CA2478082C - Utilisations d'anticorps 8h9 monoclonaux - Google Patents
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention concerne une composition renfermant une quantité efficace d'anticorps 8H9 monoclonaux ou d'un dérivé de ceux-ci et un excipient approprié. L'invention concerne une composition pharmaceutique renfermant une quantité efficace d'anticorps 8H9 monoclonaux ou d'un dérivé de ceux-ci et un excipient acceptable sur le plan pharmaceutique. L'invention concerne en outre un anticorps différent de l'anticorps 8H9 monoclonal, renfermant les régions de détermination complémentaires de l'anticorps 8H9 monoclonal ou d'un dérivé de celui-ci et capable de se lier au même antigène que l'anticorps 8H9 monoclonal. L'invention concerne aussi une substance capable d'inhiber de manière compétitive la liaison d'anticorps 8H9 monoclonaux; ainsi un scFv isolé d'anticorps 8H9 monoclonaux ou d'un dérivé de ceux-ci et l'antigène 8H9. L'invention concerne enfin différentes utilisations de l'anticorps 8H9 monoclonal ou de son dérivé.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/097,558 | 2002-03-08 | ||
| US10/097,558 US7737258B2 (en) | 2000-10-18 | 2002-03-08 | Uses of monoclonal antibody 8H9 |
| PCT/US2002/033331 WO2003033670A2 (fr) | 2001-10-17 | 2002-10-17 | Procede de preparation d'anticorps monocatenaires |
| US10/273,762 | 2002-10-17 | ||
| USPCT/US02/33331 | 2002-10-17 | ||
| US10/273,762 US7666424B2 (en) | 2001-10-17 | 2002-10-17 | Methods of preparing and using single chain anti-tumor antibodies |
| PCT/US2003/007004 WO2003075846A2 (fr) | 2002-03-08 | 2003-03-06 | Utilisations d'anticorps 8h9 monoclonaux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2478082A1 CA2478082A1 (fr) | 2003-09-18 |
| CA2478082C true CA2478082C (fr) | 2016-02-02 |
Family
ID=27808456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2478082A Expired - Lifetime CA2478082C (fr) | 2002-03-08 | 2003-03-06 | Utilisations d'anticorps 8h9 monoclonaux |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2003220079A1 (fr) |
| CA (1) | CA2478082C (fr) |
| WO (1) | WO2003075846A2 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8414892B2 (en) | 2000-10-18 | 2013-04-09 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| US7737258B2 (en) | 2000-10-18 | 2010-06-15 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| US8501471B2 (en) | 2000-10-18 | 2013-08-06 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| US7740845B2 (en) | 2000-10-18 | 2010-06-22 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| EP1567556A4 (fr) * | 2002-12-02 | 2006-03-22 | Us Gov Health & Human Serv | Immunotoxine recombinante et son utilisation dans le traitement de tumeurs |
| JP5372500B2 (ja) | 2005-06-17 | 2013-12-18 | トレラクス リクイデーティング トラスト | Ｉｌｔ３結合分子およびその使用 |
| WO2008094176A2 (fr) * | 2006-06-19 | 2008-08-07 | Tolerx, Inc. | Molécules se liant à l'ilt3 et leurs utilisations |
| KR20100014527A (ko) * | 2007-03-22 | 2010-02-10 | 슬로안-케테링인스티튜트퍼캔서리서치 | 단일클론항체 8ｈ9의 용도 |
| CA2826942C (fr) | 2011-02-11 | 2021-08-03 | Memorial Sloan-Kettering Cancer Center | Proteines de liaison a l'antigene specifiques d'un peptide a restriction hla |
| PE20141271A1 (es) | 2011-04-01 | 2014-10-08 | Sloan Kettering Inst Cancer | Anticuerpos tipo receptor de celulas t especificos para un peptido wt1 presentado por hla-a2 |
| US9963509B2 (en) | 2014-12-23 | 2018-05-08 | Full Spectrum Genetics, Inc. | Anti-B7H3 binding compounds and uses thereof |
| US10865245B2 (en) | 2014-12-23 | 2020-12-15 | Full Spectrum Genetics, Inc. | Anti-B7H3 binding compounds and uses thereof |
| US20210251994A1 (en) | 2018-06-15 | 2021-08-19 | Flagship Pioneering Innovations V, Inc. | Increasing immune activity through modulation of postcellular signaling factors |
| WO2020227159A2 (fr) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Métodes de modulation de l'activité immunitaire |
| EP4022313A1 (fr) | 2019-08-30 | 2022-07-06 | Y-Mabs Therapeutics, Inc. | Évaluation immunohistochimique de l'expression de b7-h3 |
| EP4076434A1 (fr) | 2019-12-17 | 2022-10-26 | Flagship Pioneering Innovations V, Inc. | Polythérapies anticancéreuses ayant des inducteurs de désassemblage cellulaire dépendant du fer |
| US20230355804A1 (en) | 2020-06-29 | 2023-11-09 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| KR20230165276A (ko) | 2021-03-31 | 2023-12-05 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 타노트랜스미션 폴리펩티드 및 암의 치료에서의 이의 용도 |
| US20240316104A1 (en) | 2021-06-29 | 2024-09-26 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
-
2003
- 2003-03-06 AU AU2003220079A patent/AU2003220079A1/en not_active Abandoned
- 2003-03-06 CA CA2478082A patent/CA2478082C/fr not_active Expired - Lifetime
- 2003-03-06 WO PCT/US2003/007004 patent/WO2003075846A2/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2478082A1 (fr) | 2003-09-18 |
| WO2003075846A2 (fr) | 2003-09-18 |
| WO2003075846A3 (fr) | 2005-08-11 |
| AU2003220079A8 (en) | 2003-09-22 |
| AU2003220079A1 (en) | 2003-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20150716 |
|
| FZDC | Discontinued application reinstated |
Effective date: 20151110 |
|
| MKEX | Expiry |
Effective date: 20230306 |