CL2015002358A1 - Bicyclic compounds. - Google Patents

Bicyclic compounds.

Info

Publication number
CL2015002358A1
CL2015002358A1 CL2015002358A CL2015002358A CL2015002358A1 CL 2015002358 A1 CL2015002358 A1 CL 2015002358A1 CL 2015002358 A CL2015002358 A CL 2015002358A CL 2015002358 A CL2015002358 A CL 2015002358A CL 2015002358 A1 CL2015002358 A1 CL 2015002358A1
Authority
CL
Chile
Prior art keywords
bicyclic compounds
bicyclic
compounds
cyclopentanamine
tetrahydronaphthalen
Prior art date
Application number
CL2015002358A
Other languages
Spanish (es)
Inventor
Marta Dabros
Hai-Yun Xiao
Alaric J Dyckman
Eric J Chan
Daniel Richard Roberts
T G Murali Dhar
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CL2015002358A1 publication Critical patent/CL2015002358A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons
    • C07C25/22—Polycyclic aromatic halogenated hydrocarbons with condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1-metil-3-(6-hexil-5,6,7,8-tetrahidronaftalen-2-il)ciclopentanamina1-methyl-3- (6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl) cyclopentanamine

CL2015002358A 2013-02-21 2015-08-21 Bicyclic compounds. CL2015002358A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361767531P 2013-02-21 2013-02-21

Publications (1)

Publication Number Publication Date
CL2015002358A1 true CL2015002358A1 (en) 2016-02-26

Family

ID=50272738

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002358A CL2015002358A1 (en) 2013-02-21 2015-08-21 Bicyclic compounds.

Country Status (35)

Country Link
US (3) US9115054B2 (en)
EP (1) EP2958888B1 (en)
JP (1) JP6277210B2 (en)
KR (1) KR102242265B1 (en)
CN (1) CN105026362B (en)
AR (1) AR094851A1 (en)
AU (1) AU2014218883B2 (en)
BR (1) BR112015019919A2 (en)
CA (1) CA2902168C (en)
CL (1) CL2015002358A1 (en)
CY (1) CY1118641T1 (en)
DK (1) DK2958888T3 (en)
EA (1) EA025294B1 (en)
ES (1) ES2613262T3 (en)
HK (1) HK1218111A1 (en)
HR (1) HRP20170247T1 (en)
HU (1) HUE031626T2 (en)
IL (1) IL240613B (en)
LT (1) LT2958888T (en)
MA (1) MA38425B1 (en)
MX (1) MX2015010347A (en)
MY (1) MY173990A (en)
PE (1) PE20151746A1 (en)
PH (1) PH12015501793A1 (en)
PL (1) PL2958888T3 (en)
PT (1) PT2958888T (en)
RS (1) RS55703B1 (en)
SG (1) SG11201506408TA (en)
SI (1) SI2958888T1 (en)
SM (1) SMT201700115B (en)
TN (1) TN2015000356A1 (en)
TW (1) TWI613182B (en)
UY (1) UY35338A (en)
WO (1) WO2014130752A2 (en)
ZA (1) ZA201506965B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3022176B8 (en) 2013-07-15 2019-12-25 The Regents of the University of California Azacyclic constrained analogs of fty720
AR101591A1 (en) 2014-08-20 2016-12-28 Bristol Myers Squibb Co REPLACED BICYCLIC COMPOUNDS
JP6853539B2 (en) * 2015-09-24 2021-03-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ Synthetic sphingolipid-like molecules, drugs, methods of synthesizing them, and methods of treatment
JP7029445B2 (en) 2016-09-02 2022-03-03 ブリストル－マイヤーズ スクイブ カンパニー Substituted tricyclic heterocyclic compound
WO2019032632A1 (en) 2017-08-09 2019-02-14 Bristol-Myers Squibb Company Alkylphenyl compounds
US11059784B2 (en) 2017-08-09 2021-07-13 Bristol-Myers Squibb Company Oxime ether compounds
WO2021062168A1 (en) * 2019-09-25 2021-04-01 The Regents Of The University Of California Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200750A (en) 1977-01-07 1980-04-29 Westwood Pharmaceuticals Inc. 4-Substituted imidazo [1,2-a]quinoxalines
US6069143A (en) 1994-12-20 2000-05-30 Smithkline Beecham Corporation Fibrinogen receptor antagonists
WO2003061567A2 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
WO2003062248A2 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists
CA2472715A1 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. Edg receptor agonists
AU2003217764A1 (en) 2002-03-01 2003-09-16 Merck & Co., Inc. Aminoalkylphosphonates and related compounds as edg receptor agonists
AU2003276043A1 (en) 2002-06-17 2003-12-31 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
WO2005000833A1 (en) 2003-05-19 2005-01-06 Irm, Llc Immunosuppressant compounds and compositions
CA2547198A1 (en) 2003-12-17 2005-06-30 Merck & Co., Inc. (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
US7659294B2 (en) 2004-10-22 2010-02-09 Merck & Co., Inc. 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists
KR20070104407A (en) 2005-02-14 2007-10-25 유니버시티 오브 버지니아 페이턴트 파운데이션 Sphingosine 1-phosphate agonists comprising cycloalkanes and 5-membered heterocycles substitued by amino and phenyl groups
AU2006245438A1 (en) 2005-02-18 2006-11-16 Bellus Health (Innodia) Inc. Analogs of 4-hydroxyisoleucine and uses thereof
EP1858889A1 (en) 2005-03-08 2007-11-28 Biota Scientific Management Pty. Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
US7605269B2 (en) 2005-03-23 2009-10-20 Actelion Pharmaceuticals Ltd. Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists
WO2006115188A1 (en) 2005-04-22 2006-11-02 Daiichi Sankyo Company, Limited Heterocyclic compound
US20080306124A1 (en) 2005-06-08 2008-12-11 Rainer Albert Polycyclic Oxadiazoles or I Soxazoles and Their Use as Sip Receptor Ligands
CN101291908A (en) 2005-08-23 2008-10-22 Irm责任有限公司 Immunosuppressant compounds and compositions
BRPI0706365A2 (en) 2006-01-06 2011-03-22 Sepracor Inc CYCLEalkylamines as monoamine reuptake inhibitors
CN101378741A (en) 2006-01-27 2009-03-04 弗吉尼亚大学专利基金会 Method for treatment of neuropathic pain
WO2007088450A2 (en) 2006-02-01 2007-08-09 Pfizer Products Inc. Chromane antagonist of the h-3 receptor
WO2007109330A2 (en) 2006-03-21 2007-09-27 Epix Delaware, Inc. S1p receptor modulating compounds
WO2007111864A2 (en) 2006-03-23 2007-10-04 Merck & Co., Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
PL2003132T3 (en) 2006-04-03 2014-10-31 Astellas Pharma Inc Oxadiazole derivatives as S1P1 agonists
JP2009269819A (en) 2006-08-25 2009-11-19 Asahi Kasei Pharma Kk Amine compound
ES2400163T3 (en) 2006-09-08 2013-04-08 Actelion Pharmaceuticals Ltd. Pyridyl-3-yl derivatives as immunomodulation agents
GB0625648D0 (en) 2006-12-21 2007-01-31 Glaxo Group Ltd Compounds
US8217027B2 (en) 2006-12-21 2012-07-10 Abbott Laboratories Sphingosine-1-phosphate receptor agonist and antagonist compounds
KR20090095659A (en) * 2006-12-21 2009-09-09 아보트 러보러터리즈 Sphingosine-1-phosphate receptor agonist and antagonist compounds
CN101610674A (en) * 2006-12-21 2009-12-23 艾博特公司 Sphingosine-1-phosphate ester receptor stimulating agent and agonist compounds
UA98951C2 (en) 2007-02-02 2012-07-10 Ф. Хоффманн-Ля Рош Аг 2-aminooxazolines and medicament comprising thereof
JP2010521450A (en) 2007-03-16 2010-06-24 アクテリオン ファーマシューティカルズ リミテッド Amino-pyridine derivatives as S1P1 / EDG1 receptor agonists
WO2009043889A2 (en) 2007-10-04 2009-04-09 Merck Serono S.A. Oxadiazole derivatives
CN101970430B (en) 2007-11-01 2013-05-08 埃科特莱茵药品有限公司 Novel pyrimidine derivatives
GB0725105D0 (en) 2007-12-21 2008-01-30 Glaxo Group Ltd Compounds
EP2280933B1 (en) 2008-04-01 2013-07-24 Theravance, Inc. 2 -aminotetralin derivatives as mu opioid receptor antagonists
US9181182B2 (en) 2008-10-17 2015-11-10 Akaal Pharma Pty Ltd S1P receptors modulators
BRPI0923178A2 (en) 2008-12-18 2016-02-16 Merck Serono Sa fused heterocyclic oxadiazole derivatives useful for treating multiple sclerosis
EP2202232A1 (en) 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. 1,2,4-oxadiazole derivatives and their therapeutic use
EP2210890A1 (en) 2009-01-19 2010-07-28 Almirall, S.A. Oxadiazole derivatives as S1P1 receptor agonists
JP2012515788A (en) 2009-01-23 2012-07-12 ブリストル−マイヤーズ スクイブ カンパニー Substituted oxadiazole derivatives as S1P agonists in the treatment of autoimmune and inflammatory diseases
US8354398B2 (en) 2009-01-23 2013-01-15 Bristol-Myers Squibb Company Substituted isoxazole compounds
JP2012515789A (en) 2009-01-23 2012-07-12 ブリストル−マイヤーズ スクイブ カンパニー Pyrazole-1,2,4-oxadiazole derivatives as sphingosine-1-phosphate agonists
MX2011008458A (en) 2009-02-10 2011-09-01 Abbott Lab Methods for preparing s1p receptor agonists and antagonists.
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
KR20130036171A (en) 2009-10-29 2013-04-11 브리스톨-마이어스 스큅 컴퍼니 Tricyclic heterocyclic compounds
WO2011133734A1 (en) 2010-04-23 2011-10-27 Bristol-Myers Squibb Company 4 - (5 - isoxazolyl or 5 - pyrrazolyl -1,2,4- oxadiazol - 3 - yl) -mandelic acid amides as sphingosin- 1 - phosphate 1 rreceptor agonists
CN102260177A (en) 2010-05-25 2011-11-30 中国医学科学院药物研究所 Propylene glycol derivative, preparation method thereof, pharmaceutical composition thereof and application thereof
CN102260178A (en) 2010-05-25 2011-11-30 中国医学科学院药物研究所 Hydroxyl propanediol derivative, its preparation method, its pharmaceutical composition and its purpose
US8822510B2 (en) 2010-07-20 2014-09-02 Bristol-Myers Squibb Company Substituted 3-phenyl-1,2,4-Oxadiazole compounds
US9187437B2 (en) 2010-09-24 2015-11-17 Bristol-Myers Squibb Company Substituted oxadiazole compounds
CN103298807A (en) 2010-11-03 2013-09-11 百时美施贵宝公司 Heterocyclic compounds as S1P1 agonists for the treatment of autoimmune and vascular diseases
US9682078B2 (en) * 2011-03-18 2017-06-20 University Of Virginia Patent Foundation Compositions and methods for tissue engineering and cell based therapies
WO2012147311A1 (en) 2011-04-26 2012-11-01 パナソニック株式会社 Heating system, and heating system control method
GB201107325D0 (en) * 2011-05-04 2011-06-15 Glaxosmithkline Llc Novel compounds
EP2706999B1 (en) 2011-05-13 2019-08-28 Celgene International II Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators
WO2014018891A1 (en) 2012-07-27 2014-01-30 Biogen Idec Ma Inc. Compounds that are s1p modulating agents and/or atx modulating agents

Also Published As

Publication number Publication date
UY35338A (en) 2014-08-29
TN2015000356A1 (en) 2017-01-03
IL240613B (en) 2018-06-28
HK1218111A1 (en) 2017-02-03
LT2958888T (en) 2017-02-10
WO2014130752A3 (en) 2014-10-23
US9359286B2 (en) 2016-06-07
US20160251309A1 (en) 2016-09-01
KR102242265B1 (en) 2021-04-19
HUE031626T2 (en) 2017-07-28
AU2014218883B2 (en) 2017-05-11
MX2015010347A (en) 2015-11-16
HRP20170247T1 (en) 2017-04-07
JP6277210B2 (en) 2018-02-07
ZA201506965B (en) 2017-08-30
TW201444786A (en) 2014-12-01
ES2613262T3 (en) 2017-05-23
MA38425B1 (en) 2019-03-29
JP2016513124A (en) 2016-05-12
MA38425A1 (en) 2017-12-29
BR112015019919A2 (en) 2017-07-18
AU2014218883A1 (en) 2015-10-15
US20150315128A1 (en) 2015-11-05
KR20150119352A (en) 2015-10-23
MY173990A (en) 2020-03-03
US9487481B2 (en) 2016-11-08
CN105026362B (en) 2017-07-14
SMT201700115B (en) 2017-03-08
US20140235591A1 (en) 2014-08-21
RS55703B1 (en) 2017-07-31
PL2958888T3 (en) 2017-07-31
SI2958888T1 (en) 2017-01-31
AR094851A1 (en) 2015-09-02
TWI613182B (en) 2018-02-01
PE20151746A1 (en) 2015-12-02
IL240613A0 (en) 2015-10-29
PT2958888T (en) 2017-02-03
US9115054B2 (en) 2015-08-25
CA2902168A1 (en) 2014-08-28
EA201591409A1 (en) 2015-12-30
CA2902168C (en) 2019-01-08
EP2958888A2 (en) 2015-12-30
DK2958888T3 (en) 2017-03-06
CY1118641T1 (en) 2017-07-12
PH12015501793B1 (en) 2015-11-09
PH12015501793A1 (en) 2015-11-09
SG11201506408TA (en) 2015-09-29
EA025294B1 (en) 2016-12-30
WO2014130752A2 (en) 2014-08-28
CN105026362A (en) 2015-11-04
EP2958888B1 (en) 2016-11-23

Similar Documents

Publication Publication Date Title
PH12016500676A1 (en) Pyrimidine fgfr4 inhibitors
EA201891211A1 (en) CXCR2 INHIBITORS
UY34765A (en) NEW COMPOUNDS.
EA201591750A1 (en) ANTIBODIES AGAINST B7-H4 AND IMMUNOCONJUGATES
CL2015002358A1 (en) Bicyclic compounds.
DK3135668T3 (en) New disubstituted 1,2,4-triazine compound
EA201792612A1 (en) 6-AMINOHINOLIN-3-CARBONITRILES AS COT MODULATORS
CL2016001349A1 (en) Use of benzimidazole-proline derivatives
AR097668A1 (en) COLOR-POLYMER
FR3007636B1 (en) TROCART PERFORANT.
CL2016001488A1 (en) Quinazolin-thf-amines as pde1 inhibitors
UY34677A (en) IMIDAZOPIRIDAZINAS REPLACED
PH12016501183A1 (en) Novel compound for treatment of severe hypoglycemia
PH12016501184A1 (en) Novel compound for treatment of severe hypoglycemia
PH12016501182A1 (en) Novel compound for treatment of severe hypoglycemia
BR112015021575A2 (en) fungicidal composition
UA107468U (en) 25,27-DI- (5-THIO-OCTYLOXES) CALIX [4] AREN-CROWN-6
TN2014000522A1 (en) لوح مدرسي بوجهين
TN2013000364A1 (en) تصميم جديد لطائرة مدنية ذات مقعد واحد و انظمة سلامة متطورة
TN2014000384A1 (en) نظام صوتي ذكي وآمن
TN2014000468A1 (en) اختراع الة للف شباك مراكب الصيد البحري و تسهيل تحويلها من المركب الى رصيف الميناء ثم ارجاعة للمركب بعد القيام بعملية ترقيعها
TN2014000377A1 (en) طائرة كهربائية كاتمة للصوت
UA85094U (en) 4-(3,4,5-trimethoxyphenyl)-2-oxo-5-cyano-1,2,3,4-tetrahydropyridine-6-thiolate n-methylmorpholinium
TN2014000355A1 (en) طريقة مبتكرة لتوفير الاضاءة العامة و المنزلية
UA85088U (en) 4-(1-naphthyl)-2-oxo-5-cyano-1,2,3,4-tetrahydropyridine-6-thiolate n- methylmorpholinium