CN103083376B - Can be used for the Rhizoma Ligustici extract for the treatment of rhinitis - Google Patents
Can be used for the Rhizoma Ligustici extract for the treatment of rhinitis Download PDFInfo
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Abstract
The invention provides a kind of can be used for treats the Rhizoma Ligustici extract of rhinitis, relates to aqueous solvent and extracts water extract that this (comprise MOBEN Ligusticumsinenseoliv not 11 distant MOBEN LigusticumjeholenseNakaietKit and Xinjiang this Conioselinumu of dish engrave inatum (Spreng.) Thell) plant of dish obtains, its preparation method, compositions containing this water extract and water extract and the compositions purposes for prevention and therapy rhinitis.Water extract comprises Coumarins, interior cruel class, alkaloid, Polyphenols, flavonoid, organic acid, skin class, saccharide.Experiment shows that extract is nontoxic, has effect of prevention or treatment rhinitis.
Description
Technical field
The present invention relates to Rhizoma Ligustici extract.Especially, the present invention relates to and extract with aqueous solvent the purposes that Rhizoma Ligustici (comprising Rhizoma Ligustici Ligusticum sinense Oliv and Rhizoma Ligustici Ligusticum jeholense Nakai et Kitag and Xinjiang Rhizoma Ligustici Conioselinum uaginatum (Spreng.) Thell) water extract that vegetable material obtains, its preparation method, compositions containing this water extract and water extract and compositions be used for the treatment of rhinitis.
Summary of the invention
The present invention adopts water and aqueous solution extract three kinds of Rhizoma Ligustici plants (comprising Ligusticum sinense Oliv and Ligusticumjeholense Nakai et Kitag and Conioselinum uaginatum (Spreng.) Thell) herb containing organic solvent to obtain extract.These three kinds of extracts have the effect of mice that stronger improvement egg protein (ova) induces and Cavia porcellus rhinitis, by literature search, have no Rhizoma Ligustici plant (comprising Ligusticum sinenseOliv and Ligusticum jeholense Nakai et Kitag and Conioselinum uaginatum (Spreng.) Thell) and study identical report with this, this research belongs to the activity that this plant of Late Cambrian has prevention or treatment rhinitis.
The present invention is embodied in the paragraph of following numbering:
1. prepare a method for the water extract of Rhizoma Ligustici, comprising: obtain Rhizoma Ligustici vegetable material; Extract Rhizoma Ligustici vegetable material with aqueous solvent, obtain the water extract of Rhizoma Ligustici.
2. the method for paragraph 1, wherein extracts Rhizoma Ligustici vegetable material with aqueous solvent and comprises: (1) extracts Rhizoma Ligustici vegetable material with aqueous solvent under proper condition; (2) liquid phase and solid phase is separated; (3) optionally, repeat step (1) and (2) one or many (such as repeat 1-several, 1-5 time, 1-2 time, 2-5 time, 3 times, 4 times); (4) optionally, liquid phase is merged; (5) liquid phase that optionally, will be obtained by step (2) or step (4) concentrates.
3. the method for paragraph 2, wherein described in step (1), felicity condition comprises: temperature is about 0-100 DEG C, and such as about 60-100 DEG C, preferred 90-100 DEG C, also can be about 0-60 DEG C; Pressure is about 0.1 atmospheric pressure-5 atmospheric pressure, such as about 0.5 atmospheric pressure-3 atmospheric pressure, such as about 1 atmospheric pressure, easily about normal pressure; Decocting time is at least about 0.15 hour, grows to such as 10 hours, such as about 0.15 hour-1 hour, about 0.5 hour-3 hours, such as about 0.5,1,2,3 hour, or wherein any time, is not preferably shorter than 1 hour; The w/v of Rhizoma Ligustici vegetable material and aqueous solvent is about 1: 1 to about 1: 100 (kg/liter), such as about 1: 1 to about 1: 50, about 1: 2 to about 1: 40, preferably approximately 1: 5 to about 1: 20, more preferably about 1: 5 to about 1: 15 (kg/liter); Preferably stir when soaking.
4. the method for any one of paragraph 2-3, be wherein separated in step (2) by filtering, centrifugal, natural subsidence etc. realizes.
5. the method for any one of paragraph 2-4, wherein the concentrated of step (5) is concentrating under reduced pressure, temperature can at about 0 DEG C to about 80 DEG C, preferably more than about 60 DEG C, such as room temperature is to about 60 DEG C, such as about 30-60 DEG C, as about 55 DEG C, step (5) can be lyophilization.
6. any one of paragraph 1-5 method, wherein said Rhizoma Ligustici is Ligusticum sinense Oliv and Ligusticum jeholense Nakai etKitag and Conioselinum uaginatum (Spreng.) Thell.
7. any one of paragraph 1-6 method, wherein said Rhizoma Ligustici vegetable material is the herb of Rhizoma Ligustici, such as root welding technology.
8. the method for any one of paragraph 1-7, wherein said aqueous solvent be the water of water or acidify or the water of alkalization or containing the aqueous solution of organic solvent or acidify or the aqueous solution containing organic solvent of alkalization; Wherein organic solvent can be methanol, ethanol, propanol, isopropyl alcohol, acetone or n-butyl alcohol or their any combination.
9. any one method of paragraph 1-7, wherein can use organic solvent extraction in advance before extracting Rhizoma Ligustici vegetable material containing aqueous solvent.Organic solvent includes but not limited to: petroleum ether, chloroform, ethyl acetate, ether, methanol, ethanol, propanol, isopropyl alcohol, acetone or n-butyl alcohol or their any combination etc.
10. the water extract of Rhizoma Ligustici.
The water extract of 11. paragraphs 10, its be by paragraph 1-9 any one method obtain.
12. water extracts of Rhizoma Ligustici obtained by any one method of paragraph 1-9.
13. 1 kinds of compositionss, it contains any one Rhizoma Ligustici water extract of paragraph 10-12.
The compositions of 14. paragraphs 13, it is also containing excipient or carrier.
The compositions of 15. paragraphs 13 or 14, it is pharmaceutical composition, health composition or beverage composition for treating dental erosion.
16. paragraph 10-12 any one Rhizoma Ligustici water extract or paragraph 13 or 14 compositions for the preparation for the treatment of rhinitis in purposes.
17. Rhizoma Ligustici vegetable materials or its extract (preferential water extract) are for the production of the purposes that can be used for treating in the compositions of rhinitis.
The purposes of 18. paragraphs 16, wherein said compositions is pharmaceutical composition, health composition, food compositions or beverage composition for treating dental erosion.
The method of 19. treatment rhinitis, comprises and gives Rhizoma Ligustici vegetable material or its extract (preferred water extract) or the product after having Rhizoma Ligustici vegetable material to process containing this extract or other to patient.
Compositions or the other side of this extract thing of the present invention will be described hereinafter, but they not should be understood to limit the scope of the present invention.
Accompanying drawing explanation
Without accompanying drawing
Detailed description of the invention
The present invention's object obtains Rhizoma Ligustici plant (comprising Ligusticum sinense Oliv and Ligusticum jeholense Nakai et Kitag and Conioselinum uaginatum (Spreng.) Thell) water extract and contains the water extract of organic solvent and the water extract containing organic solvent, and these extracts are due to treatment of rhinitis.
Therefore, first aspect, the present invention relates to a kind of method preparing the water extract (or extractum) of Rhizoma Ligustici, comprising: obtain Rhizoma Ligustici vegetable material.Have containing aqueous solvent extract (or leaching) Rhizoma Ligustici vegetable material.Obtain the water extract of Rhizoma Ligustici.Method of the present invention is used for from Rhizoma Ligustici vegetable material, extract the active component that can be used for treating rhinitis.
(or leaching) Rhizoma Ligustici vegetable material is extracted by decocting method, leaching method, percolation or steam distillation etc.
In a specific embodiment, comprise with aqueous solvent extract Rhizoma Ligustici vegetable material: (1) decocts Rhizoma Ligustici vegetable material with aqueous solvent under suitable condition; (2) liquid phase and solid phase is separated; (optionally, repeat step (1) and (2) one or many (such as repeat 1-several, 1-5 time, 1-2 time, 2-5 time, 3 times, 4 times); (4) optionally, liquid phase is merged; (5) liquid phase that optionally, will be obtained by step (2) or step (4) concentrates.
In step (1), described felicity condition is determined by test.Temperature is about 0-100 DEG C, and such as about 60-100 DEG C, preferred 90-100 DEG C, also can be about 0-60 DEG C; .About 0.1 atmospheric pressure of pressure-5 atmospheric pressure, such as about 0.5 atmospheric pressure-3 atmospheric pressure, such as an about atmospheric pressure, is about normal pressure easily.Decocting time is at least about 0.15 hour, grows to such as 10 hours, such as about 0.15 hour-1 hour, about 0.5 hour-3 hours, such as about 0.5,1,2,3 hour, or wherein any time, is not preferably shorter than 1 hour; The w/v of Rhizoma Ligustici vegetable material and aqueous solvent is about 1: 1 to about 1: 100 (kg/liter), such as about 1: 1 to about 1: 50, about 1: 2 to about 1: 40, preferably approximately 1: 5 to about 1: 20, more preferably about 1: 5 to about 1: 15 (kg/liter); Preferably stir when soaking.
Separation in step (2) realizes by any method known in the art, includes but not limited to, filters, centrifugal, natural subsidence etc.The concentrated of step (5) realizes by any method known in the art.This concentrating has no particular limits, and prerequisite does not destroy active component.Such as, this is concentrated can be concentrating under reduced pressure.Temperature can at about 0 DEG C to about 80 DEG C, and such as about room temperature is to about 80 DEG C, preferably more than about 60 DEG C; Such as about 0 DEG C to about 60 DEG C; Such as about 50-60 DEG C, as about 55 DEG C.The concentrated of step (5) also can be lyophilization.
A kind of common method is evaporation, such as atmospheric evaporation, reduction vaporization, thin film evaporation etc.
Drying can be carried out, such as constant pressure and dry, drying under reduced pressure, spraying dry, lyophilization etc. after after concentrated.Drying is not necessary step, but preferred in certain embodiments.
In some embodiment, concentration step also can omit.Such as, directly can use leachate, such as, take or directly contain as raw material preparation the compositions of Rhizoma Ligustici directly to patient.
Water extract of the present invention (extractum as after decoction liquor or concentrate drying) can also carry out purification further.This can adopt in many purification process known in the art one or more carry out.In purge process, the existence of best detection active component.
In the present invention, described Rhizoma Ligustici vegetable material can be Ligusticum sinense Oliv and Ligusticum jeholense Nakai et Kitag and Conioselinum uaginatum (Spreng.) Thell or their combination.
In the inventive method, described Rhizoma Ligustici vegetable material can be Rhizoma Ligustici plant Herb or any part, such as its organ, tissue or cell, comprises flower, fruit, seed, stem, leaf, root, preferably the under ground portion of Rhizoma Ligustici, as root welding technology.Rhizoma Ligustici vegetable material can be medical material, also can be crude drug.Rhizoma Ligustici vegetable material can be tissue culture, cell culture.Rhizoma Ligustici plant can be natural or genetically modified.Rhizoma Ligustici material can be dry or fresh.
In extracting method of the present invention, described Rhizoma Ligustici vegetable material can be through pretreated.These process comprise physical treatment, chemical treatment, biological treatment etc.Such as: Rhizoma Ligustici vegetable material can be simply wash in advance, pulverize.In one embodiment, organic solvent extraction can be used in advance before extracting Rhizoma Ligustici vegetable material with aqueous solvent.Organic solvent includes but not limited to: petroleum ether, chloroform, ethyl acetate, ether, methanol, ethanol, propanol.Isopropyl alcohol, acetone or n-butyl alcohol or their any combination etc., as ether, as ethanol as 95% ethanol.
In the present invention, described " aqueous solvent " is any moisture solvent, and it can be water or the aqueous solution containing organic solvent; Wherein organic solvent can be methanol, ethanol, propanol, acetone or n-butyl alcohol or their any combination.Water can be such as distilled water, ion exchange water or tap water.Aqueous solvent can also with the addition of the extraction water of suitably other material.Other material can be such as organic solvent, buffer agent, acid or alkali etc.Preferably, described moisture or containing the aqueous solution of organic solvent.In aqueous solvent, the content (volume ratio) of water can be such as at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% or higher, preferably at least about 10%, more preferably at least about 20%, 50% or more.
On the other hand, the present invention relates to the water extract (or water extraction) of Rhizoma Ligustici.
Rhizoma Ligustici of the present invention " water extract (or water extraction) " refers to by with aqueous solvent (as water or the water containing organic solvent), the Rhizoma Ligustici extract extracted from Rhizoma Ligustici vegetable material, this Rhizoma Ligustici extract thing can be used for treating rhinitis.
Water extract of the present invention can be obtained by extracting method of the present invention defined above.
On the other hand, the present invention relates to the water extract of the Rhizoma Ligustici obtained by any one method of the present invention.
Such as, extract (or leaching) Rhizoma Ligustici vegetable material by decocting method, infusion process, percolation or steam distillation etc., obtain leachate.Then, optionally carry out concentrating, dry or purification or their any combination.
Gained extractum or purified product can be mixed with object compositions, further as pharmaceutical composition, health composition, food compositions or beverage composition for treating dental erosion.
Main containing coumarin, lactone, alkaloid, polyphenol, flavone, organic acid, sugar and peptide constituents in extract of the present invention.
Extract of the present invention has the effect improving allergic rhinitis, and it can be used for the medicine preparing Prevention or treatment rhinitis, comprises oral medicine and injection, also can prepare health product.
On the other hand, the present invention relates to the compositions containing Rhizoma Ligustici water extract of the present invention.Preferably, said composition is also containing excipient or carrier.
In a particular embodiment, described compositions is pharmaceutical composition, health composition, food compositions or beverage composition for treating dental erosion.
The method that Rhizoma Ligustici water extract of the present invention is mixed with object compositions is known in the art.According to different needs, those skilled in the art of the invention can select suitable additive, compound method, dosage form, unit dose etc.
When the present composition is pharmaceutical composition, can containing suitable pharmaceutical excipient, carrier or diluent.The known technology of pharmaceutical field can be adopted to carry out preparation.
Pharmaceutical composition of the present invention can adopt multiple dosage form, and this often depends on route of administration.Such as, Rhizoma Ligustici water extract of the present invention may be used for the medicine preparing treatment rhinitis, comprises the preparation of oral medicine and parenteral, as injection.Drug regimen of the present invention can pass through number of ways administration, such as oral, parenteral etc.Dosage regimen mediating recipe amount depends on many factors, as route of administration, patient health situation etc., and can be determined by doctor.Dosage range can be determined by normal experiment by those skilled in the art.
On the other hand, the present invention relates to the purposes of compositions in the medicine for the preparation for the treatment of rhinitis of Rhizoma Ligustici extract or Rhizoma Ligustici water extract.
On the other hand, the present invention relates to Rhizoma Ligustici vegetable material or its extract (preferred water extract) for the production of the purposes that can be used in the compositions of rhinitis.Described compositions is preferably pharmaceutical composition, health composition, food compositions or beverage composition for treating dental erosion.On the other hand, the present invention relates to a kind of method for the treatment of rhinitis, comprise and give Rhizoma Ligustici vegetable material or its extract (comprising water extract) or the compositions containing this extract to patient or other is by the product after Rhizoma Ligustici materials processing.
" patient " comprises any animal, preferred mammal, particularly house pet, letting animals feed.In a preferred embodiment, patient is people." patient " suffers from or suspects the individuality or normal individual of suffering from rhinitis.Therefore, Rhizoma Ligustici vegetable material of the present invention or extract (preferred water extract) or the compositions containing this extract or other processed by Rhizoma Ligustici vegetable material after the purposes of product not only comprise treatment, also comprise prevention rhinitis.
Embodiment 1
Rhizoma Ligustici (Ligusticum sinense Oliv) root and rhizome 1kg, adds 95% ethanol 8L reflux, extract.Filter, merging filtrate, centrifugal, supernatant 45 DEG C of concentrating under reduced pressure to ethanol extraction extractum 51 grams, yield 5.1%.Residue 1kg after ethanol extraction distilled water 8L decocts 1hr, and residue decocts twice with 4L distilled water at every turn continuously, each 1hr, and filter, merging filtrate, concentrating under reduced pressure, dries to obtain the water extracted immersing paste 110.3 grams, yield 11.03% for 55 DEG C.
Rhizoma Ligustici (Ligusticum jeholense Nakai et Kitag) root and rhizome 1kg adopts same method to extract, alcohol extract yield 4.8%, water extraction extract yield 10.2%.
Xinjiang Rhizoma Ligustici (Conioselinum uaginatum (Spreng.) Thell) root and rhizome 1kg adopts same method to extract, alcohol extract yield 5.5%, water extraction extract yield 12.3%
Embodiment 2
Carry out qualitative reaction to the water extract of three kinds of Rhizoma Ligusticis, analysis result is as follows:
Qualitative examination result shows in these two kinds of Rhizoma Ligustici water extracts all containing coumarin, lactone, alkaloid, polyphenol, flavone, organic acid, sugar and peptides.
Embodiment 3
Rat is divided into 6 groups at random, often organizes 10, be respectively blank group, model group, the high, medium and low dosage group of medicine Rhizoma Ligustici and hismanal group.Except blank group gives isopyknic normal saline, other 5 groups with 0.3mg, Al (OH) 3300mg, add the suspension lumbar injection that 1ml normal saline is made, 1 time every other day, totally 8 times.With 5%OVA normal saline solution collunarium from the 16th day, every side nostril 50ul, every day 1 time, altogether.10 times.Normal group replaces with isopyknic normal saline.After collunarium excites, the number of times observing rat sneeze in 30min, the intensity of scratching nose, observation draw nasal cavity secretions repeatedly with filter paper after terminating, and the difference before and after drawing counts nasal secretion amount.Adopt the addition method to calculate total score, total score surpasses 6 and is divided into model success.Rhinocnesmus: without scratching 0 point, nose, slightly scratching 1 point, nose, frequently scratching 2 points, nose (10 ~ 20 times per minute), scratch more than 3 points of nose; Sneeze: without sneeze 0 point, sneeze 1 ~ 31 point, is greater than 11 3 points by 4 ~ 10 2 points; Nasal mucus: without 0 point, nasal mucus, flow to prenaris 1 point, exceeds prenaris 2 points, full 3 points of nasal mucus stream.After model success, gavage gives Rhizoma Ligustici (Ligusticumsinense Oliv) high dose group 1g/kg, middle dosage group 0.5g/kg, low dose group 0.25g/kg (amount of water extract is calculated by the gauge of the water extract extractum of embodiment 1), hismanal group 0.3mg/kg, successive administration 10 days.The results are shown in Table 1,2,3,4
Table 1 rat sneeze number compares
###p < 0.001 compares with model group compared with blank group
*p < 0.01
During table 2 administration, rat scratches nose strength ratio comparatively
###p < 0.001 compares with model group compared with blank group
*p < 0.01
Table 3 rat nasal secretion
###p < 0.001 compares with model group compared with blank group
*p < 0.01
The table of integrals before and after the administration of table 4 rat
| Group | n | Dosage | Integration before administration | Integration after administration |
| Normal group | 10 | - | 4.31±2.31 | 4.42±2.62 |
| Model group | 10 | - | 7.69±3.68 | 8.21±4.32# |
| Low dose group | 10 | 0.25g/kg | 7.88±3.81 | 5.12±3.62 * |
| Middle dosage group | 10 | 0.5g/kg | 7.29±3.43 | 4.80±3.21 * |
| High dose group | 10 | 1g/kg | 7.90±3.84 | 4.68±3.72 * |
| Hismanal group | 10 | 0.3mg/kg | 7.63±4.08 | 4.53±3.24 * |
#p < 0.05 compares with model group compared with blank group
*p < 0.05
Table 5 rat blood serum histamine, IgE content
| Group | n | Dosage | Histamine (mg/L) | IgE(pg/ml) |
| Normal group | 10 | - | 6.13±0.68 | 27.69±2.31 |
| Model group | 10 | - | 13.38±1.29### | 63.38±4.96### |
| Low dose group | 10 | 0.25g/kg | 7.58±0.82 * | 43.88±3.63 ▲ |
| Middle dosage group | 10 | 0.5g/kg | 6.95±0.76 ** | 39.47±3.21 ▲▲ |
| High dose group | 10 | 1g/kg | 6.42±0.68 ** | 32.43±2.98 ▲▲ |
| Hismanal group | 10 | 0.3mg/kg | 6.28±0.70 ** | 30.97±2.68 ▲▲ |
###p < 0.001 compares with model group compared with blank group
*p < 0.05,
*p < 0.01;
▲p < 0.05,
▲ ▲p < 0.01
Embodiment 4
Rhizoma Ligustici water extract 200g, medical starch is appropriate, and both fully mix, encapsulated, make 100 capsules, and every heavy 0.25 gram, containing Rhizoma Ligustici water extract 200 milligrams.
Claims (2)
1. the water extract of Rhizoma Ligustici vegetable material is as the purposes of sole active agent in the compositions for the preparation of prevention or treatment rhinitis, and wherein, water extract is obtained by following steps: Rhizoma Ligustici root and rhizome 1kg, adds 95% ethanol 8L reflux, extract; Filter, merging filtrate, centrifugal, supernatant 45 DEG C of concentrating under reduced pressure are to ethanol extraction extractum; Residue 1kg after ethanol extraction distilled water 8L decocts 1hr, and residue obtained each 4L distilled water decocts twice, each 1hr continuously, and filter, merging filtrate, concentrating under reduced pressure, dries to obtain water extract extractum for 55 DEG C.
2. purposes according to claim 1, wherein said compositions is pharmaceutical composition, health composition, food compositions or beverage composition for treating dental erosion.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1265909A (en) * | 1999-03-03 | 2000-09-13 | 朱维新 | Capsule for treating rhinitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1265909A (en) * | 1999-03-03 | 2000-09-13 | 朱维新 | Capsule for treating rhinitis |
Non-Patent Citations (2)
| Title |
|---|
| 滇藁本中黄酮类化合物的提取工艺;段利平等;《云南中医中药杂志》;20120229;第33卷(第1期);53-55 * |
| 辛花口服液的疗效观察;赵爱华等;《新世纪全国中药研究暨中药房管理学术研讨会论文汇编》;20011231;136-137 * |
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