CL2012003729A1 - Composicion farmaceutica oral que comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, uno o mas rellenos, un desintegrante y un lubricante; proceso de preparacion de la composicion. - Google Patents

Composicion farmaceutica oral que comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, uno o mas rellenos, un desintegrante y un lubricante; proceso de preparacion de la composicion.

Info

Publication number
CL2012003729A1
CL2012003729A1 CL2012003729A CL2012003729A CL2012003729A1 CL 2012003729 A1 CL2012003729 A1 CL 2012003729A1 CL 2012003729 A CL2012003729 A CL 2012003729A CL 2012003729 A CL2012003729 A CL 2012003729A CL 2012003729 A1 CL2012003729 A1 CL 2012003729A1
Authority
CL
Chile
Prior art keywords
benzimidazol
quinolin
piperazin
disintegrant
fluoro
Prior art date
Application number
CL2012003729A
Other languages
English (en)
Inventor
Jeewan Thakur
Zhihui Qiu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2012003729A1 publication Critical patent/CL2012003729A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composición farmacéutica oral que comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, uno o más rellenos, un desintegrante y un lubricante; proceso de preparación de la composición.
CL2012003729A 2010-06-30 2012-12-28 Composicion farmaceutica oral que comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, uno o mas rellenos, un desintegrante y un lubricante; proceso de preparacion de la composicion. CL2012003729A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10168028 2010-06-30

Publications (1)

Publication Number Publication Date
CL2012003729A1 true CL2012003729A1 (es) 2013-04-12

Family

ID=42751565

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012003729A CL2012003729A1 (es) 2010-06-30 2012-12-28 Composicion farmaceutica oral que comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, uno o mas rellenos, un desintegrante y un lubricante; proceso de preparacion de la composicion.

Country Status (37)

Country Link
US (1) US9545402B2 (es)
EP (2) EP2588086B1 (es)
JP (1) JP6043281B2 (es)
KR (2) KR101840182B1 (es)
CN (2) CN106943355B (es)
AR (1) AR081776A1 (es)
AU (1) AU2011273519B2 (es)
BR (1) BR112012033479A8 (es)
CA (1) CA2801826C (es)
CL (1) CL2012003729A1 (es)
CO (1) CO6650354A2 (es)
CR (1) CR20120623A (es)
CU (1) CU20120177A7 (es)
DK (1) DK2588086T3 (es)
DO (1) DOP2012000324A (es)
EA (1) EA026244B1 (es)
EC (1) ECSP13012411A (es)
ES (1) ES2701161T3 (es)
GE (1) GEP20146049B (es)
GT (1) GT201200348A (es)
HU (1) HUE042355T2 (es)
IL (1) IL223799A (es)
MA (1) MA34387B1 (es)
MX (1) MX345404B (es)
MY (2) MY163369A (es)
NI (1) NI201200189A (es)
NZ (1) NZ604055A (es)
PE (1) PE20130481A1 (es)
PL (1) PL2588086T3 (es)
PT (1) PT2588086T (es)
SG (1) SG186182A1 (es)
TN (1) TN2012000574A1 (es)
TR (1) TR201818761T4 (es)
TW (1) TWI583384B (es)
UA (1) UA109659C2 (es)
UY (1) UY33472A (es)
WO (1) WO2012001074A2 (es)

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WO2013063003A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
US20140378422A1 (en) 2012-01-31 2014-12-25 Novartis Ag Combination of a RTK inhibitor with an anti-estrogen and use thereof for the treatment of cancer
US20150202203A1 (en) 2012-07-11 2015-07-23 Novartis Ag Method of Treating Gastrointestinal Stromal Tumors
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
WO2014058785A1 (en) 2012-10-10 2014-04-17 Novartis Ag Combination therapy
EP3482771B1 (en) 2013-03-14 2023-01-18 Société des Produits Nestlé S.A. Manufacture of peanut formulations for oral desensitization
US9492535B2 (en) 2013-03-14 2016-11-15 Aimmune Therapeutics, Inc. Peanut formulations and uses thereof
EP3570093B1 (en) 2013-11-15 2021-09-15 Tangible Science, Inc. Contact lens with a hydrophilic layer
WO2015187736A1 (en) * 2014-06-02 2015-12-10 Allergen Research Corporation Placebo formulations and uses thereof
AU2015360637B2 (en) 2014-12-09 2019-08-22 Tangible Science, Inc. Medical device coating with a biocompatible layer
TWI829098B (zh) 2015-01-02 2024-01-11 美商梅拉洛伊卡公司 細菌組成物
CA2986522A1 (en) * 2015-05-22 2016-12-01 Novartis Ag Pharmaceutical compositions
KR20200083526A (ko) 2017-11-02 2020-07-08 에이뮨 테라퓨틱스, 인코퍼레이티드 경구 면역요법 방법
US11229673B2 (en) 2019-05-10 2022-01-25 Société des Produits Nestlé S.A. Methods for improving the quality of life of a patient with a peanut allergy
US10835531B1 (en) 2019-06-18 2020-11-17 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
US20230302139A1 (en) * 2020-07-31 2023-09-28 University Of Florida Research Foundation, Incorporated Targeted rna degradation allows precision repurposing of protein-targeted small molecule medicines to rna

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5009897A (en) * 1988-06-24 1991-04-23 Abbott Laboratories Pharmaceutical granules and tablets made therefrom
BRPI0113757B1 (pt) 2000-09-11 2017-05-23 Chiron Corp derivados de quinolinona como inibibores de tirosina quinase
EP2573079A3 (en) 2002-08-23 2015-03-11 Novartis AG Benzimidazole quinolinones and uses thereof
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
GB0504203D0 (en) * 2005-03-01 2005-04-06 Novartis Ag Organic compounds
SG154451A1 (en) * 2005-05-23 2009-08-28 Novartis Ag Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1- yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts
WO2007014124A2 (en) * 2005-07-22 2007-02-01 Myriad Genetics, Inc. High drug load formulations and dosage forms
AU2006320591B2 (en) 2005-11-29 2010-06-03 Novartis Ag Formulations of quinolinones
CN101316593B (zh) * 2005-11-29 2012-05-02 诺瓦提斯公司 喹啉酮类的制剂
CL2008000681A1 (es) 2007-03-09 2008-10-24 Novartis Ag Metodo de tratamiento de melanoma mediante el uso de compuestos derivados de 4-amino-5-fluoro-(benzoimidazol sustituido)-1h-quinolin-2-ona.
JP5645667B2 (ja) 2007-11-08 2014-12-24 アムビト ビオスシエンセス コルポラチオン 増殖性疾患を治療するための、N−(5−tert−ブチル−イソキサゾール−3−イル)−N’−{4−[7−(2−モルホリン−4−イル−エトキシ)イミダゾ[2,l−b][l,3]ベンゾチアゾール−2−イル]フェニル}尿素の投与方法
AR070924A1 (es) * 2008-03-19 2010-05-12 Novartis Ag Formas cristalinas y dos formas solvatadas de sales del acido lactico de 4- amino -5- fluoro-3-(5-(4-metilpiperazin-1-il ) -1h- bencimidazol-2-il) quinolin -2-(1h) - ona
EP2108365A1 (en) * 2008-04-09 2009-10-14 LEK Pharmaceuticals d.d. Single dosage pharmaceutical formulation comprising eprosartan mesylate
MA34106B1 (fr) 2010-04-16 2013-03-05 Novartis Ag Combinaison de composés organiques

Also Published As

Publication number Publication date
JP2013530196A (ja) 2013-07-25
ECSP13012411A (es) 2013-03-28
GEP20146049B (en) 2014-02-25
US20130090344A1 (en) 2013-04-11
SG186182A1 (en) 2013-01-30
KR101840182B1 (ko) 2018-03-19
CN106943355A (zh) 2017-07-14
DOP2012000324A (es) 2013-02-28
US9545402B2 (en) 2017-01-17
KR20130091319A (ko) 2013-08-16
AU2011273519B2 (en) 2014-05-15
CN106943355B (zh) 2020-09-01
HUE042355T2 (hu) 2019-06-28
UA109659C2 (xx) 2015-09-25
KR20170139170A (ko) 2017-12-18
MA34387B1 (fr) 2013-07-03
PL2588086T3 (pl) 2019-04-30
PE20130481A1 (es) 2013-05-01
EP2588086A2 (en) 2013-05-08
TW201206903A (en) 2012-02-16
EP2588086B1 (en) 2018-09-12
EA201291410A1 (ru) 2013-05-30
PT2588086T (pt) 2018-12-18
TR201818761T4 (tr) 2019-01-21
AU2011273519A1 (en) 2013-01-31
WO2012001074A3 (en) 2012-03-22
MY163369A (en) 2017-09-15
MX2012015091A (es) 2013-02-12
IL223799A (en) 2017-04-30
CO6650354A2 (es) 2013-04-15
CU20120177A7 (es) 2013-04-19
BR112012033479A8 (pt) 2017-10-31
ES2701161T3 (es) 2019-02-21
EP3446686A1 (en) 2019-02-27
CN103068373A (zh) 2013-04-24
DK2588086T3 (en) 2019-01-07
TN2012000574A1 (en) 2014-04-01
MY177741A (en) 2020-09-23
NI201200189A (es) 2013-12-17
EA026244B1 (ru) 2017-03-31
CA2801826A1 (en) 2012-01-05
BR112012033479A2 (pt) 2016-11-29
GT201200348A (es) 2014-03-14
TWI583384B (zh) 2017-05-21
CR20120623A (es) 2013-02-11
NZ604055A (en) 2015-02-27
WO2012001074A2 (en) 2012-01-05
JP6043281B2 (ja) 2016-12-14
MX345404B (es) 2017-01-30
UY33472A (es) 2012-01-31
AR081776A1 (es) 2012-10-17
CA2801826C (en) 2018-04-10

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