CN103040849A - Tannic acid preparation for treating burn, bedsore and diaper dermatitis and preparation method thereof - Google Patents

Abstract

The invention relates to a tannic acid preparation and a preparation method, and the tannic acid preparation is characterized by comprising, by weight, 2-30% of tannic acid, 40-75% of pharmaceutical adjuvants, and 20-50% of water. The pharmaceutical adjuvants used in the preparation comprise glycerin, monoglyceride stearate, beeswax, Vaseline, paraffin, tween, span, sodium bisulfate, ethylparaben, etc. The preparation method comprises the following steps: dissolving tannic acid by a little water or ethanol, heating to 55-85 DEG C to prepare an oil phase and a water phase, finally adding the water phase into the oil phase under uniform stirring, and performing condensation and split charging to obtain the tannic acid preparation. The preparation comprises paste agents (ointment, plaster), cream, emulsion, oil agents, water aqua, and the like, and the tannic acid content can be determined by a spectrophotometric method. The prepared tannic acid preparation conforms with medicine standards, and is suitable for the treatment of burn, bedsore and diaper dermatitis (neonatal red buttock) and the like.

Description

A kind of tannic acid preparation and preparation method for the treatment of burn, decubital ulcer and diaper dermatitis

Technical field

The present invention relates to a kind of tannic acid preparation and preparation method, meet drug standard, be mainly used in treating the diseases such as burn, decubital ulcer, diaper dermatitis, belong to biomedicine field.

Background technology

Tannic acid (Gallotannin, Tannin), have another name called tannic acid, tannin, tannin, two gallic acids, larch extract, gallotannic acid, tannin, charcoal Buddhist nun acid, gentle acid, molecular weight is 1701.20, and fusing point is 210～215 ℃, little have a special odor, the astringent taste that tool is strong reveals that to put in light and the air complexion changed dark, water-soluble, easy molten ethanol, acetone and glycerol are dissolved in ether, benzene, chloroform and petroleum ether hardly.Tannic acid energy precipitating proteins, all can form insoluble complex with alkaloid, glycoside and heavy metal etc., the Chang Zuowei astringent, the local use not only treated the diseases such as exudative ulcer, scald, decubital ulcer, hemorrhoid, eczema, stomatitis, tonsillitis, pharyngolaryngitis, and with its solution gastric lavage the poisonings such as year of Apomorphinum, scholar, Folium Digitalis Purpureae, lead, silver, copper, zinc had Detoxication.

Because tannic acid is water-disintegrable tannin; the a large amount of use is absorbed into meeting infringement liver in the body; therefore tannic acid often is made into external preparation for clinical; such as tannic acid ointment energy precipitating proteins; astriction is arranged; make the skin hardening; thereby protection mucosa; prevent undue secretion and hemostasis; and can reduce local pain, the blood plasma that reduces injury oozes out, and prevents the effect that antibacterial infects; can be used for the treatment burn; eczema; decubital ulcer and diaper dermatitis (neonate diaper dermatitis); it is uneven that but the tannic acid ointment that previous methods is made often exists tannic acid to disperse, and granule is thicker, easy oxidation discoloration; the substrate layering easily occurs in the storage process; usually smear inequality during clinical use, lowered effective contact area of tannic acid and skin, directly affect the effect of medicine.

Summary of the invention

The tannic acid preparation of the present invention's preparation belongs to weak water-in-oil type preparation, and containing by weight tannic acid is 2 ~ 30%, pharmaceutic adjuvant 40 ~ 75% and water 20 ~ 50%, outward appearance such as emulsifiable paste shape, feel is fine and smooth, meets medicinal standard, is mainly used in treating the diseases such as burn, decubital ulcer, diaper dermatitis.

The tannic acid preparation of the present invention's preparation comprises unguentum (ointment, plaster), cream, Emulsion, oil preparation, water preparation, contain principal agent tannic acid (being 2 ~ 30% by weight), a certain proportion of pharmaceutic adjuvant comprises that glyceryl monostearate, Cera Flava, vaseline, paraffin etc. are main ingredient, glycerol etc. are wetting agent, tween, span etc. are emulsifying agent and surfactant, sodium sulfitees etc. are antioxidant, and ethyl hydroxybenzoate etc. are antiseptic (being 40 ~ 45% by weight) and suitable quantity of water (water is 20 ~ 50% by weight).

Tannic acid formulation preparation method of the present invention comprises the steps:

With a small amount of water or dissolve with ethanol tannic acid, add the glycerol mixing, obtain glycerinum acidi tannici solution;

Glyceryl monostearate, Cera Flava, vaseline, paraffin, tween etc. are heated to 55 ~ 85 ℃, and stirring obtains oil phase;

Glycerinum acidi tannici solution, this dish, water, antiseptic etc. are heated to 55 ~ 85 ℃, and stirring obtains water;

Being heated in 55 ~ 85 ℃ of situations, water is joined in the oil phase, the limit edged stirs, and the condensation packing gets the tannic acid preparation.

The tannic acid preparation major advantage of the present invention's preparation is to adopt ethanol or water dissolution tannic acid, adds emulsifying agent, surfactant and wetting agent, and the emulsifying degree is high, non-oxidizability is strong, good stability has guaranteed product quality so that this tannic acid preparation evenly, fine and smooth, without granular sensation.The tannic acid preparation advantage of the present invention's preparation is easy to smear evenly when being clinical use, effectively increase the contact area of tannic acid and skin, directly promote drug effect, when but this tannic acid preparation shortcoming is large-area applications, because wound surface is easy to absorb, liver there is violent toxicity, cause hepatic necrosis when serious, and the intensification wound surface, so delayed healing is unsuitable large tracts of land or life-time service.

The tannic acid preparation tannic acid qualitative reaction of the present invention preparation: get this tannic acid preparation a little, it is an amount of to add purified water, boils, lets cool, filters, and gets filtrate 1ml and adds 2 of liquor ferri trichloridis, namely aobvious black-and-blue, adds sulphuric acid again, presents yellow mercury oxide again.

The tannic acid preparation tannic acid quantitative testing of the present invention's preparation:

It is an amount of that precision takes by weighing the tannic acid reference substance, and water is mixed with every milliliter of reference substance solution that contains 0.01mg; Precision take by weighing the present invention preparation the tannic acid preparation a little, add 70 ~ 80 ℃ of hot water and dispose suitable solution, and use a small amount of decolorizing with activated carbon, filter discard at the beginning of filtrate, get again subsequent filtrate and dispose suitable solution; Use spectrophotography, measure the solution absorption degree at the wavelength place of 276nm, calculate tannic acid content.

Linear relationship, repeatability and the response rate of tannic acid content are good in this spectrophotometry sample, are fit to the tannic acid preparation tannic acid quantitative testing of the present invention's preparation.

The tannic acid preparation preparation process of the present invention's preparation is used medicinal raw material and pharmaceutic adjuvant, produce according to the pharmaceutical production working specification, meet drug standard fully, namely meet " the Drug Administration Law of People's Republic of China ", " medicine registration management way " and " second regulation of Chinese pharmacopoeia.

With Canis familiaris L., rabbit, Cavia porcellus, rat and mice (particularly new born animal) research experiment, the tannic acid preparation of the present invention's preparation can promote skin burn, skin ulcer, soda acid to cause the incrustation healings such as scytitis, the blood plasma that reduces injury oozes out, and prevents bacterial growth.Through clinical life-time service, the disease effects such as tannic acid preparation for treating burn, eczema, decubital ulcer and diaper dermatitis (neonate diaper dermatitis) of the present invention's preparation are good.

The specific embodiment

1. tannic acid ointment is write out a prescription:

Raw material	Recipe quantity
		Tannic acid	50g
Glycerol	50g
		Sodium sulfite	1g
Glyceryl monostearate	120g
		Cera Flava	50g
Paraffin	50g
		Yellow Vaselin	50g
Liquid paraffin	250g
		Sorbester p17	20g
Tween 80	10g
		Ethyl hydroxybenzoate	2g
Water	Add to 1000g

2. tannic acid ointment preparation:

First with tannic acid with a small amount of ethanol or water dissolution, then with the glycerol mixing, get glycerinum acidi tannici solution.Glyceryl monostearate, Cera Flava, paraffin, Yellow Vaselin, liquid paraffin and sorbester p17 are heated to 70 ℃, and stirring obtains oil phase.Glycerinum acidi tannici solution, Tween 80, ethyl hydroxybenzoate and water are heated to 70 ℃, and stirring obtains water.Water is joined in the oil phase, and the limit edged stirs, and the condensation packing gets tannic acid ointment.

3. tannic acid check:

Qualitative reaction: get the about 1g of this tannic acid preparation, add purified water 5ml, boil, let cool, filter, get filtrate 1ml and add 2 of liquor ferri trichloridis, namely aobvious black-and-blue, add again sulphuric acid, present yellow mercury oxide again.

Quantitative testing: precision takes by weighing tannic acid reference substance 50.0mg, puts in the 100ml measuring bottle, and water is mixed with every milliliter of storing solution that contains 0.5mg; The accurate storing solution 2ml that draws puts in the 100ml measuring bottle, adds water and puts scale, shakes up, and water is mixed with every milliliter of reference substance solution that contains 0.01mg; Precision takes by weighing this tannic acid ointment 1.0g, adds 70 ℃ of hot water 20ml, after stirring makes it to dissolve, change the 100ml measuring bottle over to, add again water approximately to 80ml, put up and down constantly jolting of hot bath, make the tannic acid dissolving, and cooling solidifies substrate, place room temperature after, add water to scale, shake up, use a small amount of decolorizing with activated carbon, filter and discard just filtrate, get again subsequent filtrate and dispose suitable solution; Use spectrophotography, measure the solution absorption degree at the wavelength place of 276nm, calculate tannic acid content with reference substance.

4. this tannic acid ointment purposes:

This tannic acid ointment meets medicinal standard, is mainly used in treating the diseases such as burn, decubital ulcer, diaper dermatitis (neonate diaper dermatitis).

Claims (10)

1. tannic acid preparation, it is characterized in that containing by weight tannic acid is 2 ~ 30%, pharmaceutic adjuvant 40 ~ 75% and water 20 ~ 50%.

2. pharmaceutic adjuvant claimed in claim 1, its feature comprises glycerol, glyceryl monostearate, Cera Flava, vaseline, paraffin.

3. pharmaceutic adjuvant claimed in claim 1, its feature also comprises tween, span emulsifying agent.

4. preparation claimed in claim 1, its feature also contains sodium sulfite, ethyl hydroxybenzoate, benzoic acid antiseptic.

5. preparation claimed in claim 1, its preparation method comprises the steps:

With a small amount of water or dissolve with ethanol tannic acid, add the glycerol mixing, obtain glycerinum acidi tannici solution;

Glyceryl monostearate, Cera Flava, vaseline, paraffin, tween are heated to 55 ~ 85 ℃, and stirring obtains oil phase;

Glycerinum acidi tannici solution, span, water, antiseptic are heated to 55 ~ 85 ℃, and stirring obtains water;

Being heated in 55 ~ 85 ℃ of situations, water is joined in the oil phase, the limit edged stirs, and the condensation packing gets the tannic acid preparation.

6. the described preparation of claim 5, its feature comprises unguentum, cream, Emulsion, oil preparation, water preparation.

7. the described preparation of claim 6 is characterized in that unguentum comprises ointment, plaster.

8. tannic acid preparation claimed in claim 5 is characterized in that adopting spectrophotometry tannic acid content.

9. preparation claimed in claim 6, its feature meets drug standard.

10. preparation claimed in claim 9 is characterized in that being applicable to burn, decubital ulcer, diaper dermatitis treatment.