CN103052418A

CN103052418A - Dry powder inhaler

Info

Publication number: CN103052418A
Application number: CN2011800335758A
Authority: CN
Inventors: M·巴耶; Z·萨拉克
Original assignee: Valois SAS
Current assignee: Aptar France SAS
Priority date: 2010-07-07
Filing date: 2011-07-05
Publication date: 2013-04-17
Anticipated expiration: 2031-07-05
Also published as: FR2962341A1; CN103052418B; WO2012004524A1; FR2962341B1

Abstract

Dry powder inhaler having a substantially cylindrical body (210), the cylindrical wall of said body (210) comprising a mouthpiece (230) defining the dispensing opening (231), and a loading opening (220) for receiving a capsule (10) containing a dose of dry powder, said body (210) being provided, on the first axial end part thereof, with a first grip part (270) fixed with respect to said body and, on the second axial end part thereof, a second grip part (260) mounted on said body in such a way that it can move between two end positions, said second grip part (260) having a central shaft (261) that supports a projection (265) designed to open a capsule (10) inserted into said loading opening (220), when said second grip part (260) is rotated between the two end positions thereof.

Description

Dry powder inhaler

Technical field

The present invention relates to a kind of dry powder inhaler.

Background technology

Inhaler is being known in the art.There is different types of inhaler.First kind inhaler comprises the container that holds many powder dose, and described inhaler is provided with dosing member, can separate this powder of a dosage from container when each the actuating, so that this dose powder is taken in the discharge line, in order to distribute to user.The inhaler of another type is powder dose is arranged in the single container of predetermined close, then opens in these containers when each actuated inhaler.This implements to guarantee the better sealing of powder, because each dosage only just is opened in the moment of its discharge.In order to realize these single containers, various modification have been proposed, such as a microscler blister strip or be arranged in some vesicles on the rotating circular disk.The inhaler of above-described any type with existing has and their structure and the merits and demerits relevant with their operation.Therefore, for some inhaler, its problem is to decide when activating accuracy and the repdocutbility of dosage at every turn.Equally, the effectiveness of distribution that is to say effectively to be penetrated in the user pulmonary to obtain the dosage part of useful therapeutic effect, also is the problem that the inhaler of some has.About opening of single container, proposed to peel off or open confining bed.This shortcoming that has be difficult to control to apply in order to guarantee to open fully but without the power of opening the danger of next container, if device for opening needs activate by sucking especially.Another problem that the inhaler of outfit blister strip has is relevant with the storage of the used part of the movement of band and band.Therefore, according to the length of band and/or the thickness of vesicle, large space can be proved to be the good operation that any clamping stagnation essential and blister strip can hinder inhaler.In addition, when the forward gear of band when simultaneously the leading section of traction belt is bad to avoid coiling, along with actuating, especially because increasing gradually with the diameter of being with of coiling can cause problem.Therefore, multi-dose inhaler and the normally complicated device of the inhaler with blister strip, it is comprised of a large amount of parts, and the cost height of therefore making and assembling.In order to realize so also complicated so the not high device of cost, proposed to have for example inhaler of bladder of single container, bladder just in time was loaded into inhaler before using inhaler.The advantage of this class device is the inside that does not need all dosage is stored in equipment, so that the size of equipment can reduce.By contrast, use more complicated the inhaler because user must be before each the use be packed a bladder into.In addition, other proprietary shortcoming of this class bladder formula inhaler also shows.Therefore, this class device is comprised of two parts usually, and one of them parts is equipped with the termination, oral cavity.When this class device of operation, in order to open bladder and to discharge powder, perhaps in order to discharge empty bladder after sucking, the finger of user contacts with the termination, oral cavity usually, and this can have the risk of infection.Equally, in order to discharge empty bladder, device will be opened usually, and this interior exposed that makes device is in any external contamination, and when sucked next time, external contamination was easily passed to user subsequently.Document US 2004/255940 has been described a kind of prior-art devices.

Summary of the invention

Target of the present invention is in order to propose a kind of dry powder inhaler, and it no longer produces above-mentioned shortcoming.

Especially, target of the present invention is to propose such inhaler, and the cost of its manufacturing and assembling is low and simple, be easy to use, and as much as possible restriction is infected and/or the risk of pollution.

Therefore, target of the present invention is a kind of dry powder inhaler, it has the main body of basic cylindricality, described main body has the termination, oral cavity of definition dispensing orifice on the one hand on its cylindricality wall body, has on the other hand the loading port that holds the bladder of a dosage dry powder for reception, described main body partly locates to be equipped with first retained part fixing with respect to described main body at its first axial end portion, and partly locate to be equipped with in rotation between two end positions at its second axial end portion and be installed on the second retained part on the described main body, described the second retained part has the axis of centres, the axis of centres supports a projection, at described the second retained part between two end position during rotary moving, projection is suitable for opening the bladder that is inserted in the described loading port, described the first retained part have be provided with window axially close wall body, the described axis of centres supports a valve component, valve component forms closing component and is connected with described the second retained part aspect rotation, described valve component has an axial wall that is provided with window, the window of axial wall cooperates with the wall body of axially closing of the first retained part, so that in an end position of the second retained part, described window aligns to open the dispersion chamber, and in another end position of the second retained part, described window staggers each other angularly, so that described dispersion chamber is closed.

Advantageously, described main body has opening, and described valve component has by the visible suitable indicateing arm of described opening, is used to indicate in one or the other end position that the user inhaler is in described the second retained part.

Advantageously, described main body and/or described the second retained part have suitable labelling, are used to indicate in one or the other end position that the user inhaler is in described the second retained part.

Advantageously, described dispersion chamber has around the shape of the basic annular of the described axis of centres.

Advantageously, described dispersion chamber and/or the described hollow axis of centres have the inlet port of air, allow to produce when sucking to replenish air flow, so that powder was disperseing intracavity to carry out more eddying motion before it is inhaled into.

Advantageously, the inlet port of described air is implemented in the cylindricality wall body of main body in tangential mode.

Advantageously, the described axis of centres is hollow, and is disperseing intracavity, especially having at least one opening near described prominence.

Advantageously, termination, described oral cavity is equipped with aperture plate, passes described dispensing orifice in order to the part that stops bladder and discharges.

Description of drawings

By the detailed description of doing below with reference to the accompanying drawing that provides as limiting examples, these characteristics of the present invention and advantage and its its feature and advantage will show clearlyer, in the accompanying drawing:

-Fig. 1 is the schematic, exploded perspective view of the distributor of one favourable embodiment according to the present invention;

-Fig. 2 a is the cross-sectional schematic view of device before bladder is packed into of Fig. 1;

-Fig. 2 b is the explanatory view of the axial end surface of main body, and it is illustrated in the emptying opening that forms in the position of Fig. 2 a;

-Fig. 3 a and 3b be and Fig. 2 a and the similar view of 2b, but when bladder is opened beginning;

-Fig. 4 a and 4b be and Fig. 2 a and the similar view of 2b, but in the bladder opening procedure;

-Fig. 5 is and the similar view of Fig. 2 a, but after bladder is opened and before sucking;

-Fig. 6 is and the similar view of Fig. 5, but in suction process;

-Fig. 7 is similarly but along the view of another cutting line with Fig. 6;

-Fig. 8 is and the similar view of Fig. 6, but after sucking and before next bladder is packed into;

-Fig. 9 is and the similar view of Fig. 8, but after next bladder is packed into; With

-Figure 10 be the device of Fig. 1 along the explanatory view of another cross section, it is illustrated in the discharge of the bladder of the sky in the position of Fig. 9.

The specific embodiment

Accompanying drawing illustrates one embodiment of the present invention.Fig. 1 especially illustrates the decomposition diagram of device.In this embodiment, inhaler 200 only is made of three parts.The main body 210 of basic cylinder body shape is provided with the termination, oral cavity 230 of definition dispensing orifice and is suitable for receiving the loading port 220 of bladder 10 at the periphery of this main body.The inside definition one that this main body 210 has vertical axis of centres and cylindrical bodies 210 disperses chamber 211.The first axial end portion part of described main body 210 is formed by relative main body 210 the first fixing retained parts 270.This first retained part can be formed simply by the axial edge of described main body.Advantageously, go out as shown, this first retained part 270 has special outline, passes through the first retained part operating means in order to impel user.This first retained part 270 have disperse chamber 211 close wall body 271, the described wall body 271 of closing has an opening 275, this opening for example extends in described closing in the wall body 271 in about 60 ° to 90 ° angle.At opposite side, main body 210 is opened, and this opening is closed by the second retained part 260 of installing with respect to described main body 210 rotations.The second axial end portion part of this second retained part 260 thereby formation main body.Advantageously, this second retained part 260 has and the similar outline of the outline of the first retained part 270.Therefore, naturally impel user to catch each retained part 260,270 with corresponding hands, and make one with respect to another rotation, with operating means.Inside in cylindrical bodies 210, in this first axial end portion part one side, be furnished with closing component, for example valve component 250, valve component also has the axial wall 251(paroi axiale that is provided with window 255), the size of window is approximately corresponding with the window 275 of implementing in the wall body 271 closing of main body 210.This valve component 250 is installed on the axis of centres 261 that engages with described the second retained part 260 being connected aspect the rotation.For example, shown on Fig. 1, the rib 263 that is formed on the end 262 of the axis of centres 261 cooperates with the groove 257 of described valve component 250.Thereby valve component 250 is connected aspect rotation with the second retained part 260 of device.Valve component 250 is disposed in the inside of main body 210, is used for cooperating with the wall body 271 of closing of main body.Therefore, as below will be more explaining in detail, in order to use the device of this embodiment, user is with its two hand-tight two retained

parts

260 and 270 and they are relative to each other rotated of holding to.User needn't be forced to contact oral cavity end portion 230 for operative installations at any time.

Fig. 2 a, 3a and 4a illustrate the stage that bladder 10 is packed into and opened.Therefore, by more particularly with reference to Fig. 2 a, as seen pass across the cross section of main body 210 and therefore as seen disperse chamber 211, loading port 220 and termination, oral cavity 230, and be rotatably mounted on the axis of centres placed in the middle 261 in the described dispersion chamber 211.During user is packed bladder 10 into described loading port 220 along arrow A.The degree of depth in described hole 220 is adjusted to, and when user inserted bladder 10 in the described loading port 220 fully, the upper part 11 of bladder was held tightly to restraint in described loading port 220, and the lower part 12 of bladder is protruded in the inside that disperses chamber 211.At this moment, user will be with respect to the first retained part 270, also therefore with respect to main body 210 rotations the second retained part 260.This rotation is illustrated on Fig. 3 a and the 4a.As especially visible on Fig. 1, the axis of centres 261 is provided with projection 265, for example the projection of ligule.Upper visible such as Fig. 3 a and 4a, when making the second retained part 260 with respect to main body 210 rotation, described projection 265 will contact with the lower part 12 of bladder.Fig. 3 a illustrates the just in time position before bladder is opened, and Fig. 4 a illustrates the bladder of utilizing projection 265 to promote the lower part 12 of bladder and being in opening procedure.The rotation of the first axle 261 causes the rotation of projection 265 as can be known, and projection will make the lower part distortion of bladder, and therefore the lower part of bladder will separate with the upper part 11 of bladder, and the upper part of bladder still fixes in loading port 220.Fig. 5 illustrates such position: bladder 10 is opened, and part 11 fixes in loading port 220 and its underpart 12 freely falls into and disperses in the chamber 211 on it, in order to disperseing intracavity to be drained.Fig. 2 b, 3b and 4b are illustrated in the first axial end portion of main body and partly locate, especially disperseing the variation that wall body 271 places occur of closing in chamber.Therefore, in the position of Fig. 2 a, in packing into constantly of bladder 10, the window 255 of the axial wall 251 of valve component 250 is faced mutually with the window 275 of closing wall body 271.When user will rotate the second retained part 260, he also will rotate valve component 250, because valve component is fixed on operation part 260 aspect rotation.Therefore, axial wall 251 parts will little by little be sealed the opening of axially closing wall body 271 275 of main body 210.Shown in Fig. 3 b is just before bladder begins to be opened, and also has a bit open passage, in case and the bladder distortion, shown in Here it is Fig. 4 b was upper, opening was fully closed, and disperseed the inside in chamber 211 so was closed.Therefore, fracture and powder drains into the moment of disperseing in the chamber 211 in bladder, the dispersion chamber is closed at its axial end portion wall body place.

Therefore, shown in the arrow B on Fig. 6, user can suck.For this reason, user makes its mouth be trapped among around the termination, oral cavity and produces inlet flow, and inlet flow will make user suck through dispensing orifice 231 and be contained in the powder that disperses in the chamber 211.The basic annular shape that centers on the dispersion chamber 211 of the axis of centres 261 is favourable, and this is: this shape is beneficial to the eddying motion from the inlet flow of termination, oral cavity.The termination, oral cavity preferably has aperture plate 237, aperture plate be used for allowing powder by but stop bladder partly to be discharged to the user mouth.The inlet flow that is produced by user will make part 12 eddying motions under the bladder of disperseing intracavity section freely to rotate.This again guarantees under the described bladder the emptying of part and allows the fine dispersion of powder when it is dispensed to user and not coalescent.This eddying motion is illustrated by the arrow C on Fig. 6.Fig. 7 illustrates device along a cutting line that diverges to a little, as on Fig. 7 as seen, disperse chamber 211 to have one or more tangential openings 218 that are arranged in the main body 210.This is conducive to the eddying motion of inlet flow, because in the moment that user sucks, it passes inspiration the air flow (arrow D) of these tangential openings 218, air flow therefore nature will described dispersion chamber 211 inner rotation and thereby also make further lower part 12 eddying motions of bladder so that powder disperses and is not coalescent.

Advantageously, the axis of centres 261 has the opening 269 that for example is arranged in around the projection 265.This illustrates at Fig. 1, but also can other opening 269 be set along axle 261.These openings have dual function.On the one hand, replenish entering of air when they allow to suck, and therefore also produce and be conducive to more again that bladder is emptying, powder is not coalescent and the not homogeneous turbulence of eddying motion.On the other hand, the hole of arranging near projection 265 guarantees that the lower part 12 of bladder can not be enclosed within to be made powder stagnate to amass in described prominence on the described projection 265.Suppose that part is enclosed within on the described projection 265 under this bladder, in case user sucks, will drive away described bladder part with passing the air flow that passes through in described hole 269.

After sucking, preferably, user makes device return its starting position by making the second retained part 260 with respect to the main body counter-rotation.Do like this, user will be opened the window 275 of axially closing wall body 271 again, and the

window

255 and 275 that therefore allows the lower part 12 of bladder to pass alignment is discharged.Shown on Fig. 8, when user is put into next bladder 10 in the loading port 220, user will be shifted the upper part 11 that still fixes the formerly bladder in loading port 220 onto disperse chamber 211 inside.So also will being discharged to, upper part disperses outside the chamber.This illustrates at Fig. 9 and 10.In fact, in

window

255 and 275 aspectant these positions, user is tilting gearing and pass described window and discharge one or more bladder parts simply.Advantageously, for impel user in primary importance, namely be next bladder of packing in the position of opening disperseing the chamber, main body 210 has a window 219 and valve component 250 has indicateing arm 259, for example word EJECT(discharges), when two

windows

255 and 275 when being face-to-face, this indicateing arm will be presented in the described window 219.When needed, in the second end position, namely in the position that bladder has been opened, word INHALE(sucks) or similar word can be displayed in the window 219 with the indication user its in the position that can suck.Also can some witness markings be set at the second retained part 260 and/or main body 210, to indicate intuitively described the second retained part of user with respect to two end positions of described main body.

Therefore, this embodiment of the present invention can be realized such device: the operator does not need to operate the termination, oral cavity to use this device.In addition, he also no longer need to be after each the use stripping device to discharge or to get rid of empty bladder part.Therefore, the risk of missing of the risk that infects and pollute and the components that is disassembled or the risk that after taking apart, no longer can ressemble in addition device have greatly been limited.This embodiment is simple especially, because it only has three parts.This embodiment can guarantee the fine dispersion of powder, and this is because in the bladder part of disperseing chamber mesoscale eddies motion, powder is not coalescent in suitable mode on the one hand, but also owing to is placed in the input of the additional air in main body 210 and/or the axis of centres 261.The using method of device is also very simple, and user is as long as mobile the second retained part is with actuating device fully between two end positions of the second retained part.Therefore, user at first inserts bladder, and then user rotates the second retained part towards the second end position of the second retained part, and user sucks, and user makes the second retained part return towards the first end position of the second retained part.

For those skilled in the art, various modifications also are possible, do not exceed the scope of the present invention of determining as by appended claims.Various features and the function of the device that describes with reference to the accompanying drawings especially, can make up each other in any suitable manner.

Claims

1. dry powder inhaler, it has the main body (210) of basic cylindricality, described main body (210) has the termination, oral cavity (230) of definition dispensing orifice (231) on the one hand on its cylindricality wall body, has on the other hand the loading port (220) that holds the bladder (10) of a dosage dry powder for reception, described main body (210) partly locates to be equipped with first retained part (270) fixing with respect to described main body at its first axial end portion, and partly locate to be equipped with in rotation between two end positions at its second axial end portion and be installed on the second retained part (260) on the described main body, described the second retained part (260) has the axis of centres (261), the described axis of centres supports a projection (265), at described the second retained part (260) between two end position during rotary moving, described projection is suitable for opening the bladder (10) that is inserted in the described loading port (220), it is characterized in that, described the first retained part have be provided with window (275) axially close wall body (271), the described axis of centres (261) supports a valve component (250), described valve component forms closing component and is connected with described the second retained part aspect rotation, described valve component has an axial wall (251) that is provided with window (255), the window of described axial wall cooperates with the wall body (271) of axially closing of described the first retained part, so that in an end position of described the second retained part (260), described window (255,275) alignment is to open described dispersion chamber (211), and in another end position of described the second retained part (260), described window staggers each other angularly, so that described dispersion chamber is closed.

2. dry powder inhaler as claimed in claim 1, it is characterized in that, described main body (210) has opening (219), and described valve component (250) has by the visible suitable indicateing arm of described opening (219) (259), is used to indicate in one or the other described end position that the described dry powder inhaler of user is in described the second retained part (260).

3. dry powder inhaler as claimed in claim 1 or 2, it is characterized in that, described main body (210) and/or described the second retained part (260) have suitable labelling, are used to indicate in one or the other described end position that the described dry powder inhaler of user is in described the second retained part (260).

4. such as each described dry powder inhaler in the above-mentioned claim, it is characterized in that described dispersion chamber (211) has around the shape of the basic annular of the described axis of centres (261).

5. such as each described dry powder inhaler in the above-mentioned claim, it is characterized in that, described dispersion chamber (211) and/or the hollow described axis of centres (261) have the inlet port (218,269) of air, the inlet port of described air allows to produce when sucking and replenishes air flow, so that powder carried out eddying motion more at described dispersion intracavity before being inhaled into.

6. dry powder inhaler as claimed in claim 5 is characterized in that, the inlet port of described air (218) is implemented in the cylindricality wall body of described main body (210) in tangential mode.

7. such as claim 5 or 6 described dry powder inhalers, it is characterized in that the described axis of centres (261) is hollow, and in described dispersion chamber (211), especially locate to have at least one opening (269) near described projection (265).

8. such as each described dry powder inhaler in the above-mentioned claim, it is characterized in that termination, described oral cavity (230) is equipped with aperture plate (237), discharge in order to stop bladder partly to pass described dispensing orifice (230).