CN101773689B - Surgical repairing patch - Google Patents
Surgical repairing patch Download PDFInfo
- Publication number
- CN101773689B CN101773689B CN 201010134115 CN201010134115A CN101773689B CN 101773689 B CN101773689 B CN 101773689B CN 201010134115 CN201010134115 CN 201010134115 CN 201010134115 A CN201010134115 A CN 201010134115A CN 101773689 B CN101773689 B CN 101773689B
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- CN
- China
- Prior art keywords
- patch
- surgery
- tissue
- hyaluronic acid
- thickness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 22
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 22
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims description 45
- -1 poly(ethylene oxide) Polymers 0.000 claims description 25
- 238000001356 surgical procedure Methods 0.000 claims description 17
- BPMFZUMJYQTVII-UHFFFAOYSA-N guanidinoacetic acid Chemical compound NC(=N)NCC(O)=O BPMFZUMJYQTVII-UHFFFAOYSA-N 0.000 claims description 12
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 10
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 10
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 10
- 229920001610 polycaprolactone Polymers 0.000 claims description 9
- 239000004632 polycaprolactone Substances 0.000 claims description 9
- 239000004626 polylactic acid Substances 0.000 claims description 7
- 238000009941 weaving Methods 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 229950000845 politef Drugs 0.000 claims description 6
- 229920000573 polyethylene Polymers 0.000 claims description 6
- 229920001155 polypropylene Polymers 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 230000003068 static effect Effects 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 abstract description 12
- 108010035532 Collagen Proteins 0.000 abstract description 12
- 238000010041 electrostatic spinning Methods 0.000 abstract description 5
- 229920000642 polymer Polymers 0.000 abstract description 5
- 229920001436 collagen Polymers 0.000 abstract description 3
- 208000031737 Tissue Adhesions Diseases 0.000 abstract description 2
- 230000003115 biocidal effect Effects 0.000 abstract description 2
- 231100001083 no cytotoxicity Toxicity 0.000 abstract description 2
- 210000004197 pelvis Anatomy 0.000 abstract 1
- 239000002861 polymer material Substances 0.000 abstract 1
- 238000009987 spinning Methods 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 16
- 238000005516 engineering process Methods 0.000 description 7
- 229920002521 macromolecule Polymers 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 229920000747 poly(lactic acid) Polymers 0.000 description 3
- 239000004753 textile Substances 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 238000001523 electrospinning Methods 0.000 description 2
- 150000002596 lactones Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 108010022355 Fibroins Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000032420 Latent Infection Diseases 0.000 description 1
- 229920004933 Terylene® Polymers 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 239000002121 nanofiber Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The invention provides a tissue repairing patch, which is formed by applying hyaluronic acid film or mixture film of hyaluronic acid and collagen on the surface of high polymer surgical biological patch. The high polymer surgical biological patch is made of artificially synthesized high polymer material. The high polymer surgical biological patch can be prepared by electrostatic spinning process or monofilament spinning process. The patch has improved affinity between biocompatibility and tissue without influencing other biological and mechanical properties and has antibiotic property simultaneously. In addition, filmed-coated patch reduces tissue adhesion and cavum pelvis pain. Moreover, the surgical biological patch has no cytotoxicity and can not cause harm to human bodies.
Description
Technical field:
The invention belongs to biomedical material, be specifically related to a kind of biology patching material that can in multiple surgical operation, be used for repairing defective tissue or organ.
Background technology:
Artificial material is applied to the main flow that the surgery invasive is repaired has become the modern surgery development.Mainly contain artificial bio-membrane's material and biomaterial two big classes at present.Artificial bio-membrane's material is based on polymer: as terylene, carbon fiber, polyethylene, polypropylene, politef, polylactic acid, polyvinyl alcohol, poly(ethylene oxide), poly-own lactone and polylactic acid-glycolic guanidine-acetic acid etc.; Biological material source has: human body corium, animal membrane tissue, animal corium etc.Though material select to be gone up variation, also reaches certain effect in the practical application, also has various problems, still make great efforts to seek to solve a series of problems after material enters human body at present, as the problem of biocompatibility, the allosome exclusive problem.Desirable material is to realize that stability is high, biocompatibility is good, can induce the fibrous tissue of self to grow into, final support and the fixation that realizes repair tissue.
In recent years, the electro spinning nano fiber material can imitate the structure of extracellular matrix for the preparation of medical surgical sticking patch provides a brand-new solution on the material structure that static is woven into.The natural macromolecular material that makes with electrostatic spinning technique improve biocompatibility and biological activity, but its mechanical strength is difficult to meet the demands.Though and tissue patch elasticity and the intensity of utilizing the absorbable polymer of synthetic such as polylactic acid, polyvinyl alcohol, poly(ethylene oxide), poly-own lactone and polylactic acid-glycolic guanidine-acetic acid etc. to make through electrospinning process can satisfy the demands, but can cause localized liquid to gather, aseptic inflammation is a little less than the biocompatibility relative thin.In order to address the above problem, CN101507843A adopts by collagen protein or/and fibroin albumen or/and polycaprolactone is mixed with mixture by mass percentage, utilizes electrostatic spinning technique to prepare the medical surgical sticking patch with polylactic acid.Though the biology patching material that this method prepares has good biomechanical property and biocompatibility, it does not also have enough universalities.
Though the development of static textile technology, for the application of medical bio sticking patch provides a kind of new selection, but the macromolecular material that some can not absorb, as: polyethylene, polypropylene, politef or its mixture etc., utilize the film-making of static textile technology, also have technical barrier, and the sticking patch of this class material is in some clinical practice field, as also irreplaceable in the Reconstruction at the bottom of the basin.But the macromolecular material that this class can not absorb in actual applications, has the possibility of inserting trouble and latent infection of sticking patch in the operation.
In a word, along with development of science and technology, according to the application characteristic of the present all kinds substitution material of grasping, different tissues, different parts are to the different demands of patching material, the personalized patching material that well-designed manufacturing is suitable.
Summary of the invention:
Deficiency at existing biology patching material existence, the object of the present invention is to provide a kind of surgery biological sticking patch with good biological mechanical property and biocompatibility, and adopt production technology simple, can be made into all size and shape, satisfy the needs of clinical multiple surgical repair operation.
The present invention utilizes hyaluronic acid or hyaluronic acid and collagen protein mixture biological coating technology, in the biomechanical property that does not influence the tissue patch that tissue patch that electrostatic spinning technique makes and monofilament textile technology make, improve biocompatibility and with the affinity of body tissue.And can be made into all size and shape, satisfy clinical multiple demand.
Tissue repairing patch of the present invention is for having hyaluronic acid membrane or hyaluronic acid and collagen protein blend films on the surface of macromolecule surgery biological sticking patch.
Wherein, the thickness of the film of hyaluronic acid or hyaluronic acid and collagen protein mixture is the 2-15 micron.
Wherein, hyaluronic molecular weight is 1,000,000-2,200,000 dalton.
Wherein, the molecular weight 1500-3000 dalton of collagen protein.
Wherein, the material of described macromolecule surgery biological sticking patch is the synthetic macromolecular material.
Wherein, can to absorb macromolecular material be polylactic acid (PLA), polyvinyl alcohol (PVA), poly(ethylene oxide) (PEO), polycaprolactone (PCL), polylactic acid-glycolic guanidine-acetic acid (PLGA) or its mixture to described synthetic.
Wherein, can not to absorb macromolecular material be polyethylene, polypropylene, politef or its mixture to described synthetic.
Wherein, above-mentioned macromolecule surgery biological sticking patch adopts method of electrostatic spinning to make or monofilament weaving method makes.
The preparation method of tissue repairing patch of the present invention is: carry out coating film treatment on the surface of macromolecule surgery biological sticking patch with hyaluronic acid or hyaluronic acid and collagen protein mixture.
Beneficial effect of the present invention:
1, through the sticking patch of hyaluronic acid or hyaluronic acid and collagen protein mixture coating film treatment when not influencing its biomechanical property, improved the affinity of its biocompatibility and body tissue, also have antibiotic property simultaneously, can reduce pain.In addition, sticking patch inserted during the sticking patch behind the plated film was conducive to perform the operation.
2, the surgery that utilizes above method to make biological sticking patch no cytotoxicity can not produce harm to health.
The specific embodiment:
Embodiment 1:
The synthetic macromolecular material is that polylactic acid (PLA), polyvinyl alcohol (PVA), poly(ethylene oxide) (PEO), polycaprolactone (PCL), polylactic acid-glycolic guanidine-acetic acid (PLGA) or its mixture are made the flaky material that thickness is the demand shape of 0.6-1.2mm through static weaving method.Concentration is that the hyaluronic acid solution of 1-3% evenly is sprayed on the above-mentioned flaky material through spray gun, and thickness is the 2-15 micron, namely gets surgery patching material of the present invention after the drying.
Embodiment 2:
The synthetic macromolecular material is that polylactic acid (PLA), polyvinyl alcohol (PVA), poly(ethylene oxide) (PEO), polycaprolactone (PCL), polylactic acid-glycolic guanidine-acetic acid (PLGA) or its mixture are made the flaky material that thickness is the demand shape of 0.6-1.2mm through static weaving method.Be 1-3% hyaluronic acid solution and concentration for after the 1-2% collagen solution mixes with concentration, evenly be sprayed on the above-mentioned flaky material through spray gun that thickness is the 2-15 micron, namely gets surgery patching material of the present invention after the drying.
Embodiment 3:
The synthetic macromolecular material is that polyethylene, polypropylene, politef or its mixture are made the flaky material that thickness is the demand shape of 0.4-1mm through monofilament weaving method.The hyaluronic acid solution that with concentration is 1-3% evenly is sprayed on the above-mentioned flaky material through spray gun, and THICKNESS CONTROL namely gets surgery patching material of the present invention at the 2-15 micron after the drying.
Embodiment 4:
The synthetic macromolecular material is that polyethylene, polypropylene, politef or its mixture are made the flaky material that thickness is the demand shape of 0.4-1mm through monofilament weaving method.Be 1-3% hyaluronic acid solution and concentration for after the 1-2% collagen solution mixes with concentration, evenly be sprayed on the above-mentioned flaky material through spray gun that THICKNESS CONTROL namely gets surgery patching material of the present invention at the 2-15 micron after the drying.
The prepared surgery of the present invention has been compared following superiority with tissue patch with the product before the plated film:
1, because hyaluronic acid and collagen protein have excellent biological compatibility, so the prepared material good biocompatibility of the present invention;
2, since hyaluronic acid can reduce tissue be stained with glutinous, so the prepared material biology of the present invention can prevent wound healing the time the unnecessary tissue that produces be stained with glutinously, accelerate postoperative recovery; In addition, the sticking patch behind the plated film also can be avoided and the tissue adhesion in operation process, is convenient to medical personnel and inserts operation;
3, hyaluronic acid or hyaluronic acid and collagen protein blend films can induce patient's self fibrous tissue to grow into, and guide tissue regeneration realizes that finally the outstanding holder of autologous tissue and traction are fixing.
Claims (2)
1. a surgery is with the preparation method of tissue repairing patch, it is characterized in that: the synthetic macromolecular material is polylactic acid (PLA), polyvinyl alcohol (PVA), poly(ethylene oxide) (PEO), polycaprolactone (PCL), polylactic acid-glycolic guanidine-acetic acid (PLGA) or its mixture are made the flaky material that thickness is the demand shape of 0.6-1.2mm through static weaving method, concentration is 3%, hyaluronic molecular weight is 1,000,000-2,200,000 daltonian hyaluronic acid solution evenly is sprayed on the above-mentioned flaky material through spray gun, thickness is the 2-15 micron, namely gets the surgery tissue repairing patch after the drying.
2. a surgery is with the preparation method of tissue repairing patch, it is characterized in that: the synthetic macromolecular material is that polyethylene, polypropylene, politef or its mixture are made the flaky material that thickness is the demand shape of 0.4-1mm through monofilament weaving method, with concentration be 3%, hyaluronic molecular weight is 1,000,000-2,200,000 daltonian hyaluronic acid solution evenly is sprayed on the above-mentioned flaky material through spray gun, THICKNESS CONTROL namely gets the surgery tissue repairing patch at the 2-15 micron after the drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010134115 CN101773689B (en) | 2010-03-29 | 2010-03-29 | Surgical repairing patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010134115 CN101773689B (en) | 2010-03-29 | 2010-03-29 | Surgical repairing patch |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101773689A CN101773689A (en) | 2010-07-14 |
| CN101773689B true CN101773689B (en) | 2013-08-21 |
Family
ID=42510362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010134115 Expired - Fee Related CN101773689B (en) | 2010-03-29 | 2010-03-29 | Surgical repairing patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101773689B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698318A (en) * | 2012-03-02 | 2012-10-03 | 首都医科大学附属北京朝阳医院 | Biological-material complex patch |
| CN102631703A (en) * | 2012-04-20 | 2012-08-15 | 东华大学 | Three-dimensional non-support bone repairing patch and preparation method thereof |
| CN102921040A (en) * | 2012-11-09 | 2013-02-13 | 无锡中科光远生物材料有限公司 | Growth induction form absorbable patch |
| CN103800096B (en) * | 2012-11-14 | 2016-12-21 | 深圳迈普再生医学科技有限公司 | Pelvic floor dysfunction disease reparation is with implanting fiber diaphragm, preparation method and the medical apparatus and instruments containing it |
| CN104988561A (en) * | 2015-07-20 | 2015-10-21 | 江南大学 | Preparation method of bio-coating based on hyaluronic acid complex micelle |
| CN106901866A (en) * | 2015-12-22 | 2017-06-30 | 上海典范医疗科技有限公司 | Compound dural patch for preventing adhesion and preparation method thereof |
| CN105877871B (en) * | 2016-06-16 | 2017-08-04 | 中国医学科学院北京协和医院 | A kind of Pituitaryadenoma operation sticking patch and preparation method |
| CN109906091B (en) * | 2016-11-07 | 2021-10-15 | 郡是株式会社 | Biological tissue reinforcing material |
| CN106880874A (en) * | 2017-01-16 | 2017-06-23 | 东华大学 | A kind of manually compound hernia paster and preparation method thereof |
| US11944723B2 (en) | 2018-03-13 | 2024-04-02 | Institut Quimic De Sarria Cets Fundacio Privada | Vascular repair patch |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8172844B2 (en) * | 2004-10-06 | 2012-05-08 | Nobil Bio Ricerche S.R.L. | Bone implant device |
| CN101035572B (en) * | 2004-10-07 | 2010-12-08 | 纳幕尔杜邦公司 | Polysaccharide-based polymer tissue adhesive for medical use |
| CN101366954B (en) * | 2008-09-19 | 2013-03-20 | 乐普（北京）医疗器械股份有限公司 | Biocidal treatment method for biological coating medical device |
| CN101584612B (en) * | 2009-06-12 | 2011-11-09 | 广州迈普再生医学科技有限公司 | Regeneration type artificial blood vessel based on in-situ self stem cell technology and preparation method thereof |
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2010
- 2010-03-29 CN CN 201010134115 patent/CN101773689B/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN101773689A (en) | 2010-07-14 |
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Effective date of registration: 20161216 Address after: 213022 innovation and Technology Park, Xinbei District, Jiangsu, Changzhou, north of innovation and technology building, 313 Patentee after: Changzhou Boxin Biotechnology Co.,Ltd. Address before: 213022 innovation and Technology Park, Xinbei District, Jiangsu, Changzhou, north of innovation and technology building, 313 Patentee before: Yuan Guozhong |
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Address after: Floor 1, C4 West, No.9, Changyang Road, Wujin economic development zone, Changzhou City, Jiangsu Province Patentee after: 'the medical technology (Changzhou) Co.,Ltd. Address before: 213022 Innovation Zone, Xinbei science and Technology Park, Xinbei District, Jiangsu, Changzhou 313 Patentee before: Changzhou Boxin Biotechnology Co.,Ltd. |
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Granted publication date: 20130821 |