CN104089804A - Biological sample processing system - Google Patents
Biological sample processing system Download PDFInfo
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- CN104089804A CN104089804A CN201410311189.6A CN201410311189A CN104089804A CN 104089804 A CN104089804 A CN 104089804A CN 201410311189 A CN201410311189 A CN 201410311189A CN 104089804 A CN104089804 A CN 104089804A
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Abstract
The invention discloses a biological sample processing system which comprises a system base plate, a glass slide placing platform, a sample cell, a biological sample dropping device, a sample processing cavity body, a control system and a human-computer interface, wherein the biological sample dropping device comprises a space motion mechanism, a pipetting device and a glass slide taking and putting device, and the space motion mechanism is controlled by the control system, so that a preset moving track is output by a moving part of the space motion mechanism, a glass slide is automatically arranged at the beginning of an experiment, a biological sample is automatically sucked and transferred onto the surface of the glass slide by the pipetting device, the glass slide is automatically removed after the completion of the experiment, and the temperature of the biological sample cell can be adjusted. According to the biological sample processing system disclosed by the invention, the automatic dropping operation of chromosomes can be performed in a high-throughput mode; the biological sample processing system has the advantages of small size, low production cost, convenience in installation and maintenance and low energy consumption and is especially suitable for analyzing cytogenetics; the dropping process automation of the chromosomes is realized, the analysis efficiency is improved, and the biological sample processing quality is guaranteed.
Description
Technical field
The present invention relates to a kind of biological sample experimental provision, be applicable to automatic drip sheet operative technique field and cytogenetics experimental technique field in Bio-specimen Preparation process.
Background technology
According to classical cytogenetics, the chromosome of preparing from cell, can analyze under the microscope, and the defect that may exist is diagnosed.Chromosome preparation need to be carried out hypotonic, fixing, dry, aging, enzymic digestion and show the processing such as band the cell of results, after these processing, just can under the microscope the chromosome of cell be analyzed, to judge whether to exist chromosome abnormality.This classical method is in use to now at the beginning of setting up always.
In the past few decades, Cytogenetic techniques has obtained many-sided important breakthrough, as cell synchronization culture technique, and chromosome high resolution technology and original position amniocyte chromosome analysis technology etc.Although obtained these great breakthroughs aspect Cytogenetic techniques, but reach best Chromosome spread degree and consistance and repeated very difficult problem, very difficult consistance and the repeatability that ensures each its Chromosome spread of sample of analyzing as cytogenetics of being still of height thereof.
According to Chromosome spread principle of dynamics, in conventional chromosome preparation process, there is very large impact in the quality that the temperature and humidity of environment is prepared chromosome.For solving the impact of environmental factor on Chromosome spread degree, product Optichrome Bioexperiment instrument by name that the Bioexperiment instrument of the product Chromprep S by name that Le Chen bio tech ltd, Shanghai manufactures, Italian Euroclone company manufacture, Thermotron Cytogenetic chamber company of the U.S. and Japanese Hanabin Metaphase spreader company have developed respectively manual Chromosome spread instrument, well solve the impact of environmental factor on Chromosome spread, guaranteed chromosomal preparation quality.
Along with increasing of analytical specimen amount, manually Chromosome spread instrument more and more cannot meet the demand of routine analysis work.Hanabin company of Japan has developed automatic staining body and has dripped sheet instrument Metaphase Auto-spreader, substantially solved high flux problem prepared by chromosome, but this system is a site type machine, volume is larger, complex structure, energy consumption is higher, produces, operation and maintenance cost is very high.
Summary of the invention
In order to solve prior art problem, the object of the invention is to overcome the deficiency that prior art exists, a kind of biological sample disposal system is provided, can carry out the operation of chromosome automatic drip sheet high flux, volume is little, and production cost is low, installation and maintenance is convenient, and energy consumption is low.The present invention is specially adapted to CYTOGENETIC ANALYSIS OF ONE, realizes chromosome and drip the robotization of sheet process, improves analysis efficiency, has ensured the quality of biological sample processing.
Create object for reaching foregoing invention, the present invention adopts following technical proposals:
A kind of biological sample disposal system, comprise system backplane, microslide placement platform, sample cell, biological sample drips sheet devices and sample preparation chamber, microslide placement platform is fixedly installed in system backplane, on microslide placement platform, microslide is set, also comprise control system and man-machine interface, control system is dripped sheet devices by controlling biological sample, pending biological sample is transferred in slide surface, user realizes information interaction by man-machine interface and control system, biological sample drips sheet devices and comprises spatial movement mechanism, liquid-transfering device and microslide fetching device, the fixed part of spatial movement mechanism is fixedly connected with system backplane by support, the bottom of support is fixedly installed in system backplane, the action part of spatial movement mechanism is fixedly connected with microslide fetching device with liquid-transfering device respectively, control system is by controlling spatial movement mechanism, the movement locus that the motion parts output of spatial movement mechanism is set, in the time that biological sample experiment starts, make microslide fetching device automatically place microslide on microslide placement platform, and liquid-transfering device is also transferred to biological sample automatic sucking from the sample hose of sample cell on the surface of microslide automatically, after biological sample is finished dealing with, from microslide placement platform, automatic moving is except microslide, microslide placement platform is arranged in sample preparation cavity, sample preparation cavity is enclosed and is formed the chamber with open topped by shell cavity, microslide placement platform is arranged on position under the open topped of counter sample process chambers, also be equipped with specially set temperature control device, humidity conditioner and air flow controller for sample preparation cavity, realize respectively the automatic control to the temperature in the internal chamber of sample preparation cavity, humidity and gas velocity by control system, sample cell is provided with temperature control equipment, and sample cell is used for placing biological sample, and temperature control equipment regulates and controls the temperature in sample cell.
As the improvement of technical solution of the present invention, system also comprises label machine and barcode scanner, label machine is connected with control system signal respectively with barcode scanner, application barcode scanner is swept and is read the label of pending biological sample, and send scanning information to control system, control system, according to the establishing method of biological sample processing and flow process, sends label printing instruction to label machine, prints the label that contains sample and microslide information.
As the improvement of technique scheme, system also comprises exhaust gas adsorption device, pass through support, exhaust gas adsorption device is arranged on to sample preparation cavity, microslide placement platform, sample cell and biological sample and drips the top of sheet devices, the harmful gas producing for automatic absorbing biological sample processing procedure.
Above-mentioned exhaust gas adsorption device is preferably made up of filtrator and air exhauster, realize the gas producing in automatic absorbing Bioexperiment process, in filtrator, be provided with absorbent filtering layer, the adsorbent preferably adopting is the potpourri of any one or any several compositions in soda lime, calcium lime and acticarbon.
The spatial movement mechanism that above-mentioned biological sample drips sheet devices preferably adopts XYZ three-shaft linkage device, by X-axis mechanism, the mutually orthogonal controlled motion mechanism composition in space between three mechanism's axis of Y-axis mechanism and Z-axis mechanism, X-axis mechanism, Y-axis mechanism and Z-axis mechanism have respectively fixed part and moving part, wherein the fixed part of X-axis mechanism is fixedly installed on the column of support, the fixed part of Y-axis mechanism is fixedly installed on the moving part of X-axis mechanism, the fixed part of Z-axis mechanism is fixedly installed on the moving part of Y-axis mechanism, liquid-transfering device and microslide fetching device are fixedly installed on the moving part of Z-axis mechanism, the moving part of the each controlled motion mechanism of XYZ three-shaft linkage device carries out corresponding space line displacement movement by motor independently respectively, under the transmission of the independent exclusive motor in X-axis mechanism, the fixed part of the moving part QianYZhou mechanism of X-axis mechanism carries out side-to-side movement, under the transmission of the independent exclusive motor in Y-axis mechanism, the fixed part of the moving part traction Z-axis mechanism of Y-axis mechanism seesaws, under the transmission of the independent exclusive motor at Z-axis mechanism, the moving part of Z-axis mechanism moves up and down, by each motor of control system control XYZ three-shaft linkage device, controlling respectively liquid-transfering device and microslide fetching device moves according to the space path of setting, thereby realize the automatic transporting of microslide, place and remove process, and realize the transfer of biological sample, draw and drip and let slip journey.Each motor is stepper motor, direct current generator, DC speed-reducing, step-servo motor and DC servo motor.Preferably step-servo motor and DC servo motor, can accurately monitor motor operation course.Sensor is that photoelectric sensor, Hall element, capacitive transducer or infrared sensor are waited until, can detect motor movement position.Preferred light electric transducer, use and easy for installation.The side-to-side movement of X-axis winding machine, Y-axis winding machine seesaws, and Z-axis mechanism is realized and being moved up and down.
As the improvement of technique scheme of the present invention, preferably form sample preparation platform by temperature control equipment and the microslide placement platform of above-mentioned sample preparation cavity, wherein temperature control equipment is preferably made up of temperature control element, radiating block, temperature-dropping fan and temperature sensor, temperature sensor detects the temperature of microslide placement platform in real time, the temperature signal that control system gathers according to temperature sensor, the detected value of temperature and setting value are compared, temperature control element is regulated and controled, realize the control of the temperature to microslide placement platform.Above-mentioned temperature control element preferably adopts PTC heating element or semiconductor temperature-control element, and preferably adopts semiconductor temperature-control element, by heating or the cooling of temperature control element, microslide placement platform is heated up or lowers the temperature control.
The humidity conditioner of above-mentioned sample preparation cavity and air flow controller are preferably by being integrated into constant humidity air-stream generating device in the outside of sample preparation cavity, , constant humidity air-stream generating device is the cavity of a sealing, sample preparation cavity has air intake opening, the air intake opening of constant humidity air-stream generating device is communicated with by air delivering pipeline with the gas outlet of constant humidity air-stream generating device, air-stream generating device is set in constant humidity air-stream generating device and realizes the flow control of delivery air as the air flow controller of sample preparation cavity, air-stream generating device preferably adopts blower fan or air pump, constant humidity air-stream generating device is mainly by humidification water pond, water heating elements, water temperature sensor, condenser, dehumidifying semiconductor, heat-conducting block, cooling fan and Temperature Humidity Sensor composition, control system control water heating elements heats and manufactures water vapor the water body storing in humidification water pond, water temperature sensor detects the water temperature in humidification water pond in real time, control system is according to the comparative result of the temperature detection value of water and setting value, water heating elements is regulated and controled, realize the accuracy controlling to water temperature, extraneous air is under the driving of air-stream generating device, enter the inside cavity of constant humidity air-stream generating device, the flow through surface of the water body storing in humidification water pond, carry water vapor and after humidification, entered the pipeline of condenser, flow through the successively again measurement point of dehumidifying semi-conductive exsiccation region and Temperature Humidity Sensor, finally flow out from gas outlet, enter sample preparation inside cavity, cooling fan carries out cooling by heat-conducting block to dehumidifying semiconductor, the heat that the semiconductor that makes to dehumidify produces is discharged in environment through heat-conducting block and cooling fan successively, the temperature-humidity signal that control system gathers according to Temperature Humidity Sensor, the detected value of humiture and setting value are compared, to dehumidifying, semi-conductive duty regulates and controls, realize the humidity control of the air-flow to the dehumidifying semi-conductive exsiccation region of flowing through.
Above-mentioned water heating elements preferably adopts PTC heating element or semiconductor temperature-control element, by the heating of water heating elements, controls the humidity of the air-flow of the humidification water panel surface of flowing through.
As the improvement of technique scheme of the present invention, on said system base plate, preferably fixed installation microslide is piled frame and microslide layer frame, in the time that biological sample experiment starts, controlling slide fetching device picks up microslide automatically from microslide heap frame, after carrying, pass through again the open topped of sample preparation cavity, enter the inside of sample preparation cavity, microslide is placed into above slide platforms, and after biological sample has been tested, controlling slide fetching device picks up microslide automatically from slide platforms, after carrying, pass through again the open topped of sample preparation cavity, leave sample preparation cavity, microslide is placed into respectively in the equivalent layer frame of microslide layer frame.
As the improvement of technique scheme of the present invention, controllable temperature sample cell is arranged in system backplane, the temperature control equipment of controllable temperature sample cell comprises temperature sensor, temperature controller, radiator and cooling blower, the sample cell casing top of controllable temperature sample cell is provided with the sunk type sample well of multiple openings, in sunk type sample well, place biological sample, temperature sensor detects the internal temperature of sample cell casing in real time, the temperature signal that control system gathers according to temperature sensor, the detected value of temperature and setting value are compared, temperature controller is regulated and controled, realize the internal temperature control to sample cell casing.
Above-mentioned temperature controller preferably adopts PTC heating element or semiconductor temperature-control element, and preferred semiconductor temperature control element, by heating or the cooling of temperature controller, heats up or lowers the temperature control the sample in sample cell casing.
As the improvement of technique scheme of the present invention, in system backplane, be provided with rifle head box and de-rifle head device, biological sample drips the action part energy automatic loading and unloading sample loading gun head of the spatial movement mechanism of sheet devices, control system is by controlling spatial movement mechanism, realize automatic sampling gun automatically take arms head, automatic trip rifle head, mixed liquid and add imbibition operation, sample loading gun comprises motor, piston and rifle head, and electric machine main shaft is by driving piston up-down to carry out imbibition and liquid feeding operation.
The motor of above-mentioned sample loading gun preferably adopts stepper motor, direct current generator or reducing motor.
Above-mentioned microslide fetching device preferably includes negative pressure pump, pressure transducer and microslide suction nozzle, the pressure signal that control system gathers according to pressure transducer, the detected value of pressure and setting value are compared, negative pressure pump is regulated and controled, realize the work method control to microslide suction nozzle, and drip the spatial movement mechanism that sheet devices comprises, the automatic operation of getting sheet and film releasing of existing microslide by interlock biological sample.
Above-mentioned control system preferably adopts any one in moving control card, single-chip microcomputer, computing machine, programmable controller.
The present invention compared with prior art, has following apparent outstanding substantive distinguishing features and remarkable advantage:
1. the constant humidity air-stream generating device of biological sample disposal system of the present invention, temperature, humidity and gas velocity in Quality control process chambers accurately, the samples such as peripheral blood, amniotic fluid, marrow or the chorion after immobile liquid is fixing in sample preparation cavity of the present invention through stable pneumatic conveying drying, cell immobile liquid is with suitable speed volatilization, can control Chromosome spread process, significantly improve metaphase chromosome number, ensure the high consistency and repeatability of best Chromosome spread degree and Chromosome spread;
2. the constant humidity air-stream generating device that the present invention adopts, humidity control accuracy is high, and volume is little, has simplified well the inner structure of system, has realized the miniaturization of system;
3. biological sample processing box of the present invention is provided with gas filtration absorption device, and the harmful gas such as methyl alcohol and acetic acid producing in can decontamination of biological sample preparation process, greatly reduces the injury of objectionable impurities to operating personnel and the destruction to environment;
4. energy consumption of the present invention is low, compared with similar products, energy consumption can be reduced to 500W from 1200W;
5. the XYZ three-shaft linkage that the present invention adopts, the sheet that drips that automatically carries out sample operates, and automaticity is high, and efficiency is high;
6. biological sample disposal system of the present invention is easy and simple to handle, and cost of manufacture is low, has good market outlook.
Brief description of the drawings
Fig. 1 is the embodiment of the present invention one biological sample disposal system overall appearance structural representation.
Fig. 2 is the structural representation of the sample preparation cavity of the embodiment of the present invention one.
Fig. 3 is the structural representation of the constant humidity air-stream generating device of the embodiment of the present invention three.
Fig. 4 is the structural representation of the controllable temperature sample cell of the embodiment of the present invention four.
Embodiment
Details are as follows for the preferred embodiments of the present invention:
embodiment mono-:
In the present embodiment, referring to Fig. 1, a kind of biological sample disposal system, comprise system backplane 7, microslide placement platform 21, sample cell 6, biological sample drips sheet devices and sample preparation cavity, microslide placement platform 21 is fixedly installed in system backplane 7, microslide 25 is set on microslide placement platform 21, also comprise control system 15 and man-machine interface 16, control system 15 is single-chip microcomputer, control system 15 is dripped sheet devices by controlling biological sample, pending biological sample is transferred on microslide 25 surfaces, user realizes information interaction by man-machine interface 16 and control system 15, man-machine interface 16 is connected by communication wire with control system 15, by man-machine interface 16, the parameter of sample preparation process is set, according to concrete sample preparation requirement, change method and the flow process of sample preparation, by man-machine interface 16, the procedure information of show sample processing simultaneously, the status information of sensor information and relevant control module, biological sample drips sheet devices and comprises spatial movement mechanism, liquid-transfering device 8 and microslide fetching device 9, the fixed part of spatial movement mechanism is fixedly connected with system backplane 7 by support 14, the bottom of support 14 is fixedly installed in system backplane 7, the action part of spatial movement mechanism is fixedly connected with microslide fetching device 9 with liquid-transfering device 8 respectively, control system 15 is by controlling spatial movement mechanism, the movement locus that the motion parts output of spatial movement mechanism is set, in the time that biological sample experiment starts, make microslide fetching device 9 automatically place microslide 25 on microslide placement platform 21, and liquid-transfering device 8 is also transferred to biological sample the surface of microslide 25 automatically from sample cell 6 automatic suckings, after biological sample is finished dealing with, from microslide placement platform 21, automatic moving is except microslide 25, microslide placement platform 21 is arranged in sample preparation cavity 2, sample preparation cavity 2 is enclosed and is formed the chamber with open topped 29 by shell cavity 28, microslide placement platform 21 is arranged on position under the open topped of counter sample process chambers 2, be also special set temperature control device, humidity conditioner and the air flow controller of being equipped with of sample preparation cavity 2, realize respectively the automatic control to the temperature in the internal chamber of sample preparation cavity 2, humidity and gas velocity by control system 15, sample cell 6 is provided with temperature control equipment, and sample cell 6 is for placing biological sample, and temperature control equipment regulates and controls the temperature in sample cell 6.
In the present embodiment, referring to Fig. 1, system also comprises label machine 17 and barcode scanner 18, label machine 17 is connected with control system 15 signals respectively with barcode scanner 18, application barcode scanner 18 is swept and is read the label of pending biological sample, and sends scanning information to control system 15, and control system 15 is according to the establishing method of biological sample processing and flow process, send label printing instruction to label machine 17, print the label that contains sample and microslide information.In the present embodiment, referring to Fig. 1, label machine 17 is connected with control system 15 by operation circuit with barcode scanner 18, receive and send instruction to control system 15, the label information that application barcode scanner 18 is treated processing sample reads, and communicate with control system 15, establishing method and flow process that control system 15 is processed per sample, abstract factory printer 17 is printed the label that contains the information such as sample and microslide, microslide 25 after realizing sample preparation and finishing is corresponding with processing sample, avoids going wrong.
In the present embodiment, referring to Fig. 1, system also comprises exhaust gas adsorption device 19, by support 14, exhaust gas adsorption device 19 is arranged on to sample preparation cavity, microslide placement platform 21, sample cell 6 and biological sample and drips the top of sheet devices, the harmful gas producing for automatic absorption biological sample processing procedure.
In the present embodiment, referring to Fig. 1, the spatial movement mechanism that biological sample drips sheet devices is XYZ three-shaft linkage device, by X-axis mechanism 3, the mutually orthogonal controlled motion mechanism composition in space between 10 3 mechanism's axis of Y-axis mechanism 4 and Z-axis mechanism, X-axis mechanism 3, Y-axis mechanism 4 and Z-axis mechanism 10 have respectively fixed part and moving part, wherein the fixed part of X-axis mechanism 3 is fixedly installed on the column of support 14, the fixed part of Y-axis mechanism 4 is fixedly installed on the moving part of X-axis mechanism 3, the fixed part of Z-axis mechanism 10 is fixedly installed on the moving part of Y-axis mechanism 4, liquid-transfering device 8 and microslide fetching device 9 are fixedly installed on the moving part of Z-axis mechanism 10, the moving part of the each controlled motion mechanism of XYZ three-shaft linkage device carries out corresponding space line displacement movement by motor independently respectively, under the transmission of the independent exclusive motor in X-axis mechanism 3, the fixed part of the moving part QianYZhou mechanism 4 of X-axis mechanism 3 carries out side-to-side movement, under the transmission of the independent exclusive motor in Y-axis mechanism 4, the fixed part of the moving part traction Z-axis mechanism 10 of Y-axis mechanism 4 seesaws, under the transmission of the independent exclusive motor at Z-axis mechanism 10, the moving part of Z-axis mechanism 10 moves up and down, control each motor of XYZ three-shaft linkage device by control system 15, controlling respectively liquid-transfering device 8 and microslide fetching device 9 moves according to the space path of setting, thereby realize the automatic transporting of microslide 25, place and remove process, and realize the transfer of biological sample, draw and drip and let slip journey.
In the present embodiment, referring to Fig. 1, above XYZ three-shaft linkage device, be fixed with support 14, X-axis mechanism 3 is fixed on the column of support 14, and one end of Y-axis 4 mechanisms is fixed in X-axis mechanism 3.Z-axis mechanism 10 is fixed in Y-axis mechanism 4.XYZ axle is under driven by motor, carry out transmission by screw mandrel, under the transmission of the exclusive motor of X-axis mechanism, Y-axis mechanism carries out side-to-side movement, under the transmission of the exclusive motor of Y-axis mechanism, the motion of Z-axis mechanism before and after carrying out, under the transmission of the exclusive motor of Z-axis mechanism, liquid-transfering device 8 and microslide fetching device 9 move up and down.XYZ three-shaft linkage, has realized microslide 25 and pending sample in three-dimensional motion, and has realized the robotization of sample preparation process.
In the present embodiment, referring to Fig. 1 and Fig. 2, in system backplane 7, fixedly mount microslide heap frame 13 and microslide layer frame 11, in the time that biological sample experiment starts, controlling slide fetching device 9 picks up microslide 25 automatically from microslide heap frame 13, after carrying, pass through again the open topped 29 of sample preparation cavity 2, enter the inside of sample preparation cavity 2, microslide 25 is placed into above slide platforms 21, and after biological sample has been tested, controlling slide fetching device 9 picks up microslide 25 automatically from slide platforms 21, after carrying, pass through again the open topped 29 of sample preparation cavity 2, leave sample preparation cavity 2, microslide 25 is placed into respectively in the equivalent layer frame of microslide layer frame 11, by open topped 29, liquid-transfering device 8 is drawn processing sample add microslide 25 surfaces to from sample cell 6, carry out dispersion treatment.
In the present embodiment, referring to Fig. 1 and Fig. 2, the temperature control equipment of sample preparation cavity 2 and microslide placement platform 21 form sample preparation platform, wherein temperature control equipment is by temperature control element 22, radiating block 23, temperature-dropping fan 24 and temperature sensor 27 form, temperature control element 22 is installed in the middle of slide platforms 21 and radiating block 23, temperature sensor 27 detects the temperature of microslide placement platform 21 in real time, the temperature signal that control system 15 gathers according to temperature sensor 27, the detected value of temperature and setting value are compared, temperature control element 22 is regulated and controled, realize the control of the temperature to microslide placement platform 21 according to the platform temperature of setting.
In the present embodiment, referring to Fig. 2, temperature control element 22 is semiconductor temperature-control element, by heating or the cooling of temperature control element 22, microslide placement platform 21 is heated up or lowers the temperature control.
In the present embodiment, referring to Fig. 1, in the system backplane 7 of sample preparation cavity 2 inside, be provided with rifle head box 5 and de-rifle head device 12, biological sample drips the action part energy automatic loading and unloading sample loading gun head of the spatial movement mechanism of sheet devices, control system 15 is by controlling spatial movement mechanism, realize automatic sampling gun, take arms head, the operation of automatic trip rifle head and mixed liquid automatically, sample loading gun comprises motor, piston and rifle head, the motor of sample loading gun adopts stepper motor, and electric machine main shaft is by driving piston up-down to carry out imbibition and liquid feeding operation.
In the present embodiment, referring to Fig. 1, according to chromosomal sheet operation in classical cytogenetics, by XYZ three-shaft linkage, complete successively following action:
1. microslide fetching device 9 first picks and places microslide 25 on the microslide placement platform 21 that is arranged in sample preparation cavity 2 from microslide heap frame 13;
2. liquid-transfering device 8 pipettes liquid feeding rifle head;
3. the sample loading gun of liquid-transfering device 8 mixes sample operation;
4. sample loading gun is drawn sample;
5. the sample liquid feeding that liquid-transfering device 8 is drawn sample loading gun is to microslide 25 surfaces that are arranged in sample preparation cavity 2;
6. the lip-deep sample of microslide 25 volatilizees under the condition of setting humiture, and chromosome disperses;
7. after sample preparation finishes, microslide fetching device 9 picks and places on microslide layer frame 11 containing the microslide 25 of handling sample, and a sample preparation has circulated, then carries out new sample preparation cycling.
In the present embodiment, referring to Fig. 1 and Fig. 2, biological sample treating apparatus, comprises constant humidity air-stream generating device 1, liquid-transfering device 8, microslide fetching device 9, sample cell 6, exhaust gas adsorption device 19, XYZ three-axis moving device, barcode scanner 18, label machine 17, microslide heap frame 13, microslide layer frame 11, rifle head box 5 and control system 15.Liquid-transfering device 8, by after the sample blending in sample hose, is added drop-wise to microslide 25 surfaces and processes.Microslide fetching device 9 picks and places microslide 25 in sample preparation cavity 2 from microslide heap frame 13, processes, and handles, then microslide 25 is picked and placeed on microslide layer frame 11.XYZ three-axis moving device control liquid-transfering device 8 and microslide fetching device 9 are along the motor performance of X-axis, Y-axis and three directions of Z axis.Three parts link, and complete the automatic processing procedure of sample.This embodiment biological sample treating apparatus is specially adapted to CYTOGENETIC ANALYSIS OF ONE, realizes chromosome and drip the robotization of sheet process, improves analysis efficiency, ensures the quality of sample preparation.Barcode scanner 18 is for the bar code on scanning samples pipe, and control system 15 prints the positional information of the bar code information of sample hose, sample hose positional information, final microslide by label machine 17, be attached on microslide 25.
embodiment bis-:
The present embodiment and embodiment mono-are basic identical, and special feature is:
In the present embodiment, exhaust gas adsorption device 19 is made up of filtrator and air exhauster, realize the gas producing in automatic absorbing Bioexperiment process, in filtrator, be provided with absorbent filtering layer, the adsorbent adopting is soda lime, exhaust gas adsorption device 19 is positioned at the top of sample processing system, is made up of blower fan, adsorbent and shell.Processing sample is generally through methyl alcohol and the fixing cell suspension of processing of acetic acid, drip in the sample of sheet processing and contain the volatile organic solvent such as methyl alcohol and acetic acid, in processing procedure, can produce volatile methyl alcohol and acetic acid escaping gas, be discharged into internal system, to installing itself, operating personnel and environment exist adverse effect.The blower fan of exhaust gas adsorption device 19 is pumped into the air that contains escaping gas the inside of exhaust gas adsorption device, the flow through surface of adsorbent, the harmful gas such as methyl alcohol and acetic acid in adsorbent adsorption gas flow, give off again clean air-flow, realize the object of air purification, the escaping gas effectively producing in adsorption sample processing procedure, eliminates its harm to environment and operator ' s health.The inner air-flow of device is pumped into adsorbent equipment by blower fan, and the air-flow after filtration can be discharged to device outside.
embodiment tri-:
The present embodiment and previous embodiment are basic identical, and special feature is:
In the present embodiment, referring to Fig. 3, the humidity conditioner of sample preparation cavity 2 and air flow controller are by being integrated into constant humidity air-stream generating device 1 in the outside of sample preparation cavity 2, constant humidity air-stream generating device 1 is the cavity of a sealing, sample preparation cavity 2 has air intake opening 26, the air intake opening 26 of constant humidity air-stream generating device 1 is communicated with by air delivering pipeline with the gas outlet 61 of constant humidity air-stream generating device 1, in the interior flow control that air-stream generating device 60 is set realizes as the air flow controller of sample preparation cavity 2 delivery air of constant humidity air-stream generating device 1, air-stream generating device 60 is air pump, constant humidity air-stream generating device 1 is mainly by humidification water pond 51, water heating elements 53, water temperature sensor 54, condenser 55, dehumidifying semiconductor 58, heat-conducting block 56, cooling fan 57 and Temperature Humidity Sensor 59 form, control system 15 is controlled water heating elements 53 water body 52 storing in humidification water pond 51 is heated and manufactures water vapor, water temperature sensor 54 detects water body 52 temperature in humidification water pond 51 in real time, control system 15 is according to the comparative result of the temperature detection value of water and setting value, water heating elements 53 is regulated and controled, realize the accurate control of water temperature, extraneous air is under the driving of air-stream generating device 60, enter the inside cavity of constant humidity air-stream generating device 1, the air-flow of the specified moisture that the present embodiment produces constant humidity air-stream generating device 1 imports in sample preparation cavity 2, for sample preparation provides best environmental baseline, guarantee the Disposal quality of sample, the flow through surface of the water body 52 storing in humidification water pond 51, carry water vapor and after humidification, entered the pipeline of condenser 55, condensation goes out part moisture, thereby realize the regulation and control to airflow humidity, flow through successively again dehumidifying the exsiccation region of semiconductor 58 and the measurement point of Temperature Humidity Sensor 59, finally flow out from gas outlet 61, enter sample preparation cavity 2 inside, cooling fan 57 carries out cooling by heat-conducting block 56 to dehumidifying semiconductor 58, the heat that the semiconductor 58 that makes to dehumidify produces is discharged in environment through heat-conducting block 56 and cooling fan 57 successively, guarantee the balance of heat and the lasting normal work of dehumidifying semiconductor 58, the temperature-humidity signal that control system 15 gathers according to Temperature Humidity Sensor 59, the humiture testing result of air-flow is sent to control system 15, the detected value of humiture and setting value are compared, duty to dehumidifying semiconductor 58 regulates and controls, realize the humidity control of the air-flow in the exsiccation region to the dehumidifying semiconductor 58 of flowing through, thereby accurately control the humidity of effluent stream, guarantee that the humidity of the air-flow that constant humidity air-stream generating device 1 produces is in setting range.
In the present embodiment, referring to Fig. 3, water heating elements 53 is semiconductor heating element, by the heating of water heating elements 53, controls the humidity of the air-flow on humidification water pond 51 surfaces of flowing through.Water after intensification plays humidification to the air-flow that pumps into cavity, and airflow humidity is increased to and is set on humidity.
embodiment tetra-:
The present embodiment and previous embodiment are basic identical, and special feature is:
In the present embodiment, referring to Fig. 4, controllable temperature sample cell 6 is arranged in system backplane 7, the temperature control equipment of controllable temperature sample cell 6 comprises temperature sensor 69, temperature controller 67, radiator 66 and cooling blower 65, sample cell casing 68 tops of controllable temperature sample cell 6 are provided with the sunk type sample well 70 of multiple openings, be used for placing pending biological sample, in sunk type sample well 70, place biological sample, temperature sensor 69 detects the temperature of the biological sample of the inside of sample cell casing 68 in real time, the temperature signal that control system 15 gathers according to temperature sensor 69, the detected value of temperature and setting value are compared, temperature controller 67 is regulated and controled, realize the temperature control to sample cell casing 68.The heat producing in temperature controller 67 courses of work is discharged in environment through radiator 66 and blower fan 65, guarantees the lasting normal work of balance and the temperature control element of heat.In the present embodiment, referring to Fig. 4, temperature controller 67 is semiconductor temperature-control element, and temperature controller 67 is installed in the middle of sample cell casing 68 and radiator 66, by heating or the cooling of temperature controller 67, the sample in sample cell casing 68 is heated up or lowers the temperature control.
embodiment five:
The present embodiment and previous embodiment are basic identical, and special feature is:
In the present embodiment, microslide fetching device 9 comprises negative pressure pump, pressure transducer, microslide suction nozzle, the pressure signal that control system 15 gathers according to pressure transducer, the detected value of pressure and setting value are compared, negative pressure pump is regulated and controled, realize work method control to microslide suction nozzle, and control biological sample by interlock and drip the spatial movement mechanism that sheet devices comprises, show the automatic operation of getting sheet and film releasing of microslide 25.
By reference to the accompanying drawings the embodiment of the present invention is illustrated above; but the invention is not restricted to above-described embodiment; can also make multiple variation according to the object of innovation and creation of the present invention; the change made under all Spirit Essences according to technical solution of the present invention and principle, modification, substitute, combination, simplify; all should be equivalent substitute mode; as long as goal of the invention according to the invention; only otherwise deviate from know-why and the inventive concept of biological sample disposal system of the present invention, all belong to protection scope of the present invention.
Claims (16)
1. a biological sample disposal system, comprise system backplane (7), microslide placement platform (21), sample cell (6), biological sample drips sheet devices and sample preparation cavity, described microslide placement platform (21) is fixedly installed in described system backplane (7), microslide (25) is set on described microslide placement platform (21), it is characterized in that: also comprise control system (15) and man-machine interface (16), described control system (15) is dripped sheet devices by controlling described biological sample, pending biological sample is transferred on described microslide (25) surface, user realizes information interaction by described man-machine interface (16) and described control system (15), described biological sample drips sheet devices and comprises spatial movement mechanism, liquid-transfering device (8) and microslide fetching device (9), the fixed part of described spatial movement mechanism is fixedly connected with described system backplane (7) by support (14), the bottom of described support (14) is fixedly installed in described system backplane (7), the action part of described spatial movement mechanism is fixedly connected with described microslide fetching device (9) with described liquid-transfering device (8) respectively, described control system (15) is by the described spatial movement of control mechanism, the movement locus that the motion parts output of described spatial movement mechanism is set, in the time that biological sample experiment starts, make described microslide fetching device (9) to the upper described microslide (25) of automatically placing of described microslide placement platform (21), and liquid-transfering device (8) is also transferred to biological sample automatic sucking from the sample hose of described sample cell (6) on the surface of described microslide (25) automatically, after biological sample is finished dealing with, from described microslide placement platform (21), automatic moving is except described microslide (25), described microslide placement platform (21) is arranged in sample preparation cavity (2), described sample preparation cavity (2) is enclosed and is formed the have open topped chamber of (29) by shell cavity (28), described microslide placement platform (21) is arranged on position under the open topped of corresponding described sample preparation cavity (2), also be equipped with specially set temperature control device for described sample preparation cavity (2), humidity conditioner and air flow controller, realize respectively the temperature in the internal chamber of described sample preparation cavity (2) by described control system (15), the automatic control of humidity and gas velocity, described sample cell (6) is provided with temperature control equipment, and described sample cell (6) is for placing biological sample, and described temperature control equipment regulates and controls the temperature in described sample cell (6).
2. biological sample disposal system according to claim 1, it is characterized in that: system also comprises label machine (17) and barcode scanner (18), described label machine (17) is connected with described control system (15) signal respectively with described barcode scanner (18), applying described barcode scanner (18) sweeps and reads the label of pending biological sample, and send scanning information to described control system (15), described control system (15) is according to the establishing method of biological sample processing and flow process, send label printing instruction to described label machine (17), the label that printing contains sample and microslide information.
3. according to biological sample disposal system described in claim 1 or 2, it is characterized in that: system also comprises exhaust gas adsorption device (19), by described support (14), described exhaust gas adsorption device (19) is arranged on to described sample preparation cavity, described microslide placement platform (21), described sample cell (6) and described biological sample and drips the top of sheet devices, the harmful gas producing for automatic absorption biological sample processing procedure.
4. biological sample disposal system according to claim 3, it is characterized in that: described exhaust gas adsorption device (19) is made up of filtrator and air exhauster, realize the gas producing in automatic absorbing Bioexperiment process, in described filtrator, be provided with absorbent filtering layer, the adsorbent of employing is the potpourri of any one or any several compositions in soda lime, calcium lime and acticarbon.
5. according to biological sample disposal system described in claim 1 or 2, it is characterized in that: the spatial movement mechanism that described biological sample drips sheet devices is XYZ three-shaft linkage device, by X-axis mechanism (3), the mutually orthogonal controlled motion mechanism composition in space between (10) three mechanism's axis of Y-axis mechanism (4) and Z-axis mechanism, described X-axis mechanism (3), described Y-axis mechanism (4) and described Z-axis mechanism (10) have respectively fixed part and moving part, the fixed part of wherein said X-axis mechanism (3) is fixedly installed on the column of described support (14), the fixed part of described Y-axis mechanism (4) is fixedly installed on the moving part of described X-axis mechanism (3), the fixed part of described Z-axis mechanism (10) is fixedly installed on the moving part of described Y-axis mechanism (4), described liquid-transfering device (8) and described microslide fetching device (9) are fixedly installed on the moving part of described Z-axis mechanism (10), the moving part of the each controlled motion mechanism of described XYZ three-shaft linkage device carries out corresponding space line displacement movement by motor independently respectively, separately under the transmission of the exclusive motor of described X-axis mechanism (3), the fixed part that the moving part of described X-axis mechanism (3) leads described Y-axis mechanism (4) carries out side-to-side movement, separately under the transmission of the exclusive motor of described Y-axis mechanism (4), the fixed part that the moving part of described Y-axis mechanism (4) draws described Z-axis mechanism (10) seesaws, separately under the transmission of the exclusive motor of described Z-axis mechanism (10), the moving part of described Z-axis mechanism (10) moves up and down, control each motor of XYZ three-shaft linkage device by described control system (15), controlling respectively described liquid-transfering device (8) and described microslide fetching device (9) moves according to the space path of setting, thereby realize the automatic transporting of described microslide (25), place and remove process, and realize the transfer of biological sample, draw and drip and let slip journey.
6. according to biological sample disposal system described in claim 1 or 2, it is characterized in that: the temperature control equipment of described sample preparation cavity (2) and described microslide placement platform (21) form sample preparation platform, wherein said temperature control equipment is by temperature control element (22), radiating block (23), temperature-dropping fan (24) and temperature sensor (27) composition, described temperature sensor (27) detects the temperature of described microslide placement platform (21) in real time, the temperature signal that described control system (15) gathers according to described temperature sensor (27), the detected value of temperature and setting value are compared, described temperature control element (22) is regulated and controled, realize the control of the temperature to described microslide placement platform (21).
7. biological sample disposal system according to claim 6, it is characterized in that: described temperature control element (22) is PTC heating element or semiconductor temperature-control element, by heating or the refrigeration of described temperature control element (22), described microslide placement platform (21) is heated up or lowers the temperature control.
8. according to biological sample disposal system described in claim 1 or 2, it is characterized in that: the humidity conditioner of described sample preparation cavity (2) and air flow controller are by being integrated into constant humidity air-stream generating device (1) in the outside of described sample preparation cavity (2), described constant humidity air-stream generating device (1) is the cavity of a sealing, described sample preparation cavity (2) has air intake opening (26), the air intake opening (26) of described constant humidity air-stream generating device (1) is communicated with by air delivering pipeline with the gas outlet (61) of described constant humidity air-stream generating device (1), air-stream generating device (60) is set in described constant humidity air-stream generating device (1) and realizes the flow control of delivery air as the air flow controller of described sample preparation cavity (2), described air-stream generating device (60) is blower fan or air pump, described constant humidity air-stream generating device (1) is mainly by humidification water pond (51), water heating elements (53), water temperature sensor (54), condenser (55), dehumidifying semiconductor (58), heat-conducting block (56), cooling fan (57) and Temperature Humidity Sensor (59) composition, described control system (15) is controlled described water heating elements (53) water body (52) storing in described humidification water pond (51) is heated and manufactures water vapor, described water temperature sensor (54) detects water body (52) temperature in described humidification water pond (51) in real time, described control system (15) is according to the comparative result of the temperature detection value of water and setting value, described water heating elements (53) is regulated and controled, realize water temperature is controlled, extraneous air is under the driving of described air-stream generating device (60), enter the inside cavity of described constant humidity air-stream generating device (1), the flow through surface of the water body (52) storing in described humidification water pond (51), carry water vapor and after humidification, entered the pipeline of described condenser (55), flow through successively again the exsiccation region of described dehumidifying semiconductor (58) and the measurement point of described Temperature Humidity Sensor (59), finally flow out from described gas outlet (61), enter described sample preparation cavity (2) inside, described cooling fan (57) carries out cooling by described heat-conducting block (56) to described dehumidifying semiconductor (58), the heat that described dehumidifying semiconductor (58) is produced is discharged in environment through described heat-conducting block (56) and described cooling fan (57) successively, the temperature-humidity signal that described control system (15) gathers according to Temperature Humidity Sensor (59), the detected value of humiture and setting value are compared, duty to described dehumidifying semiconductor (58) regulates and controls, realize the humidity control of the air-flow in the exsiccation region to the described dehumidifying semiconductor (58) of flowing through.
9. biological sample disposal system according to claim 8, it is characterized in that: described water heating elements (53) is PTC heating element or semiconductor temperature-control element, by the heating of described water heating elements (53), control the humidity of the air-flow on described humidification water pond (51) surface of flowing through.
10. according to biological sample disposal system described in claim 1 or 2, it is characterized in that: at the upper fixed installation of described system backplane (7) microslide heap frame (13) and microslide layer frame (11), in the time that biological sample experiment starts, controlling described slide fetching device (9) picks up microslide (25) automatically from described microslide heap frame (13), through carrying after again by the open topped (29) of described sample preparation cavity (2), enter the inside of described sample preparation cavity (2), microslide (25) is placed into described slide platforms (21) above, and after biological sample has been tested, controlling described slide fetching device (9) picks up microslide (25) automatically from described slide platforms (21), through carrying after again by the open topped (29) of described sample preparation cavity (2), leave described sample preparation cavity (2), microslide (25) is placed into respectively in the equivalent layer frame of described microslide layer frame (11).
11. according to biological sample disposal system described in claim 1 or 2, it is characterized in that: described controllable temperature sample cell (6) is arranged in system backplane (7), the temperature control equipment of described controllable temperature sample cell (6) comprises temperature sensor (69), temperature controller (67), radiator (66) and cooling blower (65), sample cell casing (68) top of described controllable temperature sample cell (6) is provided with the sunk type sample well (70) of multiple openings, in described sunk type sample well (70), place biological sample, described temperature sensor (69) detects the internal temperature of described sample cell casing (68) in real time, the temperature signal that described control system (15) gathers according to described temperature sensor (69), the detected value of temperature and setting value are compared, described temperature controller (67) is regulated and controled, realize the internal temperature control to described sample cell casing (68).
12. according to biological sample disposal system described in claim 11, it is characterized in that: described temperature controller (67) is PTC heating element or semiconductor temperature-control element, by heating or the refrigeration of described temperature controller (67), the sample in described sample cell casing (68) is heated up or lowers the temperature control.
13. according to biological sample disposal system described in claim 1 or 2, it is characterized in that: in system backplane (7), be provided with rifle head box (5) and de-rifle head device (12), described biological sample drips the action part energy automatic loading and unloading sample loading gun of the spatial movement mechanism of sheet devices, described control system (15) is by the described spatial movement of control mechanism, realize automatic sampling gun automatically take arms head, automatic trip rifle head, mixed liquid and add imbibition operation, described sample loading gun comprises motor, piston and rifle head, and described electric machine main shaft is by driving piston up-down to carry out imbibition and liquid feeding operation.
14. according to biological sample disposal system described in claim 13, it is characterized in that: the motor of described sample loading gun adopts stepper motor, direct current generator or reducing motor.
15. according to biological sample disposal system described in claim 1 or 2, it is characterized in that: described microslide fetching device (9) comprises negative pressure pump, pressure transducer, microslide suction nozzle, the pressure signal that described control system (15) gathers according to described pressure transducer, the detected value of pressure and setting value are compared, described negative pressure pump is regulated and controled, realize the work method control to described microslide suction nozzle, and drip by the described biological sample that links the spatial movement mechanism that sheet devices comprises, the automatic operation of getting sheet and film releasing of existing microslide (25).
16. according to biological sample disposal system described in claim 1 or 2, it is characterized in that: described control system (15) is any one in motion control card, single-chip microcomputer, computing machine, programmable controller.
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