CN103191838A - Curved surface body container for plasma continuous separation - Google Patents
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- 238000000926 separation method Methods 0.000 title claims abstract description 181
- 210000000601 blood cell Anatomy 0.000 claims description 14
- 230000000739 chaotic effect Effects 0.000 claims description 8
- 210000002381 plasma Anatomy 0.000 abstract description 81
- 210000004369 blood Anatomy 0.000 abstract description 33
- 239000008280 blood Substances 0.000 abstract description 33
- 239000000306 component Substances 0.000 abstract description 24
- 239000012503 blood component Substances 0.000 abstract description 3
- 241001484259 Lacuna Species 0.000 abstract 6
- 230000007261 regionalization Effects 0.000 abstract 1
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- 238000013461 design Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 230000009471 action Effects 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
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Abstract
The invention relates to a curved surface body container used for plasma continuous separation. A separation lacuna is arranged inside the curved surface body container, blood is injected into the separation lacuna, the separation lacuna rotates at a high speed around the rotating shaft of the curved surface body container, blood components are separated by using centrifugal force according to density size, segmentation and regionalization are formed inside the separation lacuna, whole blood input is performed and visible components such as plasma, blood corpuscle and the like are respectively extracted out to achieve dynamical equilibrium, and continuous collection of a single component of plasma is achieved. In the invention, by optimally designing internal forms of the curved surface body container, closely linked to plasma flow rate, separation lacuna height, plasma separating factors, curve factors and the like, the thickness of the separation lacuna, particularly the thickness of a part close to a separation interface, is controlled, the curved surface body container is enabled to be more reasonable and has the advantage of improving single plasma collecting efficiency and quality.
Description
Technical Field
The invention relates to blood component separation, in particular to an idea and a design method for optimally designing a curved surface container in continuous centrifugal separation and collection of plasma, so that the curved surface container is more reasonable.
Background
Whether scientific research, medical clinical practice or industrial production, and more occasions, blood separation is needed, such as separation of single components from whole blood, separation of various single components from blood by centrifugation, and application of the single components in clinical treatment, scientific research or raw material preparation. It is most common to separate red blood cells, granulocytes, monocytes, platelets and plasma from whole blood by a centrifugal separation system or to separate red blood cells and a washing solution from a frozen red blood cell wash after thawing.
The working principle of the continuous centrifugal separation system is as follows: the main structure of the system comprises a centrifuge, an infusion pump and a controller device; introducing blood into a soft bag in a separation drum on a centrifuge through an infusion pipeline connected with an infusion pump, rotating the separation drum at a high speed, driving the soft bag to rotate at a high speed synchronously, leading the blood in the separation drum to have centrifugal sedimentation motion due to different actions of a centrifugal force field, and layering according to the density or specific gravity or sedimentation coefficient of the blood; when centrifugal sedimentation balance is achieved, the single component layers are arranged from the radial circumferential surface to the axial center from high density to low density to form a concentric circle shape, and then the separated single component layers are extracted by using an infusion pump.
The continuous collection of the blood single component in the system is realized by providing rotary power through a closed hose and playing a role in continuous input and extraction, one end of the hose is communicated with a separation soft bag in a separation drum and rotates at a high speed along with the separation drum, and the other end of the hose is fixed on a bracket, so that one end of the hose rotates and the other end of the hose is fixed, a disc tube structure is arranged in the middle of the hose to realize the unwinding and unwinding of the hose, the whole blood can be input into the rotating separation drum in a rotating state, and the single components such as plasma, blood cells and the like are extracted from the rotating separation drum. The separating drum, i.e. the separating disc, is combined with the coil structure to realize the continuous centrifugal separation of blood.
The prior art relates to a separation disc and coil structure for use in a continuous centrifugal blood separation apparatus, and is mainly described in US 5360542. In this patent, the separating disc is of a cylindrical configuration, called a separating drum, which has a cylindrical cavity therein, and a flexible bag is placed in the circular cavity to effect centrifugal separation of the blood; the coil pipe structure comprises a bottom frame, a rotatable top support, a separating drum suspended on the top support, a hose extending into the bottom of the separating drum from two bearings fixed on the side of the top support and passing through the case, and a square head at the end of the hose extending into a square groove at the central shaft of the separating drum. The hose is of a hollow structure, a plurality of conveying pipelines are arranged in the hose, and power supply and liquid conveying functions are realized simultaneously. Based on the structure, the power makes the top bracket rotate, drives the hose to unwind to generate torsional power, and transmits the torsional power to the separation drum to make the separation drum rotate in the same direction, thereby realizing the continuous centrifugal separation process of blood.
Another form of construction of a separation disc is disclosed in chinese patent application 200710046991.7. The patent states that: the separating disc on the mixed liquid separating system for multiple cell components includes one hard disc comprising inner core and base, one circular cavity with unsealed head and tail between the inner core and the base, and one disposable soft bag with single cavity structure with liquid inlet and outlet pipes and capable of being set inside the cavity. Because the centrifugal force at each position in the continuous cavity is not consistent, under the continuous action of the centrifugal force, each component of the mixed liquid is in a segmented distribution state in the soft bag, and a corresponding single component can be extracted from the segments. The inner core is equivalent to the inner separating cylinder, and the base is equivalent to the outer separating cylinder. The hard bottom disc is also called a separating disc.
Both foreign patents and domestic patents adopt a mode of adding a soft bag into a separating disc, and the soft bag is a disposable consumable part. In the actual use process, the two types of separation discs are different in design idea of blood separation, the former is designed as a concentric circle, the latter is designed as a non-concentric circle, and the separation efficiency of the latter is greatly improved compared with the former. The latter has a certain effect in practice, but still has room for improvement in design, although the design of the hard bottom plate and the separating soft bag is ingenious.
Disclosure of Invention
The invention aims to improve the prior art so as to effectively improve the efficiency of continuous centrifugal separation of plasma. The invention relates to a curved surface body container for continuously separating plasma, which can improve the efficiency and quality of plasma single collection in the continuous separation of the plasma.
In order to achieve the above purpose, the invention provides the following technical scheme:
a curved body container for continuous separation of plasma is characterized in that a separation cavity is arranged in the curved body container, the separation cavity is a curved body comprising an outer side wall and an inner side wall, and a curve projected by a curved surface of the outer side wall of the separation cavity on a plane vertical to a rotating shaft is represented as follows by polar coordinates:
wherein, the pole O of the polar coordinate is the intersection point of the rotating shaft and the plane, the polar axis L of the polar coordinate is the ray direction from the pole to the most proximal end of the curve, the positive direction of the angle of the polar coordinate is the counterclockwise direction, R is the polar diameter of any point on the curve, R is the polar diameter of the most distal end of the curve, and theta1Is the polar angle of the starting end of the curve, and has a value of 0 degree theta of the polar coordinate system2Critical radius F as a factor for curve separation from plasmarPolar angle of intersection, critical radius of plasma separation factor FrMinimum centrifuge radius, theta, required for plasma separation per unit time for rotational speed determination3Is a polar angle of value θ21.5 to 3.5 times of (theta)4The polar angle at the farthest end of the curve; in said separation cavity, [ theta ] is1,θ2) Is the plasma region, [ theta ]2,θ3) Is a chaotic region, [ theta ]3,θ4]Is the blood cell region, b1Curve coefficients for the plasma region, b2Is the curve coefficient of the chaotic region, b3Curve coefficients for the blood cell region; the curved surface shape of the inner side wall of the separation cavity can be the same as or different from that of the outer side wall, and theta2' critical radius F of separating factor for separating the curve of the inner side wall of the separation cavity from the plasmarPolar angle of the intersection point; different separation and collection effects can be achieved when the plasma area, the chaotic area and the blood cell area adopt different cavity thicknesses, but the average thickness of the front area and the rear area of the separation cavity close to the plasma separation interface is a design control parameter; the separation cavity is in [ theta ]2, θ2＇]The interval of (3) is a separation space area adjacent to a plasma separation interface, and the distance or the average distance D of projection curves of curved surfaces of the outer side wall and the inner side wall of a separation cavity gap in the interval on a vertical plane of a rotating shaft is as follows:
wherein K is constant and v is plasma [ theta ]2,θ2＇]Flow velocity in the interval, h being the height of the separation cavity in the direction of the axis of rotation, F (n)2R) separation cavity gap is [ theta ]2,θ2＇]Centrifugal force in the interval. The curved surface form of the outer side wall and the inner side wall of the separation cavity is [ theta ]2, θ2＇]The thicknesses of the separated cavities are equal when the intervals are the same, so that the distances between the projection curves of the curved surfaces of the outer side wall and the inner side wall of the separated cavity on the vertical plane of the rotating shaft are D; the curved surface form of the outer side wall and the inner side wall of the separation cavity is [ theta ]2, θ2＇]When the intervals are different, the thicknesses of the separated cavities are unequal, and the average distance between the projection curves of the curved surfaces of the outer side wall and the inner side wall of each separated cavity on the vertical plane of the rotating shaft is D.
The distance D is in the interval [ theta ]2, θ2＇]The plasma flow rate is proportional to the plasma flow rate, when the required separation efficiency is unchanged and the plasma flow rate is increased, the drag force action of the plasma axial flow on the visible components such as corpuscles and the like positioned near the separation interface is increased, so that the cavity volume of the interval can be increased by increasing the interval in the interval, the flow rate of the plasma in the interval is reduced, and the drag force action of the plasma axial flow on the visible components such as corpuscles and the like positioned near the separation interface is reduced.
The distance D is in the interval [ theta ]2, θ2＇]The separation cavity space is inversely proportional to the height of the separation cavity space, when the height of the separation cavity space is increased, the volume of the separation cavity space in the interval is increased, the staying time of the plasma in the interval is increased, and the separation efficiency is reduced, so that the volume of the separation cavity space in the interval is controlled by adjusting the interval to maintain the flow rate of the plasma in the interval.
The distance D is in the interval [ theta ]2, θ2＇]The inner part is inversely proportional to the arc length of the curved surface body, and the arc length of the curved surface body is increasedIn addition, the separation cavity volume of the interval is increased, the plasma staying time in the interval is increased, and the separation efficiency is reduced, so that the interval is adjusted to control the cavity volume of the interval so as to maintain the flow rate of the plasma in the interval.
The distance D and the separation cavity are in the interval [ theta ]2, θ2＇]The magnitude of the internal centrifugal force is inversely proportional. Under the condition that the flow rate of the plasma, the height of the curved surface body and the arc length are not changed, the centrifugal force is increased, the time for the plasma to stay in the interval can be reduced, and therefore the volume of a separation cavity in the interval is reduced by reducing the distance; the magnitude of the centrifugal force is proportional to the square of the rotational speed and proportional to the separation radius, so that as the rotational speed or separation radius increases, the compartment cavity volume can be reduced by decreasing the spacing.
Under the condition that the conditions such as rotating speed, separation radius, whole blood input flow rate, curved surface body arc length and the like are not changed, only the separation cavity gap is changed, and when the distance is widened, the plasma separation interface in the interval is diffused due to the widening of the plasma axial flow surface and the increase of unstable vortex generated by whole blood input, so that the separation effect and efficiency are directly influenced; when the distance is narrowed, the axial flow surface of the plasma is reduced, the flow speed is accelerated, the drag force of the axial flow of the plasma on the visible components such as blood cells is increased, the visible components such as the blood cells are dispersed and enlarged to the near end of the plasma area, and the separation effect is also influenced.
Based on the above disclosure, compared with the prior art, the method for continuously centrifuging blood according to the present invention has the following technical effects:
1. the invention provides an optimized design method of a curved surface body container for continuous centrifugal separation based on the thought in order to realize more efficient continuous centrifugal separation of blood, start from analyzing factors influencing the design of the curved surface body container in the continuous centrifugal separation process and confirm that the thickness of a separation cavity gap is an important factor in a design link, the curved surface container has one separating cavity capable of holding one separating soft bag, and the separating soft bag is adhered to the inner wall and the outer wall of the separating cavity to form separating space for blood to be separated in different density sections in the separating space, and the separating cavity has thickness to affect the plasma separating efficiency, therefore, the separation cavity in the curved-surface container is optimally designed, and the thickness of the separation cavity, particularly the thickness of the separation cavity close to the separation interface part, is controlled so as to improve the plasma separation efficiency.
2. The invention optimizes and controls the design parameters of the curved surface body container, further influences the plasma separation interface, realizes the purpose of improving the yield and the quality of the separation product without increasing the separation cost.
Drawings
FIG. 1 is a schematic diagram of a centrifugal separation system.
Fig. 2 is a schematic diagram of a curved body structure.
Fig. 3 is a diagrammatic view of the projection of the curved surface of the outer wall of the separation cavity onto a plane perpendicular to the axis of rotation.
FIG. 4 shows the curved form of the outer and inner sidewalls of the separation cavity at [ theta ]2, θ2＇]And when the intervals are the same, a curve spacing diagram is projected on a plane vertical to the rotating shaft.
FIG. 5 shows the curved form of the outer and inner sidewalls of the separation cavity at [ theta ]2, θ2＇]And when the intervals are different, the average spacing diagram of the projection curves on the vertical plane of the rotating shaft is shown.
Fig. 6 is a schematic sectional view of the separation cavity in the direction of the axis of rotation.
Detailed Description
The method for improving the efficiency of continuous centrifugal separation of plasma according to the present invention will be further described in detail with reference to the accompanying drawings and specific examples, so as to clearly understand the structural form and specific working procedures of the present invention, but the scope of the present invention should not be limited thereby.
The invention belongs to a design method of a curved surface body container for continuously separating blood plasma. As shown in fig. 1, the principle of this method is to place blood in a curved container having a separation cavity and to separate plasma from other formed components in the blood by rotating the separation container at high speed. The density difference in blood is at most red blood cells and plasma, where red blood cells have the highest density and plasma has the lowest density, and single component plasma and red blood cells are the largest blood components required in medicine. Therefore, continuous centrifugation of plasma in blood is the most basic and simple separation of components.
In order to improve the efficiency and quality of plasma single-component continuous separation and collection, the inner shape of a curved-surface container closely related to the plasma flow rate, the height of a separation cavity, the plasma separation factor and the curve coefficient is optimally designed, the thickness of the separation cavity, particularly the thickness of a part close to a separation interface is controlled, and the curved-surface container is more reasonable, as shown in figure 2, the separation cavity 3 comprises an outer wall 2 and an inner wall 1, and the curve of the curved surface of the outer wall of the separation cavity projected on a plane vertical to a rotating shaft is expressed by polar coordinates as follows:
as shown in fig. 3, a pole O of a polar coordinate is an intersection point of the rotation axis and the plane, a polar axis L of the polar coordinate is a ray from the pole to a curve start end, a positive direction of a polar coordinate angle is a clockwise direction, R is a polar diameter of any point on the curve, R is a polar diameter of a farthest end of the curve, and θ1Is the polar angle of the starting end of the curve, and has a value of 0 degree theta of the polar coordinate system2Critical radius F as a factor for curve separation from plasmarPolar angle of intersection, critical radius of plasma separation factor FrMinimum centrifuge radius, theta, required for plasma separation per unit time for rotational speed determination3Is a polar angleValue of θ21.5 to 3.5 times of (theta)4The polar angle at the farthest end of the curve; in said separation cavity, [ theta ] is1,θ2) Is the plasma region, [ theta ]2,θ3) Is a chaotic region, [ theta ]3,θ4]Is the blood cell region, b1Curve coefficients for the plasma region, b2Is the curve coefficient of the chaotic region, b3Curve coefficients for the blood cell region; the curved surface shape of the inner side wall of the separation cavity can be the same as or different from that of the outer side wall, and theta is2' critical radius F of separating factor for separating the curve of the inner side wall of the separation cavity from the plasmarPolar angle of the intersection point; different separation and collection effects can be achieved when the plasma area, the chaotic area and the blood cell area adopt different cavity thicknesses, but the average thickness of the front area and the rear area of the separation cavity close to the plasma separation interface is a design control parameter; the separation cavity is in [ theta ]2, θ2＇]The interval of (3) is a separation space area adjacent to a plasma separation interface, and the distance or the average distance D of projection curves of curved surfaces of the outer side wall and the inner side wall of a separation cavity gap in the interval on a vertical plane of a rotating shaft is as follows:
wherein K is constant and v is plasma [ theta ]2,θ2＇]Flow velocity in the interval, h being the height of the separation cavity in the direction of the axis of rotation, F (n)2R) separation cavity gap is [ theta ]2,θ2＇]Centrifugal force in the interval. The curved surface form of the outer side wall and the inner side wall of the separation cavity is [ theta ]2, θ2＇]The thicknesses of the separated cavities are equal when the intervals are the same, as shown in fig. 4, so that the distances 4 between the projection curves of the curved surfaces of the outer side wall and the inner side wall of the separated cavity on the vertical plane of the rotating shaft are D; the curved surface form of the outer side wall and the inner side wall of the separation cavity is [ theta ]2, θ2＇]When the intervals are different, the thicknesses of the separated cavities are unequal, and as shown in figure 5, the curved surfaces of the outer side wall and the inner side wall of each separated cavity project on the vertical plane of the rotating shaftThe average spacing 5 of the curves is D, and D1, D2, D3 in fig. 5 are the spacings separating three different locations of the cavity.
The distance D is in the interval [ theta ]2, θ2＇]The plasma flow velocity v is proportional to the plasma flow velocity, when the required separation efficiency is unchanged and the plasma flow velocity is increased, the drag force action of the plasma axial flow on the visible components such as corpuscles and the like positioned near the separation interface is increased, so that the interval is designed to be increased in the interval to increase the volume of the interval cavity, and the flow velocity of the plasma in the interval is reduced, so that the drag force action of the plasma axial flow on the visible components such as corpuscles and the like positioned near the separation interface is reduced.
The distance D is in the interval [ theta ]2, θ2＇]The separation cavity height h is inversely proportional to the separation cavity height, when the separation cavity height is increased, the separation cavity volume of the interval is increased, the plasma staying time in the interval is increased, and the separation efficiency is reduced, so that the separation cavity volume of the interval is controlled by adjusting the interval to maintain the flow rate of the plasma in the interval.
The distance D is in the interval [ theta ]2, θ2＇]The inner part is inversely proportional to the arc length of the curved surface body, when the arc length of the curved surface body is increased, the separation cavity volume of the interval is increased, the staying time of the plasma in the interval is increased, and the separation efficiency is reduced, so that the cavity volume of the interval is controlled by adjusting the interval to maintain the flow rate of the plasma in the interval.
The distance D and the separation cavity are in the interval [ theta ]2, θ2＇]Magnitude of internal centrifugal force F (n)2And r) is inversely proportional. Under the condition that the flow rate of the plasma, the height of the curved surface body and the arc length are not changed, the centrifugal force is increased, the time for the plasma to stay in the interval can be reduced, and therefore the volume of a separation cavity in the interval is reduced by reducing the distance; the magnitude of the centrifugal force is proportional to the square of the rotational speed and proportional to the separation radius, so that as the rotational speed or separation radius increases, the compartment cavity volume can be reduced by decreasing the spacing.
Under the condition that the rotating speed, the separation radius, the whole blood input flow rate and the arc length of the curved surface body are not changed, only the separation cavity gap is changed, and when the distance is widened, the plasma separation interface in the interval is diffused due to the widening of the plasma axial flow surface and the increase of unstable vortex generated by the whole blood input, so that the separation effect and the separation efficiency are directly influenced; when the distance is narrowed, the axial flow surface of the plasma is reduced, the flow speed is accelerated, the drag force of the axial flow of the plasma on the visible components such as blood cells is increased, the visible components such as the blood cells are dispersed and enlarged to the near end of the plasma area, and the separation effect is also influenced.
As shown in figure 6, the separation cavity can contain a separation soft bag, when the blood is full, the separation soft bag is jointed with the inner wall and the outer wall of the separation cavity to form a separation space, and the blood is sectionalized in the separation space formed by the curved surface according to different densities, so that the separation cavity in the curved surface container is optimally designed, the separation cost is not increased, and the yield and the quality of the separation product can be improved.
Example 1
The separation cavity of the curved surface body container in the embodiment is composed of an inner side wall of an outer separation disc and an outer side wall of an inner separation disc, the outer side wall of the separation cavity is the same as the curved surface of the inner side wall, and the distance D between the outer side wall and the inner side wall is as follows:
wherein the constant K is equal to 1.725 x 106The plasma flow rate is 80ml/min, the separation cavity height is 50mm, the curved surface body arc length is 120mm, b2=0.2，θ2=90 o，θ2＇=145 oWith a separation cavity gap of [90 ]o,145o]The centrifugal force in the interval is 2300g, giving a separation or average spacing of the separation cavities of 10 mm.
When the whole separation cavity is filled with whole blood, the whole blood is continuously input from the blood inlet, the blood plasma is continuously extracted from the blood plasma port and the blood cells and other tangible components from the blood cells port, the input amount and the output amount are equal, the total volume of the liquid in the separation cavity is kept balanced, and the purpose of continuously collecting the blood plasma can be realized.
It goes without saying that the method of continuous centrifugation of blood according to the invention can have other similar structural compositions and curvilinear forms in addition to those listed in the above examples. In summary, the scope of the present invention also includes other modifications and alternatives apparent to those skilled in the art.
Claims (3)
1. A curved body container for continuous separation of plasma is characterized in that a separation cavity is arranged in the curved body container, the separation cavity is a curved body comprising an outer side wall and an inner side wall, and a curve projected by a curved surface of the outer side wall of the separation cavity on a plane vertical to a rotating shaft is represented as follows by polar coordinates:
wherein,the polar axis L of the polar coordinate is a ray from the polar axis to the direction of the initial end of the curve, the positive direction of the angle of the polar coordinate is clockwise, R is the polar diameter of any point on the curve, R is the polar diameter of the farthest end of the curve, and theta1Is the polar angle of the starting end of the curve, and has a value of 0 degree theta of the polar coordinate system2Critical radius F as a factor for curve separation from plasmarPolar angle of intersection, critical radius of plasma separation factor FrMinimum centrifuge radius, theta, required for plasma separation per unit time for rotational speed determination3Is a polar angle of value θ21.5 to 3.5 times of (theta)4The polar angle at the farthest end of the curve; in said separation cavity, [ theta ] is1,θ2) Is the plasma region, [ theta ]2,θ3) Is a chaotic region, [ theta ]3,θ4]Is the blood cell region, b1Curve coefficients for the plasma region, b2Is the curve coefficient of the chaotic region, b3Curve coefficients for the blood cell region; theta2' projection curve of curved surface of inner side wall of separation cavity and critical radius F of plasma separation factorrPolar angle of the intersection point; the separation cavity is in [ theta ]2, θ2＇]The distance D between the projection curves of the curved surfaces of the outer side wall and the inner side wall of the separation cavity gap on the vertical plane of the rotating shaft in the interval is as follows:
wherein K is constant and v is plasma [ theta ]2,θ2＇]Flow velocity in the interval, h being the height of the separation cavity in the direction of the axis of rotation, F (n)2R) separation cavity gap is [ theta ]2,θ2＇]Centrifugal force in the interval.
2. The curved surface body container for continuous separation of plasma according to claim 1, wherein the curved surface form of the outer sidewall and the inner sidewall of the separation cavity is [ θ ]2, θ2＇]The same interval, the same thickness of separated cavities, the same fractionThe distances between the projection curves of the curved surfaces of the outer side wall and the inner side wall of the cavity gap on the vertical plane of the rotating shaft are D.
3. The curved surface body container for continuous separation of plasma according to claim 1, wherein the curved surface form of the outer sidewall and the inner sidewall of the separation cavity is [ θ ]2, θ2＇]When the intervals are different, the thicknesses of the separated cavities are unequal, and the average distance between the projection curves of the curved surfaces of the outer side wall and the inner side wall of each separated cavity on the vertical plane of the rotating shaft is D.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342420A (en) * | 1979-09-28 | 1982-08-03 | Gambro Dialysatoren Kg | Device for separating liquids, especially whole blood |
| US5360542A (en) * | 1991-12-23 | 1994-11-01 | Baxter International Inc. | Centrifuge with separable bowl and spool elements providing access to the separation chamber |
| US6277060B1 (en) * | 1998-09-12 | 2001-08-21 | Fresenius Ag | Centrifuge chamber for a cell separator having a spiral separation chamber |
| US20060240964A1 (en) * | 2005-04-21 | 2006-10-26 | Fresenius Hemocare Deutschland Gmbh | Method and apparatus for separation of particles suspended in a fluid |
| CN101172207A (en) * | 2007-10-12 | 2008-05-07 | 经建中 | Separator disk on multi-cell component mix liquid separating system and application method of the same |
| CN202526652U (en) * | 2012-01-09 | 2012-11-14 | 金卫医疗科技(上海)有限公司 | Curved surface container for controlling separation interface |
-
2012
- 2012-01-09 CN CN201210003575.XA patent/CN103191838B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342420A (en) * | 1979-09-28 | 1982-08-03 | Gambro Dialysatoren Kg | Device for separating liquids, especially whole blood |
| US5360542A (en) * | 1991-12-23 | 1994-11-01 | Baxter International Inc. | Centrifuge with separable bowl and spool elements providing access to the separation chamber |
| US6277060B1 (en) * | 1998-09-12 | 2001-08-21 | Fresenius Ag | Centrifuge chamber for a cell separator having a spiral separation chamber |
| US20060240964A1 (en) * | 2005-04-21 | 2006-10-26 | Fresenius Hemocare Deutschland Gmbh | Method and apparatus for separation of particles suspended in a fluid |
| CN101172207A (en) * | 2007-10-12 | 2008-05-07 | 经建中 | Separator disk on multi-cell component mix liquid separating system and application method of the same |
| CN202526652U (en) * | 2012-01-09 | 2012-11-14 | 金卫医疗科技(上海)有限公司 | Curved surface container for controlling separation interface |
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