CN102246794A - Composition for killing microbes - Google Patents
Composition for killing microbes Download PDFInfo
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- CN102246794A CN102246794A CN2011101513415A CN201110151341A CN102246794A CN 102246794 A CN102246794 A CN 102246794A CN 2011101513415 A CN2011101513415 A CN 2011101513415A CN 201110151341 A CN201110151341 A CN 201110151341A CN 102246794 A CN102246794 A CN 102246794A
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Abstract
The invention relates to a composition for killing microbes, which is mainly used for hand antisepsis, surgical hand antisepsis and antisepsis of skins and mucosa and can be also used for killing the microbes at the surfaces of the articles; polyhexamthylene guanidine hydrochloride and ethanol are adopted as main active fungicide ingredients to be combined with a fungicide synergistic agent isopropanol, wherein the concentration of the ethanol is 79-467 g/L, the concentration of the polyhexamthylene guanidine hydrochloride is 0.01-15 g/L and the concentration of the isopropanol is 3-54 g/L; meanwhile, a moisturizer, a stabilizing agent, a thickening agent and other agents can be added as needed to obtain different dosage forms; and the composition has the advantages of good fungicide effect, high speed, no washing, high stability, reduction of skin irritation of the product and functions of protecting and moisturizing skins.
Description
Technical field
The present invention relates to be used for hand, skin, mucous membrane, and the composition can be disposable, efficient killing microorganisms that comprises the article surface of eating kitchenware.
Background technology
Because increasing the weight of of global warming and environmental pollution, the variation of pathogenic microorganisms is accelerated; The abuse of various antibiotic, antiviral drugs; virus to antibiotic and the immunity of enantiopathy cytotoxic drug; and the generation of the pathogenic microorganisms of highly pathogenic highly infective is also being accelerated; breaking out of the infectious disease that reply and control are caused by pathogenic microorganisms with popular; just must control source of infection, cut off route of transmission and protection Susceptible population; wherein, cutting off the route of transmission is safe and reliable important means.
Different with traditional antimicrobial products, disposable product has overcome following difficulty: not limited by the water source, can use whenever and wherever possible; Employed material can not damage skin and article; Employed material can not cause the appearance of anti-medicine microorganism as much as possible, that is to say that antifungal medicament, antiviral drug etc. can not appear in washing-free antibacterial, the sterile products.The material of traditional removing pathogenic microorganisms, because of its exist skin irritatin, allergy, bactericidal effect poor, stain reasons such as skin, bleaching article, can't be used for disposable sterilization, as phenols, high concentration alcohols, heavy metal salt, surfactant, quaternary ammonium compound, oxide (comprising peroxide, hydrogen peroxide, bleaching water or the like), halogen-containing material (as Iodophor etc.) and destroy small molecule aldehyde compound of DNA and RNA or the like.
Methylguanidine in poly hexamethylene biguanide (PHMB) compound has very high activity, easily by bacterium, viral adsorbed, directly act on microorganism, the division copy function that has suppressed bacterium, virus, the respiration channel of microorganism has been stopped up in its formation at microorganism body surface polymer, and microorganism is choked to death.Simultaneously, its high molecular polymer structure is improved the effective active of guanidine radicals, and bacterium is difficult for producing drug resistance.
This compound draws the systematic toxicology conclusion of poly hexamethylene biguanide: 1. low acute toxicity at last in the systematic Study of research, reviviscence toxicity research and the metabolism of the research of European medicine industry by studies on acute toxicity, human body toxicological study, Study on Subchronic, chronic toxicity and the carcinogenic possibility of system, genotoxicity; 2. when at normal using dosage, have low skin and eye irritation; 3. low long-term toxicity; 4. there is not genotoxicity; 5. non-teratogenesis; 6. by the no reviviscence toxicity that studies have shown that between two generations; 7. at the mankind, belong to the non-carcinogenic potential drug.
The bactericidal mechanism of ethanol mainly is by removing the lipid in the mycoderm that degerms, make the sex change of bacterium bacterium protein solidify performance sterilization or bacteriostasis, being widely used in the sterilization field.With the poly hexamethylene biguanide compatibility, can produce synergy, improve the sterilization biologically active.Add isopropyl alcohol simultaneously, good fit with above-mentioned system, produce better bactericidal activity.The volatility of ethanol and isopropyl alcohol is extremely strong, and product is dry and comfortable rapidly after using.
At present, Chinese patent literature discloses many disposable quick sterile products that can be used for hand, skin, mucous membrane and article surface, and wherein part has selected for use alcohols, polymerization guanidine class etc. to be bactericidal active ingredient.
Application number is 200910114010.7 patent application document, disclosing a kind of is that main bactericidal active ingredient, polyoxyethylene nonylphenol ether are the skin degerming product of surfactant by polyhexamethylene hydrochloric acid biguanides and ethanol, its ethanol percentage by weight 50% ~ 60%, polyhexamethylene hydrochloric acid biguanides 0.52% ~ 0.63%; Application number is 200980108019.5 Chinese patent, a kind of pure antimicrobial skin health composition that comprises the cationic-compatible thickener is disclosed, it comprises alcohol at least about 60%, thickened systems, cationic compound (as poly hexamethylene biguanide) etc., and its concentration is higher.
Application number is 200680032102.5 Chinese patent application file, disclose a kind of by poly hexamethylene biguanide, less important antimicrobial, and the antimicrobial compositions of optional organic acid, processing auxiliary agent such as pure and mild surfactant composition, it realized about 3 log in 30 minutes
10The killing effect of reduction, or at least 1 log in 5 ~ 10 minutes time
10The minimizing of microorganism.
Application number is the Chinese patent application file of 03139745.x, a kind of sterile products of being made up of 95% ethanol 35% ~ 60%, poly hexamethylene biguanide 0.5% ~ 1.0%, flavouring agent 0.01 ~ 0.5%, water surplus is disclosed, it is used for skin degerming, does not add any composition of preserving moisture.
Application number is 200910114009.4 Chinese patent application file, a kind of prescription of liquid disinfectant is disclosed, with polyamine propyl group biguanides (claiming poly hexamethylene biguanide again) is main active ingredient, selecting polyoxyethylene nonylphenol ether for use is surfactant, adding essence makes, this disinfectant acts on 15min to Escherichia coli, on average kills logarithm value＞5.00; To Candida albicans effect 15min, on average kill logarithm value＞3.51.
Foregoing invention perhaps contains a large amount of alcohols materials, is used for the sterilization of hand, skin for a long time, may cause skin dry lack of water, rubescent, chap, and to the transportation of sterile products, store and propose higher requirement; Or bactericidal effect is general, needs the long period just can reach or can't reach at all and the quick kill bacteria of present composition equivalence and the ability of virus; Or formula components is on the high side, preparation process is loaded down with trivial details, complex process.
Summary of the invention
The objective of the invention is to: a kind of composition of killing microorganisms is provided, is used for the antibiotic and sterilizing of hand, skin, mucous membrane and comprises killing of the article surface microorganism that eats kitchenware.Have bactericidal effect good, can be disposable, advantage that stability is high, can be widely used in occasions such as daily life, tourism trip, hotel, hotel, hospital, kindergarten, public transport, pet sterilization.
The invention provides the composition of the quick killing microorganisms of a kind of energy, overcome the deficiencies in the prior art, it is simple to have raw material, and production cost is low, the simple advantage of preparation technology; Under the prerequisite that guarantees the efficient sterilizing effect, preferred bactericidal active ingredient than low dosage, total alcohol amount declines to a great extent, and transportation stores convenient; According to the needs of purposes and formulation, add humectant, thickener etc. simultaneously, slow down stimulation, the skin moisten skin care of product, make sterile products, thereby prolong the lasting bacteriostasis of sterile products in skin and article surface film forming to skin.
Technical scheme of the present invention:
A kind of composition of killing microorganisms comprises each component and concentration thereof and is in the composition:
| Ethanol | 79~467 g/L |
| Poly hexamethylene biguanide or its salt | 0.01~15 g/L |
| Isopropyl alcohol | 3~54 g/L |
| Water | Surplus |
The bactericidal active constituent concentration of ethanol is preferably 238 ~ 447 g/L in the above-mentioned composition, 379 ~ 427 g/L more preferably,
406 g/L most preferably; The concentration of hexamethylene is preferably 0.1 ~ 10g/L, more preferably 2 ~ 4 g/L, most preferably 3 g/L; Preferred 27 ~ 51 g/L of the concentration of sterilization synergist isopropyl alcohol, more preferably 33 ~ 45 g/L, most preferably 39 g/L.According to formulation and purposes needs, can also add any or its combination in humectant or stabilizing agent or thickener or the odor mask in the composition.
Above-mentioned composition can or apply/be adsorbed in form on the base material as required with liquid preparation, spray, is used for the antibiotic and sterilizing of hand, skin, mucous membrane, and comprises killing of the article surface microorganism that eats kitchenware.
Apply/be adsorbed in the form on the base material, include but are not limited to as wet sanitary napkins, wet wiping towel, hand and wipe the annex solution that towel, face are wiped towel.
If be used for hand, skin antibiotic and sterilizing, can add skin conditioner such as humectant or stabilizing agent or an amount of thickener etc. in the composition.Add skin conditioner in hand, the skin antiseptic, can not only reduce the stimulation of disinfectant, also can prolong drying time, make disinfectant be easy to smear, strengthen antibacterial effect skin.
If be used for the article surface sterilization, can add thickener, stabilizing agent etc. in the composition.
According to special requirement, can add an amount of odor mask in the composition, as essence, single-propylene glycol.
Humectant includes but not limited to described in the composition: one or more any combinations in polyalcohol such as glycerine or propane diols, polyethylene glycol, pyrrolidone sodium carboxylate, amide-type humectant, mucopolysaccharides, panthenol, jojoba oil, natural plant extracts, hyaluronic acid, double hyaluronic acid, ceramide, silk-fibroin/silk peptide class humectant, collagen, glucosan derivative, chitin shitosan and derivative thereof, 1-alkyl glycerol ether compound, the ethoxy phosphoamide.
Stabilizing agent described in the composition comprises but is not limited to bronopol, acid-base modifier.
Thickener described in the composition includes but not limited to hydroxyethylcellulose, hydroxypropyl cellulose, HPMC, polyethylene glycol, the compound based on polyethylene glycol, polyacrylamide, polyacrylamide methyl propane sulfonic acid, butylation PVP, polyglycereol-10 behenates/eicosane diacid ester, acrylate copolymer, based on one or more any combinations in the polymer of acrylate.
The present invention adopts ethanol and poly hexamethylene biguanide or its salt as fungicide active ingredient, and adding isopropyl alcohol simultaneously is the sterilization synergist, and advantage is:
1, raw material are simple and easy to, and production cost is low, preparation technology is simple;
2, solve tradition and contained the problem that total alcohol amount in the pure sterile products highly causes transporting, storage cost significantly increases;
3, it is low to contain alcohol amount, simultaneously, adds the composition of preserving moisture when composition of the present invention is used for skin degerming, thereby has overcome dry skin lack of water, rubescent, the crack that traditional sterile products causes;
4, bactericidal effect is good, and preferred prescription also has the stronger ability of killing to AIDS virus etc., is applicable to all kinds of personnel hands, skin, antibiotic, the sterilization of mucous membrane, and the killing of microorganism that comprises the article surface of eating kitchenware;
5, can be used for disposable formulation product.
Embodiment
Further specify technical solution of the present invention below in conjunction with specific embodiment, these embodiment can not be interpreted as it is restriction to technical solution.
Embodiment 1
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol (volume ratio down successively, being converted into mass ratio is 92.3%, 440kg, isopropyl alcohol 39kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down together), finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
Wherein, glycerine has the effect of skin moisten skin care, can slow down the stimulation of alcohols solvent to skin; HPMC can make this thimerosal in skin and article surface film forming, prolongs the antibacterial time; Bronopol is used used as stabilizers in this product.
In the composite formula, the mass percent that is equivalent to bactericidal active constituent ethanol is 45.6%; The mass percent of hexamethylene is 0.33%; The mass percent of isopropyl alcohol is 4.3%.
After testing, under 20 ℃ ± 1 ℃ condition, composition stoste effect 1.0 min, Escherichia coli are on average killed logarithm value＞5.00, staphylococcus aureus is on average killed logarithm value＞5.00, pseudomonas aeruginosa is on average killed logarithm value＞5.00, Candida albicans is on average killed logarithm value＞4.00, to influenza virus on average kill logarithm value＞4.00, stability meets the requirement of Ministry of Health of the People's Republic of China's " disinfection technology standard " (version in 2002), the term of validity 24 months.
Through check, to chmice acute per os LD
50＞5000 mg/kg body weight, true border is nontoxic; Repeatedly intact skin irritant test total mark mean value is 0, skin irritation index＜0.5, and stimulus intensity belongs to nonirritant; PCEMNR there is not the micronucleus of causing effect; It is 1000 mg/kg body weight that maximum is not observed illeffects dosage.
Embodiment 2
The preparation method of this sanitizing composition is adsorbed in the thimerosal for preparing in the nonwoven as the wet tissue annex solution with example 1, makes wet sanitary napkins.
After testing, under 20 ℃ ± 1 ℃ condition, wet sanitary napkins effect 1 min, colibacillary average kill ratio is 100%, the average kill ratio of staphylococcus aureus is 100%, the average kill ratio of pseudomonas aeruginosa is 100%, average kill ratio to hemolytic streptococcus is 99.94%, to the oidiomycetic average kill ratio of white is 99.91%, to influenza virus on average kill logarithm value＞3.00, to deactivation logarithm value＞3.00 of HIV virus.
Hand sterilization field trial: through 30 person-times of repeated tests, wet sanitary napkins effect 1min on average kills logarithm value＞1.00 to the natural bacteria on hand surface.
Escherichia coli simulated field sterilizing test: prove through 30 sampling tests, pollute colibacillary body surface 1min with the wet sanitary napkins wiping, the Escherichia coli average kill ratio that body surface is polluted is 100%.
Keep in relative moisture under 〉=75% the condition, place 14 days (being equivalent to room temperature placed 1 year) in 54 ℃ of insulating boxs after, wet sanitary napkins effect 1min still is 100% to colibacillary average kill ratio.
Embodiment 3
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, 95% ethanol 258kg, isopropyl alcohol 9kg, glycerine 12kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 4
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1.5kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.5kg, the 20% hexamethylene aqueous solution, 13.5 kg, 95% ethanol, 414 kg, isopropyl alcohol 27kg, glycerine 5kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 5
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.3kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.2kg, 20% hexamethylene aqueous solution 16.5kg, 95% ethanol 465kg, isopropyl alcohol 45kg, glycerine 8kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 6
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.6kg, the 20% hexamethylene aqueous solution, 22.5 kg, 95% ethanol 440kg, isopropyl alcohol 54kg, glycerine 4kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 7
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.2kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.7kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol, 258 kg, isopropyl alcohol 54 kg, glycerine 15kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 8
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.8kg, the 20% hexamethylene aqueous solution, 15 kg, 95% ethanol, 258 kg, isopropyl alcohol 45 kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 9
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.7kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.9kg, the 20% hexamethylene aqueous solution, 14.5 kg, 95% ethanol, 430 kg, isopropyl alcohol 38 kg, glycerine 6kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 10
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1.2kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 1.2kg, the 20% hexamethylene aqueous solution, 14 kg, 95% ethanol, 420 kg, isopropyl alcohol 37 kg, glycerine 7kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 11
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 1.3kg, the 20% hexamethylene aqueous solution, 15.5 kg, 95% ethanol, 450 kg, isopropyl alcohol 40 kg, glycerine 4kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 12
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 2kg, the 20% hexamethylene aqueous solution, 16 kg, 95% ethanol, 460 kg, isopropyl alcohol 41 kg, glycerine 8kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 13
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add bronopol 0.5kg, 20% hexamethylene aqueous solution 12kg, 95% ethanol 480kg, isopropyl alcohol 51kg, glycerine 10kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 14
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 435kg, isopropyl alcohol 38 kg, glycerine 5kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 15
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add 20% hexamethylene aqueous solution 11kg, 95% ethanol 400kg, isopropyl alcohol 30kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 16
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add 20% hexamethylene aqueous solution 5kg, 95% ethanol 506kg, isopropyl alcohol 9kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 17
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add 20% hexamethylene aqueous solution 13.5kg, 95% ethanol 465kg, isopropyl alcohol 27kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 18
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add 20% hexamethylene aqueous solution 16.5kg, 95% ethanol 414kg, isopropyl alcohol 45kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 19
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add 20% hexamethylene aqueous solution 22.5kg, 95% ethanol 258kg, isopropyl alcohol 54kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 20
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add the 20% hexamethylene aqueous solution, 14.5 kg, 95% ethanol, 450 kg, isopropyl alcohol 38kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 21
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add the 20% hexamethylene aqueous solution, 14 kg, 95% ethanol, 460 kg, isopropyl alcohol 37 kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 22
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add the 20% hexamethylene aqueous solution, 15.5 kg, 95% ethanol, 430 kg, isopropyl alcohol 40 kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 23
According to the following steps preparing product: in preparing tank, add the 200L purified water, stir and add the 20% hexamethylene aqueous solution, 16 kg, 95% ethanol, 420 kg, isopropyl alcohol 41 kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 24
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.2kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 410kg, isopropyl alcohol 52kg, glycerine 8kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 25
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.9kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.27kg, 20% hexamethylene aqueous solution 40kg, 95% ethanol 506kg, isopropyl alcohol 15kg, glycerine 9kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 26
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1.1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.33kg, 20% hexamethylene aqueous solution 30kg, 95% ethanol 435kg, isopropyl alcohol 20kg, glycerine 11kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 27
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1.5kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.4kg, 20% hexamethylene aqueous solution 25kg, 95% ethanol 430kg, isopropyl alcohol 32kg, glycerine 12kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 28
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 360kg, isopropyl alcohol 36kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 29
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, the 20% hexamethylene aqueous solution, 19 kg, 95% ethanol, 310 kg, isopropyl alcohol 42 kg, glycerine 5kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 30
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.2kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, the 20% hexamethylene aqueous solution, 17 kg, 95% ethanol, 500 kg, isopropyl alcohol 43 kg, glycerine 1 kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 31
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 18kg, 95% ethanol 490kg, isopropyl alcohol 44kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 32
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add 20% hexamethylene aqueous solution 3kg, 95% ethanol 290kg, isopropyl alcohol 47kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 33
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into C10-30 alkylol acrylamide acid esters cross-linked polymer (acrylate copolymer a kind of) 2kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 7kg, 95% ethanol 160kg, isopropyl alcohol 49kg, glycerine 10 kg, alkylol acrylamide acid esters cross-linked polymer solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 34
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, ethylhexyl glycerine (a kind of 1-alkyl glycerol ether compound) 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 35
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into polyglycereol-10 behenates/eicosane diacid ester 50kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, ethylhexyl glycerine (a kind of 1-alkyl glycerol ether compound) 10kg, ethohexadiol 3kg, polyglycereol-10 behenates/eicosane diacid ester solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 36
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, ethoxy phosphoamide 50 kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 37
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, PPG-20 methyl glucose ether (a kind of glucosan derivative) 50 kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 38
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, extract solution from aloe 1 kg, glycerine 2 kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 39
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, jojoba oil 0.5 kg, marine algae extract 2 kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 40
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, hyaluronic acid 5 kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 41
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, shitosan 10 kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 42
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, ceramide 1 kg, glycerine 2kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 43
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, silk peptide 5 kg, glycerine 5 kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 44
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 45
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, 95% ethanol 258kg, isopropyl alcohol 9kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 46
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, the 20% hexamethylene aqueous solution, 13.5 kg, 95% ethanol, 414 kg, isopropyl alcohol 27kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 47
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 16.5kg, 95% ethanol 465kg, isopropyl alcohol 45kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 48
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, the 20% hexamethylene aqueous solution, 22.5 kg, 95% ethanol 440kg, isopropyl alcohol 54kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 49
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol, 258 kg, isopropyl alcohol 54 kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 50
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, the 20% hexamethylene aqueous solution, 15 kg, 95% ethanol, 258 kg, isopropyl alcohol 45 kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 51
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 52
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 5kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 53
Prepare spray according to following steps: in preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 54
Prepare spray according to following steps: in preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 5kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 55
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into hydroxyethylcellulose 200kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, pyrrolidone sodium carboxylate 50kg, hydroxy ethyl fiber cellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
Embodiment 56
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into hydroxyethylcellulose 150kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg, hydroxy ethyl fiber cellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
Embodiment 57
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into hydroxyethylcellulose 100kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 13kg, 95% ethanol 462kg, isopropyl alcohol 35kg, glycerine 15kg, hydroxy ethyl fiber cellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
Embodiment 58
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into hydroxypropyl cellulose 180kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 15kg, hydroxypropyl cellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
Embodiment 59
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into polyethylene glycol 190kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 1 kg, polyglycol solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
Embodiment 60
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into polyethylene glycol 190kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 1 kg, an amount of, the polyglycol solution of essence down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
Embodiment 61
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 334kg, isopropyl alcohol 51 kg, glycerine 5 kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 62
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 463kg, isopropyl alcohol 33 kg, glycerine 5 kg, single-propylene glycol 50kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 63
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1 kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 484kg, isopropyl alcohol 41 kg, glycerine 3 kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
The product for preparing also can be used as the wet tissue annex solution and is adsorbed in the nonwoven, makes wet tissue.
Embodiment 64
According to the following steps preparing product: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.In preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 411kg, isopropyl alcohol 34kg, glycerine 5kg, Hydroxypropyl methylcellulose solution down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, qualified back packing.
Embodiment 65
Prepare spray according to following steps: in preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 75kg, 95% ethanol 86kg, isopropyl alcohol 54kg, glycerine 5kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 66
Prepare spray according to following steps: in preparing tank, add the 200L purified water, stir and add bronopol 0.5kg, 20% hexamethylene aqueous solution 50kg, 95% ethanol 258kg, isopropyl alcohol 54kg, glycerine 10kg down successively, essence is an amount of, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 67
Prepare spray according to following steps: in preparing tank, add the 200L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 386kg, isopropyl alcohol 3kg, glycerine 5kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 68
Prepare spray according to following steps: in preparing tank, add the 200L purified water, stir and add bronopol 0.5kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 440kg, isopropyl alcohol 6kg, double hyaluronic acid 2kg, glycerine 5kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 69
Prepare spray according to following steps: in preparing tank, add the 200L purified water, stir and add bronopol 0.5kg, 20% hexamethylene aqueous solution 0.5kg, 95% ethanol 400kg, isopropyl alcohol 39kg, glycerine 9kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 70
Prepare spray according to following steps: in preparing tank, add the 200L purified water, stir and add bronopol 0.5kg, 20% hexamethylene aqueous solution 0.05kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg down successively, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 71
Prepare spray according to following steps: in preparing tank, add the 200L purified water, stir and add bronopol 0.5kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg down successively, single-propylene glycol 50kg, finish to stir and stop after 5 ~ 10 minutes stirring, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Embodiment 72
According to the following steps preparing product: in stainless steel cask, add the 50L purified water, stir and add bronopol 0.3kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 400kg, isopropyl alcohol 39kg, butylation PVP350Kg down successively, finish and stir to clarify, add purified water to the 1000L scale, continue to stir 15 minutes.Check, be sub-packed in after qualified in the spray bottle of band hand pump.
Claims (7)
1. the composition of a killing microorganisms, it is characterized in that: comprising each component and concentration thereof in the composition is
。
2. composition according to claim 1 is characterized in that: comprising each component and concentration thereof in the composition is
。
3. composition according to claim 2 is characterized in that: comprising each component and concentration thereof in the composition is
。
4. composition according to claim 3 is characterized in that: comprising each component and concentration thereof in the composition is
。
5. according to the arbitrary described composition of claim 1-4, it is characterized in that: can also add any or its combination in humectant or stabilizing agent or thickener or the odor mask; Humectant includes but not limited to one or more any combinations in polyalcohol such as glycerine or propane diols, polyethylene glycol, pyrrolidone sodium carboxylate, amide-type humectant, mucopolysaccharides, panthenol, jojoba oil, natural plant extracts, hyaluronic acid, double hyaluronic acid, ceramide, silk-fibroin/silk peptide class humectant, collagen, glucosan derivative, chitin shitosan and derivative thereof, 1-alkyl glycerol ether compound, the ethoxy phosphoamide; Stabilizing agent comprises but is not limited to bronopol, acid-base modifier; Thickener includes but not limited to hydroxyethylcellulose, hydroxypropyl cellulose, HPMC, polyethylene glycol, the compound based on polyethylene glycol, polyacrylamide, polyacrylamide methyl propane sulfonic acid, butylation PVP, polyglycereol-10 behenates/eicosane diacid ester, acrylate copolymer, based on one or more any combinations in the polymer of acrylate; Odor mask includes but not limited to essence, single-propylene glycol.
6. composition according to claim 5 is characterized in that: composition can be made liquid preparation, gel, spray or coating/be adsorbed on the base material.
7. coating according to claim 6/be adsorbed in the form on the base material includes but are not limited to composition is wiped the annex solution that towel, face are wiped towel as wet sanitary napkins, wet wiping towel, hand.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110151341.5A CN102246794B (en) | 2011-06-08 | 2011-06-08 | A kind of composition of killing microorganisms |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110151341.5A CN102246794B (en) | 2011-06-08 | 2011-06-08 | A kind of composition of killing microorganisms |
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| CN102246794A true CN102246794A (en) | 2011-11-23 |
| CN102246794B CN102246794B (en) | 2015-08-19 |
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| CN201110151341.5A Active CN102246794B (en) | 2011-06-08 | 2011-06-08 | A kind of composition of killing microorganisms |
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| CN102475513A (en) * | 2011-12-12 | 2012-05-30 | 浙江瑞邦日化有限公司 | Hydrogel type sanitary wet tissue and preparation method thereof |
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| CN103190399A (en) * | 2013-03-30 | 2013-07-10 | 江苏健裕健康医疗器械有限公司 | Medical isopropanol sterilizing disinfectant |
| CN103283722A (en) * | 2013-07-02 | 2013-09-11 | 宁波华欣医疗器械有限公司 | Compound disinfectant for hospital and application thereof |
| CN103340816A (en) * | 2013-07-17 | 2013-10-09 | 深圳市妍倩科技有限公司 | Special private care wet tissue for women |
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| CN111345314A (en) * | 2020-03-02 | 2020-06-30 | 上海星耀医学科技发展有限公司 | Disinfectant, disinfectant wet tissue and disinfection method for novel coronavirus |
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| CN108505329A (en) * | 2018-05-03 | 2018-09-07 | 上海高聚生物科技有限公司 | A kind of flame-proof antibiotic deodorization dressing liquid for disposable sanitary articles |
| CN111345314A (en) * | 2020-03-02 | 2020-06-30 | 上海星耀医学科技发展有限公司 | Disinfectant, disinfectant wet tissue and disinfection method for novel coronavirus |
| CN111374142A (en) * | 2020-03-12 | 2020-07-07 | 天天向上(宁波)医疗科技有限公司 | Disinfecting emulsion, preparation method thereof and disinfecting wet tissue prepared from disinfecting emulsion |
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| CN111513066A (en) * | 2020-04-29 | 2020-08-11 | 上海欧澄环境技术有限公司 | Preparation method of safe disinfectant for fragrant limited space |
| CN111602673A (en) * | 2020-06-05 | 2020-09-01 | 江苏中新瑞光学材料有限公司 | Nano photocatalyst and silver ion composite hydrophobic disinfectant |
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| CN113966741A (en) * | 2021-12-10 | 2022-01-25 | 西安文理学院 | Efficient and environment-friendly bactericide |
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