CN104474359A - Drug for treatment of children's diarrhoea and preparation method thereof - Google Patents

Drug for treatment of children's diarrhoea and preparation method thereof Download PDF

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Publication number
CN104474359A
CN104474359A CN201410650069.9A CN201410650069A CN104474359A CN 104474359 A CN104474359 A CN 104474359A CN 201410650069 A CN201410650069 A CN 201410650069A CN 104474359 A CN104474359 A CN 104474359A
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CN
China
Prior art keywords
parts
fructus
radix
semen
rhizoma
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CN201410650069.9A
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Chinese (zh)
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李彩平
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Individual
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Individual
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    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
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    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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    • A61K33/12—Magnesium silicate
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Abstract

The invention discloses a drug for the treatment of children's diarrhoea, the drug comprises chicken's gizzard membrane, polygonum aviculare, fringed pink, semen plantaginis, akebia stem, talcum, ricepaperplant pith medulla tetrapanacis, radix codonopsis, rubra poria, white atractylodes rhizome, licorice, semen nelumbinis, lentils, coix seed, radix aucklandiae, pericarpium papaveris, pulsatilla chinensis, rhizoma alismatis, papaya, rhizoma picrorhizae, Chinese yam, root of kudzu vine, balloonflower root, os draconis preparata, calcined oyster shell, gypsum, gypsum rubrum, luffa leaf, poria cocos, medicated leaven, hawthorn, magnolia bark, semen raphani, evodia, common fennel fruit, eucommia, common cnidium fruit, Chinese magnoliavine, cloves, tangerine peel, fructus aurantii immaturus, Chinese honeylocust fruit and apricot blossom, by reasonable prescription and synergistic effect of the componnets, the effect of invigorating spleen-stomach and replenishing qi, tonifying spleen, checking diarrhea, treating abdominal pain and qi stagnation can be achieved without hurting vital qi, the effectiveness can reach 96%, the drug can replenish qi to invigorate the spleen, harmonize stomach and clear heat so as to improve children's digestive system function and improve immunity.

Description

A kind of medicine for the treatment of infantile diarrhea and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of infantile diarrhea, specifically, relate to a kind of medicine for the treatment of infantile diarrhea and preparation method thereof, belong to technical field of Chinese medicine.
Background technology
Diarrhoea is 6 months--one of 2 years old infant commonly encountered diseases, accounting for half within one-year-old, is the one of the main reasons causing infantile malnutrition, dysplasia.The main inappetence of clinical manifestation, occasionally have galactorrhea or vomiting, times of defecation increases, but each stool amount is few, in yellow or yellow green, has tart flavour, and common white or yellow-white milk lobe and foam, dehydration and systemic toxicity profiles symptom can appear in severe one.
The reason that infantile diarrhea occurs has: infant digestive system development is not yet ripe, and less, enzyme activity is on the low side, can not adapt to the larger change of food quality and quantity, more weak to the killing bacteria ability entering gastric for gastric acid and digestive enzyme secretion; Growth promoter is fast, and desired nutritional material is relatively many, and pablum is based on liquid, and inlet is more, and gastrointestinal tract burden is heavy; , easily there is digestive tract function disorderly in cradle nerve, endocrine, circulation, Liver and kidney function developmental immaturity.
At present in treatment infantile diarrhea, doctor trained in Western medicine mainly adopts venoclysis antibiotic and a large amount of fluid infusion, or adopts the method for intestinal perfusion, and the medicine of above method application all has certain toxic and side effects to bring larger damage and inconvenience to infant, and therapeutic effect is not good, onset is slower.
Also there is employing traditional Chinese medical herbal treatment infantile diarrhea, although achieved necessarily curative effect, damage can have been reduced, without obvious toxic and side effects, therapeutic effect is undesirable.
Summary of the invention
The technical problem to be solved in the present invention is for above deficiency, provides a kind of medicine for the treatment of infantile diarrhea, overcomes prior art drug side effect larger, the defect that effect is undesirable, adopt described Drug therapy infantile diarrhea, therapeutic effect is obvious, reaches more than 96%.
Another object of the present invention is to provide a kind of preparation method for the treatment of infantile diarrhea medicine.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of medicine for the treatment of infantile diarrhea, is characterized in that: the raw material of the following weight part ratio of curative effect composition of described medicine: Endothelium Corneum Gigeriae Galli 5-10 part, Herba Polygoni Avicularis 5-10 part, Herba Dianthi 7-15 part, Semen Plantaginis 7-15 part, Caulis Akebiae 5-10 part, Talcum 7-15 part, Medulla Tetrapanacis 10-15 part, Radix Codonopsis 6-10 part, Poria 5-10 part, Rhizoma Atractylodis Macrocephalae 8-10 part, Radix Glycyrrhizae 5-8 part, Semen Nelumbinis 7-12 part, Seem Lablab Album 5-15 part, Semen Coicis 10-15 part, Radix Aucklandiae 2-5 part, Pericarpium Papaveris 3-5 part, Radix Pulsatillae 7-15 part, Rhizoma Alismatis 6-18 part, Fructus Chaenomelis 18-24 part, Rhizoma Picrorhizae 18-24 part, Rhizoma Dioscoreae 18-24 part, Radix Puerariae 10-16 part, Radix Platycodonis 5-9 part, Os Draconis (calcined) 18-30 part, Concha Ostreae (calcined) 15-30 part, Gypsum Fibrosum 18-30 part, Mirabilitum crystallina 20-30 part, Folium Luffae 7-15 part, Poria 7-15 part, Massa Medicata Fermentata 7-15 part, Fructus Crataegi 7-15 part, Cortex Magnoliae Officinalis 3-8 part, Semen Raphani 8-10 part, Fructus Evodiae 10-15 part, Fructus Foeniculi 7-10 part, Cortex Eucommiae 10-15 part, Fructus Cnidii 8-16 part, Fructus Schisandrae Chinensis 5-10 part, Flos Caryophylli 8-15 part, Pericarpium Citri Reticulatae 9-18 part, Fructus Aurantii Immaturus 15-20 part, Fructus Gleditsia 10-15 part and Flos Pruni 15-20 part.
A technical scheme for optimization, the raw material of the following weight part ratio of curative effect composition of described medicine: Endothelium Corneum Gigeriae Galli 5-8 part, Herba Polygoni Avicularis 8-10 part, Herba Dianthi 12-15 part, Semen Plantaginis 12-15 part, Caulis Akebiae 8-10 part, Talcum 12-15 part, Medulla Tetrapanacis 13-15 part, Radix Codonopsis 6-8 part, Poria 8-10 part, Rhizoma Atractylodis Macrocephalae 8-10 part, Radix Glycyrrhizae 7-8 part, Semen Nelumbinis 7-10 part, Seem Lablab Album 10-15 part, Semen Coicis 14-15 part, Radix Aucklandiae 3-5 part, Pericarpium Papaveris 3-5 part, Radix Pulsatillae 9-15 part, Rhizoma Alismatis 10-18 part, Fructus Chaenomelis 18-20 part, Rhizoma Picrorhizae 18-20 part, Rhizoma Dioscoreae 18-20 part, Radix Puerariae 10-14 part, Radix Platycodonis 5-8 part, Os Draconis (calcined) 20-30 part, Concha Ostreae (calcined) 20-30 part, Gypsum Fibrosum 18-25 part, Mirabilitum crystallina 20-25 part, Folium Luffae 7-10 part, Poria 7-10 part, Massa Medicata Fermentata 5-10 part, Fructus Crataegi 5-10 part, Cortex Magnoliae Officinalis 3-5 part, Semen Raphani 8-10 part, Fructus Evodiae 10-12 part, Fructus Foeniculi 7-9 part, Cortex Eucommiae 10-12 part, Fructus Cnidii 8-10 part, Fructus Schisandrae Chinensis 8-10 part, Flos Caryophylli 10-15 part, Pericarpium Citri Reticulatae 15-18 part, Fructus Aurantii Immaturus 15-16 part, Fructus Gleditsia 13-15 part and Flos Pruni 15-18 part.
A kind of technical scheme of optimization, the raw material of the following weight part ratio of curative effect composition of described medicine: Endothelium Corneum Gigeriae Galli 9 parts, Herba Polygoni Avicularis 9 parts, Herba Dianthi 10 parts, Semen Plantaginis 12 parts, Caulis Akebiae 8 parts, 12 parts, Talcum, Medulla Tetrapanacis 12 parts, Radix Codonopsis 9 parts, Poria 7 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 7 parts, Radix Glycyrrhizae, Semen Nelumbinis 8 parts, 8 parts, Seem Lablab Album, Semen Coicis 13 parts, the Radix Aucklandiae 2 parts, Pericarpium Papaveris 4 parts, the Radix Pulsatillae 9 parts, Rhizoma Alismatis 14 parts, Fructus Chaenomelis 23 parts, Rhizoma Picrorhizae 22 parts, Rhizoma Dioscoreae 24 parts, Radix Puerariae 13 parts, Radix Platycodonis 8 parts, Os Draconis (calcined) 23 parts, Concha Ostreae (calcined) 21 parts, Gypsum Fibrosum 21 parts, Mirabilitum crystallina 28 parts, Folium Luffae 13 parts, 12 parts, Poria, Massa Medicata Fermentata 11 parts, Fructus Crataegi 13 parts, Cortex Magnoliae Officinalis 4 parts, Semen Raphani 9 parts, Fructus Evodiae 15 parts, Fructus Foeniculi 7 parts, the Cortex Eucommiae 12 parts, Fructus Cnidii 8 parts, Fructus Schisandrae Chinensis 6 parts, Flos Caryophylli 10 parts, Pericarpium Citri Reticulatae 16 parts, Fructus Aurantii Immaturus 19 parts, Fructus Gleditsia 13 parts and Flos Pruni 15 parts.
Based on above medicine, the preparation method of described treatment infantile diarrhea medicine comprises the following steps:
A, take each raw material respectively according to weight portion;
B, boiling hot Endothelium Corneum Gigeriae Galli processed: get sand and put in pot, make popular with moderate heat, adding the whole broken clean Endothelium Corneum Gigeriae Galli separated, stirring to heaving, crisp, take out, sieve removes sand, cools.
C, Radix Aucklandiae (roasted): get wheat bran and add clear water and mix thoroughly slightly vexed in right amount, degree hands can be held agglomerating, not loose is degree.Radix Aucklandiae wheat bran is buried, slow fire heating is stirred and is made Radix Aucklandiae thermally equivalent, rear firepower slightly large a large amount of evaporations along with moisture can smell the volatile oil abnormal smells from the patient of the Radix Aucklandiae, treat that moisture evaporation will be use up, reduce firepower, slow fire stir-fry is coke yellow to the large portion of wheat bran is degree, and the sieve that takes the dish out of the pot removes wheat bran, cut into slices while hot or smash to pieces, cooling for subsequent use.(every 16 jin of the Radix Aucklandiae, with 6 jin, wheat bran)
D, Rhizoma Dioscoreae processed: get Testa Tritici 2kg, Mel 100g, Chinese liquor 50ml mixes thoroughly, puts moderate heat in pot and fries to pouring yam slice 10kg when smoldering into, constantly stir, and fries to turning to be yellow as degree.(every 10 jin of Rhizoma Dioscoreae, with 2 jin, Testa Tritici, Mel 1 jin, Chinese liquor 1 jin)
E, processed with Rhizoma Zingiberis Recens Radix Platycodonis: get clean Radix Platycodonis, Sucus Zingberis, put in basin and mix thoroughly, vexed about 1h, after proceed in pot with slow fire fry all parch to medical material, crust be faint yellow, take out weigh while hot, pulverizing, obtain coarse powder.(the every 80g of Radix Platycodonis, Sucus Zingberis 16ml)
F, Massa Medicata Fermentata processed: Semen Armeniacae Amarum, Semen Phaseoli being crushed into powder mixes with flour, add fresh Herba Artemisiae Annuae, Herba polygoni hydropiperis, Herba Xanthii grass decoct juice, make soft, be pressed into flat square, with fresh Herba Abutili leaf Bao Yan, put into case, cover fresh Herba Artemisiae Annuae above, 30 ~ 37 DEG C, fermentation in 4 ~ 6 days, take out when powder bears HUANGBAI(sic) mould clothing, removing Herba Abutili leaf, is cut into small pieces.(the every 1kg of Massa Medicata Fermentata, Semen Armeniacae Amarum 4kg, Semen Phaseoli 4kg, flour 100kg, fresh Herba Artemisiae Annuae 7kg, Herba polygoni hydropiperis 7kg, Herba Xanthii grass 7kg)
G, Semen Coicis processed: the Semen Coicis getting screening wholegrain is cleaned, and soaks 24h, puts water proof intense fire in wooden steamer and take the dish out of the pot after cooking, clear water is drenched, it is dry that foot is shone in airing, put in pot heat with hot sand intense fire and drop into Semen Coicis fry to Semen Coicis entirety turn white, fat large, pine bubble degree of being, taking-up sieve reduces phlegm and internal heat sand.
H, Seem Lablab Album processed: put in clear water by raw Seem Lablab Album and soak 3h, pick up and drain when skin is slightly soft, sand in pot is heated to high heat sliding profit, when namely stirring flexible, just Seem Lablab Album is embedded in hot sand and simmers about 5min, or else disconnected fry to crisp have burnt odor gas time, take out sieve shakeout.
J, Flos Pruni processed: get fresh Flos Pruni and soak 2h in clear water, get flour and add Flos Pruni and the mixing of a small amount of water, make pancake, iron limit spray a little Chinese liquor at pot inner edge, well-done to pancake, dry in the air cool after, pulverize.(the every 1kg of Flos Pruni, flour 5kg)
K, by Herba Polygoni Avicularis, Herba Dianthi, Semen Plantaginis, Caulis Akebiae, Talcum, Medulla Tetrapanacis, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Semen Nelumbinis, Pericarpium Papaveris, the Radix Pulsatillae, Rhizoma Alismatis, Fructus Chaenomelis, Rhizoma Picrorhizae, Radix Puerariae, Os Draconis (calcined), Concha Ostreae (calcined), Fructus Evodiae, Fructus Foeniculi, the Cortex Eucommiae, Fructus Cnidii, Fructus Schisandrae Chinensis, Flos Caryophylli, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Fructus Gleditsia, Gypsum Fibrosum, Mirabilitum crystallina, Folium Luffae, Poria, Fructus Crataegi, Cortex Magnoliae Officinalis, Semen Raphani and boiling hot Endothelium Corneum Gigeriae Galli processed and Radix Aucklandiae (roasted), Rhizoma Dioscoreae processed, processed with Rhizoma Zingiberis Recens Radix Platycodonis, Massa Medicata Fermentata processed, Semen Coicis processed, Flos Pruni processed, Seem Lablab Album mixing processed, pulverize with pulverizer, cross 120 mesh sieves and become smalls,
1, bag hermetic package is divided by above smalls.
The using method for the treatment of infantile diarrhea Chinese medicine comprises the following steps:
A, Chinese medicine smalls and the Mel of tempering to be mixed by 1: 1.5, rubbing and ball, every pill 0.3g.
B, one time 10, every day three times is oral.
C, external application umbilicus are treated: Fructus Forsythiae 3g, 10, Fructus Piperis, Pericarpium Citri Reticulatae Viride 10g, Rhizoma Atractylodis 10g, grind the non-1g of each medication into powder, with mature vinegar or Oleum Sesami furnishing pasty state.Cleaned by umbilicus, the drug of topical application after routine disinfection, rubber plaster is topped on it, every day 1 time.
The pharmacology of above Chinese medicine is:
Herba Dianthi, Caulis Akebiae, Talcum, Herba Polygoni Avicularis, Pericarpium Papaveris, the Radix Aucklandiae, Massa Medicata Fermentata processed, the Radix Pulsatillae have effect of clearing heat and freeing strangury; Effect of Radix Puerariae, Os Draconis (calcined), Concha Ostreae (calcined), Gypsum Fibrosum, Rhizoma Dioscoreae, Mirabilitum crystallina, Semen Plantaginis diuretic antidiarrheal, stomach function regulating; The Rhizoma Atractylodis Macrocephalae, Semen Coicis, Endothelium Corneum Gigeriae Galli, Poria, Radix Codonopsis, Poria, Semen Nelumbinis, Fructus Crataegi, Cortex Magnoliae Officinalis, processed with Rhizoma Zingiberis Recens Radix Platycodonis, Seem Lablab Album, Semen Raphani have effect of invigorating spleen to remove dampness; Rhizoma Alismatis, Fructus Chaenomelis, Radix Glycyrrhizae, Rhizoma Picrorhizae, Medulla Tetrapanacis, Folium Luffae have effect of promoting diuresis to eliminate damp pathogen; Fructus Evodiae, Fructus Foeniculi, the Cortex Eucommiae, Fructus Cnidii, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae have effect of cold expelling circulation of qi promoting; Flos Caryophylli, Fructus Aurantii Immaturus, Fructus Gleditsia, Flos Pruni have effect of removing food stagnancy pain relieving, and above each composition compatibility is reasonable, and mutual synergism, makes it jointly reach invigorating the spleen and replenishing QI eventually, and invigorating the spleen to arrest diarrhea, abdominal pain due to stagnation of QI and do not hinder effect of healthy energy, through testing, effective percentage reaches more than 96%.
The present invention adopts above technical scheme, has obvious diuretic anti-diarrhea effect to infantile diarrhea, simultaneously can replenishing QI to invigorate the spleen, stomach function regulating heat clearing away, thus promote children's digestive system function, improve immunity.
Below in conjunction with detailed description of the invention to technical scheme further instruction of the present invention.
Detailed description of the invention
Embodiment 1, a kind of medicine for the treatment of infantile diarrhea, the raw material of the following weight part ratio of its curative effect composition: Endothelium Corneum Gigeriae Galli 10 parts, Herba Polygoni Avicularis 50 parts, Herba Dianthi 15 parts, Semen Plantaginis 13 parts, Caulis Akebiae 5 parts, 7 parts, Talcum, Medulla Tetrapanacis 14 parts, Radix Codonopsis 6 parts, Poria 5 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, 6 parts, Radix Glycyrrhizae, Semen Nelumbinis 9 parts, 15 parts, Seem Lablab Album, Semen Coicis 10 parts, the Radix Aucklandiae 3 parts, Pericarpium Papaveris 3 parts, the Radix Pulsatillae 7 parts, Rhizoma Alismatis 6 parts, Fructus Chaenomelis 18 parts, Rhizoma Picrorhizae 18 parts, Rhizoma Dioscoreae 20 parts, Radix Puerariae 16 parts, Radix Platycodonis 6 parts, Os Draconis (calcined) 18 parts, Concha Ostreae (calcined) 15 parts, Gypsum Fibrosum 18 parts, Mirabilitum crystallina 30 parts, Folium Luffae 7 parts, 15 parts, Poria, Massa Medicata Fermentata 15 parts, Fructus Crataegi 7 parts, Cortex Magnoliae Officinalis 8 parts, Semen Raphani 10 parts, Fructus Evodiae 13 parts, Fructus Foeniculi 8 parts, the Cortex Eucommiae 15 parts, Fructus Cnidii 11 parts, Fructus Schisandrae Chinensis 5 parts, Flos Caryophylli 8 parts, Pericarpium Citri Reticulatae 9 parts, Fructus Aurantii Immaturus 20 parts, Fructus Gleditsia 11 parts and Flos Pruni 20 parts.
Embodiment 2, a kind of medicine for the treatment of infantile diarrhea, the raw material of the following weight part ratio of its curative effect composition: Endothelium Corneum Gigeriae Galli 6 parts, Herba Polygoni Avicularis 7 parts, Herba Dianthi 12 parts, Semen Plantaginis 10 parts, Caulis Akebiae 9 parts, 15 parts, Talcum, Medulla Tetrapanacis 13 parts, Radix Codonopsis 8 parts, Poria 9 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, 7 parts, Radix Glycyrrhizae, Semen Nelumbinis 10 parts, 12 parts, Seem Lablab Album, Semen Coicis 14 parts, the Radix Aucklandiae 5 parts, Pericarpium Papaveris 5 parts, the Radix Pulsatillae 14 parts, Rhizoma Alismatis 18 parts, Fructus Chaenomelis 21 parts, Rhizoma Picrorhizae 19 parts, Rhizoma Dioscoreae 23 parts, Radix Puerariae 14 parts, Radix Platycodonis 9 parts, Os Draconis (calcined) 30 parts, Concha Ostreae (calcined) 25 parts, Gypsum Fibrosum 30 parts, Mirabilitum crystallina 25 parts, Folium Luffae 7 parts, 14 parts, Poria, Massa Medicata Fermentata 9 parts, Fructus Crataegi 8 parts, Cortex Magnoliae Officinalis 3 parts, Semen Raphani 8 parts, Fructus Evodiae 11 parts, Fructus Foeniculi 9 parts, the Cortex Eucommiae 14 parts, Fructus Cnidii 14 parts, Fructus Schisandrae Chinensis 10 parts, Flos Caryophylli 13 parts, Pericarpium Citri Reticulatae 11 parts, Fructus Aurantii Immaturus 18 parts, Fructus Gleditsia 14 parts and Flos Pruni 19 parts.
Embodiment 3, a kind of medicine for the treatment of infantile diarrhea, the raw material of the following weight part ratio of its curative effect composition: Endothelium Corneum Gigeriae Galli 8 parts, Herba Polygoni Avicularis 10 parts, Herba Dianthi 9 parts, Semen Plantaginis 15 parts, Caulis Akebiae 10 parts, 10 parts, Talcum, Medulla Tetrapanacis 15 parts, Radix Codonopsis 10 parts, Poria 10 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, 8 parts, Radix Glycyrrhizae, Semen Nelumbinis 7 parts, 5 parts, Seem Lablab Album, Semen Coicis 15 parts, the Radix Aucklandiae 5 parts, Pericarpium Papaveris 3 parts, the Radix Pulsatillae 15 parts, Rhizoma Alismatis 15 parts, Fructus Chaenomelis 20 parts, Rhizoma Picrorhizae 20 parts, Rhizoma Dioscoreae 22 parts, Radix Puerariae 15 parts, Radix Platycodonis 5 parts, Os Draconis (calcined) 25 parts, Concha Ostreae (calcined) 30 parts, Gypsum Fibrosum 25 parts, Mirabilitum crystallina 20 parts, Folium Luffae 15 parts, 10 parts, Poria, Massa Medicata Fermentata 10 parts, Fructus Crataegi 15 parts, Cortex Magnoliae Officinalis 6 parts, Semen Raphani 8 parts, Fructus Evodiae 10 parts, Fructus Foeniculi 8 parts, the Cortex Eucommiae 10 parts, Fructus Cnidii 10 parts, Fructus Schisandrae Chinensis 8 parts, Flos Caryophylli 15 parts, Pericarpium Citri Reticulatae 18 parts, Fructus Aurantii Immaturus 16 parts, Fructus Gleditsia 15 parts and Flos Pruni 18 parts.
Embodiment 4, a kind of medicine for the treatment of infantile diarrhea, the raw material of the following weight part ratio of its curative effect composition: Endothelium Corneum Gigeriae Galli 9 parts, Herba Polygoni Avicularis 9 parts, Herba Dianthi 10 parts, Semen Plantaginis 12 parts, Caulis Akebiae 8 parts, 12 parts, Talcum, Medulla Tetrapanacis 12 parts, Radix Codonopsis 9 parts, Poria 7 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 7 parts, Radix Glycyrrhizae, Semen Nelumbinis 8 parts, 8 parts, Seem Lablab Album, Semen Coicis 13 parts, the Radix Aucklandiae 2 parts, Pericarpium Papaveris 4 parts, the Radix Pulsatillae 9 parts, Rhizoma Alismatis 14 parts, Fructus Chaenomelis 23 parts, Rhizoma Picrorhizae 22 parts, Rhizoma Dioscoreae 24 parts, Radix Puerariae 13 parts, Radix Platycodonis 8 parts, Os Draconis (calcined) 23 parts, Concha Ostreae (calcined) 21 parts, Gypsum Fibrosum 21 parts, Mirabilitum crystallina 28 parts, Folium Luffae 13 parts, 12 parts, Poria, Massa Medicata Fermentata 11 parts, Fructus Crataegi 13 parts, Cortex Magnoliae Officinalis 4 parts, Semen Raphani 9 parts, Fructus Evodiae 15 parts, Fructus Foeniculi 7 parts, the Cortex Eucommiae 12 parts, Fructus Cnidii 8 parts, Fructus Schisandrae Chinensis 6 parts, Flos Caryophylli 10 parts, Pericarpium Citri Reticulatae 16 parts, Fructus Aurantii Immaturus 19 parts, Fructus Gleditsia 13 parts and Flos Pruni 15 parts.
Embodiment 5, a kind of medicine for the treatment of infantile diarrhea, the raw material of the following weight part ratio of its curative effect composition: Endothelium Corneum Gigeriae Galli 5 parts, Herba Polygoni Avicularis 8 parts, Herba Dianthi 7 parts, Semen Plantaginis 7 parts, Caulis Akebiae 6 parts, 9 parts, Talcum, Medulla Tetrapanacis 10 parts, Radix Codonopsis 7 parts, Poria 8 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, 5 parts, Radix Glycyrrhizae, Semen Nelumbinis 12 parts, 10 parts, Seem Lablab Album, Semen Coicis 12 parts, the Radix Aucklandiae 4 parts, Pericarpium Papaveris 5 parts, the Radix Pulsatillae 12 parts, Rhizoma Alismatis 9 parts, Fructus Chaenomelis 24 parts, Rhizoma Picrorhizae 23 parts, Rhizoma Dioscoreae 18 parts, Radix Puerariae 10 parts, Radix Platycodonis 7 parts, Os Draconis (calcined) 20 parts, Concha Ostreae (calcined) 16 parts, Gypsum Fibrosum 22 parts, Mirabilitum crystallina 23 parts, Folium Luffae 12 parts, 7 parts, Poria, Massa Medicata Fermentata 7 parts, Fructus Crataegi 10 parts, Cortex Magnoliae Officinalis 5 parts, Semen Raphani 10 parts, Fructus Evodiae 12 parts, Fructus Foeniculi 9 parts, the Cortex Eucommiae 13 parts, Fructus Cnidii 16 parts, Fructus Schisandrae Chinensis 8 parts, Flos Caryophylli 11 parts, Pericarpium Citri Reticulatae 13 parts, Fructus Aurantii Immaturus 15 parts, Fructus Gleditsia 12 parts and Flos Pruni 16 parts.
The medicine of above five embodiments is prepared according to following steps respectively:
A, take each raw material respectively according to weight portion;
B, boiling hot Endothelium Corneum Gigeriae Galli processed: get sand and put in pot, make popular with moderate heat, adding the whole broken clean Endothelium Corneum Gigeriae Galli separated, stirring to heaving, crisp, take out, sieve removes sand, cools.
C, Radix Aucklandiae (roasted): get wheat bran and add clear water and mix thoroughly slightly vexed in right amount, degree hands can be held agglomerating, not loose is degree.Radix Aucklandiae wheat bran is buried, slow fire heating is stirred and is made Radix Aucklandiae thermally equivalent, rear firepower slightly large a large amount of evaporations along with moisture can smell the volatile oil abnormal smells from the patient of the Radix Aucklandiae, treat that moisture evaporation will be use up, reduce firepower, slow fire stir-fry is coke yellow to the large portion of wheat bran is degree, and the sieve that takes the dish out of the pot removes wheat bran, cut into slices while hot or smash to pieces, cooling for subsequent use.(every 16 jin of the Radix Aucklandiae, with 6 jin, wheat bran)
D, Rhizoma Dioscoreae processed: get Testa Tritici 2kg, Mel 100g, Chinese liquor 50ml mixes thoroughly, puts moderate heat in pot and fries to pouring yam slice 10kg when smoldering into, constantly stir, and fries to turning to be yellow as degree.(every 10 jin of Rhizoma Dioscoreae, with 2 jin, Testa Tritici, Mel 1 jin, Chinese liquor 1 jin)
E, processed with Rhizoma Zingiberis Recens Radix Platycodonis: get clean Radix Platycodonis, Sucus Zingberis, put in basin and mix thoroughly, vexed about 1h, after proceed in pot with slow fire fry all parch to medical material, crust be faint yellow, take out weigh while hot, pulverizing, obtain coarse powder.(the every 80g of Radix Platycodonis, Sucus Zingberis 16ml)
F, Massa Medicata Fermentata processed: Semen Armeniacae Amarum, Semen Phaseoli being crushed into powder mixes with flour, add fresh Herba Artemisiae Annuae, Herba polygoni hydropiperis, Herba Xanthii grass decoct juice, make soft, be pressed into flat square, with fresh Herba Abutili leaf Bao Yan, put into case, cover fresh Herba Artemisiae Annuae above, 30 ~ 37 DEG C, fermentation in 4 ~ 6 days, take out when powder bears HUANGBAI(sic) mould clothing, removing Herba Abutili leaf, is cut into small pieces.(the every 1kg of Massa Medicata Fermentata, Semen Armeniacae Amarum 4kg, Semen Phaseoli 4kg, flour 100kg, fresh Herba Artemisiae Annuae 7kg, Herba polygoni hydropiperis 7kg, Herba Xanthii grass 7kg)
G, Semen Coicis processed: the Semen Coicis getting screening wholegrain is cleaned, and soaks 24h, puts water proof intense fire in wooden steamer and take the dish out of the pot after cooking, clear water is drenched, it is dry that foot is shone in airing, put in pot heat with hot sand intense fire and drop into Semen Coicis fry to Semen Coicis entirety turn white, fat large, pine bubble degree of being, taking-up sieve reduces phlegm and internal heat sand.
H, Seem Lablab Album processed: put in clear water by raw Seem Lablab Album and soak 3h, pick up and drain when skin is slightly soft, sand in pot is heated to high heat sliding profit, when namely stirring flexible, just Seem Lablab Album is embedded in hot sand and simmers about 5min, or else disconnected fry to crisp have burnt odor gas time, take out sieve shakeout.
J, Flos Pruni processed: get Flos Pruni and soak 2h in clear water, get flour and add Flos Pruni and the mixing of a small amount of water, make pancake, iron limit spray a little Chinese liquor at pot inner edge, well-done to pancake, dry in the air cool after, pulverize.(the every 1kg of Flos Pruni, flour 5kg)
K, by Herba Polygoni Avicularis, Herba Dianthi, Semen Plantaginis, Caulis Akebiae, Talcum, Medulla Tetrapanacis, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Semen Nelumbinis, Pericarpium Papaveris, the Radix Pulsatillae, Rhizoma Alismatis, Fructus Chaenomelis, Rhizoma Picrorhizae, Radix Puerariae, Os Draconis (calcined), Concha Ostreae (calcined), Fructus Evodiae, Fructus Foeniculi, the Cortex Eucommiae, Fructus Cnidii, Fructus Schisandrae Chinensis, Flos Caryophylli, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Fructus Gleditsia, Gypsum Fibrosum, Mirabilitum crystallina, Folium Luffae, Poria, Fructus Crataegi, Cortex Magnoliae Officinalis, Semen Raphani and boiling hot Endothelium Corneum Gigeriae Galli processed and Radix Aucklandiae (roasted), Rhizoma Dioscoreae processed, processed with Rhizoma Zingiberis Recens Radix Platycodonis, Massa Medicata Fermentata processed, Semen Coicis processed, Flos Pruni processed, Seem Lablab Album mixing processed, pulverize with pulverizer, cross 120 mesh sieves and become smalls,
1, bag hermetic package is divided by above smalls.
The using method for the treatment of infantile diarrhea Chinese medicine comprises the following steps:
A, Chinese medicine smalls and the Mel of tempering to be mixed by 1: 1.5, rubbing and ball, every pill 0.3g.
B, one time 10, every day three times is oral.
C, external application umbilicus are treated: Fructus Forsythiae 3g, 10, Fructus Piperis, Pericarpium Citri Reticulatae Viride 10g, Rhizoma Atractylodis 10g, grind the non-1g of each medication into powder, with mature vinegar or Oleum Sesami furnishing pasty state.Cleaned by umbilicus, the drug of topical application after routine disinfection, rubber plaster is topped on it, every day 1 time.
Treatment time is generally 4-6 days.
Clinical effectiveness confirmatory experiment
The 180 routine Diarrheas that year October in July, 2010 to 2014 seeks medical advice, infant disease meets " paediatric internal medicine " the 3rd edition infantile diarrhea diagnostic criteria.180 examples are all verified is noninfectious diarrhea, with dewatering symptom in various degree.Man 67 example, female 113 example, 6 months-2 years old age, the course of disease 1 day to 5 days.
Arrange 5 test group altogether, each test group random assortment patient treats.Test group 1 uses the Drug therapy of embodiment 1 gained, test group 2 uses the Drug therapy of embodiment 2 gained, test group 3 uses the Drug therapy of embodiment 3 gained, test group 4 uses the Drug therapy of embodiment 4 gained, test group 5 uses the Drug therapy of the embodiment of the present invention 5 gained, if 30 examples are matched group, matched group adopts the method treatment of doctor trained in Western medicine venous transfusion and enteric cavity perfusion, total effective rate 73.3%.
Efficacy assessment standard
Effective: diarrhoea is alleviated, and without Nausea and vomiting and colic symptoms, stool is normal; Take a turn for the better: diarrhoea alleviates, and times of defecation < 3 times/24h, without Nausea and vomiting and colic symptoms, defecates slightly thin; Worsen: symptom of diarrhea increases the weight of, with Nausea and vomiting and colic symptoms, obviously, stool is in rare water sample in dehydration.
The result that test obtains is as following table:
Find out from above data, the medicine of gained treatment infantile diarrhea of the present invention, total effective rate reaches more than 90.0%, and without obvious toxic-side effects, in the embodiment above, embodiment 4 is preferred plan.
Those skilled in the art will recognize that; above-mentioned detailed description of the invention is exemplary; to enable those skilled in the art better understand content of the present invention; should not be understood as limiting the scope of the invention; as long as according to the improvement that technical solution of the present invention is done; and realize and identical effect of the present invention, all fall into protection scope of the present invention.

Claims (4)

1. treat a medicine for infantile diarrhea, it is characterized in that, the raw material of the following weight part ratio of curative effect composition of described medicine:
Endothelium Corneum Gigeriae Galli 5-10 part, Herba Polygoni Avicularis 5-10 part, Herba Dianthi 7-15 part, Semen Plantaginis 7-15 part, Caulis Akebiae 5-10 part, Talcum 7-15 part, Medulla Tetrapanacis 10-15 part, Radix Codonopsis 6-10 part, Poria 5-10 part, Rhizoma Atractylodis Macrocephalae 8-10 part, Radix Glycyrrhizae 5-8 part, Semen Nelumbinis 7-12 part, Seem Lablab Album 5-15 part, Semen Coicis 10-15 part, Radix Aucklandiae 2-5 part, Pericarpium Papaveris 3-5 part, Radix Pulsatillae 7-15 part, Rhizoma Alismatis 6-18 part, Fructus Chaenomelis 18-24 part, Rhizoma Picrorhizae 18-24 part, Rhizoma Dioscoreae 18-24 part, Radix Puerariae 10-16 part, Radix Platycodonis 5-9 part, Os Draconis (calcined) 18-30 part, Concha Ostreae (calcined) 15-30 part, Gypsum Fibrosum 18-30 part, Mirabilitum crystallina 20-30 part, Folium Luffae 7-15 part, Poria 7-15 part, Massa Medicata Fermentata 7-15 part, Fructus Crataegi 7-15 part, Cortex Magnoliae Officinalis 3-8 part, Semen Raphani 8-10 part, Fructus Evodiae 10-15 part, Fructus Foeniculi 7-10 part, Cortex Eucommiae 10-15 part, Fructus Cnidii 8-16 part, Fructus Schisandrae Chinensis 5-10 part, Flos Caryophylli 8-15 part, Pericarpium Citri Reticulatae 9-18 part, Fructus Aurantii Immaturus 15-20 part, Fructus Gleditsia 10-15 part and Flos Pruni 15-20 part.
2. medicine as claimed in claim 1, is characterized in that, the raw material of the following weight part ratio of curative effect composition of described medicine:
Endothelium Corneum Gigeriae Galli 5-8 part, Herba Polygoni Avicularis 8-10 part, Herba Dianthi 12-15 part, Semen Plantaginis 12-15 part, Caulis Akebiae 8-10 part, Talcum 12-15 part, Medulla Tetrapanacis 13-15 part, Radix Codonopsis 6-8 part, Poria 8-10 part, Rhizoma Atractylodis Macrocephalae 8-10 part, Radix Glycyrrhizae 7-8 part, Semen Nelumbinis 7-10 part, Seem Lablab Album 10-15 part, Semen Coicis 14-15 part, Radix Aucklandiae 3-5 part, Pericarpium Papaveris 3-5 part, Radix Pulsatillae 9-15 part, Rhizoma Alismatis 10-18 part, Fructus Chaenomelis 18-20 part, Rhizoma Picrorhizae 18-20 part, Rhizoma Dioscoreae 18-20 part, Radix Puerariae 10-14 part, Radix Platycodonis 5-8 part, Os Draconis (calcined) 20-30 part, Concha Ostreae (calcined) 20-30 part, Gypsum Fibrosum 18-25 part, Mirabilitum crystallina 20-25 part, Folium Luffae 7-10 part, Poria 7-10 part, Massa Medicata Fermentata 5-10 part, Fructus Crataegi 5-10 part, Cortex Magnoliae Officinalis 3-5 part, Semen Raphani 8-10 part, Fructus Evodiae 10-12 part, Fructus Foeniculi 7-9 part, Cortex Eucommiae 10-12 part, Fructus Cnidii 8-10 part, Fructus Schisandrae Chinensis 8-10 part, Flos Caryophylli 10-15 part, Pericarpium Citri Reticulatae 15-18 part, Fructus Aurantii Immaturus 15-16 part, Fructus Gleditsia 13-15 part and Flos Pruni 15-18 part.
3. medicine as claimed in claim 1, is characterized in that, the raw material of the following weight part ratio of curative effect composition of described medicine:
Endothelium Corneum Gigeriae Galli 9 parts, Herba Polygoni Avicularis 9 parts, Herba Dianthi 10 parts, Semen Plantaginis 12 parts, Caulis Akebiae 8 parts, 12 parts, Talcum, Medulla Tetrapanacis 12 parts, Radix Codonopsis 9 parts, Poria 7 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 7 parts, Radix Glycyrrhizae, Semen Nelumbinis 8 parts, 8 parts, Seem Lablab Album, Semen Coicis 13 parts, the Radix Aucklandiae 2 parts, Pericarpium Papaveris 4 parts, the Radix Pulsatillae 9 parts, Rhizoma Alismatis 14 parts, Fructus Chaenomelis 23 parts, Rhizoma Picrorhizae 22 parts, Rhizoma Dioscoreae 24 parts, Radix Puerariae 13 parts, Radix Platycodonis 8 parts, Os Draconis (calcined) 23 parts, Concha Ostreae (calcined) 21 parts, Gypsum Fibrosum 21 parts, Mirabilitum crystallina 28 parts, Folium Luffae 13 parts, 12 parts, Poria, Massa Medicata Fermentata 11 parts, Fructus Crataegi 13 parts, Cortex Magnoliae Officinalis 4 parts, Semen Raphani 9 parts, Fructus Evodiae 15 parts, Fructus Foeniculi 7 parts, the Cortex Eucommiae 12 parts, Fructus Cnidii 8 parts, Fructus Schisandrae Chinensis 6 parts, Flos Caryophylli 10 parts, Pericarpium Citri Reticulatae 16 parts, Fructus Aurantii Immaturus 19 parts, Fructus Gleditsia 13 parts and Flos Pruni 15 parts.
4. the preparation method of medicine as described in claim 1-3, it is characterized in that, described preparation method comprises the following steps:
A, take each raw material respectively according to weight portion;
B, boiling hot Endothelium Corneum Gigeriae Galli processed: get sand and put in pot, make popular with moderate heat, adding the whole broken clean Endothelium Corneum Gigeriae Galli separated, stirring to heaving, crisp, take out, sieve removes sand, cools;
C, Radix Aucklandiae (roasted): get wheat bran and add clear water and mix thoroughly slightly vexed in right amount, degree hands can be held agglomerating, not loose is degree; Radix Aucklandiae wheat bran is buried, slow fire heating is stirred and is made Radix Aucklandiae thermally equivalent, rear firepower slightly large a large amount of evaporations along with moisture can smell the volatile oil abnormal smells from the patient of the Radix Aucklandiae, treat that moisture evaporation will be use up, reduce firepower, slow fire stir-fry is coke yellow to the large portion of wheat bran is degree, and the sieve that takes the dish out of the pot removes wheat bran, cut into slices while hot or smash to pieces, cooling for subsequent use;
D, Rhizoma Dioscoreae processed: get Testa Tritici 2kg, Mel 100g, Chinese liquor 50ml mixes thoroughly, puts moderate heat in pot and fries to pouring yam slice 10kg when smoldering into, constantly stir, and fries to turning to be yellow as degree;
E, processed with Rhizoma Zingiberis Recens Radix Platycodonis: get clean Radix Platycodonis, Sucus Zingberis, put in basin and mix thoroughly, vexed about 1h, after proceed in pot with slow fire fry all parch to medical material, crust be faint yellow, take out weigh while hot, pulverizing, obtain coarse powder;
F, Massa Medicata Fermentata processed: Semen Armeniacae Amarum, Semen Phaseoli being crushed into powder mixes with flour, add fresh Herba Artemisiae Annuae, Herba polygoni hydropiperis, Herba Xanthii grass decoct juice, make soft, be pressed into flat square, with fresh Herba Abutili leaf Bao Yan, put into case, cover fresh Herba Artemisiae Annuae above, 30 ~ 37 DEG C, fermentation in 4 ~ 6 days, take out when powder bears HUANGBAI(sic) mould clothing, removing Herba Abutili leaf, is cut into small pieces;
G, Semen Coicis processed: the Semen Coicis getting screening wholegrain is cleaned, and soaks 24h, puts water proof intense fire in wooden steamer and take the dish out of the pot after cooking, clear water is drenched, it is dry that foot is shone in airing, put in pot heat with hot sand intense fire and drop into Semen Coicis fry to Semen Coicis entirety turn white, fat large, pine bubble degree of being, taking-up sieve reduces phlegm and internal heat sand;
H, Seem Lablab Album processed: put in clear water by raw Seem Lablab Album and soak 3h, pick up and drain when skin is slightly soft, sand in pot is heated to high heat sliding profit, when namely stirring flexible, just Seem Lablab Album is embedded in hot sand and simmers about 5min, or else disconnected fry to crisp have burnt odor gas time, take out sieve shakeout;
J, Flos Pruni processed: get fresh Flos Pruni and soak 2h in clear water, get flour and add Flos Pruni and the mixing of a small amount of water, make pancake, iron limit spray a little Chinese liquor at pot inner edge, well-done to pancake, dry in the air cool after, pulverize;
K, by Herba Polygoni Avicularis, Herba Dianthi, Semen Plantaginis, Caulis Akebiae, Talcum, Medulla Tetrapanacis, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Semen Nelumbinis, Pericarpium Papaveris, the Radix Pulsatillae, Rhizoma Alismatis, Fructus Chaenomelis, Rhizoma Picrorhizae, Radix Puerariae, Os Draconis (calcined), Concha Ostreae (calcined), Fructus Evodiae, Fructus Foeniculi, the Cortex Eucommiae, Fructus Cnidii, Fructus Schisandrae Chinensis, Flos Caryophylli, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Fructus Gleditsia, Gypsum Fibrosum, Mirabilitum crystallina, Folium Luffae, Poria, Fructus Crataegi, Cortex Magnoliae Officinalis, Semen Raphani and boiling hot Endothelium Corneum Gigeriae Galli processed and Radix Aucklandiae (roasted), Rhizoma Dioscoreae processed, processed with Rhizoma Zingiberis Recens Radix Platycodonis, Massa Medicata Fermentata processed, Semen Coicis processed, Flos Pruni processed, Seem Lablab Album mixing processed, pulverize with pulverizer, cross 120 mesh sieves and become smalls,
L, divide bag hermetic package by above smalls.
CN201410650069.9A 2014-11-06 2014-11-06 Drug for treatment of children's diarrhoea and preparation method thereof Pending CN104474359A (en)

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CN110353079A (en) * 2019-08-19 2019-10-22 江西古汉精制中药饮片有限公司 A kind of production method of secret semen coicis

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CN110353079A (en) * 2019-08-19 2019-10-22 江西古汉精制中药饮片有限公司 A kind of production method of secret semen coicis

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