CN102107747A - Container for preventing microbial contamination of contact lens care solution after unsealing and preparation method thereof - Google Patents
Container for preventing microbial contamination of contact lens care solution after unsealing and preparation method thereof Download PDFInfo
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- CN102107747A CN102107747A CN 201110021546 CN201110021546A CN102107747A CN 102107747 A CN102107747 A CN 102107747A CN 201110021546 CN201110021546 CN 201110021546 CN 201110021546 A CN201110021546 A CN 201110021546A CN 102107747 A CN102107747 A CN 102107747A
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- filter membrane
- degerming filter
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- 238000011109 contamination Methods 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000012528 membrane Substances 0.000 claims abstract description 120
- 230000001954 sterilising effect Effects 0.000 claims abstract description 12
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 12
- 230000003750 conditioning effect Effects 0.000 claims description 90
- 239000007788 liquid Substances 0.000 claims description 90
- 229920001684 low density polyethylene Polymers 0.000 claims description 76
- 239000004702 low-density polyethylene Substances 0.000 claims description 76
- 229920003023 plastic Polymers 0.000 claims description 28
- 239000004033 plastic Substances 0.000 claims description 28
- 238000002347 injection Methods 0.000 claims description 21
- 239000007924 injection Substances 0.000 claims description 21
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 8
- 229920002678 cellulose Polymers 0.000 claims description 6
- 229920006393 polyether sulfone Polymers 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- 239000002033 PVDF binder Substances 0.000 claims description 3
- 238000009434 installation Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 6
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- -1 poly(vinylidene fluoride) Polymers 0.000 description 14
- 229920001903 high density polyethylene Polymers 0.000 description 13
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- 239000008188 pellet Substances 0.000 description 10
- 238000007664 blowing Methods 0.000 description 8
- 238000010276 construction Methods 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 229910000851 Alloy steel Inorganic materials 0.000 description 4
- 229920001617 Vinyon Polymers 0.000 description 4
- 238000000071 blow moulding Methods 0.000 description 4
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Abstract
The invention discloses a container for preventing microbial contamination of a contact lens care solution after being unsealed and a preparation method thereof; the container comprises an inner plug with a sterilization filter membrane, the inner plug with the sterilization filter membrane comprises an upper hollow cylinder and a lower hollow cylinder, the sterilization filter membrane and a circular ring, the cylinder at the lower end extends into a bottle mouth, the periphery of the cylinder at the lower end is tightly connected with the inner wall of the bottle mouth, the cylinder at the upper end protrudes out of the bottle mouth, the sterilization filter membrane is fixed in the circular ring, the circular ring is fixed at the upper end of an inner cavity of the cylinder at the lower end or in the inner cavity of the cylinder at the upper end, the diameter of the sterilization filter membrane in the circular ring is 10-16mm, the thickness of the sterilization filter membrane is 0.1-0.2mm, and. After the contact lens care solution is unsealed, the contact lens care solution can effectively prevent microbial contamination caused by contact with the outside in the use process of the care solution in the bottle. With the container of the present invention, the sample was 0CFU/ml in pure water in the bottle at 7 days after unsealing to simulate normal use.
Description
Technical field
The present invention relates to a kind of plastic bottle of splendid attire contact lense conditioning liquid, particularly relate to a kind of plastic bottle that can prevent the Kaifeng back microbial contamination of contact lense conditioning liquid packing and preparation method thereof.
Background technology
Contact lens normal contact lense conditioning liquid that uses in wearing process cleans, sterilizes, washes and preserve contact lense as the daily nursing articles for use.Usually the conditioning liquid in Kaifeng does not provide with germ-free condition.The contact lense conditioning liquid of city's field boundary use at present mainly is the plastic bottle form, and the user makes conditioning liquid drip outward/penetrate in bottle by the extruding body.But when cancelling squeese pressure, outside air just can be gone in the bottle by suck-back, and the use of repeated multiple times just can make conditioning liquid be subjected to the pollution of airborne Institute of Micro-biology.What is more can cause the contact lens wearers ocular infection because of Kaifeng back conditioning liquid microbial contamination.Therefore, based on the characteristics of prior art, international standard and People's Republic of China's pharmaceuticals industry standard have all been made regulation to the Kaifeng subject word of conditioning liquid.For this reason, the conditioning liquid manufacturer should and determine the Kaifeng subject word of conditioning liquid that this enterprise produces by standard-required according to the conditioning liquid prescription.Enterprise's determined conditioning liquid Kaifeng subject word is to carry out under the use control step than clean environment and standard, but the customer may make the conditioning liquid subject word that breaks a seal really be shorter than the Kaifeng subject word of manufacturer's specification sheets defined when reality is used because of factor such as the personal hygiene compliance of using storage environment, user, thereby makes the hygienic requirements of conditioning liquid out of reach mark Huaihe River defined.
As shown in Figure 1, 2, the plastic bottle of existing splendid attire contact lense conditioning liquid comprises bottle, interior plug, safety link and enclosing cover; General run of thins, bottle base portion diameter is 60-70mm, the bottleneck diameter of bottle is 9-12mm, the bottleneck of bottle is provided with interior plug, as shown in Figure 1, interior plug is arranged on bottle mouth position, interior plug is that two hollow cylinders are formed by connecting, and the cylinder diameter of lower end is less, and the cylinder diameter of upper end is bigger, the cylinder of lower end stretches in the bottleneck, with bottleneck inwall leak-tight joint, the cylinder of upper end protrudes bottleneck, and the cylinder diameter of upper end is 0.5-0.8mm, be provided with blind hole in the middle of the top end face sealing, top end face; The bottleneck portion of enclosing cover and bottle is threaded, and the enclosing cover inside center is provided with pointed cone, beyond the Great Wall blind hole in being used to puncture; The bottleneck portion lower end is provided with a safety link, is hollow cyclic structure, extensible bottleneck, shift out bottleneck after, further tighten bottle cap, the pointed cone in the bottle cap pierces through blind hole, the user can extrude the contact lense conditioning liquid by the blind hole after piercing through, and uses for the user.After the blind hole of the plastic bottle of existing splendid attire contact lense conditioning liquid is pierced, extrude in the contact lense conditioning liquid process, outside air suck-back is repeatedly gone in the bottle, makes conditioning liquid be subjected to airborne Institute of Micro-biology and pollutes.
Summary of the invention
The objective of the invention is to overcome the shortcoming of prior art, a kind of contact lense conditioning liquid Kaifeng back microbial contamination that both can effectively prevent is provided, the container of the convenient again splendid attire contact lense conditioning liquid that uses, guarantee plastic bottle conditioning liquid Kaifeng to shown in abandon peaceful property of health and practicality during day.
The degerming filter membrane is mainly used in the aseptic filtration of solution, prevents that the application that bacterium enters in the container is also very rare, does not see any report especially as yet at contact lense conditioning liquid fungi-proofing; And degerming filter membrane kind is more, and the requirement in use of contact lense conditioning liquid can conveniently become to ooze, and therefore, suitable effective diameter, thickness, surface micropore aperture etc. all will be complementary with the contact lense conditioning liquid.The present invention is directed to the hygienic issues that the Kaifeng back use of above-mentioned plastic bottle conditioning liquid occurs, in the interior plug of plastic bottle, install a degerming filter membrane composite set additional, do not influencing under the normal prerequisite of using of conditioning liquid, form fungi-proofing physical barriers effectively, thereby reach following purpose: 1) if conditioning liquid is subjected to unexpected microbial contamination in process of production in the bottle, germ in the conditioning liquid guarantees that oozing the conditioning liquid that is used to nurse eyeglass from bottle neck still can be germ-free condition after the interception of degerming filter membrane; 2) prevent back, conditioning liquid Kaifeng because the suck-back effect enters in the bottle airborne germ, thereby guarantee that to the full extent conditioning liquid still is germ-free condition in the bottle of back, product Kaifeng; 3) the convenient of contact lense conditioning liquid used after the degerming filter membrane was set up in assurance.
Purpose of the present invention is achieved through the following technical solutions:
Prevent the container of contact lense conditioning liquid Kaifeng back microbial contamination, comprise the bottle and the enclosing cover of container, bottle is divided into bottle base portion and bottleneck, and bottle base portion upper end is a bottleneck, and the bottle base portion is a hollow cylinder, and enclosing cover is connected with whorl of bottleneck; This container also comprises the interior plug of band degerming filter membrane, the interior plug of described band degerming filter membrane comprises two hollow cylinders, degerming filter membrane and annulus up and down, the lower end cylinder diameter is little, the upper end cylinder diameter is big, the cylinder of lower end stretches in the bottleneck, the cylinder periphery of lower end and bottleneck inwall leak-tight joint, the cylinder of upper end protrudes bottleneck, the degerming filter membrane is fixed in the annulus, annulus is fixed in cylinder internal cavities upper end, lower end or the upper end cylinder internal cavities, or is fixed on cylinder upper end, upper end end face; The diameter of degerming filter membrane in annulus is 10-16mm, and thickness is 0.1-0.2mm, and the aperture of degerming filter membrane 1 is 0.4-0.5 μ m.
For further realizing purpose of the present invention, described degerming filter membrane is selected PVDF membrane, poly (ether sulfone) film or mixed cellulose ester membrane for use.
The aperture of described degerming filter membrane is preferably 0.45 μ m.
The described plastic bottle of contact lense conditioning liquid microbial contamination that prevents also comprises safety link, and safety link is hollow cyclic structure, is movably arranged on bottleneck and bottle base portion junction; The cylindrical end face top, upper end of the interior plug of band degerming filter membrane does not have blind hole, and the enclosing cover inside center is provided with pointed cone.
Annulus partial width 〉=the 1mm of described annulus, annulus preferably prepares with low density polyethylene (LDPE).
Described degerming filter membrane is connected by the driving fit that chemical adhesion, heat seal and ultra-sonic welded realize with annulus.
Described degerming filter membrane is arranged on the cylindrical end face top, upper end of the interior plug of band degerming filter membrane by annulus.
Described degerming filter membrane thickness is preferably 0.15mm.
The described preparation method who prevents the plastic bottle of contact lense conditioning liquid microbial contamination; Following steps and technological condition:
(1) installation of degerming filter membrane: the degerming filter membrane is cut into the disk that diameter is 11～17mm, then the degerming filter membrane is embedded in the annulus of two circumferential widths greater than 1mm, make its driving fit by chemical adhesion, heat seal or ultra-sonic welded mode, making effective filtration diameter of degerming filter membrane is 10～16mm; Degerming filter membrane thickness is 0.1-0.2mm, and the aperture of degerming filter membrane is 0.4-0.5 μ m
(2) making of the interior plug of band degerming filter membrane: make interior plug by injection mo(u)lding, the described annulus that is provided with the degerming filter membrane of step (1) is fixed in cylinder internal cavities upper end, lower end or the upper end cylinder internal cavities by ultra-sonic welded, or is fixed on cylinder upper end, upper end end face;
(3) making of plastic bottle: make bottle and enclosing cover respectively;
(4) bottle with the plastic bottle of plug and step (3) gained in the band degerming filter membrane of step (2) gained carries out radiation sterilization, so that the first packing of all contact conditioning liquids is germ-free condition.
With respect to prior art, the present invention has following advantage and beneficial effect:
1. can prevent back, conditioning liquid Kaifeng because the suck-back effect enters in the bottle airborne germ, thereby guarantee that to the full extent conditioning liquid still is germ-free condition in the bottle of back, product Kaifeng.
2. if a conditioning liquid is subjected to unexpected microbial contamination in process of production in the bottle, the germ in the conditioning liquid guarantees that oozing the conditioning liquid that is used to nurse eyeglass from bottle neck still can be germ-free condition after the interception of degerming filter membrane.
3. be used to make general being easy to get of raw MAT'L of the unitized construction that prevents the Kaifeng back microbial contamination of contact lense conditioning liquid packing, and the preparation technology of plastic assembly is uncomplicated.
Description of drawings
Fig. 1 is the plastic bottle structural representation of existing splendid attire contact lense conditioning liquid.
Fig. 2 is the interior plug structure scheme drawing among Fig. 1.
Fig. 3 is the structure of container scheme drawing that the present invention prevents the microbial contamination of contact lense conditioning liquid.
Fig. 4 is degerming filter membrane and an annulus scheme of installation among Fig. 3.
Fig. 5 is the structural representation of filling in the band degerming filter membrane among Fig. 3.
The specific embodiment
In order further to understand the present invention, the invention will be further described below in conjunction with drawings and Examples, but the scope of protection of present invention is not limited to the scope that embodiment represents.
Shown in Fig. 3-5, prevent the container of contact lense conditioning liquid microbial contamination, comprise the bottle 4 of container, interior plug 3, loopful 6 and the enclosing cover of band degerming filter membrane; Bottle 4 is divided into bottle base portion and bottleneck 5, and bottle base portion upper end is a bottleneck 5, and the bottle base portion is a hollow cylinder, and diameter is 60-70mm; Bottleneck 5 diameters are 9-12mm; The interior plug 3 of band degerming filter membrane comprises two hollow cylinders, degerming filter membrane 1 and annulus 2, the lower end cylinder diameter is less, the upper end cylinder diameter is bigger, the cylinder of end stretches in the bottleneck, degerming filter membrane 1 is fixed in the annulus 2, annulus 2 is fixed in cylinder internal cavities upper end, lower end or the upper end cylinder internal cavities, and the cylinder of lower end and bottleneck inwall leak-tight joint are preferably the lower end cylinder by laser welding and bottleneck inwall leak-tight joint; The cylinder of upper end protrudes bottleneck, and the cylinder diameter of upper end is 0.5-0.8mm, is provided with blind hole 7 in the middle of the cylinder top end face sealing of upper end, top end face; The diameter of degerming filter membrane 1 in annulus 2 is 11-17mm, and thickness is 0.1-0.2mm, the preferred 0.15mm of degerming filter membrane 1 thickness, and the aperture of degerming filter membrane 1 is 0.4-0.5 μ m (micropore size on the surface of degerming filter membrane); Described degerming filter membrane is preferably used PVDF membrane, poly (ether sulfone) film or mixed cellulose ester membrane.The bottleneck 5 of enclosing cover and bottle 4 is threaded, and the enclosing cover inside center is provided with pointed cone, is used to puncture the blind hole on the interior plug 3 of being with the degerming filter membrane; Bottleneck 5 lower ends are provided with a safety link 6, and safety link 6 is hollow cyclic structure, extensible bottleneck 5, shift out bottleneck after, further tighten bottle cap, the pointed cone in the bottle cap pierces through blind hole, the user can extrude the contact lense conditioning liquid by the blind hole after piercing through, and uses for the user.Annulus partial width 〉=the 1mm of annulus 2, annulus 2 preferably prepares with low density polyethylene (LDPE); Blind hole plastic film thickness is preferably .05～0.10mm.Degerming filter membrane 1 can pass through chemical adhesion, heat seal and ultra-sonic welded with the driving fit of annulus 2 to be realized.Bottle 4 preferably by LDPE (Low-density polyethylene plastics) and high-density polyethylene plastics in mass ratio 0～50: 50 ratio is mixed.
Another prevents the container of contact lense conditioning liquid microbial contamination, mainly comprises the interior plug 3 and the enclosing cover of bottle 4, band degerming filter membrane; Basic identical on the structure with the above-mentioned container that prevents the back microbial contamination of contact lense conditioning liquid Kaifeng, difference is that enclosing cover inside does not have pointed cone, do not have safety link, be provided with through hole at the cylindrical end face top, upper end of the interior plug 3 of being with the degerming filter membrane, rather than blind hole.
Also has a kind of container that prevents the microbial contamination of contact lense conditioning liquid, structure and above-mentioned another prevent that the structure of container of contact lense conditioning liquid Kaifeng back microbial contamination is basic identical, difference is, cylindrical end face top, upper end at the interior plug 3 of being with the degerming filter membrane does not have through hole, and degerming filter membrane 1 is arranged on the cylindrical end face top, upper end of the interior plug 3 of band degerming filter membrane by annulus 2.
The preparation method of the container that prevents the back microbial contamination of contact lense conditioning liquid Kaifeng shown in above-mentioned Fig. 3-5 comprises the steps:
(1) container machine-shaping: low density polyethylene (LDPE) pellet and high density polyethylene (HDPE) material are fully mixed by mass ratio at 70: 30, pour into then in bottle blowing machine (the emerging SYC-45 of the industry) charging basket.Carry out bottle blowing by following blow molding process condition: 1. plasticization temperature: main barrel one temperature is controlled to be 168 ℃, and the temperature of main barrel two and main barrel three is controlled to be 172 ℃; 2. die head temperature is controlled to be 175 ℃; 3. the moulding single cycle time is 20Sec.
(2) making of band low density polyethylene (LDPE) periphery degerming filter membrane: with thickness is 0.15mm, and the aperture of degerming filter membrane 1 is that 0.45 μ m poly(vinylidene fluoride) tunica fibrosa (millipore company) places on the punch press workplatform, and following lining polyurethane is used
Alloy steel dash and to carry out punching at the poly(vinylidene fluoride) tunica fibrosa, promptly
Poly(vinylidene fluoride) degerming filter membrane.Then it being sandwiched in two internal diameters is
External diameter is
Thickness is in the LDPE (Low-density polyethylene plastics) ring of 0.5mm.The three is placed in ultrasonic bonding machine (as, a source SD1500) anchor clamps again, by ultra-sonic welded the three is merged, the ultra-sonic welded condition is: 29 milliseconds of weld times, 17 milliseconds of retard times, 14 milliseconds of firm times, operation pressure 0.35MPa.The degerming membrane filtration diameter of this routine gained is 10.0mm.
(3) making of plug in the LDPE (Low-density polyethylene plastics): the low density polyethylene (LDPE) pellet is placed the charging basket of injection machine (as reaching bright M50), carry out injection mo(u)lding in the usual way.Injecting condition: clamp force is that 50T, injection temperature are that 230～250 ℃, injection pressure are that 50～60kPa, dwell time are 3～5Sec.
(4) making of plug in the band degerming filter membrane: the station groove that the degerming filter membrane of the described band low density polyethylene (LDPE) of step (2) periphery is placed plug in the described LDPE (Low-density polyethylene plastics) of step (3), be fixed in then on the anchor clamps of ultrasonic bonding machine (as: a source SD1500), under 29 milliseconds of weld times, 17 milliseconds of retard times, 14 milliseconds of firm times, operation pressure 0.35MPa condition, carry out ultra-sonic welded.
(5) filling in capable radiation sterilization in the band degerming filter membrane with the low density polyethylene (LDPE) container of step (1) gained and step (4) gained handles.Radiant be the radioistotope cobalt (
60Co), dosage is 15K.
(6) a/s Recipe preparation contact lense conditioning liquid and carry out aseptic filtration, with the conditioning liquid quantitative filling to aseptic low density polyethylene (LDPE) container.
(7) the aseptic interior plug that has the degerming filter membrane is put into the container finish that fills conditioning liquid, be fixed in then on the anchor clamps of ultrasonic bonding machine (as: a source SD1500), under 29 milliseconds of weld times, 17 milliseconds of retard times, 14 milliseconds of firm times, operation pressure 0.35MPa condition, carry out ultra-sonic welded.
(8) on container, put safety link and enclosing cover, promptly obtain to prevent to pack the contact lense conditioning liquid of Kaifeng back microbial contamination.
Prevent the preparation method of the container of contact lense conditioning liquid Kaifeng back microbial contamination, comprise the steps:
(1) container machine-shaping: low density polyethylene (LDPE) pellet and high density polyethylene (HDPE) material are fully mixed by mass ratio at 70: 30, pour into then in bottle blowing machine (the emerging SYC-45 of the industry) charging basket.Carry out bottle blowing by following blow molding process condition: 1. plasticization temperature: main barrel one temperature is controlled to be 168 ℃, and the temperature of main barrel two and main barrel three is controlled to be 175 ℃; 2. die head temperature is controlled to be 175 ℃; 3. the moulding single cycle time is 20Sec.
(2) making of band low density polyethylene (LDPE) periphery degerming filter membrane: with thickness is 0.15mm, and the aperture of degerming filter membrane 1 is that the poly(vinylidene fluoride) tunica fibrosa (Millipore company) of 0.45 μ m places on the punch press workplatform, and following lining polyurethane is used
Alloy steel dash and to carry out punching at the poly(vinylidene fluoride) tunica fibrosa, promptly
0.45 μ poly(vinylidene fluoride) degerming filter membrane.Then it being sandwiched in two internal diameters is
External diameter is
Thickness is in the LDPE (Low-density polyethylene plastics) ring of 0.5mm.Scribble then and the three is solidificated in the low density polyethylene (LDPE) seal ring 160 ℃ of curing 3Sec. by polyethylene hot-melt adhesive.The degerming membrane filtration diameter of this routine gained is 16mm.
(3) vinyon (LDPE: HDPE=70: 30, mass ratio) making of plug in: by mass ratio, 70% low density polyethylene (LDPE) pellet and 30% pellets of high density polyethylene are placed the charging basket of injection machine (as reaching bright M50), carry out injection mo(u)lding in the usual way.Injecting condition: clamp force is that 50T, injection temperature are that 250～260 ℃, injection pressure are that 50～60kPa, dwell time are 5～7Sec.
(4) making of plug in the band degerming filter membrane: the station groove that the degerming filter membrane of the described band low density polyethylene (LDPE) of step (2) periphery is placed plug in the described vinyon of step (3), be fixed in then on the anchor clamps of ultrasonic bonding machine (as: a source SD1500), under 29 milliseconds of weld times, 17 milliseconds of retard times, 14 milliseconds of firm times, operation pressure 0.35MPa condition, carry out ultra-sonic welded.
(5) filling in capable radiation sterilization in the band degerming filter membrane with the polyethylene can of step (1) gained and step (4) gained handles.Radiant be the radioistotope cobalt (
60Co), dosage is 15K.
(6) a/s Recipe preparation contact lense conditioning liquid and carry out aseptic filtration, with the conditioning liquid quantitative filling to aseptic low density polyethylene (LDPE) container.
(7) the aseptic interior plug that has the degerming filter membrane is put into the container finish that fills conditioning liquid, be fixed in then on the anchor clamps of ultrasonic bonding machine (as: a source SD1500), under 29 milliseconds of weld times, 17 milliseconds of retard times, 14 milliseconds of firm times, operation pressure 0.35MPa condition, carry out ultra-sonic welded.
(8) on container, put safety link and enclosing cover, promptly obtain to prevent to pack the contact lense conditioning liquid of Kaifeng back microbial contamination.
Embodiment 3
Prevent the preparation method of the container of contact lense conditioning liquid Kaifeng back microbial contamination, comprise the steps:
(1) container machine-shaping: low density polyethylene (LDPE) pellet and high density polyethylene (HDPE) material are fully mixed by mass ratio at 70: 30, pour into then in bottle blowing machine (the emerging SYC-45 of the industry) charging basket.Carry out bottle blowing by following blow molding process condition: 1. plasticization temperature: main barrel one temperature is controlled to be 168 ℃, and the temperature of main barrel two and main barrel three is controlled to be 172 ℃; 2. die head temperature is controlled to be 175 ℃; 3. the moulding single cycle time is 20Sec.
(2) making of band low density polyethylene (LDPE) periphery degerming filter membrane: with thickness is 0.15mm, and the aperture of degerming filter membrane 1 is that polyethersulfone (millipore company) film of 0.45 μ m places on the punch press workplatform, and following lining polyurethane is used
Alloy steel dash and to carry out punching at the polyether sulfone fiber film, promptly
0.45 μ polyether sulfone fiber degerming filter membrane.Being placed on a slice internal diameter then is
External diameter is
Thickness is on the LDPE (Low-density polyethylene plastics) ring of 0.5mm, again both are placed the injection mould of special structure, by injection moulding the three is merged, injecting condition is: clamp force is that 50T, injection temperature are that 230～250 ℃, injection pressure are that 50～60kPa, dwell time are 1～3Sec.The degerming membrane filtration diameter of this routine gained is 13mm.
(3) making of plug in the LDPE (Low-density polyethylene plastics): the low density polyethylene (LDPE) pellet is placed the charging basket of injection machine (as reaching bright M50), carry out injection mo(u)lding in the usual way.Injecting condition: clamp force is that 50T, injection temperature are that 230～250 ℃, injection pressure are that 50～60kPa, dwell time are 3～5Sec.
(4) making of plug in the band degerming filter membrane: the station groove that the degerming filter membrane of the described band low density polyethylene (LDPE) of step (2) periphery is placed plug in the described LDPE (Low-density polyethylene plastics) of step (3), be fixed in then on the anchor clamps of ultrasonic bonding machine (as: a source SD1500), under 29 milliseconds of weld times, 17 milliseconds of retard times, 14 milliseconds of firm times, operation pressure 0.35MPa condition, carry out ultra-sonic welded.
(5) filling in capable radiation sterilization in the band degerming filter membrane with the low density polyethylene (LDPE) container of step (1) gained and step (4) gained handles.Radiant be the radioistotope cobalt (
60Co), dosage is 15K.
(6) a/s Recipe preparation contact lense conditioning liquid and carry out aseptic filtration, with the conditioning liquid quantitative filling to aseptic low density polyethylene (LDPE) container.
(7) the aseptic interior plug that has the degerming filter membrane is put into the container finish that fills conditioning liquid, be fixed in then on the anchor clamps of ultrasonic bonding machine (as: a source SD1500), under 29 milliseconds of weld times, 17 milliseconds of retard times, 14 milliseconds of firm times, operation pressure 0.35MPa condition, carry out ultra-sonic welded.
(8) on container, put safety link and enclosing cover, promptly obtain to prevent to pack the contact lense conditioning liquid of Kaifeng back microbial contamination.
Prevent the preparation method of the container of contact lense conditioning liquid Kaifeng back microbial contamination, comprise the steps:
(1) container machine-shaping: low density polyethylene (LDPE) pellet and high density polyethylene (HDPE) material are fully mixed by mass ratio at 70: 30, pour into then in bottle blowing machine (the emerging SYC-45 of the industry) charging basket.Carry out bottle blowing by following blow molding process condition: 1. plasticization temperature: main barrel one temperature is controlled to be 168 ℃, and the temperature of main barrel two and main barrel three is controlled to be 172 ℃; 2. die head temperature is controlled to be 175 ℃; 3. the moulding single cycle time is 20Sec.
(2) making of band low density polyethylene (LDPE) periphery degerming filter membrane: with thickness is 0.15mm, and the aperture of degerming filter membrane 1 is that mixed cellulose ester (millipore company) film of 0.45 μ m places on the punch press workplatform, and following lining polyurethane is used
Alloy steel dash and to carry out punching at mixed cellulose ester membrane, promptly
0.45 μ mixed cellulose ester degerming filter membrane.Then it being sandwiched in two internal diameters is
External diameter is
Thickness is in the LDPE (Low-density polyethylene plastics) ring of 0.5mm.The three is placed ultrasonic bonding machine (as: a source SD1500) anchor clamps again, by ultra-sonic welded the three is merged, the ultra-sonic welded condition is: 29 milliseconds of weld times, 17 milliseconds of retard times, 14 milliseconds of firm times, operation pressure 0.35MPa.The degerming membrane filtration diameter of this routine gained is 12mm.
(3) vinyon (LDPE: HDPE=50: 50, mass ratio) making of plug in: by mass ratio, 50% low density polyethylene (LDPE) pellet and 50% pellets of high density polyethylene are placed the charging basket of injection machine (as reaching bright M50), carry out injection mo(u)lding in the usual way.Injecting condition: clamp force is that 50T, injection temperature are that 245～255 ℃, injection pressure are that 50～60kPa, dwell time are 4～6Sec.
(4) making of plug in the band degerming filter membrane: the station groove that the degerming filter membrane of the described band low density polyethylene (LDPE) of step (2) periphery is placed plug in the described vinyon of step (3), be fixed in then on the anchor clamps of ultrasonic bonding machine (as: a source SD1500), under 29 milliseconds of weld times, 17 milliseconds of retard times, 14 milliseconds of firm times, operation pressure 0.35MPa condition, carry out ultra-sonic welded.
(5) filling in capable radiation sterilization in the band degerming filter membrane with the low density polyethylene (LDPE) container of step (1) gained and step (4) gained handles.Radiant be the radioistotope cobalt (
60Co), dosage is 15K.
(6) a/s Recipe preparation contact lense conditioning liquid and carry out aseptic filtration, with the conditioning liquid quantitative filling to aseptic low density polyethylene (LDPE) container.
(7) the aseptic interior plug that has the degerming filter membrane is put into the container finish that fills conditioning liquid, be fixed in then on the anchor clamps of ultrasonic bonding machine (as: a source SD1500), under 29 milliseconds of weld times, 17 milliseconds of retard times, 14 milliseconds of firm times, operation pressure 0.35MPa condition, carry out ultra-sonic welded.
(8) on container, put safety link and enclosing cover, promptly obtain to prevent to pack the contact lense conditioning liquid of Kaifeng back microbial contamination.
Band degerming filter membrane composite structure equipment and the rear defence microbial contamination experimental design of traditional common plastics packing Kaifeng: in sterilized container, inject sterile pure water, distinguish plug and the common interior plug of tradition in the involution band degerming filter membrane unitized construction then, the simulation of back, Kaifeng is normally used.After the 7th day pure water in the bottle is carried out sterility test by 2010 editions second appendix XI H of the Pharmacopoeia of the People's Republic of China " sterility test method ".Check result is: use the sample microbial biomass of filling in as hermetically-sealed construction in the band degerming filter membrane unitized construction to be 0CFU/ml, and use the common interior plug of tradition to be 86CFU/ml as the sample microbial biomass of hermetically-sealed construction.
Because the aperture of degerming filter membrane is 0.45 μ m, so it oozes speed from bottle neck and is not so good as not conditioning liquid with the degerming filter membrane device when filtering the contact lense conditioning liquid that certain viscosity is arranged.But in the above-described embodiments when the degerming filter membrane effectively filters diameter 〉=12mm, the speed that conditioning liquid oozes from bottle neck and the volume energy of drop satisfy the normal use of contact lens wearers.In addition, use the dynamics of band degerming filter membrane conditioning liquid at crumpling process for alleviating the user, container body is with the preferred low density polyethylene (LDPE) of material.Suitable bottle material can make nursing drop speed of the present invention satisfy the requirement of user's daily nursing with the combination of material and filter membrane diameter.
More than cited 4 preparation embodiment and sterility test result as can be seen, use the hermetically-sealed construction of filling in the band degerming filter membrane unitized construction as the contact lense conditioning liquid, because the physical barriers effect that the degerming filter membrane is played, the degree that polluted by external microbe in the back use of product Kaifeng is greatly reduced, thereby actv. has solved the hygienic issues of back, long-term puzzlement contact lense conditioning liquid Kaifeng content.Be used to make general being easy to get of material of plug in the band degerming filter membrane unitized construction, assembly course of processing technology is uncomplicated.So the present invention has very high practical value.
The various example of the present invention only is as illustration.Based on aforementioned description, this area professional can carry out various changes or improvement easily.Therefore, wish within the spirit and scope that all various changes or improvement be included in claims.
Claims (9)
1. prevent the container of contact lense conditioning liquid Kaifeng back microbial contamination, comprise the bottle and the enclosing cover of container, bottle is divided into bottle base portion and bottleneck, and bottle base portion upper end is a bottleneck, and the bottle base portion is a hollow cylinder, and enclosing cover is connected with whorl of bottleneck; It is characterized in that: this container also comprises the interior plug of band degerming filter membrane, the interior plug of described band degerming filter membrane comprises two hollow cylinders, degerming filter membrane and annulus up and down, the lower end cylinder diameter is little, the upper end cylinder diameter is big, the cylinder of lower end stretches in the bottleneck, the cylinder periphery of lower end and bottleneck inwall leak-tight joint, the cylinder of upper end protrudes bottleneck, the degerming filter membrane is fixed in the annulus, annulus is fixed in cylinder internal cavities upper end, lower end or the upper end cylinder internal cavities, or is fixed on cylinder upper end, upper end end face; The diameter of degerming filter membrane in annulus is 10-16mm, and thickness is 0.1-0.2mm, and the aperture of degerming filter membrane 1 is 0.4-0.5 μ m.
2. the container that prevents the back microbial contamination of contact lense conditioning liquid Kaifeng according to claim 1, it is characterized in that: described degerming filter membrane is selected PVDF membrane, poly (ether sulfone) film or mixed cellulose ester membrane for use.
3. the container that prevents the back microbial contamination of contact lense conditioning liquid Kaifeng according to claim 1, it is characterized in that: the aperture of described degerming filter membrane is 0.45 μ m.
4. the container that prevents the back microbial contamination of contact lense conditioning liquid Kaifeng according to claim 1, it is characterized in that: the described plastic bottle of contact lense conditioning liquid Kaifeng back microbial contamination that prevents also comprises safety link, safety link is hollow cyclic structure, is movably arranged on bottleneck and bottle base portion junction; The cylindrical end face top, upper end of the interior plug of band degerming filter membrane does not have blind hole, and the enclosing cover inside center is provided with pointed cone.
5. the container that prevents the back microbial contamination of contact lense conditioning liquid Kaifeng according to claim 1, it is characterized in that: the annulus partial width 〉=1mm of described annulus, annulus prepares with low density polyethylene (LDPE).
6. the container that prevents the back microbial contamination of contact lense conditioning liquid Kaifeng according to claim 1 is characterized in that: described degerming filter membrane is connected by the driving fit that chemical adhesion, heat seal and ultra-sonic welded realize with annulus.
7. the container that prevents the back microbial contamination of contact lense conditioning liquid Kaifeng according to claim 1 is characterized in that: described degerming filter membrane is arranged on the cylindrical end face top, upper end of the interior plug of band degerming filter membrane by annulus.
8. the container that prevents the back microbial contamination of contact lense conditioning liquid Kaifeng according to claim 1, it is characterized in that: described degerming filter membrane 1 thickness is 0.15mm.
9. the described preparation method who prevents the container of contact lense conditioning liquid Kaifeng back microbial contamination of claim 1; Its feature comprises the steps and technological condition:
(1) installation of degerming filter membrane: the degerming filter membrane is cut into the disk that diameter is 11～17mm, then the degerming filter membrane is embedded in the annulus of two circumferential widths greater than 1mm, make its driving fit by chemical adhesion, heat seal or ultra-sonic welded mode, making effective filtration diameter of degerming filter membrane is 10～16mm; Degerming filter membrane thickness is 0.1-0.2mm, and the aperture of degerming filter membrane is 0.4-0.5 μ m
(2) making of the interior plug of band degerming filter membrane: make interior plug by injection mo(u)lding, the described annulus that is provided with the degerming filter membrane of step (1) is fixed in cylinder internal cavities upper end, lower end or the upper end cylinder internal cavities by ultra-sonic welded, or is fixed on cylinder upper end, upper end end face;
(3) making of plastic bottle: make bottle and enclosing cover respectively;
(4) bottle with the plastic bottle of plug and step (3) gained in the band degerming filter membrane of step (2) gained carries out radiation sterilization, so that the first packing of all contact conditioning liquids is germ-free condition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110021546 CN102107747A (en) | 2011-01-19 | 2011-01-19 | Container for preventing microbial contamination of contact lens care solution after unsealing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110021546 CN102107747A (en) | 2011-01-19 | 2011-01-19 | Container for preventing microbial contamination of contact lens care solution after unsealing and preparation method thereof |
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| CN102107747A true CN102107747A (en) | 2011-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1065838A (en) * | 1991-02-19 | 1992-11-04 | 派尔金汤·维森凯尔公司 | Distributing box |
| US20040074925A1 (en) * | 2000-11-13 | 2004-04-22 | Michel Faurie | Drip liquid dispenser |
| WO2010013131A1 (en) * | 2008-07-31 | 2010-02-04 | Laboratoires Thea | Bottle for packaging liquid that is to be dispensed drop by drop, with antibacterial protection |
-
2011
- 2011-01-19 CN CN 201110021546 patent/CN102107747A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1065838A (en) * | 1991-02-19 | 1992-11-04 | 派尔金汤·维森凯尔公司 | Distributing box |
| US20040074925A1 (en) * | 2000-11-13 | 2004-04-22 | Michel Faurie | Drip liquid dispenser |
| WO2010013131A1 (en) * | 2008-07-31 | 2010-02-04 | Laboratoires Thea | Bottle for packaging liquid that is to be dispensed drop by drop, with antibacterial protection |
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Application publication date: 20110629 |