CN101357114A - Whitening antioxidation cosmetic compositions - Google Patents
Whitening antioxidation cosmetic compositions Download PDFInfo
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- CN101357114A CN101357114A CNA2008101569118A CN200810156911A CN101357114A CN 101357114 A CN101357114 A CN 101357114A CN A2008101569118 A CNA2008101569118 A CN A2008101569118A CN 200810156911 A CN200810156911 A CN 200810156911A CN 101357114 A CN101357114 A CN 101357114A
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- polygonin
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- whitening antioxidation
- antioxidation cosmetic
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Abstract
The invention provides a whitening antioxidant cosmetic composition which is characterized in that the composition contains polygonin. The polygonin inhibits tyrosinase activity, melanin production, also has the functions such as scavenging free radical, enhancing SOD activity, and the like, and shows good whitening anti-oxidation function. The whitening antioxidant cosmetic composition provided by the invention has the functions of skin whitening, anti-wrinkle and removing wrinkle, removing freckle, moisture, and so on.
Description
Technical field
The present invention relates to the compositions of cosmetic composition, particularly whitening antioxidation cosmetic compositions.
Background technology
Skin is the vital tissue of protection human internal organs, mainly is made of epidermal area, skin corium and subcutaneous tissue.Skin corium provides intensity and elasticity for skin.As time goes on, skin is old and feeble gradually, phenomenons such as wrinkle, cutis laxa occur.It has been generally acknowledged that free radical is to cause old and feeble main cause, therefore removes or prevent that oxygen-derived free radicals from being the research emphasis of the old cosmetics of removing wrinkle and resisting aging.The color of skin depends primarily in the skin contained how much melanic.The melanin building-up process is as follows: intracellular tyrosine generates the DOPA quinone under the effect of tryrosinase, and the DOPA quinone further is oxidized to dihydroxy indole after becoming dopachrome, generates melanin at last.In this course, tryrosinase plays pivotal role, and this enzymatic activity size is determining the quantity that melanin forms.Current whitening product great majority are based on restraint of tyrosinase.
(polydatin, PD) a kind of monomer for extracting in the dry root of Polygonaceae Polygonum herbaceos perennial Rhizoma Polygoni Cuspidati and the stem also claim polydatin to polygonin.Its chemical constitution is 3,4 ', 5-trihydroxy stilbene-3-β-D-glucoside.Studies show that in recent decades, polygonin have physiologically actives such as microcirculation improvement, blood fat reducing, antitumor, but the unexposed so far polygonin of crossing is used for skin nursing purposes or beautifying use.
Present inventor's medical herbs under study for action whitens in the process, finds that Rhizoma Polygoni Cuspidati extract has good whitening effect.Discover that further the main effective ingredient in the Rhizoma Polygoni Cuspidati extract is a polygonin.The obviously active and melanic generation of restraint of tyrosinase of polygonin, and extract selected repeatedly and make up, simultaneously, polygonin can improve the cell SOD activity, removes various free radicals, has tangible antioxidant effect.Based on these effects of polygonin, the inventor has developed a kind of make-up composition that contains polygonin, and it has excellent whitening and antioxidant effect; Simultaneously, said composition is the natural plant composition, has no side effect, and skin irritation is little, and stable in properties can promote the metabolism of skin, and the nutrition that improves skin is with healthy.
Summary of the invention
Whitening antioxidation cosmetic compositions provided by the invention, by weight percentage, the consumption of polygonin can be 0.001-10%, and preferred content is 0.05-1%.
Whitening antioxidation cosmetic compositions provided by the invention also contains the Radix Sanguisorbae extract, and this extract can obtain by conventional method.For example can with above-mentioned plant rhizome etc. with extract that solvent soaks or reflux after, filter, concentrate and obtain.Also can further separate purification processes.For example the extracting solution former state that above-mentioned solvent extraction is obtained or concentrate after extracting solution remove impurity by resin.Contain abundant polyphenol compound in the Radix Sanguisorbae extract.Plant polyphenol has good astriction, can make lax skin-tightening and reduces wrinkle; Simultaneously, plant polyphenol still be a kind of have preserve moisture, the natural product of anti-aging effects.Whitening antioxidation cosmetic compositions provided by the invention, by weight percentage, the consumption of Radix Sanguisorbae extract is 0.001-10%, preferred content is 0.05-5%.
In whitening antioxidation cosmetic compositions provided by the invention, except that above-mentioned essential composition, can suitably cooperate the composition that in cosmetics, uses usually as required, for example, matrix components such as other whitening agent, wetting agent, antioxidant, surfactant, alcohols, water.
Whitening antioxidation cosmetic compositions provided by the invention can pass through preparations such as solution, emulsion, suspension.Can be cosmetic water, clarifying lotion, essence, sunscreen cream or facial film etc., but be not limited to above-mentioned dosage form and use form.
Beneficial effect: polygonin can the restraint of tyrosinase activity, melanocyte generates, and also has functions such as the free radical of removing, SOD activity improving, shows good whitening and anti-oxidation function.Whitening antioxidation cosmetic compositions Pear Power skin provided by the invention, crease-resistant wrinkle removal, speckle dispelling, effect such as preserve moisture.
The specific embodiment
The present invention will be described in more detail to enumerate embodiment below, but technical scope of the present invention is not limited by these embodiment, and proportional quantity is a percentage by weight.
Experimental technique and evaluation methodology:
1) mensuration of free radical scavenging effect:
The DPPH solution 2mL that gets liquid 2mL to be measured and concentration and be 100u mol/L successively adds in the same tool plug test tube, shakes up; Left standstill working sample absorbance under the 517nm wavelength under the room temperature 30 minutes.
Suppression ratio: k%=[1-(A
i-A
j)/A
c] * 100%
A
i: the absorbance of 2ml DPPH solution+2ml liquid to be measured
A
j: the absorbance of 2ml liquid to be measured+2ml solvent
A
c: the absorbance of 2ml DPPH solution+2ml solvent
2) superoxide dismutase (Superoxide Dismutase, SOD) detect:
SOD plays crucial effects to the oxidation and the antioxidation balance of body.SOD can remove ultra-oxygen anion free radical, and the protection cell is avoided damage.Test kit adopts xanthine oxidase (hydroxylamine assay) to measure the SOD vigor.Produce ultra-oxygen anion free radical by xanthine and xanthine oxidase response system, latter's oxidation azanol forms nitrite, presents aubergine under the effect of developer, surveys its absorbance with visible spectrophotometer.When containing SOD in the sample, then ultra-oxygen anion free radical there is narrow spectrum inhibitory action, the nitrite of formation is reduced, and the absorbance of measuring pipe during colorimetric is lower than the absorbance of control tube, calculates the SOD vigor that can obtain in the sample by formula.
With the B16 melanocyte with 1 * 10
5The density of individual/mL is inoculated in 6 orifice plates.Every hole 3ml, hatch 24h after, abandon supernatant, add medicine to be measured, behind the drug effect 3d, abandon supernatant, PBS washing, every hole adds 0.5mL trypsin digestion cell 3min, every hole adds 2ml and keeps liquid and stop digestion.Behind the piping and druming mixing, the centrifugal supernatant of abandoning of cell suspension adds ultrasonication in the PBS ice bath.Multigelation 3 times is pressed the test kit operating instruction and is detected the SOD activity.
3) suppress tryrosinase vitality test in the mouse melanin cell:
The B16 melanocyte is inoculated in 96 orifice plates, every hole 100ul, put in the incubator cultivate educate 24h after, add medicine.Behind the drug effect 3d, abandoning supernatant, with pH 6.8 PBS flushing twice, every hole adds the PBS that 90uL contains 1% (volume fraction) TritonX-100.Ultrasonication in the ice bath, every hole adds the L-dopa of 10uL 10m moL/L, hatches 60min for 37 ℃, and in 475nm place colorimetric, each hole absorbance is surveyed in the blank well zeroing.
Suppression ratio=(1-medicine group mean light absorbency value ÷ matched group mean light absorbency value) * 100%.
4) suppress melanocyte synthetic test in the mouse melanin cell
Will be from the B16 melanoma cells of mice with 1 * 10
5The density of individual/mL is inoculated in culture dish, cultivates 2 days under 37 ℃, the condition of 5%CO2.Abandon supernatant, add medicine, behind the drug effect 3d, abandon supernatant, the PBS washing, every hole adds 0.5mL trypsin digestion cell 3min, and every hole adds 2ml and keeps liquid termination digestion.Behind the piping and druming mixing, every kind of concentration is taken out 0.5mL and is done the cell counting.All the other cell suspension are abandoned supernatant with the centrifugal 5min of 2500r/min, add NaOH solution in precipitation, and heating makes the melanin dissolving, and spectrophotometer detects the absorbance of 475nm.
Melanin synthesizes suppression ratio=[1-(medicine hole absorbance ÷ medicine porocyte density) ÷ (control wells absorbance ÷ control wells cell density)] * 100%
Final experimental result:
| The free radical scavenging effect | SOD is active to be improved | The tryrosinase vigor suppresses | Melanocyte is synthetic to be suppressed | |
| Polygonin | 76.4％ | 16.5％ | 46.7％ | 52.3％ |
| Arbutin | 53.8％ | No effect | 21.3％ | 30.5％ |
Experiment shows, polygonin effectively the restraint of tyrosinase activity, suppress melanocyte and generate, have the function of removing free radical and increasing the SOD vigor simultaneously, its effect obviously is better than the whitening agent arbutin used always.
Embodiment 1: astringent
A and B ingredients constitute should be disguised the percentage by weight of water
A: polyoxyethylene (15) lauryl alcohol 0.5
Glycerol 4.0
Ethanol 5.0
Silk peptide 2.0
Polyoxyethylene (80) Arlacel-80 0.4
Antiseptic, essence are an amount of
Triethanolamine 0.1
Card ripple 0.1
B: polygonin 0.10
Radix Sanguisorbae extract 1.00
Preparation: stirring joins A and B component respectively in the deionized water down, stirs evenly to get final product
Embodiment 2: elite is revealed
The percentage by weight that this elite of ingredients constitute is revealed
1,3 butylene glycol 2.00
Glycerol 3.00
Polyoxyethylene (20) oleyl ether 1.30
Ethyl oleate 0.50
Oleyl alcohol 0.40
Citric acid 0.35
Disodium hydrogen phosphate 0.65
Methyl parahydroxybenzoate 0.10
Polygonin 0.10
Radix Sanguisorbae extract 1.00
Preparation: successively said components is added in the deionized water, mix homogeneously gets final product.
Embodiment 3: emollient cream
The percentage by weight of this emollient cream of ingredients constitute
A: 16 octadecanol 7.5
Monoglyceride 2.5
White oil 13.0
Lanoline 0.50
B: glycerol 2.0
Propylene glycol 5.0
Aliphatic acid polyethenoxy (7) ether 2.0
C: antiseptic is an amount of
Essence 0.3
D: polygonin 0.10
Radix Sanguisorbae extract 1.00
Preparation: 1) heating and stirring A to 80C;
2) B is mixed, be heated to 85C;
3) C and D are added in the deionized water;
4) A is joined B, high speed homogenization continues to stir and cooling, adds in the deionized water during to 50C, and stirring gets final product.
Embodiment 4: cleawhite pack
The percentage by weight of this cleawhite pack of ingredients constitute
Polyvinyl alcohol 12.0
Vinyl acetate emulsion 14.0
Propylene glycol 5.0
Polyoxyethylene (60) sorbitan monostearate 0.5
Silicone oil emulsion 1.5
Ethanol 5.0
Polygonin 0.10
Radix Sanguisorbae extract 1.00
Preparation:, join in the deionized water that has mixed polyoxyethylene (60) sorbitan monostearate and silicone emulsion the polyvinyl alcohol moistening with ethanol, be heated to 70 ℃, stir simultaneously, make it mix homogeneously, again other remaining raw material is all added, stir evenly and get final product.
Claims (5)
1, a kind of whitening antioxidation cosmetic compositions is characterized by, and contains polygonin.
2, whitening antioxidation cosmetic compositions according to claim 1 is characterized by, and above-mentioned polygonin weight accounts for the 0.001-10% of said composition gross weight.
3, whitening antioxidation cosmetic compositions according to claim 2 is characterized by, and above-mentioned polygonin weight accounts for the 0.05-1% of said composition gross weight.
4, whitening antioxidation cosmetic compositions according to claim 3 is characterized by, and also contains the Radix Sanguisorbae extract, and this Radix Sanguisorbae extract weight accounts for the 0.01-10% of said composition gross weight.
5, whitening antioxidation cosmetic compositions according to claim 4 is characterized by, and above-mentioned Radix Sanguisorbae extract weight accounts for the 0.05-5% of said composition gross weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101569118A CN101357114A (en) | 2008-09-19 | 2008-09-19 | Whitening antioxidation cosmetic compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101569118A CN101357114A (en) | 2008-09-19 | 2008-09-19 | Whitening antioxidation cosmetic compositions |
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| Publication Number | Publication Date |
|---|---|
| CN101357114A true CN101357114A (en) | 2009-02-04 |
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| CNA2008101569118A Pending CN101357114A (en) | 2008-09-19 | 2008-09-19 | Whitening antioxidation cosmetic compositions |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109833218A (en) * | 2019-04-18 | 2019-06-04 | 北京林业大学 | A kind of polydatin multiple-effect whitening mask and preparation method thereof |
| US10456343B2 (en) | 2017-01-26 | 2019-10-29 | L'oreal | Microemulsion compositions comprising polydatin and method of use |
| EP3435956A4 (en) * | 2016-03-31 | 2020-01-15 | L'Oréal | Photo-stabilized compositions and methods of use |
| CN111228188A (en) * | 2020-04-13 | 2020-06-05 | 北京悠悦百仕科技发展有限公司 | Facial mask with whitening effect and preparation method thereof |
| CN111265423A (en) * | 2020-04-13 | 2020-06-12 | 北京悠悦百仕科技发展有限公司 | Essence with whitening effect and preparation method thereof |
-
2008
- 2008-09-19 CN CNA2008101569118A patent/CN101357114A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3435956A4 (en) * | 2016-03-31 | 2020-01-15 | L'Oréal | Photo-stabilized compositions and methods of use |
| US10695278B2 (en) | 2016-03-31 | 2020-06-30 | L'oreal | Photo-stabilized compositions and methods of use |
| US10456343B2 (en) | 2017-01-26 | 2019-10-29 | L'oreal | Microemulsion compositions comprising polydatin and method of use |
| CN109833218A (en) * | 2019-04-18 | 2019-06-04 | 北京林业大学 | A kind of polydatin multiple-effect whitening mask and preparation method thereof |
| CN111228188A (en) * | 2020-04-13 | 2020-06-05 | 北京悠悦百仕科技发展有限公司 | Facial mask with whitening effect and preparation method thereof |
| CN111265423A (en) * | 2020-04-13 | 2020-06-12 | 北京悠悦百仕科技发展有限公司 | Essence with whitening effect and preparation method thereof |
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Open date: 20090204 |