CA3041340A1 - Anticorps anti-ox40, anticorps anti-gitr, et leurs procedes d'utilisation - Google Patents
Anticorps anti-ox40, anticorps anti-gitr, et leurs procedes d'utilisation Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente divulgation concerne des anticorps qui se lient spécifiquement au récepteur OX40 humain (OX40) et/ou au récepteur GITR humain (GITR), comprenant des anticorps multispécifiques qui se lient, p. ex., à OX40 et GITR, et des compositions les contenant. Les anticorps ci-décrits modulent l'activité OX40 et/ou l'activité GITR, p. ex., améliorent, activent, induisent, réduisent, désactivent ou inhibent l'activité OX40 et/ou GITR. Des méthodes destinées à traiter des troubles, tels que le cancer, des maladies ou troubles auto-immuns, ou des maladies ou troubles inflammatoires, par administration d'un anticorps qui se lie spécifiquement au récepteur OX40 humain et/ou au récepteur GITR humain et module l'activité OX40 et/ou GITR sont en outre décrites.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662419907P | 2016-11-09 | 2016-11-09 | |
| US62/419,907 | 2016-11-09 | ||
| PCT/US2017/060854 WO2018089628A1 (fr) | 2016-11-09 | 2017-11-09 | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3041340A1 true CA3041340A1 (fr) | 2018-05-17 |
Family
ID=62110331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3041340A Pending CA3041340A1 (fr) | 2016-11-09 | 2017-11-09 | Anticorps anti-ox40, anticorps anti-gitr, et leurs procedes d'utilisation |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11359028B2 (fr) |
| EP (1) | EP3538152A4 (fr) |
| AU (1) | AU2017359467A1 (fr) |
| CA (1) | CA3041340A1 (fr) |
| MA (1) | MA46770A (fr) |
| WO (1) | WO2018089628A1 (fr) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3148579T3 (pl) | 2014-05-28 | 2021-07-19 | Agenus Inc. | Przeciwciała anty-gitr i sposoby ich zastosowania |
| WO2016179517A1 (fr) | 2015-05-07 | 2016-11-10 | Agenus Inc. | Anticorps anti-ox40 et procédés d'utilisation de ceux-ci |
| KR20180083944A (ko) | 2015-12-02 | 2018-07-23 | 아게누스 인코포레이티드 | 항체 및 이의 사용 방법 |
| SG10201912563XA (en) | 2016-05-27 | 2020-02-27 | Agenus Inc | Anti-tim-3 antibodies and methods of use thereof |
| CA3041340A1 (fr) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anticorps anti-ox40, anticorps anti-gitr, et leurs procedes d'utilisation |
| BR112020025721A2 (pt) | 2018-07-03 | 2021-04-06 | Gilead Sciences, Inc. | Anticorpos que visam a gp120 do hiv e métodos de uso |
| WO2020014583A1 (fr) | 2018-07-13 | 2020-01-16 | Bristol-Myers Squibb Company | Combinaison d'agoniste d'ox-40, d'inhibiteur de la voie pd-1 et d'inhibiteur ctla-4 destinée à être utilisée dans un procédé de traitement d'un cancer ou d'une tumeur solide |
| US10442866B1 (en) * | 2019-01-23 | 2019-10-15 | Beijing Mabworks Biotech Co. Ltd | Antibodies binding OX40 and uses thereof |
| KR20210125509A (ko) * | 2019-02-01 | 2021-10-18 | 케이에스큐 세러퓨틱스 인코포레이티드 | 개선된 면역요법을 위한 유전자-조절 조성물 및 방법 |
| TW202231277A (zh) | 2019-05-21 | 2022-08-16 | 美商基利科學股份有限公司 | 鑑別對使用gp120 v3聚醣導向之抗體的治療敏感之hiv病患的方法 |
| CR20210687A (es) | 2019-06-25 | 2022-03-03 | Gilead Sciences Inc | PROTEÍNAS DE FUSIÓN FLT3L-Fc Y MÉTODOS DE USO |
| KR20240137107A (ko) | 2019-07-16 | 2024-09-19 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 백신, 및 이의 제조 및 사용 방법 |
| WO2021011891A1 (fr) | 2019-07-18 | 2021-01-21 | Gilead Sciences, Inc. | Formulations à action prolongée de ténofovir alafénamide |
| KR20220074917A (ko) | 2019-09-30 | 2022-06-03 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 백신 및 hbv를 치료하는 방법 |
| KR20220085796A (ko) | 2019-10-18 | 2022-06-22 | 포티 세븐, 인코포레이티드 | 골수이형성 증후군 및 급성 골수성 백혈병을 치료하기 위한 조합 치료 |
| US20210147568A1 (en) | 2019-10-31 | 2021-05-20 | Forty Seven, Inc. | Anti-cd47 based treatment of blood cancer |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| EP4069729A1 (fr) | 2019-12-06 | 2022-10-12 | Precision BioSciences, Inc. | Méganucléases modifiées optimisées ayant une spécificité pour une séquence de reconnaissance dans un génome du virus de l'hépatite b |
| US11845723B2 (en) | 2019-12-24 | 2023-12-19 | Gilead Sciences, Inc. | Diacylglycerol kinase modulating compounds |
| AU2021219668A1 (en) | 2020-02-14 | 2022-08-25 | Gilead Sciences, Inc. | Antibodies and fusion proteins that bind to CCR8 and uses thereof |
| WO2021188959A1 (fr) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Promédicaments de nucléosides de 4'-c-substitué-2-halo-2'-désoxyadénosine et leurs procédés de fabrication et d'utilisation |
| BR112022020769A2 (pt) | 2020-05-01 | 2022-12-20 | Gilead Sciences Inc | Compostos de 2,4-dioxopirimidina de inibição de cd73 |
| WO2021236944A1 (fr) | 2020-05-21 | 2021-11-25 | Gilead Sciences, Inc. | Compositions pharmaceutiques contenant du bictégravir |
| IL299980A (en) | 2020-08-07 | 2023-03-01 | Gilead Sciences Inc | Preparations of phosphonamide nucleotide analogues and their medicinal use |
| CN112043696B (zh) * | 2020-08-26 | 2023-02-24 | 深圳市第二人民医院(深圳市转化医学研究院) | Ido-1抑制剂在制备治疗骨性关节炎药物中的应用 |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| CA3195799A1 (fr) | 2020-11-11 | 2022-05-19 | Stephen R. Martin | Procedes d'identification des patients vih sensibles a la therapie avec des anticorps visant le site de liaison cd4 de la gp120 |
| TW202246334A (zh) | 2021-02-02 | 2022-12-01 | 美商美國禮來大藥廠 | Gitr拮抗劑及其使用方法 |
| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
| CA3217107A1 (fr) | 2021-05-13 | 2022-11-17 | Daniel J. CLOUTIER | Combinaison d'un compose de modulation de tlr8 et agent therapeutique anti-arnsi de vhb |
| US20220389394A1 (en) | 2021-05-18 | 2022-12-08 | Gilead Sciences, Inc. | METHODS OF USING FLT3L-Fc FUSION PROTEINS |
| JP2024522594A (ja) | 2021-06-23 | 2024-06-21 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| IL309378A (en) | 2021-06-23 | 2024-02-01 | Gilead Sciences Inc | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS |
| US11976072B2 (en) | 2021-06-23 | 2024-05-07 | Gilead Sciences, Inc. | Diacylglycerol kinase modulating compounds |
| US11999733B2 (en) | 2021-06-23 | 2024-06-04 | Gilead Sciences, Inc. | Diacylglycerol kinase modulating compounds |
| US20230183216A1 (en) | 2021-10-28 | 2023-06-15 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
| AU2022376954A1 (en) | 2021-10-29 | 2024-05-02 | Gilead Sciences, Inc. | Cd73 compounds |
| AU2022399845A1 (en) | 2021-12-03 | 2024-05-23 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
| KR20240113832A (ko) | 2021-12-03 | 2024-07-23 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 바이러스 감염 치료용 화합물 |
| AU2022401696A1 (en) | 2021-12-03 | 2024-05-09 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
| WO2023107956A1 (fr) | 2021-12-08 | 2023-06-15 | Dragonfly Therapeutics, Inc. | Protéines se liant à nkg2d, cd16 et 5t4 |
| WO2023107954A1 (fr) | 2021-12-08 | 2023-06-15 | Dragonfly Therapeutics, Inc. | Anticorps ciblant 5t4 et leurs utilisations |
| KR20240125012A (ko) | 2021-12-22 | 2024-08-19 | 길리애드 사이언시즈, 인코포레이티드 | 이카로스 아연 핑거 패밀리 분해제 및 이의 용도 |
| KR20240123836A (ko) | 2021-12-22 | 2024-08-14 | 길리애드 사이언시즈, 인코포레이티드 | 이카로스 아연 핑거 패밀리 분해제 및 이의 용도 |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| US20230373950A1 (en) | 2022-03-17 | 2023-11-23 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| WO2023183817A1 (fr) | 2022-03-24 | 2023-09-28 | Gilead Sciences, Inc. | Polythérapie pour le traitement de cancers exprimant trop -2 |
| TW202345901A (zh) | 2022-04-05 | 2023-12-01 | 美商基利科學股份有限公司 | 用於治療結腸直腸癌之組合療法 |
| TWI843506B (zh) | 2022-04-06 | 2024-05-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| IL316058A (en) | 2022-04-21 | 2024-11-01 | Gilead Sciences Inc | Compounds modulate KRAS G12D |
| US20240034724A1 (en) | 2022-07-01 | 2024-02-01 | Gilead Sciences, Inc. | Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection |
| WO2024006929A1 (fr) | 2022-07-01 | 2024-01-04 | Gilead Sciences, Inc. | Composés cd73 |
| WO2024015741A1 (fr) | 2022-07-12 | 2024-01-18 | Gilead Sciences, Inc. | Polypeptides immunogènes du vih et vaccins et utilisations de ceux-ci |
| US20240083984A1 (en) | 2022-08-26 | 2024-03-14 | Gilead Sciences, Inc. | Dosing and scheduling regimen for broadly neutralizing antibodies |
| US20240091351A1 (en) | 2022-09-21 | 2024-03-21 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY |
| WO2024076915A1 (fr) | 2022-10-04 | 2024-04-11 | Gilead Sciences, Inc. | Analogues de 4'-thionucléosides et leur utilisation pharmaceutique |
| WO2024137852A1 (fr) | 2022-12-22 | 2024-06-27 | Gilead Sciences, Inc. | Inhibiteurs de prmt5 et leurs utilisations |
| WO2024215754A1 (fr) | 2023-04-11 | 2024-10-17 | Gilead Sciences, Inc. | Composés modulateurs de kras |
| WO2024220624A1 (fr) | 2023-04-19 | 2024-10-24 | Gilead Sciences, Inc. | Schéma posologique d'inhibiteur de capside |
| WO2024220917A1 (fr) | 2023-04-21 | 2024-10-24 | Gilead Sciences, Inc. | Inhibiteurs de prmt5 et leurs utilisations |
Family Cites Families (194)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0714409A1 (fr) | 1993-06-16 | 1996-06-05 | Celltech Therapeutics Limited | Anticorps |
| WO1995001997A1 (fr) | 1993-07-09 | 1995-01-19 | Smithkline Beecham Corporation | ANTICORPS RECOMBINANTS ET HUMANISES, DIRIGES CONTRE L'IL-1β ET DESTINES AU TRAITEMENT DE TROUBLES INFLAMMATOIRES INDUITS PAR IL-1 CHEZ L'HOMME |
| US5821332A (en) | 1993-11-03 | 1998-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | Receptor on the surface of activated CD4+ T-cells: ACT-4 |
| US5759546A (en) | 1994-02-04 | 1998-06-02 | Weinberg; Andrew D. | Treatment of CD4 T-cell mediated conditions |
| US6242566B1 (en) | 1994-02-10 | 2001-06-05 | Board Of Trustees Of The Leland Stanford Junior University | Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells |
| ATE279947T1 (de) | 1996-03-18 | 2004-11-15 | Univ Texas | Immunglobulinähnliche domäne mit erhöhten halbwertszeiten |
| WO1998023289A1 (fr) | 1996-11-27 | 1998-06-04 | The General Hospital Corporation | Modulation de la fixation de l'igg au fcrn |
| ATE408011T1 (de) | 1998-02-24 | 2008-09-15 | Sisters Of Providence In Orego | Zusammensetzungen, die entweder ein ox-40- rezeptor-bindemittel oder eine für ein solches bindemittel kodierende nukleicsäuresequenz enthalten, und verfahren zur verbesserung der antigenspezifischen immunantwort |
| US6312700B1 (en) | 1998-02-24 | 2001-11-06 | Andrew D. Weinberg | Method for enhancing an antigen specific immune response with OX-40L |
| DE69942037D1 (de) | 1998-12-23 | 2010-04-01 | Amgen Fremont Inc | Humane monoklonale antikörper gegen ctla-4 |
| PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
| US20030035790A1 (en) | 1999-01-15 | 2003-02-20 | Shu-Hsia Chen | Combination therapy for the prevention or treatment of cancer, inflammatory disorders or infectious diseases in a subject |
| ES2282133T3 (es) | 1999-08-24 | 2007-10-16 | Medarex, Inc. | Anticuerpos frente a la ctla-4 humano y sus usos. |
| JP2003531588A (ja) | 2000-04-11 | 2003-10-28 | ジェネンテック・インコーポレーテッド | 多価抗体とその用途 |
| WO2002028440A1 (fr) | 2000-10-02 | 2002-04-11 | The Scripps Research Institute | Procedes et compositions servant a moduler l'activation des lymphocytes t et leurs utilisations |
| ES2649037T3 (es) | 2000-12-12 | 2018-01-09 | Medimmune, Llc | Moléculas con semividas prolongadas, composiciones y usos de las mismas |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20150329617A1 (en) | 2001-03-14 | 2015-11-19 | Dynal Biotech Asa | Novel MHC molecule constructs, and methods of employing these constructs for diagnosis and therapy, and uses of MHC molecules |
| EP1482972A4 (fr) | 2001-11-20 | 2005-11-23 | Seattle Genetics Inc | Traitement des troubles immunologiques au moyen des anticorps anti-cd30 |
| TW200303759A (en) | 2001-11-27 | 2003-09-16 | Schering Corp | Methods for treating cancer |
| US20040009174A1 (en) | 2001-12-18 | 2004-01-15 | Arndt Gregory Martin | Method of treating asthma |
| AUPS054702A0 (en) | 2002-02-14 | 2002-03-07 | Immunaid Pty Ltd | Cancer therapy |
| MXPA04009394A (es) | 2002-03-26 | 2005-01-25 | Inmunex Corp | Metodos para utilizar ligando flt3 en procedimientos de inmunizacion. |
| AR039209A1 (es) | 2002-04-03 | 2005-02-09 | Novartis Ag | Derivados de indolilmaleimida |
| US20030223989A1 (en) | 2002-04-18 | 2003-12-04 | Pluenneke John D. | CD137 agonists to treat patients with IgE-mediated conditions |
| CA2489004C (fr) | 2002-06-13 | 2013-01-08 | Crucell Holland B.V. | Molecules de liaison agonistes capables de se lier au recepteur ox40 humain |
| JP5068931B2 (ja) | 2002-07-12 | 2012-11-07 | ザ ジョンズ ホプキンス ユニバーシティー | 独自のクローン形質のリンパ球受容体に結合する試薬および方法 |
| US7291331B1 (en) | 2002-09-11 | 2007-11-06 | La Jolla Institute For Allergy And Immunology | Methods of treating OX40 medicated recall immune responses |
| EP1578459A3 (fr) | 2002-10-25 | 2005-11-23 | University of Connecticut Health Center | Appareil et methode d'immunotherapie d'un cancer par lyse cellulaire commandee |
| DE10261223A1 (de) | 2002-12-20 | 2004-07-08 | MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH | Steigerung der Immunantwort durch Substanzen, welche die Funktion von Natürlichen Killerzellen beeinflussen |
| EP1578419A4 (fr) | 2002-12-30 | 2008-11-12 | 3M Innovative Properties Co | Complexes immunostimulants |
| GB0303319D0 (en) | 2003-02-13 | 2003-03-19 | Novartis Ag | Organic compounds |
| GB0303663D0 (en) | 2003-02-18 | 2003-03-19 | Lorantis Ltd | Assays and medical treatments |
| US20040197312A1 (en) | 2003-04-02 | 2004-10-07 | Marina Moskalenko | Cytokine-expressing cellular vaccine combinations |
| US7435592B2 (en) | 2003-05-13 | 2008-10-14 | Immunovative Therapies, Ltd. | Compositions for allogeneic cell therapy |
| US7402431B2 (en) | 2004-03-01 | 2008-07-22 | Immunovative Therapies, Ltd. | T-cell therapy formulation |
| CN100509850C (zh) | 2003-05-31 | 2009-07-08 | 麦克罗梅特股份公司 | 用于治疗b细胞相关疾病的包含双特异性抗cd3、抗cd19抗体构建体的药物组合物 |
| ES2391974T3 (es) | 2003-06-13 | 2012-12-03 | Ironwood Pharmaceuticals, Inc. | Procedimientos y composiciones para el tratamiento de trastornos gastrointestinales |
| WO2005049085A1 (fr) | 2003-11-18 | 2005-06-02 | Valeocyte Therapies Llc | Utilisation de complexes solubles pour faciliter l'activation cellulaire |
| ES2303218T3 (es) | 2004-01-19 | 2008-08-01 | Novartis Ag | Derivados de indolilmaleimida. |
| US7592431B2 (en) | 2004-02-26 | 2009-09-22 | Immunovative Therapies, Ltd. | Biodegradable T-cell Activation device |
| WO2005117973A2 (fr) | 2004-05-05 | 2005-12-15 | Merrimack Pharmaceuticals, Inc. | Agents de liaison bispecifiques pour la modulation de l'activite biologique |
| US7323235B2 (en) | 2004-07-20 | 2008-01-29 | Graham Group, Inc. | Multi-strip promotional piece |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| EP1866339B8 (fr) | 2005-03-25 | 2021-12-01 | GITR, Inc. | Molecules de liaison gitr et leurs utilisations |
| HUE029789T2 (en) | 2005-05-06 | 2017-04-28 | Providence Health & Services - Oregon | Trimer OX40 Immunoglobulin Fusion Protein and Methods of Application |
| JP2006345852A (ja) | 2005-06-16 | 2006-12-28 | Virxsys Corp | 抗体複合体 |
| GB0512225D0 (en) | 2005-06-16 | 2005-07-27 | Univ Sheffield | Immunoglobulin molecules |
| CA2617009C (fr) | 2005-07-29 | 2017-02-28 | Providence Health System | Produits de ribosome defectueux dans les blebs (flux salivaires inconscients) et procedes d'utilisation pour stimuler une reponse immunitaire |
| EP1941275B1 (fr) | 2005-09-29 | 2013-07-24 | Medimmune, Inc. | Méthode d'identification d'anticorps spécifiques de membranes longueur d'onde et leurs utilisations pour cibler les cellules précurseurs productrices d'immunoglobuline |
| TWI461436B (zh) | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法 |
| WO2007133290A2 (fr) | 2005-12-16 | 2007-11-22 | Genentech, Inc. | Anticorps anti-ox40l et méthodes correspondantes |
| WO2007084559A2 (fr) | 2006-01-13 | 2007-07-26 | Board Of Regents, The University Of Texas System | Procedes en vue de traiter des pathologies en influencant la signalisation de recepteurs ox40 et procedes de criblage a haut debit en vue d’identifier des substances dans ce but |
| US20110008368A1 (en) | 2006-01-13 | 2011-01-13 | Board Of Regents, The University Of Texas System | Methods of modulating the ox40 receptor to treat cancer |
| WO2007133822A1 (fr) | 2006-01-19 | 2007-11-22 | Genzyme Corporation | Anticorps anti-gitr destinés au traitement du cancer |
| JP2009530391A (ja) | 2006-03-22 | 2009-08-27 | インペリアル・イノベ−ションズ・リミテッド | 免疫系の因子の調節に関連する組成物および方法 |
| WO2007130555A2 (fr) | 2006-05-02 | 2007-11-15 | Providence Health System | Augmentation de la réaction immunitaire au vaccin contre le cancer |
| CA2654317A1 (fr) | 2006-06-12 | 2007-12-21 | Trubion Pharmaceuticals, Inc. | Proteines de liaison monocatenaires polyvalentes dotees d'une fonction d'effecteur |
| US10106619B2 (en) | 2006-10-04 | 2018-10-23 | La Jolla Institute For Allergy And Immunology | Virus vaccination and treatment methods with OX40 agonist compositions |
| EP1914242A1 (fr) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Nouveau anticorps Anti-CD38 pour le traitement du cancer |
| GB0620894D0 (en) | 2006-10-20 | 2006-11-29 | Univ Southampton | Human immune therapies using a CD27 agonist alone or in combination with other immune modulators |
| KR20100014588A (ko) | 2007-02-27 | 2010-02-10 | 제넨테크, 인크. | 길항제 ｏｘ40 항체 및 염증성 및 자가면역 질환의 치료에서의 이의 용도 |
| JP2008278814A (ja) | 2007-05-11 | 2008-11-20 | Igaku Seibutsugaku Kenkyusho:Kk | アゴニスティック抗ヒトｇｉｔｒ抗体による免疫制御の解除とその応用 |
| CA2695309A1 (fr) | 2007-09-07 | 2009-03-12 | Symphogen A/S | Methodes de production recombinante d'anticorps anti-rsv |
| EP2192922A4 (fr) | 2007-09-17 | 2010-09-29 | Univ California | Anticorps monoclonaux humains internalisants ciblant des cellules du cancer de la prostate<i>in situ</i> |
| EP3239178A1 (fr) | 2007-12-14 | 2017-11-01 | Bristol-Myers Squibb Company | Molécules de liaison au récepteur humain ox40 |
| EP2240204A1 (fr) | 2008-02-04 | 2010-10-20 | Medarex, Inc. | Anticorps anti-clta-4 avec blocage réduit de la liaison de ctla-4 à b7 et leurs utilisations |
| WO2009141239A1 (fr) | 2008-05-20 | 2009-11-26 | F. Hoffmann-La Roche Ag | Formulation pharmaceutique comprenant un anticorps contre ox40l, utilisations de celle-ci |
| HUE036813T2 (hu) | 2008-07-08 | 2018-07-30 | Incyte Holdings Corp | 1,2,5-Oxadiazolok mint indolamin-2,3-dioxigenáz inhibitorok |
| EP2337795A2 (fr) | 2008-10-01 | 2011-06-29 | Dako Denmark A/S | Multimères de mhc dans des vaccins et la surveillance immunitaire contre le cancer |
| WO2010054010A1 (fr) | 2008-11-07 | 2010-05-14 | Fabrus Llc | Anticorps anti-dll4 et utilisations associées |
| WO2010056898A2 (fr) | 2008-11-12 | 2010-05-20 | University Of Maryland, Baltimore | Clonage à expression rapide d'anticorps monoclonaux humains de cellules b à mémoire |
| AU2010216152B2 (en) | 2009-02-17 | 2015-05-14 | Ucb Biopharma Sprl | Antibody molecules having specificity for human OX40 |
| EP2412825B8 (fr) | 2009-03-24 | 2018-01-10 | Riken | Marqueurs de cellules souches leucémiques |
| IN2015DN02826A (fr) * | 2009-09-03 | 2015-09-11 | Merck Sharp & Dohme | |
| CN102753195A (zh) | 2009-12-07 | 2012-10-24 | 小利兰·斯坦福大学托管委员会 | 用于增强抗肿瘤抗体疗法的方法 |
| GB201000467D0 (en) | 2010-01-12 | 2010-02-24 | Ucb Pharma Sa | Antibodies |
| EP2542590B2 (fr) | 2010-03-05 | 2020-04-01 | The Johns Hopkins University | Compositions et procédés pour des anticorps et protéines de fusion immunomodulateurs ciblés |
| GB201006096D0 (en) | 2010-04-13 | 2010-05-26 | Alligator Bioscience Ab | Novel compositions and uses thereof |
| US20110256184A1 (en) | 2010-04-14 | 2011-10-20 | Battelle Memorial Institute | Non-ordered Mesoporous Silica Structure for Biomolecule Loading and Release |
| EP2399604A1 (fr) | 2010-06-25 | 2011-12-28 | F. Hoffmann-La Roche AG | Nouvelle formulation d'anticorps |
| US20130224237A1 (en) | 2010-07-20 | 2013-08-29 | University Of Miami | Inhibition of nonsense mediated decay pathways |
| AU2011293558B2 (en) | 2010-08-23 | 2014-07-31 | Board Of Regents, The University Of Texas System | Anti-OX40 antibodies and methods of using the same |
| WO2012064760A2 (fr) | 2010-11-08 | 2012-05-18 | Biovest International, Inc. | Matériels et méthodes pour l'orientation d'une réponse immunitaire vers un épitope |
| ES2617983T3 (es) | 2011-01-10 | 2017-06-20 | Ct Atlantic Ltd. | Terapia de combinación que incluye anticuerpos de unión a antígenos asociados a tumores |
| KR101614195B1 (ko) | 2011-03-29 | 2016-04-20 | 로슈 글리카트 아게 | 항체 Fc 변이체 |
| RU2623161C2 (ru) | 2011-04-15 | 2017-06-22 | Компуджен Лтд. | Полипептиды и полинуклеотиды и их применение для лечения иммунологических нарушений и рака |
| WO2012163769A1 (fr) | 2011-06-03 | 2012-12-06 | Ct Atlantic Ltd. | Anticorps se liant à mage a3 |
| EP2723381A4 (fr) | 2011-06-21 | 2015-03-18 | Univ Johns Hopkins | Rayonnement focalisé pour améliorer les thérapies basées sur l'immunité contre les néoplasmes |
| PT2731677T (pt) | 2011-07-11 | 2018-07-27 | Glenmark Pharmaceuticals Sa | Anticorpos que se ligam com ox40 e suas utilizações |
| JP6094486B2 (ja) | 2011-08-11 | 2017-03-15 | 小野薬品工業株式会社 | Ｐｄ−１アゴニストからなる自己免疫疾患治療剤 |
| AU2012299421B2 (en) | 2011-08-23 | 2016-02-04 | Board Of Regents, The University Of Texas System | Anti-OX40 antibodies and methods of using the same |
| US8920075B2 (en) | 2011-09-01 | 2014-12-30 | Halo Maritime Defense Systems, Inc. | Marine barrier and gate |
| WO2013039954A1 (fr) * | 2011-09-14 | 2013-03-21 | Sanofi | Anticorps anti-gitr |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| WO2013043569A1 (fr) | 2011-09-20 | 2013-03-28 | Vical Incorporated | Immunothérapie combinée à action antitumorale synergique faisant appel à des alloantigènes |
| WO2013049307A2 (fr) | 2011-09-30 | 2013-04-04 | University Of Miami | Développement d'une mémoire immunitaire améliorée par une inhibition de mtor des lymphocytes t ciblée par un aptamère |
| UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
| AU2012335496B2 (en) | 2011-11-11 | 2017-05-11 | Ucb Biopharma Sprl | Albumin binding antibodies and binding fragments thereof |
| US9365496B2 (en) | 2011-11-30 | 2016-06-14 | Ludwig Institute For Cancer Research | iNKT cell modulators and methods of using the same |
| GB201120860D0 (en) | 2011-12-05 | 2012-01-18 | Cambridge Entpr Ltd | Cancer immunotherapy |
| DK2794658T3 (en) | 2011-12-19 | 2017-06-19 | Synimmune Gmbh | BISPECIFIC ANTIBODY MOLECULE |
| AU2013211871B2 (en) | 2012-01-25 | 2017-12-14 | Board Of Regents, The University Of Texas System | Biomarkers and combination therapies using oncolytic virus and immunomodulation |
| BR112014018481A2 (pt) | 2012-02-01 | 2017-07-04 | Compugen Ltd | anticorpo monoclonal ou policlonal ou um fragmento de ligação a antígeno do mesmo, polinucleotídeo, anticorpo monoclonal, vetor, hibridoma, anticorpo, hibridoma 5166-2 e/ou 5166-9, anticorpo ou fragmento de ligação a antígeno, composição farmacêutica, uso do anticorpo ou fragmento de ligação a anticorpo, método para tratar câncer, método para diagnosticar câncer em um indivíduo, anticorpo, método, composição ou uso |
| US9828432B2 (en) | 2012-02-06 | 2017-11-28 | Providence Health & Services—Oregon | Cancer treatment and monitoring methods using OX40 agonists |
| HUE036955T2 (hu) | 2012-02-15 | 2018-08-28 | Novo Nordisk As | Antitestek, amelyek a trigger receptort kötik és blokkolják, amely Myeloid-sejteken-1 (TREM-1) van expresszálva |
| CA2864688C (fr) | 2012-02-22 | 2023-09-05 | The Trustees Of The University Of Pennsylvania | Utilisation de recepteurs d'antigene chimeriques (car) comportant un costimulateur inductible (icos) afin d'ameliorer l'activite antitumoraleet la persistance des car |
| US20150037346A1 (en) | 2012-02-23 | 2015-02-05 | Sloan-Kettering Institute For Cancer Research | Prediction of Responsiveness to Treatment with Immunomodulatory Therapeutics and Method of Monitoring Abscopal Effects During Such Treatment |
| US20150157710A1 (en) | 2012-03-02 | 2015-06-11 | Providence Health & Services-Oregon D/B/A Providence Portland Medical Center | Dual ox40 agonist/il-2 cancer therapy methods |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| US8993614B2 (en) | 2012-03-15 | 2015-03-31 | F. Hoffmann-La Roche Ag | Substituted pyrrolidine-2-carboxamides |
| CN104024276A (zh) | 2012-06-21 | 2014-09-03 | 卡姆普根有限公司 | Lsr抗体及其用于癌症治疗的用途 |
| AU2013293062A1 (en) * | 2012-07-19 | 2014-07-24 | Alethia Biotherapeutics Inc. | Anti-Siglec-15 antibodies |
| JP2015523412A (ja) | 2012-07-30 | 2015-08-13 | ワウ ヒン イェウング，アレックス | 腫瘍細胞、ＧＭ‐ＣＳＦのトランスジェニック発現を伴う腫瘍溶解性ウイルスベクター、および免疫チェックポイントモジュレーターなどの成分の少なくとも２種または全３種の同時投与により作られる生のｉｎｖｉｖｏ腫瘍特異的がんワクチンシステム |
| CN104684928A (zh) | 2012-08-02 | 2015-06-03 | Jn生物科学有限责任公司 | 通过半胱氨酸突变和μ尾端多聚化的抗体或融合蛋白 |
| WO2014121099A1 (fr) | 2013-01-31 | 2014-08-07 | Thomas Jefferson University | Protéine de fusion agoniste des cd40 ox40 et ses utilisations |
| WO2015116178A1 (fr) | 2014-01-31 | 2015-08-06 | Thomas Jefferson University | Protéines de fusion pour la modulation des lymphocytes t régulateurs et effecteurs |
| US9834610B2 (en) | 2013-01-31 | 2017-12-05 | Thomas Jefferson University | Fusion proteins for modulating regulatory and effector T cells |
| EP2958571B1 (fr) | 2013-02-21 | 2024-04-10 | Michele Maio | Agents d'hypométhylation de l'adn pour thérapie anticancéreuse |
| EP2976361B1 (fr) | 2013-03-18 | 2018-07-18 | BiocerOX Products B.V. | Anticorps humanisés (ox40) anti-cd134 et leurs utilisations |
| BR112015024553A2 (pt) | 2013-04-05 | 2017-10-24 | Genentech Inc | anticorpo multiespecífico, anticorpo isolado, ácido nucleico isolado, célula hospedeira, método de produção de anticorpo, imunoconjugado, formulação farmacêutica, uso de anticorpo e método de tratamento de indivíduos com distúrbio |
| EP3021866A4 (fr) | 2013-07-15 | 2017-02-22 | The Board of Trustees of the Leland Stanford Junior University | Utilisations médicales d'agonistes de cd38 |
| PL3021869T3 (pl) | 2013-07-16 | 2020-11-16 | F. Hoffmann-La Roche Ag | Sposoby leczenia nowotworu z użyciem antagonistów wiązania osi PD-1 i inhibitorów TIGIT |
| WO2015013671A1 (fr) * | 2013-07-25 | 2015-01-29 | Cytomx Therapeutics, Inc. | Anticorps multispécifiques, anticorps activables multispécifiques et leurs méthodes d'utilisation |
| AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
| TW201605896A (zh) * | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| US10966998B2 (en) | 2013-09-05 | 2021-04-06 | The Johns Hopkins University | Cancer therapy via a combination of epigenetic modulation and immune modulation |
| SG10201909806SA (en) | 2013-11-04 | 2019-11-28 | Glenmark Pharmaceuticals Sa | Production of t cell retargeting hetero-dimeric immunoglobulins |
| EA201690912A1 (ru) | 2013-11-05 | 2016-10-31 | Когнейт Биосервисис, Инк. | Комбинации ингибиторов контрольных точек и терапевтических средств для лечения рака |
| US20160289645A1 (en) | 2013-11-22 | 2016-10-06 | Dnatrix, Inc. | Adenovirus Expressing Immune Cell Stimulatory Receptor Agonist(s) |
| KR20160099092A (ko) | 2013-12-17 | 2016-08-19 | 제넨테크, 인크. | Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법 |
| CA2934073A1 (fr) | 2013-12-20 | 2015-06-25 | The Broad Institute, Inc. | Polytherapie comprenant un vaccin a base de neoantigenes |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| AU2014372309C1 (en) | 2013-12-24 | 2017-12-14 | Janssen Pharmaceutica Nv | Anti-VISTA antibodies and fragments |
| EP3116535B1 (fr) | 2014-03-12 | 2019-08-07 | CureVac AG | Combinaison de vaccination et d'agonistes de ox40 |
| CN106687125B (zh) | 2014-03-12 | 2021-12-14 | 耶达研究与开发有限公司 | 降低系统性调节性t细胞水平或活性来治疗cns疾病和损伤 |
| EP3122779B1 (fr) | 2014-03-24 | 2019-05-22 | Cancer Research Technology Limited | Anticorps modifiés contenant des domaines d'igg2 modifiés conférant des propriétés agonistes ou antagonistes, et utilisation de ces derniers |
| US9975957B2 (en) | 2014-03-31 | 2018-05-22 | Genentech, Inc. | Anti-OX40 antibodies and methods of use |
| MA40682B1 (fr) | 2014-03-31 | 2020-01-31 | Hoffmann La Roche | Anticorps anti-ox40 et procédés d'utilisation correspondants |
| SG10201808746QA (en) | 2014-04-03 | 2018-11-29 | Augusta University Research Institute Inc | Methods for enhancing the efficacy of a tumor-directed immune response |
| US20170165230A1 (en) | 2014-04-09 | 2017-06-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| US20150307620A1 (en) | 2014-04-16 | 2015-10-29 | University Of Connecticut | Linked immunotherapeutic agonists that costimulate multiple pathways |
| EP2939690A1 (fr) | 2014-04-29 | 2015-11-04 | Medizinische Hochschule Hannover | Vaccins |
| BR112016026299A2 (pt) | 2014-05-13 | 2018-02-20 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno redirecionado à célula t para células tendo função de imunossupressão |
| PL3148579T3 (pl) | 2014-05-28 | 2021-07-19 | Agenus Inc. | Przeciwciała anty-gitr i sposoby ich zastosowania |
| DK3151921T3 (da) * | 2014-06-06 | 2019-12-02 | Bristol Myers Squibb Co | Antistoffer mod glucocorticoid-induceret tumornekrosefaktor- receptorer (gitr) og anvendelser deraf |
| US10449227B2 (en) | 2014-06-27 | 2019-10-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Conjugates for immunotherapy |
| WO2015197874A2 (fr) | 2014-06-27 | 2015-12-30 | Apogenix Gmbh | Combinaison d'inhibition du cd95/cd95l et d'immunothérapie du cancer |
| CN112546230A (zh) | 2014-07-09 | 2021-03-26 | 博笛生物科技有限公司 | 用于治疗癌症的联合治疗组合物和联合治疗方法 |
| SG11201700090RA (en) | 2014-07-18 | 2017-02-27 | Advaxis Inc | Listeria-based immunogenic compositions for eliciting anti-tumor responses |
| WO2016025647A1 (fr) | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Traitement tumoral synergique avec l'il-2, un anticorps thérapeutique, et un vaccin contre le cancer |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| GEP20217331B (en) | 2014-08-19 | 2021-12-10 | Merck Sharp & Dohme Corp Us | Anti-tigit antibodies |
| US11344620B2 (en) | 2014-09-13 | 2022-05-31 | Novartis Ag | Combination therapies |
| MX2017004360A (es) | 2014-10-03 | 2017-06-26 | Novartis Ag | Terapias de combinacion. |
| WO2016054638A1 (fr) | 2014-10-03 | 2016-04-07 | Dana-Farber Cancer Institute, Inc. | Anticorps dirigés contre le récepteur du facteur de nécrose tumorale induit par glucocorticoïdes (gitr) et leurs procédés d'utilisation |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| MX2017004708A (es) | 2014-10-10 | 2017-10-12 | Idera Pharmaceuticals Inc | Tratamiento del cáncer con agonista de tlr9 con inhibidores de punto de control. |
| TW201619200A (zh) | 2014-10-10 | 2016-06-01 | 麥迪紐有限責任公司 | 人類化抗－ｏｘ４０抗體及其用途 |
| WO2016059602A2 (fr) | 2014-10-16 | 2016-04-21 | Glaxo Group Limited | Méthodes de traitement du cancer et compositions associées |
| EP3209382B1 (fr) | 2014-10-24 | 2020-11-25 | Calidi Biotherapeutics, Inc. | Technique d'immunotherapie combinee pour le traitement du cancer |
| DK3209778T3 (da) | 2014-10-24 | 2019-05-27 | Astrazeneca | Kombination |
| JP6829193B2 (ja) | 2014-10-27 | 2021-02-10 | ルプレヒト−カールス−ウニヴェルジテート ハイデルベルクＲｕｐｒｅｃｈｔ−Ｋａｒｌｓ−Ｕｎｉｖｅｒｓｉｔａｅｔ Ｈｅｉｄｅｌｂｅｒｇ | がんを治療するための単独または併用療法におけるｃｃｒ５拮抗剤の使用 |
| EP3215182B1 (fr) | 2014-11-05 | 2023-01-04 | The Regents of The University of California | Immunothérapie d'association |
| RU2017119428A (ru) | 2014-11-06 | 2018-12-06 | Дженентек, Инк. | Комбинированная терапия, включающая применение агонистов, связывающихся с ох40, и ингибиторов tigit |
| RU2017120063A (ru) | 2014-11-11 | 2018-12-13 | Медиммьюн Лимитед | Терапевтические комбинации для лечения неоплазии |
| EA038349B1 (ru) | 2014-11-21 | 2021-08-12 | Бристол-Маерс Сквибб Компани | Антитела, содержащие модифицированные константные участки тяжелой цепи |
| JP2018505911A (ja) | 2014-12-05 | 2018-03-01 | イミュネクスト，インコーポレーテッド | 推定上のｖｉｓｔａ受容体としてのｖｓｉｇ８の同定と、ｖｉｓｔａ／ｖｓｉｇ８調節剤を産生するためのその使用 |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
| EP3233918A1 (fr) | 2014-12-19 | 2017-10-25 | Novartis AG | Polythérapies |
| RU2017125531A (ru) | 2014-12-19 | 2019-01-21 | Дана-Фарбер Кэнсер Инститьют, Инк. | Химерные антигенные рецепторы и способы их применения |
| ES2755527T3 (es) | 2015-01-08 | 2020-04-22 | BioNTech SE | Agentes agonistas de unión al receptor de TNF |
| GB201500319D0 (en) | 2015-01-09 | 2015-02-25 | Agency Science Tech & Res | Anti-PD-L1 antibodies |
| WO2016145030A1 (fr) | 2015-03-11 | 2016-09-15 | Providence Health & Services-Oregon | Compositions et méthodes pour améliorer l'efficacité de traitement du cancer |
| US11219673B2 (en) | 2015-03-25 | 2022-01-11 | The Regents Of The University Of Michigan | Compositions and methods for delivery of biomacromolecule agents |
| WO2016168361A1 (fr) | 2015-04-14 | 2016-10-20 | Polynoma, Llc | Vaccins polyvalents et thérapie de combinaison pour le traitement de mélanome |
| CN107743401B (zh) | 2015-04-17 | 2021-08-24 | 百时美施贵宝公司 | 包含抗pd-1抗体和另外的抗体的组合的组合物 |
| WO2016179517A1 (fr) | 2015-05-07 | 2016-11-10 | Agenus Inc. | Anticorps anti-ox40 et procédés d'utilisation de ceux-ci |
| PT3447075T (pt) | 2015-05-15 | 2023-11-16 | Massachusetts Gen Hospital | Anticorpos antagonistas anti-superfamília de recetores do fator de necrose tumoral |
| US20160347848A1 (en) | 2015-05-28 | 2016-12-01 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
| CA2987410A1 (fr) | 2015-05-29 | 2016-12-08 | Bristol-Myers Squibb Company | Anticorps anti-ox40 et leurs utilisations |
| BR112018006531A2 (pt) | 2015-10-01 | 2018-12-11 | Potenza Therapeutics Inc | proteína isolada de ligação ao antígeno (abp), polinucleotídeo isolado, vetor, célula hospedeira, método para produzir uma proteína isolada de ligação ao antígeno (abp), composição farmacêutica, método para tratar ou prevenir uma doença ou condição num sujeito em necessidade deste, método para modular uma resposta imune num indivíduo em necessidade deste e kit |
| WO2017096276A1 (fr) | 2015-12-02 | 2017-06-08 | Agenus Inc. | Anticorps anti-gitr et procédés d'utilisation associés |
| MA43389A (fr) | 2015-12-02 | 2021-05-12 | Agenus Inc | Anticorps anti-ox40 et leurs procédés d'utilisation |
| KR20180083944A (ko) | 2015-12-02 | 2018-07-23 | 아게누스 인코포레이티드 | 항체 및 이의 사용 방법 |
| CA3007022A1 (fr) | 2015-12-02 | 2017-06-08 | Agenus Inc. | Anticorps anti-gitr et leurs methodes d'utilisation |
| CA3006963A1 (fr) | 2015-12-03 | 2017-06-08 | Ludwig Institute For Cancer Research Ltd. | Anticorps anti-ox40 et leurs procedes d'utilisation |
| PT3429618T (pt) | 2016-03-16 | 2024-04-02 | Amal Therapeutics Sa | Combinação de um modulador de ponto de controlo imunitário e um complexo que compreende um péptido de penetração celular, uma carga e um agonistra peptídico de tlr para utilização em medicina |
| WO2017186928A1 (fr) | 2016-04-29 | 2017-11-02 | Curevac Ag | Arn codant pour un anticorps |
| CA3041340A1 (fr) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anticorps anti-ox40, anticorps anti-gitr, et leurs procedes d'utilisation |
-
2017
- 2017-11-09 CA CA3041340A patent/CA3041340A1/fr active Pending
- 2017-11-09 WO PCT/US2017/060854 patent/WO2018089628A1/fr unknown
- 2017-11-09 EP EP17870170.2A patent/EP3538152A4/fr active Pending
- 2017-11-09 AU AU2017359467A patent/AU2017359467A1/en active Pending
- 2017-11-09 MA MA046770A patent/MA46770A/fr unknown
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2019
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2022
- 2022-05-09 US US17/662,606 patent/US20220380479A1/en active Pending
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|---|---|
| US20220389107A1 (en) | 2022-12-08 |
| US20190367627A1 (en) | 2019-12-05 |
| EP3538152A1 (fr) | 2019-09-18 |
| AU2017359467A1 (en) | 2019-05-02 |
| US11359028B2 (en) | 2022-06-14 |
| US20220380479A1 (en) | 2022-12-01 |
| EP3538152A4 (fr) | 2020-09-30 |
| WO2018089628A1 (fr) | 2018-05-17 |
| MA46770A (fr) | 2019-09-18 |
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