CA2450289A1 - Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique - Google Patents

Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique Download PDF

Info

Publication number
CA2450289A1
CA2450289A1 CA002450289A CA2450289A CA2450289A1 CA 2450289 A1 CA2450289 A1 CA 2450289A1 CA 002450289 A CA002450289 A CA 002450289A CA 2450289 A CA2450289 A CA 2450289A CA 2450289 A1 CA2450289 A1 CA 2450289A1
Authority
CA
Canada
Prior art keywords
antibody
medium
inoculum
egfr
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002450289A
Other languages
English (en)
Inventor
Joseph Tarnowski
Daniel Velez
Joel Goldstein
Michael Barry
Diane Blumenthal
Girish Pendse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ImClone LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002450289A priority Critical patent/CA2450289A1/fr
Priority to PCT/US2004/008802 priority patent/WO2004085474A2/fr
Publication of CA2450289A1 publication Critical patent/CA2450289A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CA002450289A 2003-03-20 2003-11-19 Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique Abandoned CA2450289A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002450289A CA2450289A1 (fr) 2003-03-20 2003-11-19 Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique
PCT/US2004/008802 WO2004085474A2 (fr) 2003-03-20 2004-03-22 Procede de production d'un anticorps contre le recepteur du facteur de croissance epidermique

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45632403P 2003-03-20 2003-03-20
US52383603P 2003-11-19 2003-11-19
CA002450289A CA2450289A1 (fr) 2003-03-20 2003-11-19 Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique

Publications (1)

Publication Number Publication Date
CA2450289A1 true CA2450289A1 (fr) 2005-05-19

Family

ID=34753238

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002450289A Abandoned CA2450289A1 (fr) 2003-03-20 2003-11-19 Methode de production d'un anticorps ciblant le recepteur du facteur de croissance epidermique

Country Status (2)

Country Link
CA (1) CA2450289A1 (fr)
WO (1) WO2004085474A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092771A2 (fr) 2001-05-11 2002-11-21 Ludwig Institute For Cancer Research Proteines de liaison specifiques et utilisations associees
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
WO2005077414A1 (fr) * 2004-02-12 2005-08-25 Merck Patent Gmbh Formulations liquides fortement concentrees d'anticorps anti-egfr
DE102007001370A1 (de) 2007-01-09 2008-07-10 Curevac Gmbh RNA-kodierte Antikörper
MX338185B (es) 2007-01-25 2016-04-05 Dana Farber Cancer Inst Inc Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante.
ES2582386T3 (es) 2007-03-01 2016-09-12 Symphogen A/S Composiciones de anticuerpos recombinantes contra el receptor del factor de crecimiento epidérmico
ES2542152T3 (es) 2007-03-15 2015-07-31 Ludwig Institute For Cancer Research Ltd. Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas
WO2008135259A2 (fr) * 2007-05-04 2008-11-13 Glycotope Gmbh Composition de molécules d'anticorps
JP5532486B2 (ja) 2007-08-14 2014-06-25 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Egf受容体を標的とするモノクローナル抗体175ならびにその誘導体および用途
CN102137874B (zh) 2008-08-29 2015-02-18 西福根有限公司 抗表皮生长因子受体的重组抗体组合物
WO2010129276A2 (fr) * 2009-04-27 2010-11-11 Case Western Reserve University Agents de ciblage pyro-glutamate aβ
CA2807552A1 (fr) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Acides nucleiques modifies et leurs procedes d'utilisation
WO2012045075A1 (fr) 2010-10-01 2012-04-05 Jason Schrum Nucléosides, nucléotides et acides nucléiques modifiés et leurs utilisations
US8710200B2 (en) 2011-03-31 2014-04-29 Moderna Therapeutics, Inc. Engineered nucleic acids encoding a modified erythropoietin and their expression
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PT3682905T (pt) 2011-10-03 2022-04-07 Modernatx Inc Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações
SG10201604896TA (en) 2011-12-16 2016-08-30 Moderna Therapeutics Inc Modified nucleoside, nucleotide, and nucleic acid compositions
CA2868996A1 (fr) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Polynucleotides modifies pour la production de proteines
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
HRP20220607T1 (hr) 2012-11-26 2022-06-24 Modernatx, Inc. Terminalno modificirana rna
MX2015010429A (es) * 2013-02-13 2016-05-16 Lab Francais Du Fractionnement Cetuximab con glicosilación modificada y sus usos.
EP2970980B2 (fr) 2013-03-15 2022-07-27 Janssen Biotech, Inc. Procédés de fabrication pour contrôler la teneur en lysine c-terminale, en galactose et en contenu d'acide sialique dans des protéines recombinées
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP3044236A2 (fr) 2013-09-12 2016-07-20 Halozyme, Inc. Anticorps anti-récepteur du facteur de croissance épidermique modifiés et procédés pour les utiliser
WO2015048744A2 (fr) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucléotides codant des polypeptides de modulation immunitaire
WO2015051214A1 (fr) 2013-10-03 2015-04-09 Moderna Therapeutics, Inc. Polynucléotides codant pour un récepteur de lipoprotéines de faible densité
CN105820248A (zh) * 2015-01-07 2016-08-03 上海张江生物技术有限公司 一种新型抗egfr单克隆抗体的制备方法及应用
WO2017161206A1 (fr) 2016-03-16 2017-09-21 Halozyme, Inc. Conjugués contenant des anticorps à activité conditionnelle ou des fragments de liaison à un antigène associés, et procédés d'utilisation
WO2017205465A2 (fr) 2016-05-24 2017-11-30 Griswold Karl Edwin Anticorps et leurs procédés de production

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7247301B2 (en) * 2001-06-13 2007-07-24 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)

Also Published As

Publication number Publication date
WO2004085474A2 (fr) 2004-10-07
WO2004085474A3 (fr) 2004-12-23

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued