CH553182A - Procede de preparation de 2,2-diaryl-4-(4'-aryl-4'-hydroxypiperidino)-butyramides ou -vateramides. - Google Patents

Procede de preparation de 2,2-diaryl-4-(4'-aryl-4'-hydroxypiperidino)-butyramides ou -vateramides.

Info

Publication number
CH553182A
CH553182A CH771871A CH771871A CH553182A CH 553182 A CH553182 A CH 553182A CH 771871 A CH771871 A CH 771871A CH 771871 A CH771871 A CH 771871A CH 553182 A CH553182 A CH 553182A
Authority
CH
Switzerland
Prior art keywords
vateramides
butyramides
hydroxypiperidino
diaryl
aryl
Prior art date
Application number
CH771871A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CH553182A publication Critical patent/CH553182A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32Oxygen atoms
    • C07D307/33Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64Acyl halides
    • C07C57/76Acyl halides containing halogen outside the carbonyl halide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/115Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/52Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatuses For Generation Of Mechanical Vibrations (AREA)
CH771871A 1970-06-01 1971-05-26 Procede de preparation de 2,2-diaryl-4-(4'-aryl-4'-hydroxypiperidino)-butyramides ou -vateramides. CH553182A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4253070A 1970-06-01 1970-06-01
US12960771A 1971-03-30 1971-03-30

Publications (1)

Publication Number Publication Date
CH553182A true CH553182A (fr) 1974-08-30

Family

ID=26719340

Family Applications (2)

Application Number Title Priority Date Filing Date
CH605872A CH549015A (fr) 1970-06-01 1971-05-26 Procede de preparation de 2,2-diaryl-4-(4'-aryl-4'-hydroxypiperidino)-butyramides ou -valeramides.
CH771871A CH553182A (fr) 1970-06-01 1971-05-26 Procede de preparation de 2,2-diaryl-4-(4'-aryl-4'-hydroxypiperidino)-butyramides ou -vateramides.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH605872A CH549015A (fr) 1970-06-01 1971-05-26 Procede de preparation de 2,2-diaryl-4-(4'-aryl-4'-hydroxypiperidino)-butyramides ou -valeramides.

Country Status (18)

Country Link
JP (1) JPS5754508B1 (fr)
AT (1) AT312606B (fr)
BE (1) BE767798A (fr)
CH (2) CH549015A (fr)
CS (1) CS171232B2 (fr)
DE (2) DE2126559C3 (fr)
DK (1) DK137382B (fr)
ES (1) ES391633A1 (fr)
FI (1) FI54472C (fr)
FR (1) FR2100711B1 (fr)
GB (1) GB1319040A (fr)
HK (1) HK78076A (fr)
HU (1) HU166420B (fr)
IL (1) IL36949A (fr)
NL (1) NL173848C (fr)
NO (1) NO133547C (fr)
PL (1) PL81548B1 (fr)
SE (1) SE369418B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003444A1 (fr) * 1992-08-05 1994-02-17 John Wyeth & Brother Limited Derives d'amides
US5962477A (en) 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5434158A (en) * 1994-04-26 1995-07-18 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin-3 antagonists
GB9502644D0 (en) * 1995-02-10 1995-03-29 Zeneca Ltd Heterocyclic derivatives
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
AU1208397A (en) * 1995-12-28 1997-07-28 Takeda Chemical Industries Ltd. Diphenylmethane derivatives as mip-1alpha/rantes receptor antagonists
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
CN110357808A (zh) * 2019-06-13 2019-10-22 上海上药新亚药业有限公司 一种盐酸洛哌丁胺的结晶工艺

Also Published As

Publication number Publication date
BE767798A (fr) 1971-11-29
CH549015A (fr) 1974-05-15
GB1319040A (en) 1973-05-31
AT312606B (de) 1974-01-10
FR2100711B1 (fr) 1974-09-27
FI54472B (fi) 1978-08-31
SE369418B (fr) 1974-08-26
FR2100711A1 (fr) 1972-03-24
DK137382B (da) 1978-02-27
DE2126559B2 (de) 1981-02-26
DE2126559C3 (de) 1982-01-14
JPS5754508B1 (fr) 1982-11-18
CS171232B2 (en) 1976-10-31
IL36949A (en) 1974-07-31
FI54472C (fi) 1978-12-11
PL81548B1 (en) 1975-08-30
NL173848C (nl) 1984-03-16
DE2126559A1 (de) 1972-10-05
HU166420B (fr) 1975-03-28
NO133547B (fr) 1976-02-09
IL36949A0 (en) 1971-07-28
NO133547C (fr) 1976-05-19
DK137382C (fr) 1978-08-07
NL7106829A (fr) 1971-12-03
HK78076A (en) 1976-12-17
ES391633A1 (es) 1975-09-16
DE2167193C2 (de) 1983-05-19

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Legal Events

Date Code Title Description
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