CN104398236A - Large-field-of-view fundus imaging device - Google Patents
Large-field-of-view fundus imaging device Download PDFInfo
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- CN104398236A CN104398236A CN201410784697.6A CN201410784697A CN104398236A CN 104398236 A CN104398236 A CN 104398236A CN 201410784697 A CN201410784697 A CN 201410784697A CN 104398236 A CN104398236 A CN 104398236A
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Abstract
The invention relates to a large-field-of-view fundus imaging device. The device comprises a device case, wherein a lighting module, an eye objective lens module, a field lens module, an imaging objective lens module and an imaging module are sequentially and coaxially mounted on the upper side inside the case from left to right, and a focusing module for adjusting the imaging module to move horizontally and axially is mounted below the imaging module. According to the imaging device, LEDs are used as lighting sources, the divergence angle is larger than 80 degrees, a uniform lighting field of view at 120 degrees is formed at the human eye fundus, USB3.0 data interfaces are adopted, color real-time image pickup at 20 frames per second can be performed on the fundus of a human eye after mydriasis, an image surface movement focusing mode is adopted, the overall light path structure is simplified, the device is reasonable in structure, and the size of equipment is greatly reduced.
Description
Technical field
The invention belongs to ophthalmic medical equipment technical field, what relate to is a kind of using LED as lighting source, by the Large visual angle fundus imaging device of optical lens and CCD/CMOS imaging, the image of shooting is used for the examination of fundus oculi disease, is specially adapted to the early diagnosis of premature infant's eye ground pathological changes and postoperative check.
Background technology
Retina image-forming technology has been widely used in optical fundus detection field.Medical science shows, the systemic disease of ophthalmic diseases and health all can produce pathological changes at eye ground in early days in morbidity.Carry out accurately, timely detecting to retinopathy, great effect can be played to the early diagnosis of disease, also can provide a good platform to the pathological research of major disease.A complete retina optical imaging system should be made up of fundus illumination light path and fundus imaging light path.In addition, system also should have enough large refraction compensation scope, meets the demand of the human eye of different diopter being carried out to blur-free imaging.According to the difference of clinical demand, instrument performance also varies, but is the future development to Large visual angle, high-resolution and colour imaging generally.
For common fundus camera, its imaging viewing field is generally about 40 degree, and this brings bottleneck to the diagnosis of a lot of disease.Such as, clinically the early screening of the eye ground pathological changes of premature infant is needed to the imaging viewing field of more than 120 degree.This kind of disease can be fully recovered by laser surgery in early days in morbidity, but exceed the time limit just can cause blind throughout one's life.
When carrying out Large visual angle imaging to optical fundus, the angle of incidence of light on cornea that eye ground peripheral field reflects pupil can exceed critical angle formation total reflection, makes it enter imaging system.Therefore, the eyeglass group of contact must be used could to realize the fundus imaging of Large visual angle.The material selection of the corneal contact lens in this mirror group is very important.Should ensure that its refractive index can be carried out refractive index match with eye cornea and be eliminated total reflection, also will have enough corrosion resistancies (often contacting with human eye, alcohol disinfecting etc.).
Patent US5608472 achieves a kind of Large visual angle fundus imaging device of contact.This invention adopts a large amount of optical fiber arrangement to become two rings that throw light on to be placed on corneal contact lens both sides and directly throws light on to optical fundus.Illumination field of view can have been brought up to more than 120 degree by this device, but the sharp keen end face of optical fiber has the risk scratching eye cornea, and the resetting difficulty of the method is very large.
Two illumination rings are reduced to one and throw light on to human eye after being placed on corneal contact lens by patent US5822036.But the beam divergence angle due to optical fiber is general less, makes central area, optical fundus to be illuminated.Therefore, between optical fiber and corneal contact lens, also need placement annular prism for the expanded light beam angle of divergence, the end face of optical fiber directly and prism surface bond.The method design difficulty is large, and manufacturing process is complicated.
LED light source is the novel illumination light source that development in recent years goes out, and the advantages such as it is high that it has brightness, and the life-span is long, low energy consumption, instead of the conventional light source such as Halogen light, tengsten lamp gradually.CCD/CMOS technology is in recent years at the revolutionary product of optical imaging field, substantially instead of traditional film, makes optical imagery enter digital Age.The present invention is exactly a kind of fundus imaging device based on these two kinds of technological development.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of Large visual angle fundus imaging device is provided.
The present invention solves its technical problem and takes following technical scheme to realize:
A kind of Large visual angle fundus imaging device, this device comprises device case, above enclosure interior, be coaxially installed with illumination module from left to right successively, connect order object lens module, field lens module, image-forming objective lens module and imaging modules, the focusing module of adjustment imaging modules along horizontal axis movement is installed in the below of imaging modules
Wherein, described illumination module comprises round platform ring-shaped light frame, comprise round platform ring-shaped light frame, centrosymmetric multiple LED light source holddown groove is all shaped with apart from interval in the bottom outside of round platform ring-shaped light frame, LED light source is fixedly mounted with in each holddown groove, round platform ring-shaped light frame above described LED light source is made up of light guide plate inwall ring and light guide plate outer wall ring, light guide plate inwall ring and light guide plate outer wall ring fold and form ring-type light guide plate cavity, the light that LED light source sends is propagated in light guide plate cavity, corneal contact lens is fixedly mounted with at the top end opening place of round platform ring-shaped light frame, corneal contact lens is by the corneal contact lens central module covered on circular hole area that light guide plate inwall ring forms and cover the corneal contact lens annular element that the upper shed of light guide plate cavity forms on annular area and form,
Wherein, described in connect order object lens module and comprise the conical mirror be packed in the round platform ring-shaped light frame internal cavity of illumination module, conical mirror front end and corneal contact lens are fitted;
Wherein, described imaging modules comprises coaxial mounted optical filter and CCD/CMOS;
Wherein, described focusing module adopts the method for image planes movement, namely imaging modules is driven to move left and right focusing along optical axis by motor, this focusing module comprises and is packed in the bracket that motor in housing and upper surface are fixed with imaging modules, the drivewheel that motor drives its axle head to be fixedly mounted with rotates, driven pulley is fixedly mounted with below bracket, driven pulley spinning is on horizontal screw lead, drivewheel engages with driven pulley and drives driven pulley to seesaw on leading screw, thus the imaging modules realizing bracket is fixedly mounted with is along the movable focusing of optical axis.
And described corneal contact lens contacts with eye cornea, the entrance pupil of the imaging system that device is formed is between eye cornea and pupil, and apart from human eye pupil 1mm-2mm, the light beam that LED light source sends is at the vertical axle height <6mm at corneal contact lens place.
And, described in the LED light source be packed in multiple holddown groove have 14, adopt small-sized white light LEDs, covering wave band is 420nm-780nm, colour temperature 2600K-4300K, color rendering index CRI>90%, and the illumination angle of divergence of light source is more than 80 degree.
And, the inner wall surface of described light guide plate cavity carries out cuing open optical processing, cut open metal surface reflectance >80% after light, light guide plate cavity length is 20mm-30mm, light guide plate cavity thickness is 1mm-1.7mm, and light guide plate cavity slopes inwardly and is 42 degree-48 with the angle of device image-forming objective lens optical axis and spends.
And, described in meet conical mirror front end external diameter 5mm-5.5mm in order object lens module, rear end external diameter 15mm-16mm, cone angle 40 degree of-45 degree.
And be provided with dog link in the below of described motor, be fixed with brake disc in the termination, right side of dog link, brake disc extends upwardly to the rear side of imaging modules, restriction imaging modules maximum moving range backward.
And the CCD/CMOS in described imaging modules adopts USB3.0 technology as data-interface.
Advantage of the present invention and good effect are:
1, LED is used to replace optical fiber as lighting source in apparatus of the present invention, eliminate optical fiber arrangement, fix etc. debugs step, the angle of divergence of LED light source can reach more than 80 degree, the angle of divergence is expanded without the need to re-using prism, the light beam that LED light source sends, by illuminating optical fundus after hollow metal light guide plate and corneal contact lens, can form the Uniform Illumination visual field of 120 degree on human eye optical fundus.The difficulty significantly simplify the optical design of illuminator and optical manufacturing, debuging.
2, apparatus of the present invention adopt CCD/CMOS as image device, and USB3.0 technology, as data-interface, can realize the colored real-time photography of 20 frames/second to the optical fundus of human eye after mydriasis.
3, apparatus of the present invention adopt the focusing mode of image planes movement, no longer need one group of focusing lens group, simplify overall light channel structure.By pedal control step motor, drive CCD/CMOS to move forward and backward along the optical axis of optical system through change speed gear box, the functions such as focusing, grabgraf can be completed while real-time photography.
4, in order to portability and the practicality of implement device, this device has done Miniaturization Design to light source, optical system and frame for movement especially on system design, and make apparatus structure more reasonable, equipment volume reduces greatly.
Accompanying drawing explanation
Fig. 1 is the structural representation of Large visual angle fundus imaging device of the present invention;
Fig. 2 is the structural representation of Large visual angle fundus imaging device illumination module of the present invention;
Fig. 3 is the schematic diagram eliminating the veiling glare that corneal contact lens front surface is formed.
Fig. 4 is the optical schematic diagram of Large visual angle fundus imaging device of the present invention;
Fig. 5 is the structural representation of module of focusing in the present invention.
Detailed description of the invention
Be further described the invention process below in conjunction with accompanying drawing, following examples are descriptive, are not determinate, can not limit protection scope of the present invention with this.
A kind of Large visual angle fundus imaging device, as shown in Figure 1, this device comprises device case 6, above enclosure interior, be coaxially installed with illumination module 1 from left to right successively, connect order object lens module 2, field lens module 3, image-forming objective lens module 4 and imaging modules 5, the focusing module 7 of adjustment imaging modules along horizontal axis movement is installed in the below of imaging modules.
Wherein, described illumination module, as shown in Figure 2, comprise round platform ring-shaped light frame 15, centrosymmetric multiple LED light source holddown groove 8 is all shaped with apart from interval in the bottom outside of round platform ring-shaped light frame, LED light source 9 is fixedly mounted with in each holddown groove, round platform ring-shaped light frame above described LED light source is made up of the light guide plate inwall ring 14 upwards extended from light frame bottom continuous tilt and the light guide plate outer wall ring 10 that upwards extends along continuous tilt on LED light source holddown groove, light guide plate inwall ring and light guide plate outer wall ring fold and form ring-type light guide plate cavity 11, the light that LED light source sends is propagated in light guide plate cavity, corneal contact lens is fixedly mounted with on the top of round platform ring-shaped light frame, corneal contact lens is by the corneal contact lens central module 13 covered on circular hole area that light guide plate inwall ring forms and cover the corneal contact lens annular element 12 that light guide plate cavity forms on annular area and form, the connecting surface of described corneal contact lens central module and corneal contact lens annular element does the pitch-dark process of optics.
In specific embodiment of the invention, described corneal contact lens contacts with eye cornea, the entrance pupil of imaging system that this device is formed between eye cornea and pupil, apart from human eye pupil 1mm-2mm.The light beam that LED light source sends is at the vertical axle height <6mm at corneal contact lens place.
In specific embodiment of the invention, described in the LED light source be packed in multiple holddown groove have 14, adopt small-sized white light LEDs, covering wave band is 420nm-780nm, colour temperature 2600K-4300K color rendering index CRI>90%.Under the standard meeting eye-safe exposure limit, guarantee the fundus illumination obtaining enough brightness, the illumination angle of divergence of this light source, more than 80 degree, meets application needs.
In specific embodiment of the invention, the notch of described LED light source holddown groove is of a size of 1.6mmx 1.6mm, just can fixed light source.
In specific embodiment of the invention, describedly fold by light guide plate inwall ring and light guide plate outer wall ring the inner wall surface forming ring-type light guide plate cavity and carry out cuing open optical processing, cut open metal surface reflectance >80% after light, all the other all surfaces comprising light source holddown groove do the black process of photo oxidation, avoid veiling glare, the length that light guide plate cavity extends from bottom to top is 20mm-30mm, the light guide plate cavity thickness that light guide plate inwall ring and light guide plate outer wall ring fold is 1mm-1.7mm, light guide plate cavity slopes inwardly and is 42 degree-48 with the angle of system optical axis and spends.
In specific embodiment of the invention, in order to eliminate the veiling glare formed the part reflection of illumination light by corneal contact lens front surface, corneal contact lens is designed to be made up of two parts, i.e. central module and annular element.Central module is used for imaging, is a tapered lens, upper end diameter 3mm-3.5mm, lower end diameter 5mm-5.5mm.Annular element be used for illumination, external diameter 9mm, the tapered centre hole of annular element and central module measure-alike.Two parts adjacently situated surfaces do the pitch-dark process of optics, and the reflect stray light of pitch-dark rear contact lens front surface cannot enter imaging system, as shown in Figure 3.Corneal contact lens is wanted often to contact with eye cornea, and also often by cleaning disinfections such as ethanol, therefore its material will have good corrosion resistance.In addition, in order to eliminate the total reflection of eye cornea, the material require of contact lens and eye cornea carry out refractive index match, eye cornea refractive index about 1.34, therefore answer the optical material that selective refraction rate is lower, the optical plastics such as CR-39, PMMA can be selected as the material of corneal contact lens.
In specific embodiment of the invention, corneal contact lens front surface and eye cornea are fitted, radius of curvature 7.5mm-8mm, rear surface curvature 20mm-40mm, thickness 1-1.5mm, external diameter 9mm.Its focal power is negative, can expand the angle of divergence of light further, make fundus illumination more even.
As shown in Figure 4, the illumination module in the present embodiment can form the uniform illumination field of view of 120 degree on human eye optical fundus.Illumination light, by after the reflection of human eye eye ground, entering optical imaging system by pupil and corneal contact lens, successively through connecing order object lens module, field lens module and image-forming objective lens module, finally imaging on CCD/CMOS.
Wherein, as shown in Figure 4, the effect connecing order object lens module becomes a good intermediary image of quality to optical fundus, and connect order object lens module and be made up of 3-5 sheet lens, the present embodiment adopts 3 chip architectures.First lens are conical mirror 16, and be packed in the round platform ring-shaped light frame internal cavity of illumination module, front end and corneal contact lens are fitted, external diameter 5mm-5.5mm, rear end external diameter 15mm-16mm, cone angle 40 degree of-45 degree.It should be noted that front end external diameter can not be excessive, because excessive external diameter can cause the vertical axle excessive height of illuminating bundle, make it cannot illuminate central area, optical fundus.
Second lens is simple lens 17, be mainly used in light deflection, namely the main focal power of this battery of lens is born, because light deflection mainly occurs on the second side, therefore its thickness determines the overall dimensions of whole optical imaging system, in order to miniaturization of the apparatus, lighting, its thickness is no more than 10mm.
3rd lens are cemented doublet 18, are mainly used in color difference eliminating.
Wherein, as shown in Figure 4, field lens module is mainly used in flat field correction, be made up of 1-3 sheet lens, the present embodiment adopts 2 chip architectures, and first lens are biconvex lens 19, be mainly used in pupil image, namely ensure the object-image relation of system entrance pupil and aperture diaphragm, second lens is meniscus lens 20, is mainly used in correcting the curvature of field.
Wherein, as shown in Figure 4, image-forming objective lens module is mainly used in carrying out secondary imaging to the intermediary image on optical fundus, and eliminate a large amount of aberrations, image quality is met design requirement, can be made up of 3-6 sheet lens, the implementation case uses 4 double gauss structures, wherein 2 slices comprise 1 for anti-convention gummed, the wave band of below 450nm and more than 750nm of the optical filter filtering in imaging modules for cemented doublet, make image color more truly close.
Wherein, described imaging modules comprises after coaxial mounted optical filter 21 and CCD/CMOS22, CCD/CMOS receive optical signal, sensitive chip on it is by after opto-electronic conversion, the Signal transmissions formed to display chip, then through display chip process, forms picture signal.This picture signal is transferred in computer by USB3.0 interface, finally forms real-time eye fundus image over the display.
Wherein, as shown in Fig. 1 or 5, described focusing module is used for realizing the movement of image planes, namely drive imaging modules along the movable focusing of optical axis by motor, and whether eye fundus image on observation display clear, when eye fundus image do enough clear after, capture image and preserve in a computer.This focusing module comprises and is packed in the bracket 23 that motor 24 in housing and upper surface are fixed with imaging modules, the drivewheel 25 that motor drives its axle head to be fixedly mounted with rotates, driven pulley 29 is fixedly mounted with below bracket, driven pulley spinning is on horizontal screw lead 26, drivewheel engages with driven pulley and drives driven pulley to seesaw on leading screw, thus the imaging modules realizing bracket is fixedly mounted with is along the movable focusing of optical axis.
Focusing and grabgraf can have been controlled by pedal, also can be completed by supporting software control.In addition software can also arrange the illumination light systematic parameter such as dark and browse photo, enlarged photograph, arranges the associative operations such as case.
In specific embodiment of the invention, be provided with dog link 27 in the below of described motor, be fixed with brake disc 28 in the termination, right side of dog link, brake disc extends upwardly to the rear side of imaging modules, restriction imaging modules maximum moving range backward.
Claims (7)
1. a Large visual angle fundus imaging device, it is characterized in that: this device comprises device case, above enclosure interior, be coaxially installed with illumination module from left to right successively, connect order object lens module, field lens module, image-forming objective lens module and imaging modules, the focusing module of adjustment imaging modules along horizontal axis movement is installed in the below of imaging modules
Wherein, described illumination module comprises round platform ring-shaped light frame, comprise round platform ring-shaped light frame, centrosymmetric multiple LED light source holddown groove is all shaped with apart from interval in the bottom outside of round platform ring-shaped light frame, LED light source is fixedly mounted with in each holddown groove, round platform ring-shaped light frame above described LED light source is made up of light guide plate inwall ring and light guide plate outer wall ring, light guide plate inwall ring and light guide plate outer wall ring fold and form ring-type light guide plate cavity, the light that LED light source sends is propagated in light guide plate cavity, corneal contact lens is fixedly mounted with at the top end opening place of round platform ring-shaped light frame, corneal contact lens is by the corneal contact lens central module covered on circular hole area that light guide plate inwall ring forms and cover the corneal contact lens annular element that the upper shed of light guide plate cavity forms on annular area and form,
Wherein, described in connect order object lens module and comprise the conical mirror be packed in the round platform ring-shaped light frame internal cavity of illumination module, conical mirror front end and corneal contact lens are fitted;
Wherein, described imaging modules comprises coaxial mounted optical filter and CCD/CMOS;
Wherein, described focusing module adopts the method for image planes movement, namely drive imaging modules along the movable focusing of optical axis by motor, this focusing module comprises and is packed in the bracket that motor in housing and upper surface are fixed with imaging modules, the drivewheel that motor drives its axle head to be fixedly mounted with rotates, driven pulley is fixedly mounted with below bracket, driven pulley spinning is on horizontal screw lead, drivewheel engages with driven pulley and drives driven pulley to seesaw on leading screw, thus the imaging modules realizing bracket is fixedly mounted with is along the movable focusing of optical axis.
2. the Large visual angle illuminator for fundus imaging according to claim 1, it is characterized in that: described corneal contact lens contacts with eye cornea, the entrance pupil of the imaging system that device is formed is between eye cornea and pupil, apart from human eye pupil 1mm-2mm, the light beam that LED light source sends is at the vertical axle height <6mm at corneal contact lens place.
3. the Large visual angle illuminator for fundus imaging according to claim 1, it is characterized in that: described in the LED light source be packed in multiple holddown groove have 14, adopt small-sized white light LEDs, covering wave band is 420nm-780nm, colour temperature 2600K-4300K, color rendering index CRI>90%, the illumination angle of divergence of light source is more than 80 degree.
4. the Large visual angle illuminator for fundus imaging according to claim 1, it is characterized in that: the inner wall surface of described light guide plate cavity carries out cuing open optical processing, cut open metal surface reflectance >80% after light, light guide plate cavity length is 20mm-30mm, light guide plate cavity thickness is 1mm-1.7mm, and light guide plate cavity slopes inwardly and is 42 degree-48 with the angle of device image-forming objective lens optical axis and spends.
5. Large visual angle fundus imaging device according to claim 1, is characterized in that: described in meet conical mirror front end external diameter 5mm-5.5mm in order object lens module, rear end external diameter 15mm-16mm, cone angle 40 degree of-45 degree.
6. Large visual angle fundus imaging device according to claim 1, it is characterized in that: in the below of described motor, dog link is installed, be fixed with brake disc in the termination, right side of dog link, brake disc extends upwardly to the rear side of imaging modules, restriction imaging modules maximum moving range backward.
7. Large visual angle fundus imaging device according to claim 1, is characterized in that: the CCD/CMOS in described imaging modules adopts USB3.0 technology as data-interface.
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| WO2019033334A1 (en) * | 2017-08-17 | 2019-02-21 | Xinova, LLC | Contact lenses with bifocal characteristics |
| US11793674B2 (en) | 2017-08-17 | 2023-10-24 | Lutronic Vision Inc. | Contact lenses with bifocal characteristics |
| CN113507879A (en) * | 2018-10-13 | 2021-10-15 | 普瑞文塔医疗公司 | Illuminated contact lenses and systems for improved ocular diagnosis, disease management and surgery |
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| CN113133740A (en) * | 2021-05-21 | 2021-07-20 | 苏州依视禾医疗科技有限公司 | Large-depth-of-field eye imaging equipment |
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