CN104245097A - Hollow fiber membrane module - Google Patents
Hollow fiber membrane module Download PDFInfo
- Publication number
- CN104245097A CN104245097A CN201380015302.XA CN201380015302A CN104245097A CN 104245097 A CN104245097 A CN 104245097A CN 201380015302 A CN201380015302 A CN 201380015302A CN 104245097 A CN104245097 A CN 104245097A
- Authority
- CN
- China
- Prior art keywords
- hollow fiber
- body shell
- head
- fixed bed
- ultrasonic wave
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012510 hollow fiber Substances 0.000 title claims abstract description 85
- 239000012528 membrane Substances 0.000 title claims abstract description 59
- 239000007788 liquid Substances 0.000 claims abstract description 21
- 238000013461 design Methods 0.000 claims abstract description 10
- 239000011248 coating agent Substances 0.000 claims description 67
- 238000000576 coating method Methods 0.000 claims description 67
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- 229920005989 resin Polymers 0.000 claims description 28
- 239000011347 resin Substances 0.000 claims description 28
- 241000538562 Banjos Species 0.000 claims description 23
- 239000000835 fiber Substances 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 9
- 238000007711 solidification Methods 0.000 claims description 3
- 230000008023 solidification Effects 0.000 claims description 3
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- 238000000151 deposition Methods 0.000 description 34
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- -1 polypropylene Polymers 0.000 description 14
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- 230000014759 maintenance of location Effects 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 230000001194 anti-hemostatic effect Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
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- 239000000155 melt Substances 0.000 description 1
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- 229920000728 polyester Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
-
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- B01D63/02—Hollow fibre modules
- B01D63/021—Manufacturing thereof
- B01D63/0233—Manufacturing thereof forming the bundle
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D63/02—Hollow fibre modules
- B01D63/031—Two or more types of hollow fibres within one bundle or within one potting or tube-sheet
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- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
- B29C65/08—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using ultrasonic vibrations
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- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
- B29C66/114—Single butt joints
- B29C66/1142—Single butt to butt joints
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
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- B29C66/122—Joint cross-sections combining only two joint-segments, i.e. one of the parts to be joined comprising only two joint-segments in the joint cross-section
- B29C66/1222—Joint cross-sections combining only two joint-segments, i.e. one of the parts to be joined comprising only two joint-segments in the joint cross-section comprising at least a lapped joint-segment
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- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
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- B29C66/13—Single flanged joints; Fin-type joints; Single hem joints; Edge joints; Interpenetrating fingered joints; Other specific particular designs of joint cross-sections not provided for in groups B29C66/11 - B29C66/12
- B29C66/131—Single flanged joints, i.e. one of the parts to be joined being rigid and flanged in the joint area
- B29C66/1312—Single flange to flange joints, the parts to be joined being rigid
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- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
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- B29C66/01—General aspects dealing with the joint area or with the area to be joined
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- B29C66/232—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being multiple and parallel or being in the form of tessellations said joint lines being multiple and parallel, i.e. the joint being formed by several parallel joint lines
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- B29C66/05—Particular design of joint configurations
- B29C66/302—Particular design of joint configurations the area to be joined comprising melt initiators
- B29C66/3022—Particular design of joint configurations the area to be joined comprising melt initiators said melt initiators being integral with at least one of the parts to be joined
- B29C66/30223—Particular design of joint configurations the area to be joined comprising melt initiators said melt initiators being integral with at least one of the parts to be joined said melt initiators being rib-like
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- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/32—Measures for keeping the burr form under control; Avoiding burr formation; Shaping the burr
- B29C66/322—Providing cavities in the joined article to collect the burr
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
- B29C66/543—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining more than two hollow-preforms to form said hollow articles
- B29C66/5432—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining more than two hollow-preforms to form said hollow articles joining hollow covers and hollow bottoms to open ends of container bodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
- B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
- B29C66/739—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset
- B29C66/7392—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic
- B29C66/73921—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic characterised by the materials of both parts being thermoplastics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
- B29C66/832—Reciprocating joining or pressing tools
- B29C66/8322—Joining or pressing tools reciprocating along one axis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/04—Specific sealing means
- B01D2313/041—Gaskets or O-rings
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D2313/21—Specific headers, end caps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
- B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
- B29C66/731—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the intensive physical properties of the material of the parts to be joined
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29L2031/14—Filters
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Manufacturing & Machinery (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Water Supply & Treatment (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- External Artificial Organs (AREA)
Abstract
Provided is a hollow fiber membrane module that has excellent liquid tightness, high bonding strength in a welding portion, and can be manufactured efficiently. The present invention comprises a hollow fiber membrane bundle (4), a main body case (3) that receives the hollow fiber membrane bundle (4), a membrane fixing layer (5) that fixes the hollow fiber membrane bundle (4) to an inner wall of an end portion of the main body case, and headers (8) and (9) that are attached to a case opening end portion and have an inlet (6) or an outlet (7) for a treatment target liquid. The headers (8) and (9) and the main body case (3) are ultrasonically welded in at least two areas over the entire circumference. A share joint is used as joint design by which a side surface of an outer circumference of the main body case and inner side surfaces of the headers are ultrasonically welded over the entire circumference. A butt joint is used as joint design by which a cross section of the main body case and the inner side surfaces of the headers are ultrasonically welded over the entire circumference.
Description
Technical field
The present invention relates to hollow fiber film assembly, be particularly applicable to the hollow fiber film assembly of blood purification, blood separator etc.
Background technology
In the past well-known, in order to carry out the purification of blood, such as, carry out the dialysis of blood and use the hollow fiber film assembly possessing hollow-fibre membrane.This hollow fiber film assembly has: cylindric body shell, possesses treatment fluid ingress port at the outer peripheral face of one end of this body shell, possess treatment fluid outlet port at the outer peripheral face of the other end; Hollow fiber membrane bundle, inserts in aforementioned body shell in this hollow fiber membrane bundle; Film fixed bed, this film fixed bed by above-mentioned hollow fiber membrane bundle at end winding support in body shell inwall, be fixed with head at the open end of body shell.When for haemodialysis, dislysate (treatment fluid) is imported from treatment fluid ingress port and derives from treatment fluid outlet port, thus make it circulate in body shell, and make blood (liquid to be treated) from the blood of head import port by and circulate to carry out haemodialysis in hollow-fibre membrane towards derivation port.
In such dialysis procedure, in order to not make the liquid to be treated (blood) circulated in hollow fiber film assembly spill from the junction surface of head and body shell, need to carry out fluid-tight seal to hollow fiber film assembly.Therefore the method using ultrasonic wave coating to be engaged with body shell by head is extensively carried out.The joint method of ultrasonic wave coating is that use instrument flared portion applies pressure to the end face of head, make being abutted by melt-coating part and applying ultrasonic wave and vibrate by deposition part and cylindric body shell of head, thus to by melt-coating part transmitting vibrations, make to be generated heat each other by melt-coating part, melting thus the method engaged, even need air-tightness, fluid-tight container also can stably seal, be therefore widely used.
Such as, patent document 1 discloses following joint and adds strong method: after main body container and head are carried out ultrasonic wave coating between main body container peripheral part and this inner portion fusion penetration portion, use the flared portion of front end tapered shape, by the side of this main body container of the center side of above-mentioned main body container, ultrasonic wave coating is carried out to this head from than above-mentioned fusion penetration portion.But the disclosed joint of patent document 1 adds strong method to be needed to carry out twice ultrasonic wave coating, and therefore productivity ratio is low, not talkative is engage efficiently to add strong method.
In addition, as shown in Figure 7, method disclosed in patent document 1 is the method for in 33,34 these two positions, main body container 31 and head 32 being carried out to ultrasonic wave coating, even if but the ultrasonic wave coating portion 33 and 34 of two positions is possessed in the side of main body container 31, the blood be imported into from the blood importing port of head 32 under elevated pressure also cannot be suppressed to be immersed in gap 36 less between head 32 and film fixed bed 35.
Patent document 1: Japan Patent No. 4842419 description
Summary of the invention
The present invention completes in view of the above-mentioned shortcoming existed in prior art, and object is to provide a kind of hollow fiber film assembly, and this hollow fiber film assembly possesses the high and structure that can manufacture efficiently of fluid tight bond strength that is excellent, deposition part.
To achieve these goals, the hollow fiber film assembly of the present inventor, possess: hollow fiber membrane bundle, receive the body shell of described hollow fiber membrane bundle, for described hollow fiber membrane bundle being fixed on the film fixed bed of the inwall of body shell end, and be installed on shell opener end there is the introducing port of liquid to be treated or the head of export mouth, carry out ultrasonic wave coating in the region described head and described body shell being spread all at least two positions of complete cycle thus form liquid-tight structure, the feature of described hollow fiber film assembly is, shared joints is used to spread all over as to the side of body shell periphery and the medial surface of head the joint design that complete cycle carries out ultrasonic wave coating, banjo fixing butt jointing is used to spread all over as to the end face of body shell and the medial surface of head the joint design that complete cycle carries out ultrasonic wave coating.
In addition, at this, ultrasonic wave coating refers to certainly: under connector portions does not exist the bad state such as bubble, crack, carry out deposition, and the inner peripheral surface becoming head spreads all over the state that complete cycle contacts with film fixed bed.
Be preferably, it is 0.3 ~ 0.9mm that the weld width of described shared joints is multiplied by the sectional area highly obtained
2, more preferably 0.4 ~ 0.7mm
2.If be less than 0.3mm
2, then the enough intensity for engaging cannot be obtained.On the other hand, if more than 0.9mm
2, then melting is difficult in order to the energy needed for melting increases.In addition, as the width of shared joints, be preferably more than 0.25mm.If be less than 0.25mm, then cause the shared joints of head to be opened towards peripheral direction because of elastic deformation, make head and body shell overlapping hardly, therefore in fact not by deposition.
Be preferably, the most inner circumferential of described banjo fixing butt jointing and the inner peripheral surface distance in the horizontal direction of head are 0.5 ~ 2.0mm, more preferably 1.0 ~ 2.0mm.The shorter then banjo fixing butt jointing of distance in this horizontal direction fluid tight higher, but consider that technical restriction at least also needs 0.5mm.But, if be longer than 2.0mm, then cannot expect the fluid-tight raising of banjo fixing butt jointing.
Preferably, the leg-of-mutton area that the half that the width of the guider of described banjo fixing butt jointing is multiplied by height obtains is 0.05 ~ 0.35mm
2, more preferably 0.1 ~ 0.2mm
2.This leg-of-mutton area refers to the sectional area of the connector portions of guider.If this area is less than 0.05mm
2, then the melting of head and body shell is insufficient, only guider is pressed on shell end face and cannot obtain the enough intensity needed for joint.On the other hand, if more than 0.35mm
2, then the energy needed for melting increases, and guider is difficult to melting.In addition, if the toe angle of guider (θ 1 of Fig. 2 (b)) is 40 ~ 70 degree, then stress concentrates on front end and is easy to melting, is therefore preferred.
Be preferably, in the inner circumferential side of banjo fixing butt jointing and outer circumferential side both sides, there is resin reservoir.Accept the resin of melting in this resin reservoir, therefore can carry out ultrasonic wave coating well.
A kind of manufacture method of hollow fiber film assembly, it is the method manufacturing hollow fiber film assembly, described hollow fiber film assembly possesses: hollow fiber membrane bundle, receive the body shell of described hollow fiber membrane bundle, for described hollow fiber membrane bundle being fixed on the film fixed bed of the inwall of body shell end, and be installed on shell opener end there is the introducing port of liquid to be treated or the head of export mouth, carry out ultrasonic wave coating in the region described head and described body shell being spread all at least two positions of complete cycle simultaneously, the feature of the manufacture method of described hollow fiber film assembly is, spreading all over complete cycle to the side of body shell periphery and the medial surface of head utilizes shared joints to carry out ultrasonic wave coating, spreading all over complete cycle to the end face of body shell and the medial surface of head utilizes banjo fixing butt jointing to carry out ultrasonic wave coating.
A kind of hollow fiber film assembly, the many hollow-fibre membranes be made up of hollow-fibre membrane polymer are carried out to harness and are inserted into body shell, after film fixed bed note type block is installed on described body shell end, inject film fixed bed polymer to body shell end and form film fixed bed, thus hollow fiber membrane bundle is fixed on body shell, after described film fixed bed solidification, in the mode of the both ends of the surface making hollow fiber membrane bundle opening toward the outer side by a film fixed bed excision part, ultrasonic wave coating is carried out simultaneously to manufacture hollow fiber film assembly in the region that spread all at least two positions of complete cycle to the body shell after a part of film fixed bed of excision and head, the feature of described hollow fiber film assembly is, inner portion face and the end contact of film fixed bed do not excised.
According to the present invention, can provide and possess the hollow fiber film assembly of structure that fluid tight bond strength that is excellent, deposition part is high, can manufacture efficiently.
Accompanying drawing explanation
Fig. 1 is the sectional view of the embodiment illustrating hollow fiber film assembly of the present invention.
Fig. 2 (a) be represent main portions of the present invention by the figure after the partial enlargement of Fig. 1, Fig. 2 (b) is the figure after the part surrounded with circle in Fig. 2 (a) being amplified, and Fig. 2 (c) illustrates the figure being arranged on the back taper portion of the film fixed bed contacted with the medial surface of head.
Fig. 3 is the diagrammatic cross-sectional view of the example representing shared joints.
Fig. 4 is the diagrammatic cross-sectional view of the example representing banjo fixing butt jointing.
Fig. 5 is the schematic side view illustrating ultrasonic wave coating apparatus.
Fig. 6 represents the sectional view being provided with the state of block at the end face of body shell.
Fig. 7 represents the sectional view adding an example of the hollow fiber film assembly of strong method for illustration of the disclosed joint of patent document 1.
Detailed description of the invention
As the device can applying hollow fiber film assembly of the present invention, can enumerate with the hollow fiber membrane-type artificial kidney medical assembly such as haemodialyser, plasma separator, cascadeflow, blood filter, plasma fraction absorber, artificial lung and endotoxin removal filter that is representative, be filled with the absorbent module of sorbing material and the assembly etc. of filter.
With reference to the accompanying drawings, an embodiment of hollow fiber film assembly of the present invention is described.
Fig. 1 is the figure of the embodiment representing situation about being used as haemodialyser by hollow fiber film assembly of the present invention, and preferred embodiment or illustration are not limited to this situation.In FIG, hollow fiber film assembly has: cylindric body shell 3, possesses the ingress port 1 for the treatment of fluid, possess the outlet port 2 for the treatment of fluid near another end near an end of its length direction; Hollow fiber membrane bundle 4, the interior multiple hollow-fibre membranes inserting in this body shell 3 pull together and are formed by one direction; Film fixed bed 5, its by above-mentioned hollow fiber membrane bundle 4 at the inwall of each end winding support in body shell 3.In addition, the head 9 as lid of the head 8 as lid possessing the ingress port 6 of liquid to be treated and blood and the outlet port 7 possessing liquid to be treated and blood, is fixed on the end of body shell 3 by deposition by ultrasonic wave coating portion 10.
The material of body shell and head does not limit, and can use the plastics such as polypropylene, polyethylene, polyester, polytetrafluoroethylene (PTFE), Merlon, acrylonitrile-butadiene-styrene (ABS) (ABS).Heat-curing resin is after molecular configuration is with three-dimensional one-shot forming, even if heating also can not melting, on the other hand, thermoplastic resin is chain macromolecule, has the characteristic of shaping rear heating then melting, so in the present invention, preferably uses thermoplastic resin.In addition, thermoplastic resin is divided into amorphous resin and hemicrystalline resin, although amorphous resin is chain high molecule bonding, but a part for the chain high molecule bonding of hemicrystalline resin is in the molecules align of rule, so amorphous resin more easily carries out ultrasonic wave coating than hemicrystalline resin (such as, polyamide, polyethylene, polypropylene, polyacetals etc.).
As the material of hollow fiber membrane bundle, such as, can enumerate cellulose, cellulose derivative, polymethyl methacrylate (PMMA), polypropylene, polysulfones etc.But, when the hydrophobic polymer only utilizing polysulfones such makes the hollow-fibre membrane for dialyse etc., be not only difficult to control aperture, sometimes also make the blood constituent attachments such as blood platelet due to hydrophobicity, blood adaptability exists shortcoming.Therefore use together with hydrophilic macromolecule, thus can solve the problem.Specifically, in advance hydrophilic macromolecule is mixed in masking stoste as pore former, make the hydrophilic macromolecule of a part depart from and after forming hole, utilize remaining hydrophilic macromolecule to make polymer surfaces hydrophiling etc. simultaneously, thus hollow-fibre membrane can be it can be used as to use.
As above-mentioned hydrophilic macromolecule, such as, can use polyethylene glycol, polyvinyl alcohol, carboxymethyl cellulose, PVP etc., also can be used alone, can also be used in combination.Become more readily available from the viewpoint of industrial and have clinical effectiveness, blood adaptability height, preferably polyethylene pyrrolidones.
In addition, the material as film fixed bed can enumerate the macromolecular materials such as polyurethane, silicone, epoxy resin, preferably can list the polymer binder of above-mentioned two kinds of mixing cured types of liquid, can pass through centrifugal forming (embedding) etc. and manufacture.
The method utilizing above-mentioned material to manufacture hollow fiber film assembly is described based on Fig. 1.Harness is carried out to the many hollow-fibre membranes be made up of the hollow-fibre membrane polymer selected from above-mentioned material, and be inserted into by the shaping body shell 3 such as known injection molding method, by film fixed bed 5 note type with block 26 (such as, with reference to Fig. 6) be installed on the end of body shell 3 after, the film fixed bed polymer selected from above-mentioned material is injected into the end of body shell 3, form film fixed bed 5, thus hollow fiber membrane bundle 4 is fixed on body shell 3.After film fixed bed 5 solidifies, in the mode of the both ends of the surface making hollow fiber membrane bundle 4 opening toward the outer side, film fixed bed 5 is excised a part, use ultrasonic wave coating by fluid tight for the head 8 and 9 shaping by known injection molding method etc. the both ends being arranged on the body shell 3 after a part of film fixed bed of excision, manufacture hollow fiber film assembly thus.
Key character of the present invention is, forming liquid-tight structure, based on Fig. 2 (a), key character of the present invention being described by carrying out ultrasonic wave coating in the region that head and body shell spread all at least two positions of complete cycle.In the following description, the situation that body shell 3 and head 9 are carried out ultrasonic wave coating is described, but also identical when carrying out ultrasonic wave coating to body shell 3 and head 8, so omit repeat specification.
As shown in Fig. 2 (a), body shell 3 and head 9, become liquid-tight structure by the ultrasonic wave coating portion 10a be made up of shared joints that spreads all over complete cycle and the ultrasonic wave coating portion 10b that is made up of banjo fixing butt jointing.In addition, this ultrasonic wave coating portion 10a and ultrasonic wave coating portion 10b can be formed by ultrasonic wave coating simultaneously, according to the present invention, can manufacture hollow fiber film assembly efficiently.11 and 12 is resin reservoirs, and this resin reservoir can accept the resin of the melting by ultrasonic wave coating, therefore, it is possible to carry out ultrasonic wave coating smoothly.For the capacity of resin reservoir 11,12, because suitable value is different from the shape of banjo fixing butt jointing and shared joints, therefore the capacity of resin reservoir 11,12 does not do particular provisions, but suitably determines in the mode that can store from the molten resin amount of two joints.
When being obtained liquid-tight structure by ultrasonic wave coating, joint design is extremely important.This joint design exists with lower contact: the oblique scarf joint realizing the contact of face completely formed by inclined-plane; Obtained the impact joint of consistent heat generation in connector portions by the face contact of direction of vibration; , be therefore difficult in deposition face produce bubble and fluid tight, that air-tightness is excellent shared joints relative to flaring extensional vibration towards close with contact surface direction of vibration equidirectional as above-mentioned oblique scarf joint and the joint of the centre of impact joint as shown in Figure 3; Adopt the one of the joint design using energy drag device as shown in Figure 4, and make concentration of energy in the leg-of-mutton projection being called as guider, and be warmed up to resin melt temperature in very short time, thus the banjo fixing butt jointing etc. of efficient deposition can be carried out.
In figure 3, H1 represents deposition amount, and C represents the gap of lifting workpiece, and I represents interference size, and in the diagram, W represents the width of guider, and H2 represents the height of guider.In addition, banjo fixing butt jointing has the advantages such as shape is single, the space constraints at junction surface is smaller, but in the extensional vibration deposition method of banjo fixing butt jointing, cannot produce powerful ultrasonic energy.To this, if there is not above-mentioned unfavorable condition and adopt shared joints as the joint design of hemicrystalline resin needing powerful ultrasonic energy in shared joints, then can obtain higher cladding intensity and fluid tight.The present invention has shared joints and the banjo fixing butt jointing of such advantage by adopting simultaneously, can possess higher bond strength and fabulous fluid tight thus.
In Fig. 2 (b), the width (W2) of shared joints is preferably more than 0.25mm.In addition, for the foregoing reasons, be multiplied by by the width (W2) of shared joints the sectional area that highly (L2) obtains and be preferably 0.3 ~ 0.9mm
2, be more preferably 0.4 ~ 0.9mm
2.
In Fig. 2 (a), for the foregoing reasons, the distance (L) of the most inner circumferential of the ultrasonic wave coating portion 10b be made up of banjo fixing butt jointing and the horizontal direction of head inner peripheral surface is preferably 0.5 ~ 2.0mm.
In addition, in the diagram, for the foregoing reasons, the half of height (H2) is multiplied by by the width (W) of guider and the leg-of-mutton area (sectional area of the connector portions of banjo fixing butt jointing) that obtains is preferably 0.05 ~ 0.35mm
2.
In addition, hollow fiber film assembly of the present invention, the many hollow-fibre membranes be made up of hollow-fibre membrane polymer are carried out to harness and they are inserted in body shell, after film fixed bed note type block 26 is installed on aforementioned body shell end, film fixed bed polymer is injected body shell end and forms film fixed bed, thus hollow fiber membrane bundle is fixed on body shell, after above-mentioned film fixed bed solidification, in the mode of the both ends of the surface making hollow fiber membrane bundle opening toward the outer side by a film fixed bed excision part, and spread all in the region of at least two positions of complete cycle to the body shell after a part of film fixed bed of excision and head, carry out ultrasonic wave coating to manufacture simultaneously.In this manufacturing process, as shown in Fig. 2 (a), for the end face of the film fixed bed 5 of the part of multiple hollow-fibre membrane 4a insertion, to make the mode of the both ends of the surface of hollow fiber membrane bundle 4 opening toward the outer side cut, so the end face of the film fixed bed 5 of this cut-out, than not having, the end face of cut film fixed bed 5 is slightly thick.Therefore, as shown in Fig. 2 (a), if the medial surface of head 9 possesses the end contact of the film fixed bed 5 of flatness with not excising, then can improve fluid tight further.As the index of the flatness of film fixed bed 5, the center line average roughness Ra on surface is preferably less than 50 μm, is more preferably less than 20 μm.In addition, if the end face of film fixed bed 5 is the shape risen and fallen, then between the inner peripheral surface of contacted head 9, produces gap and cause blood to invade.It is less than 100 μm that the ladder difference of the film fixed bed 5 therefore contacted with the inner peripheral surface of head 9 preferably spreads all over complete cycle.In addition, if form the back taper portion expanded towards outside gradually from the outer circumferential side of radial direction towards central side at the film fixed bed 5 of the scope contacted with the medial surface of head 9, then head 9 increases with the reaction force of film fixed bed 5, and easy further anti-Hemostatic Oral Liquid immerses.The angle (θ (△ H/R) of Fig. 2 (c)) in preferred back taper portion is 1 ~ 10 ゜, is more preferably 2 ~ 6 ゜.
As mentioned above, in hollow fiber film assembly of the present invention, the shared joints using versatility excellent in the region that head and body shell spread all at least two positions of complete cycle and efficient banjo fixing butt jointing carry out ultrasonic wave coating, thus can improve fluid tight, improve the bond strength of deposition part.As shown in Figure 7, in the joint method of existing head and body shell, in order to stop the gap 36 between blood immersion head 32 and film fixed bed 35, and the endless elastomeric 37 inserted in head 32 side of this part as seal, but hollow fiber film assembly of the present invention is fluid tight excellent, so can above-mentioned endless elastomeric 37.
The ultrasonic wave coating apparatus that can use in the present invention does not limit, but optimized frequency is the device of 15kHz ~ 60kHz.If frequency of utilization is the device of about 15kHz ~ 40kHz in addition, then vibrates and be easily passed to by melt-coating part, so well deposition can be transmitted.Such as, the device shown in Fig. 5 can be exemplified.In Figure 5, oscillator 22 receives the signal in oscillator 21 generation and vibrates, and utilizes flared portion 23 to vibrate the amplitude being amplified to regulation.Utilize actuator 24 that flared portion 23 and head 8 are pushed, mutually by the ultrasonic wave coating portion 10 of ultrasonic wave vibration passing to Fig. 1 under the state of pressurizeing to the end face of head.
Head by melt-coating part due to the pressurization of flared portion 23 with being collided by melt-coating part of body shell 3.And then pressurize while apply ultrasonic wave vibration, thus generated heat rapidly by melt-coating part interface each other and start melting.The resin of melting melts out the space of periphery.In addition, by applying pressure and ultrasonic wave vibration, thus fusing is continued by melt-coating part.After reached desired through welding amount by melt-coating part, if stop ultrasonic wave vibration, then cooled by melt-coating part, head 8 and body shell 3 are fixed.
Stressed suitable value is because of the material, different by the shape of melt-coating part of head and body shell, therefore particular provisions are not done, but general when though the complete cycle that diameter is the cylindrical vessel of 60mm carries out deposition, in most cases apply the pressure of about 0.2 ~ 0.6MPa.In addition, under the material of head is polypropylene, poly situation, if pressure is excessive, then head produces distortion, or is generated heat by beyond melt-coating part, so under low pressure carry out deposition can obtain good deposition result compared with other materials.
In addition, in Figure 5, hollow fiber film assembly is held in plummer 25.In order to Transmit evenly vibration, as this Fig. 5, utilize plummer 25 to keep hollow fiber film assembly, thus deposition result can be made to stablize.For the setting direction of cladding machine, when flared portion is arranged on than body shell on the lower, flared portion is arranged on and more inferiorly than body shell situation by the top do not do particular provisions, but in either case, preferably make head consistent with the axiality of body shell, thus make deposition in stable condition.
[embodiment]
Below embodiments of the invention are described, but the invention is not restricted to following embodiment, can various correction, change be carried out in the scope not departing from technical scope of the present invention.
(embodiment 1)
Be 200 μm by internal diameter, thickness is the hollow fiber membrane bundle of 9200 hollow-fibre membrane harnesses of the polysulfones of 40 μm, with make two ends from body shell end respectively the mode of outstanding more than 7mm be inserted into the polypropylene shell (body shell that total length is 285mm, body part internal diameter is 34.8mm, inner end diameter is 44.2mm, outer end diameter is 48.2mm, Reference numeral 3 with reference to Fig. 1), end face at these two ends exports the carbon dioxide laser for 80W with the patterned illumination of regulation, is sealed by the hollow bulb of hollow-fibre membrane end face.Then, block (Reference numeral 26 with reference to Fig. 6) is installed at the two ends of body shell, with the position of the half of body shell total length for rotary middle spindle, as radius of turn, body shell is rotated the half of total length, utilize consequent centrifugal force, make the curable urethane resin injected from the ingress port (Reference numeral 1 with reference to Fig. 1) for the treatment of fluid and the outlet port (Reference numeral 2 with reference to Fig. 1) for the treatment of fluid, form film fixed bed at the two ends of body shell, hollow fiber membrane bundle and body shell are fixed.The diameter of film fixed bed in shell end is 44.2mm, and from shell end 0.1mm laterally, diameter linearity undergauge is 41mm, the maximum extension 7.4mm towards outside further from this position.But the overhang existed near the inner peripheral surface of body shell end from shell end is laterally less than the film fixed bed part of 0.5mm.In the end from body shell, the position of 0.5mm laterally, cuts off such film fixed bed in the mode orthogonal with the axis of body shell, forms film fixed bed end face and makes hollow-fibre membrane opening.Then, be 20kHz in frequency, under pressure is 0.35MPa, the deposition time is 0.7 second, the retention time is the condition of 1.0 seconds, ultrasonic wave coating carried out to the head (Reference numeral 8,9 with reference to Fig. 1) of polypropylene and body shell.Wherein, the non-sectility face in the outer part, face that the ratio inner peripheral surface of head being pressed on film fixed bed end face cuts off, the film namely formed by block inner surface are fixed aspect, and are carried out ultrasonic wave coating.The fluctuating produced when considering owing to cutting off, if head inner peripheral surface is pressed on sectility face, local produces gap, so head inner peripheral surface is pressed on the film formed by block inner surface to fix aspect, reduce gap thus, thus ultrasonic wave coating can be carried out with the state be more close to.
In addition, in this embodiment, as shown in Figure 6, the part near the periphery of end face is used not to be projected into the block 26 of the such shape of 0.5mm laterally from body shell end, even if so in the end from body shell 3 in the outer part 0.5mm position cut off, also can not be cut off near above-mentioned periphery, the film formed by block inner surface is fixed aspect former state and is retained.
After the intermediate products of deposition are disintegrated, the inner peripheral surface diameter D0 of head (Reference numeral 9 with reference to Fig. 2 (a)) is 41.5mm, the point diameter D1 of the first connector portions (the Reference numeral 10b with reference to Fig. 2 (a)) is 44.6mm, deposition degree of depth L1 is 0.5mm, deposition width W 1 is 0.5mm, the internal diameter D2 of the second connector portions (the Reference numeral 10a with reference to Fig. 2 (a)) is 47.4mm, deposition degree of depth L2 is 1.2mm, deposition width W 2 is 0.4mm, the width of the first resin reservoir (Reference numeral 12 with reference to Fig. 2 (a)) is 0.5mm, be highly 1mm, the width of the second resin reservoir (Reference numeral 11 with reference to Fig. 2 (a)) is 0.9mm, be highly 1mm (with reference to Fig. 2 (b)).The width of the joint of the second connector portions is 0.4mm, and the sectional area of the second connector portions is 0.48mm
2, the horizontal range of the most inner circumferential of the first joint and the inner peripheral surface of head is 1.55mm, and the sectional area of the first connector portions is 0.125mm
2.Finally, install respectively and bale packing key with outlet port (Reference numeral 2 with reference to Fig. 1) at the ingress port (Reference numeral 6 with reference to Fig. 1) of liquid to be treated and the ingress port (Reference numeral 1 with reference to Fig. 1) of outlet port (Reference numeral 7 with reference to Fig. 1), treatment fluid, carry out gamma-rays sterilization, completing effective film area is 1.5m
2blood processor.
Dislysate is filled, at the liquid that the filling of liquid to be treated side mixes according to the ratio that prepared Chinese ink and normal saline solution are 1:10 in the treatment fluid side of the blood processor manufactured like this.Then, at the ingress port (Reference numeral 1 with reference to Fig. 1) for the treatment of fluid, the outlet port (Reference numeral 2 with reference to Fig. 1) for the treatment of fluid, outlet port (Reference numeral 7 with reference to Fig. 1) the fluid tight installation key of liquid to be treated, manual force (forcing) pump is connected with flexible pipe at the ingress port (Reference numeral 6 with reference to Fig. 1) of liquid to be treated, force (forcing) pump is utilized to apply press in 10kPa and keep 10 seconds to blood processor, repeatedly carry out the operation interior pressure improved in units of 10kPa, until confirm that liquid infiltrates head (with reference to the Reference numeral 8 of Fig. 1, 9) with the interface of film fixed bed (with reference to the Reference numeral 5 of Fig. 1) till, using confirm infiltrate time in pressure as infiltrate withstand voltage.This evaluation is implemented respectively to five blood processors manufactured in the above described manner, 5 times on average withstand voltage be 508kPa, minimum withstand voltage be occur during 220kPa infiltrating.
(embodiment 2)
To internal diameter be 200 μm, thickness be 16000 hollow-fibre membranes of the polysulfones of 40 μm carry out harness form and hollow fiber membrane bundle, with two ends from body shell end respectively the mode of outstanding more than 7mm be inserted into the body shell of the polypropylene that total length is 285mm, body part internal diameter is 45.4mm, inner end diameter is 54.8mm, outer end diameter is 58.8mm, to the carbon dioxide laser that the end face at these two ends is 80W with the output of the patterned illumination of regulation, the hollow bulb of hollow-fibre membrane end face is sealed.Then, at the two ends of body shell (Reference numeral 3 with reference to Fig. 1), block (with reference to Fig. 6) is installed, with the position of body shell total length half for rotary middle spindle, as radius of turn, body shell is rotated the half of total length, utilize consequent centrifugal force, make the curable urethane resin injected from the ingress port (Reference numeral 1 with reference to Fig. 1) for the treatment of fluid and the outlet port (Reference numeral 2 with reference to Fig. 1) for the treatment of fluid, form film fixed bed at the two ends of body shell, hollow fiber membrane bundle and body shell are fixed.The diameter of film fixed bed in shell end is 54.8mm, and from shell end, 1mm extends laterally with diameter 54.8mm laterally, and from this position 0.1mm laterally, linearity undergauge is 51.6mm, the maximum extension 6.4mm laterally further from this position.But the overhang existed near the inner peripheral surface of body shell end towards outside is less than the film fixed bed part of 1.5mm.In the end from body shell, the position of 1.5mm laterally, cuts off such film fixed bed in the mode orthogonal with the axis of body shell, forms film fixed bed end face and makes hollow-fibre membrane opening.Afterwards, be 20kHz in frequency, under pressure is 0.4MPa, the deposition time is 0.7 second, the retention time is the condition of 1.0 seconds, ultrasonic wave coating carried out to head (Reference numeral 8,9 with reference to Fig. 1) body shell of polypropylene.In this embodiment 2, identical with embodiment 1, non-sectility face in the outer part, the face that the ratio inner peripheral surface of head being pressed on film fixed bed end face is cut off, the film namely formed by block inner surface are fixed aspect and carry out ultrasonic wave coating.
After the intermediate products of deposition are disintegrated, the inner peripheral surface diameter D0 of head (Reference numeral 9 with reference to Fig. 2 (a)) is 52.1mm, the point diameter D1 of the first connector portions (the Reference numeral 10b with reference to Fig. 2 (a)) is 55.0mm, deposition degree of depth L1 is 0.5mm, deposition width W 1 is 0.5mm, the internal diameter D2 of the second connector portions (the Reference numeral 10a with reference to Fig. 2 (a)) is 58mm, deposition degree of depth L2 is 1.2mm, deposition width W 2 is 0.4mm, the width of the first resin reservoir (Reference numeral 12 with reference to Fig. 2 (a)) is 0.4mm, be highly 0.7mm, the width of the second resin reservoir (Reference numeral 11 with reference to Fig. 2 (a)) is 1mm, be highly 0.7mm (with reference to Fig. 2 (b)).The width of the joint of the second connector portions is 0.4mm, and the sectional area of the second connector portions is 0.48mm
2, the horizontal range of the most inner circumferential of the first connector portions and the inner peripheral surface of head is 1.45mm, and the sectional area of the first connector portions is 0.125mm
2.Finally, install respectively and bale packing key with outlet port (Reference numeral 2 with reference to Fig. 1) at the ingress port (Reference numeral 6 with reference to Fig. 1) of liquid to be treated and the ingress port (Reference numeral 1 with reference to Fig. 1) of outlet port (Reference numeral 7 with reference to Fig. 1), treatment fluid, carry out gamma-rays sterilization, completing effective film area is 2.6m
2blood processor.
After having carried out the voltage-withstand test identical with embodiment 1,5 times average withstand voltage be 262kPa, minimum withstand voltage be during 130kPa occur infiltrate.
(comparative example 1)
Except there is no the first connector portions (the Reference numeral 10b with reference to Fig. 2 (a)), adopt the head identical with embodiment 1 shape, complete blood processor similarly to Example 1.The width of the joint of the second connector portions is 0.4mm, and the width of the joint of the second connector portions is multiplied by height and obtains sectional area is 0.48mm
2, the horizontal range of the most inner circumferential of the second connector portions and the inner peripheral surface of head is 2.95mm.After carrying out the voltage-withstand test identical with embodiment 1,5 times average withstand voltage be 30kPa, minimum withstand voltage be during 0kPa occur infiltrate.
(comparative example 2)
Except the point diameter D1 of the first connector portions (the Reference numeral 10b with reference to Fig. 2 (a)) is 45mm, deposition degree of depth L1 is 0.7mm, deposition width W 1 is 1.1mm, there is no the second connector portions (the Reference numeral 10a with reference to Fig. 2 (a)), and the width of the first resin reservoir (Reference numeral 12 with reference to Fig. 2 (a)) is 0.6mm, be highly 0.8mm, the width of the second resin reservoir (Reference numeral 11 with reference to Fig. 2 (a)) is 0.6mm, be highly beyond 0.8mm, adopt the head with embodiment 1 same shape, complete blood processor similarly to Example 1.The sectional area of the first connector portions is 0.493mm
2, the horizontal range of the most inner circumferential of the first connector portions and the inner peripheral surface of head is 1.75mm.After carrying out the voltage-withstand test identical with embodiment 1,5 times average withstand voltage be 69kPa, minimum withstand voltage be during 0kPa occur infiltrate.
(comparative example 3)
Except there is no the first resin reservoir (Reference numeral 12 with reference to Fig. 2 (a)) and the second resin reservoir (Reference numeral 11 with reference to Fig. 2 (a)), adopt the head with embodiment 1 same shape, complete blood processor similarly to Example 1.The width of the joint of the second connector portions is 0.4mm, and the sectional area of the second connector portions is 0.4mm
2, the horizontal range of the most inner circumferential of the first joint and the inner peripheral surface of head is 1.55mm, and the sectional area of the first connector portions is 0.075mm
2.After carrying out the voltage-withstand test identical with embodiment 1, occur when 5 voltage-withstand tests are all 0kPa infiltrating.After longitudinally being cut off by blood processor, the resin of fusing is full of between head and body shell end face, occurs the gap of 0.1 ~ 0.2mm between head inner peripheral surface and film fixed bed.
(comparative example 4)
Be used in when forming film fixed bed and the difform block of embodiment 1, its result, the diameter of body shell end is 44.2mm, and the maximum extension 7.5mm laterally from shell end, for the film fixed bed that the mode being more than 0.5mm with the overhang laterally from shell end near the inner peripheral surface of shell end is formed, head inner peripheral surface is pressed on and the orthogonal mode of the axis of body shell cuts off and the film fixed bed end face formed and body shell carry out ultrasonic wave coating in the position of 0.5mm laterally from shell end, complete blood processor similarly to Example 1 in addition.That is, from embodiment 1,2, comparative example 1 ~ 3 is different, in this comparative example 4, when carrying out ultrasonic wave coating, by head inner peripheral surface by the sectility face being pressed in film fixed bed.The width of the joint of the second connector portions is 0.4mm, and the sectional area of the second connector portions is 0.48mm
2, the horizontal range of the most inner circumferential of the first joint and the inner peripheral surface of head is 1.55mm, and the sectional area of the first connector portions is 0.125mm
2.After carrying out the voltage-withstand test identical with embodiment 1 to this blood processor, all occur when 0kPa infiltrating in 5 voltage-withstand tests.After longitudinally being cut off the position of infiltration, between head inner peripheral surface and film fixed bed, there is the gap of 0.1 ~ 0.3mm.
(comparative example 5)
Except the point diameter D1 of the first connector portions be 55.2mm, deposition degree of depth L1 be 0.3mm, deposition width W 1 for except 0.3mm, adopt the head identical with embodiment 2, complete blood processor according to the method identical with embodiment 1.The width of the joint of the second connector portions is 0.4mm, and the sectional area of the second connector portions is 0.48mm
2, the horizontal range of the most inner circumferential of the first joint and the inner peripheral surface of head is 1.55mm, and the sectional area of the first connector portions is 0.045mm
2.After carrying out the voltage-withstand test identical with embodiment 1,5 times average withstand voltage be 55kPa, minimum withstand voltage be during 0kPa occur infiltrate.After longitudinally being cut off the position of infiltration, the first connector portions is only crushed and is out of shape, in fact head and shell non-welded.
(comparative example 6)
Except the body shell of polypropylene is heated 30 minutes with temperature 50 C in baking oven, make that inner end diameter is contracted to 54.4mm, outer end diameter is contracted to beyond 58.4mm, adopt the method identical with embodiment 2 to complete blood processor.The width of the joint of the second connector portions is 0.2mm, and the sectional area of the second connector portions is 0.24mm
2, the horizontal range of the most inner circumferential of the first joint and the inner peripheral surface of head is 1.55mm, and the sectional area of the first connector portions is 0.125mm
2.But, there is bubble in the second connector portions local, and be not normally deposition.After carrying out the voltage-withstand test identical with embodiment 1,5 times average withstand voltage be 48kPa, minimum withstand voltage be during 10kPa occur infiltrate.
Description of reference numerals: 1 ... the ingress port for the treatment of fluid; 2 ... the outlet port for the treatment of fluid; 3 ... body shell; 4 ... hollow fiber membrane bundle; 4a ... hollow-fibre membrane; 5 ... film fixed bed; 6 ... the ingress port of liquid to be treated; 7 ... the outlet port of liquid to be treated; 8 ... head; 9 ... head; 10 ... ultrasonic wave coating portion; 10a ... the ultrasonic wave coating portion of shared joints; 10b ... the ultrasonic wave coating portion of banjo fixing butt jointing; 11 ... resin reservoir; 12 ... resin reservoir; 21 ... oscillator; 22 ... oscillator; 23 ... flared portion; 24 ... actuator; 25 ... plummer; 26 ... block; 31 ... main body container; 32 ... head; 33 ... ultrasonic wave coating portion; 34 ... ultrasonic wave coating portion; 35 ... film fixed bed; 36 ... gap; 37 ... endless elastomeric.
Claims (8)
1. a hollow fiber film assembly, possess: hollow fiber membrane bundle, receive described hollow fiber membrane bundle body shell, for described hollow fiber membrane bundle is fixed on the inwall of body shell end film fixed bed and be installed on shell opener end there is the introducing port of liquid to be treated or the head of export mouth, carry out ultrasonic wave coating in the region described head and described body shell being spread all at least two positions of complete cycle thus form liquid-tight structure, the feature of described hollow fiber film assembly is
Use shared joints to spread all over as to the side of body shell periphery and the medial surface of head the joint design that complete cycle carries out ultrasonic wave coating, use banjo fixing butt jointing to spread all over as to the end face of body shell and the medial surface of head the joint design that complete cycle carries out ultrasonic wave coating.
2. hollow fiber film assembly according to claim 1, is characterized in that,
It is 0.3 ~ 0.9mm that the weld width of described shared joints is multiplied by the sectional area highly obtained
2.
3. hollow fiber film assembly according to claim 1, is characterized in that,
It is 0.4 ~ 0.9mm that the weld width of described shared joints is multiplied by the sectional area highly obtained
2.
4. the hollow fiber film assembly according to any one of claims 1 to 3, is characterized in that,
The most inner circumferential of described banjo fixing butt jointing and the inner peripheral surface distance in the horizontal direction of head are 0.5 ~ 2.0mm.
5. the hollow fiber film assembly according to any one of Claims 1 to 4, is characterized in that,
The leg-of-mutton area that the half that the width of the guider of described banjo fixing butt jointing is multiplied by height obtains is 0.05 ~ 0.35mm
2.
6. the hollow fiber film assembly according to any one of Claims 1 to 5, is characterized in that,
In the inner circumferential side of banjo fixing butt jointing and outer circumferential side both sides, there is resin reservoir.
7. the manufacture method of a hollow fiber film assembly, it is the method manufacturing hollow fiber film assembly, described hollow fiber film assembly possesses: hollow fiber membrane bundle, receive the body shell of described hollow fiber membrane bundle, for described hollow fiber membrane bundle being fixed on the film fixed bed of the inwall of body shell end, and be installed on shell opener end there is the introducing port of liquid to be treated or the head of export mouth, carry out ultrasonic wave coating in the region described head and described body shell being spread all at least two positions of complete cycle simultaneously, the feature of the manufacture method of described hollow fiber film assembly is,
Spreading all over complete cycle to the side of body shell periphery and the medial surface of head utilizes shared joints to carry out ultrasonic wave coating, spreads all over complete cycle utilize banjo fixing butt jointing to carry out ultrasonic wave coating to the end face of body shell and the medial surface of head.
8. a hollow fiber film assembly, the many hollow-fibre membranes be made up of hollow-fibre membrane polymer are carried out to harness and are inserted into body shell, after film fixed bed note type block is installed on described body shell end, inject film fixed bed polymer to body shell end and form film fixed bed, thus hollow fiber membrane bundle is fixed on body shell, after described film fixed bed solidification, in the mode of the both ends of the surface making hollow fiber membrane bundle opening toward the outer side by a film fixed bed excision part, ultrasonic wave coating is carried out simultaneously to manufacture hollow fiber film assembly in the region that spread all at least two positions of complete cycle to the body shell after a part of film fixed bed of excision and head, the feature of described hollow fiber film assembly is,
Inner portion face and the end contact of film fixed bed do not excised.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2012073761 | 2012-03-28 | ||
JP2012-073761 | 2012-03-28 | ||
PCT/JP2013/058545 WO2013146663A1 (en) | 2012-03-28 | 2013-03-25 | Hollow fiber membrane module |
Publications (2)
Publication Number | Publication Date |
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CN104245097A true CN104245097A (en) | 2014-12-24 |
CN104245097B CN104245097B (en) | 2016-06-08 |
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Family Applications (1)
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CN201380015302.XA Active CN104245097B (en) | 2012-03-28 | 2013-03-25 | Hollow fiber film assembly |
Country Status (8)
Country | Link |
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EP (1) | EP2832423A4 (en) |
JP (1) | JP6028730B2 (en) |
KR (1) | KR20140137417A (en) |
CN (1) | CN104245097B (en) |
CA (1) | CA2868711A1 (en) |
HK (1) | HK1203878A1 (en) |
TW (1) | TWI554292B (en) |
WO (1) | WO2013146663A1 (en) |
Cited By (1)
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CN112108011A (en) * | 2020-09-29 | 2020-12-22 | 杭州富阳万博空分设备有限公司 | Precision filter sealing shell and using method thereof |
Families Citing this family (7)
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EP3278821A4 (en) * | 2015-04-03 | 2018-04-04 | Asahi Kasei Medical Co., Ltd. | Hollow fiber membrane blood purifying device |
CN105563807A (en) * | 2016-02-25 | 2016-05-11 | 石家庄喜得宝医疗器械有限公司 | Fixing structure for filtering film in medical instrument |
TWI630952B (en) * | 2016-03-31 | 2018-08-01 | 旭化成醫療股份有限公司 | Hollow fiber membrane module and manufacturing method of hollow fiber membrane module |
US20190105608A1 (en) * | 2016-03-31 | 2019-04-11 | Asahi Kasei Medical Co., Ltd. | Hollow fiber membrane module and manufacturing method therefor |
EP3290100B1 (en) * | 2016-08-31 | 2020-08-19 | Gambro Lundia AB | Diffusion and/or filtration device |
JP6242456B2 (en) * | 2016-10-06 | 2017-12-06 | 株式会社キッツマイクロフィルター | Hollow fiber membrane module |
DE102020125108A1 (en) | 2020-09-25 | 2022-03-31 | Enmodes Gmbh | Device for mass transfer and method for its manufacture |
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- 2013-03-25 KR KR1020147028070A patent/KR20140137417A/en not_active Application Discontinuation
- 2013-03-25 WO PCT/JP2013/058545 patent/WO2013146663A1/en active Application Filing
- 2013-03-25 CA CA2868711A patent/CA2868711A1/en not_active Abandoned
- 2013-03-25 JP JP2013525065A patent/JP6028730B2/en active Active
- 2013-03-25 CN CN201380015302.XA patent/CN104245097B/en active Active
- 2013-03-27 TW TW102110913A patent/TWI554292B/en active
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2015
- 2015-05-07 HK HK15104340.2A patent/HK1203878A1/en unknown
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JPWO2013146663A1 (en) | 2015-12-14 |
TWI554292B (en) | 2016-10-21 |
EP2832423A4 (en) | 2016-04-06 |
KR20140137417A (en) | 2014-12-02 |
WO2013146663A1 (en) | 2013-10-03 |
JP6028730B2 (en) | 2016-11-16 |
EP2832423A1 (en) | 2015-02-04 |
TW201343211A (en) | 2013-11-01 |
CA2868711A1 (en) | 2013-10-03 |
CN104245097B (en) | 2016-06-08 |
HK1203878A1 (en) | 2015-11-06 |
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