CN103278625A

CN103278625A - Closed type chromatography test paper detection device and application method of closed type chromatography test paper detection device

Info

Publication number: CN103278625A
Application number: CN2013101589983A
Authority: CN
Inventors: 周中人; 唐雪明; 姜杰; 周可仁
Original assignee: QUICKING BIOTECH CO Ltd
Current assignee: QUICKING BIOTECH CO Ltd
Priority date: 2013-04-28
Filing date: 2013-04-28
Publication date: 2013-09-04
Also published as: CN103529201A; CN103529201B

Abstract

The invention discloses a closed type chromatography test paper detection device and an application method of the closed type chromatography test paper detection device. The closed type chromatography test paper detection device comprises a solution tube, a connection tube and a test paper tube, wherein the tube body bottom of the solution tube is provided with a bottom structure with shear marks; the inner wall circumference surface of the tube body of the solution tube is provided with two grooves, one groove allows repeated opening of a cover of the solution tube, and the other groove reversely hooks the cover to form the closed environment; the inner circular wall of a counter bore-shaped connector of the connection tube matched with the solution tube is provided with a convex sealing ring, the convex sealing ring is matched with the groove of the solution tube and then hooks reversely to form the closed environment; the bottom of the connector of the connection tube, for insertion of the solution tube, is provided with a structure interacting with the bottom structure of the solution tube to release solution; the connector between the connection tube and the test paper tube is internally provided with the convex sealing ring, the convex sealing ring is matched with the groove outside the test paper tube and then reversely hooks to form the closed environment; and moreover, other solution tubes can be stacked and sleeved on the solution tube so as to form multiple sleeves. The closed type chromatography test paper detection device is small in volume, can realize complete closure, and can completely prevent influence and pollution to the environment caused by the sample in the chromatography test paper sample solution.

Description

A kind of enclosed chromatographic test paper pick-up unit and using method thereof

Technical field

The present invention relates to a kind of chromatographic test paper pick-up unit, relate in particular to a kind of enclosed chromatographic test paper pick-up unit; In addition, the invention still further relates to the using method of this device.

Background technology

Charlton is in effluent chromatographic test paper technology (the Lateral Flow of invention in 1988, US6,485,982) caused the immunology diagnosis revolution, this diagnostic techniques has been simplified sample by the mode of chromatographic test paper and has been added step, has realized unprecedented simple, quick, accurate and cheap by the reaction of the solid-phase immunity on nitrocellulose filter simultaneously.Colloidal gold immune chromatography test is generalized to widely used fast medical external diagnosis reagent subsequently, also has been generalized to food security and bio-safety fast detecting field subsequently.The biochemical test paper of other dry types also begins to adopt the chromatographic test paper mode simultaneously.In the test item of these chromatographic test papers, the part detection material can produce damaging effect to operating personnel and environment, detects dioxin etc. as the anthrax cause of disease.Therefore the chromatography detecting test paper of this class detected object needs supporting closed pick-up unit.

General hand-held test strips and the two kinds of forms of plastics cartridge packing of adopting of at present common chromatographic test paper.The production technology of hand-held test strips is simple, and packaging volume is little, the storage convenient transportation.It only need insert of regulation in the sample solution of certain depth in use, and the just automatic chromatography of solution is climbed up test strips, goes out the result in short time showing.But after detection is finished, be full of residual sample solution on the whole test strips substantially, this residual solution may contaminated environment and operating personnel in subsequent operation.Therefore using the main detected object of immune chromatography test paper of hand-held test strips form at present is human or animal's urine, has communicable clinical sample and does not generally adopt this mode.

The chromatographic test paper product of plastics cartridge packing is the main flow of existing market.Three kinds of perforates are generally arranged on the plastics cartridge, and a kind of is sample viewing window, is used for observing the reaction result of chromatographic test paper; A kind of is that sample solution adds the hole; A kind of is that bleeder vent is used for carrying out the sample solution on the rapid draing test paper.These three kinds of perforates may be exposed to the sample solution that is added on the test paper in the air, possible contaminated environment and operating personnel.But compare hand-held test strips, significantly reduced opportunities for contamination.

American I nverness company used a kind of detect urine sample early pregnancy pen type plastics cartridge, the view window of this kind cartridge is replaced by LCDs or transparent sealed plastic sheet, the interpolation hole of sample solution is by solution absorbing rod replacement automatically, and after sample solution enters absorbing rod, this absorbing rod can be connected by a plastic jacket cover, can fully sample solution be sealed in plastics cartridge inside.

Chromatographic test paper is widely used in drug addict's the urine fast detecting at present.The plastics cartridge that the main detection test paper packaged form of drugs detection chromatographic test paper is the plug-in type headgear.In this packaged form, chromatographic test paper whole (containing view window) can be sealed by transparent plastic sheet, sample adds part and stretches out to insert solution absorption sample, drawing at sample has after finishing a plug-in type headgear that the sample of test paper is added part to entangle, so this class plastics cartridge can completely cut off the sample solution that contains Poison substantially to environment and operating personnel's pollution.

From polymerase chain reaction (the Polymerase Chain Reaction of U.S. Cetus company in 1985, PCR) realized that since the specific amplification of nucleic acid, this technology just is widely used in eqpidemic disease cause of disease detection range because having high sensitivity, high specific and characteristics of high efficiency.But the high concentration cause of disease nucleotide sequence that is amplified is easy to contaminated air, test tool and water in the subsequent operation process, thereby causes the false positive results of subsequent detection sample.Therefore in the penetration and promotion of detection of nucleic acids, also need to develop closed pick-up unit and method.

Solve the pollution problem of nucleic acid amplification product when detecting, mainly contain two kinds of strategies.First kind is to build airtight environment in the process that detects nucleic acid amplification product, as: electrophoresis carries out in airtight negative pressure room, the overall process of real-time fluorescence PCR is not opened reaction tube, but these methods all need strict experiment condition and expensive experimental equipment, are not suitable for being popularized for the user of basic unit.Second kind is to mix dUTP in nucleic acid amplification reaction, uses UNG enzyme Processing Test utensil and environment before the nucleic acid amplification after reaction is finished and next time, but this method complex operation, and have certain contamination probability, limited the application of this strategy.

Gerdes etc. (US2004/0110167) are applied to the effluent chromatographic technique in the detection of nucleic acid amplification product, use for detection of nucleic acids in basic unit and have brought hope.Pollute for fear of producing in nucleic acid effluent chromatography process, best selection is to use device that the chromatography process is closed.Look after one's family and wait (CN1888902) to invent a kind of closed nucleic acid effluent chromatography pick-up unit forever, its structure comprises shell and inner box, comprise chromatography dilution, nucleic acid amplification product and chromatograph test strip in the inner box, blade pierces diluted liquid tube when shell is closed in the inner box and nucleic acid amplification pipe, be imported into the sample pad of chromatograph test strip after two kinds of liquid mix, realize the immunochromatography chromogenic reaction.But the shortcoming of this device is: 1, device volume is big, is not suitable for large-scale production and the transportation of finished product; 2, the test strips in the device is installed complexity, is not suitable for the test paper Assembling Production of scale; 3, after this device is restarted use, can be by easily simple and do not reopen with having vestige, so just relatively realized the sealing of nucleic acid amplification product, if be not intended to open the device that reacted by the people, the pollution of amplified production is just inevitable; 4, can only finish the detection of single reactant liquor in this device, and can't detect a plurality of reactant liquors, namely can't finish the detection of multiple sample in the mode of a plurality of reactant liquors a test strips.5, the release of the liquid in this device is to accomplish by the broken reaction tube of the pre-aligned metal blade of laying and acupuncture in injection moulding process and diluted liquid tube.This is unfavorable for environmental protection, difficulty and the cost of the injection moulding production that also increases.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of enclosed chromatographic test paper pick-up unit of brand new, the enclosed chromatographic test paper pick-up unit of being formed by three small and exquisite assembled of volume, the device of assembling out can be realized complete closed, can block the sample of chromatographic test paper fully to operating personnel's harm and the pollution of environment.This apparatus structure simply is easy to injection moulding production in batches, and the batch assembling that also is easy to test strips is produced; Can be implemented in the device and can detect several samples solution by the mode of physical combination; The release of sample liquid is without any need for metal parts in the device.The present invention also provides the using method of this device.

For solving the problems of the technologies described above, the present invention takes following technical scheme:

In one aspect of the invention, provide a kind of enclosed chromatographic test paper pick-up unit, comprise solution conduit, connecting pipe and test paper pipe;

Described solution conduit comprises solution conduit body and solution conduit lid; Described solution conduit inboard wall of tube body periphery is provided with two grooves up and down, is respectively inner first groove of solution conduit, inner second groove of solution conduit; The periphery of described solution conduit lid is provided with the raised seals ring, inner first groove of this solution conduit lid periphery raised seals ring and solution conduit, inner second groove of solution conduit can both fitted seal, inner first groove of solution conduit can allow the solution conduit lid to repeat to open, inner second groove of solution conduit then reverse barb is lived the solution conduit lid, make it form enclosed environment in the disposable back, position that is pressed into, be not easy to be opened again; Described solution conduit body periphery is provided with the solution conduit exterior groove, can cooperate with the raised seals ring established in the connecting pipe corresponding interface to form reverse overhead structure, forms enclosed environment and is not easy to be opened; Described solution conduit body bottom is provided with polycrystalline substance, and the bottom cut channel is established in its neighboring, and when polycrystalline substance was subjected to certain acting force, it broke away from from the fracture of bottom cut channel, and the sample solution that is divided in advance this moment in the solution conduit can flow out from the fracture slit;

Described test paper pipe is the hollow elongated tubular of an end opening; The test paper pipe is provided with test paper pipe exterior groove at the interface position of inserting connecting pipe, and this exterior groove cooperates oppositely barb formation enclosed environment of back with the test paper pipe raised seals ring that the connecting pipe inwall is established, be not easy to be opened again;

Described connecting pipe is provided with the counterbore shape interface of one or more and described solution conduit lower tube body profile coupling; Be provided with solution conduit raised seals ring in the described counterbore shape interface, can cooperate with the solution conduit exterior groove of inserting interface to form reverse overhead structure, formation enclosed environment and be not easy to be opened again; Also be provided with interface one or more and test paper pipe coupling on this connecting pipe, be provided with test paper pipe raised seals ring in this interface, this test paper pipe raised seals ring fits in reverse barb hermetically-sealed construction with the test paper pipe exterior groove of inserting interface and is not easy to be opened; Connecting pipe counterbore shape interface bottom is provided with the solution releasing structure, and it gives specific function power to the solution conduit polycrystalline substance can be with its fracture disengaging, and solution discharges from solution conduit; Connecting pipe solution releasing structure bottom is provided with solution channel, and the liquid that solution conduit discharges will flow to the sample solution reception area of the chromatographic test paper in the test paper pipe through solution channel.

Further, described test paper pipe distal portion is provided with annular groove, when firmly acquiring a certain degree, can be convenient to that test sample is carried out abatement of pollution and handle from the annular groove test paper pipe that fractures; Described test paper tube opening end is provided with test paper pipe projection draw-in groove, blocks when being used for test paper is installed and fixing test paper, and test paper tube opening bottom face is provided with test paper pipe projection swash plate; In connecting pipe inside, the connecting portion that is positioned at test paper pipe matched interfaces and solution conduit coupling counterbore shape interface is provided with the connecting pipe slope, when the test paper pipe inserts connecting pipe, this test paper pipe projection swash plate will be by the top certain angle, and test paper is held up behind the certain altitude near the connecting pipe slope.

Further, described solution conduit polycrystalline substance is made as bottom protrusion, and the periphery of this bottom protrusion is provided with solution conduit bottom cut channel, when this bottom protrusion is subjected to certain acting force, it breaks away from from the fracture of bottom cut channel, and the sample solution that is divided in advance this moment in the solution conduit can flow out from the fracture slit;

Described connecting pipe bottom solution releasing structure is made as for the solution conduit bottom protrusion and inserts and chimeric pit, and this pit can interact with the solution conduit bottom protrusion, and the solution of solution conduit is discharged; Described solution channel adopts bottom cut channel sheet, and it is two separate space with connecting pipe counterbore shape interface and test paper interface tube partition; When bottom cut channel sheet was subjected to roof pressure, it began to rupture slit formation solution channel from the position that cut channel is arranged, and the liquid that discharges when solution conduit will be through flowing to the sample solution reception area of the chromatographic test paper in the test paper pipe herein.

Further, described connecting pipe bottom cut channel sheet is circle or the square plate of band wire or point-like cut channel, and the cut channel position material thickness of this bottom cut channel sheet lacks 0.05-0.5mm than the thickness at other positions; When this bottom cut channel sheet was subjected to pressing, the mechanics tolerance value at cut channel position was low and begin fracture from certain position of cut channel than other positions; When for a long time stressed, bottom cut channel sheet has the position complete rupture of cut channel;

Described solution conduit bottom cut channel is wire or point-like, and the material thickness at cut channel position lacks 0.05-0.5mm than the thickness at other positions; When the solution conduit bottom protrusion was subjected to specific function power, the mechanics tolerance value at cut channel position was low than other positions, so bottom bottom protrusion and the solution conduit will rupture from the cut channel position in the junction;

Described solution conduit bottom protrusion and described connecting pipe bottom pit are the mutual embedded structure of in-line or cruciform or other shapes; Inner first groove of described solution conduit, inner second groove of solution conduit, solution conduit exterior groove and test paper pipe exterior groove are annular groove.

Further, described solution conduit top of closure is provided with a counterbore shape cavity, can insert another solution conduit lower tube body and form the stack sleeve structure in this counterbore shape cavity; Described counterbore shape cavity bottom is provided with the solution releasing structure, and solution releasing structure bottom is provided with solution channel; The internal face of solution conduit lid counterbore shape cavity is provided with the raised seals ring, and this raised seals ring cooperates the back to form reverse barb enclosed construction with the exterior groove of another solution conduit of inserting lid counterbore shape cavity, is not easy to be opened again.

Further, described solution conduit polycrystalline substance is bottom protrusion, the solution releasing structure of the counterbore shape cavity of described solution conduit lid is for inserting and chimeric pit for the solution conduit bottom protrusion, and the bottom pit of the counterbore shape cavity of described solution conduit bottom protrusion and described solution conduit lid is the mutual embedded structure of in-line or cruciform or other shapes; Described solution channel adopts bottom cut channel sheet, and when bottom cut channel sheet was subjected to roof pressure, it began to rupture slit formation solution channel from the position that cut channel is arranged; This bottom cut channel sheet is circle or the square plate of band wire or point-like cut channel, and cut channel position material thickness lacks 0.05-0.5mm than the thickness at other positions; When this bottom cut channel sheet was subjected to pressing, the mechanics tolerance value at cut channel position was low and begin fracture from certain position of cut channel than other positions; When for a long time stressed, this bottom cut channel sheet has the position complete rupture of cut channel.

Further, described solution conduit polycrystalline substance is provided with the bottom cut channel; Connecting pipe bottom solution releasing structure by bossing and on every side set solution channel hole form; Bossing is replaced the solution conduit polycrystalline substance, when the solution conduit polycrystalline substance is subjected to acting force that bossing replaces, it breaks away from from the fracture of bottom cut channel, the sample solution that is divided in advance this moment in the solution conduit can flow out from the fracture slit, and the sample solution reception area of the chromatographic test paper of the solution channel orifice flow by the connecting pipe bottom in the test paper pipe.

In another aspect of this invention, provide a kind of solution conduit, described solution conduit comprises solution conduit body and solution conduit lid; Described solution conduit inboard wall of tube body periphery is provided with two grooves up and down, is respectively inner first groove of solution conduit, inner second groove of solution conduit; The periphery of described solution conduit lid is provided with the raised seals ring, inner first groove of this raised seals ring and solution conduit, inner second groove of solution conduit can both fitted seal, inner first groove of solution conduit can allow the solution conduit lid to repeat to open, inner second groove of solution conduit then reverse barb is lived the solution conduit lid, make it form enclosed environment in the disposable back, position that is pressed into, be not easy to be opened again.

Further, described solution conduit body periphery is provided with exterior groove, can cooperate to form reverse overhead structure formation enclosed environment and be not easy to be opened again with the raised seals ring of the round tube inner wall of some coupling design; Described solution conduit body bottom is provided with polycrystalline substance, this polycrystalline substance and solution conduit body base plane junction are provided with solution conduit bottom cut channel, when polycrystalline substance is subjected to certain acting force, it and junction, solution conduit bottom will break away from from the cut channel fracture of solution conduit bottom, and the sample solution that is divided in advance this moment in the solution conduit can flow out from the fracture slit; Described solution conduit bottom cut channel is wire or point-like, and the material thickness at cut channel position lacks 0.05-0.5mm than the thickness at other positions; When solution conduit polycrystalline substance and solution conduit junction were stressed, the torsion tolerance value at cut channel position was low than other positions, so polycrystalline substance and solution conduit junction will be from the cut channel position fractures of solution conduit bottom cut channel.

Further, described solution conduit top of closure is provided with a counterbore shape cavity, can insert another solution conduit bottom body in this counterbore shape cavity; The internal face of solution conduit lid counterbore shape cavity is provided with the raised seals ring, and this raised seals ring cooperates the back to form reverse barb enclosed construction with the exterior groove of inserting another solution conduit of lid counterbore shape cavity, is not easy to be opened again; Described counterbore shape cavity bottom is provided with for the solution conduit polycrystalline substance and inserts and chimeric solution releasing structure, and solution releasing structure bottom is provided with solution channel.

Further, described solution conduit polycrystalline substance is bottom protrusion, and described solution releasing structure is for inserting and chimeric pit for the solution conduit bottom protrusion, and described solution conduit bottom protrusion and described pit are the mutual embedded structure of in-line or cruciform or other shapes; Described solution channel adopts bottom cut channel sheet, and when bottom cut channel sheet was subjected to roof pressure, it began to rupture slit formation solution channel from the position that cut channel is arranged;

Inner first groove of described solution conduit, inner second groove of solution conduit, solution conduit exterior groove are annular groove;

Described cover bottom cut channel sheet is circle or the square plate of band wire or point-like cut channel, and cut channel position material thickness lacks 0.05-0.5mm than the thickness at other positions; When this bottom cut channel sheet was subjected to pressing, the tension force tolerance value at cut channel position was low than other positions, and therefore this bottom cut channel sheet begins fracture from certain position of cut channel.

In another aspect of this invention, also provide a kind of using method of described enclosed chromatographic test paper pick-up unit, comprise the steps:

Step 1, test paper inserts and is installed in the test paper pipe, and test paper pipe projection draw-in groove blocks test paper, and the related test paper of test paper pipe injects in the interface of connecting pipe and its coupling, and test paper pipe exterior groove cooperates the reverse barb sealing in back to extract with test paper pipe raised seals ring;

Step 2 is put into sample solution in the solution conduit body, and the solution conduit lid is covered in the solution conduit body, inner first groove fit of solution conduit lid periphery raised seals ring and solution conduit;

Step 3 is inserted above-mentioned solution conduit in the counterbore shape interface of connecting pipe, when solution conduit is inserted into the end, makes the solution conduit exterior groove cooperate the formation overhead structure to form with solution conduit raised seals ring and is not easy to extract and closed state; When solution conduit bottom protrusion and junction, solution conduit bottom are stressed, the bottom cut channel fracture of its periphery, cracking was in opened condition after connecting pipe bottom cut channel sheet was subjected to pressing force;

Step 4, press the lid of solution conduit, make periphery raised seals ring and inner second groove fit of solution conduit of its lid, solution in the solution conduit is extruded the slit of partly being ruptured by the solution conduit bottom protrusion and flows downward, through in opened condition connecting pipe bottom cut channel sheet water conservancy diversion to following test paper, the sample solution of solution conduit flows to be finished correlated response and demonstrates signals such as color/fluorescent light on the test strips, so far finish test.

Step 3, above-mentioned solution conduit is inserted in the counterbore shape interface of connecting pipe, the solution conduit bottom protrusion contacts and presses connecting pipe bottom cut channel sheet, the stressed back of cut channel sheet, connecting pipe bottom cracking in opened condition, by the rotation solution conduit, the solution conduit bottom protrusion continues to insert solution conduit from the annular cut channel fracture of connecting pipe bottom, the solution conduit exterior groove is cooperated with solution conduit raised seals ring form overhead structure, this solution conduit will oppositely be withstood to be and can not extract and sealing state by this overhead structure;

Step 4 is installed another solution conduit as

step

2,3 in another counterbore shape interface of connecting pipe;

Step 5, press the lid of two solution conduit respectively, make periphery raised seals ring and inner second groove fit of solution conduit of its lid, the slit that solution in the solution conduit is extruded by the fracture of solution conduit bottom protrusion flows downward, through in opened condition connecting pipe bottom cut channel sheet water conservancy diversion to following test paper, finally flow to test strips respectively two positions from the sample solution of two solution conduit and finish correlated response and demonstrate signal such as color/fluorescent light, so far finish test.

In another aspect of this invention, also provide a kind of using method of described enclosed chromatographic test paper pick-up unit, it is characterized in that, comprise the steps:

Step 1, test paper are installed in the test paper pipe, and test paper pipe projection draw-in groove blocks test paper, and the related test paper of test paper pipe injects in the interface of connecting pipe and its coupling, and test paper pipe exterior groove cooperates fixing with test paper pipe raised seals ring, and sealing can not be extracted;

Step 2 is put into test solution in the solution conduit body, and the solution conduit lid is covered in the solution conduit body, and inner first groove fit of solution conduit lid periphery raised seals ring and solution conduit forms first solution conduit;

Step 3 is built the lid that is placed with another solution conduit of test solution, and inner first groove fit of solution conduit lid periphery raised seals ring and solution conduit forms second solution conduit;

Step 4, second solution conduit is inserted in the counterbore shape cavity of top of closure of first solution conduit, the bottom protrusion of second solution conduit is pushed the cut channel sheet of the first solution conduit cover bottom, the fracture of cut channel sheet in opened condition, the second solution conduit bottom protrusion is inserted and is entrenched in the pit of the first solution conduit cover bottom, rotates second solution conduit, and the second solution conduit bottom protrusion is from its bottom cut channel fracture, liquid in second solution conduit, flow out in the slit of from then on rupturing; Continue to insert second solution conduit, the solution conduit exterior groove of second solution conduit cooperates fixing with the solution conduit lid internal protrusion sealing ring of first solution conduit, and sealing can not be extracted;

Step 5, press the lid of second solution conduit, make periphery raised seals ring and inner second groove fit of second solution conduit of its lid, solution is extruded by the crack of second solution conduit bottom via in opened condition the first solution conduit lid cut channel sheet in the solution conduit, flow in following first solution conduit, two kinds of test solutions are mixed into one;

Step 6, repeating

step

3,4,5 can be mixed into one with more solution;

Step 7, above-mentioned first solution conduit that surpasses a solution conduit sample solution that is equipped with is installed in the counterbore shape interface of connecting pipe, the solution conduit bottom protrusion contacts and presses connecting pipe bottom cut channel sheet, the stressed back of cut channel sheet, connecting pipe bottom cracking in opened condition, by the rotation solution conduit, the solution conduit bottom protrusion is from the annular cut channel fracture of connecting pipe bottom, continue to insert solution conduit, the solution conduit exterior groove is cooperated with solution conduit raised seals ring form overhead structure, this solution conduit will oppositely be withstood to be and can not extract and sealing state by this overhead structure;

Step 8, press second solution conduit, make lid periphery raised seals ring and inner second groove fit of first solution conduit of first solution conduit, the slit that mixed solution is extruded by the fracture of solution conduit bottom protrusion flows downward, through in opened condition connecting pipe bottom cut channel sheet water conservancy diversion to following test paper, final biased sample solution is finished correlated response and is demonstrated signal such as color/fluorescent light in test strips, so far finishes test.

Compared with prior art, beneficial effect of the present invention is:

1. good airproof performance: special sealing ring and the coupling design of groove have good leakproofness between each assembly, ensure the sample solution device of can not escaping out, contaminated environment.

2. belong to disposable operative installations: all be to connect by reverse overhead structure between each parts, after therefore in a single day cooperation puts in place, unless be subjected to strong physical action external force, this device will be kept reverse barb and sealing characteristics.

3. simple in structure, volume is small and exquisite: apparatus structure is only by the parts (solution conduit of three kinds of small sizes, connecting pipe and test paper pipe) form, between each parts by jack (connecting pipe interface, raised seals ring and groove fit buckle) couple together, can seal stack between sleeve pipe (solution conduit), array mode is various, is beneficial to application.

4. realized the detection of multiple sample solution: can detect the plurality of target material simultaneously as required in connecting pipe two solution conduit of assembling and a plurality of solution conduit stack assembling.

5. material is simple and safe: the material of device is plastics, does not comprise the metal blade member.

6. install simple, easy to operate: apparatus of the present invention are installed simple, use this device for detection of method step simple, easy to operate.

Description of drawings

Fig. 1 is the assembling synoptic diagram of the embodiment of the invention 1 enclosed chromatographic test paper pick-up unit;

Fig. 2 is the structural representation (under solution conduit lid open mode) of the solution conduit of the embodiment of the invention 1;

Fig. 3 is the solution conduit body cut-open view of the embodiment of the invention 1;

Fig. 4 is the solution conduit lid cut-open view of the embodiment of the invention 2;

Fig. 5 is the structural representation of the connecting pipe of the embodiment of the invention 1;

Fig. 6 is the connecting pipe cut-open view of the embodiment of the invention 1;

Fig. 7 is the structural representation of the test paper pipe of the embodiment of the invention 1;

Fig. 8 is the commentaries on classics figure cut-open view of the embodiment of the invention 1;

Fig. 9 is the folded cut-open view of using of the solution conduit of the embodiment of the invention 2;

Figure 10 is the anti-cooperation partial sectional view of extracting of several places sealing among Fig. 8 of the present invention and Fig. 9;

Figure 11 is the solution conduit body cut-open view of the embodiment of the invention 3;

Figure 12 is the structural representation of the connecting pipe of the embodiment of the invention 3;

Figure 13 is the assembling synoptic diagram of the embodiment of the invention 3;

Figure 14 is the structural representation of the test paper pipe of the embodiment of the invention 4.

Description of reference numerals is as follows among the figure:

1, solution conduit, 11, the solution conduit body, 12, the solution conduit lid, 111, solution conduit bottom protrusion, 112, the solution conduit exterior groove, 113A, inner first groove of solution conduit, 113B, inner second groove of solution conduit, 114, solution conduit bottom cut channel, 121, solution conduit lid periphery raised seals ring, 122, solution conduit lid internal protrusion sealing ring, 123, solution conduit lid cut channel sheet, 124, pit, 125, counterbore shape cavity, 13, the solution conduit connection strap.

2, connecting pipe, 21, solution conduit raised seals ring, 22, test paper pipe raised seals ring, 23, the connecting pipe slope, 24, connecting pipe bottom cut channel sheet, 25, pit, 25A, bossing, 25B, solution channel hole, 26, counterbore shape interface, 27, interface.

3, test paper pipe, 31, test paper pipe exterior groove, 32, test paper pipe projection swash plate, 33, test paper pipe projection draw-in groove, when being installed, blocks by test paper the effect of test paper, 34, annular groove.

4, test paper.

21-112 represents connecting pipe upper lobes 21 and solution conduit exterior groove 112 cooperation places; In like manner 121-113B, 22-31,112-122 are the two cooperation place.

Embodiment

Be described in detail of the present invention below in conjunction with drawings and Examples.

Embodiment 1

As shown in Figure 1, the present invention includes the device that carries out detection reaction on the effluent chromatographic test paper of a kind of guiding liquid flow that is become by a plurality of assembled in the confined space.Three assemblies are respectively the salable reaction solution pipes of superposing type (hereinafter to be referred as solution conduit 1), salable connecting pipe (hereinafter to be referred as connecting pipe 2), salable test paper pipe (hereinafter to be referred as test paper pipe 3).Solution conduit 1 can be one or more, and in the embodiment shown in fig. 1, solution conduit 1 adopts 2.

As shown in Figure 2, solution conduit 1 comprises solution conduit body 11 and solution conduit lid 12, connects by solution conduit connection strap 13 between solution conduit body 11 and the solution conduit lid 12; Solution conduit body 11 comprises solution conduit bottom protrusion 111 from bottom to up, solution conduit exterior groove 112, solution conduit internal recess 113; Solution conduit body 11 is divided into bottom, bottom and top, and solution conduit body 11 upper part diameter are greater than the diameter of solution conduit body 11 bottoms; Solution conduit body 11 bottoms are provided with the solution conduit polycrystalline substance, in the present embodiment, this solution conduit polycrystalline substance is made as solution conduit bottom protrusion 111, the periphery of solution conduit bottom protrusion 111 is provided with solution conduit bottom cut channel 114, when this solution conduit bottom protrusion 111 is subjected to certain acting force, it breaks away from from 114 fractures of bottom cut channel, and the sample solution that is divided in advance this moment in the solution conduit 1 can flow out from the fracture slit; Solution conduit body 11 lower, outer perimeter are provided with solution conduit exterior groove 112, and solution conduit body 11 upper inside wall circumference are provided with solution conduit internal recess 113; The periphery of solution conduit lid 12 is provided with solution conduit lid periphery raised seals ring 121 near bottom position.

As shown in Figure 3, solution conduit body 11 upper inside wall circumference are provided with two grooves up and down, be respectively the inner first groove 113A of solution conduit, the inner second groove 113B of solution conduit, the periphery of described solution conduit lid 12 is provided with raised seals ring 121, this solution conduit lid periphery raised seals ring 121 and inner first groove 113 of solution conduit, the inner second groove 113B of solution conduit can both fitted seal (for example, see 121-113B among Fig. 8, solution conduit lid periphery raised seals ring 121 cooperates fixing with solution conduit internal recess 113B), solution conduit lid 12 solution conduit lid periphery raised seals ring 121 in the process of covering cooperates with the inner first groove 113A of solution conduit earlier, press for the second time back solution conduit lid 12 and can also press LAP again and cooperate with the solution conduit inside second groove 113B, finally the state of covering is and can not extracts and sealing state (internal liquid leakage phenomenon can not take place).The inner first groove 113A of solution conduit can allow solution conduit lid 12 to repeat to open, and the inner second groove 113B of solution conduit then reverse barb lives solution conduit lid 12, makes it form enclosed environment in the disposable back, position that is pressed into, and can not be opened again.

As shown in Figure 3, solution conduit body 11 bottoms are provided with solution conduit bottom protrusion 111, solution conduit bottom protrusion 111 is provided with solution conduit bottom cut channel 114 with solution conduit body 11 junctions, when solution conduit is rotated, this solution conduit bottom protrusion 111 will be obstructed and can not be rotated and break away from from 114 fractures of solution conduit bottom cut channel, and the sample solution that is divided in advance this moment in the solution conduit 1 can flow out from the fracture slit.Described solution conduit bottom cut channel 114 is band wire or a point-like, and the plastic material thickness at cut channel position lacks 0.05-0.5mm than the thickness at other positions; When solution conduit rotation and its bottom protrusion 111 when being stuck, the torsion tolerance value at cut channel position is low than other positions, so solution conduit bottom protrusion 111 will rupture from the cut channel position.

As shown in Figure 5 and Figure 6, connecting pipe 2 is provided with among counterbore shape interface 26(Fig. 5 of one or more and solution conduit 1 coupling and Fig. 6 and shows 2 interfaces), be equipped with solution conduit raised seals ring 21(solution conduit raised seals ring 21 in these 2 counterbore shape interfaces 26 and can cooperate the fixing reverse overhead structure that forms with the solution conduit exterior groove 112 of inserting interface, form sealed environment and can not be opened, see 21-112 among Fig. 8); These 2 counterbore shape interface 26 inner bottom parts are provided with the solution releasing structure, and it gives specific function power to the solution conduit polycrystalline substance can be with its fracture disengaging, and solution discharges from solution conduit; Connecting pipe solution releasing structure bottom is provided with solution channel, and the liquid that solution conduit discharges will flow to the sample solution reception area of the chromatographic test paper in the test paper pipe through solution channel.In the present embodiment, described connecting pipe bottom solution releasing structure is made as for solution conduit bottom protrusion 111 and inserts and chimeric pit 25, and this pit 25 can interact with solution conduit bottom protrusion 111, and the solution of solution conduit is discharged; Described solution channel adopts bottom cut channel sheet 24, and it cuts off connecting pipe counterbore shape interface 26 with test paper interface tube 27 be two separate space; When bottom cut channel sheet 24 was subjected to roof pressure, it began to rupture slit formation solution channel from the position that cut channel is arranged, and the liquid that discharges when solution conduit will be through flowing to the sample solution reception area of the chromatographic test paper in the test paper pipe herein; This pit 25 is chimeric with the shape of solution conduit bottom protrusion 111, it can be the chimeric shape of in-line or cruciform or other and solution conduit bottom protrusion 111, when solution conduit is carried out the rotation of certain angle, solution conduit bottom protrusion 111 will be blocked by chimeric pit 25 and can not be rotated, thereby discharges liquid after cut channel 114 fractures of solution conduit bottom; When solution conduit bottom protrusion 111 continued to insert, connecting pipe bottom cut channel sheet 24 had the position complete rupture of cut channel; The plastic material thickness at the cut channel position of connecting pipe bottom cut channel sheet 24 lacks 0.05-0.2mm than the thickness at other positions, the circle that this connecting pipe bottom cut channel sheet 24 is band wire or point-like cut channel or square plate are when the solution conduit bottom protrusion 111 of inserting the connecting pipe bottom is pressed connecting pipe bottom cut channel sheet 24, the tension force tolerance value at cut channel position is low than other positions, so connecting pipe bottom cut channel sheet 24 begins fracture from certain position of cut channel; When solution conduit bottom protrusion 111 continued to insert, connecting pipe bottom cut channel sheet 24 had the position complete rupture of cut channel.If the solution conduit of inserting from top bottom is twisted into two parts, its inner liquid will flow into connecting pipe 2 inside from cut channel sheet 24 gaps of these connecting pipe 2 bottom breaks.Also be provided with an interface 27 that mates with test paper pipe 3 on the connecting pipe 2, being provided with test paper pipe raised seals ring 22(test paper pipe raised seals ring 22 in this interface 27 cooperates fixing with test paper pipe exterior groove 31, form reverse overhead structure, making the test paper pipe that is inserted into connecting pipe after stressed go into the back, position forms sealed environment and can not be opened, see 22-31 among Fig. 8), in connecting pipe 2 inside, be positioned at the interface 27 of test paper pipe 3 couplings and the connecting portion of the counterbore shape interface 26 that solution conduit 1 is mated and be provided with a connecting pipe slope 23, when test paper pipe 3 inserts connecting pipe 2, this test paper pipe projection swash plate 32 will be arrived connecting pipe slope 23 with top behind the test paper 4 picking-up certain altitudes by the top certain angle.

As shown in Figure 7, test paper pipe 3 is hollow elongated tubular of an end opening, and its openend two sides are provided with test paper pipe projection draw-in groove 33, plays when test paper 4 is installed and blocks and the fixedly effect of test paper 4, and test paper pipe 3 openend bottom surfaces are provided with test paper pipe projection swash plate 32(and see Fig. 8).Also be provided with test paper pipe exterior groove 31 on the test paper pipe 3 coupling positions of inserting connecting pipe 2, test paper pipe exterior groove 31 cooperates fixedly (see figure 8) with test paper pipe raised seals ring 22.Test paper 4 is inserted by test paper pipe 3 opening parts, after inserting fully, pressing test paper 4 at test paper pipe 3 opening parts is stuck between the test paper pipe projection draw-in groove 33, can not come off or rock, test paper pipe 3 related test paper 4 insert the interface 27 of connecting pipe 2 and its coupling, the test paper pipe of test paper pipe 3 projection swash plate 32 is subjected to the extruding of connecting pipe 2 will be by the jack-up certain angle, will test paper 4 hold up certain altitudes after the top to connecting pipe slope 23, make test paper 4 surperficial pressurizeds and control liquid sample flow speed (see figure 9).Test paper pipe exterior groove 31 cooperates fixing (seeing 22-31 among Fig. 8) with test paper pipe raised seals ring 22, and sealing can not be extracted (internal liquid leakage phenomenon can not take place).

Figure 10 is that several places sealing among Fig. 8 and Fig. 9 is prevented extracting the cooperation partial sectional view, and shown in Fig. 8,9,10, solution conduit raised seals ring 21 and solution conduit exterior groove 112 cooperate buckles; Solution conduit lid periphery raised seals ring 121 cooperates buckle with the inner second groove 113B of solution conduit, test paper pipe raised seals ring 22 cooperates buckle with test paper pipe exterior groove 31, solution conduit lid internal protrusion sealing ring 122 cooperates buckle with solution conduit exterior groove 112, these several places cooperate projection and the groove fit at buckle place not to be drawn out easily, protruding and following arc convex can seal, and makes internal liquid leakage phenomenon can not take place.The inner first groove 113A of solution conduit, the inner second groove 113B of solution conduit, solution conduit exterior groove 112 and test paper pipe exterior groove 31 are annular groove.

This embodiment as shown in Figure 8, is example with solution conduit 12 of employings in use, and the using method of apparatus of the present invention comprises the steps:

1, at first, test paper 4 is installed in (being about to test paper 4 is inserted by test paper pipe 3 opening parts in the test paper pipe 3, after inserting fully, pressing test paper 4 at test paper pipe 3 opening parts is stuck between the test paper pipe projection draw-in groove 33, can not come off or rock), an end that then test paper pipe 3 is had test paper 4 injects in the interface of connecting pipe 2 and test paper pipe 3 couplings, and the extruding that the protruding swash plate 32 of the test paper pipe of test paper pipe 3 is subjected to connecting pipe 2 interface inner structures is upspring and can not be ruptured.Test paper 4 is pushed on the connecting pipe slope 23 of test paper pipe projection swash plate 32 in connecting pipe 2 interfaces of upspringing, test paper 4 distortion are one section shape that arches upward, the test solution that stays is stoped within the specific limits, test paper pipe exterior groove 31 cooperates fixing (seeing 22-31 among Fig. 8) with test paper pipe raised seals ring 22, and sealing can not be extracted (internal liquid leakage phenomenon can not take place).

2, the lid that will be placed with the solution conduit of test solution is built (namely put into test solution in solution conduit body 11, and solution conduit lid 12 lids are gone in the solution conduit body 11), and solution conduit lid periphery raised seals ring 121 cooperates with the inner first groove 113A of solution conduit.

3, above-mentioned solution conduit 1 is installed on the connecting pipe 2 (being about to solution conduit 1 inserts in the connecting pipe 2 in the counterbore shape interface 26 with its coupling), solution conduit bottom protrusion 111 contacts and extruded joint pipe bottom cut channel sheet 24, connecting pipe bottom cut channel sheet 24 stressed back crackings in opened condition, connecting pipe bottom cut channel sheet 24 ruptures since an end under the pressure of solution conduit bottom protrusion 111, finally be downward bending, by rotation solution conduit 1, (solution conduit bottom protrusion 111 is provided with solution conduit bottom cut channel 114 with solution conduit body 11 junctions to solution conduit bottom protrusion 111 breaking releasings, when rotation solution conduit 1, rupture fully in cut channel 114 places, solution conduit bottom, solution conduit bottom protrusion 111 comes off from solution conduit bottom cut channel 114), after continuing to insert solution conduit 1 fully, its solution conduit exterior groove 112 is cooperated with solution conduit raised seals ring 21 form overhead structure, this solution conduit 1 will by the overhead structure in the interface oppositely withstand be can not extract and sealing state (leakage phenomenon can not take place in internal liquid, under ordinary people's one-handed performance situation, can not be reversed and extract, even both hands oppositely also need relative effort just may extract (see figure 8) out.

4, as

step

2,3 another solution conduit is installed in another counterbore shape interface 26 of connecting pipe.

5, press the lid of two solution conduit respectively, the inner second groove 113B of solution conduit lid periphery raised seals ring 121 and solution conduit is cooperated, the slit that solution in the solution conduit is extruded by 111 fractures of solution conduit bottom protrusion flows downward, through connecting pipe bottom cut channel sheet 24 in opened condition, water conservancy diversion is to following test paper 4, finally flow to test strips respectively two positions from the sample solution of two solution conduit and finish correlated response and demonstrate signal such as color/fluorescent light, so far finish test.

In addition, adopting a solution conduit with apparatus of the present invention is example, and its using method comprises the steps:

Step 1, test paper 4 inserts and is installed in the test paper pipe 3, test paper pipe projection draw-in groove 33 blocks test paper 4, and test paper pipe 3 related test paper 4 inject in the interface 27 of connecting pipe and its coupling, and test paper pipe exterior groove 31 cooperates the reverse barb sealing in back to extract with test paper pipe raised seals ring 22;

Step 2 is put into sample solution in solution conduit body 11, and solution conduit lid 12 lids are gone in the solution conduit body 11, and solution conduit lid periphery raised seals ring 121 cooperates with the inner first groove 113A of solution conduit;

Step 3, above-mentioned solution conduit is inserted in the counterbore shape interface 26 of connecting pipe, solution conduit bottom protrusion 111 contacts and presses connecting pipe bottom cut channel sheet 24, cut channel sheet 24 stressed back crackings in opened condition, by the rotation solution conduit, solution conduit bottom protrusion 111 is from the annular cut channel fracture of connecting pipe bottom, continue to insert solution conduit, solution conduit exterior groove 112 is cooperated with solution conduit raised seals ring 21 form overhead structure, this solution conduit will oppositely be withstood to be and can not extract and sealing state by this overhead structure;

Step 5, press the lid of solution conduit, the periphery raised seals ring 121 of its lid is cooperated with the inner second groove 113B of solution conduit, the slit that solution in the solution conduit is extruded by 111 fractures of solution conduit bottom protrusion flows downward, through cut channel sheet 24 water conservancy diversion of in opened condition connecting pipe inside to following test paper, the sample solution of solution conduit flows to be finished correlated response and demonstrates signals such as color/fluorescent light on the test strips, so far finish test.

Embodiment 2

When after two kinds of test solution hybrid reactions of needs, testing, need two solution conduit stacks, apparatus of the present invention can adopt another structure, as shown in Figure 4, a counterbore shape cavity 125 can be established in solution conduit lid 12 tops, can insert another solution conduit (see figure 9) in this counterbore shape cavity 125; Counterbore shape cavity 125 bottoms of solution conduit lid 12 are provided with solution conduit lid cut channel sheet 123 and insert and chimeric pit 124 for solution conduit bottom protrusion 111.Solution conduit bottom protrusion 111 and pit 124 are the mutual embedded structure of in-line or cruciform or other shapes; The periphery of solution conduit lid 12 is provided with solution conduit lid periphery raised seals ring 121 near the cover bottom position, the inwall of solution conduit lid 12 is provided with in solution conduit lid internal protrusion sealing ring 122(solution conduit lid internal protrusion sealing ring 122 and the insertion lid counterbore shape cavity 125 and solution conduit lid cut channel sheet 123 is backed down the solution conduit exterior groove 112 that is another solution conduit of opening shape near the cap top position and cooperates fixing, form reverse overhead structure, form sealed environment and can not be opened see 112-122 among Fig. 9).Solution conduit lid cut channel sheet 123 cut channel position plastic material thickness lack 0.05-0.2mm than the thickness at other positions, and this cut channel can be the plastic sheet of a notched annular wire or point-like cut channel, and the thickness of the barbed portion of annular does not change; When the solution conduit bottom protrusion 111 of inserting the connecting pipe bottom was pressed cut channel sheet 123, the tension force tolerance value at cut channel position was low than other positions, so cut channel sheet 123 begins fracture from certain position of cut channel; When solution conduit bottom protrusion 111 continued to insert, cut channel sheet 123 had the position complete rupture of cut channel, and the cut channel barbed portion that thickness does not have to change can not rupture.

As shown in Figure 9, when after two kinds of test solution hybrid reactions of needs, testing, the second solution conduit 1B can be inserted by the bottom in the counterbore shape cavity 125 of lid 12 of the first solution conduit 1A (as Fig. 9), the first solution conduit 1A lid cut channel sheet 123 begins fracture by the cut channel bosom under bottom protrusion 111 base pressures of the second solution conduit 1B, finally be the open mode (see figure 9) that does not rupture in no cut channel place, the second solution conduit 1B bottom protrusion, 111 both sides are dropped between the pit 124 of the first solution conduit 1A, the second solution conduit 1B above the rotation, the second solution conduit 1B bottom protrusion 111 is subjected to the stopping of pit 124 of the first solution conduit 1A, cut channel 114 fractures of second solution conduit 1B bottom, the second solution conduit 1B bottom protrusion 111 breaks away from the first solution conduit 1A, continue to insert the second solution conduit 1B, the solution conduit exterior groove 112 of the second solution conduit 1B cooperates fixing with the solution conduit lid internal protrusion sealing ring 122 of the first solution conduit 1A, and sealing can not be extracted, the drop space appears in the bottom of the second solution conduit 1B bottom protrusion 111 and the second solution conduit 1B, and test solution flows in the first solution conduit 1A by space and the first solution conduit 1A lid cut channel sheet 123 in opened condition.

This embodiment needs two solution conduit stacks in use, and namely the second solution conduit 1B is inserted (see figure 9) in the cavity of top of closure of the first solution conduit 1A by the bottom.As shown in Figure 9, the using method of apparatus of the present invention comprises the steps:

2, the lid that will be placed with the solution conduit of test solution is built and (is namely put into test solution in solution conduit body 11, and it is interior that solution conduit lid 12 is covered solution conduit body 11), solution conduit lid periphery raised seals ring 121 cooperates with the inner first groove 113A of solution conduit, forms the first solution conduit 1A.

3, the lid that will be placed with another solution conduit of test solution is built, and solution conduit lid periphery raised seals ring 121 cooperates with the inner first groove 113A of solution conduit, forms the second solution conduit 1B.

4, the second solution conduit 1B is inserted by the bottom in the counterbore shape cavity 25 of top of closure of the first solution conduit 1A, the cut channel sheet 123 of the second solution conduit 1B bottom protrusion, 111 extruding, the first solution conduit 1A cover bottom, cut channel sheet 123 begins fracture by the cut channel place under solution conduit bottom protrusion 111 base pressures of the second solution conduit 1B, finally be the open mode that does not rupture in no cut channel place, the second solution conduit 1B bottom protrusion 111 is inserted and is entrenched in the pit 124 of the first solution conduit 1A cover bottom, rotate the second solution conduit 1B, the second solution conduit 1B bottom protrusion 111 is from cut channel 114 fractures of second solution conduit 1B bottom, the second solution conduit 1B bottom protrusion 111 breaks away from the second solution conduit 1B, liquid in the second solution conduit 1B, flow out in the slit of from then on rupturing.Continue to insert the second solution conduit 1B, the solution conduit exterior groove 112 of the second solution conduit 1B cooperates fixing with the solution conduit lid internal protrusion sealing ring 122 of the first solution conduit 1A, and sealing can not be extracted.

5, press the lid of the second solution conduit 1B, the periphery raised seals ring 121 of its lid is cooperated with the inner second groove 113B of the second solution conduit 1B, solution is extruded by the crack of second solution conduit (1B) bottom via in opened condition the first solution conduit 1A lid cut channel sheet 123 in the solution conduit, flow in the following first solution conduit 1A, two kinds of test solutions are mixed into one;

6, repeating

step

3,4,5, more solution can be mixed into one;

7, the above-mentioned first solution conduit 1A that is equipped with above a solution conduit sample solution is installed in the counterbore shape interface 26 of connecting pipe 2 and its coupling, solution conduit bottom protrusion 111 contacts and extruded joint pipe bottom cut channel sheet 24, connecting pipe bottom cut channel sheet 24 stressed back crackings in opened condition, connecting pipe bottom cut channel sheet 24 ruptures since an end under the pressure of solution conduit bottom protrusion 111, finally be downward bending, by rotating the first solution conduit 1A, (solution conduit bottom protrusion 111 is provided with solution conduit bottom cut channel 114 with solution conduit body 11 junctions to solution conduit bottom protrusion 111 breaking releasings, when rotation solution conduit 1, rupture fully in cut channel 114 places, solution conduit bottom, solution conduit bottom protrusion 111 comes off from solution conduit bottom cut channel 114), after continuing to insert the first solution conduit 1A fully, its solution conduit exterior groove 112 is cooperated with solution conduit raised seals ring 21 form overhead structure, this first solution conduit 1A will by the overhead structure in the interface oppositely withstand be can not extract and sealing state (leakage phenomenon can not take place in internal liquid, under ordinary people's one-handed performance situation, can not be reversed and extract, even both hands oppositely also need relative effort just may extract (see figure 8) out.

8, press the second solution conduit 1B, the lid periphery raised seals ring 121 of the first solution conduit 1A is cooperated with the inner second groove 113B of the first solution conduit 1A, the slit that mixed solution is extruded by 111 fractures of solution conduit bottom protrusion flows downward, through cut channel sheet 24 water conservancy diversion of in opened condition connecting pipe inside to following test paper 4, final biased sample solution is finished correlated response and is demonstrated signal such as color/fluorescent light in test strips, so far finishes test.

Embodiment 3

Shown in Figure 11-13, this embodiment 3 is with the difference of embodiment 1: the solution conduit polycrystalline substance is provided with bottom cut channel 114, but does not establish bottom protrusion; Connecting pipe bottom solution releasing structure by bossing 25A and on every side set solution channel hole 25B form; Bossing 25A replaces the solution conduit polycrystalline substance, when the solution conduit polycrystalline substance is subjected to acting force that bossing 25A replaces, it breaks away from from 114 fractures of bottom cut channel, the sample solution that is divided in advance this moment in the solution conduit 1 can flow out from the fracture slit, and flows to the sample solution reception area of the chromatographic test paper in the test paper pipe by the solution channel hole 25B of connecting pipe bottom; Described solution conduit bottom cut channel 114 is wire or point-like, and the material thickness at cut channel position lacks 0.05-0.5mm than the thickness at other positions; When the solution conduit polycrystalline substance was subjected to specific function power, the mechanics tolerance value at cut channel position was low than other positions, therefore will be from the cut channel position fracture of solution conduit bottom cut channel 114.Other structures of present embodiment are identical with embodiment 1.

Embodiment 4

As shown in figure 14, embodiment 4 is with the difference of embodiment 1-3: test paper pipe 3 distal portion are provided with annular groove 34, when firmly acquiring a certain degree, can be convenient to that test sample is carried out abatement of pollution and handle from the annular groove 34 test paper pipe 3 that fractures.The (see figure 4) of simultaneously cut channel sheet 123 roof pressures of counterbore shape cavity 125 bottoms of solution conduit lid 12 being broken, then all components is immersed in the nanometer titanium dioxide titanium solution, then the objectionable impurities in the sample solution in the irradiation decline deblocking enclosed chromatographic test paper device of ultraviolet light.

Claims

1. an enclosed chromatographic test paper pick-up unit is characterized in that, comprises solution conduit (1), connecting pipe (2) and test paper pipe (3);

Described solution conduit (1) comprises solution conduit body (11) and solution conduit lid (12); Described solution conduit body (11) inwall periphery is provided with two grooves up and down, is respectively inner first groove (113A) of solution conduit, inner second groove (113B) of solution conduit; The periphery of described solution conduit lid (12) is provided with raised seals ring (121), inner first groove (113A) of this solution conduit lid periphery raised seals ring (121) and solution conduit, inner second groove of solution conduit (113B) can both fitted seal, inner first groove of solution conduit (113A) can allow solution conduit lid (12) to repeat to open, inner second groove of solution conduit (113B) then reverse barb is lived solution conduit lid (12), make it form enclosed environment in the disposable back, position that is pressed into, be not easy to be opened again; Described solution conduit body (11) periphery is provided with solution conduit exterior groove (112), can cooperate with the raised seals ring (21) established in connecting pipe (2) corresponding interface to form reverse overhead structure, forms enclosed environment and is not easy to be opened; Described solution conduit body (11) bottom is provided with polycrystalline substance, bottom cut channel (114) is established in its neighboring, when polycrystalline substance was subjected to certain acting force, it broke away from from bottom cut channel (114) fracture, and the sample solution that is divided in advance this moment in the solution conduit (1) can flow out from the fracture slit;

Described test paper pipe (3) is the hollow elongated tubular of an end opening, test paper pipe (3) is provided with test paper pipe exterior groove (31) at the interface position of inserting connecting pipe (2), this exterior groove (31) cooperates oppositely barb formation enclosed environment of back with the test paper pipe raised seals ring (22) that connecting pipe (2) inwall is established, be not easy to be opened again;

Described connecting pipe (2) is provided with the counterbore shape interface (26) of one or more and described solution conduit (1) lower tube body profile coupling; Be provided with solution conduit raised seals ring (21) in the described counterbore shape interface (26), can cooperate with the solution conduit exterior groove (112) of inserting interface to form reverse overhead structure, formation enclosed environment and be not easy to be opened again; Also be provided with interface (27) one or more and test paper pipe (3) coupling on this connecting pipe (2), be provided with test paper pipe raised seals ring (22) in this interface (27), this test paper pipe raised seals ring (22) fits in reverse barb hermetically-sealed construction with the test paper pipe exterior groove (31) of inserting interface (27) and is not easy to be opened; Connecting pipe counterbore shape interface (26) bottom is provided with the solution releasing structure, and it gives specific function power to the solution conduit polycrystalline substance can be with its fracture disengaging, and solution discharges from solution conduit; Connecting pipe solution releasing structure bottom is provided with solution channel, and the liquid that solution conduit discharges will flow to the sample solution reception area of the chromatographic test paper in the test paper pipe through solution channel.

2. device as claimed in claim 1, it is characterized in that described test paper pipe (3) distal portion is provided with annular groove (34), when firmly acquiring a certain degree, can be convenient to that test sample is carried out abatement of pollution and handle from annular groove (34) the test paper pipe (3) that fractures; Described test paper pipe (3) openend is provided with test paper pipe projection draw-in groove (33), blocks when being used for test paper is installed and fixing test paper; Test paper pipe (3) openend bottom surface is provided with test paper pipe projection swash plate (32); Connecting portion inner at connecting pipe (2), that be positioned at test paper pipe matched interfaces (27) and solution conduit coupling counterbore shape interface (26) is provided with connecting pipe slope (23), when the test paper pipe inserts connecting pipe, this test paper pipe projection swash plate (32) will be by the top certain angle, and test paper is held up behind the certain altitude near connecting pipe slope (23).

3. device as claimed in claim 1, it is characterized in that, described solution conduit polycrystalline substance is made as bottom protrusion (111), the periphery of this bottom protrusion (111) is provided with solution conduit bottom cut channel (114), when this bottom protrusion (111) when being subjected to certain acting force, it breaks away from from bottom cut channel (114) fracture, and the sample solution that is divided in advance this moment in the solution conduit (1) can flow out from the fracture slit;

Described connecting pipe bottom solution releasing structure is made as for solution conduit bottom protrusion (111) and inserts and chimeric pit (25), and this pit (25) can interact with solution conduit bottom protrusion (111), and the solution of solution conduit is discharged; Described solution channel adopts bottom cut channel sheet (24), and it cuts off connecting pipe counterbore shape interface (26) with test paper interface tube (27) be two separate space; When bottom cut channel sheet (24) when being subjected to roof pressure, its slit that begins from the position that cut channel is arranged to rupture forms solution channel, and the liquid that discharges when solution conduit will be through flowing to the sample solution reception area of the chromatographic test paper in the test paper pipe herein.

4. device as claimed in claim 3, it is characterized in that, described connecting pipe bottom cut channel sheet (24) is circle or the square plate of band wire or point-like cut channel, and the cut channel position material thickness of this bottom cut channel sheet (24) lacks 0.05-0.5mm than the thickness at other positions; When this bottom cut channel sheet (24) when being subjected to pressing, the mechanics tolerance value at cut channel position is low and begin fracture from certain position of cut channel than other positions; When for a long time stressed, bottom cut channel sheet (24) has the position complete rupture of cut channel;

Described solution conduit bottom cut channel (114) is wire or point-like, and the material thickness at cut channel position lacks 0.05-0.5mm than the thickness at other positions; When solution conduit bottom protrusion (111) was subjected to specific function power, the mechanics tolerance value at cut channel position was low than other positions, so bottom protrusion (111) will rupture from the cut channel position with junction, solution conduit bottom;

Described solution conduit bottom protrusion (111) pit (25) bottom described connecting pipe is the mutual embedded structure of in-line or cruciform or other shapes; Inner first groove (113A) of described solution conduit, inner second groove (113B) of solution conduit, solution conduit exterior groove (112) and test paper pipe exterior groove (31) are annular groove.

5. as claim 1 or 3 described devices, it is characterized in that described solution conduit lid (12) top is provided with a counterbore shape cavity (125), in this counterbore shape cavity (125), can insert another solution conduit lower tube body and form the stack sleeve structure; Described counterbore shape cavity (125) bottom is provided with the solution releasing structure, and solution releasing structure bottom is provided with solution channel; The internal face of solution conduit lid counterbore shape cavity (125) is provided with raised seals ring (122), this raised seals ring (122) cooperates the back to form reverse barb enclosed construction with the exterior groove (112) of another solution conduit of inserting lid counterbore shape cavity (125), is not easy to be opened again.

6. device as claimed in claim 5, it is characterized in that, described solution conduit polycrystalline substance is bottom protrusion (111), the solution releasing structure of the counterbore shape cavity (125) of described solution conduit lid is for inserting and chimeric pit (124) for solution conduit bottom protrusion (111), and the bottom pit (124) of the counterbore shape cavity (125) of described solution conduit bottom protrusion (111) and described solution conduit lid is the mutual embedded structure of in-line or cruciform or other shapes; Described solution channel adopts bottom cut channel sheet (123), and when bottom cut channel sheet (123) when being subjected to roof pressure, its slit that begins from the position that cut channel is arranged to rupture forms solution channel; This bottom cut channel sheet (123) is circle or the square plate of band wire or point-like cut channel, and cut channel position material thickness lacks 0.05-0.5mm than the thickness at other positions; When this bottom cut channel sheet (123) when being subjected to pressing, the mechanics tolerance value at cut channel position is low and begin fracture from certain position of cut channel than other positions; When for a long time stressed, this bottom cut channel sheet (123) has the position complete rupture of cut channel.

7. device as claimed in claim 1 is characterized in that, described solution conduit polycrystalline substance is provided with bottom cut channel (114); Connecting pipe bottom solution releasing structure by bossing (25A) and on every side set solution channel hole (25B) form; Bossing (25A) is replaced the solution conduit polycrystalline substance, when the solution conduit polycrystalline substance is subjected to acting force that bossing (25A) replaces, it breaks away from from bottom cut channel (114) fracture, the sample solution that is divided in advance this moment in the solution conduit (1) can flow out from the fracture slit, and flows to the sample solution reception area of the chromatographic test paper in the test paper pipe by the solution channel hole (25B) of connecting pipe bottom.

8. a solution conduit is characterized in that, described solution conduit comprises solution conduit body (11) and solution conduit lid (12); Described solution conduit body (11) inwall periphery is provided with two grooves up and down, is respectively inner first groove (113A) of solution conduit, inner second groove (113B) of solution conduit; The periphery of described solution conduit lid (12) is provided with raised seals ring (121), inner first groove (113A) of this raised seals ring (121) and solution conduit, inner second groove of solution conduit (113B) can both fitted seal, inner first groove of solution conduit (113A) can allow solution conduit lid (12) to repeat to open, inner second groove of solution conduit (113B) then reverse barb is lived solution conduit lid (12), make it form enclosed environment in the disposable back, position that is pressed into, be not easy to be opened again.

9. solution conduit as claimed in claim 8; It is characterized in that described solution conduit body (11) periphery is provided with exterior groove (112), can cooperate with the raised seals ring (21) of the round tube inner wall of some coupling design to form reverse overhead structure, formation enclosed environment and be not easy to be opened again; Described solution conduit body (11) bottom is provided with polycrystalline substance, this polycrystalline substance and solution conduit body (11) base plane junction are provided with solution conduit bottom cut channel (114), when polycrystalline substance is subjected to certain acting force, it and junction, solution conduit bottom will break away from from solution conduit bottom cut channel (114) fracture, and the sample solution that is divided in advance this moment in the solution conduit (1) can flow out from the fracture slit; Described solution conduit bottom cut channel (114) is wire or point-like, and the material thickness at cut channel position lacks 0.05-0.5mm than the thickness at other positions; When solution conduit polycrystalline substance and solution conduit junction were stressed, the torsion tolerance value at cut channel position was low than other positions, so polycrystalline substance and solution conduit junction will be from the cut channel position fractures of solution conduit bottom cut channel (114).

10. solution conduit as claimed in claim 8, it is characterized in that, described solution conduit body (11) periphery is provided with exterior groove (112), can cooperate to form reverse overhead structure formation enclosed environment and be not easy to be opened again with the raised seals ring (21) of the round tube inner wall of some coupling design; Described solution conduit lid (12) top is provided with a counterbore shape cavity (125), can insert another solution conduit bottom body in this counterbore shape cavity (125); The internal face of solution conduit lid counterbore shape cavity (125) is provided with raised seals ring (122), this raised seals ring (122) cooperates the back to form reverse barb enclosed construction with the exterior groove (112) of inserting another solution conduit of lid counterbore shape cavity (125), is not easy to be opened again; Described counterbore shape cavity (125) bottom is provided with for the solution conduit polycrystalline substance inserts and chimeric solution releasing structure, and solution releasing structure bottom is provided with solution channel.

11. solution conduit as claimed in claim 10, it is characterized in that, described solution conduit polycrystalline substance is bottom protrusion (111), described solution releasing structure is for inserting and chimeric pit (124) for solution conduit bottom protrusion (111), and described solution conduit bottom protrusion (111) and described pit (124) are the mutual embedded structure of in-line or cruciform or other shapes; Described solution channel adopts bottom cut channel sheet (123), and when bottom cut channel sheet (123) when being subjected to roof pressure, its slit that begins from the position that cut channel is arranged to rupture forms solution channel;

Inner first groove (113A) of described solution conduit, inner second groove (113B) of solution conduit, solution conduit exterior groove (112) are annular groove;

Described cover bottom cut channel sheet (123) is circle or the square plate of band wire or point-like cut channel, and cut channel position material thickness lacks 0.05-0.5mm than the thickness at other positions; When this bottom cut channel sheet (123) when being subjected to pressing, the tension force tolerance value at cut channel position is low than other positions, and therefore this bottom cut channel sheet (123) begins from certain position of cut channel to rupture.

12. the using method of enclosed chromatographic test paper pick-up unit as claimed in claim 3 is characterized in that, comprises the steps:

Step 1, test paper (4) inserts and is installed in the test paper pipe (3), test paper pipe projection draw-in groove (33) blocks test paper (4), the related test paper of test paper pipe (3) (4) injects in the interface (27) of connecting pipe and its coupling, and test paper pipe exterior groove (31) cooperates the reverse barb sealing in back to extract with test paper pipe raised seals ring (22);

Step 2 is put into sample solution in solution conduit body (11), and solution conduit lid (12) lid is gone in the solution conduit body (11), and solution conduit lid periphery raised seals ring (121) cooperates with inner first groove of solution conduit (113A);

Step 3 is inserted above-mentioned solution conduit in the counterbore shape interface (26) of connecting pipe, when solution conduit is inserted into the end, makes solution conduit exterior groove (112) cooperate the formation overhead structure to form with solution conduit raised seals ring (21) and is not easy to extract and closed state; When solution conduit bottom protrusion (111) is stressed with junction, solution conduit bottom, bottom cut channel (114) fracture of its periphery, cracking was in opened condition after connecting pipe bottom cut channel sheet (24) was subjected to pressing force;

Step 4, press the lid of solution conduit, the periphery raised seals ring (121) of its lid is cooperated with inner second groove of solution conduit (113B), the slit that solution in the solution conduit is extruded by solution conduit bottom protrusion part (111) fracture flows downward, through in opened condition connecting pipe bottom cut channel sheet (24) water conservancy diversion to following test paper, the sample solution of solution conduit flows to be finished correlated response and demonstrates signals such as color/fluorescent light on the test strips, so far finish test.

13. the using method of enclosed chromatographic test paper pick-up unit as claimed in claim 3 is characterized in that, comprises the steps:

Step 3, above-mentioned solution conduit is inserted in the counterbore shape interface (26) of connecting pipe, solution conduit bottom protrusion (111) contacts and presses connecting pipe bottom cut channel sheet (24), the stressed back of connecting pipe bottom cut channel sheet (24) cracking in opened condition, by the rotation solution conduit, solution conduit bottom protrusion (111) is from the annular cut channel fracture of connecting pipe bottom, continue to insert solution conduit, solution conduit exterior groove (112) is cooperated with solution conduit raised seals ring (21) form overhead structure, this solution conduit will oppositely be withstood to be and can not extract and sealing state by this overhead structure;

Step 4 is installed another solution conduit as step 2,3 in another counterbore shape interface (26) of connecting pipe;

Step 5, press the lid of two solution conduit respectively, the periphery raised seals ring (121) of its lid is cooperated with inner second groove of solution conduit (113B), the slit that solution in the solution conduit is extruded by solution conduit bottom protrusion (111) fracture flows downward, through in opened condition connecting pipe bottom cut channel sheet (24) water conservancy diversion to following test paper, finally flow to test strips respectively two positions from the sample solution of two solution conduit and finish correlated response and demonstrate signal such as color/fluorescent light, so far finish test.

14. the using method of enclosed chromatographic test paper pick-up unit as claimed in claim 6 is characterized in that, comprises the steps:

Step 1, test paper (4) is installed in the test paper pipe (3), test paper pipe projection draw-in groove (33) blocks test paper (4), the related test paper of test paper pipe (3) (4) injects in the interface (27) of connecting pipe and its coupling, test paper pipe exterior groove (31) cooperates fixing with test paper pipe raised seals ring (22), and sealing can not be extracted;

Step 2, in solution conduit body (11), put into test solution, and solution conduit lid (12) lid gone in the solution conduit body (11), solution conduit lid periphery raised seals ring (121) cooperates with solution conduit inside first groove (113A), forms first solution conduit (1A);

Step 3 is built the lid that is placed with another solution conduit of test solution, and solution conduit lid periphery raised seals ring (121) cooperates with inner first groove of solution conduit (113A), forms second solution conduit (1B);

Step 4, second solution conduit (1B) is inserted in the counterbore shape cavity (125) of top of closure of first solution conduit (1A), the cut channel sheet (123) of bottom protrusion (111) extruding first solution conduit (1A) cover bottom of second solution conduit (1B), cut channel sheet (123) fracture in opened condition, second solution conduit (1B) bottom protrusion (111) is inserted and is entrenched in the pit (124) of first solution conduit (1A) cover bottom, rotate second solution conduit (1B), second solution conduit (1B) bottom protrusion (111) is from its bottom cut channel (114) fracture, liquid in second solution conduit (1B), flow out in the slit of from then on rupturing; Continue to insert second solution conduit (1B), the solution conduit exterior groove (112) of second solution conduit (1B) cooperates fixing with the solution conduit lid internal protrusion sealing ring (122) of first solution conduit (1A), and sealing can not be extracted;

Step 5, press the lid of second solution conduit (1B), the periphery raised seals ring (121) of its lid is cooperated with inner second groove of second solution conduit (1B) (113B), solution is extruded by the crack of second solution conduit (1B) bottom via in opened condition first solution conduit (1A) lid cut channel sheet (123) in the solution conduit, flow in following first solution conduit (1A), two kinds of test solutions are mixed into one;

Step 6, repeating step 3,4,5 can be mixed into one with more solution;

Step 7, above-mentioned first solution conduit (1A) that surpasses a solution conduit sample solution that is equipped with is installed in the counterbore shape interface (26) of connecting pipe, solution conduit bottom protrusion (111) contacts and presses connecting pipe bottom cut channel sheet (24), the stressed back of connecting pipe bottom cut channel sheet (24) cracking in opened condition, by the rotation solution conduit, solution conduit bottom protrusion (111) is from the annular cut channel fracture of connecting pipe bottom, continue to insert solution conduit, solution conduit exterior groove (112) is cooperated with solution conduit raised seals ring (21) form overhead structure, this solution conduit will oppositely be withstood to be and can not extract and sealing state by this overhead structure;

Step 8, press second solution conduit (1B), the lid periphery raised seals ring (121) of first solution conduit (1A) is cooperated with inner second groove of first solution conduit (1A) (113B), the slit that mixed solution is extruded by solution conduit bottom protrusion (111) fracture flows downward, through in opened condition connecting pipe bottom cut channel sheet (24) water conservancy diversion to following test paper, final biased sample solution is finished correlated response and is demonstrated signal such as color/fluorescent light in test strips, so far finishes test.