CN104147688A - Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof - Google Patents
Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof Download PDFInfo
- Publication number
- CN104147688A CN104147688A CN201410374435.2A CN201410374435A CN104147688A CN 104147688 A CN104147688 A CN 104147688A CN 201410374435 A CN201410374435 A CN 201410374435A CN 104147688 A CN104147688 A CN 104147688A
- Authority
- CN
- China
- Prior art keywords
- plastotype
- adventitia
- deionized water
- firming body
- source applicator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a rapidly-formed self-adaptive afterloading brachytherapy source applicator and a manufacturing method thereof. The rapidly-formed self-adaptive afterloading brachytherapy source applicator comprises a solidified body and a source application tube, wherein the solidified body is formed by mixing and solidifying powdered alginate materials and deionized water, and the source application tube is embedded in the solidified body. The solidified body is in a structure fitting a tumor shape, and the structure is formed after a shaping outer membrane of the mixture of the powdered alginate materials and deionized water is embedded to an oncotherapy portion of a patient. The source application tube is embedded in the solidified body after the shaping outer membrane is removed after the mixture in the shaping outer membrane is solidified. By the rapidly-formed self-adaptive afterloading brachytherapy source applicator and the manufacturing method thereof, the patient can get a suitable individual source applicator during tumor afterloading brachytherapy, a three-dimensional dose distribution can be obtained by the aid of the source applicator, and accordingly favorable tumor control rate and less complications can be achieved. The rapidly-formed self-adaptive afterloading brachytherapy source applicator has the advantages of self adaptability to therapy portions, quickness in forming, simplicity in operation, low manufacturing cost and the like.
Description
Technical field
The invention belongs to tumour radiotherapy apparatus field, be specifically related to closely rear source applicator and preparation method thereof of a kind of rapid shaping self adaptation.
Background technology
At present, along with the development of tumour radiotherapy technology, closely fill afterwards radiotherapy and start to be widely used among the treatment of malignant tumor.For some, cannot carry out the patients with terminal of operative treatment especially, radiotherapy is its most effectively treatment means, and closely fill afterwards radiotherapy, is bringing into play very important effect in whole therapeutic process.But present stage, the tumor apparatus for wave-energy source that closely after-loading therapy is used mostly is standardization apparatus for wave-energy source.Standardization apparatus for wave-energy source shape, volume are fixed.Standardization apparatus for wave-energy source adopts rare metal or high strength organic material to make more, expensive.Standardization apparatus for wave-energy source formed dose distribution in therapeutic process is fixed.For tumor patient, due to each patient's tumor shape, volume and to invade the position of profit different, when treating, standardization of application apparatus for wave-energy source cannot reach the accurate close-range treatment of three-dimensional of individuation, may cause the therapeutic dose deficiency or the normal structure excess that give, thus cause tumor control failure or side reaction serious.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, closely rear source applicator and preparation method thereof of a kind of rapid shaping self adaptation is provided.
For achieving the above object, the technical solution used in the present invention is as follows:
Rapid shaping self adaptation is a rear source applicator closely, and include and adopt the alginate material of powdery and the firming body of the mixing cured rear formation of deionized water, and at the inner stock pipe of implanting of firming body; Described firming body is will the structure of the applicable tumor shape forming behind the plastotype adventitia patients with implantation oncotherapy position of powder alginate material and deionized water compound be housed; Described stock pipe is to implant firming body inside after plastotype adventitia is removed in taking-up after the compound in plastotype adventitia solidifies.
Above-mentioned alginate material mixes with the ratio that deionized water adds water 20～25ml according to 10 grams of powder.
The present invention also provides a kind of closely method of rear source applicator of rapid shaping self adaptation of making, and the method is carried out in accordance with the following steps:
Step 1, chooses the alginate material of powdery, and alginate material is mixed by a certain percentage with deionized water, after mixing, adjusts and mixes evenly;
Step 2, mixes uniform material by tune and packs in plastotype adventitia, then will the plastotype adventitia patients with implantation oncotherapy position of step 1 gained compound be housed, and compacting, and itself and tumor area are fitted tightly;
Step 3, keeps the outer film location of plastotype motionless, after the material cured in plastotype adventitia, the plastotype adventitia that firming body is housed is taken out, and removes plastotype adventitia, with clear water, removes the disintegrating slag on firming body;
Step 4, at the inner stock pipe of implanting of firming body, obtains the only rear source applicator of distance of rapid shaping according to clinical requirement.
Further, in step 1, alginate material mixes with the ratio that deionized water adds water 20～25ml in 10 grams of powder.
Further, in step 2, described plastotype adventitia is the rubber film bag that thickness is less than 0.5mm, and its membranous wall is thin, and good toughness, with alginate material adhesion.
Further, in step 1, alginate material and deionized water are put into leather cup and adopt to adjust and mix cutter and adjusts and mix, mixing time, in 30 seconds, is adjusted while mixing with adjusting and is mixed cutter and mix by " 8 " font tune that pressurizes along leather cup wall, and material mixing is evenly distributed.
Rapid shaping self adaptation provided by the invention is rear source applicator closely, in tumor closely in after-loading therapy process, patient can obtain an individuation apparatus for wave-energy source that is applicable to oneself, by this apparatus for wave-energy source, obtain the dose distribution of a suitable type, thereby obtain satisfied tumor control rate and less complication occurs simultaneously, and this apparatus for wave-energy source has self adaptation therapentic part, shaping speed is fast, simple to operate, the advantages such as cost of manufacture is low, source applicator after adopting manufacture method of the present invention to make closely, rapidly and efficiently, cost is low, individual adaptability is good, therapeutic effect is good.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.
The rapid shaping self adaptation of the embodiment of the present invention is rear source applicator closely, and include and adopt the alginate material of powdery and the firming body of the mixing cured rear formation of deionized water, and at the inner supply radiator duct of implanting of firming body; Firming body is will the structure of the applicable tumor shape forming behind the plastotype adventitia patients with implantation oncotherapy position of powder alginate material and deionized water compound be housed; Supply radiator duct is to implant firming body inside after plastotype adventitia is removed in taking-up after the compound in plastotype adventitia solidifies.Alginate material mixes with the ratio that deionized water adds water 20～25ml according to 10 grams of powder.
This rapid shaping self adaptation is rear source applicator closely, select alginate material as the material of rapid shaping, before treatment, be made into the firming body of an applicable tumor shape, then in firming body, implant the supply radiator duct road of clinical needs, form body apparatus for wave-energy source one by one.This rapid shaping self adaptation closely rear source applicator is specifically made as follows:
Step 1, choose the alginate material of powdery, the ratio that alginate material is added to water 20～25ml with deionized water in 10 grams of powder is mixed and is put into leather cup and adopt to adjust and to mix cutter and adjust and mix, mixing time is in 30 seconds, when tune is mixed, with tune, mix cutter and adjust and mix by the pressurization of " 8 " font along leather cup wall, material mixing is evenly distributed; Step 2, mixes even compound by tune and packs in the thin-walled plastotype adventitia of being made by quality of rubber materials, then will the plastotype adventitia patients with implantation oncotherapy position of gained compound be housed, and compacting, and itself and tumor area are fitted tightly; Step 3, keeps the outer film location of plastotype motionless, after the material cured in plastotype adventitia, the plastotype adventitia that firming body is housed is taken out, and removes plastotype adventitia, with clear water, removes the disintegrating slag on firming body; Step 4, at the inner supply radiator duct of implanting of firming body, obtains closely rear source applicator of rapid shaping according to clinical requirement.Apparatus for wave-energy source of the present invention, when making, by being equipped with before the plastotype adventitia patients with implantation oncotherapy position of compound, need to fix position to patient, and therapentic part is exposed to sterilization.
Adopt manufacture method of the present invention to make closely rear source applicator of this rapid shaping self adaptation, always make working time 4-10 minute, wherein adjust and mix and only need 2-3 minute hardening time.And closely, suitable type is good, is easy to individualized treatment for made apparatus for wave-energy source and the laminating of oncotherapy district.
The rapid shaping self adaptation that the embodiment of the present invention obtains is rear source applicator closely, draws by experiment, and the deformation recovery value of apparatus for wave-energy source is 95%; Compressive strain value is between 5%～20%; Comprcssive strength is 0.35MPa.
Experimental Comparison: for stump recurrence patient after operation for cervical carcinoma, tumor is invaded profit along postoperative stump to intraperitoneal.Carrying out tumor closely during afterloading irradiation, standardization of application apparatus for wave-energy source can only be treated 1/3 pre-defence area and tumor stump surface on vagina, cannot to Intraabdominal tumor area, carry out plesioradiotherapy to invading profit.
The rapid shaping of the application of the invention is rear source applicator closely, produces the apparatus for wave-energy source that is applicable to this patient, and apparatus for wave-energy source comprises a plurality of supply radiator ducts, can carry out tissue space implantation.Whole apparatus for wave-energy source irradiates when can accomplish to take into account on vagina 1/3 pre-defence area and recurrent tumor district.The manufacturing process of whole apparatus for wave-energy source is 3 minutes, use this rapid shaping closely after source applicator can make whole tumor area can reach 98% prescribed dose.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (6)
- Rapid shaping self adaptation closely after a source applicator, it is characterized in that: include and adopt the alginate material of powdery and the firming body of the mixing cured rear formation of deionized water, and at the supply radiator duct of the inner implantation of firming body; Described firming body is will the structure of the applicable tumor shape forming behind the plastotype adventitia patients with implantation oncotherapy position of powder alginate material and deionized water compound be housed; Described supply radiator duct is to implant firming body inside after plastotype adventitia is removed in taking-up after the compound in plastotype adventitia solidifies.
- Rapid shaping self adaptation according to claim 1 closely after source applicator, it is characterized in that: described alginate material mixes with the ratio that deionized water adds water 20～25ml according to 10 grams of powder.
- 3. make a closely method for rear source applicator of rapid shaping self adaptation, it is characterized in that: described method is carried out in accordance with the following steps:Step 1, chooses the alginate material of powdery, and alginate material is mixed by a certain percentage with deionized water, after mixing, adjusts and mixes evenly;Step 2, mixes uniform compound by tune and packs in plastotype adventitia, then will the plastotype adventitia patients with implantation oncotherapy position of step 1 gained compound be housed, and compacting, and itself and tumor area are fitted tightly;Step 3, keeps the outer film location of plastotype motionless, after the material cured in plastotype adventitia, the plastotype adventitia that firming body is housed is taken out, and removes plastotype adventitia, with clear water, rinses, and removes the disintegrating slag on firming body;Step 4, at the inner stock pipe of implanting of firming body, obtains closely rear source applicator of rapid shaping according to clinical requirement.
- 4. manufacture method according to claim 2, is characterized in that: in step 1, alginate material mixes with the ratio that deionized water adds water 20～25ml in 10 grams of powder.
- 5. manufacture method according to claim 2, is characterized in that: in step 2, described plastotype adventitia is the rubber film bag that thickness is less than 0.5mm, and its membranous wall is thin, and good toughness, with alginate material adhesion.
- 6. manufacture method according to claim 2, it is characterized in that: in step 1, alginate material and deionized water are put into leather cup to be adopted to adjust and mixes cutter and adjust and mix, mixing time is in 30 seconds, when tune is mixed, with tune, mix cutter and adjust and mix by the pressurization of " 8 " font along leather cup wall, material mixing is evenly distributed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410374435.2A CN104147688A (en) | 2014-07-31 | 2014-07-31 | Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410374435.2A CN104147688A (en) | 2014-07-31 | 2014-07-31 | Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104147688A true CN104147688A (en) | 2014-11-19 |
Family
ID=51873443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410374435.2A Pending CN104147688A (en) | 2014-07-31 | 2014-07-31 | Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104147688A (en) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084002A (en) * | 1988-08-04 | 1992-01-28 | Omnitron International, Inc. | Ultra-thin high dose iridium source for remote afterloader |
| CN1130133A (en) * | 1994-11-22 | 1996-09-04 | 照明及图象公司 | Scultapture article and its making method |
| CN1177609A (en) * | 1997-06-20 | 1998-04-01 | 张冬青 | Formula for making structural section of children's hand and foot mould, and production process thereof |
| WO1999055386A2 (en) * | 1998-04-10 | 1999-11-04 | Battelle Memorial Institute | Stimulus sensitive gel with radioisotope and methods of making |
| CN2426743Y (en) * | 2000-05-16 | 2001-04-18 | 佛山市第一人民医院 | Device for applying media in cavum nasopharyngeum |
| CN2427231Y (en) * | 2000-05-29 | 2001-04-25 | 陈宝明 | Apparatus for post-erection of wave-energy source (or the like) for vagina |
| WO2007134126A2 (en) * | 2006-05-09 | 2007-11-22 | Worldwide Medical Technologies Llc | After-loader devices and kits and methods for their use |
| CN101516432A (en) * | 2006-07-28 | 2009-08-26 | 得克萨斯大学体系董事会 | Adaptive intracavitary brachytherapy applicator |
| CN102798540A (en) * | 2012-07-20 | 2012-11-28 | 同济大学 | Method for quickly and stably picking fragile tissue of animal for experiments |
| CN103736200A (en) * | 2013-12-31 | 2014-04-23 | 原子高科股份有限公司 | Preparation method of radioactive particle chain |
| CN103957984A (en) * | 2011-09-30 | 2014-07-30 | 纪念斯隆-凯特林癌症中心 | Internal body cavity therapeutic applicator arrangements and methods for using the same |
-
2014
- 2014-07-31 CN CN201410374435.2A patent/CN104147688A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084002A (en) * | 1988-08-04 | 1992-01-28 | Omnitron International, Inc. | Ultra-thin high dose iridium source for remote afterloader |
| CN1130133A (en) * | 1994-11-22 | 1996-09-04 | 照明及图象公司 | Scultapture article and its making method |
| CN1177609A (en) * | 1997-06-20 | 1998-04-01 | 张冬青 | Formula for making structural section of children's hand and foot mould, and production process thereof |
| WO1999055386A2 (en) * | 1998-04-10 | 1999-11-04 | Battelle Memorial Institute | Stimulus sensitive gel with radioisotope and methods of making |
| CN2426743Y (en) * | 2000-05-16 | 2001-04-18 | 佛山市第一人民医院 | Device for applying media in cavum nasopharyngeum |
| CN2427231Y (en) * | 2000-05-29 | 2001-04-25 | 陈宝明 | Apparatus for post-erection of wave-energy source (or the like) for vagina |
| WO2007134126A2 (en) * | 2006-05-09 | 2007-11-22 | Worldwide Medical Technologies Llc | After-loader devices and kits and methods for their use |
| CN101516432A (en) * | 2006-07-28 | 2009-08-26 | 得克萨斯大学体系董事会 | Adaptive intracavitary brachytherapy applicator |
| CN103957984A (en) * | 2011-09-30 | 2014-07-30 | 纪念斯隆-凯特林癌症中心 | Internal body cavity therapeutic applicator arrangements and methods for using the same |
| CN102798540A (en) * | 2012-07-20 | 2012-11-28 | 同济大学 | Method for quickly and stably picking fragile tissue of animal for experiments |
| CN103736200A (en) * | 2013-12-31 | 2014-04-23 | 原子高科股份有限公司 | Preparation method of radioactive particle chain |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2007323660B2 (en) | Device and method for immobilizing patients for breast radiation therapy | |
| Logar et al. | Development and assessment of 3D-printed individual applicators in gynecological MRI-guided brachytherapy | |
| EP2701804A1 (en) | Apparatus for loading dosimetrically customizable brachytherapy carriers | |
| Chiu et al. | Three-dimensional printer-aided casting of soft, custom silicone boluses (SCSBs) for head and neck radiation therapy | |
| Zhao et al. | The design of an individualized cylindrical vaginal applicator with oblique guide holes using 3D modeling and printing technologies | |
| Kowalik et al. | Individual applicator for brachytherapy for various sites of superficial malignant lesions | |
| Wang et al. | Image guided radiation therapy boost in combination with high-dose-rate intracavitary brachytherapy for the treatment of cervical cancer | |
| Liu et al. | Computed Tomography–Guided Interstitial Brachytherapy for Locally Advanced Cervical Cancer: Introduction of the Technique and a Comparison of Dosimetry With Conventional Intracavitary Brachytherapy | |
| Pugh et al. | Radiation therapy modalities in prostate cancer | |
| Saitoh et al. | High-dose-rate interstitial brachytherapy with computed tomography-based treatment planning for patients with locally advanced uterine cervical carcinoma | |
| Ward et al. | Future directions from past experience: a century of prostate radiotherapy | |
| CN107998447B (en) | Conformal radiotherapy tissue equivalent compensation glue and preparation method and application thereof | |
| Tang et al. | Dosimetric comparison of graphical optimization and inverse planning simulated annealing for brachytherapy of cervical cancer | |
| CN204319524U (en) | A kind of locating pad for tumor radiotherapy | |
| CN104147688A (en) | Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof | |
| Villalba et al. | A new template for MRI-based intracavitary/interstitial gynecologic brachytherapy: design and clinical implementation | |
| Nilsson et al. | A unique approach to high-dose-rate vaginal mold brachytherapy of gynecologic malignancies | |
| Nakamura et al. | Successful treatment of neoadjuvant therapy for papillary tumor of the pineal region | |
| WO2011041500A3 (en) | System and methods photon-based radiotherapy and radiosurgery delivery | |
| Kim et al. | Dosimetric evaluation of magnetic resonance imaging-based intracavitary brachytherapy for cervical cancer | |
| Biltekin et al. | Dosimetric comparison of two different applicators and rectal retraction methods used in inverse optimization-based intracavitary brachytherapy for cervical cancer | |
| Koh et al. | Comparing a volume based template approach and ultrasound guided freehand approach in multicatheter interstitial accelerated partial breast irradiation | |
| Jreij et al. | Applicators used for vaginal high dose rate brachytherapy: Effect of type and shape on dose distribution and toxicity, a literature review | |
| Murofushi et al. | A clinical evaluation of American Brachytherapy Society consensus guideline for bulky vaginal mass in gynecological cancer | |
| Yuan et al. | Subdermal injection of hyaluronic acid to decrease skin toxicity from radiation delivered with low-dose-rate brachytherapy for cancer patients |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141119 |