prepared and concoct for above-mentioned Rhizoma Polygoni Cuspidati.
Concocting method of the present invention, is also applicable to the process of preparing Chinese medicine of the Chinese medicine such as Fructus Arctii, Radix Puerariae.
Claims (7)
1. a concocting method for Rhizoma Polygoni Cuspidati, is immersed in Rhizoma Polygoni Cuspidati after soaking in the pretreatment mixed solution of cellulase, beta-glucosidase, puts in microwave oven and concocts under different capacity, obtain Rhizoma Polygoni Cuspidati microwave processing product.
2. the concocting method of Rhizoma Polygoni Cuspidati as claimed in claim 1, it is characterized in that, the preparation method of described pretreatment mixed solution is: take cellulase respectively, beta-glucosidase adding distil water dissolves and get final product.
3. the concocting method of Rhizoma Polygoni Cuspidati as claimed in claim 2, it is characterized in that, the weight proportion of described cellulase, beta-glucosidase is 1:5-5:1.
4. the concocting method of Rhizoma Polygoni Cuspidati as claimed in claim 1, it is characterized in that, total consumption of described cellulase and beta-glucosidase is the 0.1-10 ‰ of Rhizoma Polygoni Cuspidati consumption, and soak time is 2-15h.
5. the concocting method of Rhizoma Polygoni Cuspidati as claimed in claim 1, is characterized in that, concocting power used in described microwave oven is 40%-100% power, and concocted time used is 10min-30min.
6. the concocting method of Rhizoma Polygoni Cuspidati as claimed in claim 1, it is characterized in that, described Rhizoma Polygoni Cuspidati can from Different sources.
7. the concocting method of Rhizoma Polygoni Cuspidati as claimed in claim 1, it is characterized in that, described method is also applicable to the process of preparing Chinese medicine of the Chinese medicine such as Fructus Arctii, Radix Puerariae.
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