CA2361534C - Alpha-conotoxin peptides - Google Patents

Abstract

The invention relates to relatively short peptides (termed .alpha. -conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

Description

TITLE OF THE INVENTION
ALPHA-CONOTOXIN PEPTIDES

This invention was made with Government support under Grant No. P01 GM48677 awarded by the National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Maryland. The United States Government has certain rights in the invention.

BACKGROUND OF THE INVENTION

The invention relates to relatively short peptides (termed a-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
The publications and other materials used herein to illuminate the background of the invention, and in particular, cases to provide additional details respecting the practice, and for convenience are referenced in the following text by author and date and are listed alphabetically by author in the appended bibliography.
The predatory cone snails (Conus) have developed a unique biological strategy.
Their venom contains relatively small peptides that are targeted to various neuromuscular receptors and may be equivalent in their pharmacological diversity to the alkaloids of plants or secondary metabolites of microorganisms. Many of these peptides are among the smallest nucleic acid-encoded translation products having defined conformations, and as such, they are somewhat unusual. Peptides in this size range normally equilibrate among many conformations. Proteins having a fixed conformation are generally much larger.

The cone snails that produce these peptides are a large genus of venomous gastropods comprising approximately 500 species. All cone snail species are predators that inject venom to capture prey, and the spectrum of animals that the genus as a whole can envenomate is broad. A
wide variety of hunting strategies are used, however, every Conus species uses fundamentally the same basic pattern of envenomation.

Several peptides isolated from Conus venoms have been characterized. These include the a-, 4- and c,>-conotoxins which target nicotinic acetylcholine receptors, muscle sodium channels, and neuronal calcium channels, respectively (Olivera et al., 1985).
Conopressins, which are vasopressin analogs, have also been identified (Cruz et al., 1987). In addition, peptides named conantokins have been isolated from Conus geographus and Conus tulipa (Mena et al., 1990; Haack et al., 1990).

The a-conotoxins are small peptides highly specific for neuromuscular junction nicotinic acetylcholine receptors (Gray et al., 1981; Marshall and Harvey, 1990; Blount et al., 1992; Jacobsen et al., 1997) or highly specific for neuronal nicotinic acetylcholine receptors (Fainzilber et al., 1994; Johnson et al., 1995; Cartier et al., 1996; Luo et al., 1998). The a-conotoxins with specificity for neuromuscular junction nicotinic acetylcholine receptors are used as neuromuscular blocking agents for use in conjunction with surgery, as disclosed in U.
S. Patent No. 6,268,473, filed 21 January 2000 (Attorney Docket No. 2314-178.
A) and international patent application publication no. Wo 00/43409, filed 21 January (Attorney Docket No. 2314-138.PCT). Additional uses for a-conotoxins are described in U.S. Patent Nos. 4,447,356 (Olivera et al., 1984); 5,432,155; 5,514,774.

Additional uses for a-conotoxins are described in L.S. Patent 6,265,541, filed December 1998. In this application, a-conotoxins with specificity for neuronal nicotinic acetylcholine receptors are used for treating disorders regulated at neuronal nicotinic acetylcholine receptors. Such disorders include, but are not limited to, cardiovascular disorders, gastric motility disorders, urinary incontinence, nicotine addiction, mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal effective disorder) and small cell lung carcinoma, as well as the localization of small cell lung carcinoma.

It is desired to provide additional a -conotoxin peptides having uses as described herein.

SUMMARY OF THE INVENTION

The invention relates to relatively short peptides (termed a-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

2a More specifically, the present invention is directed to a-conotoxin peptides having the general formula I:

Xaal-Xaa2-Xaa3-Xaa4-Xaa5-Cys-Cys-Xaa6-Xaa7-Xaa8-Xaa9-Cys-Xaalo-Xaal i-Xaal2-Cys-Xaa13 (SEQ ID NO1:), wherein Xaal, is des-Xaal, Ile, Leu or Val;
Xaa2 is des-Xaa2, Ala or Gly; Xaa3 is des-Xaa3, Gly, Trp (D or L), neo-Trp, halo-Trp or any unnatural aromatic amino acid; Xaa4 is des-Xaa4, Asp, Phe, Gly, Ala, Glu,y-carboxy-Glu (Gla) or any unnatural aromatic amino acid; Xaa5 is Glu, Gla, Asp, Ala, Thr, Ser, Gly, Ile, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa6 is Ser, Thr, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa7 is Asp, Glu, Gla, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid;
Xaa8 is Ser, Thr, Asn, Ala, Gly, His, halo-His, Pro or hydroxy-Pro; Xaa9 is Thr, Ser, Ala, Asp, Asn, Pro, hydroxy-Pro, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa10 is Gly, Ser, Thr, Ala, Asn, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid;
Xaaõ is Gln, Leu, His, halo-His, Trp (D or L), halo-Trp, neo-Trp, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid or any unnatural aromatic amino acid; Xaa12 is Asn, His, halo-His, Ile, Leu, Val, Gln, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid;
Xaa13 is des-Xaa,3, Val, Ile, Leu, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid. The C-terminus may contain a free carboxyl group or an amide group. The halo is chlorine, bromine or iodine, preferably iodine for Tyr and His and preferably bromine for Tip. The Cys residues may be in D or L
configuration and may optionally be substituted with homocysteine (D or L). The Tyr residues may be substituted with the 3-hydroxyl or 2-hydroxyl isomers and corresponding O-sulpho- and O-phospho-derivatives. The acidic amino acid residues may be substituted with any synthetic acidic bioisoteric amino acid surrogate, e.g., tetrazolyl derivatives of Gly and Ala.
More specifically, the present invention is directed to a-conotoxin peptides having the general formula II:
Xaa, -Xaa2-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Xaa7-Xaa8-Cys-Xaa9-Xaa, o-Xaa, , -Xaa, 2-Xaa, 3-Xaa14-Cys-Xaa15-Xaa16-Xaa17 (SEQ ID NO:2), wherein Xaa, is des-Xaa,, Asp, Glu or y-carboxy-Glu (Gla); Xaa, is des-Xaa2, Gln, Ala, Asp, Glu, Gla; Xaa3 is des-Xaa3, Gly, Ala, Asp, Glu, Gla, Pro or hydroxy-Pro; Xaa4 is des-Xaa4, Gly, Glu, Gla, Gln, Asp, Asn, Pro or hydroxy-Pro; Xaa5 is Ser, Thr, Gly, Glu, Gla, Asn, Trp (D or L), neo-Trp, halo-Trp, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa6 is Asp, Asn, His, halo-His, Thr, Ser, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa7 is Pro or hydroxy-Pro; Xaa8 is Ala, Ser, Thr, Asp, Val, Ile, Pro, hydroxy-Pro, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaag is Gly, Ile, Leu, Val, Ala, Thr, Ser, Pro, hydroxy-Pro, Phe, Tip (D or L), neo-Trp, halo-Trp, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid or any unnatural aromatic amino acid;
Xaa10 is Ala, Asn, Phe, Pro, hydroxy-Pro, Glu, Gla, Gln, His, halo-His, Val, Ser, Thr, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaaõ

is Thr, Ser, His, halo-His, Leu, Ile, Val, Asn, Met, Pro, hydroxy-Pro, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa12 is Asn, Pro, hydroxy-Pro, Gln, Ser, Thr, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys N,N,N-trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa13 is des-Xaa13, Gly, Thr, Ser, Pro, hydroxy-Pro, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa14 is des-Xaa14, Ile, Val, Asp, Leu, Phe, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; and Xaa15 is des-Xaa15, Gly, Ala, Met, Ser, Thr, Tip (D or L), neo-Trp, halo-Tip, any unnatural aromatic amino acid, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa16 is des-Xaa16, Trp (D or L), neo-Trp, halo-Trp, any unnatural aromatic amino acid, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa17 is des-Xaa17, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid. The C-terminus may contain a free carboxyl group or an amide group. The halo is preferably bromine, chlorine or iodine, more preferably iodine for His or Tyr and bromine for Tip. The Cys residues may be in D or L

configuration and may optionally be substituted with homocysteine (D or L).
The Tyr residues may be substituted with the 3-hydroxyl or 2-hydroxyl isomers and corresponding O-sulpho- and 0-phospho-derivatives. The acidic amino acid residues may be substituted with any synthetic acidic bioisoteric amino acid surrogate, e.g., tetrazolyl derivatives of Gly and Ala.
More specifically, the present invention is directed to a-conotoxin peptides having the general formula III:

5 Xaa,-Xaa2-Xaa3-Xaa4-Xaa5-Cys-Cys-Xaa6-Xaa7-Xaa8-Xaa9-Cys-Xaa10-Xaa11-Xaa,2-Xaa,3-Xaa14-Xaa15-Xaa16-Cys-Xaa17-Xaa18-Xaa19-Xaa20-Xaa21-Xaa22-Xaa23-Xaa24 (SEQ ID
NO:3), wherein Xaa1 is des-Xaa1, Ser or Thr; Xaa2 is des-Xaa2, Asp, Glu, y-carboxy-Glu (Gla), Asn, Ser or Thr;
Xaa3 is des-Xaa3, Ala, Gly, Asn, Ser, Thr, Pro, hydroxy-Pro, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa4 is des-Xaa4, Ala, Val, Leu, Ile, Gly, Glu, Gla, Gln, Asp, Asn, Phe, Pro, hydroxy-Pro or any unnatural aromatic amino acid; Xaa5 is des-Xaa5, Thr, Ser, Asp, Glu, Gla, Gin, Gly, Val, Asp, Asn, Ala, Pro, hydroxy-Pro, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa6 is Thr, Ser, Asp, Asn, Met, Val, Ala, Gly, Leu, Ile, Phe, any unnatural aromatic amino acid, Pro, hydroxy-Pro, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa7 is Ile, Leu, Val, Ser, Thr,. Gln, Asn, Asp, Arg, His, halo-His, Phe, any unnatural aromatic amino acid, homoarginine, ornithine, Lys, N-methyl-Lys, NN-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa8 is Pro, hyroxy-Pro, Ser, Thr, Ile, Asp, Leu, Val, Gly, Ala, Phe, any unnatural aromatic amino acid, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa9 is Val, Ala, Gly, Ile, Leu, Asp, Ser, Thr, Pro, hydroxy-Pro, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa10 is His, halo-His, Arg, homoarginine, ornithine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid, Asn, Ala, Ser, Thr, Phe, Ile, Leu, Gly, Trp (D or L), neo-Trp, halo-Trp, any unnatural aromatic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa11 is Leu, Gln, Val, Ile, Gly, Met, Ala, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, Ser, Thr, Arg, homoarginine, ornithine, any unnatural basic amino acid, Asn, Glu, Gla, Gln, Phe, Trp (D or L), neo-Trp, halo-Trp or any unnatural aromatic amino acid; Xaa12 is Glu, Gla, Gln, Asn, Asp, Pro, hydroxy-Pro, Ser, Gly, Thr, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, Arg, homoarginine, ornithine, any unnatural basic amino acid, Phe, His, halo-His, any unnatural aromatic amino acid, Leu, Met, Gly, Ala, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid;
Xaa13 is His, halo-His, Asn, Thr, Ser, Ile, Val, Leu, Phe, any unnatural aromatic amino acid, Arg, homoarginine, ornithine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Try, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa14 is Ser, Thr, Ala, Gin, Pro, hydroxy-Pro, Gly, Ile, Leu, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa15 is Asn, Glu, Gla, Asp, Gly, His, halo-His, Ala, Leu, Gln, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid;
Xaa16 is Met, Ile, Thr, Ser, Val, Leu, Pro, hydroxy-Pro, Phe, any unnatural aromatic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr, any unnatural hydroxy containing amino acid, Glu, Gla, Ala, His, halo-His, Arg, omithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa17 is des-Xaa17, Gly, Asp, Asn, Ala, Ile, Leu, Ser, Thr, His, halo-His, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa, 8 is des-Xaa18, Gly, Glu, Gla, Gln, Trp (D or L), neo, halo-Trp, any unnatural aromatic amino acid, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa19 is des-Xaa19, Ser, Thr, Val, Ile, Ala, Arg, omithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid;
Xaa20 is des-Xaa20, Val, Asp, His, halo-His, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa21 is des-Xaa,1, Asn, Pro or hydroxy-Pro; Xaa22 is des-Xaa22, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa23 is des-Xaa23, Ser or Thr; Xaa24 is des-Xaa24, Leu, Ile or Val; with the proviso that (a) Xaa5 is not Gly, when Xaa1 is des-Xaa1, Xaa2 is des-Xaa2, Xaa3 is des-Xaa3, Xaa4 is des-Xaa4, Xaa6 is Ser, Xaa7 is His, Xaa8 is Pro, Xaa9 is Ala, Xaa10 is Ser, Xaa11 is Val, Xaa12 is Asn, Xaa13 is Asn, Xaa14 is Pro, Xaa15 is Asp, Xaa16 is Ile, Xaa17 is des-Xaa17, Xaa18 is des-Xaa18, Xaa19 is des-Xaa19, Xaa20 is des-Xaa20, Xaa,l is des-Xaa71, Xaa2, is des-Xaa22, Xaa23 is des-Xaa23, and Xaa24 is des-Xaa24. The C-terminus may contain a free carboxyl group or an amide group. The halo is preferably bromine, chlorine or iodine, more preferably iodine for His and Tyr and bromine for Trp. The Cys residues may be in D or L
configuration and may optionally be substituted with homocysteine (D or L). The Tyr residues may be substituted with the 3-hydroxyl or 2-hydroxyl isomers and corresponding O-sulpho- and 0-phospho-derivatives. The acidic amino acid residues may be substituted with any synthetic acidic bioisoteric amino acid surrogate, e.g., tetrazolyl derivatives of Gly and Ala.

The present invention is also directed to novel specific a-conotoxin peptides of general formula I having the formulas:

Asp-Xaa,-Cys-Cys-Ser-Asp-Ser-Arg-Cys-Gly-Xaa2-Asn-Cys-Leu (SEQ ID NO:4);
Ala-Cys-Cys-Ser-Asp-Arg-Arg-Cys-Arg-Xaa3-Arg-Cys (SEQ ID NO:5);
Phe-Thr-Cys-Cys-Arg-Arg-Gly-Thr-Cys-Ser-Gln-His-Cys (SEQ ID NO:6);

Asp-Xaa4-Cys-Cys-Arg-Arg-His-Ala-Cys-Thr-Leu-Ile-Cys (SEQ ID NO:7);
Asp-Xaa4-Cys-Cys-Arg-Xaa5-Xaa5-Cys-Thr-Leu-Ile-Cys (SEQ ID NO:8);
Gly-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Arg-Xaa4-Arg-Cys-Arg (SEQ ID NO:9);
Gly-Gly-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Ala-Xaa3-Arg-Cys (SEQ ID NO:10);
Ile-Ala-Xaa3-Asp-Ile-Cys-Cys-Ser-Xaa,-Xaa5-Asp-Cys-Asn-His-Xaa2-Cys-Val (SEQ
ID
NO: 11); and Gly-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Xaa2-His-Gln-Cys (SEQ ID NO:12), wherein Xaa, is Glu or y-carboxy-Glu (Gla); Xaa2 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys; Xaa3 is Trp (D or L), halo-Trp or neo-Trp; Xaa4 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr; and Xaa5 is Pro or hydroxy-Pro; and the C-terminus contains a carboxyl or amide group. The halo is preferably bromine, chlorine or iodine, more preferably iodine for Tyr and bromine for Trp. In addition, the His residues may be substituted with halo-His; the Arg residues may be substituted by Lys, ornithine, homoargine, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; the Lys residues may be substituted by Arg, ornithine, homoargine, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; the Tyr residues may be substituted with any unnatural hydroxy containing amino acid; the Ser residues may be substituted with Thr; the Thr residues may be substituted with Ser; and the Phe and Trp residues may be substituted with any unnatural aromatic amino acid. The Cys residues may be in D or L configuration and may optionally be substituted with homocysteine (D or L). The Tyr residues may be substituted with the 3-hydroxyl or 2-hydroxyl isomers and corresponding O-sulpho- and 0-phospho-derivatives. The acidic amino acid residues may be substituted with any synthetic acidic bioisoteric amino acid surrogate, e.g., tetrazolyl derivatives of Gly and Ala.

8 More specifically, the present invention is directed to the following a-conotoxin peptides of general formula I:
Iml.l : SEQ ID NO:4, wherein Xaa, is Glu and Xaa, is Lys;
Iml.2: SEQ ID NO:5, wherein Xaa3 is Trp;

Rgl.2: SEQ ID NO:6;
Rg 1.6: SEQ ID NO:7, wherein Xaa4 is Tyr;
Rgl.6A: SEQ ID NO:8, wherein Xaa4 is Tyr and Xaa5 is Pro;
Rg 1.7: SEQ ID NO:9, wherein Xaa4 is Tyr and Xaa5 is Pro;
Rgl.9: SEQ ID NO:10, wherein Xaa3 is Trp and Xaa5 is Pro;
Rgl.10: SEQ ID NO:11, wherein Xaa, is Glu, Xaa2 is Lys, Xaa3 is Trp and Xaa5 is Pro; and Rg1.11: SEQ ID NO:12, wherein Xaa2 is Lys and Xaa5 is Pro.
The C-terminus of Im 1.1, Rg 1.7 an Rg 1.10 preferably contains a free carboxyl group. The C-terminus of Iml.2, Rgl.2, Rgl.6, Rg l .6A, Rgl.9 and Rg 1.11 preferably contains an amide group.
The present invention is further directed to novel specific a-conotoxin peptides of general formula II having the formulas:
Cys-Cys-Ser-Asp-Xaa5-Ala-Cys-Xaa2-Gln-Thr-Xaa5-Gly-Cys-Arg (SEQ ID NO: 13);
Cys-Cys-Xaa,-Asn-Xaa5-Ala-Cys-Arg-His-Thr-Gln-Gly-Cys (SEQ ID NO: 14);
Gly-Cys-Cys-Xaa3-His-Xaa5-Ala-Cys-Gly-Arg-His-Xaa4-CYS (SEQ ID NO: 15);
Ala-Xaa5-Cys-Cys-Asn-Asn-Xaa5-Ala-Cys-Val-Xaa2-His-Arg-Cys (SEQ ID NO: 16);
Ala-Xaa5-Gly-Cys-Cys-Asn-Asn-Xaa5-Ala-Cys-Val-Xaa2-His-Arg-Cys (SEQ ID NO:
17);
Xaa5-Xaa5-Cys-Cys-Asn-Asn-Xaa5-Ala-Cys-Val-Xaa2-His-Arg-Cys (SEQ ID NO:18);
Asp-Xaa,-Asn-Cys-Cys-Xaa3-Asn-Xaa5-Ser-Cys-Xaa5-Arg-Xaa5-Arg-Cys-Thr (SEQ ID
NO:19);
Gly-Cys-Cys-Ser-Thr-Xaa5-Xaa5-Cys-Ala-Val-Leu-Xaa4-Cys (SEQ ID NO:20);
Gly-Cys-Cys-Gly-Asn-Xaa5-Asp-Cys-Thr-Ser-His-Ser-Cys (SEQ ID NO:21);
Gly-Cys-Cys-Ser-Asn-Xaa5-Xaa5-Cys-Ala-His-Asn-Asn-Xaa5-Asp-Cys-Arg (SEQ ID
NO:42);
Gly-Cys-Cys-Xaa4-Asn-Xaa5-Val-Cys-Xaa2-Xaa,-Xaa4-Xaa4-Cys-Xaa3-Xaa, (SEQ ID
NO:154);
Xaa6-Xaa,-Xaa5-Gly-Cys-Cys-Arg-His-Xaa5-Ala-Cys-Gly-Xaa2-Asn-Arg-Cys (SEQ ID
NO:155);

Cys-Cys-Ala-Asp-Xaa5-Asp-Cys-Arg-Phe-Arg-Xaa5-Gly-Cys (SEQ ID NO:156);
Gly-Cys-Cys-Xaa4 Asn-Xaa5-Ser-Cys-Xaa3-Xaa5-Xaaz Thr-Xaa4-Cys-Ser-Xaa3-Xaa2 (SEQ
ID NO:157);
Cys-Cys-Ser-Asn-Xaa5-Thr-Cys-Xaa2-Xaal-Thr-Xaa4-Gly-Cys (SEQ ID NO: 158);
Cys-Cys-Ala-Asn-Xaa5-Ile-Cys-Xaa2-Asn-Thr-Xaa5-Gly-Cys (SEQ ID NO: 159);
Cys-Cys-Asn-Asn-Xaa5-Thr-Cys-Xaa2-Xaa,-Thr-Xaa4-Gly-Cys (SEQ ID NO:160);
Cys-Cys-Ser-Asn-Xaa5-Val-Cys-Xaa2-Xaa,-Thr-Xaa4-Gly-Cys (SEQ ID NO: 161);
Gly-Gly-Cys-Cys-Ser-Xaa4-Xaa5-Xaa5-Cys-Ile-Ala-Ser-Asn-Xaa5-Xaa2-Cys-Gly (SEQ
ID

NO:162);
Gly-Cys-Cys-Ser-His-Xaa5-Val-Cys-Ser-Ala-Met-Ser-Xaa5-Ile-Cys (SEQ ID NO:
163);
Gly-Cys-Cys-Xaa2-Asn-Xaa5-Xaa4-Cys-Gly-Ala-Ser-Xaa2-Thr-Xaa4-Cys (SEQ ID NO:
164);
Gly-Cys-Cys-Ser-Xaa4-Xaa5-Xaa5-Cys-Phe-Ala-Thr-Asn-Xaa5-Asp-Cys (SEQ ID
NO:165);
Gly-Gly-Cys-Cys-Ser-Xaa4-Xaa5-Xaa5-Cys-Ile-Ala-Asn-Asn-Xaa5-Leu-Cys-Ala (SEQ
ID
NO:166);
Gly-Gly-Cys-Cys-Ser-Xaa4-Xaa5-Xaa5-Cys-Ile-Ala-Asn-Asn-Xaa5-Phe-Cys-Ala (SEQ
ID
NO:167);
Asp-Cys-Cys-Ser-Asn-Xaa5-Xaa5-Cys-Ser-Gln-Asn-Asn-Xaa5-Asp-Cys-Met (SEQ ID
NO:168); and Asp-Cys-Cys-Ser-Asn-Xaa5-Xaa5-Cys-Ala-His-Asn-Asn-Xaa5-Asp-Cys-Arg (SEQ ID
NO:169), wherein Xaa, is Glu or y-carboxy-Glu (Gla); Xaa2 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys; Xaa3 is Trp (D or L), halo-Trp or neo-Trp; Xaa4 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr; and Xaa5 is Pro or hydroxy-Pro; and the C-terminus contains a carboxyl or amide group. The halo is preferably bromine, chlorine or iodine, more preferably iodine for Tyr and bromine for Trp. In addition, the His residues may be substituted with halo-His; the Arg residues may be substituted by Lys, ornithine, homoargine, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; the Lys residues may be substituted by Arg, ornithine, homoargine, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; the Tyr residues may be substituted with any unnatural hydroxy containing amino acid; the Ser residues may be substituted with Thr; the Thr residues may be substituted with Ser; and the Phe and Trp residues may be substituted with any unnatural aromatic amino acid. The Cys residues may be in D or L configuration and may optionally be substituted with homocysteine (D or L). The Tyr residues may be substituted with the 3-hydroxyl or 2-hydroxyl isomers and corresponding O-sulpho- and O-phospho-derivatives. The acidic amino acid residues may be substituted with any synthetic acidic bioisoteric amino acid surrogate, e.g., tetrazolyl derivatives of Gly and Ala.
5 More specifically, the present invention is directed to the following a-conotoxin peptides of general formula II:
Snl.l : SEQ ID NO: 13, wherein Xaa2 is Lys and Xaa5 is Pro;
Sn1.2: SEQ ID NO: 14, wherein Xaa, is Glu and Xaa5 is Pro;

Sl1.3: SEQ ID NO: 15, wherein Xaa3 is Trp, Xaa4 is Tyr and Xaa5 is Pro;

10 A1.2: SEQ ID NO:16, wherein Xaa2 is Lys and Xaa5 is Pro;

Bul.l : SEQ ID NO: 17, wherein Xaa2 is Lys and Xaa5 is Pro;
Bul.2: SEQ ID NO:18, wherein Xaa2 is Lys and Xaa5 is Pro;

Bul.3: SEQ ID NO: 19, wherein Xaa, is Glu, Xaa3 is Trp and Xaa5 is Pro;
Bul.4: SEQ ID NO:20, wherein Xaa4 is Tyr and Xaa5 is Pro ;

Cr1.3: SEQ ID NO:21, wherein Xaa5 is Pro;
Di 1.1: SEQ ID NO:42 wherein Xaa5 is Pro;
Msl.7: SEQ ID NO: 154, wherein Xaa2 is Lys, Xaa3 is Trp, Xaa4 is Tyr and Xaa5 is Pro;
P1.7: SEQ ID NO:155, wherein Xaa, is Glu, Xaa2 is Lys, Xaa5 is Pro and Xaa6 is Gln;
Msl.2: SEQ ID NO:156, wherein Xaa5 is Pro;
Msl.3: SEQ ID NO: 157, wherein Xaa2 is Lys, Xaa3 is Trp, Xaa4 is Tyr and Xaa5 is Pro;
Msl.4: SEQ ID NO:158, wherein Xaa1 is Glu, Xaa2 is Lys, Xaa4 is Tyr and Xaa5 is Pro;
Msl.5: SEQ ID NO:159, wherein Xaa2 is Lys and Xaa5 is Pro;

Msl.8: SEQ ID NO: 160, wherein Xaa1 is Glu, Xaa2 is Lys, Xaa4 is Tyr and Xaa5 is Pro;
Msl.9: SEQ ID NO:161, wherein Xaa, is Glu, Xaa2 is Lys, Xaa4 is Tyr and Xaa5 is Pro;
Btl.7: SEQ ID NO:162, wherein Xaa2 is Lys, Xaa4 is Tyr and Xaa5 is Pro;
Lvl.5: SEQ ID NO:163, wherein Xaa5 is Pro;

Ms1.10: SEQ ID NO:164, wherein Xaa2 is Lys, Xaa4 is Tyr and Xaa5 is Pro;
Oml.1: SEQ ID NO:165, wherein Xaa4 is Tyr and Xaa5 is Pro;

R1.6: SEQ ID NO:166, wherein Xaa4 is Tyr and Xaa5 is Pro;
R1.7: SEQ ID NO:167, wherein Xaa4 is Tyr and Xaa5 is Pro;
Vrl.1: SEQ ID NO: 168, wherein Xaa5 is Pro; and Vrl.2: SEQ ID NO:169, wherein Xaa5 is Pro.

The C-terminus preferably contains a carboxyl group for the peptides Snl.l, Snl.2, Cr1.3, Dil.l, Msl.2, Msl.4, Msl.5, Msl.8, Msl.9, Vrl.1 and Vrl.2. The C-terminus of the other peptides preferably contains an amide group.
The present invention is also directed to novel specific a-conotoxin peptides of general formula III having the formulas:
Gly-Cys-Cys-Ser-Asn-Xaa5-V al-Cys-His-L eu-Xaa, -His-Ser-Asn-Met-Cys (SEQ ID
NO:22);
Gly-Cys-Cys-Ser-Asn-Xaa5-Val-Cys-Arg-Gln-Asn-Asn-Ala-Xaa,-Xaa4-Cys-Arg (SEQ ID
NO:23);
Xaa5-Gln-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asp-His-Xaa5-Xaa,-Ile-Cys-Arg (SEQ
ID NO:24);
Xaa5-Xaa,-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asp-His-Xaa5-Xaa,-Ile-Cys-Arg (SEQ
ID NO:25);

Xaa5-Gln-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asp-His-Xaa5-Xaa,-Ile-Cys-Asp (SEQ
ID NO:26);
Xaa5-Arg-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asp-His-Xaa5-Xaa,-Ile-Cys-Arg (SEQ
ID NO:27);
Xaa5-Gln-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asp-His-Xaa5-Gly-Ile-Cys-Arg (SEQ
ID NO:28);
Xaa5-Gln-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asp-His-Xaa5-Xaa,-Thr-Cys-Arg (SEQ
ID NO:29);
Xaa5-Gln-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asp-His-Xaa5-Xaa,-Val-Cys-Arg (SEQ
ID NO:30);
Xaa5-Gln-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Ile-Asp-His-Xaa5-Xaa,-Ile-Cys-Arg (SEQ
ID NO:31);
Xaa5-Gln-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-V al-Asp-His-Xaa5-Xaa, -Ile-Cys-Arg-Arg-Arg-Arg (SEQ ID NO:32);

Gly-Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ala-Val-Asn-His-Xaa5-Xaa,-Leu-Cys (SEQ ID
NO:33);
Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ser-Val-Asn-His-Xaa5-Xaa,-Leu-Cys (SEQ
IDNO:34);
Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asp-His-Xaa5-Xaa,-Ile-Cys (SEQ
IDNO:35);
Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ser-Gly-Xaa2-Thr-Gln-Xaa, -Xaa5-Cys-Arg-Xaa,-Ser (SEQ ID NO:36);
Xaa5-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ser-Gly-Asn-Asn-Xaa5-Xaa,-Phe-Cys-Arg-Gln (SEQ
ID NO:37);
Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ser-Gly-Asn-Asn-Xaa5-Xaa,-Phe-Cys-Arg-Gln (SEQ
ID NO:38);
Gly-Cys-Cys-Ser-His-Xaa5-Xaa5-Cys-Ala-Met-Asn-Asn-Xaa5-Asp-Xaa4-Cys (SEQ ID
NO:39);
Gly-Cys-Cys-Ser-His-Xaa5-Xaa5-Cys-Phe-Leu-Asn-Asn-Xaa5-Asp-Xaa4-Cys (SEQ ID
NO:40);
Gly-Cys-Cys-Ser-Asn-Xaa5-Xaa5-Cys-Ile-Ala-Xaa2-Asn-Xaa5-His-Met-Cys-Gly (SEQ
ID
NO:41);
Gly-Cys-Cys-Ser-Asn-Xaa5-Ala-Cys-Ala-Gly-Asn-Asn-Xaa5-His-Val-Cys-Arg-Gln (SEQ
ID NO:43);
Gly-Cys-Cys-Ser-Arg-Xaa5-Ala-Cys-Ile-Ala-Asn-Asn-Xaa5-Asp-Leu-Cys (SEQ
IDNO:44);
Gly-Cys-Cys-Ser-Asn-Xaa5-Val-Cys-His-Val-Xaa,-His-Xaa5-Xaa,-Leu-Cys-Arg-Arg-Arg-Arg (SEQ ID NO:45);
Gly-Gly-Cys-Cys-Ser-Phe-Xaa5-Ala-Cys-Arg-Xaa2-Xaa5-Arg-Xaa5-Xaa,-Met-Cys-Gly(SEQ
ID NO:46);
Xaa5-Xaa,-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Asn-Ser-Ser-His-Xaa5-Xaa, -Leu-Cys-Gly(SEQ
ID NO:47);
Xaa5-Gln-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Asn-V al-Gly-His-Xaa5-Xaa, -Leu-Cys-Gly(SEQ
ID NO:48);
Xaa6-Val-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Asn-Val-Gly-His-Xaa5-Xaa,-Ile-Cys-Gly (SEQ
ID NO:49);
Gly-Cys-Cys-Ser-Arg-Xaa5-Xaa5-Cys-Ile-Ala-Asn-Asn-Xaa5-Asp-Leu-Cys (SEQ ID
NO:50);

Xaa5-Gln-Cys-Cys-Ser-His-Leu-Ala-Cys-Asn-Val-Asp-His-XaaS-Xaa,-Ile-Cys-Arg (SEQ
ID NO:51);
Gly-Cys-Cys-Ser-Xaa4-Phe-Asp-Cys-Arg-Met-Met-Phe-XaaS-Xaa,-Met-Cys-Gly-Xaa3-Arg (SEQ ID NO:52);
Gly-Gly-Cys-Cys-Ser-Phe-Ala-Ala-Cys-Arg-Xaa2-Xaa4-Arg-XaaS-Xaa,-Met-Cys-Gly(SEQ
ID NO:53);
Gly-Gly-Cys-Cys-Phe-His-XaaS-Val-Cys-Xaa4-Ile-Asn-Leu-Leu-Xaa, -Met-Cys-Arg-Gln-Arg (SEQ ID NO:54);
Ser-Ala-Thr-Cys-Cys-Asn-Xaa4-XaaS-XaaS-Cys-Xaa4-Xaa, -Thr-Xaa4-XaaS-Xaa, -Ser-Cys-Leu (SEQ ID NO:55);
Ala-Cys-Cys-Ala-Xaa4-Xaa5 Xaa5-Cys-Phe-Xaa,-Ala-Xaa4-XaaS-Xaa,-Arg-Cys-Leu (SEQ
ID NO: 56);
Asn-Ala-Xaa, -Cys-Cys-Xaa4-Xaa4-Xaa5-Xaa5-Cys-Xaa4-Xaa, -Al a-Xaa4-Xaa5-Xaa, -Ile-Cys-Leu (SEQ ID NO:57);
Xaa,-Cys-Cys-Thr-Asn-Xaa5-Val-Cys-His-Ala-Xaa,-His-Gln-Xaa,-Leu-Cys-Ala-Arg-Arg-Arg (SEQ ID NO:170);
Gly-Cys-Cys-Ser-Asn-Xaa5-Val-Cys-His-Leu-Xaa,-His-Ser-Asn-Leu-Cys (SEQ ID
NO: 171);
Xaa,-Cys-Cys-Thr-Asn-Xaa5-Val-Cys-His-Val-Xaa,-His-Gln-Xaa, -Leu-Cys-Ala-Arg-Arg-Arg (SEQ ID NO:172);
Xaa6-Xaal-Cys-Cys-Ser-Xaa4-Xaa5-Ala-Cys-Asn-Leu-Asp-His-Xaa5-Xaa,-Leu-Cys (SEQ
ID NO:173);
Xaa5-Xaa, -Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Asn-Ser-Thr-His-Xaa5-Xaa,-Leu-Cys-Gly(SEQ
ID NO:174);
Leu-Asn-Cys-Cys-Met-Ile-Xaa5-Xaa5-Cys-Xaa3-Xaa,-Xaa,-Xaa4-Gly-Asp-Arg-Cys-Ser-Xaa,-Val-Arg (SEQ ID NO:175);
Ala-Phe-Gly-Cys-Cys-Asp-Leu-Ile-Xaa5-Cys-Leu-Xaa, -Arg-Xaa4-Gly-Asn-Arg-Cys-Asn-Xaa,-Val-His (SEQ ID NO:176);
Leu-Gly-Cys-Cys-Asn-V al-Thr-Xaa5-Cys-Xaa3-Xaa, -Xaa2-Xaa4-Gly-Asp-Xaa2-Cys-Asn-Xaa,-Val-Arg (SEQ ID NO:177);
Asp-Xaa,-Cys-Cys-Ser-Asn-Xaa5-Ala-Cys-Arg-V al-Asn-Asn-Xaa5-His-V al-Cys-Arg-Arg-Arg (SEQ ID NO:178);

Leu-Asn-Cys-Cys-S er-I le-Xaa5-Gly-Cys-Xaa3-Asn-Xaa, -Xaa4-Xaa2-Asp-Arg-Cys-Ser-Xaa2-Val-Arg (SEQ ID NO:179);
Gly-Gly-Cys-Cys-Ser-His-Xaa5-Val-Cys-Xaa4-Phe-Asn-Asn-Xaa5-Gln-Met-Cys-Arg (SEQ
ID NO:180);
Gly-Gly-Cys-Cys-Ser-His-Xaa5-Val-Cys-Asn-Leu-Asn-Asn-Xaa5-Gln-Met-Cys-Arg (SEQ
ID NO:181);
Gly-Cys-Cys-Ser-His-Xaa5-Xaa5-Cys-Xaa4-Ala-Asn-Asn-Gln-Ala-Xaa4-Cys-Asn (SEQ
ID
NO:182);
Gly-Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ser-Val-Thr-His-Xaa5-Xaa,-Leu-Cys (SEQ ID
NO:183);
Gly-Gly-Cys-Cys-Ser-Xaa4-Xaa5-Ala-Cys-Ser-Val-Xaa,-His-Gln-Asp-Leu-Cys-Asp (SEQ
ID NO:184);
V al-Ser-Cys-Cys-V al-V al-Arg-Xaa5-Cys-Xaa3-I le-Arg-Xaa4-Gln-Xaa, -Xaa, -Cys-Leu-Xaa, -Ala-Asp-Xaa5-Arg-Thr-Leu (SEQ ID NO: 185);
Xaa6-Asn-Cys-Cys-Ser-Ile-Xaa5-Gly-Cys-Xaa3-Xaa,-Xaa,-Xaa4-Gly-Asp-Xaa2-Cys-Ser-Xaa,-Val-Arg (SEQ ID NO:186);
G1y-Cys-Cys-Ser-Asn-Xaa5-Val-Cys-His-Leu-Xaa,-His-Xaa5-Asn-Ala-Cys (SEQ ID
NO:187);
Gly-Cys-Cys-Ser-Asn-Xaa5-Ile-Cys-Xaa4-Phe-Asn-Asn-Xaa5-Arg-Ile-Cys-Arg (SEQ ID
NO:188);
Xaa,-Cys-Cys-Ser-Gln-Xaa5-Xaa5-Cys-Arg-Xaa3-Xaa2-His-Xaa5-Xaa,-Leu-Cys-Ser (SEQ
ID NO:189);
Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ala-Gly-Asn-Asn-Gln-His-Ile-Cys (SEQ ID NO:
190);
Gly-Cys-Cys-Ala-Val-Xaa5-Ser-Cys-Arg-Leu-Arg-Asn-Xaa5-Asp-Leu-Cys-Gly-Gly (SEQ
ID NO:191);
G1y-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asn-Asn-Xaa5-His-Ile-Cys(SEQIDNO:192);
Thr-Xaa5-Xaa,-Xaa,-Cys-Cys-Xaa5-Asn-Xaa5-Xaa5-Cys-Phe-Ala-Thr-Asn-Ser-Asp-Ile-Cys-Gly (SEQ ID NO:193);
Asp-Ala-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Ser-Gly-Xaa2-His-Gln-Asp-Leu-Cys (SEQ ID
NO:194);
Xaa,-Asp-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Ser-Val-Gly-His-Gln-Asp-Leu-Cys (SEQ ID
NO:195);

Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ala-Gly-Ser-Asn-Ala-His-Ile-Cys (SEQ ID
NO:196);
Xaa,-Asp-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Ser-Val-Gly-His-Gln-Asp-Met-Cys (SEQ ID
NO:197);
Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ala-Gly-Asn-Asn-Xaa5-His-Ile-Cys (SEQ
IDNO:198);
5 Gly-Cys-Cys-Gly-Asn-Xaa5-Ser-Cys-Ser-Ile-His-Ile-Xaa5-Xaa4-Val-Cys-Asn (SEQ
ID
NO:199);
Thr-Asp-Ser-Xaa,-Xaa,-Cys-Cys-Leu-Asp-Ser-Arg-Cys-Ala-Gly-Gln-His-Gln-Asp-Leu-Cys-Gly (SEQ ID NO:200);
Gly-Cys-Cys-Ser-Asn-Xaa5-Xaa5-Cys-Xaa4-Ala-Asn-Asn-Gln-Ala-Xaa4-Cys-Asn (SEQ
ID
10 NO:201);
Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ser-V al-Asn-Asn-Xaa5-Asp-Ile-Cys (SEQ ID
NO:202);
Gly-Xaa,-Cys-Cys-Ile-Asn-Asp-Ala-Cys-Arg-Ser-Xaa,-His-Xaa5-Gln-Xaa4-Cys-Ser (SEQ
ID NO:203);
Gly-Cys-Cys-Xaa4-Asn-Ile-Ala-Cys-Arg-Ile-Asn-Asn-Xaa5-Arg-Xaa4-Cys-Arg (SEQ ID

15 NO:204);
Gly-Cys-Cys-Ser-His-Xaa5-Val-Cys-Arg-Phe-Asn-Xaa4-Xaa5-Xaa2-Xaa4-Cys-Gly (SEQ
ID
NO:205);
Asp-Xaa,-Cys-Cys-Ala-Ser-Xaa5-Xaa5-Cys-Arg-Leu-Asn-Asn-Xaa5-Xaa4-Val-Cys-His (SEQ ID NO:206);
Gly-Cys-Cys-Ser-Asn-Xaa5-Val-Cys-Xaa3-Gln-Asn-Asn-Ala-Xaa,-Xaa4-Cys-Arg-Xaa,-Ser (SEQ ID NO:207);
Gly-Cys-Cys-Ser-His-Xaa5-Xaa5-Cys-Ala-Gln-Asn-Asn-Gln-Asp-Xaa4-Cys (SEQ ID
NO:208);
Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ser-Gly-Asn-Asn-Arg-Xaa, -Xaa4-Cys-Arg-Xaa,-Ser (SEQ ID NO:209);
Asp-Xaa5-Cys-Cys-Ser-Xaa4-Xaa5-Asp-Cys-Gly-Ala-Asn-His-Xaa5-Xaa,-Ile-Cys-Gly (SEQ
ID NO:210);
Xaa,-Cys-Cys-Ser-Gln-Xaa5-Xaa5-Cys-Arg-Xaa3-Xaa,-His-Xaa5-Xaa,-Leu-Cys-Ser (SEQ
ID NO:211);
Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Ala-Gly-Asn-Asn-Xaa5-His-Ile-Cys (SEQ
IDNO:212);
Gly-Cys-Cys-Ser-Asp-Xaa5-Ser-Cys-Asn-Val-Asn-Asn-Xaa5-Asp-Xaa4-Cys (SEQ ID
NO:213);

Xaa,-Xaa,-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Ser-Val-Gly-His-Gln-Asp-Met-Cys-Arg (SEQ
ID NO:214);
Gly-Gly-Cys-Cys-Ser-Asn-Xaa5-Ala-Cys-Leu-Val-Asn-His-Leu-Xaa,-Met-Cys (SEQ ID
NO:215);
Arg-Asp-Xaa5-Cys-Cys-Phe-Asn-Xaa5-Ala-Cys-Asn-Val-Asn-Asn-Xaa5-Gln-Ile-Cys (SEQ
ID NO:216);
Cys-Cys-Ser-Asp-Xaa5-Ser-Cys-Xaa3-Arg-Leu-His-Ser-Leu-Ala-Cys-Thr-Gly-Ile-Val-Asn-Arg (SEQ ID NO:217);
Cys-Cys-Thr-Asn-Xaa5-Ala-Cys-Leu-Val-Asn-Asn-Ile-Arg-Phe-Cys-Gly(SEQIDNO:218);
Asp-Xaa,-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-His-Gly-Asn-Asn-Arg-Asp-His-Cys-Ala (SEQ
ID NO:219);
Asp-Cys-Cys-Ser-His-Xaa5-Leu-Cys-Arg-Leu-Phe-Val-Xaa5-Gly-Leu-Cys-Ile (SEQ ID
NO:220);
Gly-Cys-Cys-Ser-His-Xaa5-Val-Cys-Xaa2-Val-Arg-Xaa4-Xaa5-Asp-Leu-Cys-Arg (SEQ
ID
NO:221);
Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asn-Asn-Xaa5-His-Ile-Cys (SEQIDNO:222);
Gly-Cys-Cys-Ser-His-Xaa5-Val-Cys-Xaa2-Val-Arg-Xaa4-Ser-Asp-Met-Cys (SEQ ID
NO:223);
Gly-Gly-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Xaa2-Val-His-Phe-Xaa5-His-Ser-Cys (SEQ ID
NO:224);
V al-Cys-Cys-Ser-Asn-Xaa5-Val-Cys-His-V al-Asp-His-Xaa5-Xaa, -Leu-Cys-Arg-Arg-Arg-Arg (SEQ ID NO:225);
Gly-Cys-Cys-Ser-His-Xaa5-Val-Cys-Asn-Leu-Ser-Asn-Xaa5-Gln-Ile-Cys-Arg (SEQ ID
NO:226);
Xaa6-Xaa,-Cys-Cys-Ser-His-Xaa5-Ala-Cys-Asn-Val-Asp-His-Xaa5-Xaa,-Ile-Cys-Arg (SEQ
ID NO:227);
Gly-Cys-Cys-Ser-Asn-Xaa5-Ala-Cys-Leu-Val-Asn-His-Ile-Arg-Phe-Cys-Gly (SEQ ID
NO:228);
Asp-Cys-Cys-Asp-Asp-Xaa5-Ala-Cys-Thr-Val-Asn-Asn-Xaa5-Gly-Leu-Cys-Thr (SEQ ID
NO:229); and Gly-Cys-Cys-Ser-Asn-Xaa5-Xaa5-Cys-Ile-Ala-Xaa2-Asn-Xaa5-His-Met-Cys-Gly-Gly-Arg-Arg (SEQ ID NO:230), wherein Xaa, is Glu or y-carboxy-Glu (Gla); Xaa2 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys; Xaa3 is Trp (D or L), halo-Trp or neo-Trp; Xaa4 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr; and Xaa5 is Pro or hydroxy-Pro; Xaa6 is Gln or pyro-Glu; and the C-terminus contains a carboxyl or amide group. The halo is preferably bromine, chlorine or iodine, more preferably iodine for Tyr and bromine for Trp. In addition, the His residues may be substituted with halo-His; the Arg residues may be substituted by Lys, ornithine, homoargine, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; the Lys residues may be substituted by Arg, ornithine, homoargine, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; the Tyr residues may be substituted with any unnatural hydroxy containing amino acid; the Ser residues may be substituted with Thr; the Thr residues may be substituted with Ser; and the Phe and Trp residues may be substituted with any unnatural aromatic amino acid. The Cys residues may be in D or L
configuration and may optionally be substituted with homocysteine (D or L).
The Tyr residues may be substituted with the 3-hydroxyl or 2-hydroxyl isomers and corresponding O-sulpho- and 0-phospho-derivatives. The acidic amino acid residues may be substituted with any synthetic acidic bioisoteric amino acid surrogate, e.g., tetrazolyl derivatives of Gly and Ala.
More specifically, the present invention is directed to the following a-conotoxin peptides of general formula III:
SmI: SEQ ID NO:22, wherein Xaa, is Glu and Xaa5 is Pro;
OB-29: SEQ ID NO:23, wherein Xaa, is Glu, Xaa3 is Tyr and Xaa5 is Pro;
Txl.1: SEQ ID NO:24, wherein Xaa, is Glu and Xaa5 is Pro;

R1.IA: SEQ ID NO:25, wherein Xaa, is Glu and Xaa5 is Pro;
R1.1B: SEQ ID NO:26, wherein Xaa, is Glu and Xaa5 is Pro;
Om-9: SEQ ID NO:27, wherein Xaa, is Glu and Xaa5 is Pro;
Om-10: SEQ ID NO:28, wherein Xaa5 is Pro;
Om-21: SEQ ID NO:29, wherein Xaa, is Glu and Xaa5 is Pro;
Om-25: SEQ ID NO:30, wherein Xaa, is Glu and Xaa5 is Pro;
Om-27: SEQ ID NO:31, wherein Xaa, is Glu and Xaa5 is Pro;
Om-28: SEQ ID NO:32, wherein Xaa, is Glu and Xaa5 is Pro;

Btl.2: SEQ ID NO:33, wherein Xaa, is Glu and Xaa5 is Pro;
Btl.4: SEQ ID NO:34, wherein Xaa, is Glu and Xaa5 is Pro;
Dal.1: SEQ ID NO:35, wherein Xaa, is Glu and Xaa5 is Pro;

OB-20: SEQ ID NO:36, wherein Xaa, is Glu, Xaa2 is Lys and Xaa5 is Pro;
TI: SEQ ID NO:37, wherein Xaa, is Glu and Xaa5 is Pro;

TIB: SEQ ID NO:38, wherein Xaa, is Glu and Xaa5 is Pro;
Pnl.l : SEQ ID NO:39, wherein XaaS is Pro;

Pnl.2: SEQ ID NO:40, wherein Xaa, is Glu and Xaa5 is Pro;
TI: SEQ ID NO:41, wherein Xaa2 is Lys and XaaS is Pro;
TIA: SEQ ID NO:43, wherein Xaa5 is Pro;

Dal.2: SEQ ID NO:44, wherein Xaa5 is Pro;

Cr1.2: SEQ ID NO:45, wherein Xaa, is Glu and Xaa5 is Pro;

S11.2: SEQ ID NO:46, wherein Xaa, is Glu, Xaa2 is Lys and XaaS is Pro;
Txl.3: SEQ ID NO:47, wherein Xaa, is Glu and Xaa5 is Pro;

Dal.3: SEQ ID NO:48, wherein Xaa, is Glu and Xaa5 is Pro;

Dal.4: SEQ ID NO:49, wherein Xaa, is Glu, Xaa5 is Pro and Xaa6 is Gln;
Txl.2: SEQ ID NO:50, wherein Xaa5 is Pro;

Om-35: SEQ ID NO:51, wherein Xaa, is Glu and XaaS is Pro;
S1l.1: SEQ ID NO:52, wherein Xaa, is Glu, Xaa3 is Trp, Xaa4 is Tyr and Xaa5 is Pro;
S11.6: SEQ ID NO:53, wherein Xaa, is Glu, Xaa, is Lys, Xaa4 is Tyr and Xaa5 is Pro;
S11.7: SEQ ID NO:54, wherein Xaa, is Glu Xaa4 is Tyr and XaaS is Pro;
Bt1.1: SEQ ID NO:55, wherein Xaa, is Glu Xaa4 is Tyr and Xaa5 is Pro;
Bt:1.3: SEQ ID NO:56, wherein Xaa, is Glu Xaa4 is Tyr and XaaS is Pro;
Btl.5: SEQ ID NO:57, wherein Xaa, is Glu Xaa4 is Tyr and Xaa5 is Pro;
A1.4: SEQ ID NO:170, wherein Xaa, is Glu and Xaa5 is Pro;

A1.5: SEQ ID NO:171, wherein Xaa, is Glu and Xaa5 is Pro;
A1.6: SEQ ID NO:172, wherein Xaa, is Glu and Xaa5 is Pro;

Afl.1: SEQ ID NO:173, wherein Xaa, is Glu Xaa4 is Tyr, Xaa5 is Pro and Xaa6 is Gln;
Afl.2: SEQ ID NO: 174, wherein Xaa, is Glu and Xaa5 is Pro;

Arl.2: SEQ ID NO: 175, wherein Xaa, is Glu, Xaa2 is Lys, Xaa3 is Trp, Xaa4 is Try and Xaa5 is Pro;
Arl.3: SEQ ID NO: 176, wherein Xaa, is Glu, Xaa4 is Tyr and Xaa5 is Pro;

Arl.4: SEQ ID NO:177, wherein Xaa, is Glu, Xaaz is Lys, Xaa3 is Tip, Xaa4is Try and Xaa5 is Pro;
Arl.5: SEQ ID NO:178, wherein Xaa3 is Glu and Xaa5 is Pro;

Arl.6: SEQ ID NO:179, wherein Xaa, is Glu, Xaaz is Lys, Xaa3 is Trp, Xaa4 is Try and Xaa5 is Pro;
Ayl.2: SEQ ID NO:180, wherein Xaa4 is Tyr and Xaa5 is Pro;
Ayl.3: SEQ ID NO:181, wherein Xaa5 is Pro;

Bnl.4: SEQ ID NO:182, wherein Xaa4 is Tyr and Xaa5 is Pro;
Btl.8: SEQ ID NO:183, wherein Xaa, is Glu and Xaa5 is Pro;

Btl.9: SEQ ID NO: 184, wherein Xaa1 is Glu, Xaa4 is Tyr and Xaa5 is Pro;
Cal.3: SEQ ID NO:185, wherein Xaa1 is Glu, Xaa3 is Trp, Xaa4 is Try and Xaa5 is Pro;
Cal.4: SEQ ID NO:186, wherein Xaa1 is Glu, Xaaz is Lys, Xaa3 is Trp, Xaa4 is Try, Xaa5 is Pro and Xaa6 is Gln;
C1.2: SEQ ID NO:187, wherein Xaa1 is Glu and Xaa5 is Pro;
C1.3: SEQ ID NO:188, wherein Xaa4 is Tyr and Xaa5 is Pro;
Epl.2: SEQ ID NO:189, wherein Xaa, is Glu, Xaa2 is Lys, Xaa3 is Trp and Xaa5 is Pro;
G1.1: SEQ ID NO:190, wherein Xaa5 is Pro;
G1.3: SEQ ID NO:191, wherein Xaa5 is Pro;
Iml.3: SEQ ID NO:192, wherein Xaa5 is Pro;

Lvl.2: SEQ ID NO:193, wherein Xaa1 is Glu and Xaa5 is Pro;
Lvl.3: SEQ ID NO:194, wherein Xaa2 is Lys and Xaa5 is Pro;
Lvl.4: SEQ ID NO:195, wherein Xaa, is Glu and Xaa5 is Pro;
Lvl.6: SEQ ID NO:196, wherein Xaa5 is Pro;
Lvl.7: SEQ ID NO:197, wherein Xaa1 is Glu and Xaa5 is Pro;
Lvl.8: SEQ ID NO:198, wherein Xaa5 is Pro;
Lvl.9: SEQ ID NO:199, wherein Xaa4 is Tyr and Xaa5 is Pro;
Lvl.10: SEQ ID NO:200, wherein Xaa1 is Glu;

Mrl.3: SEQ ID NO:201, wherein Xaa4 is Tyr and Xaa5 is Pro;
Mrl.4: SEQ ID NO:202, wherein Xaa5 is Pro;
Msl.1: SEQ ID NO:203, wherein Xaa2 is Lys, Xaa4 is Tyr and Xaa5 is Pro;

Msl.6: SEQ ID NO:204, wherein Xaa4 is Tyr and Xaa5 is Pro;

01.1: SEQ ID NO:205, wherein Xaa2 is Lys, Xaa4 is Tyr and Xaa5 is Pro;
01.2: SEQ ID NO:206, wherein Xaa, is Glu, Xaa4 is Tyr and Xaa5 is Pro;

01.4: SEQ ID NO:207, wherein Xaa, is Glu, Xaa3 is Trp, Xaa4 is Tyr and Xaa5 is 5 Pro;
01.7: SEQ ID NO:208, wherein Xaa4 is Tyr and Xaa5 is Pro;

01.8: SEQ ID NO:209, wherein Xaa, is Glu, Xaa4 is Tyr and Xaa5 is Pro;
Oml.2: SEQ ID NO:210, wherein Xaa, is Glu, Xaa4 is Tyr and Xaa5 is Pro;
Oml.3: SEQ ID NO:211, wherein Xaa, is Glu, Xaa2 is Lys, Xaa3 is Trp and Xaa5 is 10 Pro;
Om1.4: SEQ ID NO:212, wherein Xaa5 is Pro;

Oml.5: SEQ ID NO:213, wherein Xaa4 is Tyr and Xaa5 is Pro;
Oml.6: SEQ ID NO:214, wherein Xaa, is Glu and Xaa5 is Pro;
P1.4: SEQ ID NO:215, wherein Xaa, is Glu and Xaa5 is Pro;
15 P1.5: SEQ ID NO:216, wherein Xaa5 is Pro;
P1.6: SEQ ID NO:217, wherein Xaa3 is Trp and Xaa5 is Pro;
P1.8: SEQ ID NO:218, wherein Xaa5 is Pro;
Rg 1.1: SEQ ID NO:219, wherein Xaa, is Glu and Xaa5 is Pro;
Rgl.3: SEQ ID NO:220, wherein Xaa5 is Pro;

20 Rgl.4: SEQ ID NO:221, wherein Xaa2 is Lys, Xaa4 is Tyr and Xaa5 is Pro;
Rgl.5: SEQ ID NO:222, wherein Xaa5 is Pro;

Rgl.8: SEQ ID NO:223, wherein Xaa2 is Lys, Xaa4 is Tyr and Xaa5 is Pro;
Sm1.4: SEQ ID NO:224, wherein Xaa2 is Lys and Xaa5 is Pro;

Sml.5: SEQ ID NO:225, wherein Xaa, is Glu and Xaa5 is Pro;
S I.5: SEQ ID NO:226, wherein Xaa5 is Pro;
Txl.5: SEQ ID NO:227, wherein Xaa, is Glu, Xaa5 is Pro and Xaab is Gln;
T1.1: SEQ ID NO:228, wherein Xaa5 is Pro;

Vrl.3: SEQ ID NO:229, wherein Xaa5 is Pro; and Tb: SEQ ID NO:230, wherein Xaa2 is Lys and Xaa5 is Pro.

The C-terminus preferably contains a carboxyl group for the peptides OB-29, Txl.l, RI.1A, R1.1B, Om-9, Om-10, Om-21, Om-25, Om-27, Om-28, Cr1.2, Om-35, Btl.l, Btl.3, Btl.5, A1.4, A1.6, Arl.2, Arl.3, Arl.4, Arl.5, Arl.6, Cal.3, Cal.4, Epl.2, Lvl.9, 01.2, Oml.3, Oml.6, P1.6, Rgl.l, Rg1.3, Rgl.4, Sm1.5, Tx1.5 and Vrl.3. The C-terminus of the other peptides preferably contains an amide group.

The present invention is also directed to the novel specific a-contoxin peptides having the formulas:

Cys-Cys-Thr-Ile-Xaa5-Ser-Cys-Xaa4-Xaa,-Xaa2-Xaa,-Xaa2-Ile-Xaa2-Ala-Cys-Val-Phe (SEQ
ID NO:231) and Gly-Cys-Cys-Gly-Asn-Xaa5-Ala-Cys-Ser-Gly-Ser-Ser-Xaa2-Asp-Ala-Xaa5-Ser-Cys (SEQ
ID NO:232), wherein Xaa, is Glu or y-carboxy-Glu (Gla); Xaa2 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys; Xaa4 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr; and Xaa5 is Pro or hydroxy-Pro; and the C-terminus contains a carboxyl or amide group. The halo is preferably bromine, chlorine or iodine, more preferably iodine for Tyr. In addition, the His residues may be substituted with halo-His; the Arg residues may be substituted by Lys, ornithine, homoargine, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; the Lys residues may be substituted by Arg, ornithine, homoargine, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; the Tyr residues may be substituted with any unnatural hydroxy containing amino acid;
the Ser residues may be substituted with Thr; the Thr residues may be substituted with Ser; and the Phe residues may be substituted with any unnatural aromatic amino acid. The Cys residues may be in D or L

configuration and may optionally be substituted with homocysteine (D or L).
The Tyr residues may be substituted with the 3-hydroxyl or 2-hydroxyl isomers and corresponding O-sulpho- and 0-phospho-derivatives. The acidic amino acid residues may be substituted with any synthetic acidic bioisoteric amino acid surrogate, e.g., tetrazolyl derivatives of Gly and Ala.

More specifically, the present invention is directed to the following a-conotoxin peptides:
G1.2: SEQ ID NO:231, wherein Xaa, is Glu, Xaa2 is Lys, Xaa4 is Tyr and Xaa5 is Pro; and Rg1.12: SEQ ID NO:232, wherein Xaa2 is Lys and Xaa5 is Pro.

The C-terminus of G1.2 preferably contains a carboxyl group, and the C-terminus of Rgl.12 preferably contains an amide group.

Examples of unnatural aromatic amino acid include, but are not limited to, such as nitro-Phe, 4-substituted-Phe wherein the substituent is C1-C3 alkyl, carboxyl, hyrdroxymethyl, sulphomethyl, halo, phenyl, -CHO, -CN, -SO3H and -NHAc. Examples of unnatural hydroxy containing amino acid, include, but are not limited to, such as 4-hydroxymethyl-Phe, 4-hydroxyphenyl-Gly, 2,6- dimethyl-Tyr and 5-amino-Tyr. Examples of unnatural basic amino acids include, but are not limited to, N-1-(2-pyrazolinyl)-Arg, 2-(4-piperinyl)-Gly, 2-(4-piperinyl)-Ala, 2-[3-(2S)pyrrolininyl)- Gly and 2-[3-(2S) pyrrolininyl)-Ala. These and other unnatural basic amino acids, unnatural hydroxy containing amino acids or unnatural aromatic amino acids are described in Building Block Index, Version 3.0 (1999 Catalog, pages 4-47 for hydroxy containing amino acids and aromatic amino acids and pages 66-87 for basic amino acids by and available from RSP Amino Acid Analogues, Inc., Worcester, MA.

Optionally, in the peptides of general formulas I, II and III and the specific peptides described above, the Asn residues may be modified to contain an N-glycan and the Ser and Thr residues may be modified to contain an 0-glycan. In accordance with the present invention, a glycan shall mean any N-, S- or O-linked mono-, di-, tri-, poly- or oligosaccharide that can be attached to any hydroxy, amino or thiol group of natural or modified amino acids by synthetic or enzymatic methodologies known in the art.
The monosaccharides making up the glycan can include D-allose, D-altrose, D-glucose, D-mannose, D-gulose, D-idose, D-galactose, D-talose, D- galactosamine, D-glucosamine, D-N-acetyl-glucosamine (G1cNAc), D-N-acetyl-galactosamine (Ga1NAc), D-fucose or D-arabinose. These saccharides may be structurally modified, e. g., with one or more O-sulfate, 0-phosphate, O-acetyl or acidic groups, such as sialic acid, including combinations thereof.
The gylcan may also include similar polyhydroxy groups, such as D-penicillamine 2,5 and halogenated derivatives thereof or polypropylene glycol derivatives. The glycosidic linkage is beta and 1-4 or 1-3, preferably 1-3. The linkage between the glycan and the amino acid may be alpha or beta, preferably alpha and is 1-.

Core 0-glycans have been described by Van de Steen et al. (1998). Mucin type O-linked oligosaccharides are attached to Ser or Thr (or other hydroxylated residues of the present peptides) by a GaINAc residue. The monosaccharide building blocks and the linkage attached to this first GaINAc residue define the"core glycans, "of which eight have been identified. The type of glycosidic linkage (orientation and connectivities) are defined for each core glycan. Suitable glycans and glycan analogs are described further in U.S.
Patent 6,369,193, filed 19 October 1999. A preferred glycan is Gal(0l---3)GalNAc Optionally, in the peptides of general formulas I and II and the specific peptides described above, pairs of Cys residues may be replaced pairwise with Ser/(Glu or Asp) or Lys/(Glu or Asp) combinations. Sequential coupling by known methods (Barnay et al., 2000;
Hruby et al., 1994; Bitan et al., 1997) allows replacement of native Cys bridges with lactam bridges.

The present invention is further directed to propeptides and nucleic acid sequences encoding the propeptides or peptides as described in further detail herein.

DETAILED DESCRIPTION OF THE INVENTION

The invention relates to relatively short peptides (termed a-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

The present invention, in another aspect, relates to a pharmaceutical composition comprising an effective amount of an a -conotoxin peptide. Such a pharmaceutical composition has the capability of acting as antagonists for nicotinic acetylcholine receptors.
In one aspect, the a-conotoxins with specificity for neuromuscular junction nicotinic acetylcholine receptors are used as neuromuscular blocking agents for use in conjunction with surgery, as disclosed in U.S. patent 6,268,473, filed 21 January 2000 (Attorney Docket No. 2314-178.A) and international patent publication no.WO 00/43409, filed 21 January 2000 (Attorney Docket No. 2314-138. PCT). In a second aspect, additional a -conotoxins and uses for them have been described in U. S. Patent Nos. 4,447, 356 (Olivera et al., 1984);
5,432,155; 5,514,774.

In a third aspect additional uses for a-conotoxins are described in U.S.
Patent No. 6,265,541, filed 22 December 1998. In this application, a-conotoxins with specificity for neuronal nicotinic acetylcholine receptors are used for treating disorders regulated at neuronal nicotinic acetylcholine receptors. Such disorders include, but are not limited to, cardiovascular disorders, gastric motility disorders, urinary incontinence, nicotine addiction, mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal 23a effective disorder) and small cell lung carcinoma, as well as the localization of small cell lung carcinoma.

The a-conotoxin peptides described herein are sufficiently small to be chemically synthesized. General chemical syntheses for preparing the foregoing a -conotoxin peptides are described hereinafter. Various ones of the a-conotoxin peptides can also be obtained by isolation and purification from specific Conus species using the technique described in U.S. Patent No.
4,447,356 (Olivera et al., 1984).
Although the a-conotoxin peptides of the present invention can be obtained by purification from cone snails, because the amounts of a-conotoxin peptides obtainable from individual snails are very small, the desired substantially pure a-conotoxin peptides are best practically obtained in commercially valuable amounts by chem cal synthesis using solid-phase strategy. For example, the yield from a single cone snail may be a .out 10 micrograms or less of a-conotoxin peptide. By "substantially pure" is meant that the peptide is present in the substantial absence of other biological molecules of the same type; it is preferably present in an amount of at least about 85% purity and preferably at least about 95% purity. Chemical synthesis of biologically active a-conotoxin peptides depends of course upon correct determination of the amino acid sequence.
The a-conotoxin peptides can also be produced by recombinant DNA techniques well known in the art. Such techniques are described by Sambrook et al. (1989). The peptides produced in this manner are isolated, reduced if necessary, and oxidized to form the correct disulfide bonds.
One method of forming disulfide bonds in the conantokin peptides of the present invention is the air oxidation of the linear peptides for prolonged periods under cold room temperatures or at room temperature. This procedure results in the creation of a substantial amount of the bioactive, disulfide-linked peptides. The oxidized peptides are fractionated using reverse-phase high performance liquid chromatography (HPLC) or the like, to separate peptides having different linked configurations. Thereafter, either by comparing these fractions with the elution of the native material or by using a simple assay, the particular fraction having the correct linkage for maximum biological potency is easily determined. However, because of the dilution resulting from the presence of other fractions of less biopotency, a somewhat higher dosage may be required.
The peptides are synthesized by a suitable method, such as by exclusively solid-phase techniques, by partial solid-phase techniques, by fragment condensation or by classical solution couplings.

In conventional solution phase peptide synthesis, the peptide chain can be prepared by a series of coupling reactions in which constituent amino acids are added to the growing peptide chain in the desired sequence. Use of various coupling reagents, e.g., dicyclohexylcarbodiimide or diisopropylcarbonyldimidazole, various active esters, e.g., esters of N-hydroxyphthalimide or N-hydroxy-succinimide, and the various cleavage reagents, to carry out reaction in solution, with subsequent isolation and purification of intermediates, is well known classical peptide methodology.

Classical solution synthesis is described in detail in the treatise, "Methoden der Organischen Chemie (Houben-Weyl): Synthese von Peptiden," (1974). Techniques of exclusively solid-phase synthesis are set forth in the textbook, "Solid-Phase Peptide Synthesis," (Stewart and Young, 1969), and are exemplified by the disclosure of U.S. Patent 4,105,603 (Vale et al., 1978).
The fragment 5 condensation method of synthesis is exemplified in U.S. Patent 3,972,859 (1976). Other available syntheses are exemplified by U.S. Patents No. 3,842,067 (1974) and 3,862,925 (1975). The synthesis of peptides containing y-carboxyglutamic acid residues is exemplified by Rivier et al.
(1987), Nishiuchi et al. (1993) and Zhou et al. (1996).
Common to such chemical syntheses is the protection of the labile side chain groups of the 10 various amino acid moieties with suitable protecting groups which will prevent a chemical reaction from occurring at that site until the group is ultimately removed. Usually also common is the protection of an a-amino group on an amino acid or a fragment while that entity reacts at the carboxyl group, followed by the selective removal of the a-amino protecting group to allow subsequent reaction to take place at that location. Accordingly, it is common that, as a step in such 15 a synthesis, an intermediate compound is produced which includes each of the amino acid residues located in its desired sequence in the peptide chain with appropriate side-chain protecting groups linked to various ones of the residues having labile side chains.
As far as the selection of a side chain amino protecting group is concerned, generally one is chosen which is not removed during deprotection of the a-amino groups during the synthesis.
20 However, for some amino acids, e.g., His, protection is not generally necessary. In selecting a particular side chain protecting group to be used in the synthesis of the peptides, the following general rules are followed: (a) the protecting group preferably retains its protecting properties and is not split off under coupling conditions, (b) the protecting group should be stable under the reaction conditions selected for removing the a-amino protecting group at each step of the synthesis, 25 and (c) the side chain protecting group must be removable, upon the completion of the synthesis containing the desired amino acid sequence, under reaction conditions that will not undesirably alter the peptide chain.
It should be possible to prepare many, or even all, of these peptides using recombinant DNA
technology. However, when peptides are not so prepared, they are preferably prepared using the Merrifield solid-phase synthesis, although other equivalent chemical syntheses known in the art can also be used as previously mentioned. Solid-phase synthesis is commenced from the C-terminus of the peptide by coupling a protected a-amino acid to a suitable resin. Such a starting material can be prepared by attaching an a-amino-protected amino acid by an ester linkage to a chloromethylated resin or a hydroxymethyl resin, or by an amide bond to a benzhydrylamine (BHA) resin or para-methylbenzhydrylamine (MBHA) resin. Preparation of the hydroxymethyl resin is described by Bodansky et al. (1966). Chloromethylated resins are commercially available from Bio Rad Laboratories (Richmond, CA) and from Lab. Systems, Inc. The preparation of such a resin is described by Stewart and Young (1969). BHA and MBHA resin supports are commercially available, and are generally used when the desired polypeptide being synthesized has an unsubstituted amide at the C-terminus. Thus, solid resin supports may be any of those known in the art, such as one having the formulae -O-CH2-resin support, -NH BHA resin support, or -NH-MBHA
resin support. When the unsubstituted amide is desired, use of a BHA or MBHA
resin is preferred, because cleavage directly gives the amide. In case the N-methyl amide is desired, it can be generated from an N-methyl BHA resin. Should other substituted amides be desired, the teaching of U.S. Patent No. 4,569,967 (Kornreich et al., 1986) can be used, or should still other groups than the free acid be desired at the C-terminus, it may be preferable to synthesize the peptide using classical methods as set forth in the Houben-Weyl text (1974).
The C-terminal amino acid, protected by Boc or Fmoc and by a side-chain protecting group, if appropriate, can be first coupled to a chloromethylated resin according to the procedure set forth in K. Horiki et al. (1978), using KF in DMF at about 60 C for 24 hours with stirring, when a peptide having free acid at the C-terminus is to be synthesized. Following the coupling of the BOC-protected amino acid to the resin support, the a-amino protecting group is removed, as by using trifluoroacetic acid (TFA) in methylene chloride or TFA alone. The deprotection is carried out at a temperature between about 0 C and room temperature. Other standard cleaving reagents, such as HCl in dioxane, and conditions for removal of specific a-amino protecting groups may be used as described in Schroder & Lubke (1965).
After removal of the a-amino-protecting group, the remaining a-amino- and side chain-protected amino acids are coupled step-wise in the desired order to obtain the intermediate compound defined hereinbefore, or as an alternative to adding each amino acid separately in the synthesis, some of them may be coupled to one another prior to addition to the solid phase reactor.
Selection of an appropriate coupling reagent is within the skill of the art.
Particularly suitable as a coupling reagent is N,N'-dicyclohexylcarbodiimide (DCC, DIC, HBTU, HATU, TBTU in the presence of HoBt or HoAt).

The activating reagents used in the solid phase synthesis of the peptides are well known in the peptide art. Examples of suitable activating reagents are carbodiimides, such as N,N'-diisopropylcarbodiimide and N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide.
Other activating reagents and their use in peptide coupling are described by Schroder & Lubke (1965) and Kapoor (1970).
Each protected amino acid or amino acid sequence is introduced into the solid-phase reactor in about a twofold or more excess, and the coupling may be carried out in a medium of dimethylformamide (DMF):CH2C12 (1:1) or in DMF or CH2Cl2 alone. In cases where intermediate coupling occurs, the coupling procedure is repeated before removal of the a-amino protecting group prior to the coupling of the next amino acid. The success of the coupling reaction at each stage of the synthesis, if performed manually, is preferably monitored by the ninhydrin reaction, as described by Kaiser et al. (1970). Coupling reactions can be performed automatically, as on a Beckman 990 automatic synthesizer, using a program such as that reported in Rivier et al.
(1978).
After the desired amino acid sequence has been completed, the intermediate peptide can be removed from the resin support by treatment with a reagent, such as liquid hydrogen fluoride or TFA (if using Fmoc chemistry), which not only cleaves the peptide from the resin but also cleaves all remaining side chain protecting groups and also the a-amino protecting group at the N-terminus if it was not previously removed to obtain the peptide in the form of the free acid. If Met is present in the sequence, the Boc protecting group is preferably first removed using trifluoroacetic acid (TFA)/ethanedithiol prior to cleaving the peptide from the resin with HF to eliminate potential S-alkylation. When using hydrogen fluoride or TFA for cleaving, one or more scavengers such as anisole, cresol, dimethyl sulfide and methylethyl sulfide are included in the reaction vessel.
Cyclization of the linear peptide is preferably affected, as opposed to cyclizing the peptide while a part of the peptido-resin, to create bonds between Cys residues. To effect such a disulfide cyclizing linkage, fully protected peptide can be cleaved from a hydroxymethylated resin or a chloromethylated resin support by ammonolysis, as is well known in the art, to yield the fully protected amide intermediate, which is thereafter suitably cyclized and deprotected. Alternatively, deprotection, as well as cleavage of the peptide from the above resins or a benzhydrylamine (BHA) resin or a methylbenzhydrylamine (MBHA), can take place at 0 C with hydrofluoric acid (HF) or TFA, followed by oxidation as described above.
The peptides are also synthesized using an automatic synthesizer. Amino acids are sequentially coupled to an MBHA Rink resin (typically 100 mg of resin) beginning at the C-terminus using an Advanced Chemtech 357 Automatic Peptide Synthesizer.
Couplings are carried out using 1,3-diisopropylcarbodimide in N-methylpyrrolidinone (NMP) or by 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) and diethylisopro-pylethylamine (DIEA). The FMOC protecting group is removed by treatment with a 20% solution of piperidine in dimethylformamide(DMF). Resins are subsequently washed with DMF (twice), followed by methanol and NMP.
Pharmaceutical compositions containing a compound of the present invention or its pharmaceutically acceptable salts as the active ingredient can be prepared according to conventional pharmaceutical compounding techniques. See, for example, Remington's Pharmaceutical Sciences, 18th Ed. (1990, Mack Publishing Co., Easton, PA). Typically, an antagonistic amount of the active ingredient will be admixed with a pharmaceutically acceptable carrier. The carrier may take a wide variety of forms depending on the form of preparation desired for administration, e.g., intravenous, oral or parenteral. The compositions may further contain antioxidizing agents, stabilizing agents, preservatives and the like.
For oral administration, the compounds can be formulated into solid or liquid preparations such as capsules, pills, tablets, lozenges, melts, powders, suspensions or emulsions. In preparing the compositions in oral dosage form, any of the usual pharmaceutical media may be employed, such as, for example, water, glycols, oils, alcohols, flavoring agents, preservatives, coloring agents, suspending agents, and the like in the case of oral liquid preparations (such as, for example, suspensions, elixirs and solutions); or carriers such as starches, sugars, diluents, granulating agents, lubricants, binders, disintegrating agents and the like in the case of oral solid preparations (such as, for example, powders, capsules and tablets). Because of their ease in administration, tablets and capsules represent the most advantageous oral dosage unit form, in which case solid pharmaceutical carriers are obviously employed. If desired, tablets may be sugar-coated or enteric-coated by standard techniques. The active agent can be encapsulated to make it stable to passage through the gastrointestinal tract while at the same time allowing for passage across the blood brain barrier. See for example, WO 96/11698.
For parenteral administration, the compound may be dissolved in a pharmaceutical carrier and administered as either a solution or a suspension. Illustrative of suitable carriers are water, saline, dextrose solutions, fructose solutions, ethanol, or oils of animal, vegetative or synthetic origin. The carrier may also contain other ingredients, for example, preservatives, suspending agents, solubilizing agents, buffers and the like. When the compounds are being administered intrathecally, they may also be dissolved in cerebrospinal fluid.

The active agent is preferably administered in an therapeutically effective amount. The actual amount administered, and the rate and time-course of administration, will depend on the nature and severity of the condition being treated. Prescription of treatment, e.g. decisions on dosage, timing, etc., is within the responsibility of general practitioners or spealists, and typically takes account of the disorder to be treated, the condition of the individual patient, the site of delivery, the method of administration and other factors known to practitioners. Examples of techniques and protocols can be found in Remington's Parmaceutical Sciences.
Typically the conopeptides of the present invention exhibit their effect at a dosage range from about 0.001 mg/kg to about 250 mg/kg, preferably from about 0.05 mg/kg to about 100 mg/kg of the active ingredient, more preferably from a bout 0.1 mg/kg to about 75 mg/kg. A suitable dose can be administered in multiple sub-doses per day. Typically, a dose or sub-dose may contain from about 0.1 mg to about 500 mg of the active ingredient per unit dosage form. A more preferred dosage will contain from about 0.5 mg to about 100 mg of active ingredient per unit dosage form.
Dosages are generally initiated at lower levels and increased until desired effects are achieved.

Alternatively, targeting therapies may be used to deliver the active agent more specifically to certain types of cell, by the use of targeting systems such as antibodies or cell specific ligands.
Targeting may be desirable for a variety of reasons, e.g. if the agent is unacceptably toxic, or if it would otherwise require too high a dosage, or if it would not otherwise be able to enter the target cells.
The active agents, which are peptides, can also be administered in a cell based delivery system in which a DNA sequence encoding an active agent is introduced into cells designed for implantation in the body of the patient, especially in the spinal cord region.
Suitable delivery systems are described in U.S. Patent No. 5,550,050 and published PCT
Application Nos. WO
92/19195, WO 94/25503, WO 95/01203, WO 95/05452, WO 96/02286, WO 96/02646, WO
96/40871, WO 96/40959 and WO 97/12635. Suitable DNA sequences can be prepared synthetically for each active agent on the basis of the developed sequences and the known genetic code.

EXAMPLES
The present invention is described by reference to the following Examples, which are offered by way of illustration and are not intended to limit the invention in any manner.
Standard techniques well known in the art or the techniques specifically described below were utilized.

Isolation of a-Conotoxins Crude venom was extracted from venom ducts (Cruz et al., 1976), and the components were purified as previously described (Cartier et al., 1996a). The crude extract from venom ducts was purified by reverse phase liquid chromatography (RPLC) using a Vydac* C18 semi-preparative column (10 x 250 mm) and elution with a linear gradient of acetonitrile in 0.1 %TFA. Further purification of bioactive peaks was done on a Vydac C18 analytical column (4.6 x 220 mm) eluted with a gradient of acetonitrile in 0.1% TFA. The effluents were monitored at 220 nm. Peaks were collected, and aliquots were assayed for activity. Activity was monitored by assessing block of OP 4 nAChRs expressed in Xenopus oocytes.

The amino acid sequence of the purified peptides were determined by standard methods. The purified peptides were reduced and alkylated prior to sequencing by automated Edman degradation on an Applied Biosystems 477A Protein Sequencer with a 120A
Analyzer (DNA/Peptide Facility, University of Utah) (Martinez et al., 1995;
Shon et al., 1994).

In accordance with this method, peptides MII, AuIA, AuIB, AuIC, MAR-1, MAR-2, TI, OB- 29, Epl, S1.1, Bnl.1, Bnl.2, Cal.l, Cal.2, Cnl.l, Cnl.2 and Sml.3 were obtained.

* Trademark 30a Synthesis of Conopeptides The synthesis of conopeptides, either the mature toxins or the precursor peptides, was separately performed using conventional protection chemistry as described by Cartier et al. (1996). Briefly, the linear chains were built on Rink amide resin by Fmoc procedures with 2-(1H-benzotriol-l-yl)-1,1,3,3,-tetramethyluronium tetrafluoroborated coupling using an ABI
model 430A peptide sythesizer with amino acid derivatives purchased from Bachem (Torrence CA). Orthogonal protection was used on cysteines: Cys3 and Cys16 were protected as the stable Cys(S-acetamidomethyl), while Cyst and Cys8 were protected as the acid-labile Cys (S-trityl). After removal of the terminal Fmoc protecting group and cleavage of the peptides from the resins, the released peptides were precipitated by filtering the reaction mixture into -10 C methyl t-butyl ether, which removed the protecting groups except on Cys3 and Cys16. The peptides were dissolved in 0.1% TFA and 60% acetonitrile and purified by RPLC on a Vydac C18 preparative column (22 x 250 mm) and eluted at a flow rate of 20 mL/min with a gradient of acetonitrile in 0.1 % TFA.

The disulfide bridges in the three conopeptides were formed as described in Cartier et al.
(1996). Briefly, the disulfide bridges between Cyst and Cys8 were formed by air oxidation which was judged to be complete by analytical RPLC. The monocyclic peptides were purified by RPLC
on a Vydac C18 prepartive column (22 x 250 mm) and eluted with a gradient of acetonitrile in 0.1%
TFA. Removal of S-acetamidomethyl groups and closure of the disulfide bridge between Cys3 and Cys16 was carried out simultaneously be iodine oxidation. The cyclic peptides were purified by RPLC on a Vydac C18 prepartive column (22 x 250 mm) and eluted with a gradient of acetonitrile in 0.1 % TFA.

Isolation of DNA Encoding a-Conotoxins DNA coding for a-conotoxins was isolated and cloned in accordance with conventional techniques using general procedures well known in the art, such as described in Olivera et al. (1996).
Alternatively, cDNA libraries was prepared from Conus venom duct using conventional techniques.
DNA from single clones was amplified by conventional techniques using primers which correspond approximately to the M13 universal priming site and the M13 reverse universal priming site. Clones having a size of approximately 300 nucleotides were sequenced and screened for similarity in sequence to known a-conotoxins. The DNA sequences and encoded propeptide or peptide sequences are set forth in Tables 1-134.

DNA Sequence (SEQ ID NO:58) and Protein Sequence (SEQ ID NO:59) of MII
atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat cgt gca tct gat ggc agg aat gcc gca gcc aac gac Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp aaa gcg tct gac gtg atc acg ctg gcc ctc aag gga tgc tgt tcc aac Lys Ala Ser Asp Val Ile Thr Leu Ala Leu Lys Gly Cys Cys Ser Asn cct gtc tgt cac ttg gag cat tca aac ctt tgt ggt aga aga cgc Pro Val Cys His Leu Glu His Ser Asn Leu Cys Gly Arg Arg Arg tgatgctcca ggaccctctg aaccacgacg ttcgagca DNA Sequence (SEQ ID NO:60) and Protein Sequence (SEQ ID NO:61) of AuIA
atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca tct gat ggc agg aag gac gca gcg tct ggc Phe Thr Ser Asp Arg Ala Ser Asp Gly Arg Lys Asp Ala Ala Ser Gly ctg atc get ctg acc atc aag gga tgc tgt tct tat cct ccc tgt ttc Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser Tyr Pro Pro Cys Phe gcg act aat tca gac tat tgt ggt tgacgacgct gatgctccag gaccctctga Ala Thr Asn Ser Asp Tyr Cys Gly accacgacgt TABLE
DNA Sequence (SEQ ID NO:62) and Protein Sequence (SEQ ID NO:63) of AuIB
atg ttc acc gtg ttt ctg ttg gtc gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca tct gat ggc agg aag gac gca gcg tct ggc Phe Thr Ser Asp Arg Ala Ser Asp Gly Arg Lys Asp Ala Ala Ser Gly ctg att get ctg acc atg aag gga tgc tgt tct tat cct ccc tgt ttc Leu Ile Ala Leu Thr Met Lys Gly Cys Cys Ser Tyr Pro Pro Cys Phe gcg act aat cca gac tgt ggt cga cga cgc tgatgctcca ggaccctctg Ala Thr Asn Pro Asp Cys Gly Arg Arg Arg aaccacgacg t DNA Sequence (SEQ ID NO:64) and Protein Sequence (SEQ ID NO:65) of Tx1.3 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc tct tca ggt cgt agt aca ttt cgt ggc agg aat gcc gca gcc aaa Phe Ser Ser Gly Arg Ser Thr Phe Arg Gly Arg Asn Ala Ala Ala Lys gcg tct ggc ctg gtc agt ctg act gac agg aga cca gaa tgc tgt agt Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Glu Cys Cys Ser gat cct cgc tgt aac tcg agt cat cca gaa ctt tgt ggt gga aga cgc Asp Pro Arg Cys Asn Ser Ser His Pro Glu Leu Cys Gly Gly Arg Arg tgatgctcca ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:66) and Protein Sequence (SEQ ID NO:67) of Tx1.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc gcc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Ala Val Val Ser ttc act tca gat cgt gca tct gat gac ggg aaa gcc get gcg tct gac Phe Thr Ser Asp Arg Ala Ser Asp Asp Gly Lys Ala Ala Ala Ser Asp ctg atc act ctg acc atc aag gga tgc tgt tct cgt cct ccc tgt atc Leu Ile Thr Leu Thr Ile Lys Gly Cys Cys Ser Arg Pro Pro Cys Ile gcg aat aat cca gac ttg tgt ggt tgacgacgct gatgctccag aacggtctga Ala Asn Asn Pro Asp Leu Cys Gly accacgacgt tcgagcaatg ttcaccgtgt ttctgttggt tgtctt DNA Sequence (SEQ ID NO:68) and Protein Sequence (SEQ ID NO:69) of Txl.1 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt agt aca ttt cgt ggc agg aat gcc gca gcc aaa Phe Thr Ser Gly Arg Ser Thr Phe Arg Gly Arg Asn Ala Ala Ala Lys gcg tct ggc ctg gtc agt ctg act gac agg aga cca caa tgc tgt tct Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Gln Cys Cys Ser cat cct gcc tgt aac gta gat cat cca gaa att tgt cgt tgaagacgct His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Arg gatgctccag gaccctctga accacgacgt DNA Sequence (SEQ ID NO:70) and Protein Sequence (SEQ ID NO:71) of R1.1A
atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt cgt aca ttt cat ggc agg aat gcc gca gcc aaa Phe Thr Ser Gly Arg Arg Thr Phe His Gly Arg Asn Ala Ala Ala Lys gcg tct ggc ctg gtc agt ctg act gac agg aga cca gaa tgc tgt tct Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Glu Cys Cys Ser cat cct gcc tgt aac gta gat cat cca gaa att tgt cgt tgaagacgct His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Arg gatgctccag gaccctctga accacgacgt DNA Sequence (SEQ ID NO:72) and Protein Sequence (SEQ ID NO:73) of R1.1B
atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt agt aca ttt cgt ggc agg aat gcc gca gcc aaa Phe Thr Ser Gly Arg Ser Thr Phe Arg Gly Arg Asn Ala Ala Ala Lys gcg tct ggc ctg gtc agt ctg act gac agg aga cca caa tgc tgt tct Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Gin Cys Cys Ser cat cct gcc tgt aac gta gat cat cca gaa att tgc gat tgaagacgct His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Asp gatgctccag gaccctctga accacgacgt DNA Sequence (SEQ ID NO:74) and Protein Sequence (SEQ ID NO:75) of S1.1 atg ttc act gtg ttt ctg ttg gtt gtc ttg gca atc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Ile Thr Val Val Ser ttc cct tta gat cgt gaa tct gat ggc gcg aat gcc gaa gcc cgc acc Phe Pro Leu Asp Arg Glu Ser Asp Gly Ala Asn Ala Glu Ala Arg Thr cac gat cat gag aag cac gca ctg gac cgg aat gga tgc tgt agg aat His Asp His Glu Lys His Ala Leu Asp Arg Asn Gly Cys Cys Arg Asn cct gcc tgt gag agc cac aga tgt ggt tgacgacgct gatgctccag Pro Ala Cys Glu Ser His Arg Cys Gly gaccctctga accacgacgt tcgagca DNA Sequence (SEQ ID NO:76) and Protein Sequence (SEQ ID NO:77) of Bnl.1 atg ttc acc atg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Met Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc get tca gat cgt gca tct gat ggc agg aat gcc gca gcc aag gac Phe Ala Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Lys Asp aaa gcg tct gac ctg gtc get ctg acc gtc aag gga tgc tgt tct cat Lys Ala Ser Asp Leu Val Ala Leu Thr Val Lys Gly Cys Cys Ser His cct gcc tgt agc gtg aat aat cca gac att tgt ggt tgaagacgct Pro Ala Cys Ser Val Asn Asn Pro Asp Ile Cys Gly gatgctccag gaccctctga accacgacgt tcgagca DNA Sequence (SEQ ID NO:78) and Protein Sequence (SEQ ID NO:79) of Bnl.2 aaa gaa tgc tgt act cat cct gcc tgt cac gtg agt cat cca gaa ctc Lys Glu Cys Cys Thr His Pro Ala Cys His Val Ser His Pro Glu Leu tgt ggt tgaaaagcga cgtgacgctc caggaccctc tgaaccacga cgttcgagca Cys Gly DNA Sequence (SEQ ID NO:80) and Protein Sequence (SEQ ID NO:81) of Bnl.3 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca act get gtt ctt cca Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Ala Val Leu Pro 5 gtc act tta gat cgt gca tct gat gga agg aat gca gca gcc aac gcc Val Thr Leu Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala aaa acg cct cgc ctg atc gcg cca ttc atc agg gat tat tgc tgt cat Lys Thr Pro Arg Leu Ile Ala Pro Phe Ile Arg Asp Tyr Cys Cys His aga ggt ccc tgt atg gta tgg tgt ggt tgaagccgct gctgctccag 10 Arg Gly Pro Cys Met Val Trp Cys Gly gaccctctga accac DNA Sequence (SEQ ID NO:82) and Protein Sequence (SEQ ID NO:83) of Cal.1 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtg gtt tcc 15 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt get tct gat ggc agg aat gcc gca gcc aac gcg Phe Thr Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala ttt gac ctg atc get ctg atc gcc agg caa aat tgc tgt agc att ccc Phe Asp Leu Ile Ala Leu Ile Ala Arg Gln Asn Cys Cys Ser Ile Pro 20 agc tgt tgg gag aaa tat aaa tgt agt taa Ser Cys Trp Glu Lys Tyr Lys Cys Ser DNA Sequence (SEQ ID NO:84) and Protein Sequence (SEQ ID NO:85) of Cal.2 25 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtg gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gcg tct gaa ggc agg aat get gca gcc aag gac Phe Thr Ser Asp Arg Ala Ser Glu Gly Arg Asn Ala Ala Ala Lys Asp aaa gcg tct gac ctg gtg get ctg aca gtc agg gga tgc tgt gcc att 30 Lys Ala Ser Asp Leu Val Ala Leu Thr Val Arg Gly Cys Cys Ala Ile cgt gaa tgt cgc ttg cag aat gca gcg tat tgt ggt gga ata tac Arg Glu Cys Arg Leu Gln Asn Ala Ala Tyr Cys Gly Gly Ile Tyr .tgatgctcca ggaccctctg aaccacgacg 35 DNA Sequence (SEQ ID NO:86) and Protein Sequence (SEQ ID NO:87) of TIB
atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat att gca act gag ggc agg aat gcc gca gcc aaa gcg Phe Pro Ser Asp Ile Ala Thr Glu Gly Arg Asn Ala Ala Ala Lys Ala ttt gac ctg ata tct tcg atc gtc aag aaa gga tgc tgt tcc cat cct Phe Asp Leu Ile Ser Ser Ile Val Lys Lys Gly Cys Cys Ser His Pro gcc tgt tcg ggg aat aat cca gaa ttt tgt cgt caa ggt cgc Ala Cys Ser Gly Asn Asn Pro Glu Phe Cys Arg Gln Gly Arg tgatgctcca ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:88) and Protein Sequence (SEQ ID NO:89) of TIA
atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat ata gca act gag ggc agg aat gcc gca gcc aaa gcg Phe Pro Ser Asp Ile Ala Thr Glu Gly Arg Asn Ala Ala Ala Lys Ala ttt gac ctg ata tct tcg atc gtc agg aaa gga tgc tgt tcc aat ccc Phe Asp Leu Ile Ser Ser Ile Val Arg Lys Gly Cys Cys Ser Asn Pro gcc tgt gcg ggg aat aat cca cat gtt tgt cgt caa ggt cgc Ala Cys Ala Gly Asn Asn Pro His Val Cys Arg Gln Gly Arg tgatgctcca ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:90) and Protein Sequence (SEQ ID NO:91) of Sll.1 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc aat tca gat cgt gat cca gca tta ggt ggc agg aat get gca gcc Phe Asn Ser Asp Arg Asp Pro Ala Leu Gly Gly Arg Asn Ala Ala Ala aaa gcg tct gac aag atc get tcg acc ctc aag aga aga gga tgc tgt Lys Ala Ser Asp Lys Ile Ala Ser Thr Leu Lys Arg Arg Gly Cys Cys tcg tat ttt gac tgt aga atg atg ttt cca gaa atg tgt ggt tgg cga Ser Tyr Phe Asp Cys Arg Met Met Phe Pro Glu Met Cys Gly Trp Arg ggc tgatgctcca ggaccctctg aaccacgacg t Gly DNA Sequence (SEQ ID NO:92) and Protein Sequence (SEQ ID NO:93) of S11.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc aat tca gat cgt gat cca gca tta ggt ggc agg aat get gca gcc Phe Asn Ser Asp Arg Asp Pro Ala Leu Gly Gly Arg Asn Ala Ala Ala ata gcg tct gac aag atc get tcg acc ctc agg aga gga gga tgc tgt Ile Ala Ser Asp Lys Ile Ala Ser Thr Leu Arg Arg Gly Gly Cys Cys tct ttt cct gcc tgt aga aag tat cgt cca gaa atg tgt ggt gga cga Ser Phe Pro Ala Cys Arg Lys Tyr Arg Pro Glu Met Cys Gly Gly Arg cgc tgatgctcca ggaccctctg aaccacgacg t Arg DNA Sequence (SEQ ID NO:94) and Protein Sequence (SEQ ID NO:95) of S11.3 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cat gaa tct gat cgc ggt gat gcc caa acc atc caa Phe Thr Ser Asp His Glu Ser Asp Arg Gly Asp Ala Gln Thr Ile Gln gaa gtg ttt gag atg ttc get ctg gac agc gat gga tgc tgt tgg cat Glu Val Phe Glu Met Phe Ala Leu Asp Ser Asp Gly Cys Cys Trp His cct get tgt ggc aga cac tat tgt ggt cga aga cgc tgatgctcca Pro Ala Cys Gly Arg His Tyr Cys Gly Arg Arg Arg ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:96) and Protein Sequence (SEQ ID NO:97) of S11.6 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc aat tca gat cgt gat cca gca tta ggt ggc agg aat get gca gcc Phe Asn Ser Asp Arg Asp Pro Ala Leu Gly Gly Arg Asn Ala Ala Ala ata gcg tct gac aag atc get tcg acc ctc agg aga gga gga tgc tgt Ile Ala Ser Asp Lys Ile Ala Ser Thr Leu Arg Arg Gly Gly Cys Cys tct ttt get gcc tgt aga aag tat cgt cca gaa atg tgt ggt gga cga Ser Phe Ala Ala Cys Arg Lys Tyr Arg Pro Glu Met Cys Gly Gly Arg cgc tgatgct Arg DNA Sequence (SEQ ID NO:98) and Protein Sequence (SEQ ID NO:99) of S11.7 atg ttc acc gtg ttt ctg ttg gtt ctc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Leu Leu Ala Thr Thr Val Val Ser ttc aat tca gat cgt gca tta ggt ggc agg aat get gca gcc aaa gcg Phe Asn Ser Asp Arg Ala Leu Gly Gly Arg Asn Ala Ala Ala Lys Ala tct gac aag atc ctt tcg aac ctc agg aga gga gga tgc tgt ttt cat Ser Asp Lys Ile Leu Ser Asn Leu Arg Arg Gly Gly Cys Cys Phe His cct gtc tgt tac atc aat ctt cta gaa atg tgt cgt caa cga ggc Pro Val Cys Tyr Ile Asn Leu Leu Glu Met Cys Arg Gln Arg Gly tgatcgtcca ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:100) and Protein Sequence (SEQ ID NO:101) of Cn1.1 atg ttc acc gtg ttt ctg ttg gtt gtc ttg aca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Thr Thr Thr Val Val Ser ttc cct tca gat agt gca tct gat gtc agg gat gac gaa gcc aaa gac Phe Pro Ser Asp Ser Ala Ser Asp Val Arg Asp Asp Glu Ala Lys Asp gaa agg tct gac atg tac aaa tcg aaa cgg aat gga cgc tgt tgc cat Glu Arg Ser Asp Met Tyr Lys Ser Lys Arg Asn Gly Arg Cys Cys His cct gcc tgt ggc aaa cac ttt agt tgt gga cgc tgatgctcca ggaccctctg Pro Ala Cys Gly Lys His Phe Ser Cys Gly Arg aaccacgacg t DNA Sequence (SEQ ID NO: 102) and Protein Sequence (SEQ ID NO: 103) of SmI
atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser tcc cct tca gat cgt gca tct gat ggc agg aat gcc gca gcc aac gag Ser Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Glu aaa gcg tct gac gtg atc gcg ctg gcc ctc aag gga tgc tgt tcc aac Lys Ala Ser Asp Val Ile Ala Leu Ala Leu Lys Gly Cys Cys Ser Asn cct gtc tgt cac ctg gag cat tca aac atg tgt ggt aga aga cgc Pro Val Cys His Leu Glu His Ser Asn Met Cys Gly Arg Arg Arg tgatgctcca ggaccctctg aaccacgacg DNA Sequence (SEQ ID NO:104) and Protein Sequence (SEQ ID NO: 105) of Bt 1. 1 atg ttc tcc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Ser Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser tcc act tca ggt ggt gca tct ggt ggc agg aag get gca gcc aaa gcg Ser Thr Ser Gly Gly Ala Ser Gly Gly Arg Lys Ala Ala Ala Lys Ala tct aac cgg atc get ctg acc gtc agg agt gca aca tgc tgt aat tat Ser Asn Arg Ile Ala Leu Thr Val Arg Ser Ala Thr Cys Cys Asn Tyr cct ccc tgt tac gag act tat cca gaa agt tgt ctg taacgtgaat Pro Pro Cys Tyr Glu Thr Tyr Pro Glu Ser Cys Leu catccagagc tttgtggctg aagacactga tgctccagga ccctctgaac cacgacgt DNA Sequence (SEQ ID NO:106) and Protein Sequence (SEQ ID NO:107) of Bt1.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtg gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt gca ttt cgt ggc agg aat cgc gca gcc gac gac Phe Thr Ser Gly Arg Ala Phe Arg Gly Arg Asn Arg Ala Ala Asp Asp aaa agg tct gac ctg gcc get ctg agc gtc agg gga gga tgc tgt tcc Lys Arg Ser Asp Leu Ala Ala Leu Ser Val Arg Gly Gly Cys Cys Ser cat cct gcc tgt gcg gtg aat cat cca gag ctt tgt ggc tgaagacgct His Pro Ala Cys Ala Val Asn His Pro Glu Leu Cys Gly gatgccccag gaccctctga accacgacgt DNA Sequence (SEQ ID NO:108) and Protein Sequence (SEQ ID NO:109) of Bt1.3 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt gca tct ggt ggc agg aat get gca gcc aaa gcg She Thr Ser Gly Arg Ala Ser Gly Gly Arg Asn Ala Ala Ala Lys Ala tct aac cgg atc get atg gcc atc agc agt gga gca tgc tgt gca tat Ser Asn Arg Ile Ala Met Ala Ile Ser Ser Gly Ala Cys Cys Ala Tyr cct ccc tgt ttc gag get tat cca gaa aga tgt ctg taacgtgaat Pro Pro Cys Phe Glu Ala Tyr Pro Glu Arg Cys Leu catccagacc tttgtggctg aagacgctga tgccccagga ccctctgaac cacgacgt DNA Sequence (SEQ ID NO:110) and Protein Sequence (SEQ ID NO:111) of Bt1.4 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met She Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca ttt cgt ggc agg aat tcc gca gcc aac gac Phe Thr Ser Asp Arg Ala Phe Arg Gly Arg Asn Ser Ala Ala Asn Asp aaa agg tct gac ctg gcc get ctg agc gtc agg aga gga tgc tgc tcc Lys Arg Ser Asp Leu Ala Ala Leu Ser Val Arg Arg Gly Cys Cys Ser cat ccc gcc tgt agc gtg aat cat cca gag ctt tgt ggt aga aga cgc His Pro Ala Cys Ser Val Asn His Pro Glu Leu Cys Gly Arg Arg Arg tgatgcccca ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO: 112) and Protein Sequence (SEQ ID NO:1 13) of Bt1.5 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met She Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt gca tct ggt ggc agg aat get gca gcc aaa gcg She Thr Ser Gly Arg Ala Ser Gly Gly Arg Asn Ala Ala Ala Lys Ala tct aac cgg atc get ctg atc gtc agg aat gca gaa tgc tgt tat tat Ser Asn Arg Ile Ala Leu Ile Val Arg Asn Ala Glu Cys Cys Tyr Tyr cct ccc tgt tac gag get tat cca gaa att tgt ctg taacgtgaat Pro Pro Cys Tyr Glu Ala Tyr Pro Glu Ile Cys Leu catccagacc tttgtggctg aagaccctga tgctccagga ccctctgaac cacgacgt 5 DNA Sequence (SEQ ID NO: 114) and Protein Sequence (SEQ ID NO: 115) of Pn1.1 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc att tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Ile Ser ttc act tca gat cgt gca tct gat ggc ggg aat gcc gca gcg tct gac Phe Thr Ser Asp Arg Ala Ser Asp Gly Gly Asn Ala Ala Ala Ser Asp 10 ctg atc.gct ctg acc atc aag gga tgc tgt tct cat cct ccc tgt gcc Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser His Pro Pro Cys Ala atg aat aat cca gac tat tgt ggt tgacgacgct gatgctccag gaccctctga Met Asn Asn Pro Asp Tyr Cys Gly accacgacg DNA Sequence (SEQ ID NO: 116) and Protein Sequence (SEQ ID NO: 117) of Pn1.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca tct gat ggc ggg aat gcc gca atg tct gac 20 Phe Thr Ser Asp Arg Ala Ser Asp Gly Gly Asn Ala Ala Met Ser Asp ctg atc get ctg acc atc aag gga tgc tgt tct cat cct ccc tgt ttc Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser His Pro Pro Cys Phe ctg aat aat cca gac tat tgt ggt tgacgacgct gatgctccag gaccctctga Leu Asn Asn Pro Asp Tyr Cys Gly 25 accacgacg DNA Sequence (SEQ ID NO: 118) and Protein Sequence (SEQ ID NO: 119) of SmI.3 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser 30 ttc cct tca gat cgt gaa tct gat ggc gcg aat gac gaa gcc cgc acc Phe Pro Ser Asp Arg Glu Ser Asp Gly Ala Asn Asp Glu Ala Arg Thr gac gag cct gag gag cac gga ccg gac agg aat gga tgc tgt agg aat Asp Glu Pro Glu Glu His Gly Pro Asp Arg Asn Gly Cys Cys Arg Asn cct gcc tgt gag agc cac aga tgt ggt tgacgacgct gatgctccag 35 Pro Ala Cys Glu Ser His Arg Cys Gly gaccctctga accacgacg DNA Sequence (SEQ ID NO:120) and Protein Sequence (SEQ ID NO:121) of Cr1.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat cgt gca tct gat ggc agg aat gcc gca gcc agc gac Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Ser Asp aga gcg tct gac gcg gcc cac cag gga tgc tgt tcc aac cct gtc tgt Arg Ala Ser Asp Ala Ala His Gln Gly Cys Cys Ser Asn Pro Val Cys cac gtg gaa cat cca gaa ctt tgt cgt aga aga cgc tgatgctcca His Val Glu His Pro Glu Leu Cys Arg Arg Arg Arg ggaccctctg aaccacgacg DNA Sequence (SEQ ID NO:122) and Protein Sequence (SEQ ID NO: 123) of CrI.3 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca aat cgt gaa tct gat ggc gcg aat gcc gaa gtc cgc acc Phe Pro Ser Asn Arg Glu Ser Asp Gly Ala Asn Ala Glu Val Arg Thr gac gag cct gag gag cac gac gaa ctg ggc ggg aat gga tgc tgt ggg Asp Glu Pro Glu Glu His Asp Glu Leu Gly Gly Asn Gly Cys Cys Gly aat cct gac tgt acg agc cac agt tgt gat tgacgacgct gatgctccag Asn Pro Asp Cys Thr Ser His Ser Cys Asp gaccctctga accacgacg DNA Sequence (SEQ ID NO:124) and Protein Sequence (SEQ ID NO:125) of EpI
atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca tct gat agc agg aag gac gca gcg tct ggc Phe Thr Ser Asp Arg Ala Ser Asp Ser Arg Lys Asp Ala Ala Ser Gly ctg atc get ctg acc atc aag gga tgc tgt tct gat cct cgc tgt aac Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser Asp Pro Arg Cys Asn atg aat aat cca gac tat tgt ggt tgacgacgct gatgctccag gaccctctga Met Asn Asn Pro Asp Tyr Cys Gly accacgacg DNA Sequence (SEQ ID NO:126) and Protein Sequence (SEQ ID NO:127) of Sn1.1 atg tcc acc gtg ttt ctg ttg gtt gtc ctc gca acc acc gtc gtt tcc Met Ser Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act gta gat cgt gca tct gat ggc agg gat gtc gca atc gac gac Phe Thr Val Asp Arg Ala Ser Asp Gly Arg Asp Val Ala Ile Asp Asp aga ttg gtg tct ctc cct cag atc gcc cat get gac tgt tgt tcc gat Arg Leu Val Ser Leu Pro Gln Ile Ala His Ala Asp Cys Cys Ser Asp cct gcc tgc aag cag acg ccc ggt tgt cgt taaagacgct gctgctccag Pro Ala Cys Lys Gln Thr Pro Gly Cys Arg gaccctctga accacgacg DNA Sequence (SEQ ID NO:128) and Protein Sequence (SEQ ID NO:129) of Snl.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc get tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Ala Ser ttc att atc gat gat cca tct gat ggc agg aat att gca gtc gac gac Phe Ile Ile Asp Asp Pro Ser Asp Gly Arg Asn Ile Ala Val Asp Asp aga ggg ctt ttc tct acg ctc ttc cat get gat tgc tgt gaa aat cct Arg Gly Leu Phe Ser Thr Leu Phe His Ala Asp Cys Cys Glu Asn Pro gcc tgt aga cac acg cag ggt tgt tgatctttgt tcttcaaaga cactgctggc Ala Cys Arg His Thr Gln Gly Cys ccaggaccct ctgaaccacg acg DNA Sequence (SEQ ID NO:130) and Protein Sequence (SEQ ID NO:131) of Dal.1 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca ttt cgt ggc agg aat gcc gca gcc aaa gag Phe Thr Ser Asp Arg Ala Phe Arg Gly Arg Asn Ala Ala Ala Lys Glu tct ggc ctg gtc ggt ctg acc gac aag acg cga gga tgc tgt tct cat Ser Gly Leu Val Gly Leu Thr Asp Lys Thr Arg Gly Cys Cys Ser His cct gcc tgt aac gta gat cat cca gaa att tgt ggt tgaagacgct Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Gly gatgctccag gaccctctga accacgacgt DNA Sequence (SEQ ID NO:132) and Protein Sequence (SEQ ID NO:133) of Dal.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat ggt gca tct gat gac agg aaa gcc get gcg tct gac Phe Thr Ser Asp Gly Ala Ser Asp Asp Arg Lys Ala Ala Ala Ser Asp ctg atc act ctg acc atc aag gga tgc tgt tct cgt cct ccc tgt atc Leu Ile Thr Leu Thr Ile Lys Gly Cys Cys Ser Arg Pro Pro Cys Ile gcg aat aat cca gac ttg tgt ggt cga cga cgc tgatgctcca ggaccctctg Ala Asn Asn Pro Asp Leu Cys Gly Arg Arg Arg DNA Sequence (SEQ ID NO:134) and Protein Sequence (SEQ ID NO:135) of Dal.3 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser tcc act tca ggt cgt cgt gca ttt cat ggc agg aat gcc gca gcc aaa Ser Thr Ser Gly Arg Arg Ala Phe His Gly Arg Asn Ala Ala Ala Lys gcg tct gga ctg gtc ggt ctg act gac agg aga cca caa tgc tgt agt Ala Ser Gly Leu Val Gly Leu Thr Asp Arg Arg Pro Gln Cys Cys Ser gat cct cgc tgt aac gta ggt cat cca gaa ctt tgt ggt gga aga cgc Asp Pro Arg Cys Asn Val Gly His Pro Glu Leu Cys Gly Gly Arg Arg tgatgctcca ggaccctctg aaccacaacg t DNA Sequence (SEQ ID NO:136) and Protein Sequence (SEQ ID NO:137) of Dal.4 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser tcc act tca ggt cgt gca ttt cat ggc agg aat gcc gca gcc aaa gcg Ser Thr Ser Gly Arg Ala Phe His Gly Arg Asn Ala Ala Ala Lys Ala tct ggc ctg gtc ggt ctg acc gac aag agg caa gta tgc tgt agt gat Ser Gly Leu Val Gly Leu Thr Asp Lys Arg Gln Val Cys Cys Her Asp cct cgc tgt aac gta ggt cat cca gaa att tgt ggt gga aga cgc Pro Arg Cys Asn Val Gly His Pro Glu Ile Cys Gly Gly Arg Arg tgatgctcca ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:138) and Protein Sequence (SEQ ID NO:139) of A1.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg aca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Thr Thr Thr Val Val Ser ttc cct tca gat agt gca tct ggt ggc agg gat gac gag gcc aaa gac Phe Pro Ser Asp Ser Ala Ser Gly Gly Arg Asp Asp Glu Ala Lys Asp gaa agg tct gac atg tac gaa ttg aaa cgg aat gga cgc tgt tgc cat Glu Arg Ser Asp Met Tyr Glu Leu Lys Arg Asn Gly Arg Cys Cys His cct gcc tgt ggt ggc aaa tac gtt aaa tgt gga cgc tgatgctcca Pro Ala Cys Gly Gly Lys Tyr Val Lys Cys Gly Arg ggaccctctc gaaccacg DNA Sequence (SEQ ID NO:140) and Protein Sequence (SEQ ID NO:141) of Bul.1 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc tct aca gat gat gaa tct gat ggc tcg aat gaa gaa ccc agc gcc Phe Ser Thr Asp Asp Glu Ser Asp Gly Ser Asn Glu Glu Pro Ser Ala gac cag act gcc agg tcc tca atg aac agg gcg cct gga tgc tgt aac Asp Gln Thr Ala Arg Ser Ser Met Asn Arg Ala Pro Gly.Cys Cys Asn aat cct gcc tgt gtg aag cac aga tgt gga tgacgctgat gctccaggac Asn Pro Ala Cys Val Lys His Arg Cys Gly cctctgaacc acgacgt DNA Sequence (SEQ ID NO:142) and Protein Sequence (SEQ ID NO:143) of Bul.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc tct aca gat gat gaa tct gat ggc tcg aat gaa gaa ccc agc gcc Phe Ser Thr Asp Asp Glu Ser Asp Gly Ser Asn Glu Glu Pro Ser Ala gac cag get gcc agg tcc gca atg aac agg ccg cct gga tgc tgt aac Asp Gln Ala Ala Arg Ser Ala Met Asn Arg Pro Pro Gly Cys Cys Asn aat cct gcc tgt gtg aag cac aga tgt ggt gga tgacgctgat gctccaggac Asn Pro Ala Cys Val Lys His Arg Cys Gly Gly cctctgaacc acgacgt DNA Sequence (SEQ ID NO:144) and Protein Sequence (SEQ ID NO:145) of Bul.3 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat cgt gac tct gat ggc gcg gat gcc gaa gcc agt gac Phe Pro Ser Asp Arg Asp Ser Asp Gly Ala Asp Ala Glu Ala Ser Asp gag cct gtt gag ttc gaa agg gac gag aat gga tgc tgt tgg aat cct Glu Pro Val Glu Phe Glu Arg Asp Glu Asn Gly Cys Cys Trp Asn Pro tcc tgt ccg agg ccc aga tgt aca gga cga cgc taatgctcca ggaccctctg Ser Cys Pro Arg Pro Arg Cys Thr Gly Arg Arg aaccacgacg t DNA Sequence (SEQ ID NO:146) and Protein Sequence (SEQ ID NO:170) of Bul.4 atg ttc acc gtg ttt ctg ttg gtt gtc ttg aca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Thr Thr Thr Val Val Ser ttc cct tca gat cgt gca tct gat ggc agg aat gcc gca gcc aac gac Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp aaa gcg tct gac gtg gtc acg ctg gtc ctc aag gga tgc tgt tcc acc Lys Ala Ser Asp Val Val Thr Leu Val Leu Lys Gly Cys Cys Ser Thr 5 cct ccc tgt get gtg ctg tat tgt ggt aga aga cgc tgatgctcca Pro Pro Cys Ala Val Leu Tyr Cys Gly Arg Arg Arg ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:148) and Protein Sequence (SEQ ID NO: 149) of Di 1. 1 10 atg ttc acc gtg ttt ctg ttg gtt gtc ttc gca tcc tct gtc acc tta Met Phe Thr Val Phe Leu Leu Val Val Phe Ala Ser Ser Val Thr Leu gat cgt gca tct tat ggc agg tat gcc tca ccc gtc gac aga gcg tct Asp Arg Ala Ser Tyr Gly Arg Tyr Ala Ser Pro Val Asp Arg Ala Ser gcc ctg atc get cag gcc atc ctt cga gat tgc tgc tcc aat cct cct 15 Ala Leu Ile Ala Gln Ala Ile Leu Arg Asp Cys Cys Ser Asn Pro Pro tgt gcc cat aat aat cca gac tgt cgt taaagacgct gcttgctcca Cys Ala His Asn Asn Pro Asp Cys Arg ggaccctctg aaccacgacg t 20 DNA Sequence (SEQ ID NO:150) and Protein Sequence (SEQ ID NO:151) of Ti gga tgc tgt tct aat cct ccc tgt atc gcg aag aat cca cac atg tgt Gly Cys Cys Ser Asn Pro Pro Cys Ile Ala Lys Asn Pro His Met Cys ggt gga aga cgc tga Gly Gly Arg Arg DNA Sequence (SEQ ID NO:152) and Protein Sequence (SEQ ID NO:153) of Cn1.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat cgt gca tct gat ggc agg aat gcc gca gcc aac gac 30 Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp aaa gcg tct gac gtg atc acg ctg gcc ctc aag gga tgc tgt tcc aac Lys Ala Ser Asp Val Ile Thr Leu Ala Leu Lys Gly Cys Cys Ser Asn cct gtc tgt cac ttg gag cat tca aac ctt tgt ggt aga aga cgc Pro Val Cys His Leu Glu His Ser Asn Leu Cys Gly Arg Arg Arg 35 tgatgctcca ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:233) and Protein Sequence (SEQ ID NO:234) of Iml.1 tct gat gga aag agt gcc gcg gcc aaa gcc aaa ccg tct cac ctg acg Ser Asp Gly Lys Ser Ala Ala Ala Lys Ala Lys Pro Ser His Leu Thr get cca ttc atc agg gac gaa tgc tgt tcc gat tct cgc tgt ggc aag Ala Pro Phe Ile Arg Asp Glu Cys Cys Ser Asp Ser Arg Cys Gly Lys aac tgt ctt tga Asn Cys Leu DNA Sequence (SEQ ID NO:235) and Protein Sequence (SEQ ID NO:236) of Iml.2 ttt gat gga agg aat gcc cca gcc gac gac aaa gcg tct gac ctg atc Phe Asp Gly Arg Asn Ala Pro Ala Asp Asp Lys Ala Ser Asp Leu Ile get caa atc gtc agg aga gca tgc tgt tcc gat cgt cgc tgt aga tgg Ala Gln Ile Val Arg Arg Ala Cys Cys Ser Asp Arg Arg Cys Arg Trp agg tgt ggt tga Arg Cys Gly DNA Sequence (SEQ ID NO:237) and Protein Sequence (SEQ ID NO:238) of Rg1.2 tct gat gga agg aat gcc gca gcc gac gcc aga gcg tct ccc cgg atc Ser Asp Gly Arg Asn Ala Ala Ala Asp Ala Arg Ala Ser Pro Arg Ile get ctt ttc ctc agg ttc aca tgc tgt agg aga ggt acc tgt tcc cag Ala Leu Phe Leu Arg Phe Thr Cys Cys Arg Arg Gly Thr Cys Ser Gln cac tgt ggt tgaagacact gctgctccag gaccctctga accacgacgt His Cys Gly DNA Sequence (SEQ ID NO:239) and Protein Sequence (SEQ ID NO:240) of Rg 1.6 tct aat gga agg aat gcc gca gcc gac gcc aaa gcg tct caa cgg atc Ser Asn Gly Arg Asn Ala Ala Ala Asp Ala Lys Ala Ser Gln Arg Ile get cca ttc ctc agg gac tat tgc tgt agg aga cat gcc tgt acg ttg Ala Pro Phe Leu Arg Asp Tyr Cys Cys Arg Arg His Ala Cys Thr Leu att tgt ggt tgaagacgct gctgctccag gaccctctga accacgacgt Ile Cys Gly DNA Sequence (SEQ ID NO:241) and Protein Sequence (SEQ ID NO:242) of Rgl.6A
tct aat gga agg aat gcc gca gcc gac gcc aaa gcg tct caa cgg atc Ser Asn Gly Arg Asn Ala Ala Ala Asp Ala Lys Ala Ser Gln Arg Ile get cca ttc ctc agg gac tat tgc tgt agg aga cct ccc tgt acg ttg Ala Pro Phe Leu Arg Asp Tyr Cys Cys Arg Arg Pro Pro Cys Thr Leu att tgt ggt tgaagacgct gctgctccag gaccctctga accacgacgt Ile Cys Gly DNA Sequence (SEQ ID NO:243) and Protein Sequence (SEQ ID NO:244) of Rg1.7 tct aat aaa agg aag aat gcc gca atg ctt gac atg atc get caa cac Ser Asn Lys Arg Lys Asn Ala Ala Met Leu Asp Met Ile Ala Gln His gcc ata agg ggt tgc tgt tcc gat cct cgc tgt aga tat aga tgt cgt Ala Ile Arg Gly Cys Cys Ser Asp Pro Arg Cys Arg Tyr Arg Cys Arg tgaagacgct gctgctccag gaccctctga accacgacgt DNA Sequence (SEQ ID NO:245) and Protein Sequence (SEQ ID NO:246) of Rg1.9 ttt aat gga agg agt gcc gca gcc gac caa aat gcg cct ggc ctg atc Phe Asn Gly Arg Ser Ala Ala Ala Asp Gln Asn Ala Pro Gly Leu Ile get caa gtc gtc aga gga ggg tgc tgt tcc gat ccc cgc tgc gcc tgg Ala Gln Val Val Arg Gly Gly Cys Cys Ser Asp Pro Arg Cys Ala Trp aga tgt ggt tgaagacgtt gctgctccag gaccctctga accacgacgt Arg Cys Gly DNA Sequence (SEQ ID NO:247) and Protein Sequence (SEQ ID NO:248) of Rg1.10 ttt gat gga agg aat gcc gca gcc gac gcc aaa gtg att aac acg gtc Phe Asp Gly Arg Asn Ala Ala Ala Asp Ala Lys Val Ile Asn Thr Val get cga atc gcc tgg gat ata tgc tgt tcc gaa cct gac tgt aac cat Ala Arg Ile Ala Trp Asp Ile Cys Cys Ser Glu Pro Asp Cys Asn His aaa tgt gtt tgaagacgct tctgctccag gaccctctga accacgacgt Lys Cys Val DNA Sequence (SEQ ID NO:249) and Protein Sequence (SEQ ID NO:250) of Rg1.11 tct aat aaa agg aag aat gcc gca atg ctt gac atg atc get caa cac Ser Asn Lys Arg Lys Asn Ala Ala Met Leu Asp Met Ile Ala Gln His gcc ata agg ggt tgc tgt tcc gat cct cgc tgt aaa cat cag tgt ggt Ala Ile Arg Gly Cys Cys Ser Asp Pro Arg Cys Lys His Gln Cys Gly tgaagacgct gctgctccag gaccctctga accacgacgt DNA Sequence (SEQ ID NO:251) and Protein Sequence (SEQ ID NO:252) of Msl .7 atc aag aat aca gca gcc agc aac aaa gcg tct agc ctg gtg get ctt Ile Lys Asn Thr Ala Ala Ser Asn Lys Ala Ser Ser Leu Val Ala Leu gtt gtc agg gga tgc tgt tac aat cct gtc tgc aag aaa tat tat tgt Val Val Arg Gly Cys Cys Tyr Asn Pro Val Cys Lys Lys Tyr Tyr Cys tgg aaa ggc tgatgctcca ggaccctctg aaccacgacg t Trp Lys Gly DNA Sequence (SEQ ID NO:253) and Protein Sequence (SEQ ID NO:254) of P1.7 tct gaa ggc agg aat get gaa gcc atc gac aac gcc tta gac cag agg Ser Glu Gly Arg Asn Ala Glu Ala Ile Asp Asn Ala Leu Asp Gln Arg gat cca aag cga cag gag ccg ggg tgc tgt agg cat cct gcc tgt ggg Asp Pro Lys Arg Gln Glu Pro Gly Cys Cys Arg His Pro Ala Cys Gly aag aac aga tgt gga aga cgc tgatgctcca ggaccctctg aaccacgacg t Lys Asn Arg Cys Gly Arg Arg DNA Sequence (SEQ ID NO:255) and Protein Sequence (SEQ ID NO:256) of Ms1.2 tct gat ggc agg aat att gca gtc gac gac aga tgg tct ttc tat acg Ser Asp Gly Arg Asn Ile Ala Val Asp Asp Arg Trp Ser Phe Tyr Thr ctc ttc cat get act tgc tgt gcc gat cct gac tgt aga ttc cgg ccc Leu Phe His Ala Thr Cys Cys Ala Asp Pro Asp Cys Arg Phe Arg Pro ggt tgt tgatctttgt tcttcaaaga cgctgctggc ccaggaccct ctgaaccacg Gly Cys acgt DNA Sequence (SEQ ID NO:257) and Protein Sequence (SEQ ID NO:258) of Ms1.3 atc aag aat act gca gcc agc aac aaa gcg cct agc ctg gtg get att Ile Lys Asn Thr Ala Ala Ser Asn Lys Ala Pro Ser Leu Val Ala Ile gcc gtc agg gga tgc tgt tac aat cct tcc tgt tgg ccg aaa aca tat Ala Val Arg Gly Cys Cys Tyr Asn Pro Ser Cys Trp Pro Lys Thr Tyr tgt agt tggaaaggct gatgctccag gaccctctga accacgacgt Cys Ser DNA Sequence (SEQ ID NO:259) and Protein Sequence (SEQ ID NO:260) of Ms1.4 tct gat agc agg aat gtc gca atc gag gac aga gtg tct gac ctg cac Ser Asp Ser Arg Asn Val Ala Ile Glu Asp Arg Val Ser Asp Leu His tct atg ttc ttc gat gtt tct tgc tgt agc aat cct acc tgt aaa gaa Ser Met Phe Phe Asp Val Ser Cys Cys Ser Asn Pro Thr Cys Lys Glu acg tat ggt tgt tgatcgttgg ttttgaagac gctgatgctc caggaccctc Thr Tyr Gly Cys DNA Sequence (SEQ ID NO:261) and Protein Sequence (SEQ ID NO:262) of Ms1.5 tct gtt ggc agg aat att gca gtc gac gac aga ggg att ttc tct acg Ser Val Gly Arg Asn Ile Ala Val Asp Asp Arg Gly Ile Phe Ser Thr ctc ttc cat get cat tgc tgt gcc aat ccc atc tgt aaa aac acg ccc Leu Phe His Ala His Cys Cys Ala Asn Pro Ile Cys Lys Asn Thr Pro ggt tgt tgatctttgt tcttcaaaga cgctgctggc ccaggaccct ctgaaccacg Gly Cys acgt DNA Sequence (SEQ ID NO:263) and Protein Sequence (SEQ ID NO:264) of Ms1.8 tcc gat ggc agg aat gtc gca atc gac gac aga gtg tct gac ctg cac Ser Asp Gly Arg Asn Val Ala Ile Asp Asp Arg Val Ser Asp Leu His tct atg ttc ttc gat att get tgc tgt aac aat cct acc tgt aaa gaa Ser Met Phe Phe Asp Ile Ala Cys Cys Asn Asn Pro Thr Cys Lys Glu acg tat ggt tgt tgatcgttgg ttttgaagac gctgatgctc caggaccctc Thr Tyr Gly Cys tgaaccacga cgt DNA Sequence (SEQ ID NO:265) and Protein Sequence (SEQ ID NO:266) of Ms1.9 tct gat ggc agg aat gtc gca atc gag gac aga gtg tct gac ctg ctc Ser Asp Gly Arg Asn Val Ala Ile Glu Asp Arg Val Ser Asp Leu Leu tct atg ctc ttc gat gtt get tgc tgt agc aat cct gtc tgt aaa gaa Ser Met Leu Phe Asp Val Ala Cys Cys Ser Asn Pro Val Cys Lys Glu acg tat ggt tgt tgatcgttgg ttttgaagac gctgatgctc caggaccctc Thr Tyr Gly Cys tgaaccacga cgt DNA Sequence (SEQ ID NO:267) and Protein Sequence (SEQ ID NO:268) of Bt1.7 tat gat ggc agg aat get gcc gcc gac gac aaa get ttt gac ctg ctg Tyr Asp Gly Arg Asn Ala Ala Ala Asp Asp Lys Ala Phe Asp Leu Leu 5 get atg acc ata agg gga gga tgc tgt tcc tat cct ccc tgt atc gcg Ala Met Thr Ile Arg Gly Gly Cys Cys Ser Tyr Pro Pro Cys Ile Ala agt aat cct aaa tgt ggt gga aga cgc tgatgctcca ggaccctctg Ser Asn Pro Lys Cys Gly Gly Arg Arg aaccacaacg t DNA Sequence (SEQ ID NO:269) and Protein Sequence (SEQ ID NO:270) of Lv1.5 ttt gat ggc agg aat get gca ggc aac gcc aaa atg tcc gcc ctg atg Phe Asp Gly Arg Asn Ala Ala Gly Asn Ala Lys Met Ser Ala Leu Met gcc ctg acc atc agg gga tgc tgt tcc cat cct gtc tgt agc gcg atg 15 Ala Leu Thr Ile Arg Gly Cys Cys Ser His Pro Val Cys Ser Ala Met agt cca atc tgt ggc tgaagacgct gatgccccag gaccctctga accacgacgt Ser Pro Ile Cys Gly DNA Sequence (SEQ ID NO:271) and Protein Sequence (SEQ ID NO:272) of Ms1.10 20 atc aag aat get gca get gac gac aaa gca tct gac ctg ctc tct cag Ile Lys Asn Ala Ala Ala Asp Asp Lys Ala Ser Asp Leu Leu Ser Gln atc gtc agg aat get gca tcc aat gac aaa ggg tct gac ctg atg act Ile Val Arg Asn Ala Ala Ser Asn Asp Lys Gly Ser Asp Leu Met Thr ctt gcc ctc agg gga tgc tgt aaa aat cct tac t.gt ggt gcg tcg aaa 25 Leu Ala Leu Arg Gly Cys Cys Lys Asn Pro Tyr Cys Gly Ala Ser Lys aca tat tgt ggt aga aga cgc tgatgctcca ggaccctctg aaccacgacg t Thr Tyr Cys Gly Arg Arg Arg DNA Sequence (SEQ ID NO:273) and Protein Sequence (SEQ ID NO:274) of Oml.l 30 tctgatggca ggaatgccgc agcgtctgac ctgatggat ctg acc atc aag gga Leu Thr Ile Lys Gly tgc tgt tct tat cct ccc tgt ttc gcg act aat cca gac tgt ggt cga Cys Cys Ser Tyr Pro Pro Cys Phe Ala Thr Asn Pro Asp Cys Gly Arg cga cgc tgatgctcca ggaccctctg aaccacgacg t 35 Arg Arg DNA Sequence (SEQ ID NO:275) and Protein Sequence (SEQ ID NO:276) of R1.6 ttt gat ggc agg aat gcc gca gcc gac tac aaa ggg tct gaa ttg ctc Phe Asp Gly Arg Asn Ala Ala Ala Asp Tyr Lys Gly Ser Glu Leu Leu get atg acc gtc agg gga gga tgc tgt tcc tat cct ccc tgt atc gca Ala Met Thr Val Arg Gly Gly Cys Cys Ser Tyr Pro Pro Cys Ile Ala aat aat cct ctt tgt get gga aga cgc tga Asn Asn Pro Leu Cys Ala Gly Arg Arg DNA Sequence (SEQ ID NO:277) and Protein Sequence (SEQ ID NO:278) of R1.7 ttt gat ggc agg aat gcc gca gcc gac tac aaa ggg tct gaa ttg ctc Phe Asp Gly Arg Asn Ala Ala Ala Asp Tyr Lys Gly Ser Glu Leu Leu get atg acc gtc agg gga gga tgc tgt tcc tat cct ccc tgt atc gca Ala Met Thr Val Arg Gly Gly Cys Cys Ser Tyr Pro Pro Cys Ile Ala aat aat cct ttt tgt get gga aga cgc tga Asn Asn Pro Phe Cys Ala Gly Arg Arg DNA Sequence (SEQ ID NO:279) and Protein Sequence (SEQ ID NO:280) of Vrl.I
tct tat gac agg tat gcc tcg ccc gtc gac aga gcg tct gcc ctg atc Ser Tyr Asp Arg Tyr Ala Ser Pro Val Asp Arg Ala Ser Ala Leu Ile get cag gcc atc ctt cga gat tgc tgt tcc aat cct ccc tgt tcc caa Ala Gln Ala Ile'Leu Arg Asp Cys Cys Ser Asn Pro Pro Cys Ser Gln aat aat cca gac tgt atg taaagacgct gcttgctcca ggaccctctg Asn Asn Pro Asp Cys Met aaccacgacg t DNA Sequence (SEQ ID NO:281) and Protein Sequence (SEQ ID NO:282) of Vrl.2 tct tat ggc agg tat gcc tca ccc gtc gac aga gcg tct gcc ctg atc Ser Tyr Gly Arg Tyr Ala Ser Pro Val Asp Arg Ala Ser Ala Leu Ile get cag gcc atc ctt cga gat tgc tgc tcc aat cct cct tgt gcc cat Ala Gln Ala Ile Leu Arg Asp Cys Cys Ser Asn Pro Pro Cys Ala His aat aat cca gac tgt cgt taaagacgct gcttgctcca ggaccctctg Asn Asn Pro Asp Cys Arg aaccacgacg t DNA Sequence (SEQ ID NO:283) and Protein Sequence (SEQ ID NO:284) of A1.4 tct gat ggc agg aat gcc gca gcc aac gac aaa gcg tct ggc atg agc Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Gly Met Ser gcg ctg gcc gtc aat gaa tgc tgt acc aac cct gtc tgt cac gcg gaa Ala Leu Ala Val Asn Glu Cys Cys Thr Asn Pro Val Cys His Ala Glu cat caa gaa ctt tgt get aga aga cgc tga His Gln Glu Leu Cys Ala Arg Arg Arg DNA Sequence (SEQ ID NO:285) and Protein Sequence (SEQ ID NO:286) of A1.5 tct gat ggc agg aat gcc gca gcc aac gac aaa gcg tct gac gtg atc Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Val Ile acg ctg gcc ctc aag gga tgc tgt tcc aac cct gtc tgt cac ttg gag Thr Leu Ala Leu Lys Gly Cys Cys Ser Asn Pro Val Cys His Leu Glu cat tca aac ctt tgt ggt aga aga cgc tga His Ser Asn Leu Cys Gly Arg Arg Arg DNA Sequence (SEQ ID NO:287) and Protein Sequence (SEQ ID NO:288) of A1.6 tct gat ggc agg aat gcc gca gcc aac gac aaa gcg tct ggc atg agc Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Gly Met Ser gcg ctg gcc gtc aat gaa tgc tgt acc aac cct gtc tgt cac gtg gaa Ala Leu Ala Val Asn Glu Cys Cys Thr Asn Pro Val Cys His Val Glu cat caa gaa ctt tgt get aga aga cgc tga His Gln Glu Leu Cys Ala Arg Arg Arg DNA Sequence (SEQ ID NO:289) and Protein Sequence (SEQ ID NO:290) of Afl.l atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca ttt cgt ggc agg aat gcc gca gcc aaa gcg Phe Thr Ser Asp Arg Ala Phe Arg Gly Arg Asn Ala Ala Ala Lys Ala tct ggc ctg gtc ggt ctg acc gac aag agg caa gaa tgc tgt tct tat Ser Gly Leu Val Gly Leu Thr Asp Lys Arg Gln Glu Cys Cys Ser Tyr cct gcc tgt aac cta gat cat cca gaa ctt tgt ggt tgaagacgct Pro Ala Cys Asn Leu Asp His Pro Glu Leu Cys Gly gatgctccag gaccctctga accacgacgt DNA Sequence (SEQ ID NO:291) and Protein Sequence (SEQ ID NO:292) of Afl.2 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser tcc act tca ggt cgt cgt gca ttt cgt ggc agg aat gcc gca gcc aaa Ser Thr Ser Gly Arg Arg Ala Phe Arg Gly Arg Asn Ala Ala Ala Lys gcg tct gga ctg gtc ggt ctg act gac agg aga cca gaa tgc tgt agt Ala Ser Gly Leu Val Gly Leu Thr Asp Arg Arg Pro Glu Cys Cys Ser gat cct cgc tgt aac tcg act cat cca gaa ctt tgt ggt gga aga cgc Asp Pro Arg Cys Asn Ser Thr His Pro Glu Leu Cys Gly Gly Arg Arg tgatgctcca ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:293) and Protein Sequence (SEQ ID NO:294) of Arl.2 tct gat ggc agg aat gcc gca gcc aac gcg ttt gac ctg atc gat ctg Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Phe Asp Leu Ile Asp Leu acc gcc agg cta aat tgc tgt atg att ccc ccc tgt tgg aag aaa tat Thr Ala Arg Leu Asn Cys Cys Met Ile Pro Pro Cys Trp Lys Lys Tyr gga gac aga tgt agt gaa gta cgc tgatgctcca ggaccctctg aaccacgacg Gly Asp Arg Cys Ser Glu Val Arg t DNA Sequence (SEQ ID NO:295) and Protein Sequence (SEQ ID NO:296) of Arl.3 tct gat ggc agg aat gcc gca cgc aaa gcg ttt ggc tgc tgc gac tta Ser Asp Gly Arg Asn Ala Ala Arg Lys Ala Phe Gly Cys Cys Asp Leu ata ccc tgt ttg gag aga tat ggt aac aga tgt aat gaa gtg cac Ile Pro Cys Leu Glu Arg Tyr Gly Asn Arg Cys Asn Glu Val His tgatgctcca ggaccctctg aaccacgcga cgt DNA Sequence (SEQ ID NO:297) and Protein Sequence (SEQ ID NO:298) of Arl.4 tct gat ggc agc aat gcc gca gcc aac gag ttt gac ctg atc get ctg Ser Asp Gly Ser Asn Ala Ala Ala Asn Glu Phe Asp Leu Ile Ala Leu acc gcc agg cta ggt tgc tgt aac gtt aca ccc tgt tgg gag aaa tat Thr Ala Arg Leu Gly Cys Cys Asn Val Thr Pro Cys Trp Glu Lys Tyr gga gac aaa tgt aat gaa gta cgc tgatgcttca ggaccctctg aaccacgacg Gly Asp Lys Cys Asn Glu Val Arg t DNA Sequence (SEQ ID NO:299) and Protein Sequence (SEQ ID NO:300) of Arl.5 tct gat ggc agg aat gtc gca gca aaa gcg ttt cac cgg atc ggc cgg Ser Asp Gly Arg Asn Val Ala Ala Lys Ala Phe His Arg Ile Gly Arg acc atc agg gat gaa tgc tgt tcc aat cct gcc tgt agg gtg aat aat Thr Ile Arg Asp Glu Cys Cys Ser Asn Pro Ala Cys Arg Val Asn Asn cca cac gtt tgt aga cga cgc tgatgctcca ggaccctctg aaccacgacg t Pro His Val Cys Arg Arg Arg DNA Sequence (SEQ ID NO:301) and Protein Sequence (SEQ ID NO:302) of Arl.6 tct gat ggc agg aat gcc gca gcc aac gcg ttt gac ctg atg cct ctg Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Phe Asp Leu Met Pro Leu acc gcc agg cta aat tgc tgt agc att ccc ggc tgt tgg aac gaa tat Thr Ala Arg Leu Asn Cys Cys Ser Ile Pro Gly Cys Trp Asn Glu Tyr aaa gac aga tgt agt aaa gta cgc tgatgctcca ggaccctctg aaccacgacg Lys Asp Arg Cys Ser Lys Val Arg t DNA Sequence (SEQ ID NO:303) and Protein Sequence (SEQ ID NO:304) of Ayl.2 tctgatggca ggaatgccgc agccgacgac aaagcgtctg acctggtcgc t ctg gtc Leu Val gtc agg gga gga tgc tgt tcc cac cct gtc tgt tac ttt aat aat cca Val Arg Gly Gly Cys Cys Ser His Pro Val Cys Tyr Phe Asn Asn Pro caa atg tgt cgt gga aga cgc tgatgctcca ggaccctctg aaccacgacg t Gln Met Cys Arg Gly Arg Arg DNA Sequence (SEQ ID NO:305) and Protein Sequence (SEQ ID NO:306) of Ayl.3 tctgatggca ggaatgccgc agccgacgac aaagcgtctg acctggtcgc t ctg gcc Leu Ala gtc agg gga gga tgc tgt tcc cac cct gtc tgt aac ttg aat aat cca Val Arg Gly Gly Cys Cys Ser His Pro Val Cys Asn Leu Asn Asn Pro caa atg tgt cgt gga aga cgc tgatgctcca ggaccctctg aaccacgacg t Gln Met Cys Arg Gly Arg Arg DNA Sequence (SEQ ID NO:307) and Protein Sequence (SEQ ID NO:308) of Btl.8 ttt cgt ggc agg aat ccc gca gcc aac gac aaa agg tct gac ctg gcc Phe Arg Gly Arg Asn Pro Ala Ala Asn Asp Lys Arg Ser Asp Leu Ala get ctg agc gtc agg gga gga tgc tgt tcc cat cct gcc tgt agc gtg Ala Leu Ser Val Arg Gly Gly Cys Cys Ser His Pro Ala Cys Ser Val 5 act cat cca gag ctt tgt ggc tgaagacgct gatgccccag gaccctctga Thr His Pro Glu Leu Cys Gly accacgacgt DNA Sequence (SEQ ID NO:309) and Protein Sequence (SEQ ID NO:310) of Bt1.9 10 tct gat ggc ggg aat gcc gca gcc aaa gcg tct gac ctg atc get cag Ser Asp Gly Gly Asn Ala Ala Ala Lys Ala Ser Asp Leu Ile Ala Gln acc atc agg gga gga tgc tgt tcc tat cct gcc tgt agc gtg gaa cat Thr Ile Arg Gly Gly Cys Cys Ser Tyr Pro Ala Cys Ser Val Glu His caa gac ctt tgt gat gga aga cgc tgatgctcca ggaccctctg aaccacgacg 15 Gln Asp Leu Cys Asp Gly Arg Arg t DNA Sequence (SEQ ID NO:31 1) and Protein Sequence (SEQ ID NO:312) of Cal.3 tct tat ggc agg aat gcc gca gcc aaa gcg ttt gaa gtg agt tgc tgt 20 Ser Tyr Gly Arg Asn Ala Ala Ala Lys Ala Phe Glu Val Ser Cys Cys gtc gtt cgc ccc tgt tgg att cgc tat caa gag gaa tgt ctt gaa gca Val Val Arg Pro Cys Trp Ile Arg Tyr Gln Glu Glu Cys Leu Glu Ala gat ccc agg acc ctc tga Asp Pro Arg Thr Leu DNA Sequence (SEQ ID NO:313) and Protein Sequence (SEQ ID NO:314) of Cal.4 tct gat ggc agg aat gcc gca gcc aac gcc ctt gac ctg atc act ctg Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Leu Asp Leu Ile Thr Leu atc gcc agg caa aat tgc tgt agc att ccc ggc tgt tgg gag aaa tat 30 Ile Ala Arg Gln Asn Cys Cys Ser Ile Pro Gly Cys Trp Glu Lys Tyr gga gac aaa tgt agt gaa gta cgc tga Gly Asp Lys Cys Ser Glu Val Arg DNA Sequence (SEQ ID NO:315) and Protein Sequence (SEQ ID NO:316) of C1.2 35 tct gat ggc agg aat gaa gca gcc aac gac gaa gcg tct gac gtg atc Ser Asp Gly Arg Asn Glu Ala Ala Asn Asp Glu Ala Ser Asp Val Ile gag ctg gcc ctc aag gga tgc tgt tcc aac cct gtc tgt cac ttg gag Glu Leu Ala Leu Lys Gly Cys Cys Ser Asn Pro Val Cys His Leu Glu cat cca aac get tgt ggt aga aga cgc tgatgctcca ggaccctctg His Pro Asn Ala Cys Gly Arg Arg Arg aaccacgacg t DNA Sequence (SEQ ID NO:317) and Protein Sequence (SEQ ID NO:318) of C1.3 tct gat ggc agg aat gcc gca gcc aac gac aaa gcg tct gac ctg gtc Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Leu Val get ctg gcc gtc agg gga tgc tgt tcc aac cct atc tgt tac ttt aat Ala Leu Ala Val Arg Gly Cys Cys Ser Asn Pro Ile Cys Tyr Phe Asn aat cca cga att tgt cgt gga aga cgc tgatgctcca ggaccctctg Asn Pro Arg Ile Cys Arg Gly Arg Arg aaccacgacg t DNA Sequence (SEQ ID NO:319) and Protein Sequence (SEQ ID NO:320) of Epl.2 tct cat ggc agg aat gcc gca cgc aaa gcg tct gac ctg atc get ctg Ser His Gly Arg Asn Ala Ala Arg Lys Ala Ser Asp Leu Ile Ala Leu acc gtc agg gaa tgc tgt tct cag cct ccc tgt cgc tgg aaa cat cca Thr Val Arg Glu Cys Cys Ser Gln Pro Pro Cys Arg Trp Lys His Pro gaa ctt tgt agt tga Glu Leu Cys Ser DNA Sequence (SEQ ID NO:321) and Protein Sequence (SEQ ID NO:322) of G1.1 tct gat ggc agg aat gac gca gcc aaa gcg ttt gac ctg ata tct tcg Ser Asp Gly Arg Asn Asp Ala Ala Lys Ala Phe Asp Leu Ile Ser Ser acc gtc aag aaa gga tgc tgt tcc cat cct gcc tgt gcg ggg aat aat Thr Val Lys Lys Gly Cys Cys Ser His Pro Ala Cys Ala Gly Asn Asn caa cat att tgt ggc cga aga cgc tgatgctcca ggaccctctg aaccacgacg Gln His Ile Cys Gly Arg Arg Arg t DNA Sequence (SEQ ID NO:323) and Protein Sequence (SEQ ID NO:324) of G1.3 tct gat ggc agg aat gcc gca gcc aac gac caa gcg tct gac ctg atg Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Gln Ala Ser Asp Leu Met get gcg acc gtc agg gga tgc tgt gcc gtt cct tcc tgt cgc ctc cgt Ala Ala Thr Val Arg Gly Cys Cys Ala Val Pro Ser Cys Arg Leu Arg aat cca gac ctt tgt ggt gga gga cgc tgatgctcca ggaccctctg Asn Pro Asp Leu Cys Gly Gly Gly Arg aaccacgacg t DNA Sequence (SEQ ID NO:325) and Protein Sequence (SEQ ID NO:326) of Iml.3 ctt gat gaa agg aat gcc gca gcc gac gac aaa gcg tct gac ctg atc Leu Asp Glu Arg Asn Ala Ala Ala Asp Asp Lys Ala Ser Asp Leu Ile get caa atc gtc agg aga gga tgc tgt tcc cat cct gcc tgt aac gtg Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Ala Cys Asn Val aat aat cca cac att tgt ggt tga Asn Asn Pro His Ile Cys Gly DNA Sequence (SEQ ID NO:327) and Protein Sequence (SEQ ID NO:328) of Lv1.2 tct gat ggc agg aat act gca gcc aaa gtc aaa tat tct aag acg ccg Ser Asp Gly Arg Asn Thr Ala Ala Lys Val Lys Tyr Ser Lys Thr Pro gag gaa tgc tgt ccc aat cct ccc tgt ttc gcg aca aat tcg gat att Glu Glu Cys Cys Pro Asn Pro Pro Cys Phe Ala Thr Asn Ser Asp Ile tgt ggc gga aga cgc tgatgctcca ggaccctctg aaccacgacg t Cys Gly Gly Arg Arg DNA Sequence (SEQ ID NO:329) and Protein Sequence (SEQ ID NO:330) of Lvl.3 tct aat ggc agg aat gcc gca gcc aaa ttc aaa gcg cct gcc ctg atg Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met aag cgg acc gtc agg gat get tgc tgt tca gac cct cgc tgt tcc ggg Lys Arg Thr Val Arg Asp Ala Cys Cys Ser Asp Pro Arg Cys Ser Gly aaa cat caa gac ctg tgt ggc tgaagacgct gatgctccag gaccctctga Lys His Gln Asp Leu Cys Gly accacgacgt DNA Sequence (SEQ ID NO:331) and Protein Sequence (SEQ ID NO:332) of Lv1.4 tct aat ggc agg aat gcc gca gcc aaa ttc aaa gcg cct gcc ctg atg Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met gag ctg acc gtc agg gaa gat tgc tgt tca gac cct cgc tgt tcc gtg Glu Leu Thr Val Arg Glu Asp Cys Cys Ser Asp Pro Arg Cys Ser Val gga cat caa gac ctg tgt ggc tgaagacgct gatgctccag gaccctctga Gly His Gln Asp Leu Cys Gly accacgacgt DNA Sequence (SEQ ID NO:333) and Protein Sequence (SEQ ID NO:334) of Lv1.6 gca ttt gat ggc agg aat get gca gcc agc gac aaa gcg tcc gag ctg Ala Phe Asp Gly Arg Asn Ala Ala Ala Ser Asp Lys Ala Ser Glu Leu atg get ctg gcc gtc agg gga tgc tgt tcc cat cct gcc tgt get ggg Met Ala Leu Ala Val Arg Gly Cys Cys Ser His Pro Ala Cys Ala Gly agt aat gca cat atc tgt ggc aga aga cgc tgatgctcca ggaccctctg Ser Asn Ala His Ile Cys Gly Arg Arg Arg aaccacgacg t DNA Sequence (SEQ ID NO:335) and Protein Sequence (SEQ ID NO:336) of Lvl.7 tct aat ggc agg aat gcc gca gcc aaa ttc aaa gcg cct gcc ctg atg Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met aag ctg acc gtc agg gag gat tgc tgt tca gac cct cgc tgt tcc gtg Lys Leu Thr Val Arg Glu Asp Cys Cys Ser Asp Pro Arg Cys Ser Val gga cat caa gac atg tgt ggc tgaagacgct gatgctccag gaccctctga Gly His Gln Asp Met Cys Gly atcacgacgt DNA Sequence (SEQ ID NO:337) and Protein Sequence (SEQ ID NO:338) of Lv1.8 ttt gaa tgc agg aat get gca ggc aac gac aaa gcg act gac ctg atg Phe Glu Cys Arg Asn Ala Ala Gly Asn Asp Lys Ala Thr Asp Leu Met get ctg act gtc agg gga tgc tgt tcc cat cct gcc tgt get ggg aat Ala Leu Thr Val Arg Gly Cys Cys Ser His Pro Ala Cys Ala Gly Asn aat cca cat atc tgc ggc tgaagacgct gatgctccag gaccctctga Asn Pro His Ile Cys Gly accacgacgt DNA Sequence (SEQ ID NO:339) and Protein Sequence (SEQ ID NO:340) of Lv1.9 ttt gat ggc agg aac gcc gca gcc aac aac aaa gcg act gat ctg atg Phe Asp Gly Arg Asn Ala Ala Ala Asn Asn Lys Ala Thr Asp Leu Met get ctg act gtc aga gga tgc tgt ggc aat cct tca tgt agc atc cat Ala Leu Thr Val Arg Gly Cys Cys Gly Asn Pro Ser Cys Ser Ile His att cct tac gtt tgt aat tagagacact gatgctccag gaccctctga Ile Pro Tyr Val Cys Asn accacgacgt DNA Sequence (SEQ ID NO:341) and Protein Sequence (SEQ ID NO:342) of Lv1.10 tct aat ggc agg aat gcc gca gcc aaa ttc aaa gcg cct gcc ctg atg Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met aag cgg acc gac agc gaa gaa tgc tgt tta gac tct cgc tgt gcc ggg Lys Arg Thr Asp Ser Glu Glu Cys Cys Leu Asp Ser Arg Cys Ala Gly caa cat caa gac ctg tgt ggc gga aga cgc tgatgctcca ggaccctctg Gin His Gln Asp Leu Cys Gly Gly Arg Arg aaccacgacg t DNA Sequence (SEQ ID NO:343) and Protein Sequence (SEQ ID NO:344) of Mr1.3 tct gat ggc agg aat gcc gca gcc aag gac aaa gcg tct gac ctg gtc Ser Asp Gly Arg Asn Ala Ala Ala Lys Asp Lys Ala Ser Asp Leu Val get ctg acc gtc aag gga tgc tgt tct aat cct ccc tgt tac gcg aat Ala Leu Thr Val Lys Gly Cys Cys Ser Asn Pro Pro Cys Tyr Ala Asn aat caa gcc tat tgt aat gga aga cgc tga Asn Gln Ala Tyr Cys Asn Gly Arg Arg DNA Sequence (SEQ ID NO:345) and Protein Sequence (SEQ ID NO:346) of Mrl.4 tct gat ggc agg aat gcc gca gcc aag gac aaa gcg tct gac ctg gtc Ser Asp Gly Arg Asn Ala Ala Ala Lys Asp Lys Ala Ser Asp Leu Val get ctg acc gtc aag gga tgc tgt tct cat cct gcc tgt agc gtg aat Ala Leu Thr Val Lys Gly Cys Cys Ser His Pro Ala Cys Ser Val Asn aat cca gac att tgt ggt tga Asn Pro Asp Ile Cys Gly DNA Sequence (SEQ ID NO:347) and Protein Sequence (SEQ ID NO:348) of Ms1.1 tct gat ggc agg aat get gca gcc aac aac aaa gtg get ttg acc atg Ser Asp Gly Arg Asn Ala Ala Ala Asn Asn Lys Val Ala Leu Thr Met agg gga aaa tgc tgt atc aat gat gcg tgt cgc tcg aaa cat cca cag Arg Gly Lys Cys Cys Ile Asn Asp Ala Cys Arg Ser Lys His Pro Gln tac tgt tct gga aga cgc tgatactcca ggaccctctg aaccacgacg t Tyr Cys Ser Gly Arg Arg DNA Sequence (SEQ ID NO:349) and Protein Sequence (SEQ ID NO:350) of Ms1.6 tct gat ggc agg aat get gca gcc aac gac aaa gtg tct gac cag atg Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Val Ser Asp Gln Met 5 get ctg gtt gtc agg gga tgc tgt tac aat att gcc tgt aga att aat Ala Leu Val Val Arg Gly Cys Cys Tyr Asn Ile Ala Cys Arg Ile Asn aat cca cgg tac tgt cgt gga aaa cgc tgatgttcca ggaccctctg Asn Pro Arg Tyr Cys Arg Gly Lys Arg aaccacgacg t DNA Sequence (SEQ ID NO:351) and Protein Sequence (SEQ ID NO:352) of 01.1 tctgaaggca ggaatgccgc agccaacgac aaagcgtctg acctgatggc t ctg aac Leu Asn gtc agg gga tgc tgt tcc cat cct gtc tgt cgc ttc aat tat cca aaa 15 Val Arg Gly Cys Cys Ser His Pro Val Cys Arg Phe Asn Tyr Pro Lys tat tgt ggt gga aga cgc tgatggtcca ggaccctctg aaccacgacg t Tyr Cys Gly Gly Arg Arg DNA Sequence (SEQ ID NO:353) and Protein Sequence (SEQ ID NO:354) of 01.2 20 tctgatggcg ggaatgccgc agcaaaagcg tttgatctaa tcact ctg gcc ctc agg Leu Ala Leu Arg gat gaa tgc tgt gcc agt cct ccc tgt cgt ttg aat aat cca tac gta Asp Glu Cys Cys Ala Ser Pro Pro Cys Arg Leu Asn Asn Pro Tyr Val tgt cat tgacgacgct gatgctccag gaccctctga accacgacgt 25 Cys His DNA Sequence (SEQ ID NO:355) and Protein Sequence (SEQ ID NO:356) of 01.4 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser 30 ccc act tca gat cgt gca tct gat agg agg aat gcc gca gcc aaa gcg Pro Thr Ser Asp Arg Ala Ser Asp Arg Arg Asn Ala Ala Ala Lys Ala ttt gac ctg aga tat tcg acc gcc aag aga gga tgc tgt tcc aat cct Phe Asp Leu Arg Tyr Ser Thr Ala Lys Arg Gly Cys Cys Ser Asn Pro gtc tgt tgg cag aat aat gca gaa tac tgt cgt gaa agt ggc 35 Val Cys Trp Gln Asn Asn Ala Glu Tyr Cys Arg Glu Ser Gly taatgctcca ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:357) and Protein Sequence (SEQ ID NO:358) of 01.7 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca tct gat ggc ggg aat gtc gca gcg tct cac Phe Thr Ser Asp Arg Ala Ser Asp Gly Gly Asn Val Ala Ala Ser His ctg atc get ctg acc atc aag gga tgc tgt tct cac cct ccc tgt gcc Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser His Pro Pro Cys Ala cag aat aat caa gac tat tgt ggt tgacgacgct gatgctccag gaccctctga Gln Asn Asn Gln Asp Tyr Cys Gly accacgacgt DNA Sequence (SEQ ID NO:359) and Protein Sequence (SEQ ID NO:360) of 01.8 atg ttc acc gtg ttt ctg ttg gtt gtc tta tca acc acc gtc gtt tcc Met Phe Thr Val Phe Leu Leu Val Val Leu Ser Thr Thr Val Val Ser tcc act tca gat cgt gca tct gat agg agg aat gcc gca gcc aaa gcg Ser Thr Ser Asp Arg Ala Ser Asp Arg Arg Asn Ala Ala Ala Lys Ala tct gac ctg atg tat tcg acc gtc aag aaa gga tgt tgt tcc cat cct Ser Asp Leu Met Tyr Ser Thr Val Lys Lys Gly Cys Cys Ser His Pro gcc tgt tcg ggg aat aat cga gaa tat tgt cgt gaa agt ggc Ala Cys Ser Gly Asn Asn Arg Glu Tyr Cys Arg Glu Ser Gly taatgctcca ggaccctctg aaccacgacg t DNA Sequence (SEQ ID NO:361) and Protein Sequence (SEQ ID NO:362) of Om1.2 tttgatggca ggaatgcctc agccgacagc aaagtggctg cccggatcgc t cag atc Gln Ile gac agg gat cca tgc tgt tcc tat cct gac tgt ggc gcg aat cat cca Asp Arg Asp Pro Cys Cys Ser Tyr Pro Asp Cys Gly Ala Asn His Pro gag att tgt ggt gga aaa cgc tgatgctcca ggaccctctg aaccacgacg t Glu Ile Cys Gly Gly Lys Arg DNA Sequence (SEQ ID NO:363) and Protein Sequence (SEQ ID NO:364) of Om1.3 tctcatggca ggaatgccgc acgct ctg acc gtc agg gaa tgc tgt tct cag Leu Thr Val Arg Glu Cys Cys Ser Gln cct cct tgt cgc tgg aaa cat cca gaa ctt tgt agt tgaagacgct Pro Pro Cys Arg Trp Lys His Pro Glu Leu Cys Ser gatgctccag gaccctctga accacgacgt DNA Sequence (SEQ ID NO:365) and Protein Sequence (SEQ ID NO:366) of Oml.4 tttgatggca ggaatgctgc agccagcgac aaagcgtctg agctgatggc t ctg gcc Leu Ala gtc agg gga tgc tgt tcc cat cct gcc tgt get ggg aat aat cca cat Val Arg Gly Cys Cys Ser His Pro Ala Cys Ala Gly Asn Asn Pro His atc tgt ggc aga aga cgc tgatgctcca ggaccctctg aaccacgacg t Ile Cys Gly Arg Arg Arg DNA Sequence (SEQ ID NO:367) and Protein Sequence (SEQ ID NO:368) of Oml.5 tctggtgtca ggaaagacgc agcgcctggc ctgatcgct ctg acc atc aag gga Leu Thr Ile Lys Gly tgc tgt tct gat cct agc tgt aac gtg aat aat cca gac tat tgt ggt Cys Cys Ser Asp Pro Ser Cys Asn Val Asn Asn Pro Asp Tyr Cys Gly tgacgacgct gatgctccag gaccctctga accacgacgt DNA Sequence (SEQ ID NO:369) and Protein Sequence (SEQ ID NO:370) of Om1.6 tctaatggca ggaatgccgc agccaaattc aaagcgcctg ccctgatgga g ctg acc 57 Leu Thr gtc agg gaa gaa tgc tgt tca gac cct cgc tgt tcc gtg gga cat caa 105 Val Arg Glu Glu Cys Cys Ser Asp Pro Arg Cys Ser Val Gly His Gln gat atg tgt cgg tgaagcacgt gatgctccag gaccctctga accacgacgt 157 Asp Met Cys Arg DNA Sequence (SEQ ID NO:371) and Protein Sequence (SEQ ID NO:372) of P1.4 act gat ggc agg aat get gca gcc ata gcg ctt gac ctg atc get ccg Thr Asp Gly Arg Asn Ala Ala Ala Ile Ala Leu Asp Leu Ile Ala Pro gcc gtc agg gga gga tgc tgt tcc aat cct gcc tgt tta gtg aat cat Ala Val Arg Gly Gly Cys Cys Ser Asn Pro Ala Cys Leu Val Asn His cta gaa atg tgt ggt aaa aga cgc tgatgcccca ggaccctctg aaccacgacg Leu Glu Met Cys Gly Lys Arg Arg t DNA Sequence (SEQ ID NO:373) and Protein Sequence (SEQ ID NO:374) of P1.5 tct gat ggc agg gat gcc gca gcc aac gac aaa gcg tct gac ctg atc Ser Asp Gly Arg Asp Ala Ala Ala Asn Asp Lys Ala Ser Asp Leu Ile get ctg acc gcc agg aga gat cca tgc tgt ttc aat cct gcc tgt aac Ala Leu Thr Ala Arg Arg Asp Pro Cys Cys Phe Asn Pro Ala Cys Asn gtg aat aat cca cag att tgt ggt tgaagacgct gatgctccag gaccctctga Val Asn Asn Pro Gln Ile Cys Gly accacgacgt DNA Sequence (SEQ ID NO:375) and Protein Sequence (SEQ ID NO:376) of P1.6 tct gat ggc agg gat get gag aaa aca ggc ttt gac acg acc att gtg Ser Asp Gly Arg Asp Ala Glu Lys Thr Gly Phe Asp Thr Thr Ile Val ccg gaa gac tgc tgt tcg gat cct tcc tgt tgg agg ctg cat agt tta Pro Glu Asp Cys Cys Ser Asp Pro Ser Cys Trp Arg Leu His Ser Leu get tgt act gga att gta aac cgc tgatgctcca ggaccctctg aaccacgacg Ala Cys Thr Gly Ile Val Asn Arg t DNA Sequence (SEQ ID NO:377) and Protein Sequence (SEQ ID NO:378) of P1.8 act gat ggc agg agt get gca gcc ata gcg ttt gcc ctg atc get ccg Thr Asp Gly Arg Ser Ala Ala Ala Ile Ala Phe Ala Leu Ile Ala Pro acc gtc tgc tgt act aat cct gcc tgt ctc gtg aat aat ata cgc ttt Thr Val Cys Cys Thr Asn Pro Ala Cys Leu Val Asn Asn Ile Arg Phe tgt ggt gga aga cgc tgatgcccca ggaccctctg aaccacgacg t Cys Gly Gly Arg Arg DNA Sequence (SEQ ID NO:379) and Protein Sequence (SEQ ID NO:380) of Rgl.1 tct gat gga aga aat gcc gca agc gac gcc aaa gcg ttt ccc cgg atc Ser Asp Gly Arg Asn Ala Ala Ser Asp Ala Lys Ala Phe Pro Arg Ile get cca atc gtc agg gac gaa tgc tgt agc gat cct agg tgt cac ggg Ala Pro Ile Val Arg Asp Glu Cys Cys Ser Asp Pro Arg Cys His Gly aat aat cgg gac cac tgt get tgaagacgct gctgctccag gaccctctga Asn Asn Arg Asp His Cys Ala accacgacgt DNA Sequence (SEQ ID NO:381) and Protein Sequence (SEQ ID NO:382) of Rg1.3 tct gat ggc agg aat acc gcg gcc gac gaa aaa gcg tcc gac ctg atc Ser Asp Gly Arg Asn Thr Ala Ala Asp Glu Lys Ala Ser Asp Leu Ile tct caa act gtc aag aga gat tgc tgt tcc cat cct ctc tgt aga tta Ser Gln Thr Val Lys Arg Asp Cys Cys Ser His Pro Leu Cys Arg Leu ttt gtt cca gga ctt tgt att tgaagacgct gctgctccag gaccctctga Phe Val Pro Gly Leu Cys Ile accacgact DNA Sequence (SEQ ID NO:383) and Protein Sequence (SEQ ID NO:384) of Rg1.4 tct gat ggc agg aat gcc gca gcc gac aac aaa gcg tct gac cta atc Ser Asp Gly Arg Asn Ala Ala Ala Asp Asn Lys Ala Ser Asp Leu Ile get caa atc gtc agg aga gga tgc tgt tcc cat cct gtc tgt aaa gtg Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Val Cys Lys Val agg tat cca gac ctg tgt cgt tgaagacgct gctgctccag gaccctctga Arg Tyr Pro Asp Leu Cys Arg accacgacgt DNA Sequence (SEQ ID NO:385) and Protein Sequence (SEQ ID NO:386) of Rg1.5 tct gat ggc agg aat gcc gca gcc gac aac aga gcg tct gac cta atc Ser Asp Gly Arg Asn Ala Ala Ala Asp Asn Arg Ala Ser Asp Leu Ile get caa atc gtc agg aga gga tgc tgt tcc cat cct gcc tgt aat gtg Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Ala Cys Asn Val aat aat cca cac att tgt ggt tgaagacgct gctgctccag gaccctctga Asn Asn Pro His Ile Cys Gly accacgacgt DNA Sequence (SEQ ID NO:387) and Protein Sequence (SEQ ID NO:-3 )88) of Rg1.8 tct gat ggc agg aat gcc gca gcc gac aac aaa ccg tct gac cta atc Ser Asp Gly Arg Asn Ala Ala Ala Asp Asn Lys Pro Ser Asp Leu Ile get caa atc gtc agg aga gga tgc tgt tcg cat cct gtc tgt aaa gtg Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Val Cys Lys Val agg tat tca gac atg tgt ggt tgaagacgct gctgctccag gaccctctga Arg Tyr Ser Asp Met Cys Gly accacgacgt DNA Sequence (SEQ ID NO:389) and Protein Sequence (SEQ ID NO:390) of Sml.4 tct gat ggc agg aat gca gag cga cga caa agc gtc tgt cct ggt cgc Ser Asp Gly Arg Asn Ala Glu Arg Arg Gin Ser Val Cys Pro Gly Arg 5 tct ggc ccc agg gga gga tgt tgt tcc cac cct gcc tgt aag gtg cat Ser Gly Pro Arg Gly Gly Cys Cys Ser His Pro Ala Cys Lys Val His ttt cca cac agt tgt ggt tgacgacgct gatgctccag gaccctctga Phe Pro His Ser Cys Giy accacgacgt DNA Sequence (SEQ ID NO:391) and Protein Sequence (SEQ ID NO:392) of Sml.5 tct gat ggc agg aat gcc gca gcc agc gac aga gcg tct gac gcg gcc Ser Asp Gly Arg Asn Ala Ala Ala Ser Asp Arg Ala Ser Asp Ala Ala cac cag gta tgc tgt tcc aac cct gtc tgt cac gtg gat cat cca gaa 15 His Gln Val Cys Cys Ser Asn Pro Val Cys His Val Asp His Pro Glu ctt tgt cgt aga aga cgc tgatgctcca ggaccctctg aaccacgacg t Leu Cys Arg Arg Arg Arg DNA Sequence (SEQ ID NO:393) and Protein Sequence (SEQ ID NO:394) of S1.5 20 tct gat ggc agg aat gcc gcg gcc aac gac aaa gcg tct gac ctg gtc Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Leu Val get ccg gcc atc agg gga tgc tgt tcc cac cct gtc tgt aac ttg agt Ala Pro Ala Ile Arg Gly Cys Cys Ser His Pro Val Cys Asn Leu Her aat cca caa att tgt cgt gga aga cgc tgatgctcca ggaccctctg 25 Asn Pro Gin Ile Cys Arg Gly Arg Arg aaccacgacg t DNA Sequence (SEQ ID NO:395) and Protein Sequence (SEQ ID NO:396) of Tx1.5 ttt cat ggc agg aat gcc gca gcc aaa gcg tct ggc ctg gtc ggt ctg 30 Phe His Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Gly Leu acc gac aag agg caa gaa tgc tgt tct cat cct gcc tgt aac gta gat Thr Asp Lys Arg Gln Glu Cys Cys Ser His Pro Ala Cys Asn Val Asp cat cca gaa att tgt cgt tga His Pro Glu Ile Cys Arg DNA Sequence (SEQ ID NO:397) and Protein Sequence (SEQ ID NO:398) of T1.1 act gat ggc agg agt get gca gcc ata gcg ttt gcc ctg atc get ccg Thr Asp Gly Arg Ser Ala Ala Ala Ile Ala Phe Ala Leu Ile Ala Pro acc gtc tgg gaa gga tgc tgt tct aat cct gcc tgt ctc gtg aat cat Thr Val Trp Glu Gly Cys Cys Ser Asn Pro Ala Cys Leu Val Asn His ata cgc ttt tgt ggt gga aga cgc tgatgcccca ggaccctctg aaccacgacg Ile Arg Phe Cys Gly Gly Arg Arg t DNA Sequence (SEQ ID NO:399) and Protein Sequence (SEQ ID NO:400) of Vr1.3 tct aat ggc atg aat gcc gca gcc atc agg aaa gcg tct gcc ctg gtg Ser Asn Gly Met Asn Ala Ala Ala Ile Arg Lys Ala Ser Ala Leu Val get cag atc gcc cat cga gac tgc tgt gac gat cct gcc tgc acc gtg Ala Gln Ile Ala His Arg Asp Cys Cys Asp Asp Pro Ala Cys Thr Val aat aat cca ggc ctt tgc act tgaagatgct gctgccccag gaccctctga Asn Asn Pro Gly Leu Cys Thr accacgacgt DNA Sequence (SEQ ID NO:401) and Protein Sequence (SEQ ID NO:402) of G1.2 tct gat ggc ggg aat gcc gca gca aaa gag tct gac gtg atc get ctg Ser Asp Gly Gly Asn Ala Ala Ala Lys Glu Ser Asp Val Ile Ala Leu acc gtc tgg aaa tgc tgt acc att cct tcc tgt tat gag aaa aaa aaa Thr Val Trp Lys Cys Cys Thr Ile Pro Ser Cys Tyr Glu Lys Lys Lys att aaa gca tgt gtc ttt tgacgacgct gatgctccag gaccctctga Ile Lys Ala Cys Val Phe accacgacgt DNA Sequence (SEQ ID NO:403) and Protein Sequence (SEQ ID NO:404) of Rgl .12 tct gat ggc gca gtc gac gac aaa gcg ttg gat cga atc get gaa atc Ser Asp Gly Ala Val Asp Asp Lys Ala Leu Asp Arg Ile Ala Glu Ile gtc agg aga gga tgc tgt ggc aat cct gcc tgt agc ggc tcc tcg aaa Val Arg Arg Gly Cys Cys Gly Asn Pro Ala Cys Ser Gly Ser Ser Lys gat gca ccc tct tgt ggt tgaagacgct gctgctccag gaccctctga Asp Ala Pro Ser Cys Gly accacgacgt It will be appreciated that the methods and compositions of the instant invention can be incorporated in the form of a variety of embodiments, only a few of which are disclosed herein. It will be apparent to the artisan that other embodiments exist and do not depart from the spirit of the invention. Thus, the described embodiments are illustrative and should not be construed as restrictive.

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1.

SEQUENCE LISTING
<110> Cognetix, Inc.
University Of Utah Research Foundation <120> Alpha-Conotoxin Peptides <130> 08-892290CA
<140> 2,361,534 <141> 2000-01-28 <150> US 60/118,381 <151> 1999-01-29 <160> 404 <170> Patentln Ver. 2.0 <210> 1 <211> 17 <212> PRT
<213> Artificial Sequence <220>
<223> Description of Artificial Sequence:Alpha-Conotoxin Peptide Generic Formula I

<220>
<221> PEPTIDE
<222> (1) .. (3) <223> Xaa at residue 1 is des-Xaa, Ile, Leu or Val; Xaa at residue 2 is des-Xaa, Ala or Gly; Xaa at residue 3 is des-Xaa, Gly, Trp (D or L), neo-Trp, halo-Trp or any unnatural aromatic amino acid.
<220>
<221> PEPTIDE
<222> (4) <223> N-methyl-Lys, Xaa at residue 4 is des-Xaa, Gly, Trp (D or L), neo--Trp, halo-Trp or any unnatural aromatic amino acid.
<220>
<221> PEPTIDE
<222> (5) <223> Xaa at residue 5 is Glu, gamma-carboxy-Glu (Gla), Asp, Ala, Thr, Ser, Gly, Ile, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid.

<220>
<221> PEPTIDE
<222> (8) <223> Xaa at residue 8 is Ser, Thr, Arg, ornithine, homoarginine, Lys,, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.
<220>
<221> PEPTIDE
<222> (9) <223> Xaa at residue 9 is Asp, Glu, Gla, Arg, ornithine, homoarginine, Lys, N-methyl-Lys,N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.

<220>
<221> PEPTIDE
<222> (10) <223> Xaa at residue 10 is Ser, Thr, Asn, Ala, Gly, His, halo-His, Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (11) <223> Xaa at residue 11 is Thr, Ser, Ala, Asp, Asn, Pro, hydroxy-Pro, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.
<220>
<221> PEPTIDE
<222> (13) <223> Xaa at residue 13 is Gly, Ser, Thr, Ala, Asn, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.
<220>
<221> PEPTIDE
<222> (14) <223> Xaa at residue 14 is Gln, Leu, His, halo-His, Trp (D or L), halo-Trp, neo-Trp, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr, Arg, ornithine.
<220>
<221> PEPTIDE
<222> (14) <223> Xaa at residue 14 is also homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid or any unnatural aromatic amino acid-<220>
<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is Asn, His, halo-His, Ile, Leu, Val, Gln, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.
<220>
<221> PEPTIDE
<222> (17) <223> Xaa at residue 17 is des-Xaa, Val, Ile, Leu, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.

<400> 1 Xaa Xaa Xaa Xaa Xaa Cys Cys Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Cys Xaa <210> 2 <211> 21 <212> PRT
<213> Artificial Sequence <220>
<223> Description of Artificial Sequence:Alpha-Conotoxin Peptide Generic Formula II.

<220>
<221> PEPTIDE
<222> (1)..(3) <223> Xaa at residue 1 is des-Xaa, Asp, Glu or gamma-carboxy-Glu (Gla); Xaa at residue 2 is des-Xaa, Gln, Ala, Asp, Glu, Gla; Xaa at residue 3 is des-Xaa, Gly, Ala, Asp, Glu, Gla, Pro or hydroxy-Pro.
<220>
<221> PEPTIDE
<222> (4) <223> Xaa at residue 4 is des-Xaa, Gly, Glu, Gla, Gln, Asp, Asn, Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (7) <223> Xaa at residue 7 is Ser, Thr, Gly, Glu, Gla, Asn, Trp (D or L), neo-Trp, halo-Trp, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid.
<220>
<221> PEPTIDE
<222> (7) <223> Xaa at residue 7 is also Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid.

<220>
<221> PEPTIDE
<222> (8) <223> Xaa at residue 8 is Asp, Asn, His, halo-His, Thr, Ser, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid.

<220>
<221> PEPTIDE
<222> (9) <223> Xaa at residue 9 is Pro or hydroxy-Pro.
<220>
<221> PEPTIDE
<222> (10) <223> Xaa at residue 10 is Ala, Ser, Thr, Asp, Val, Ile, Pro, hydroxy-Pro, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpha-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid.

<220>
<221> PEPTIDE
<222> (12) <223> Xaa at residue 12 is Gly, Ile, Leu, Val, Ala, Thr, Ser, Pro, hydroxy-Pro, Phe, Trp (D or L), neo-Trp, halo-Trp, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys.

<220>
<221> PEPTIDE
<222> (12)..(13) <223> Xaa at residue 12 is also N,N,N-trimethyl-Lys, any unnatural basic amino acid or any unnatural aromatic amino acid; Xaa at residue 13 is Ala, Asn, Phe, Pro, hydroxy-Pro, Glu, Gla, Gln, His, halo-His, Val, Ser.
<220>
<221> PEPTIDE
<222> (13) <223> Xaa at residue 13 is also Thr, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.
<220>
<221> PEPTIDE
<222> (14) <223> Xaa at residue 14 is Thr, Ser, His, halo-His, Leu, Ile, Val, Asn, Met:, Pro, hydroxy-Pro, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid.
<220>
<221> PEPTIDE
<222> (14) .. (15) <223> Xaa at residue 14 is also Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa at residue 15 is Asn, Pro, hydroxy-Pro, Gln, Ser, Thr.
<220>
<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is also Thr, Arg, ornithine, homoarginine, Lys, N-=methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr.
<220>
<221> PEPTIDE
<222> (15)..(16) <223> Xaa at residue 15 is also 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa at residue 16 is des-Xaa, Gly, Thr, Ser, Pro, hydroxy-Pro, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr.

<220>
<221> PEPTIDE
<222> (16) <223> Xaa at residue 16 is also O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid.

<220>
<221> PEPTIDE
<222> (17) <223> Xaa at residue 17 is des-Xaa, Ile, Val, Asp, Leu, Phe, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr.
<220>
<221> PEPTIDE
<222> (17) .. (19) <223> Xaa at residue 17 is also O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa at residue 19 is des-Xaa, Gly, Ala, Met, Ser, Thr, Trp (D or L), neo-Trp, halo-Trp.

<220>
<221> PEPTIDE
<222> (19) <223> Xaa at residue 19 is also any unnatural aromatic amino acid, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-d:i.methyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.

<220>
<221> PEPTIDE
<222> (20) <223> Xaa at residue 20 is des-Xaa, Trp (D or L), neo-Trp, halo-Trp, any unnatural aromatic amino acid, Arg, ornithine, homoargirine, Lys, N-methyl-Lys.

<220>
<221> PEPTIDE
<222> (20) <223> Xaa at residue 20 is also N,N-di-methyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.
<220>
<221> PEPTIDE
<222> (21) <223> Xaa at residue 21 is des-Xaa, Arg, ornithine, homoarginine, Lys, N--methyl--Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.

<400> 2 Xaa Xaa Xaa Xaa Cys Cys Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa <210> 3 <211> 28 <212> PRT
<213> Artificial Sequence <220>
<223> Description of Artificial Sequence.Alpha-Conotoxin Peptide Generic Formula III.

<220>
<221> PEPTIDE
<222> (1)..(3) <223> Xaa at residue 1 is des-Xaa, Ser or Thr; Xaa at residue 2 is des-Xaa, Asp, Glu, gamma-carboxy-Glu (Gla), Asn, Ser or Thr; Xaa at residue 3 is des-Xaa, Ala, Gly, Asn, Ser, Thr, Pro, hydroxy-Pro.
<220>
<221> PEPTIDE
<222> (3) <223> Xaa at residue 3 is also Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.

<220>
<221> PEPTIDE
<222> (4) ... (5) <223> Xaa at residue 4 is des-Xaa, Ala, Val, Leu, Ile, Gly, Glu, Gla, Gln, Asp, Asn, Phe, Pro, hydroxy-Pro or any unnatural aromatic amino acid Xaa at residue 5 is des-Xaa, Thr, Ser, Asp, Glu, Gla, Gin, Gly, Val, Asp.
<220>
<221> PEPTIDE
<222> (5) <223> Xaa at residue 5 is also Asn, Ala, Pro, hydroxy-Pro, Arg, ornithine, homo-arginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.

<220>
<221> PEPTIDE
<222> (8) <223> Xaa at residue 8 is Thr, Ser, Asp, Asn, Met, Val, Ala, Gly, Leu, Ile, Phe, any unnatural aromatic amino acid, Pro, hydroxy-Pro, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr.

<220>
<221> PEPTIDE
<222> (8) .. (9) <223> Xaa at residue 8 is also nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa at residue 9 is Ile, Leu, Val, Ser, Thr, Gln, Asn, Asp, Arg, His, halo-His, Phe.
<220>
<221> PEPTIDE
<222> (9) <223> Xaa at residue 9 is also any unnatural aromatic amino acid, homoarginine, ornithine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N--trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Tyr, mono-halo-Tyr.

<220>
<221> PEPTIDE
<222> (9) .. (10) <223> Xaa at residue 9 is also di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa at residue 10 is Pro, hyroxy-Pro, Ser, Thr, Ile, Asp, Leu, Val, Gly, Ala.
<220>
<221> PEPTIDE
<222> (10) <223> Xaa at residue 10 is also Phe, any unnatural aromatic amino acid, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-.Lys, N,N,N-tri-methyl-Lys or any unnatural basic amino acid.
<220>
<221> PEPTIDE
<222> (11) <223> Xaa at residue 11 is Val, Ala, Gly, Ile, Leu, Asp, Ser, Thr, Pro, hydroxy-Pro, Arg,. ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys.
<220>
<221> PEPTIDE
<222> (11)..(13) <223> Xaa at residue 11 is also N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa at residue 13 is His, halo-His, Arg, homoarginine, ornithine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys.

<220>
<221> PEPTIDE
<222> (13) <223> Xaa at residue 13 is also any unnatural basic amino acid, Asn, Ala,Ser, Thr, Phe, Ile, Leu, Gly, Trp (D or L), neo-Trp, halo-Trp, any unnatural aromatic amino acid, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr.
<220>
<221> PEPTIDE
<222> (13)..(14) <223> Xaa at residue 13 is also 0-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa at residue 14 is Leu, Gln, Val, Ile, Gly, Met, Ala, Lys, N-methyl-Lys, N,N-dimethyl-Lys.

<220>
<221> PEPTIDE
<222> (14) <223> Xaa at residue 14 is also N,N,N-tri-methyl-Lys, Ser, Thr, Arg, homoarginine, ornithine, any unnatural basic amino acid, Asn, Glu, Gla, Gln, Phe, Trp (D or L).
<220>
<221> PEPTIDE
<222> (14)..(15) <223> Xaa at residue 14 is also neo-Trp, halo-Trp or any unnatural aromatic amino acid; Xaa at residue 15 is Glu, Gla, Gln, Asn, Asp, Pro, hydroxy-Pro, Ser, Gly, Thr, Lys, N-methyl-Lys, N,N-dimethyl-Lys.
<220>
<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is also N,N,N-trimethyl-Lys, Arg, homoarginine, ornithine, any unnatural basic amino acid, Phe, His, halo-His, any unnatural aromatic acid, Leu, Met, Gly, Ala, Tyr, nor-Tyr, mono-halo-Tyr.
<220>
<221> PEPTIDE
<222> (15)..(16) <223> Xaa at residue 15 is also di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa at residue 16 is His, 'l halo-His, Asn, Thr, Ser, Ile, Val, Leu, Phe.
<220>
<221> PEPTIDE
<222> (16) <223> Xaa at residue 16 is also any unnatural aromatic amino acid, Arg, homoarginine, ornithine, Lys, N-methyl-Lys, N,N-di.methyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid, Tyr, nor-Try.

<220>
<221> PEPTIDE
<222> (16)..(17) <223> Xaa at residue 16 is also mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid; Xaa at residue 17 is Ser, Thr, Ala, Gln, Pro, hydroxy-Pro.
<220>
<221> PEPTIDE
<222> (17) <223> Xaa at residue 17 is also Gly, Ile, Leu, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.

<220>
<221> PEPTIDE
<222> (18) <223> Xaa at residue 18 is Asn, Glu, Gla, Asp, Gly, His, halo-His, Ala, Leu, Gln, Arg, ornithine, homo-arginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys, any unnatural basic amino acid.

<220>
<221> PEPTIDE
<222> (18) <223> Xaa at residue 18 is also Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr or any unnatural hydroxy containing amino acid.

<220>
<221> PEPTIDE
<222> (19) <223> Xaa at residue 19 is Met, Ile, Thr, Ser, Val, Leu, Pro, hydroxy-Pro, Phe, any unnatural aromatic amino acid, Tyr, nor-Tyr, mono- halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr, nitro-Tyr.

<220>
<221> PEPTIDE
<222> (19) <223> Xaa at residue 19 is also any unnatural hydroxy containing amino acid, Glu, Gla, Ala, His, halo-His, Arg, ornithine, homoarginine, Lys, N-methyl-Lys.
<220>
<221> PEPTIDE
<222> (19)..(21) <223> Xaa at residue 19 is also N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa at residue 21 is des-Xaa, Gly, Asp, Asn, Ala, Ile, Leu, Ser, Thr, His, halo-His, Arg, ornithine.

<220>
<221> PEPTIDE
<222> (21)..(22) <223> Xaa at residue 21 is also homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa at residue 22 is des-Xaa, Gly, Glu, Gla, Gln, Trp (D or L), neo-Trp.
<220>
<221> PEPTIDE
<222> (22) <223> Xaa at residue 22 is also halo-Trp, any unnatural aromatic amino acid, Arg,ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.

<220>
<221> PEPTIDE
<222> (23) <223> Xaa at residue 23 is des-Xaa, Ser, Thr, Val, Ile, Ala, Arg, ornithine, homo-arginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.

<220>
<221> PEPTIDE
<222> (24) <223> Xaa at residue 24 is des-Xaa, Val, Asp, His, halo-His, Arg, ornithine, homoarginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any unnatural basic amino acid.
<220>
<221> PEPTIDE
<222> (25)..(26) <223> Xaa at residue 25 is des-Xaa, Asn, Pro or hydroxy-Pro;
Xaa at residue 26 is des-Xaa, Arg, ornithine, homo-arginine, Lys, N-methyl-Lys, N,N-dimethyl-Lys.

<220>
<221> PEPTIDE
<222> (26)..(28) <223> Xaa at residue 26 is also N,N,N-trimethyl-Lys or any unnatural basic amino acid; Xaa at residue 27 is des-Xaa, Ser or Thar; Xaa at residue 28 is des-Xaa, Leu, Ile or Val.

<400> 3 Xaa Xaa Xaa Xaa Xaa Cys Cys Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa <210> 4 <211> 14 <212> PRT
<213> Conus imperialis <220>
<221> PEPTIDE
<222> (2)..(11) <223> Xaa at residue 2 is Glu or gamma-carboxy-Glu; Xaa at residue 11 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.

<400> 4 Asp Xaa Cys Cys Ser Asp Ser Arg Cys Gly Xaa Asn Cys Leu <210> 5 <211> 12 <212> PRT
<213> Conus imperialis <220>
<221> PEPTIDE
<222> (10) <223> Xaa at residue 10 is Trp (D or L) or halo-Trp.
<400> 5 Ala Cys Cys Ser Asp Arg Arg Cys Arg Xaa Arg Cys <210> 6 <211> 13 <212> PRT
<213> Conus regius <400> 6 Phe Thr Cys Cys Arg Arg Gly Thr Cys Ser Gin His Cys <210> 7 <211> 13 <212> PRT
<213> Conus regius 1.2 <220>
<221> PEPTIDE
<222> (2) <223> Xaa at residue 2 :is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<400> 7 Asp Xaa Cys Cys Arg Arg His Ala Cys Thr Leu Ile Cys <210> 8 <211> 13 <212> PRT
<213> Conus regius <220>
<221> PEPTIDE
<222> (2)..(8) <223> Xaa at residue 2 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr; Xaa at residues 7 and 8 is Pro or hydroxy-Pro.

<400> 8 Asp Xaa Cys Cys Arg Arg Xaa Xaa Cys Thr Leu Ile Cys <210> 9 <211> 13 <212> PRT
<213> Conus regius <220>
<221> PEPTIDE
<222> (6)..(10) <223> Xaa at residue 6 is Pro or hdroxy-Pro; Xaa at residue 10 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 9 Gly Cys Cys Ser Asp Xaa Arg Cys Arg Xaa Arg Cys Arg <210> 10 <211> 13 <212> PRT
<213> Conus regius <220>
<221> PEPTIDE

1.3 <222> (7) (11) <223> Xaa at residue 7 is Pro or hydroxy-Pro; Xaa at residue 11 is Trp (D or L) or halo-Trp.

<400> 10 Gly Gly Cys Cys Ser Asp Xaa Arg Cys Ala Xaa Arg Cys <210> 11 <211> 17 <212> PRT
<213> Conus regius <220>
<221> PEPTIDE
<222> (3)..(10) <223> Xaa at residue 3 is Trp (D or L) or halo-Trp; Xaa at residue 9 is Glu or gamma-carboxy-Glu; Xaa at residue 10 is Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl--Lys.
<400> 11 Ile Ala Xaa Asp Ile Cys Cys Ser Xaa Xaa Asp Cys Asn His Xaa Cys Val <210> 12 <211> 12 <212> PRT
<213> Conus regius <220>
<221> PEPTIDE
<222> (6)..(9) <223> Xaa at residue 6 is Pro or hydroxy-Pro; Xaa at residue 9 is Lys, N-methyl-Lys, N,N-dimethyl.-Lys or N,N,N-trimethyl.-Lys.

<400> 12 Gly Cys Cys Ser Asp Xaa Arg Cys Xaa His Gln Cys <210> 13 <211> 14 <212> PRT

<213> Conus sponsalis <220>
<221> PEPTIDE
<222> (5)..(11) <223> Xaa at residues 5 and 11 is Pro or hydroxy-Pro;
Xaa at residue 8 is Lys, N-methyl-Lys, N.N-dimethyl-Lys or N.N.n-trimethyl-Lys.

<400> 13 Cys Cys Ser Asp Xaa Ala Cys Xaa Gln Thr Xaa Gly Cys Arg <210> 14 <211> 13 <212> PRT
<213> Conus sponsalis <220>
<221> PEPTIDE
<222> (3) .. (5) <223> Xaa at residue 3 is Glu or gamma-carboxy-Glu; Xaa at residue 5 is Pro or hydroxy--Pro.

<400> 14 Cys Cys Xaa Asn Xaa Ala Cys Arg His Thr Gln Gly Cys <210> 15 <211> 13 <212> PRT
<213> Conus sulcatus <220>
<221> PEPTIDE
<222> (4)..(12) <223> Xaa at residue 4 is Trp or halo-Trp; Xaa at residue 6 is Pro or hydroxy-Pro; Xaa at residue 12 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 15 Gly Cys Cys Xaa His Xaa Ala Cys Gly Arg His Xaa Cys <210> 16 <211> 14 <212> PRT
<213> Conus achatinus <220>
<221> PEPTIDE

<222> (2) .. (11) <223> Xaa at residues 2 and 7 is Pro or hydroxy-Pro; Xaa at residue 11 is Lys, N--methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.

<400> 16 Ala Xaa Cys Cys Asn Asn Xaa Ala Cys Val Xaa His Arg Cys <210> 17 <211> 15 <212> PRT
<213> Conus bullatus <220>
<221> PEPTIDE
<222> (2)..(12) <223> Xaa at residues 2 and 8 is Pro or hydroxy-Pro; Xaa at residue 12 is Lys, N-methyl--Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.

<400> 17 Ala Xaa Gly Cys Cys Asn Asn Xaa Ala Cys Val Xaa His Arg Cys <210> 18 <211> 14 <212> PRT
<213> Conus bullatus <220>
<221> PEPTIDE
<222> (1)..(11) <223> Xaa at residues 1, 2 and 7 is Pro or hydroxy-Pro;
Xaa at residue 11 is Lys, N--methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.

<400> 18 Xaa Xaa Cys Cys Asn Asn Xaa Ala Cys Val Xaa His Arg Cys <210> 19 <211> 16 <212> PRT
<213> Conus bullatus <220>
<221> PEPTIDE
<222> (2)..(13) <223> Xaa at residue 2 is Glu or gamma-carboxy-Glu; Xaa at residue 6 is Trp or halo-Trp; Xaa at residues 8 11 and 13 is Pro or hydroxy-Pro.

<400> 19 Asp Xaa Asn Cys Cys Xaa Asn Xaa Ser Cys Xaa Arg Xaa Arg Cys Thr <210> 20 <211> 13 <212> PRT
<213> Conus bullatus <220>
<221> PEPTIDE
<222> (6) .. (12) <223> Xaa at residues 6 and 7 is Pro or hydroxy-Pro; Xaa at residue 12 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<400> 20 Gly Cys Cys Ser Arg Xaa Xaa Cys Ala Val Leu Xaa Cys <210> 21 <211> 13 <212> PRT
<213> Conus circumcisus <220>
<221> PEPTIDE
<222> (6) <223> Xaa at residue 6 is Pro or hydroxy-Pro.
<400> 21 Gly Cys Cys Gly Asn Xaa Asp Cys Thr Sear His Ser Cys <210> 22 <211> 16 <212> PRT
<213> Conus stercusmuscarum <220>
<221> PEPTIDE
<222> (6)..(11) <223> Xaa at residue 6 is Pro or hydroxy-Pro; Xaa at residue 11 is Glu or gamma-carboxy-Glu.

<400> 22 Gly Cys Cys Ser Asn Xaa Val. Cys His Leu Xaa His Ser Asn Met Cys <210> 23 <211> 17 <212> PRT
<213> Conus obscurus <220>
<221> PEPTIDE
<222> (6)..(15) <223> Xaa at residue 6 is Pro or hydroxy-Pro; Xaa at residue 14 is Glu or gamma-carboxy-Glu; Xaa at residue 15 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or <220>
<221> PEPTIDE
<222> (15) <223> nitro-Tyr.
<400> 23 Gly Cys Cys Ser Asn Xaa Val Cys Arg Gln Asn Asn Ala Xaa Xaa Cys Arg <210> 24 <211> 18 <212> PRT
<213> Conus textile <220>
<221> PEPTIDE
<222> (1) .. (15) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-Pro;
Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 24 Xaa Gln Cys Cys Ser His Xaa Ala Cys Asn Val Asp His Xaa Xaa Ile Cys Arg <210> 25 <211> 18 <212> PRT
<213> Conus radiatus <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-Pro;
Xaa at residues 2 and 15 is Glu or gamma-carboxy-Glu.

<400> 25 Xaa Xaa Cys Cys Ser His Xaa Ala Cys Asn Val Asp His Xaa Xaa Ile Cys Arg <210> 26 <211> 18 <212> PRT
<213> Conus radiatus <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-Pro;
Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 26 Xaa Gln Cys Cys Ser His Xaa Ala Cys Asn Val Asp His Xaa Xaa Ile Cys Asp <210> 27 <211> 18 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (1) .. (15) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-Pro;
Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 27 Xaa Arg Cys Cys Ser His Xaa Ala Cys Asn Val Asp His Xaa Xaa Ile Cys Arg <210> 28 <211> 18 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (1) .. (14) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-Pro.

<400> 28 Xaa Gln Cys Cys Ser His Xaa Ala Cys Asn Val Asp His Xaa Gly Ile Cys Arg <210> 29 <211> 18 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-Pro;
Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 29 Xaa Gln Cys Cys Ser His Xaa Ala Cys Asn Val Asp His Xaa Xaa Thr Cys Arg <210> 30 <211> 18 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-Pro;
Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 30 Xaa Gln Cys Cys Ser His Xaa Ala Cys Asn Val Asp His Xaa Xaa Val Cys Arg <210> 31 <211> 18 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-Pro;

Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 31 Xaa Gln Cys Cys Ser His Xaa Ala Cys Asn Ile Asp His Xaa Xaa Ile Cys Arg <210> 32 <211> 21 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-Pro;
Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 32 Xaa Gln Cys Cys Ser His Xaa Ala Cys Asn Val Asp His Xaa Xaa Ile Cys Arg Arg Arg Arg <210> 33 <211> 17 <212> PRT
<213> Conus betulinus <220>
<221> PEPTIDE
<222> (7)..(15) <223> Xaa at residues 7 and 14 is Pro or hydroxy-Pro;
Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 33 Gly Gly Cys Cys Ser His Xaa Ala Cys Ala Val Asn His Xaa Xaa Leu Cys <210> 34 <211> 16 <212> PRT
<213> Conus betulinus <220>
<221> PEPTIDE
<222> (6)..(14) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residue 14 is Glu or gamma-carboxy-Glu.
<400> 34 Gly Cys Cys Ser His Xaa Ala Cys Ser Val Asn His Xaa Xaa Leu Cys <210> 35 <211> 16 <212> PRT
<213> Conus dalli <220>
<221> PEPTIDE
<222> (6) .. (14) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residue 14 is Glu or gamma-carboxy-Gl.u.
<400> 35 Gly Cys Cys Ser His Xaa Ala Cys Asn Val Asp His Xaa Xaa Ile Cys <210> 36 <211> 19 <212> PRT
<213> Conus obscurus <220>
<221> PEPTIDE
<222> (6)..(18) <223> Xaa at residues 6 and 15 is Pro or hydroxy-Pro;
Xaa at reside 11 is Lys, N,-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys; Xaa at residues 14 and 18 is Glu or gamma-carboxy-Glu.
<400> 36 Gly Cys Cys Ser His Xaa Ala Cys Ser Gly Xaa Thr Gln Xaa Xaa Cys Arg Xaa Ser <210> 37 <211> 18 <212> PRT
<213> Conus tulipa <220>
<221> PEPTIDE
<222> (1)..(14) <223> Xaa at residues 1, 6 and 13 is Pro or hydroxy-Pro;
Xaa at residue 14 is Glu or gamma-carboxy-Glu.

<400> 37 Xaa Cys Cys Ser His Xaa Ala Cys Ser Gly Asn Asn Xaa Xaa Phe Cys Arg Gln <210> 38 <211> 18 <212> PRT
<213> Conus tulipa <220>
<221> PEPTIDE
<222> (6)..(14) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residue 14 is Glu or gamma-carboxy-Glu.
<400> 38 Gly Cys Cys Ser His Xaa Ala Cys Ser Gly Asn Asn Xaa Xaa Phe Cys Arg Gln <210> 39 <211> 16 <212> PRT
<213> Conus pennaceus <220>
<221> PEPTIDE
<222> (6)..(15) <223> Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro;
Xaa at residue 15 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 39 Gly Cys Cys Ser His Xaa Xaa Cys Ala Met Asn Asn Xaa Asp Xaa Cys <210> 40 <211> 16 <212> PRT
<213> Conus pennaceus <220>
<221> PEPTIDE
<222> (6)..(15) <223> Xaa at residuew 6, 7 and 13 is Pro or hydroxy-Pro;
Xaa at residue 15 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 40 Gly Cys Cys Ser His Xaa Xaa Cys Phe Leu Asn Asn Xaa Asp Xaa Cys <210> 41 <211> 17 <212> PRT
<213> Conus textile <220>
<221> PEPTIDE
<222> (6) .. (13) <223> Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro;
Xaa at residue 11 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N.N.N-trimethyl-Lys.

<400> 41 Gly Cys Cys Ser Asn Xaa Xaa Cys Ile Ala Xaa Asn Xaa His Met Cys Gly <210> 42 <211> 16 <212> PRT
<213> Conus distans <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro.
<400> 42 Gly Cys Cys Ser Asn Xaa Xaa Cys Ala His Asn Asn Xaa Asp Cys Arg <210> 43 <211> 17 <212> PRT
<213> Conus tulipa <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 43 Gly Cys Cys Ser Asn Xaa Ala Cys Ala Gly Asn Asn Xaa His Val Cys Arg <210> 44 <211> 16 <212> PRT
<213> Conus dalli <220>
<221> PEPTIDE
<222> (6) .. (13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 44 Gly Cys Cys Ser Arg Xaa Ala Cys Ile Ala Asn Asn Xaa Asp Leu Cys <210> 45 <211> 20 <212> PRT
<213> Conus circumcisus <220>
<221> PEPTIDE
<222> (6)..(14) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residues 11 and 14 is Glu or gamma-carboxy-Glu.

<400> 45 Gly Cys Cys Ser Asn Xaa Val Cys His Val Xaa His Xaa Xaa Leu Cys Arg Arg Arg Arg <210> 46 <211> 18 <212> PRT
<213> Conus sulcatus <220>
<221> PEPTIDE
<222> (7)..(14) <223> Xaa at residues 7, 17.2 and 14 is Pro or hydroxy-Pro; Xaa at residue 11 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.
<220>

<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 46 Gly Gly Cys Cys Ser Phe Xaa Ala Cys Arg Xaa Xaa Arg Xaa Xaa Met Cys Gly <210> 47 <211> 18 <212> PRT
<213> Conus textile <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-Pro;
Xaa at residues 2 and 15 is Glu or gamma-carboxy-Glu..
<400> 47 Xaa Xaa Cys Cys Ser Asp Xaa Arg Cys Asn Ser Ser His Xaa Xaa Leu Cys Arg <210> 48 <211> 18 <212> PRT
<213> Conus dalli <220>
<221> PEPTIDE
<222> (1) .. (15) <223> Xaa at residues 1, 7 and 14 is Pro or hydroxy-pro;
Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 48 Xaa Gln Cys Cys Ser Asp Xaa Arg Cys Asn Val Gly His Xaa Xaa Leu Cys Gly <210> 49 <211> 18 <212> PRT
<213> Conus dalli <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residue 1 Is Gln or pyro-Glu; Xaa at residues 7 and 14 is Pro or hydroxy--Pro; Xaa at residue 15 is Glu or gamma-carboxy-Glu.

<400> 49 Xaa Val Cys Cys Ser Asp Xaa Arg Cys Asn Val Gly His Xaa Xaa Ile Cys Gly <210> 50 <211> 16 <212> PRT
<213> Conus textile <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro.
<400> 50 Gly Cys Cys Ser Arg Xaa Xaa Cys Ile Ala Asn Asn Xaa Asp Leu Cys <210> 51 <211> 18 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residues 1 and 14 is Pro or hydroxy-Pro;
Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 51 Xaa Gln Cys Cys Ser His Leu Ala Cys Asn Val Asp His Xaa Xaa Ile Cys Arg <210> 52 <211> 19 <212> PRT
<213> Conus sulcatus <220>
<221> PEPTIDE

<222> (5)..(13) <223> Xaa at residue 5 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sul.pho-Tyr, O-phospho-Tyr or nitro-Tyr; Xaa at residue 13 is Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (14)..(18) <223> Xaa at residue 14 is Glu or gamma-carboxy-Glu; Xaa at residue 18 is Trp or halo-Trp.

<400> 52 Gly Cys Cys Ser Xaa Phe Asp Cys Arg Met Met Phe Xaa Xaa Met Cys Gly Xaa Arg <210> 53 <211> 18 <212> PRT
<213> Conus sulcatus <220>
<221> PEPTIDE
<222> (11)..(12) <223> Xaa at residue 11 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys; Xaa at residue 12 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<220>
<221> PEPTIDE
<222> (14)..(15) <223> Xaa at residue 14 is Pro or hydroxy-Pro; Xaa at residue 15 is Glu or gamma-carboxy-Glu.

<400> 53 Gly Gly Cys Cys Ser Phe Ala Ala Cys Arg Xaa Xaa Arg Xaa Xaa Met Cys Gly <210> 54 <211> 20 <212> PRT
<213> Conus sulcatus <220>
<221> PEPTIDE

<222> (7) (10) <223> Xaa at residue 7 is Pro or hydroxy-Pro; Xaa at residue 10 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<220>
<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 54 Gly Gly Cys Cys Phe His Xaa Val Cys Xaa Ile Asn Leu Leu Xaa Met Cys Arg Gln Arg <210> 55 <211> 19 <212> PRT
<213> Conus betulinus <220>
<221> PEPTIDE
<222> (7)..(15) <223> Xaa at residues 7, 11. and 1.4 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr; Xaa at residues 8, 9 and 15 is Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (12)..(16) <223> Xaa at residues 12 and 16 is Glu or gamma-carboxy-Glu.
<400> 55 Ser Ala Thr Cys Cys Asn Xaa Xaa Xaa Cys Xaa Xaa Thr Xaa Xaa Xaa Ser Cys Leu <210> 56 <211> 17 <212> PRT
<213> Conus betulinus <220>
<221> PEPTIDE
<222> (5)..(13) <223> Xaa at residues 5 and 12 is Tyr, no-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr; Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (10)..(14) <223> Xaa at residues 10 and 14 is Glu or gamma-carboxy-Glu.
<400> 56 Ala Cys Cys Ala Xaa Xaa Xaa Cys Phe Xaa Ala Xaa Xaa Xaa Arg Cys Leu <210> 57 <211> 19 <212> PRT
<213> Conus betulinus <220>
<221> PEPTIDE
<222> (3)..(16) <223> Xaa at residues 3, 12 and 16 is Glu or gamma-carboxy-Glu; Xaa at residues 6, 7, 11 and 14 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<220>
<221> PEPTIDE
<222> (8)..(15) <223> Xaa at residues 8, 9 and 15 is Pro or hydroxy-Pro.
<400> 57 Asn Ala Xaa Cys Cys Xaa Xaa Xaa Xaa Cys Xaa Xaa Ala Xaa Xaa Xaa Ile Cys Leu <210> 58 <211> 227 <212> DNA
<213> Conus magus <220>
<221> CDS
<222> (1)..(189) <400> 58 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Levu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat cgt gca tct gat ggc agg aat gcc gca gcc aac gac 96 Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp aaa gcg tct gac gtg atc acg ctg gcc ctc aag gga tgc tgt tcc aac 144 Lys Ala Ser Asp Val Ile Thr Leu Ala Leu Lys Gly Cys Cys Ser Asn cct gtc tgt cac ttg gag cat tca aac ctt tgt ggt aga aga cgc 189 Pro Val Cys His Leu Glu His Ser Asn Leu Cys Gly Arg Arg Arg tgatgctcca ggaccctctg aaccacgacg ttcgagca 227 <210> 59 <211> 63 <212> PRT
<213> Conus magus <400> 59 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Val Ile Thr Leu Ala Leu Lys Gly Cys Cys Ser Asn Pro Val Cys His Leu Glu His Ser Asn Le.u Cys Gly Arg Arg Arg <210> 60 <211> 208 <212> DNA
<213> Conus aulicus <220>
<221> CDS
<222> (1)..(168) <400> 60 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca tct gat ggc agg aag gac gca gcg tct ggc 96 Phe Thr Ser Asp Arg Ala Ser Asp Gly Arg Lys Asp Ala Ala Ser Gly ctg atc get ctg acc atc aag gga tgc tgt tct tat cct ccc tgt ttc 144 Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser Tyr Pro Pro Cys Phe gcg act aat tca gac tat tgt ggt tgacgacgct gatgctccag gaccctctga 198 Ala Thr Asn Ser Asp Tyr Cys Gly accacgacgt 208 <210> 61 <211> 56 <212> PRT
<213> Conus aulicus <400> 61 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Arg Ala Ser Asp Gly Arg Lys Asp Ala Ala Ser Gly Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser Tyr Pro Pro Cys Phe Ala Thr Asn Ser Asp Tyr Cys Gly <210> 62 <211> 205 <212> DNA
<213> Conus aulicus <220>
<221> CDS
<222> (1)..(174) <400> 62 atg ttc acc gtg ttt ctg ttg gtc gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca tct gat ggc agg aag gac gca gcg tct ggc 96 Phe Thr Ser Asp Arg Ala Ser Asp Gly Arg Lys Asp Ala Ala Ser Gly ctg att get ctg acc atg aag gga tgc tgt tct tat cct ccc tgt ttc 144 Leu Ile Ala Leu Thr Met Lys Gly Cys Cys Ser Tyr Pro Pro Cys Phe gcg act aat cca gac tgt ggt cga cga cgc tgatgctcca ggaccctctg 194 Ala Thr Asn Pro Asp Cys Gly Arg Arg Arg aaccacgacg t 205 <210> 63 <211> 58 <212> PRT
<213> Conus aulicus <400> 63 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Arg Ala Ser Asp Gly Arg Lys Asp Ala Ala Ser Gly Leu Ile Ala Leu Thr Met Lys Gly Cys Cys Ser Tyr Pro Pro Cys Phe Ala Thr Asn Pro Asp Cys Gly Arg Arg Arg <210> 64 <211> 223 <212> DNA
<213> Conus textile <220>
<221> CDS
<222> (1)..(192) <400> 64 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc tct tca ggt cgt agt aca ttt cgt ggc agg aat gcc gca gcc aaa 96 Phe Ser Ser Gly Arg Ser Thr Phe Arg Gly Arg Asn Ala Ala Ala Lys gcg tct ggc ctg gtc agt ctg act gac agg aga cca gaa tgc tgt agt 144 Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Glu Cys Cys Ser gat cct cgc tgt aac tcg agt cat cca gaa ctt tgt ggt gga aga cgc 192 Asp Pro Arg Cys Asn Ser Ser His Pro Glu Leu Cys Gly Gly Arg Arg tgatgctcca ggaccctctg aaccacgacg t 223 <210> 65 <211> 64 <212> PRT
<213> Conus textile <400> 65 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Ser Ser Gly Arg Ser Thr Phe Arg Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Glu Cys Cys Ser Asp Pro Arg Cys Asn Ser Ser His Pro Glu Leu Cys Gly Gly Arg Arg <210> 66 <211> 244 <212> DNA
<213> Conus textile <220>
<221> CDS
<222> (1)..(168) <400> 66 atg ttc acc gtg ttt ctg tt:g gtt gtc ttg gca acc gcc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Ala Val Val Ser ttc act tca gat cgt gca tct gat gac ggg aaa gcc get gcg tct gac 96 Phe Thr Ser Asp Arg Ala Ser Asp Asp Gly Lys Ala Ala Ala Ser Asp ctg atc act ctg acc atc aag gga tgc tgt tct cgt cct ccc tgt atc 144 Leu Ile Thr Leu Thr Ile Lys Gly Cys Cys Ser Arg Pro Pro Cys Ile gcg aat aat cca gac ttg tgt ggt tgacgacgct gatgctccag aacggtctga 198 Ala Asn Asn Pro Asp Leu Cys Gly accacgacgt tcgagcaatg ttcaccgtgt ttctgttggt tgtctt. 244 <210> 67 <211> 56 <212> PRT
<213> Conus textile <400> 67 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Ala Val Val Ser Phe Thr Ser Asp Arg Ala Ser Asp Asp Gly Lys Ala Ala Ala Ser Asp Leu Ile Thr Leu Thr Ile Lys Gly Cys Cys Ser Arg Pro Pro Cys Ile Ala Asn Asn Pro Asp Leu Cys Gly <210> 68 <211> 223 <212> DNA
<213> Conus textile <220>
<221> CDS
<222> (1)..(183) <400> 68 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt agt aca ttt cgt ggc agg aat gcc gca gcc aaa 96 Phe Thr Ser Gly Arg Ser Thr Phe Arg Gly Arg Asn Ala Ala Ala Lys gcg tct ggc ctg gtc agt ctg act gac agg aga cca caa tgc tgt tct 144 Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Gln Cys Cys Ser cat cct gcc tgt aac gta gat cat cca gaa att tgt cgt tgaagacgct 193 His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Arg gatgctccag gaccctctga accacgacgt 223 <210> 69 <211> 61 <212> PRT
<213> Conus textile <400> 69 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Gly Arg Ser Thr Phe Arg Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Gln Cys Cys Ser His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Arg <210> 70 <211> 223 <212> DNA
<213> Conus radiatus <220>
<221> CDS
<222> (1)..(183) <400> 70 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt cgt aca ttt cat ggc agg aat gcc gca gcc aaa 96 Phe Thr Ser Gly Arg Arg Thr Phe His Gly A2:.-g' Asn Ala Ala Ala Lys gcg tct ggc ctg gtc agt ctg act gac agg aga cca gaa tgc tgt tct 144 Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Glu Cys Cys Ser cat cct gcc tgt aac gta gat cat cca gaa att tgt cgt tgaagacgct 193 His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Arg gatgctccag gaccctctga accacgacgt 223 <210> 71 <211> 61 <212> PRT
<213> Conus radiatus <400> 71 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Gly Arg Arg Thr Phe His Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Glu Cys Cys Ser His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Arg <210> 72 <211> 223 <212> DNA
<213> Conus radiatus <220>
<221> CDS
<222> (1)..(183) <400> 72 atg ttc acc gtg ttt ctg tt:g gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt agt aca ttt cgt ggc agg aat gcc gca gcc aaa 96 Phe Thr Ser Gly Arg Ser Thr Phe Arg Gly Arg Asn Ala Ala Ala Lys gcg tct ggc ctg gtc agt ct:g act gac agg aga cca caa tgc tgt tct 144 Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Gln Cys Cys Ser cat cct gcc tgt aac gta gat cat cca gaa att tgc gat tgaagacgct 193 His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Asp gatgctccag gaccctctga accacgacgt 223 <210> 73 <211> 61 <212> PRT
<213> Conus radiatus <400> 73 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Gly Arg Ser Thr Phe Arg Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Ser Leu Thr Asp Arg Arg Pro Gln Cys Cys Ser His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Asp <210> 74 <211> 218 <212> DNA
<213> Conus striatus <220>
<221> CDS
<222> (1)..(171) <400> 74 atg ttc act gtg ttt ctg ttg gtt gtc ttg gca atc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Ile Thr Val Val Ser ttc cct tta gat cgt gaa tct gat ggc gcg aat gcc gaa gcc cgc acc 96 Phe Pro Leu Asp Arg Glu Ser Asp Gly Ala Asn Ala Glu Ala Arg Thr cac gat cat gag aag cac gca ctg gac cgg aat gga tgc tgt agg aat 144 His Asp His Glu Lys His Ala Leu Asp Arg Asn Gly Cys Cys Arg Asn cct gcc tgt gag agc cac aga tgt ggt tgacgacgct gatgctccag 191 Pro Ala Cys Glu Ser His A:rg Cys Gly gaccctctga accacgacgt tcgagca 218 <210> 75 <211> 57 <212> PRT
<213> Conus striatus <400> 75 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Ile Thr Val Val Ser Phe Pro Leu Asp Arg Glu Ser Asp Gly Ala Asn Ala Glu Ala Arg Thr His Asp His Glu Lys His Ala Leu Asp Arg Asn Gly Cys Cys Arg Asn Pro Ala Cys Glu Ser His Arg Cys Gly <210> 76 <211> 227 <212> DNA
<213> Conus bandanus <220>
<221> CDS
<222> (1)..(180) <400> 76 atg ttc acc atg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Met Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc get tca gat cgt gca tct gat ggc agg aat. gcc gca gcc aag gac 96 Phe Ala Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Lys Asp aaa gcg tct gac ctg gtc get ctg acc gtc aag gga tgc tgt tct cat 144 Lys Ala Ser Asp Leu Val Ala Leu Thr Val Lys Gly Cys Cys Ser His cct gcc tgt agc gtg aat aat cca gac att tgt ggt tgaagacgct 190 Pro Ala Cys Ser Val Asn Asn Pro Asp Ile Cys Gly gatgctccag gaccctctga accacgacgt tcgagca 227 <210> 77 <211> 60 <212> PRT
<213> Conus bandanus <400> 77 Met Phe Thr Met Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Ala Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Lys Asp Lys Ala Ser Asp Leu Val Ala Leu Thr Val Lys Gly Cys Cys Ser His Pro Ala Cys Ser Val Asn Asn Pro Asp Ile Cys Gly <210> 78 <211> 104 <212> DNA
<213> Conus bandanus <220>
<221> CDS
<222> (1)..(54) <400> 78 aaa gaa tgc tgt act cat cct gcc tgt cac gtg agt cat cca gaa ctc 48 Lys Glu Cys Cys Thr His Pro Ala Cys His Val Ser His Pro Glu Leu tgt ggt tgaaaagcga cgtgacgctc caggaccctc tgaaccacga cgttcgagca 104 Cys Gly <210> 79 <211> 18 <212> PRT
<213> Conus bandanus <400> 79 Lys Glu Cys Cys Thr His Pro Ala Cys His Val Ser His Pro Glu Leu Cys Gly <210> 80 <211> 206 <212> DNA
<213> Conus bandanus <220>
<221> CDS
<222> (1)..(171) <400> 80 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca act get gtt ctt cca 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Ala Val Leu Pro gtc act tta gat cgt gca tct gat gga agg aat gca gca gcc aac gcc 96 Val Thr Leu Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala aaa acg cct cgc ctg atc gcg cca ttc atc agg gat tat tgc tgt cat 144 Lys Thr Pro Arg Leu Ile Ala Pro Phe Ile Arg Asp Tyr Cys Cys His aga ggt ccc tgt atg gta tgg tgt ggt tgaagccgct gctgctccag 191 Arg Gly Pro Cys Met Val Trp Cys Gly gaccctctga accac 206 <210> 81 <211> 57 <212> PRT
<213> Conus bandanus <400> 81 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Ala Val Leu Pro Val Thr Leu Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Lys Thr Pro Arg Leu Ile Ala Pro Phe Ile Arg Asp Tyr Cys Cys His Arg Gly Pro Cys Met Val Trp Cys Gly <210> 82 <211> 174 <212> DNA
<213> Conus caracteristicus <220>
<221> CDS

<222> (1)..(171) <400> 82 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtg gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt get tct gat ggc agg aat gcc gca gcc aac gcg 96 Phe Thr Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala ttt gac ctg atc get ctg atc gcc agg caa aat tgc tgt agc att ccc 144 Phe Asp Leu Ile Ala Leu Ile Ala Arg Gln Asn Cys Cys Ser Ile Pro agc tgt tgg gag aaa tat aaa tgt agt taa 174 Ser Cys Trp Glu Lys Tyr Lys Cys Ser `55 <210> 83 <211> 57 <212> PRT
<213> Conus caracteristicus <400> 83 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Phe Asp Leu Ile Ala Leu Ile Ala Arg Gln Asn Cys Cys Ser Ile Pro Ser Cys Trp Glu Lys Tyr Lys Cys Ser <210> 84 <211> 219 <212> DNA
<213> Conus caracteristicus <220>
<221> CDS
<222> (1)..(189) <400> 84 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtg gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val. Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gcg tct gaa ggc agg aat get gca gcc aag gac 96 Phe Thr Ser Asp Arg Ala Ser Glu Gly Arg Asn Ala Ala Ala Lys Asp aaa gcg tct gac ctg gtg get ctg aca gtc agg gga tgc tgt gcc att 144 Lys Ala Ser Asp Leu Val Ala Leu Thr Val Arg Gly Cys Cys Ala Ile cgt gaa tgt cgc ttg cag aat gca gcg tat tgt ggt gga ata tac 189 Arg Glu Cys Arg Leu Gln A.sn Ala Ala Tyr Cys Gly Gly Ile Tyr tgatgctcca ggaccctctg aaccacgacg 219 <210> 85 <211> 63 <212> PRT
<213> Conus caracteristicus <400> 85 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Arg Ala Ser. Glu Gly Arg Asn Ala Ala Ala Lys Asp Lys Ala Ser Asp Leu Val Ala Leu Thr Val Arg Gly Cys Cys Ala Ile Arg Glu Cys Arg Leu Gln Asn Ala Ala Tyr Cys Gly Gly Ile Tyr 50 E3 F, 60 <210> 86 <211> 217 <212> DNA
<213> Conus tulipa <220>
<221> CDS
<222> (1)..(186) <400> 86 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat att gca act gag ggc agg aat gcc gca gcc aaa gcg 96 Phe Pro Ser Asp Ile Ala Thr Glu Gly Arg Asn Ala Ala Ala Lys Ala ttt gac ctg ata tct tcg at:c gtc aag aaa gga tgc tgt tcc cat cct 144 Phe Asp Leu Ile Ser Ser Ile Val Lys Lys Gly Cys Cys Ser His Pro gcc tgt tcg ggg aat aat cca gaa ttt tgt cgt caa ggt cgc 186 Ala Cys Ser Gly Asn Asn Piro Glu Phe Cys Arg Gin Gly Arg 50 `_>5 60 tgatgctcca ggaccctctg aaccacgacg t 217 <210> 87 <211> 62 <212> PRT
<213> Conus tulipa <400> 87 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Pro Ser Asp Ile Ala Thr Glu Gly Arg An Ala Ala Ala Lys Ala Phe Asp Leu Ile Ser Ser Ile Val Lys Lys Gly Cys Cys Ser His Pro Ala Cys Ser Gly Asn Asn Pro Glu Phe Cys Arg Gln Gly Arg <210> 88 <211> 217 <212> DNA
<213> Conus tulipa <220>
<221> CDS
<222> (1)..(186) <400> 88 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat ata gca act gag ggc agg aat gcc gca gcc aaa gcg 96 Phe Pro Ser Asp Ile Ala Thr Glu Gly Arg Asn Ala Ala Ala Lys Ala ttt gac ctg ata tct tcg atc gtc agg aaa gga tgc tgt tcc aat ccc 144 Phe Asp Leu Ile Ser Ser Ile Val Arg Lys Gly Cys Cys Ser Asn Pro gcc tgt gcg ggg aat aat cca cat gtt tgt cgt caa ggt cgc 186 Ala Cys Ala Gly Asn Asn Pro His Val Cys Arg Gln Gly Arg tgatgctcca ggaccctctg aaccacgacg t 217 <210> 89 <211> 62 <212> PRT
<213> Conus tulipa <400> 89 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Pro Ser Asp Ile Ala Thr Glu Gly Arg Asn Ala Ala Ala Lys Ala Phe Asp Leu Ile Ser Ser Ile Val Arg Lys Gly Cys Cys Ser Asn Pro Ala Cys Ala Gly Asn Asn Pro His Val Cys Arg Gln Gly Arg <210> 90 <211> 226 <212> DNA
<213> Conus sulcatus <220>
<221> CDS
<222> (1)..(195) <400> 90 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc aat tca gat cgt gat cca gca tta ggt ggc agg aat get gca gcc 96 Phe Asn Ser Asp Arg Asp Pro Ala Leu Gly Gly Arg Asn Ala Ala Ala aaa gcg tct gac aag atc gct tcg acc ctc aag aga aga gga tgc tgt 144 Lys Ala Ser Asp Lys Ile Ala Ser Thr Leu Lys Arg Arg Gly Cys Cys tcg tat ttt gac tgt aga atg atg ttt cca gaa atg tgt ggt tgg cga 192 Ser Tyr Phe Asp Cys Arg Met Met Phe Pro Glu Met Cys Gly Trp Arg ggc tgatgctcca ggaccctct.g aaccacgacg t 226 Gly <210> 91 <211> 65 <212> PRT
<213> Conus sulcatus <400> 91 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Asn Ser Asp Arg Asp Pro Ala Leu Gly Gly Arg Asn Ala Ala Ala Lys Ala Ser Asp Lys Ile Ala Ser Thr Leu Lys Arg Arg Gly Cys Cys Ser Tyr Phe Asp Cys Arg Met Met Phe Pro Glu Met Cys Gly Trp Arg Gly <210> 92 <211> 226 <212> DNA
<213> Conus sulcatus <220>
<221> CDS
<222> (1)..(195) <400> 92 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc aat tca gat cgt gat cca gca tta ggt ggc agg aat get gca gcc 96 Phe Asn Ser Asp Arg Asp Pro Ala Leu Gly Gly Arg Asn Ala Ala Ala ata gcg tct gac aag atc get tcg acc ctc agg aga gga gga tgc tgt 144 Ile Ala Ser Asp Lys Ile Ala Ser Thr Leu Arg Arg Gly Gly Cys Cys tct ttt cct gcc tgt aga aag tat cgt cca gaa atg tgt ggt gga cga 192 Ser Phe Pro Ala Cys Arg Lys Tyr Arg Pro Glu Met Cys Gly Gly Arg cgc tgatgctcca ggaccctctg aaccacgacg t 226 Arg <210> 93 <211> 65 <212> PRT
<213> Conus sulcatus <400> 93 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Asn Ser Asp Arg Asp Pro Ala Leu Gly Gly Arg Asn Ala Ala Ala Ile Ala Ser Asp Lys Ile Ala Ser Thr Leu Arg Arg Gly Gly Cys Cys Ser Phe Pro Ala Cys Arg Lys Tyr Arg Pro Glu Met Cys Gly Gly Arg Arg <210> 94 <211> 211 <212> DNA
<213> Conus sulcatus <220>
<221> CDS
<222> (1)..(180) <400> 94 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cat gaa tct gat cgc ggt gat gcc caa acc atc caa 96 Phe Thr Ser Asp His Glu Ser Asp Arg Gly Asp Ala Gln Thr Ile Gln gaa gtg ttt gag atg ttc get ctg gac agc gat gga tgc tgt tgg cat 144 Glu Val Phe Glu Met Phe Ala Leu Asp Ser Asp Gly Cys Cys Trp His cct get tgt ggc aga cac tat tgt ggt cga aga cgc tgatgctcca 190 Pro Ala Cys Gly Arg His Tyr Cys Gly Arg Arg Arg ggaccctctg aaccacgacg t 211 <210> 95 <211> 60 <212> PRT
<213> Conus sulcatus <400> 95 Met Phe Thr Val Phe Leu Leu Val Val Leu A:La Thr Thr Val Val Ser Phe Thr Ser Asp His Glu Ser Asp Arg Gly Asp Ala Gln Thr Ile Gln Glu Val Phe Glu Met Phe Ala Leu Asp Ser Asp Gly Cys Cys Trp His Pro Ala Cys Gly Arg His Tyr Cys Gly Arg Arg Arg <210> 96 <211> 202 <212> DNA
<213> Conus sulcatus <220>
<221> CDS
<222> (1)..(195) <400> 96 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc aat tca gat cgt gat cca gca tta ggt ggc agg aat get gca gcc 96 Phe Asn Ser Asp Arg Asp Pro Ala Leu Gly Gly Arq Asn Ala Ala Ala ata gcg tct gac aag atc get tcg acc ctc agg aga gga gga tgc tgt 144 Ile Ala Ser Asp Lys Ile Ala Ser Thr Leu Arg Arg Gly Gly Cys Cys tct ttt get gcc tgt aga aag tat cgt cca gaa atg tgt ggt gga cga 192 Ser Phe Ala Ala Cys Arg Lys Tyr Arg Pro Glu Met Cys Gly Gly Arg cgc tgatgct 202 Arg <210> 97 <211> 65 <212> PRT
<213> Conus sulcatus <400> 97 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Asn Ser Asp Arg Asp Pro Ala Leu Gly Gly Arg Asn Ala Ala Ala Ile Ala Ser Asp Lys Ile Ala Ser Thr Leu Arg Arg Gly Gly Cys Cys Ser Phe Ala Ala Cys Arg Lys Tyr Arg Pro Glu Met Cys Gly Gly Arg Arg <210> 98 <211> 220 <212> DNA
<213> Conus sulcatus <220>
<221> CDS
<222> (1)..(189) <400> 98 atg ttc acc gtg ttt ctg ttg gtt ctc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Leu Leu Ala Thr Thr Val Val Ser 1 5 1.0 15 ttc aat tca gat cgt gca tta ggt ggc agg aat get gca gcc aaa gcg 96 Phe Asn Ser Asp Arg Ala Leu Gly Gly Arg Asn Ala Ala Ala Lys Ala tct gac aag atc ctt tcg aac ctc agg aga gga gga tgc tgt ttt cat 144 Ser Asp Lys Ile Leu Ser Asn Leu Arg Arg Gly Gly Cys Cys Phe His cct gtc tgt tac atc aat ctt cta gaa atg tgt cgt caa cga ggc 189 Pro Val Cys Tyr Ile Asn Leu Leu Glu Met Cys Arg Gln Arg Gly tgatcgtcca ggaccctctg aaccacgacg t 220 <210> 99 <211> 63 <212> PRT
<213> Conus sulcatus <400> 99 Met Phe Thr Val Phe Leu Leu Val Leu Leu Ala Thr Thr Val Val Ser Phe Asn Ser Asp Arg Ala Leu Gly Gly Arg Asn Ala Ala Ala Lys Ala Ser Asp Lys Ile Leu Ser Asn Leu Arg Arg Gl.y Gly Cys Cys Phe His Pro Val Cys Tyr Ile Asn Leu Leu Glu Met Cys Arg Gln Arg Gly 50 `_S5 60 <210> 100 <211> 208 <212> DNA
<213> Conus consors <220>
<221> CDS

<222> (1)..(177) <400> 100 atg ttc acc gtg ttt ctg ttg gtt gtc ttg aca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Thr Thr Thr Val Val Ser ttc cct tca gat agt gca tct gat gtc agg gat gac gaa gcc aaa gac 96 Phe Pro Ser Asp Ser Ala Ser Asp Val Arg Asp Asp Glu Ala Lys Asp gaa agg tct gac atg tac aaa tcg aaa cgg aat gga cgc tgt tgc cat 144 Glu Arg Ser Asp Met Tyr Lys Ser Lys Arg Asn Gly Arg Cys Cys His cct gcc tgt ggc aaa cac ttt agt tgt gga cgc tgatgctcca ggaccctctg 197 Pro Ala Cys Gly Lys His Phe Ser Cys Gly Arg aaccacgacg t 208 <210> 101 <211> 59 <212> PRT
<213> Conus consors <400> 101 Met Phe Thr Val Phe Leu Leu Val Val Leu Thr Thr Thr Val Val Ser Phe Pro Ser Asp Ser Ala Ser Asp Val Arg Asp Asp Glu Ala Lys Asp Glu Arg Ser Asp Met Tyr Lys Ser Lys Arg Asn Gly Arg Cys Cys His Pro Ala Cys Gly Lys His Phe Ser Cys Gly Arg <210> 102 <211> 219 <212> DNA
<213> Conus stercusmuscarum <220>
<221> CDS
<222> (1) .. (189) <400> 102 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser tcc cct tca gat cgt gca tct gat ggc agg aat gcc gca gcc aac gag 96 Ser Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Glu aaa gcg tct gac gtg atc gcg ctg gcc ctc aag gga tgc tgt tcc aac 144 Lys Ala Ser Asp Val Ile Ala Leu Ala Leu Lys Gly Cys Cys Ser Asn cct gtc tgt cac ctg gag cat tca aac atg tgt ggt aga aga cgc 189 Pro Val Cys His Leu Glu His Ser Asn Met Cys Gly Arg Arg Arg tgatgctcca ggaccctctg aaccacgacg 219 <210> 103 <211> 63 <212> PRT
<213> Conus stercusmuscarum <400> 103 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Ser Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Glu Lys Ala Ser Asp Val Ile Ala Leu Ala Leu Lys Gly Cys Cys Ser Asn Pro Val Cys His Leu Glu His Ser Asn Met Cys Gly Arg Arg Arg <210> 104 <211> 248 <212> DNA
<213> Conus betulinus <220>
<221> CDS
<222> (1)..(180) <400> 104 atg ttc tcc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Ser Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser tcc act tca ggt ggt gca tct ggt ggc agg aag get gca gcc aaa gcg 96 Ser Thr Ser Gly Gly Ala Ser Gly Gly Arg Lys Ala Ala Ala Lys Ala tct aac cgg atc get ctg acc gtc agg agt gca aca tgc tgt aat tat 144 Ser Asn Arg Ile Ala Leu Thr Val Arg Ser Ala Thr Cys Cys Asn Tyr cct ccc tgt tac gag act tat cca gaa agt tgt ctg taacgtgaat 190 Pro Pro Cys Tyr Glu Thr Tyr Pro Glu Ser Cys Leu catccagagc tttgtggctg aagacactga tgctccagga ccctctgaac cacgacgt 248 <210> 105 <211> 60 <212> PRT
<213> Conus betulinus <400> 105 Met Phe Ser Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Ser Thr Ser Gly Gly Ala Ser Gly Gly Arg Lys Ala Ala Ala Lys Ala Ser Asn Arg Ile Ala Leu Thr Val Arg Ser Ala Thr Cys Cys Asn Tyr Pro Pro Cys Tyr Glu Thr Tyr Pro Glu Ser Cys Leu <210> 106 <211> 223 <212> DNA
<213> Conus betulinus <220>
<221> CDS
<222> (1)..(183) <400> 106 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtg gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt gca ttt cgt ggc agg aat cgc gca gcc gac gac 96 Phe Thr Ser Gly Arg Ala Phe Arg Gly Arg Asn Arg Ala Ala Asp Asp aaa agg tct gac ctg gcc get ctg agc gtc agg gga gga tgc tgt tcc 144 Lys Arg Ser Asp Leu Ala Ala Leu Ser Val Arg Gly Gly Cys Cys Ser cat cct gcc tgt gcg gtg aa.t cat cca gag ctt tgt ggc tgaagacgct 193 His Pro Ala Cys Ala Val Asn His Pro Glu Leu Cys Gly gatgccccag gaccctctga accacgacgt 223 <210> 107 <211> 61 <212> PRT
<213> Conus betulinus <400> 107 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Gly Arg Ala Phe Arg Gly Arg Asn Arg Ala Ala Asp Asp Lys Arg Ser Asp Leu Ala Ala Leu Ser Val Arg Gly Gly Cys Cys Ser His Pro Ala Cys Ala Val Asn His Pro Glu Leu Cys Gly <210> 108 <211> 248 <212> DNA
<213> Conus betulinus <220>
<221> CDS
<222> (1)..(180) <400> 108 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca ggt cgt gca tct ggt ggc agg aat get gca gcc aaa gcg 96 Phe Thr Ser Gly Arg Ala Ser Gly Gly Arg Asn Ala Ala Ala Lys Ala tct aac cgg atc get atg gcc atc agc agt gga gca tgc tgt gca tat 144 Ser Asn Arg Ile Ala Met Ala Ile Ser Ser Gly Ala Cys Cys Ala Tyr cct ccc tgt ttc gag get tat cca gaa aga tgt ctg taacgtgaat 190 Pro Pro Cys Phe Glu Ala Tyr Pro Glu Arg Cys Leu catccagacc tttgtggctg aagacgctga tgccccagga ccctctgaac cacgacgt 248 <210> 109 <211> 60 <212> PRT
<213> Conus betulinus <400> 109 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Gly Arg Ala Ser Gly Gly Arg Asn Ala Ala Ala Lys Ala Ser Asn Arg Ile Ala Met Ala Ile Ser Ser Gly Ala Cys Cys Ala Tyr Pro Pro Cys Phe Glu Ala Tyr Pro Glu Arg Cys Leu <210> 110 <211> 223 <212> DNA
<213> Conus betulinus <220>
<221> CDS
<222> (1)..(192) <400> 110 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca ttt; cgt ggc agg aat tcc gca gcc aac gac 96 Phe Thr Ser Asp Arg Ala Phe Arg Gly Arg Asn Ser Ala Ala Asn Asp aaa agg tct gac ctg gcc gut ctg agc gtc agg aga gga tgc tgc tcc 144 Lys Arg Ser Asp Leu Ala Ala Leu Ser Val Arg Arg Gly Cys Cys Ser cat ccc gcc tgt agc gtg aat cat cca gag ctt tgt ggt aga aga cgc 192 His Pro Ala Cys Ser Val Asn His Pro Glu Leu Cys Gly Arg Arg Arg tgatgcccca ggaccctctg aaccacgacg t 223 <210> 111 <211> 64 <212> PRT
<213> Conus betulinus <400> 111 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Arg Ala Phe Arg Gly Arq Asn Ser Ala Ala Asn Asp Lys Arg Ser Asp Leu Ala Ala Leu Ser Val Arg Arg Gly Cys Cys Ser His Pro Ala Cys Ser Val Asn His Pro Glu Leu Cys Gly Arg Arg Arg <210> 112 <211> 248 <212> DNA
<213> Conus betulinus <220>
<221> CDS
<222> (1)..(180) <400> 112 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tea ggt cgt gca tet ggt ggc agg aat get gca gee aaa gcg 96 Phe Thr Ser Gly Arg Ala Ser Gly Gly Arg Asn Ala Ala Ala Lys Ala tct aac egg ate get ctg ate gtc agg aat gca gaa tgc tgt tat tat 144 Ser Asn Arg Ile Ala Leu Ile Val Arg Asn Ala Glu Cys Cys Tyr Tyr ect ecc tgt tae gag get tat cca gaa att tgt ctg taacgtgaat 190 Pro Pro Cys Tyr Glu Ala Tyr Pro Glu Ile Cys Leu catccagacc tttgtggctg aagaccctga tgctccagga ccctctgaac cacgacgt 248 <210> 113 <211> 60 <212> PRT
<213> Conus betulinus <400> 113 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Gly Arg Ala Ser Gly Gly Arg Asn Ala Ala Ala Lys Ala Ser Asn Arg Ile Ala Leu Ile Val Arg Asn Ala Glu Cys Cys Tyr Tyr Pro Pro Cys Tyr Glu Ala Tyr Pro Glu Ile Cys Leu <210> 114 <211> 207 <212> DNA
<213> Conus pennaceus <220>
<221> CDS
<222> (1)..(168) <400> 114 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc att tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Ile Ser ttc act tca gat cgt gca tct gat ggc ggg aat gcc gca gcg tct gac 96 Phe Thr Ser Asp Arg Ala Ser Asp Gly Gly Asn Ala Ala Ala Ser Asp ctg atc get ctg acc atc aag gga tgc tgt tct cat cct ccc tgt gcc 144 Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser His Pro Pro Cys Ala atg aat aat cca gac tat tgt ggt tgacgacgct gatgctccag gaccctctga 198 Met Asn Asn Pro Asp Tyr Cys Gly accacgacg 207 <210> 115 <211> 56 <212> PRT
<213> Conus pennaceus <400> 115 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Ile Ser Phe Thr Ser Asp Arg Ala Ser Asp Gly Gly Asn Ala Ala Ala Ser Asp Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser His Pro Pro Cys Ala Met Asn Asn Pro Asp Tyr Cys Gly <210> 116 <211> 207 <212> DNA
<213> Conus pennaceus <220>
<221> CDS
<222> (1)..(168) <400> 116 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu A:La Thr Thr Val Val Ser ttc act tca gat cgt gca t.ct gat ggc ggg aat gcc gca atg tct gac 96 Phe Thr Ser Asp Arg Ala Ser Asp Gly Gly Asn Ala Ala Met Ser Asp ctg atc get ctg acc atc aag gga tgc tgt tct cat cct ccc tgt ttc 144 Leu Ile Ala Leu Thr Ile L's Gly Cys Cys Ser His Pro Pro Cys Phe ctg aat aat cca gac tat tgt ggt tgacgacgct gatgctccag gaccctctga 198 Leu Asn Asn Pro Asp Tyr Cys Gly accacgacg 207 <210> 117 <211> 56 <212> PRT
<213> Conus pennaceus <400> 117 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Arg Ala Sex- Asp Gly Gly Asn Ala Ala Met Ser Asp Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser His Pro Pro Cys Phe Leu Asn Asn Pro Asp Tyr Cys Gly <210> 118 <211> 210 <212> DNA
<213> Conus stercusmuscarum <220>
<221> CDS
<222> (1)..(171) <400> 118 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Lei..i Ala Thr Thr Val Val Ser ttc cct tca gat cgt gaa tct gat ggc gcg aat gac gaa gcc cgc acc 96 Phe Pro Ser Asp Arg Glu Ser Asp Gly Ala Asn Asp Glu Ala Arg Thr gac gag cct gag gag cac gga ccg gac agg aat gga tgc tgt agg aat 144 Asp Glu Pro Glu Glu His Gly Pro Asp Arg Asn Gly Cys Cys Arg Asn cct gcc tgt gag agc cac aga tgt ggt tgacgacgct gatgctccag 191 Pro Ala Cys Glu Ser His Arg Cys Gly gaccctctga accacgacg 210 <210> 119 <211> 57 <212> PRT
<213> Conus stercusmuscarum <400> 119 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Pro Ser Asp Arg Glu Ser Asp Gly Ala Asn Asp Glu Ala Arg Thr Asp Glu Pro Glu Glu His Gly Pro Asp Arg Asn Gly Cys Cys Arg Asn Pro Ala Cys Glu Ser His Arg Cys Gly <210> 120 <211> 210 <212> DNA
<213> Conus circumcisus <220>
<221> CDS
<222> (1) .. (180) <400> 120 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat cgt gca t(-,,t. gat ggc agg aat gcc gca gcc agc gac 96 Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Ser Asp aga gcg tct gac gcg gcc cac cag gga tgc tgt tcc aac cct gtc tgt 144 Arg Ala Ser Asp Ala Ala His Gln Gly Cys Cys Ser Asn Pro Val Cys cac gtg gaa cat cca gaa ctt tgt cgt aga aga cgc tgatgctcca 190 His Val Glu His Pro Glu Leu Cys Arg Arg Arg Arg ggaccctctg aaccacgacg 210 <210> 121 <211> 60 <212> PRT
<213> Conus circumcisus <400> 121 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Ser Asp Arg Ala Ser Asp Ala Ala His Gln Gly Cys Cys Ser Asn Pro Val Cys His Val Glu His Pro Glu Leu Cys Arg Arg Arg Arg <210> 122 <211> 213 <212> DNA
<213> Conus circumcisus <220>
<221> CDS
<222> (1)..(174) <400> 122 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca aat cgt gaa tot gat ggc gcg aat gcc gaa gtc cgc acc 96 Phe Pro Ser Asn Arg Glu Ser Asp Gly Ala Asn Ala Glu Val Arg Thr gac gag cct gag gag cac gac gaa ctg ggc ggg aat gga tgc tgt ggg 144 Asp Glu Pro Glu Glu His Asp Glu Leu Gly Gly Asn Gly Cys Cys Gly aat cct gac tgt acg agc cac agt tgt gat tgacgacgct gatgctccag 194 Asn Pro Asp Cys Thr Ser H:is Ser Cys Asp gaccctctga accacgacg 213 <210> 123 <211> 58 <212> PRT
<213> Conus circumcisus <400> 123 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Pro Ser Asn Arg Glu Ser Asp Gly Ala Asn Ala Glu Val Arg Thr Asp Glu Pro Glu Glu His Asp Glu Leu Gly Gly Asn Gly Cys Cys Gly Asn Pro Asp Cys Thr Ser His Ser Cys Asp <210> 124 <211> 207 <212> DNA
<213> Conus episcopatus <220>
<221> CDS
<222> (1)..(168) <400> 124 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca. acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca tct gat agc agg aag gac gca gcg tct ggc 96 Phe Thr Ser Asp Arg Ala Ser Asp Ser Arg Lys Asp Ala Ala Ser Gly ctg atc get ctg acc atc aag gga tgc tgt tct gat cct cgc tgt aac 144 Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser Asp Pro Arg Cys Asn atg aat aat cca gac tat tgt: ggt tgacgacgct gatgctccag gaccctctga 198 Met Asn Asn Pro Asp Tyr Cys Gly accacgacg 207 <210> 125 <211> 56 <212> PRT
<213> Conus episcopatus <400> 125 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Arg Ala Ser Asp Ser Arg Lys Asp Ala Ala Ser Gly Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser Asp Pro Arg Cys Asn Met Asn Asn Pro Asp Tyr Cys Gly <210> 126 <211> 213 <212> DNA
<213> Conus sponsalis <220>
<221> CDS
<222> (1)..(174) <400> 126 atg tcc acc gtg ttt ctg ttg gtt gtc ctc gca acc acc gtc gtt tcc 48 Met Ser Thr Val Phe Leu Lieu Val Val Leu Ala Thr Thr Val Val Ser ttc act gta gat cgt gca tct gat ggc agg gat gtc gca atc gac gac 96 Phe Thr Val Asp Arg Ala Sear Asp Gly Arg Asp Val Ala Ile Asp Asp aga ttg gtg tct ctc cct cag atc gcc cat get gac tgt tgt tcc gat 144 Arg Leu Val Ser Leu Pro Gin Ile Ala His Ala Asp Cys Cys Ser Asp cct gcc tgc aag cag acg ccc ggt tgt cgt taaagacgct gctgctccag 194 Pro Ala Cys Lys Gln Thr Pro Gly Cys Arg gaccctctga accacgacg 213 <210> 127 <211> 58 <212> PRT
<213> Conus sponsalis <400> 127 Met Ser Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Val Asp Arg Ala Ser Asp Gly Arg Asp Val Ala Ile Asp Asp Arg Leu Val Ser Leu Pro Gin Ile Ala His Ala Asp Cys Cys Ser Asp Pro Ala Cys Lys Gln Thr Pro Gly Cys Arg <210> 128 <211> 221 <212> DNA
<213> Conus sponsalis <220>
<221> CDS
<222> (1)..(168) <400> 128 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc get tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Ala Ser ttc att atc gat gat cca tct: gat ggc agg aat att gca gtc gac gac 96 Phe Ile Ile Asp Asp Pro Ser Asp Gly Arg Asn Ile Ala Val Asp Asp aga ggg ctt ttc tct acg ctc ttc cat get gat tgc tgt gaa aat cct 144 Arg Gly Leu Phe Ser Thr Leu Phe His Ala Asp Cys Cys Glu Asn Pro gcc tgt aga cac acg cag ggt tgt tgatctttgt tcttcaaaga cactgctggc 198 Ala Cys Arg His Thr Gln Gly Cys ccaggaccct ctgaaccacg acg 221 <210> 129 <211> 56 <212> PRT
<213> Conus sponsalis <400> 129 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Ala Ser Phe Ile Ile Asp Asp Pro Ser Asp Gly Arg Asn Ile Ala Val Asp Asp Arg Gly Leu Phe Ser Thr Leu Phe His Ala Asp Cys Cys Glu Asn Pro Ala Cys Arg His Thr Gln Gly Cys so 55 <210> 130 <211> 220 <212> DNA
<213> Conus dalii <220>
<221> CDS
<222> (1)..(180) <400> 130 atg ttc acc gtg ttt ctg tt:g gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Le:u Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca tt:t cgt ggc agg aat gcc gca gcc aaa gag 96 Phe Thr Ser Asp Arg Ala Phe Arg Gly Arg Asn Ala Ala Ala Lys Glu tct ggc ctg gtc ggt ctg acc gac aag acg cga gga tgc tgt tct cat 144 Ser Gly Leu Val Gly Leu Thr Asp Lys Thr Arg Gly Cys Cys Ser His cct gcc tgt aac gta gat cat cca gaa att tgt ggt tgaagacgct 190 Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Gly gatgctccag gaccctctga accacgacgt 220 <210> 131 <211> 60 <212> PRT
<213> Conus dalli <400> 131 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Arg Ala Phe Arg Gly Arg Asn Ala Ala Ala Lys Glu Ser Gly Leu Val Gly Leu Thr Asp Lys Thr Arg Gly Cys Cys Ser His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Gly <210> 132 <211> 208 <212> DNA
<213> Conus dalli <220>
<221> CDS
<222> (1)..(177) <400> 132 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat ggt gca tct gat gac agg aaa gcc get gcg tct gac 96 Phe Thr Ser Asp Gly Ala Ser Asp Asp Arg Lys Ala Ala Ala Ser Asp ctg ate act ctg acc atc aag gga tgc tgt tct cgt cct ccc tgt atc 144 Leu Ile Thr Leu Thr Ile Lys Gly Cys Cys Ser Arg Pro Pro Cys Ile gcg aat aat cca gac ttg tgt ggt cga cga cgc tgatgctcca ggaccctctg 197 Ala Asn Asn Pro Asp Leu Cys Gly Arg Arg Arg aaccacgacg t 208 <210> 133 <211> 59 <212> PRT
<213> Conus dalli <400> 133 Met Phe Thr Val Phe Leu Levu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Gly Ala Ser Asp Asp Arg Lys Ala Ala Ala Ser Asp Leu Ile Thr Leu Thr Ile Lys Gly Cys Cys Ser Arg Pro Pro Cys Ile Ala Asn Asn Pro Asp Leu Cys Gly Arg Arg Arg <210> 134 <211> 223 <212> DNA
<213> Conus dalli <220>
<221> CDS
<222> (1)..(192) <400> 134 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser tee act tea ggt cgt cgt gca ttt cat ggc agg aat gcc gca gcc aaa 96 Ser Thr Ser Gly Arg Arg Ala Phe His Gly Arg Asn Ala Ala Ala Lys gcg tct gga ctg gtc ggt ctg act gac agg aga cca caa tgc tgt agt 144 Ala Ser Gly Leu Val Gly Leu Thr Asp Arg Arg Pro Gln Cys Cys Ser gat cct cgc tgt aac gta ggt cat cca gaa ctt tgt ggt gga aga cgc 192 Asp Pro Arg Cys Asn Val Gly His Pro Glu Leu Cys Gly Gly Arg Arg tgatgctcca ggaccctctg aaccacaacg t 223 <210> 135 <211> 64 <212> PRT
<213> Conus dalli <400> 135 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Ser Thr Ser Gly Arg Arg Ala Phe His Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Gly Leu Thr Asp Arg Arg Pro Gln Cys Cys Ser Asp Pro Arg Cys Asn Val Gly His Pro Glu Leu Cys Gly Gly Arg Arg <210> 136 <211> 220 <212> DNA
<213> Conus dalli <220>
<221> CDS
<222> (1)..(189) <400> 136 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser tcc act tca ggt cgt gca ttt cat ggc agg aat gcc gca gcc aaa gcg 96 Ser Thr Ser Gly Arg Ala Phe His Gly Arg Asn Ala Ala Ala Lys Ala tct ggc ctg gtc ggt ctg acc gac aag agg caa gta tgc tgt agt gat 144 Ser Gly Leu Val Gly Leu Thr Asp Lys Arg Gln Val Cys Cys Ser Asp cct cgc tgt aac gta ggt cat cca gaa att tgt ggt gga aga cgc 189 Pro Arg Cys Asn Val Gly His Pro Glu Ile Cys Gly Gly Arg Arg tgatgctcca ggaccctctg aaccacgacg t 220 <210> 137 <211> 63 <212> PRT
<213> Conus dalli <400> 137 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Ser Thr Ser Gly Arg Ala Phe His Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Gly Leu Thr Asp Lys Arg Gln Val Cys Cys Ser Asp Pro Arg Cys Asn Val Gly His Pro Glu Ile Cys Gly Gly Arg Arg <210> 138 <211> 208 <212> DNA
<213> Conus achatinus <220>
<221> CDS
<222> (1)..(180) <400> 138 atg ttc acc gtg ttt ctg ttg gtt gtc ttg aca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Thr Thr Thr Val Val Ser ttc cct tca gat agt gca tct ggt ggc agg gat gac gag gcc aaa gac 96 Phe Pro Ser Asp Ser Ala Ser Gly Gly Arg Asp Asp Glu Ala Lys Asp gaa agg tct gac atg tac gaa ttg aaa cgg aat gga cgc tgt tgc cat 144 Glu Arg Ser Asp Met Tyr Glu Leu Lys Arg Asn Gly Arg Cys Cys His cct gcc tgt ggt ggc aaa tac gtt aaa tgt gga cgc tgatgctcca 190 Pro Ala Cys Gly Gly Lys Tyr Val Lys Cys Gly Arg ggaccctctc gaaccacg 208 <210> 139 <211> 60 <212> PRT
<213> Conus achatinus <400> 139 Met Phe Thr Val Phe Leu Leu Val Val Leu Thr Thr Thr Val Val Ser Phe Pro Ser Asp Ser Ala Ser Gly Gly Arg Asp Asp Glu Ala Lys Asp Glu Arg Ser Asp Met Tyr Glu Leu Lys Arg Asn Gly Arg Cys Cys His Pro Ala Cys Gly Gly Lys Tyr Val Lys Cys Gly Arg <210> 140 <211> 211 <212> DNA
<213> Conus bullatus <220>
<221> CDS
<222> (1)..(174) <400> 140 atg ttc acc gtg ttt ctg tt:g gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc tct aca gat gat gaa tct gat ggc tcg aat gaa gaa ccc agc gcc 96 Phe Ser Thr Asp Asp Glu Seer Asp Gly Ser Asn Glu Glu Pro Ser Ala gac cag act gcc agg tcc tca atg aac agg gcg cct gga tgc tgt aac 144 Asp Gln Thr Ala Arg Ser Ser Met Asn Arg Ala Pro Gly Cys Cys Asn aat cct gcc tgt gtg aag cac aga tgt gga tgacgctgat gctccaggac 194 Asn Pro Ala Cys Val Lys His Arg Cys Gly cctctgaacc acgacgt 211 <210> 141 <211> 58 <212> PRT
<213> Conus bullatus <400> 141 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Ser Thr Asp Asp Glu Ser Asp Gly Ser Asn Glu Glu Pro Ser Ala Asp Gln Thr Ala Arg Ser Ser Met Asn Arg Ala Pro Gly Cys Cys Asn Asn Pro Ala Cys Val Lys His Arg Cys Gly <210> 142 <211> 214 <212> DNA
<213> Conus bullatus <220>
<221> CDS
<222> (1)..(177) <400> 142 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc tct aca gat gat gaa tct gat ggc tcg aat gaa gaa ccc agc gcc 96 Phe Ser Thr Asp Asp Glu Ser Asp Gly Ser Asn Glu Glu Pro Ser Ala gac cag get gcc agg tcc gca atg aac agg ccg cct gga tgc tgt aac 144 Asp Gln Ala Ala Arg Ser Ala Met Asn Arg Pro Pro Gly Cys Cys Asn aat cct gcc tgt gtg aag cac aga tgt ggt gga tgacgctgat gctccaggac 197 Asn Pro Ala Cys Val Lys His Arg Cys Gly Gly cctctgaacc acgacgt 214 <210> 143 <211> 59 <212> PRT
<213> Conus bullatus <400> 143 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Ser Thr Asp Asp Glu Ser Asp Gly Ser Asn Glu Glu Pro Ser Ala Asp Gln Ala Ala Arg Ser Ala Met Asn Arg Pro Pro Gly Cys Cys Asn Asn Pro Ala Cys Val Lys His Arg Cys Gly Gly <210> 144 <211> 208 <212> DNA
<213> Conus bullatus <220>
<221> CDS
<222> (1)..(177) <400> 144 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat cgt gac tct gat ggc gcg gat gcc gaa gcc agt gac 96 Phe Pro Ser Asp Arg Asp Ser Asp Gly Ala Asp Ala Glu Ala Ser Asp gag cct gtt gag ttc gaa agg gac gag aat gga tgc tgt tgg aat cct 144 Glu Pro Val Glu Phe Glu Arg Asp Glu Asn Gly Cys Cys Trp Asn Pro tcc tgt ccg agg ccc aga tgt aca gga cga cgc taatgctcca ggaccctctg 197 Ser Cys Pro Arg Pro Arg Cys Thr Gly Arg Arg 50 aaccacgacg t 208 <210> 145 <211> 59 <212> PRT
<213> Conus bullatus <400> 145 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Pro Ser Asp Arg Asp Ser Asp Gly Ala Asp Ala Glu Ala Ser Asp Glu Pro Val Glu Phe Glu Arg Asp Glu Asn Gly Cys Cys Trp Asn Pro Ser Cys Pro Arg Pro Arg Cys Thr Gly Arg Arg <210> 146 <211> 211 <212> DNA
<213> Conus bullatus <220>
<221> CDS
<222> (1)..(180) <400> 146 atg ttc acc gtg ttt ctg tt:g gtt gtc ttg aca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Thr Thr Thr Val Val Ser 1 5 11) 15 ttc cct tca gat cgt gca tct gat ggc agg aat gcc gca gcc aac gac 96 Phe Pro Ser Asp Arg Ala Ser. Asp Gly Arg Asn Ala Ala Ala Asn Asp aaa gcg tct gac gtg gtc acg ctg gtc ctc aag gga tgc tgt tcc acc 144 Lys Ala Ser Asp Val Val Thr Leu Val Leu Lys Gly Cys Cys Ser Thr cct ccc tgt get gtg ctg tat tgt ggt aga aga cgc tgatgctcca 190 Pro Pro Cys Ala Val Leu Tyr Cys Gly Arg Arg Arg ggaccctctg aaccacgacg t 211 <210> 147 <211> 60 <212> PRT
<213> Conus bullatus <400> 147 Met Phe Thr Val Phe Leu Leu Val Val Leu Thr Thr Thr Val Val Ser Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Val Val Thr Leu Val Leu Lys Gly Cys Cys Ser Thr Pro Pro Cys Ala Val Leu Tyr Cys Gly Arg Arg Arg <210> 148 <211> 212 <212> DNA
<213> Conus distans <220>
<221> CDS
<222> (1)..(171) <400> 148 atg ttc acc gtg ttt ctg ttg gtt gtc ttc gca tcc tct gtc acc tta 48 Met Phe Thr Val Phe Leu Leu Val Val Phe Ala Ser Ser Val Thr Leu gat cgt gca tct tat ggc agg tat gcc tca ccc gtc gac aga gcg tct 96 Asp Arg Ala Ser Tyr Gly Arg Tyr Ala Ser Pro Val Asp Arg Ala Ser gcc ctg atc get cag gcc atc ctt cga gat tgc tgc tcc aat cct cct 144 Ala Leu Ile Ala Gln Ala Isle Leu Arg Asp Cys Cys Ser Asn Pro Pro tgt gcc cat aat aat cca gac tgt cgt taaagacgct gcttgctcca 191 Cys Ala His Asn Asn Pro Asp Cys Arg ggaccctctg aaccacgacg t 212 <210> 149 <211> 57 <212> PRT
<213> Conus distans <400> 149 Met Phe Thr Val Phe Leu Levu Val Val Phe Ala Ser Ser Val Thr Leu Asp Arg Ala Ser Tyr Gly Arg Tyr Ala Ser Pro Val Asp Arg Ala Ser Ala Leu Ile Ala Gln Ala Ile Leu Arg Asp Cys Cys Ser Asn Pro Pro Cys Ala His Asn Asn Pro Asp Cys Arg <210> 150 <211> 63 <212> DNA
<213> Conus textile <220>
<221> CDS
<222> (1)..(60) <400> 150 gga tgc tgt tct aat cct ccc tgt atc gcg aag aat cca cac atg tgt 48 Gly Cys Cys Ser Asn Pro Pro Cys Ile Ala Lys Asn Pro His Met Cys ggt gga aga cgc tga 63 Gly Gly Arg Arg <210> 151 <211> 20 <212> PRT
<213> Conus textile <400> 151 Gly Cys Cys Ser Asn Pro Pro Cys Ile Ala Lys Asn Pro His Met Cys 1 5 1.0 15 Gly Gly Arg Arg <210> 152 <211> 220 <212> DNA
<213> Conus consors <220>
<221> CDS
<222> (1)..(189) <400> 152 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc cct tca gat cgt gca tct gat ggc agg aat gcc gca gcc aac gac 96 Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp aaa gcg tct gac gtg atc acg ctg gcc ctc aag gga tgc tgt tcc aac 144 Lys Ala Ser Asp Val Ile Thr Leu Ala Leu Lys Gly Cys Cys Ser Asn cct gtc tgt cac ttg gag cat tca aac ctt tgt ggt aga aga cgc 189 Pro Val Cys His Leu Glu His Ser Asn Leu Cys Gly Arg Arg Arg tgatgctcca ggaccctctg aaccacgacg t 220 <210> 153 <211> 63 <212> PRT
<213> Conus consors <400> 153 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Pro Ser Asp Arg Ala Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Val Ile Thr Leu Ala Leu Lys Gly Cys Cys Ser Asn Pro Val Cys His Leu Glu His Ser Asn Leu Cys Gly Arg Arg Arg <210> 154 <211> 15 <212> PRT
<213> Conus musicus <220>
<221> PEPTIDE
<222> (4)..(12) <223> Xaa at residues 4, 11 and 12 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr. Xaa at residue 6 is Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (9)..(15) <223> Xaa at residues 9, 10 and 15 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys; Xaa at residue 14 is Trp (D or L) or halo-Trp.

<400> 154 Gly Cys Cys Xaa Asn Xaa Val Cys Xaa Xaa Xaa Xaa Cys Xaa Xaa <210> 155 <211> 16 <212> PRT
<213> Conus purpurascens <220>
<221> PEPTIDE
<222> (1)..(3) <223> Xaa at residue 1 is Gln or pyro-Glu; Xaa at residue 2 is Glu or gamma-carboxy-Glu; Xaa at residues 3 and 9 is Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (13) <223> Xaa at residue 13 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyi-Lys.
<400> 155 Xaa Xaa Xaa Gly Cys Cys Arg His Xaa Ala Cys Gly Xaa Asn Arg Cys <210> 156 <211> 13 <212> PRT
<213> Conus musicus <220>
<221> PEPTIDE
<222> (5)..(11) <223> Xaa at residues 5 and 11 is Pro or hydroxy-Pro.

<400> 156 Cys Cys Ala Asp Xaa Asp Cys Arg Phe Arg Xaa Gly Cys <210> 157 <211> 17 <212> PRT
<213> Conus musicus <220>
<221> PEPTIDE
<222> (4)..(13) <223> Xaa at residues 4 and 13 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O--sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr; Xaa at residues 6 and is Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (9) .. (17) <223> Xaa at residues 9 and 16 is Trp (D or L) or halo-Trp; Xaa at residues 11 and 17 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.
<400> 157 Gly Cys Cys Xaa Asn Xaa Ser Cys Xaa Xaa Xaa Thr Xaa Cys Ser Xaa Xaa <210> 158 <211> 13 <212> PRT
<213> Conus musicus <220>
<221> PEPTIDE
<222> (5)..(8) <223> Xaa at residue 5 is Pro or hydroxy-Pro; Xaa at residue 8 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethy:L-Lys.

<220>
<221> PEPTIDE
<222> (9)..(11) <223> Xaa at residue 9 is Glu or gamma-carboxy-Glu; Xaa at residue 11 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-su.lpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 158 Cys Cys Ser Asn Xaa Thr Cys Xaa Xaa Thr Xaa Gly Cys <210> 159 <211> 13 <212> PRT
<213> Conus musicus <220>
<221> PEPTIDE
<222> (5)..(11) <223> Xaa at residues 5 and 11 is Pro or hydroxy-Pro;
Xaa at residue 8 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.

<400> 159 Cys Cys Ala Asn Xaa Ile Cys Xaa Asn Thr Xaa Gly Cys <210> 160 <211> 13 <212> PRT
<213> Conus musicus <220>
<221> PEPTIDE
<222> (5) .. (8) <223> Xaa at residue 5 is Pro or hydroxy-Pro; Xaa at residue 8 is Lys, N'-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl.-]Lys.

<220>
<221> PEPTIDE
<222> (9) .. (11) <223> Xaa at residue 9 is Glu or gamma-carboxy-Glu; Xaa at residue 11 is Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<400> 160 Cys Cys Asn Asn Xaa Thr Cys Xaa Xaa Thr Xaa Gly Cys <210> 161 <211> 13 <212> PRT
<213> Conus musicus <220>
<221> PEPTIDE
<222> (5) .. (8) <223> Xaa at residue 5 is Pro or hydroxy-Pro; Xaa at residue 8 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N, N,N-trimethyl-Lys.

<220>
<221> PEPTIDE
<222> (9)..(11) <223> Xaa at residue 9 is Glu or gamma-carboxy-Glu; Xaa at residue 11 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-suipho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 161 Cys Cys Ser Asn Xaa Val Cys Xaa Xaa Thr Xaa Gly Cys <210> 162 <211> 17 <212> PRT
<213> Conus betulinus <220>
<221> PEPTIDE
<222> (6)..(14) <223> Xaa at residue 6 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr; Xaa at residues 7, 8 and 1.4 is Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.
<400> 162 Gly Gly Cys Cys Ser Xaa Xaa Xaa Cys Ile Ala Ser Asn Xaa Xaa Cys Gly <210> 163 <211> 15 <212> PRT
<213> Conus lividus <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 163 Gly Cys Cys Ser His Xaa Val Cys Ser Ala Met Ser Xaa Ile Cys <210> 164 <211> 15 <212> PRT
<213> Conus musicus <220>
<221> PEPTIDE
<222> (4)..(12) <223> Xaa at residues 4 and 12 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys; Xaa at residue 6 is Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (7)..(14) <223> Xaa at residues 7 and 14 is Tyr, mono-halo-Tyr, di-halo-Tyr, O-suipho-Tyr, O-phospho-Tyr or nitro-Tyr.

<400> 164 Gly Cys Cys Xaa Asn Xaa Xaa Cys Gly Ala Ser Xaa Thr Xaa Cys <210> 165 <211> 15 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (5)..(13) <223> Xaa at residue 5 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr; Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro.

<400> 165 Gly Cys Cys Ser Xaa Xaa Xaa Cys Phe Ala Thr Asn Xaa Asp Cys 1 5 1.0 15 <210> 166 <211> 17 <212> PRT
<213> Conus radiatus <220>
<221> PEPTIDE
<222> (6) .. (14) <223> Xaa at residue 6 is Tyr, nor-Tyr, mono-halo.-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr; Xaa at residues 7, 8 and 14 is Pro or hydroxy-Pro.

<400> 166 Gly Gly Cys Cys Ser Xaa Xaa Xaa Cys Ile Ala Asn Asn Xaa Leu Cys Ala <210> 167 <211> 17 <212> PRT
<213> Conus radiatus <220>
<221> PEPTIDE
<222> (6).. (14) <223> Xaa at residue 6 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr; Xaa at residues 7, 8 and 14 is Pro or hydroxy-Pro.

<400> 167 Gly Gly Cys Cys Ser Xaa Xaa Xaa Cys Ile Ala Asn Asn Xaa Phe Cys Ala <210> 168 <211> 16 <212> PRT
<213> Conus virgo <220>
<221> PEPTIDE
<222> (6) .. (13) <223> Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro.
<400> 168 Asp Cys Cys Ser Asn Xaa Xaa Cys Ser Gin Asn Asn Xaa Asp Cys Met <210> 169 <211> 16 <212> PRT
<213> Conus virgo <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro.
<400> 169 Asp Cys Cys Ser Asn Xaa Xaa Cys Ala His Asn Asn Xaa Asp Cys Arg <210> 170 <211> 20 <212> PRT
<213> Conus achatinus <220>
<221> PEPTIDE
<222> (1)..(14) <223> Xaa at residues 1, -1 and 14 is Glu or gamma-carboxy-Glu; Xaa at residue 6 is Pro or hydroxy-Pro.

<400> 170 Xaa Cys Cys Thr Asn Xaa Val Cys His Ala Xaa His Gln Xaa Leu Cys Ala Arg Arg Arg <210> 171 <211> 16 <212> PRT
<213> Conus achatinus <220>
<221> PEPTIDE
<222> (6)..(10) <223> Xaa at residue 6 is Pro or hydroxy-Pro; Xaa at residue 10 is Glu or gamma-carboxy-Glu.

<400> 171 Gly Cys Cys Ser Asn Xaa Val Cys His Leu Xaa His Ser Asn Leu Cys <210> 172 <211> 20 <212> PRT
<213> Conus achatinus <220>
<221> PEPTIDE
<222> (1)..(14) <223> Xaa at residues 1, 11 and 14 is Glu or gamma-carboxy-Glu; Xaa at residue 6 is Pro or hydroxy-Pro.

<400> 172 Xaa Cys Cys Thr Asn Xaa Val Cys His Val Xaa His Gln Xaa Leu Cys Ala Arg Arg Arg <210> 173 <211> 17 <212> PRT
<213> Conus ammiralis <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residue 1 is Gln or pyro-Glu; Xaa at residues 2 and 15 is Glu or gamma-carboxy-Glu; Xaa at residue 6 is Tyr, nor--Tyr, mono-.halo-Tyr, di-halo-Tyr, O-suipho-Tyr..

<220>
<221> PEPTIDE
<222> (6) .. (14) <223> Xaa at residue 6 is also 0-phopho-Tyr or nitro-Tyr;
Xaa at residues 7 and 14 is Pro or hydroxy-Pro.
<400> 173 Xaa Xaa Cys Cys Ser Xaa Xaa Ala Cys Asn Leu Asp His Xaa Xaa Leu Cys <210> 174 <211> 18 <212> PRT
<213> Conus ammiralis <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residues 1,. 7 and 14 is Pro or hydroxy-Pro;
Xaa at residues 2 and 15 is G1u or gamma-carboxy-Glu.

<400> 174 Xaa Xaa Cys Cys Ser Asp Xaa Arg Cys Asn Ser Thr His Xaa Xaa Leu 1 5 1.0 15 Cys Gly <210> 175 <211> 21 <212> PRT

?9 <213> Conus arenatus <220>
<221> PEPTIDE
<222> (7)..(12) <223> Xaa at residues 7 and 8 is Pro or hydroxy-Pro; Xaa at residue 10 is Trp (D or L) or halo-Trp; Xaa at residues 11 and 12 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl--Lys.
<220>
<221> PEPTIDE
<222> (13) .. (19) <223> Xaa at residue 13 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-su.pho-Tyr, 0-phospho-Tyr or nitro-Tyr ; Xaa at residue 19 is Glu or gamma-carboxy-Glu.

<400> 175 Leu Asn Cys Cys Met Ile Xaa Xaa Cys Xaa Xaa Xaa Xaa Gly Asp Arg Cys Ser Xaa Val Arg <210> 176 <211> 22 <212> PRT
<213> Conus arenatus <220>
<221> PEPTIDE
<222> (9)..(20) <223> Xaa at residue 9 is Pro or hydroxy-Pro; Xaa at residues 12 and 20 is Glu or gamma-carboxy-Glu.
<220>
<221> PEPTIDE
<222> (14) <223> Xaa at residue 14 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.
<400> 176 Ala Phe Gly Cys Cys Asp Leu Ile Xaa Cys Leu Xaa Arg Xaa Gly Asn Arg Cys Asn Xaa Val His <210> 177 <211> 21 <212> PRT
<213> Conus arenatus <220>
<221> PEPTIDE
<222> (8)..(16) <223> Xaa at residue 8 is Pro or hydroxy-Pro; Xaa at residue 10 is Trp (D or L) or halo-=Trp; Xaa at residues 12 and 16 is Lys, N-methyl.-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.

<220>
<221> PEPTIDE
<222> (11)..(19) <223> Xaa at residues 1.1 and 19 is Glu. or gamma-carboxy-Glu; Xaa at residue 1:3 is Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 177 Leu Gly Cys Cys Asn Val Thr Xaa Cys Xaa Xaa Xaa Xaa Gly Asp Xaa Cys Asn Xaa Val Arg <210> 178 <211> 20 <212> PRT
<213> Conus arenatus <220>
<221> PEPTIDE
<222> (2)..(14) <223> Xaa at residue 2 is Glu or gamma-carboxy-Glu; Xaa at residues 7 and 14 is Pro or hydroxy-Pro.

<400> 178 Asp Xaa Cys Cys Ser Asn Xaa Ala Cys Arg Val Asn Asn Xaa His Val Cys Arg Arg Arg <210> 179 <211> 21 <212> PRT
<213> Conus arenatus <220>
<221> PEPTIDE
<222> (7)..(12) <223> Xaa at residue 7 is Pro or hydroxy-Pro; Xaa at residue 10 is Trp (D or L) or halo-Trp; Xaa at residue 12 is Glu or gamma-carboxy-Glu.

<220>
<221> PEPTIDE
<222> (13)..(19) <223> Xaa at residue 13 is Tyr, nor-Tyr, mono-halo-Tyr,di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr;
Xaa at residues 14 and 19 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N, N,N-trimethyl-Lys.

<400> 179 Leu Asn Cys Cys Ser Ile Xaa Gly Cys Xaa Asn Xaa Xaa Xaa Asp Arg 1 5 1.0 15 Cys Ser Xaa Val Arg <210> 180 <211> 18 <212> PRT
<213> Conus aurisiacus <220>
<221> PEPTIDE
<222> (7)..(14) <223> Xaa at residues 7 and 14 is Pro or hydroxy-Pro;
Xaa at residue 10 is Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<400> 180 Gly Gly Cys Cys Ser His Xaa Val Cys Xaa Phe Asn Asn Xaa Gln Met Cys Arg <210> 181 <211> 18 <212> PRT
<213> Conus aurisiacus <220>
<221> PEPTIDE
<222> (7)..(14) <223> Xaa at residues 7 and 14 is Pro or hydroxy-Pro.
<400> 181 Gly Gly Cys Cys Ser His Xaa Val Cys Asn Leu Asn Asn Xaa Gln Met Cys Arg <210> 182 <211> 17 <212> PRT
<213> Conus bandanus <220>
<221> PEPTIDE
<222> (6)..(15) <223> Xaa at residues 6 and 7 is Pro or hydroxy-Pro; Xaa at residues 9 and 15 is Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 182 Gly Cys Cys Ser His Xaa Xaa Cys Xaa Ala Asn Asn Gln Ala Xaa Cys Asn <210> 183 <211> 17 <212> PRT
<213> Conus betulinus <220>
<221> PEPTIDE
<222> (7)..(15) <223> Xaa at residues 7 and 14 is Pro and hydroxy-Pro;
Xaa at residue 15 is Glu or gamma-carboxy-Glu.
<400> 183 Gly Gly Cys Cys Ser His Xaa Ala Cys Ser Val Thr His Xaa Xaa Leu Cys <210> 184 <211> 18 <212> PRT
<213> Conus betulinus <220>
<221> PEPTIDE
<222> (6)..(7) <223> Xaa at residue 6 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr; Xaa at residue 7 is Pro and hydroxy-Pro.

<220>
<221> PEPTIDE

<222> (12) <223> Xaa at residue 12 is Glu or gamma-carboxy-Glu.
<400> 184 Gly Gly Cys Cys Ser Xaa Xaa Ala Cys Ser Val Xaa His Gln Asp Leu Cys Asp <210> 185 <211> 25 <212> PRT
<213> Conus caracteristicas <220>
<221> PEPTIDE
<222> (8)..(22) <223> Xaa at residues 8 and 22 is Pro or hydroxy-Pro;
Xaa at residue 10 is Trp (D or L) or halo-Trp.
<220>
<221> PEPTIDE
<222> (13) .. (19) <223> Xaa at residue 13 is Tyr, nor--Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr;
Xaa at residues 15, 16 and 19 is Glu or gamma-carboxy-Glu.

<400> 185 Val Ser Cys Cys Val Val Arg Xaa Cys Xaa Ile Arg Xaa Gin Xaa Xaa Cys Leu Xaa Ala Asp Xaa Arg Thr Leu <210> 186 <211> 21 <212> PRT
<213> Conus caracteristicas <220>
<221> PEPTIDE
<222> (1)..(19) <223> Xaa at residue 1 is Gln or pyro-Glu; Xaa at residue 7 is Pro or hydroxy-Pro; Xaa at residue 10 is Trp (D or L) or halo-Trp; Xaa at residues 11 and 19 is Glu or gamma-carboxy-Glu.

<220>
<221> PEPTIDE
<222> (12)..(16) <223> Xaa at residues 12 and 16 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys; Xaa at residue 13 is Tyr, mono-halo-Tyr, d_i-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 186 Xaa Asn Cys Cys Ser Ile Xaa Gly Cys Xaa Xaa Xaa Xaa Gly Asp Xaa Cys Ser Xaa Val Arg <210> 187 <211> 16 <212> PRT
<213> Conus catus <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residue 11 is Glu or gamma-carboxy-Glu.
<400> 187 Gly Cys Cys Ser Asn Xaa Val Cys His Leu Xaa His Xaa Asn Ala Cys <210> 188 <211> 17 <212> PRT
<213> Conus catus <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residue 9 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<400> 188 Gly Cys Cys Ser Asn Xaa Ile Cys Xaa Phe Asn Asn Xaa Arg Ile Cys Arg <210> 189 <211> 17 <212> PRT
<213> Conus episcopatus <220>

<221> PEPTIDE
<222> (1)..(14) <223> Xaa at residues 1 and 14 is Glu or gamma-carboxy-Glu; Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro; Xaa at residue 10 is Trp (D or L) or halo-Trp.

<220>
<221> PEPTIDE
<222> (11) <223> Xaa at residue 11 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl.-Lys.
<400> 189 Xaa Cys Cys Ser Gln Xaa Xaa Cys Arg Xaa Xaa His Xaa Xaa Leu Cys Ser <210> 190 <211> 16 <212> PRT
<213> Conus geographus <220>
<221> PEPTIDE
<222> (6) <223> Xaa at residue 6 is Pro or hydroxy-Pro.
<400> 190 Gly Cys Cys Ser His Xaa Ala Cys Ala Gly Asn Asn Gln His Ile Cys <210> 191 <211> 18 <212> PRT
<213> Conus geographus <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 191 Gly Cys Cys Ala Val Xaa Seer Cys Arg Leu Arg Asn Xaa Asp Leu Cys Gly Gly <210> 192 <211> 16 <212> PRT
<213> Conus imperialis <220>
<221> NP BIND
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 192 Gly Cys Cys Ser His Xaa Ala Cys Asn Val Asn Asn Xaa His Ile Cys <210> 193 <211> 20 <212> PRT
<213> Conus lividus <220>
<221> PEPTIDE
<222> (2)..(10) <223> Xaa at residues 2, 7, 9 and 10 is Pro or hydroxy-Pro; Xaa at residues 3 and 4 is Glu or gamma-carboxy-Glu.

<400> 193 Thr Xaa Xaa Xaa Cys Cys Xaa Asn Xaa Xaa Cys Phe Ala Thr Asn Ser Asp Ile Cys Gly <210> 194 <211> 17 <212> PRT
<213> Conus lividus <220>
<221> PEPTIDE
<222> (7)..(12) <223> Xaa at residue 7 is Pro or hydroxy-Pro; Xaa at residue 12 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N, N,N-trimethyl-Lys.

<400> 194 Asp Ala Cys Cys Ser Asp Xaa. Arg Cys Ser Gly Xaa His Gln Asp Leu Cys <210> 195 <211> 17 <212> PRT
<213> Conus lividus <220>
<221> PEPTIDE
<222> (1) .. (7) <223> Xaa at residue 1 is Glu or gamma-carboxy-Glu; Xaa at residue 7 is Pro or hydroxy-Pro.

<400> 195 Xaa Asp Cys Cys Ser Asp Xaa Arg Cys Ser Val Gly His Gln Asp Leu Cys <210> 196 <211> 16 <212> PRT
<213> Conus lividus <220>
<221> PEPTIDE
<222> (6) <223> Xaa at residue 6 is Pro or hydroxy-Pro.
<400> 196 Gly Cys Cys Ser His Xaa Ala Cys Ala Gly Ser Asn Ala His Ile Cys <210> 197 <211> 17 <212> PRT
<213> Conus lividus <220>
<221> PEPTIDE
<222> (1) .. (7) <223> Xaa at residue 1 is Glu or gamma-carboxy-Glu; Xaa at residue 7 is Pro or hydroxy-Pro.

<400> 197 Xaa Asp Cys Cys Ser Asp Xaa Arg Cys Ser Val Gly His Gln Asp Met Cys <210> 198 <211> 16 <212> PRT

<213> Conus lividus <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 198 Gly Cys Cys Ser His Xaa Ala Cys Ala Gly Asn Asn Xaa His Ile Cys <210> 199 <211> 17 <212> PRT
<213> Conus lividus <220>
<221> PEPTIDE
<222> (6)..(14) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residue 14 is Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<400> 199 Gly Cys Cys Gly Asn Xaa Ser Cys Ser Ile His Ile Xaa Xaa Val Cys Asn <210> 200 <211> 21 <212> PRT
<213> Conus lividus <220>
<221> PEPTIDE
<222> (4)..(5) <223> Xaa at residues 4 and 5 is Glu or gamma-carboxy-Glu.
<400> 200 Thr Asp Ser Xaa Xaa Cys Cys Leu Asp Ser Arg Cys Ala Gly Gln His Gln Asp Leu Cys Gly <210> 201 <211> 17 <212> PRT

<213> Conus marmoreus <220>
<221> PEPTIDE
<222> (6)..(15) <223> Xaa at residues 6 and 7 is Pro or hydroxy-Pro; Xaa at residues 9 and 1!5 is Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulph.ho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 201 Gly Cys Cys Ser Asn Xaa Xaa Cys Xaa Ala Asn Asn Gln Ala Xaa Cys Asn <210> 202 <211> 16 <212> PRT
<213> Conus marmoreus <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 202 Gly Cys Cys Ser His Xaa Ala Cys Ser Val Asn Asn Xaa Asp Ile Cys <210> 203 <211> 18 <212> PRT
<213> Conus musicus <220>
<221> PEPTIDE
<222> (2)..(15) <223> Xaa at residues 2 and 12 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys; Xaa at residue 14 is Pro or hydroxy-Pro.

<220>
<221> PEPTIDE
<222> (16) <223> Xaa at residue 16 is Tyr, mono-halo-Tyr, di-halo-Tyr, 0-suipho-Tyr, O-phospho-Tyr or nitro-Tyr.

<400> 203 Gly Xaa Cys Cys Ile Asn Asp Ala Cys Arg Ser Xaa His Xaa Gln Xaa Cys Ser <210> 204 <211> 17 <212> PRT
<213> Conus musicus <220>
<221> PEPTIDE
<222> (4) .. (15) <223> Xaa at residues 4 and 15 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr; Xaa at residue 13 is Pro or hydroxy-Pro.

<400> 204 Gly Cys Cys Xaa Asn Ile Ala Cys Arg Ile Asn Asn Xaa Arg Xaa Cys Arg <210> 205 <211> 17 <212> PRT
<213> Conus obscurus <220>
<221> PEPTIDE
<222> (6)..(15) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residues 12 and 15 is Tyr, nor-Tyr, mono-halo-Tyr, di halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<220>
<221> PEPTIDE
<222> (14) <223> Xaa at residue 14 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.
<400> 205 Gly Cys Cys Ser His Xaa Val Cys Arg Phe Asn Xaa Xaa Xaa Xaa Cys 1 5 ]0 15 Gly <210> 206 <211> 18 <212> PRT

<213> Conus obscurus <220>
<221> PEPTIDE
<222> (2) .. (14) <223> Xaa at residue 2 is Glu or gamma-carboxy-Glu; Xaa at residues 7, 8 and 14 is Pro or hydroxy-Pro;
<220>
<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.
<400> 206 Asp Xaa Cys Cys Ala Ser Xaa Xaa Cys Arg Leu Asn Asn Xaa Xaa Val Cys His <210> 207 <211> 19 <212> PRT
<213> Conus obscurus <220>
<221> PEPTIDE
<222> (6)..(18) <223> Xaa at residue 6 is Pro or hydroxy-Pro; Xaa at residue 9 is Trp (D or L) or halo-Trp; Xaa at residues 14 and 18 is Glu or gamma-carboxy-Glu.
<220>
<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<400> 207 Gly Cys Cys Ser Asn Xaa Val Cys Xaa Gin Asn Asn Ala Xaa Xaa Cys Arg Xaa Ser <210> 208 <211> 16 <212> PRT
<213> Conus obscurus <220>

<221> PEPTIDE
<222> (6)..(15) <223> Xaa at residues 6 and 7 is Pro or hydroxy-Pro; Xaa at residue 15 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<400> 208 Gly Cys Cys Ser His Xaa Xaa Cys Ala Gin Asn Asn Gln Asp Xaa Cys <210> 209 <211> 19 <212> PRT
<213> Conus obscurus <220>
<221> PEPTIDE
<222> (6)..(18) <223> Xaa at residue 6 is Pro or hydroxy-Pro; Xaa at residues 14 and 18 is Glu or gamma-carboxy-Glu;
<220>
<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.
<400> 209 Gly Cys Cys Ser His Xaa A:La Cys Ser Gly Asn Asn Arg Xaa Xaa Cys Arg Xaa Ser <210> 210 <211> 18 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (2)..(14) <223> Xaa at residues 2, 7 and 14 is Pro or hydroxy-Pro;
Xaa at residue 6 is, Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<220>
<221> PEPTIDE
<222> (15) <223> Xaa at residue 15 is Glu or gamma-carboxy-Glu.

<400> 210 Asp Xaa Cys Cys Ser Xaa Xaa Asp Cys Glr Ala Asn His Xaa Xaa Ile Cys Gly <210> 211 <211> 17 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (1)..(14) <223> Xaa at residues 1 and 14 is Glu or gamma-carboxy-Glu; Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro; Xaa at residue 1.0 is Trp (D or L) or halo-Trp.

<220>
<221> PEPTIDE
<222> (11) <223> Xaa at residue 11 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.
<400> 211 Xaa Cys Cys Ser Gln Xaa Xaa Cys Arg Xaa Xaa His Xaa Xaa Leu Cys Ser <210> 212 <211> 16 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (6) .. (13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 212 Gly Cys Cys Ser His Xaa Ala Cys Ala Gly Asn Asn Xaa His Ile Cys <210> 213 <211> 16 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (6)..(15) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residue 15 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 213 Gly Cys Cys Ser Asp Xaa Ser Cys Asn Val Asn Asn Xaa Asp Xaa Cys <210> 214 <211> 18 <212> PRT
<213> Conus omaria <220>
<221> PEPTIDE
<222> (1)..(7) <223> Xaa at residues 1 and 2 is Glu or gamma-carboxy-Glu; Xaa at residue 7 is Pro or hydroxy-Pro.

<400> 214 Xaa Xaa Cys Cys Ser Asp Xaa Arg Cys Ser Val Gly His Gln Asp Met Cys Arg <210> 215 <211> 17 <212> PRT
<213> Conus purpurascens <220>
<221> PEPTIDE
<222> (7)..(15) <223> Xaa at residue 7 is Pro or hydroxy-Pro; Xaa at residue 15 is Glu or gamma-carboxy-Glu.

<400> 215 Gly Gly Cys Cys Ser Asn Xaa Ala Cys Leu Val Asn His Leu Xaa Met Cys <210> 216 <211> 18 <212> PRT

<213> Conus purpurascens <220>
<221> PEPTIDE
<222> (3)..(15) <223> Xaa at residues 3, 8 and 15 is Pro or hydroxy-Pro.
<400> 216 Arg Asp Xaa Cys Cys Phe Asn Xaa Ala Cys Asn Val Asn Asn Xaa Gln 1 5 1r) 15 Ile Cys <210> 217 <211> 21 <212> PRT
<213> Conus purpurascens <220>
<221> PEPTIDE
<222> (5) .. (8) <223> Xaa at residue 5 is Pro or hydroxy-Pro; Xaa at residue 8 is Trp (D or L) or halo-Trp.

<400> 217 Cys Cys Ser Asp Xaa Ser Cys Xaa Arg Leu His Ser Leu Ala Cys Thr Gly Ile Val Asn Arg <210> 218 <211> 16 <212> PRT
<213> Conus purpurascens <220>
<221> PEPTIDE
<222> (5) <223> Xaa at residue 5 is Pro or hydroxy-Pro.
<400> 218 Cys Cys Thr Asn Xaa Ala Cys Leu Val Asn Asri Ile Arg Phe Cys Gly 1 5 1.0 15 <210> 219 <211> 18 <212> PRT
<213> Conus regius <220>

<221> PEPTIDE
<222> (2)..(7) <223> Xaa at residue 2 is Glu or gamma-carboxy-Glu; Xaa at residue 7 is Pro or hydroxy-Pro.

<400> 219 Asp Xaa Cys Cys Ser Asp Xaa Arg Cys His Gly Asn Asn Arg Asp His Cys Ala <210> 220 <211> 17 <212> PRT
<213> Conus regius <220>
<221> PEPTIDE
<222> (6) .. (13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 220 Asp Cys Cys Ser His Xaa Leu Cys Arg Leu Phe Val Xaa Gly Leu Cys Ile <210> 221 <211> 17 <212> PRT
<213> Conus regius <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residue 9 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.

<220>
<221> PEPTIDE
<222> (12) <223> Xaa at residue 12 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, 0-phospho-Tyr or nitro-Tyr.

<400> 221 Gly Cys Cys Ser His Xaa Val Cys Xaa Val Arg Xaa Xaa Asp Leu Cys Arg <210> 222 <211> 16 <212> PRT
<213> Conus regius <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6"an.d 13 is Pro or hydroxy-Pro.
<400> 222 Gly Cys Cys Ser His Xaa Ala Cys Asn Val Asn Asn Xaa His Ile Cys <210> 223 <211> 16 <212> PRT
<213> Conus regius <220>
<221> PEPTIDE
<222> (6)..(12) <223> Xaa at residue 6 is Pro or hydroxy-Pro; Xaa at residue 12 is Tyr, nor-Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.

<220>
<221> PEPTIDE
<222> (9) <223> Xaa at residue 9 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.
<400> 223 Gly Cys Cys Ser His Xaa Val Cys Xaa Val Arg Xaa Ser Asp Met Cys <210> 224 <211> 17 <212> PRT
<213> Conus stercusmusca.rum <220>
<221> PEPTIDE
<222> (7)..(14) <223> Xaa at residues 7 and 14 is Pro or hydroxy-Pro;
Xaa at residue 10 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.

<400> 224 Gly Gly Cys Cys Ser His Xaa Ala Cys Xaa Val His Phe Xaa His Ser Cys <210> 225 <211> 20 <212> PRT
<213> Conus stercusmusca.rum <220>
<221> PEPTIDE
<222> (6)..(14) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro;
Xaa at residue 14 is Glu or gamma-carboxy-Glu.
<400> 225 Val Cys Cys Ser Asn Xaa Val Cys His Val Asp His Xaa Xaa Leu Cys Arg Arg Arg Arg <210> 226 <211> 17 <212> PRT
<213> Conus striatus <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 226 Gly Cys Cys Ser His Xaa Val Cys Asn Leu Ser Asn Xaa Gln Ile Cys Arg <210> 227 <211> 18 <212> PRT
<213> Conus textile <220>
<221> PEPTIDE
<222> (1)..(15) <223> Xaa at residue 1 is Gin or pyro-Glu; Xaa at residues 2 and 15 is Glu or gamma-carboxy-Glu; Xaa at residues 7 and :L4 is Pro or hydroxy-Pro.

<400> 227 Xaa Xaa Cys Cys Ser His Xaa Ala Cys Asn Val Asp His Xaa Xaa Ile Cys Arg <210> 228 <211> 17 <212> PRT
<213> Conus tulipa <220>
<221> PEPTIDE
<222> (6) <223> Xaa at residue 6 is Pro or hydroxy-Pro.
<400> 228 Gly Cys Cys Ser Asn Xaa Ala Cys Leu Val Asn His Ile Arg Phe Cys Gly <210> 229 <211> 17 <212> PRT
<213> Conus virgo <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6 and 13 is Pro or hydroxy-Pro.
<400> 229 Asp Cys Cys Asp Asp Xaa Ala Cys Thr Val Asn Asn Xaa Gly Leu Cys Thr <210> 230 <211> 20 <212> PRT
<213> Conus textile <220>
<221> PEPTIDE
<222> (6)..(13) <223> Xaa at residues 6, 7 and 13 is Pro or hydroxy-Pro;
Xaa at residue 11 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.

<400> 230 Gly Cys Cys Ser Asn Xaa Xaa Cys Ile Ala Xaa Asn Xaa His Met Cys Gly Gly Arg Arg <210> 231 <211> 18 <212> PRT
<213> Conus geographus <220>
<221> PEPTIDE
<222> (5) .. (8) <223> Xaa at residue 5 is Pro or hydroxy-Pro; Xaa at residue 8 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, 0-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr.
<220>
<221> PEPTIDE
<222> (9)..(14) <223> Xaa at residue 9 is Glu or gamma-carboxy--Glu; Xaa at residues 10, 11, 12 and 14 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl--Lys.

<400> 231 Cys Cys Thr Ile Xaa Ser Cys Xaa Xaa Xaa Xaa Xaa Ile Xaa Ala Cys Val Phe <210> 232 <211> 18 <212> PRT
<213> Conus regius <220>
<221> PEPTIDE
<222> (6)..(16) <223> Xaa at residues 6 and 16 is Pro or hydroxy-Pro;
Xaa at residue 13 is Lys, N-methyl-Lys, N,N-dimethyl-Lys or N,N,N-trimethyl-Lys.

<400> 232 Gly Cys Cys Gly Asn Xaa Ala Cys Ser Gly Ser Ser Xaa Asp Ala Xaa Ser Cys <210> 233 <211> 108 <212> DNA
<213> Conus imperialis <220>
<221> CDS
<222> (1)..(105) <400> 233 tct gat gga aag agt gcc gcg gcc aaa gcc aaa ccg tct cac ctg acg 48 Ser Asp Gly Lys Ser Ala Ala Ala Lys Ala Lys Pro Ser His Leu Thr get cca ttc atc agg gac gaa tgc tgt tcc gat tct cgc tgt ggc aag 96 Ala Pro Phe Ile Arg Asp Glu Cys Cys Ser Asp Ser Arg Cys Gly Lys aac tgt ctt tga 108 Asn Cys Leu <210> 234 <211> 35 <212> PRT
<213> Conus imperialis <400> 234 Ser Asp Gly Lys Ser Ala Ala Ala Lys Ala Lys Pro Ser His Leu Thr Ala Pro Phe Ile Arg Asp G:1.u Cys Cys Ser Asp Ser Arg Cys Gly Lys Asn Cys Leu <210> 235 <211> 108 <212> DNA
<213> Conus imperialis <220>
<221> CDS
<222> (1)..(105) <400> 235 ttt gat gga agg aat gcc cca gcc gac gac aaa gcg tct gac ctg atc 48 Phe Asp Gly Arg Asn Ala Pro Ala Asp Asp Lys Ala Ser Asp Leu Ile get caa atc gtc agg aga gca tgc tgt tcc gat cgt cgc tgt aga tgg 96 Ala Gin Ile Val Arg Arg Ala Cys Cys Ser Asp Arg Arg Cys Arg Trp agg tgt ggt tga 108 Arg Cys Gly <210> 236 <211> 35 <212> PRT
<213> Conus imperialis <400> 236 Phe Asp Gly Arg Asn Ala Pro Ala Asp Asp Lys Ala Ser Asp Leu Ile Ala Gln Ile Val Arg Arg A'-a Cys Cys Ser Asp Arg Arg Cys Arg Trp Arg Cys Gly <210> 237 <211> 145 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(105) <400> 237 tct gat gga agg aat gcc gca gcc gac gcc aga gcg tct ccc cgg atc 48 Ser Asp Gly Arg Asn Ala Ala Ala Asp Ala Arg Ala Ser Pro Arg Ile get ctt ttc ctc agg ttc arc tgc tgt agg aga ggt acc tgt tcc cag 96 Ala Leu Phe Leu Arg Phe Thr Cys Cys Arg Arg Gly Thr Cys Ser Gln cac tgt ggt tgaagacact gct:gctccag gaccctctga accacgacgt 145 His Cys Gly <210> 238 <211> 35 <212> PRT
<213> Conus regius <400> 238 Ser Asp Gly Arg Asn Ala A- - Ala Asp Ala Arg Ala Ser Pro Arg Ile Ala Leu Phe Leu Arg Phe Thr Cys Cys Arg Arg Gly Thr Cys Ser Gln His Cys Gly <210> 239 <211> 145 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(105) <400> 239 tct aat gga agg aat gcc gca gcc gac gcc aaa gcg tct caa cgg atc 48 Ser Asn Gly Arg Asn Ala Ala Ala Asp Ala Lys Ala Ser Gln Arg Ile get cca ttc ctc agg gac tat tgc tgt agg aga cat gcc tgt acg ttg 96 Ala Pro Phe Leu Arg Asp Tyr Cys Cys Arg Arg His Ala Cys Thr Leu att tgt ggt tgaagacgct gctgctccag gaccctctga accacgacgt 145 Ile Cys Gly <210> 240 <211> 35 <212> PRT
<213> Conus regius <400> 240 Ser Asn Gly Arg Asn Ala Ala Ala Asp Ala Lys Ala Ser Gln Arg Ile Ala Pro Phe Leu Arg Asp Tyr Cys Cys Arg Arg His Ala Cys Thr Leu Ile Cys Gly <210> 241 <211> 145 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(105) <400> 241 tct aat gga agg aat gcc gca gcc gac gcc aaa gcg tct caa cgg atc 48 Ser Asn Gly Arg Asn Ala Ala Ala Asp Ala Lys Ala Ser Gln Arg Ile get cca ttc ctc agg gac tat tgc tgt agg aga cct ccc tgt acg ttg 96 Ala Pro Phe Leu Arg Asp Tyr Cys Cys Arg Arg Pro Pro Cys Thr Leu att tgt ggt tgaagacgct gctgctccag gaccctctga accacgacgt 145 Ile Cys Gly <210> 242 <211> 35 <212> PRT
<213> Conus regius <400> 242 Ser Asn Gly Arg Asn Ala Ala Ala Asp Ala Lys Ala Ser Gln Arg Ile Ala Pro Phe Leu Arg Asp Tyr Cys Cys Arg Arg Pro Pro Cys Thr Leu Ile Cys Gly <210> 243 <211> 136 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(96) <400> 243 tct aat aaa agg aag aat gcc gca atg ctt gac atg atc get caa cac 48 Ser Asn Lys Arg Lys Asn Ala Ala Met Leu Asp Met Ile Ala Gln His gcc ata agg ggt tgc tgt tcc gat cct cgc tgt aga tat aga tgt cgt 96 Ala Ile Arg Gly Cys Cys Ser Asp Pro Arg Cys Arg Tyr Arg Cys Arg tgaagacgct gctgctccag gaccctctga accacgacgt 136 <210> 244 <211> 32 <212> PRT
<213> Conus regius <400> 244 Ser Asn Lys Arg Lys Asn Ala Ala Met Leu Asp Met Ile Ala Gln His Ala Ile Arg Gly Cys Cys Ser Asp Pro Arg Cys Arg Tyr Arg Cys Arg <210> 245 <211> 145 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(105) <400> 245 ttt aat gga agg agt gcc gca gcc gac caa aat gcg cct ggc ctg atc 48 Phe Asn Gly Arg Ser Ala Ala Ala Asp Gln Asn Ala Pro Gly Leu Ile get caa gtc gtc aga gga ggg tgc tgt tcc gat ccc cgc tgc gcc tgg 96 Ala Gln Val Val Arg Gly Gly Cys Cys Ser Asp Pro Arg Cys Ala Trp aga tgt ggt tgaagacgtt gct:gctccag gaccctctga accacgacgt 145 Arg Cys Gly <210> 246 <211> 35 <212> PRT
<213> Conus regius <400> 246 Phe Asn Gly Arg Ser Ala Ala Ala Asp Gln Asn Ala Pro Gly Leu Ile Ala Gln Val Val Arg Gly Gay Cys Cys Ser Asp Pro Arg Cys Ala Trp Arg Cys Gly <210> 247 <211> 145 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(105) <400> 247 ttt gat gga agg aat gcc gca gcc gac gcc aaa gtg att aac acg gtc 48 Phe Asp Gly Arg Asn Ala Ala Ala Asp Ala Lys Val Ile Asn Thr Val get cga atc gcc tgg gat ata tgc tgt tcc gaa cct gac tgt aac cat 96 Ala Arg Ile Ala Trp Asp Ile Cys Cys Ser Glu Pro Asp Cys Asn His aaa tgt gtt tgaagacgct tctgctccag gaccctctga accacgacgt 145 Lys Cys Val <210> 248 <211> 35 <212> PRT
<213> Conus regius <400> 248 Phe Asp Gly Arg Asn Ala Ala Ala Asp Ala Lys Val Ile Asn Thr Val Ala Arg Ile Ala Trp Asp Ile Cys Cys Ser Glu Pro Asp Cys Asn His Lys Cys Val <210> 249 <211> 136 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(96) <400> 249 tct aat aaa agg aag aat gcc gca atg ctt gac atg atc get caa cac 48 Ser Asn Lys Arg Lys Asn Ala. Ala Met Leu Asp Met Ile Ala Gln His gcc ata agg ggt tgc tgt tcc gat cct cgc tgt aaa cat cag tgt ggt 96 Ala Ile Arg Gly Cys Cys Ser Asp Pro Arg Cys Lys His Gln Cys Gly tgaagacgct gctgctccag gaccctctga accacgacgt 136 <210> 250 <211> 32 <212> PRT
<213> Conus regius <400> 250 Ser Asn Lys Arg Lys Asn Ala Ala Met Leu Asp Met Ile Ala Gln His Ala Ile Arg Gly Cys Cys Ser Asp Pro Arg Cys Lys His Gln Cys Gly <210> 251 <211> 136 <212> DNA
<213> Conus musicus <220>
<221> CDS
<222> (1)..(105) <400> 251 atc aag aat aca gca gcc aqc aac aaa gcg tct agc ctg gtg get ctt 48 Ile Lys Asn Thr Ala Ala Ser Asn Lys Ala Ser Ser Leu Val Ala Leu gtt gtc agg gga tgc tgt tac aat cct gtc tgc aag aaa tat tat tgt 96 Val Val Arg Gly Cys Cys Tyr Asn Pro Val Cys Lys Lys Tyr Tyr Cys tgg aaa ggc tgatgctcca ggaccctctg aaccacgacg t 136 Trp Lys Gly <210> 252 <211> 35 <212> PRT
<213> Conus musicus <400> 252 Ile Lys Asn Thr Ala Ala Ser Asn Lys Ala Ser Ser Leu Val Ala Leu Val Val Arg Gly Cys Cys Tyr Asn Pro Val Cys Lys Lys Tyr Tyr Cys Trp Lys Gly <210> 253 <211> 148 <212> DNA
<213> Conus purpurascens <220>
<221> CDS
<222> (1)..(117) <400> 253 tct gaa ggc agg aat get gaa gcc atc gac aac gcc tta gac cag agg 48 Ser Glu Gly Arg Asn Ala G:Lu Ala Ile Asp Asn Ala Leu Asp Gln Arg gat cca aag cga cag gag ccg ggg tgc tgt agg cat cct gcc tgt ggg 96 Asp Pro Lys Arg Gln Glu Pro Gly Cys Cys Arg His Pro Ala Cys Gly aag aac aga tgt gga aga cgc tgatgctcca ggaccctctg aaccacgacg t 148 Lys Asn Arg Cys Gly Arg Arg <210> 254 <211> 39 <212> PRT
<213> Conus purpurascens <400> 254 Ser Glu Gly Arg Asn Ala Glu Ala Ile Asp Asn Ala Leu Asp Gln Arg Asp Pro Lys Arg Gln Glu Pro Giy Cys Cys Arg His Pro Ala Cys Gly Lys Asn Arg Cys Gly Arg Arg <210> 255 <211> 156 <212> DNA
<213> Conus musicus <220>
<221> CDS
<222> (1)..(102) <400> 255 tct gat ggc agg aat att gca gtc gac gac aga tgg tct ttc tat acg 48 Ser Asp Gly Arg Asn Ile Ala Val Asp Asp Arg Trp Ser Phe Tyr Thr ctc ttc cat get act tgc tgt gcc gat cct gac tgt aga ttc cgg ccc 96 Leu Phe His Ala Thr Cys Cys Ala Asp Pro Asp Cys Arg Phe Arg Pro ggt tgt tgatctttgt tcttcaaaga cgctgctggc ccaggaccct ctgaaccacg 152 Gly Cys acgt 156 <210> 256 <211> 34 <212> PRT
<213> Conus musicus <400> 256 Ser Asp Gly Arg Asn Ile Ala Val Asp Asp Arg Trp Ser Phe Tyr Thr Leu Phe His Ala Thr Cys Cys Ala Asp Pro Asp Cys Arg Phe Arg Pro Gly Cys <210> 257 <211> 142 <212> DNA
<213> Conus musicus <220>
<221> CDS
<222> (1) .. (102) <400> 257 atc aag aat act gca gcc agc aac aaa gcg cct agc ctg gtg get att 48 Ile Lys Asn Thr Ala Ala Ser Asn Lys Ala Pro Ser Leu Val Ala Ile gcc gtc agg gga tgc tgt tac aat cct tcc tgt tgg ccg aaa aca tat 96 Ala Val Arg Gly Cys Cys Tyr Asn Pro Ser Cys Trp Pro Lys Thr Tyr tgt agt tggaaaggct gatgctccag gaccctctga accacgacgt 142 Cys Ser <210> 258 <211> 34 <212> PRT
<213> Conus musicus <400> 258 Ile Lys Asn Thr Ala Ala Ser Asn Lys Ala Pro Ser Leu Val Ala Ile Ala Val Arg Gly Cys Cys Tyr Asn Pro Ser Cys Trp Pro Lys Thr Tyr Cys Ser <210> 259 <211> 161 <212> DNA

<213> Conus musicus <220>
<221> CDS
<222> (1)..(108) <400> 259 tct gat agc agg aat gtc gca atc gag gac aga gtg tct gac ctg cac 48 Ser Asp Ser Arg Asn Val Ala Ile Glu Asp Arg Val Ser Asp Leu His tct atg ttc ttc gat gtt tot tgc tgt agc aat cct acc tgt aaa gaa 96 Ser Met Phe Phe Asp Val Seer Cys Cys Ser Asn Pro Thr Cys Lys Glu acg tat ggt tgt tgatcgttgq ttttgaagac gctgatgctc caggaccctc 148 Thr Tyr Gly Cys tgaaccacga cgt 161 <210> 260 <211> 36 <212> PRT
<213> Conus musicus <400> 260 Ser Asp Ser Arg Asn Val A.1.a Ile Glu Asp Arg Val Ser Asp Leu His Ser Met Phe Phe Asp Val Ser Cys Cys Ser Asn Pro Thr Cys Lys Glu Thr Tyr Gly Cys <210> 261 <211> 156 <212> DNA
<213> Conus musicus <220>
<221> CDS
<222> (1)..(102) <400> 261 tct gtt ggc agg aat att gca gtc gac gac aga ggg att ttc tct acg 48 Ser Val Gly Arg Asn Ile Ala Val Asp Asp Arg Gly Ile Phe Ser Thr ctc ttc cat get cat tgc tgt gcc aat ccc atc tgt aaa aac acg ccc 96 Leu Phe His Ala His Cys Cys Ala Asn Pro Ile Cys Lys Asn Thr Pro ggt tgt tgatctttgt tcttcaaaga cgctgctggc ccaggaccct ctgaaccacg 152 Gly Cys acgt 156 <210> 262 <211> 34 <212> PRT
<213> Conus musicus <400> 262 Ser Val Gly Arg Asn Ile Ala Val Asp Asp Arg Gly Ile Phe Ser Thr Leu Phe His Ala His Cys Cys Ala Asn Pro Ile Cys Lys Asn Thr Pro Gly Cys <210> 263 <211> 161 <212> DNA
<213> Conus musicus <220>
<221> CDS
<222> (1)..(108) <400> 263 tcc gat ggc agg aat gtc gca atc gac gac aga gtg tct gac ctg cac 48 Ser Asp Gly Arg Asn Val Ala Ile Asp Asp Arg Val Ser Asp Leu His tct atg ttc ttc gat att get tgc tgt aac aat cct acc tgt aaa gaa 96 Ser Met Phe Phe Asp Ile Ala Cys Cys Asn Asn Pro Thr Cys Lys Glu acg tat ggt tgt tgatcgttgg ttttgaagac gctgatgctc caggaccctc 148 Thr Tyr Gly Cys tgaaccacga cgt 161 <210> 264 <211> 36 <212> PRT
<213> Conus musicus <400> 264 Ser Asp Gly Arg Asn Val Ala Ile Asp Asp Arg Val Ser Asp Leu His Ser Met Phe Phe Asp Ile Ala Cys Cys Asn Asn Pro Thr Cys Lys Glu Thr Tyr Gly Cys <210> 265 <211> 161 <212> DNA
<213> Conus musicus <220>
<221> CDS
<222> (1)..(108) <400> 265 tct gat ggc agg aat gtc gca atc gag gac aga gtg tct gac ctg ctc 48 Ser Asp Gly Arg Asn Val Ala Ile Glu Asp Arg Val Ser Asp Leu Leu 1 5 1,0 15 tct atg ctc ttc gat gtt get tgc tgt agc aat cct gtc tgt aaa gaa 96 Ser Met Leu Phe Asp Val Ala Cys Cys Ser Asn Pro Val Cys Lys Glu acg tat ggt tgt tgatcgttgg ttttgaagac gctgatgctc caggaccctc 148 Thr Tyr Gly Cys tgaaccacga cgt 161 <210> 266 <211> 36 <212> PRT
<213> Conus musicus <400> 266 Ser Asp Gly Arg Asn Val Ala Ile Glu Asp Arg Val Ser Asp Leu Leu 1 5 1() 15 Ser Met Leu Phe Asp Val Ala Cys Cys Ser Asn Pro Val Cys Lys Glu Thr Tyr Gly Cys <210> 267 <211> 154 <212> DNA
<213> Conus betulinus <220>
<221> CDS

<222> (1)..(123) <400> 267 tat gat ggc agg aat get gcc gcc gac gac aaa get ttt gac ctg ctg 48 Tyr Asp Gly Arg Asn Ala Ala Ala Asp Asp Lys Ala Phe Asp Leu Leu get atg acc ata agg gga gga tgc tgt tcc tat cct ccc tgt atc gcg 96 Ala Met Thr Ile Arg Gly Gly Cys Cys Ser Tyr Pro Pro Cys Ile Ala agt aat cct aaa tgt ggt gga aga cgc tgatgctcca ggaccctctg 143 Ser Asn Pro Lys Cys Gly Gly Arg Arg aaccacaacg t 154 <210> 268 <211> 41 <212> PRT
<213> Conus betulinus <400> 268 Tyr Asp Gly Arg Asn Ala Ala Ala Asp Asp Lys Ala Phe Asp Leu Leu Ala Met Thr Ile Arg Gly Gly Cys Cys Ser Tyr Pro Pro Cys Ile Ala Ser Asn Pro Lys Cys Gly G:ly Arg Arg <210> 269 <211> 151 <212> DNA
<213> Conus lividus <220>
<221> CDS
<222> (1)..(111) <400> 269 ttt gat ggc agg aat get gc.a ggc aac gcc aaa atg tcc gcc ctg atg 48 Phe Asp Gly Arg Asn Ala Ala Gly Asn Ala Lys Met Ser Ala Leu Met gcc ctg acc atc agg gga tgc tgt tcc cat cct gtc tgt agc gcg atg 96 Ala Leu Thr Ile Arg Gly Cys Cys Ser His Pro Val Cys Ser Ala Met agt cca atc tgt ggc tgaagacgct gatgccccag gaccctctga accacgacgt 151 Ser Pro Ile Cys Gly <210> 270 <211> 37 <212> PRT
<213> Conus lividus <400> 270 Phe Asp Gly Arg Asn Ala Ala Gly Asn Ala Lys Met Ser Ala Leu Met Ala Leu Thr Ile Arg Gly Cys Cys Ser His Pro Val Cys Ser Ala Met Ser Pro Ile Cys Gly <210> 271 <211> 196 <212> DNA
<213> Conus musicus <220>
<221> CDS
<222> (1)..(165) <400> 271 atc aag aat get gca get gac gac aaa gca tct gac ctg ctc tct cag 48 Ile Lys Asn Ala Ala Ala Asp Asp Lys Ala Ser Asp Leu Leu Ser Gln atc gtc agg aat get gca tcc aat gac aaa ggg tct gac ctg atg act 96 Ile Val Arg Asn Ala Ala Ser Asn Asp Lys Gly Ser Asp Leu Met Thr ctt gcc ctc agg gga tgc tgt aaa aat cct tac tgt ggt gcg tcg aaa 144 Leu Ala Leu Arg Gly Cys Cys Lys Asn Pro Tyr Cys Gly Ala Ser Lys aca tat tgt ggt aga aga cgc tgatgctcca ggaccctctg aaccacgacg t 196 Thr Tyr Cys Gly Arg Arg Arg so (:;5 <210> 272 <211> 55 <212> PRT
<213> Conus musicus <400> 272 Ile Lys Asn Ala Ala Ala Asp Asp Lys Ala Ser Asp Leu Leu Ser Gln Ile Val Arg Asn Ala Ala Ser Asn Asp Lys Gly Ser Asp Leu Met Thr Leu Ala Leu Arg Gly Cys Cys Lys Asn Pro Tyr Cys Gly Ala Ser Lys Thr Tyr Cys Gly Arg Arg Arg 50 5`i <210> 273 <211> 139 <212> DNA
<213> Conus omaria <220>
<221> CDS
<222> (40)..(108) <400> 273 tctgatggca ggaatgccgc agcgtctgac ctgatggat ctg acc atc aag gga 54 Leu Thr Ile Lys Gly tgc tgt tct tat cct ccc tgt ttc gcg act aat cca gac tgt ggt cga 102 Cys Cys Ser Tyr Pro Pro Cys Phe Ala Thr Asn Pro Asp Cys Gly Arg cga cgc tgatgctcca ggaccct:ctg aaccacgacg t 139 Arg Arg <210> 274 <211> 23 <212> PRT
<213> Conus omaria <400> 274 Leu Thr Ile Lys Gly Cys Cys Ser Tyr Pro Pro Cys Phe Ala Thr Asn Pro Asp Cys Gly Arg Arg Arg <210> 275 <211> 126 <212> DNA
<213> Conus radiatus <220>
<221> CDS
<222> (1) .. (123) <400> 275 ttt gat ggc agg aat gcc gca gcc gac tac aaa ggg tct gaa ttg ctc 48 Phe Asp Gly Arg Asn Ala Ala Ala Asp Tyr Lys Gly Ser Glu Leu Leu get atg acc gtc agg gga gga tgc tgt tcc tat cct ccc tgt atc gca 96 Ala Met Thr Val Arg Gly G1y Cys Cys Ser Tyr Pro Pro Cys Ile Ala aat aat cct ctt tgt get gga aga cgc tga 126 Asn Asn Pro Leu Cys Ala Gly Arg Arg <210> 276 <211> 41 <212> PRT
<213> Conus radiatus <400> 276 Phe Asp Gly Arg Asn Ala Ala Ala Asp Tyr Lys Gly Ser Glu Leu Leu Ala Met Thr Val Arg Gly Gly Cys Cys Ser Tyr Pro Pro Cys Ile Ala Asn Asn Pro Leu Cys Ala Gly Arg Arg <210> 277 <211> 126 <212> DNA
<213> Conus radiatus <220>
<221> CDS
<222> (1)..(123) <400> 277 ttt gat ggc agg aat gcc gca gcc gac tac aaa ggg tct gaa ttg ctc 48 Phe Asp Gly Arg Asn Ala Ala Ala Asp Tyr Lys Gly Ser Glu Leu Leu get atg acc gtc agg gga gga tgc tgt tcc tat cct ccc tgt atc gca 96 Ala Met Thr Val Arg Gly Sly Cys Cys Ser Tyr Pro Pro Cys Ile Ala aat aat cct ttt tgt get gga aga cgc tga 126 Asn Asn Pro Phe Cys Ala Gly Arg Arg <210> 278 <211> 41 <212> PRT
<213> Conus radiatus <400> 278 Phe Asp Gly Arg Asn Ala Ala Ala Asp Tyr Lys Gly Ser Glu Leu Leu Ala Met Thr Val Arg Gly Gl.y Cys Cys Ser Tyr Pro Pro Cys Ile Ala Asn Asn Pro Phe Cys Ala Gly Arg Arg <210> 279 <211> 155 <212> DNA
<213> Conus virgo <220>
<221> CDS
<222> (1)..(114) <400> 279 tct tat gac agg tat gcc tcg ccc gtc gac aga gcg tct gcc ctg atc 48 Ser Tyr Asp Arg Tyr Ala Ser Pro Val Asp Arg Ala Ser Ala Leu Ile 1 5 1() 15 get cag gcc atc ctt cga gat tgc tgt tcc aat cct ccc tgt tcc caa 96 Ala Gln Ala Ile Leu Arg Asp Cys Cys Ser Asn Pro Pro Cys Ser Gln aat aat cca gac tgt atg taaagacgct gcttgctcca ggaccctctg 144 Asn Asn Pro Asp Cys Met aaccacgacg t 155 <210> 280 <211> 38 <212> PRT
<213> Conus virgo <400> 280 Ser Tyr Asp Arg Tyr Ala Ser Pro Val Asp Arg Ala Ser Ala Leu Ile Ala Gln Ala Ile Leu Arg Asp Cys Cys Ser Asn Pro Pro Cys Ser Gln Asn Asn Pro Asp Cys Met <210> 281 <211> 155 <212> DNA
<213> Conus virgo <220>
<221> CDS
<222> (1) (114) <400> 281 tct tat ggc agg tat gcc tca ccc gtc gac aga gcg tct gcc ctg atc 48 Ser Tyr Gly Arg Tyr Ala Ser Pro Val Asp Arg Ala Ser Ala Leu Ile get cag gcc atc ctt cga gat tgc tgc tcc aat cct cct tgt gcc cat 96 Ala Gln Ala Ile Leu Arg Asp Cys Cys Ser Asn Pro Pro Cys Ala His aat aat cca gac tgt cgt taaagacgct gcttgctcca ggaccctctg 144 Asn Asn Pro Asp Cys Arg aaccacgacg t 155 <210> 282 <211> 38 <212> PRT
<213> Conus virgo <400> 282 Ser Tyr Gly Arg Tyr Ala Ser Pro Val Asp Arg Ala Ser Ala Leu Ile Ala Gln Ala Ile Leu Arg Asp Cys Cys Ser Asn Pro Pro Cys Ala His Asn Asn Pro Asp Cys Arg <210> 283 <211> 126 <212> DNA
<213> Conus achatinus <220>
<221> CDS
<222> (1)..(123) <400> 283 tct gat ggc agg aat gcc gca gcc aac gac aaa gcg tct ggc atg agc 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Gly Met Ser gcg ctg gcc gtc aat gaa tgc tgt acc aac cct gtc tgt cac gcg gaa 96 Ala Leu Ala Val Asn Glu Cys Cys Thr Asn Pro Val Cys His Ala Glu cat caa gaa ctt tgt get aga aga cgc tga 126 His Gln Glu Leu Cys Ala Arg Arg Arg <210> 284 <211> 41 <212> PRT
<213> Conus achatinus <400> 284 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Gly Met Ser Ala Leu Ala Val Asn Glu Cys Cys Thr Asn Pro Val Cys His Ala Glu His Gln Glu Leu Cys Ala Arg Arg Arg <210> 285 <211> 126 <212> DNA
<213> Conus achatinus <220>
<221> CDS
<222> (1)..(123) <400> 285 tct gat ggc agg aat gcc gca gcc aac gac aaa gcg tct gac gtg atc 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Val Ile acg ctg gcc ctc aag gga tc{c tgt tcc aac cct gtc tgt cac ttg gag 96 Thr Leu Ala Leu Lys Gly Cys Cys Ser Asn Pro Val Cys His Leu Glu cat tca aac ctt tgt ggt aga aga cgc tga 126 His Ser Asn Leu Cys Gly Arg Arg Arg <210> 286 <211> 41 <212> PRT
<213> Conus achatinus <400> 286 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Val Ile Thr Leu Ala Leu Lys Gly Cys Cys Ser Asn Pro Val Cys His Leu Glu His Ser Asn Leu Cys Gly Arg Arg Arg <210> 287 <211> 126 <212> DNA
<213> Conus achatinus <220>
<221> CDS
<222> (1)..(123) <400> 287 tct gat ggc agg aat gcc gca gcc aac gac aaa gcg tct ggc atg agc 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Gly Met Ser gcg ctg gcc gtc aat gaa tqc. tgt acc aac cct gtc tgt cac gtg gaa 96 Ala Leu Ala Val Asn Glu Cys Cys Thr Asn Pro Val Cys His Val Glu cat caa gaa ctt tgt get aga aga cgc tga 126 His Gln Glu Leu Cys Ala Arg Arg Arg <210> 288 <211> 41 <212> PRT
<213> Conus achatinus <400> 288 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Gly Met Ser Ala Leu Ala Val Asn Glu Cys Cys Thr Asn Pro Val Cys His Val Glu His Gln Glu Leu Cys Ala Arg Arg Arg <210> 289 <211> 220 <212> DNA
<213> Conus ammiralis <220>
<221> CDS
<222> (1)..(180) <400> 289 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Lou Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca ttt cgt ggc agg aat gcc gca gcc aaa gcg 96 Phe Thr Ser Asp Arg Ala Phe Arg Gly Arg Asn Ala Ala Ala Lys Ala tct ggc ctg gtc ggt ctg acc gac aag agg caa gaa tgc tgt tct tat 144 Ser Gly Leu Val Gly Leu Thr Asp Lys Arg Gln Glu Cys Cys Ser Tyr cct gcc tgt aac cta gat cat cca gaa ctt tgt ggt tgaagacgct 190 Pro Ala Cys Asn Leu Asp His Pro Glu Leu Cys Gly gatgctccag gaccctctga accacgacgt 220 <210> 290 <211> 60 <212> PRT
<213> Conus ammiralis <400> 290 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Arg Ala Phe Arg Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Gly Leu Thr Asp Lys Arg Gln Glu Cys Cys Ser Tyr Pro Ala Cys Asn Leu Asp His Pro Glu Leu Cys Gly <210> 291 <211> 223 <212> DNA
<213> Conus ammiralis <220>
<221> CDS
<222> (1)..(192) <400> 291 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc act gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser tcc act tca ggt cgt cgt gca ttt cgt ggc agg aat gcc gca gcc aaa 96 Ser Thr Ser Gly Arg Arg Ala Phe Arg Gly Arg Asn Ala Ala Ala Lys gcg tct gga ctg gtc ggt ctg act gac agg aga cca gaa tgc tgt agt 144 Ala Ser Gly Leu Val Gly Leu Thr Asp Arg Arg Pro Glu Cys Cys Ser gat cct cgc tgt aac tcg act cat cca gaa ctt tgt ggt gga aga cgc 192 Asp Pro Arg Cys Asn Ser Thr. His Pro Glu Leu Cys Gly Gly Arg Arg tgatgctcca ggaccctctg aaccacgacg t 223 <210> 292 <211> 64 <212> PRT
<213> Conus ammiralis <400> 292 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Ser Thr Ser Gly Arg Arg A:La Phe Arg Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Gly Leu Thr Asp Arg Arg Pro Glu Cys Cys Ser Asp Pro Arg Cys Asn Ser Thr His Pro Glu Leu Cys Gly Gly Arg Arg <210> 293 <211> 151 <212> DNA
<213> Conus arenatus <220>
<221> CDS
<222> (1)..(120) <400> 293 tct gat ggc agg aat gcc gca gcc aac gcg ttt gac ctg atc gat ctg 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Phe Asp Leu Ile Asp Leu acc gcc agg cta aat tgc tgt atg att ccc ccc tgt tgg aag aaa tat 96 Thr Ala Arg Leu Asn Cys Cys Met Ile Pro Pro Cys Trp Lys Lys Tyr gga gac aga tgt agt gaa gta cgc tgatgctcca ggaccctctg aaccacgacg 150 Gly Asp Arg Cys Ser Glu Val Arg t 151 <210> 294 <211> 40 <212> PRT
<213> Conus arenatus <400> 294 Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Phe Asp Leu Ile Asp Leu Thr Ala Arg Leu Asn Cys Cys Met Ile Pro Pro Cys Trp Lys Lys Tyr Gly Asp Arg Cys Ser Glu Val Arg <210> 295 <211> 126 <212> DNA
<213> Conus arenatus <220>
<221> CDS
<222> (1)..(93) <400> 295 tct gat ggc agg aat gcc gca cgc aaa gcg ttt ggc tgc tgc gac tta 48 Ser Asp Gly Arg Asn Ala Ala Arg Lys Ala Phe Gly Cys Cys Asp Leu ata ccc tgt ttg gag aga tat ggt aac aga tgt aat gaa gtg cac 93 Ile Pro Cys Leu Glu Arg Tyr Gly Asn Arg Cys Asn Glu Val His tgatgctcca ggaccctctg aaccacgcga cgt 126 <210> 296 <211> 31 <212> PRT
<213> Conus arenatus <400> 296 Ser Asp Gly Arg Asn Ala Ala Arg Lys Ala Phe Gly Cys Cys Asp Leu Ile Pro Cys Leu Glu Arg Tyr Gly Asn Arg Cys Asn Glu Val His <210> 297 <211> 151 <212> DNA
<213> Conus arenatus <220>
<221> CDS
<222> (1)..(120) <400> 297 tct gat ggc agc aat gcc gca gcc aac gag ttt gac ctg atc get ctg 48 Ser Asp Gly Ser Asn Ala Ala Ala Asn Glu Phe Asp Leu Ile Ala Leu acc gcc agg cta ggt tgc tgt aac gtt aca ccc tgt tgg gag aaa tat 96 Thr Ala Arg Leu Gly Cys Cys Asn Val Thr Pro Cys Trp Glu Lys Tyr gga gac aaa tgt aat gaa gta cgc tgatgcttca ggaccctctg aaccacgacg 150 Gly Asp Lys Cys Asn Glu Val Arg t 151 <210> 298 <211> 40 <212> PRT
<213> Conus arenatus <400> 298 Ser Asp Gly Ser Asn Ala Ala Ala Asn Glu Phe Asp Leu Ile Ala Leu Thr Ala Arg Leu Gly Cys Cys Asn Val Thr Pro Cys Trp Glu Lys Tyr Gly Asp Lys Cys Asn Glu Val Arg <210> 299 <211> 148 <212> DNA
<213> Conus arenatus <220>
<221> CDS
<222> (1)..(117) <400> 299 tct gat ggc agg aat gtc gca gca aaa gcg ttt cac cgg atc ggc cgg 48 Ser Asp Gly Arg Asn Val Ala Ala Lys Ala Phe His Arg Ile Gly Arg 1 5 1.0 15 acc atc agg gat gaa tgc tgt tcc aat cct gcc tgt agg gtg aat aat 96 Thr Ile Arg Asp Glu Cys Cys Ser Asn Pro A:La Cys Arg Val Asn Asn cca cac gtt tgt aga cga cgc tgatgctcca ggaccctctg aaccacgacg t 148 Pro His Val Cys Arg Arg Arg <210> 300 <211> 39 <212> PRT
<213> Conus arenatus <400> 300 Ser Asp Gly Arg Asn Val Ala Ala Lys Ala Phe His Arg Ile Gly Arg Thr Ile Arg Asp Glu Cys Cys Ser Asn Pro Ala Cys Arg Val Asn Asn Pro His Val Cys Arg Arg Arg <210> 301 <211> 151 <212> DNA
<213> Conus arenatus <220>
<221> CDS
<222> (1)..(120) <400> 301 tct gat ggc agg aat gcc gca gcc aac gcg ttt gac ctg atg cct ctg 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Phe Asp Leu Met Pro Leu acc gcc agg cta aat tgc tgt agc att ccc ggc tgt tgg aac gaa tat 96 Thr Ala Arg Leu Asn Cys Cys Ser Ile Pro Gly Cys Trp Asn Glu Tyr aaa gac aga tgt agt aaa gta cgc tgatgctcca ggaccctctg aaccacgacg 150 Lys Asp Arg Cys Ser Lys Val Arg t 151 <210> 302 <211> 40 <212> PRT
<213> Conus arenatus <400> 302 Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Phe Asp Leu Met Pro Leu Thr Ala Arg Leu Asn Cys Cys Ser Ile Pro Gly Cys Trp Asn Glu Tyr Lys Asp Arg Cys Ser Lys Val Arg <210> 303 <211> 157 <212> DNA
<213> Conus aurisiacus <220>
<221> CDS
<222> (52)..(126) <400> 303 tctgatggca ggaatgccgc agccgacgac aaagcgtctg acctggtcgc t ctg gtc 57 Leu Val gtc agg gga gga tgc tgt tcc cac cct gtc tgt tac ttt aat aat cca 105 Val Arg Gly Gly Cys Cys Ser His Pro Val Cys Tyr Phe Asn Asn Pro 10 1.5 caa atg tgt cgt gga aga cgc tgatgctcca ggaccctctg aaccacgacg t 157 Gin Met Cys Arg Gly Arg Arg <210> 304 <211> 25 <212> PRT
<213> Conus aurisiacus <400> 304 Leu Val Val Arg Gly Gly Cys Cys Ser His Pro Val Cys Tyr Phe Asn Asn Pro Gln Met Cys Arg Gly Arg Arg <210> 305 <211> 157 <212> DNA
<213> Conus aurisiacus <220>
<221> CDS
<222> (52)..(126) <400> 305 tctgatggca ggaatgccgc agccgacgac aaagcgtctg acctggtcgc t ctg gcc 57 Leu Ala gtc agg gga gga tgc tgt tcc cac cct gtc tgt aac ttg aat aat cca 105 Val Arg Gly Gly Cys Cys Ser His Pro Val Cys Asn Leu Asn Asn Pro caa atg tgt cgt gga aga cgc tgatgctcca ggaccctctg aaccacgacg t 157 Gln Met Cys Arg Gly Arg A.rg <210> 306 <211> 25 <212> PRT
<213> Conus aurisiacus <400> 306 Leu Ala Val Arg Gly Gly Cys Cys Ser His Pro Val Cys Asn Leu Asn Asn Pro Gln Met Cys Arg Gly Arg Arg <210> 307 <211> 157 <212> DNA
<213> Conus betulinus <220>
<221> CDS
<222> (1)..(117) <400> 307 ttt cgt ggc agg aat ccc gca gcc aac gac aaa agg tct gac ctg gcc 48 Phe Arg Gly Arg Asn Pro Ala Ala Asn Asp Lys Arg Ser Asp Leu Ala get ctg agc gtc agg gga gga tgc tgt tcc cat cct gcc tgt agc gtg 96 Ala Leu Ser Val Arg Gly Gly Cys Cys Ser His Pro Ala Cys Ser Val act cat cca gag ctt tgt ggc tgaagacgct gatgccccag gaccctctga 147 Thr His Pro Glu Leu Cys Gly accacgacgt 157 <210> 308 <211> 39 <212> PRT
<213> Conus betulinus <400> 308 Phe Arg Gly Arg Asn Pro Ala Ala Asn Asp Lys Arg Ser Asp Leu Ala 1 5 1.0 15 Ala Leu Ser Val Arg Gly Gly Cys Cys Ser His Pro Ala Cys Ser Val Thr His Pro Glu Leu Cys Gly 1,28 <210> 309 <211> 151 <212> DNA
<213> Conus betulinus <220>
<221> CDS
<222> (1)..(120) <400> 309 tct gat ggc ggg aat gcc gca gcc aaa gcg tct gac ctg atc get cag 48 Ser Asp Gly Gly Asn Ala Ala Ala Lys Ala Ser Asp Leu Ile Ala Gln acc atc agg gga gga tgc tgt tcc tat cct gcc tgt agc gtg gaa cat 96 Thr Ile Arg Gly Gly Cys Cys Ser Tyr Pro Ala Cys Ser Val Glu His caa gac ctt tgt gat gga aga cgc tgatgctcca ggaccctctg aaccacgacg 150 Gln Asp Leu Cys Asp Gly Arg Arg t 151 <210> 310 <211> 40 <212> PRT
<213> Conus betulinus <400> 310 Ser Asp Gly Gly Asn Ala Ala Ala Lys Ala Ser Asp Leu Ile Ala Gln Thr Ile Arg Gly Gly Cys Cys Ser Tyr Pro Ala Cys Ser Val Glu His Gln Asp Leu Cys Asp Gly Arg Arg <210> 311 <211> 114 <212> DNA
<213> Conus caracterist:i.cus <220>
<221> CDS
<222> (1)..(111) <400> 311 tct tat ggc agg aat gcc gca gcc aaa gcg ttt gaa gtg agt tgc tgt 48 Ser Tyr Gly Arg Asn Ala Ala Ala Lys Ala Phe Glu Val Ser Cys Cys gtc gtt cgc ccc tgt tgg att cgc tat caa gag gaa tgt ctt gaa gca 96 Val Val Arg Pro Cys Trp Ile Arg Tyr Gln Glu Glu Cys Leu Glu Ala gat ccc agg acc ctc tga 114 Asp Pro Arg Thr Leu <210> 312 <211> 37 <212> PRT
<213> Conus caracteristicus <400> 312 Ser Tyr Gly Arg Asn Ala Ala Ala Lys Ala Phe Glu Val Ser Cys Cys Val Val Arg Pro Cys Trp Ile Arg Tyr Gln Glu Glu Cys Leu Glu Ala Asp Pro Arg Thr Leu <210> 313 <211> 123 <212> DNA
<213> Conus caracteristicus <220>
<221> CDS
<222> (1) .. (120) <400> 313 tct gat ggc agg aat gcc gca gcc aac gcc ct.t gac ctg atc act ctg 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Leu Asp Leu Ile Thr Leu 1 5 1 () 15 atc gcc agg caa aat tgc tgt agc att ccc ggc tgt tgg gag aaa tat 96 Ile Ala Arg Gln Asn Cys Cys Ser Ile Pro Gly Cys Trp Glu Lys Tyr gga gac aaa tgt agt gaa gta cgc tga 123 Gly Asp Lys Cys Ser Glu Val Arg <210> 314 <211> 40 <212> PRT
<213> Conus caracteristicus <400> 314 Ser Asp Gly Arg Asn Ala Ala Ala Asn Ala Leu Asp Leu Ile Thr Leu Ile Ala Arg Gln Asn Cys Cys Ser Ile Pro Gly Cys Trp Glu Lys Tyr Gly Asp Lys Cys Ser Glu Val Arg <210> 315 <211> 154 <212> DNA
<213> Conus catus <220>
<221> CDS
<222> (1)..(123) <400> 315 tct gat ggc agg aat gaa gca gcc aac gac gaa gcg tct gac gtg atc 48 Ser Asp Gly Arg Asn Glu Ala Ala Asn Asp Glu Ala Ser Asp Val Ile gag ctg gcc ctc aag gga tgc tgt tcc aac cct gtc tgt cac ttg gag 96 Glu Leu Ala Leu Lys Gly Cys Cys Ser Asn Pro Val Cys His Leu Glu cat cca aac get tgt ggt aqa aga cgc tgatgctcca ggaccctctg 143 His Pro Asn Ala Cys Gly Arg Arg Arg aaccacgacg t 154 <210> 316 <211> 41 <212> PRT
<213> Conus catus <400> 316 Ser Asp Gly Arg Asn Glu Ala Ala Asn Asp Glu Ala Ser Asp Val Ile Glu Leu Ala Leu Lys Gly Cys Cys Ser Asn Pro Val Cys His Leu Glu His Pro Asn Ala Cys Gly Arg Arg Arg <210> 317 <211> 154 <212> DNA
<213> Conus catus <220>
<221> CDS
<222> (1) (123) <400> 317 tct gat ggc agg aat gcc gca gcc aac gac aaa gcg tct gac ctg gtc 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Leu Val get ctg gcc gtc agg gga tgc tgt tcc aac cct atc tgt tac ttt aat 96 Ala Leu Ala Val Arg Gly Cys Cys Ser Asn Pro Ile Cys Tyr Phe Asn aat cca cga att tgt cgt gga aga cgc tgatgctcca ggaccctctg 143 Asn Pro Arg Ile Cys Arg Gly Arg Arg aaccacgacg t 154 <210> 318 <211> 41 <212> PRT
<213> Conus catus <400> 318 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Leu Val Ala Leu Ala Val Arg Gly Cys Cys Ser Asn Pro Ile Cys Tyr Phe Asn Asn Pro Arg Ile Cys Arg Gly Arg Arg <210> 319 <211> 111 <212> DNA
<213> Conus episcopatus <220>
<221> CDS
<222> (1)..(108) <400> 319 tct cat ggc agg aat gcc gca cgc aaa gcg tct gac ctg atc get ctg 48 Ser His Gly Arg Asn Ala Ala Arg Lys Ala Ser Asp Leu Ile Ala Leu acc gtc agg gaa tgc tgt tct cag cct ccc tgt cgc tgg aaa cat cca 96 Thr Val Arg Glu Cys Cys Ser Gln Pro Pro Cys Arg Trp Lys His Pro gaa ctt tgt agt tga ill Glu Leu Cys Ser <210> 320 <211> 36 <212> PRT
<213> Conus episcopatus <400> 320 Ser His Gly Arg Asn Ala Ala Arg Lys Ala Ser Asp Leu Ile Ala Leu Thr Val Arg Glu Cys Cys Ser Gln Pro Pro Cys Arg Trp Lys His Pro Glu Leu Cys Ser <210> 321 <211> 151 <212> DNA
<213> Conus geographus <220>
<221> CDS
<222> (1)..(120) <400> 321 tct gat ggc agg aat gac gca gcc aaa gcg ttt gac ctg ata tct tcg 48 Ser Asp Gly Arg Asn Asp Ala Ala Lys Ala Phe Asp Leu Ile Ser Ser acc gtc aag aaa gga tgc tgt tcc cat cct gcc tgt gcg ggg aat aat 96 Thr Val Lys Lys Gly Cys Cys Ser His Pro Ala Cys Ala Gly Asn Asn caa cat att tgt ggc cga aga cgc tgatgctcca ggaccctctg aaccacgacg 150 Gln His Ile Cys Gly Arg Arg Arg t 151 <210> 322 <211> 40 <212> PRT
<213> Conus geographus <400> 322 Ser Asp Gly Arg Asn Asp Ala Ala Lys Ala Phe Asp Leu Ile Ser Ser Thr Val Lys Lys Gly Cys Cys Ser His Pro Ala Cys Ala Gly Asn Asn Gln His Ile Cys Gly Arg Arg Arg <210> 323 <211> 154 <212> DNA
<213> Conus geographus <220>
<221> CDS
<222> (1)..(123) <400> 323 tct gat ggc agg aat gcc gca gcc aac gac caa gcg tct gac ctg atg 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Gln Ala Ser Asp Leu Met get gcg acc gtc agg gga tgc tgt gcc gtt cct tcc tgt cgc ctc cgt 96 Ala Ala Thr Val Arg Gly Cys Cys Ala Val Pro Ser Cys Arg Leu Arg aat cca gac ctt tgt ggt gga gga cgc tgatgctcca ggaccctctg 143 Asn Pro Asp Leu Cys Gly Gly Gly Arg aaccacgacg t 154 <210> 324 <211> 41 <212> PRT
<213> Conus geographus <400> 324 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Gln Ala Ser Asp Leu Met Ala Ala Thr Val Arg Gly Cys Cys Ala Val Pro Ser Cys Arg Leu Arg Asn Pro Asp Leu Cys Gly Gly Gly Arg <210> 325 <211> 120 <212> DNA
<213> Conus imperialis <220>
<221> CDS
<222> (1)..(117) <400> 325 ctt gat gaa agg aat gcc gca gcc gac gac aaa gcg tct gac ctg atc 48 Leu Asp Glu Arg Asn Ala Ala Ala Asp Asp Lys Ala Ser Asp Leu Ile get caa atc gtc agg aga gga tgc tgt tcc cat cct gcc tgt aac gtg 96 Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Ala Cys Asn Val aat aat cca cac att tgt ggt tga 120 Asn Asn Pro His Ile Cys Gly <210> 326 <211> 39 <212> PRT
<213> Conus imperialis <400> 326 Leu Asp Glu Arg Asn Ala Ala Ala Asp Asp Lys Ala Ser Asp Leu Ile Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Ala Cys Asn Val Asn Asn Pro His Ile Cys Gly <210> 327 <211> 142 <212> DNA
<213> Conus lividus <220>
<221> CDS
<222> (1)..(111) <400> 327 tct gat ggc agg aat act gca gcc aaa gtc aaa tat tct aag acg ccg 48 Ser Asp Gly Arg Asn Thr Ala Ala Lys Val Lys Tyr Ser Lys Thr Pro gag gaa tgc tgt ccc aat cct ccc tgt ttc gcg aca aat tcg gat att 96 Glu Glu Cys Cys Pro Asn Pro Pro Cys Phe Ala Thr Asn Ser Asp Ile tgt ggc gga aga cgc tgatgctcca ggaccctctg aaccacgacg t 142 Cys Gly Gly Arg Arg <210> 328 <211> 37 <212> PRT
<213> Conus lividus <400> 328 Ser Asp Gly Arg Asn Thr Ala Ala Lys Val Lys Tyr Ser Lys Thr Pro Glu Glu Cys Cys Pro Asn Pro Pro Cys Phe Ala Thr Asn Ser Asp Ile Cys Gly Gly Arg Arg <210> 329 <211> 157 <212> DNA
<213> Conus lividus <220>
<221> CDS
<222> (1)..(117) <400> 329 tct aat ggc agg aat gcc gca gcc aaa ttc aaa gcg cct gcc ctg atg 48 Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met aag cgg acc gtc agg gat gct tgc tgt tca gac cct cgc tgt tcc ggg 96 Lys Arg Thr Val Arg Asp Ala Cys Cys Ser Asp Pro Arg Cys Ser Gly aaa cat caa gac ctg tgt ggc tgaagacgct gat:gctccag gaccctctga 147 Lys His Gln Asp Leu Cys Gly accacgacgt 157 <210> 330 <211> 39 <212> PRT
<213> Conus lividus <400> 330 Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met Lys Arg Thr Val Arg Asp Ala Cys Cys Ser Asp Pro Arg Cys Ser Gly Lys His Gln Asp Leu Cys Gly <210> 331 <211> 157 <212> DNA
<213> Conus lividus <220>
<221> CDS
<222> (1)..(117) <400> 331 tct aat ggc agg aat gcc gca gcc aaa ttc aaa gcg cct gcc ctg atg 48 Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met gag ctg acc gtc agg gaa gat tgC tgt tca gac cct cgc tgt tcc gtg 96 Glu Leu Thr Val Arg Glu Asp Cys Cys Ser Asp Pro Arg Cys Ser Val gga cat caa gac ctg tgt ggc tgaagacgct gatgctccag gaccctctga 147 Gly His Gln Asp Leu Cys Gly accacgacgt 157 <210> 332 <211> 39 <212> PRT
<213> Conus lividus <400> 332 Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met Glu Leu Thr Val Arg Glu Asp Cys Cys Ser Asp Pro Arg Cys Ser Val Gly His Gln Asp Leu Cys Gly <210> 333 <211> 157 <212> DNA
<213> Conus lividus <220>
<221> CDS
<222> (1) .. (126) <400> 333 gca ttt gat ggc agg aat get gca gcc agc gac aaa gcg tcc gag ctg 48 Ala Phe Asp Gly Arg Asn Ala Ala Ala Ser Asp Lys Ala Ser Glu Leu atg get ctg gcc gtc agg gga tgc tgt tcc cat cct gcc tgt get ggg 96 Met Ala Leu Ala Val Arg Gly Cys Cys Ser His Pro Ala Cys Ala Gly agt aat gca cat atc tgt ggc aga aga cgc tgatgctcca ggaccctctg 146 Ser Asn Ala His Ile Cys Gly Arg Arg Arq_ aaccacgacg t 157 <210> 334 <211> 42 <212> PRT
<213> Conus lividus <400> 334 Ala Phe Asp Gly Arg Asn Ala. Ala Ala Ser Asp Lys Ala Ser Glu Leu Met Ala Leu Ala Val Arg Gly Cys Cys Ser His Pro Ala Cys Ala Gly Ser Asn Ala His Ile Cys Gly Arg Arg Arg <210> 335 <211> 157 <212> DNA
<213> Conus lividus <220>
<221> CDS
<222> (1)..(117) <400> 335 tct aat ggc agg aat gcc gca gcc aaa ttc aaa gcg cct gcc ctg atg 48 Ser Asn Gly Arg Asn Ala A:La Ala Lys Phe Lys Ala Pro Ala Leu Met aag ctg acc gtc agg gag gat tgc tgt tca gac cct cgc tgt tcc gtg 96 Lys Leu Thr Val Arg Glu Asp Cys Cys Ser Asp Pro Arg Cys Ser Val gga cat caa gac atg tgt ggc tgaagacgct gatgctccag gaccctctga 147 Gly His Gin Asp Met Cys Gly atcacgacgt 157 <210> 336 <211> 39 <212> PRT
<213> Conus lividus <400> 336 Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met Lys Leu Thr Val Arg Glu Asp Cys Cys Ser Asp Pro Arg Cys Ser Val Gly His Gln Asp Met Cys Giy <210> 337 <211> 154 <212> DNA
<213> Conus lividus <220>
<221> CDS
<222> (1) .. (114) <400> 337 ttt gaa tgc agg aat get gca ggc aac gac aaa gcg act gac ctg atg 48 Phe Glu Cys Arg Asn Ala Ala Gly Asn Asp Lys Ala Thr Asp Leu Met get ctg act gtc agg gga tgc tgt tcc cat cct gcc tgt get ggg aat 96 Ala Leu Thr Val Arg Gly Cys Cys Ser His Pro Ala Cys Ala Gly Asn aat cca cat atc tgc ggc tgaagacgct gatgctccag gaccctctga 144 Asn Pro His Ile Cys Gly accacgacgt 154 <210> 338 <211> 38 <212> PRT
<213> Conus lividus <400> 338 Phe Glu Cys Arg Asn Ala Ala Gly Asn Asp Lys Ala Thr Asp Leu Met Ala Leu Thr Val Arg Gly Cys Cys Ser His Pro Ala Cys Ala Gly Asn Asn Pro His Ile Cys Gly <210> 339 <211> 154 <212> DNA

<213> Conus lividus <220>
<221> CDS
<222> (1)..(114) <400> 339 ttt gat ggc agg aac gcc gca gcc aac aac aaa gcg act gat ctg atg 48 Phe Asp Gly Arg Asn Ala Ala Ala Asn Asn Lys Ala Thr Asp Leu Met get ctg act gtc aga gga tgc tgt ggc aat cct tca tgt agc atc cat 96 Ala Leu Thr Val Arg Gly Cys Cys Gly Asn Pro Ser Cys Ser Ile His att cct tac gtt tgt aat tagagacact gatgctccag gaccctctga 144 Ile Pro Tyr Val Cys Asn accacgacgt 154 <210> 340 <211> 38 <212> PRT
<213> Conus lividus <400> 340 Phe Asp Gly Arg Asn Ala Ala Ala Asn Asn Lys Ala Thr Asp Leu Met Ala Leu Thr Val Arg Gly Cys Cys Gly Asn Pro Ser Cys Ser Ile His Ile Pro Tyr Val Cys Asn <210> 341 <211> 157 <212> DNA
<213> Conus lividus <220>
<221> CDS
<222> (1)..(126) <400> 341 tct aat ggc agg aat gcc gca gcc aaa ttc aaa gcg cct gcc ctg atg 48 Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met aag cgg acc gac agc gaa gaa tgc tgt tta gac tct cgc tgt gcc ggg 96 Lys Arg Thr Asp Ser Glu Glu Cys Cys Leu Asp Ser Arg Cys Ala Gly caa cat caa gac ctg tgt ggc gga aga cgc tgatgctcca ggaccctctg 146 Gln His Gln Asp Leu Cys Gly Gly Arg Arg aaccacgacg t 157 <210> 342 <211> 42 <212> PRT
<213> Conus lividus <400> 342 Ser Asn Gly Arg Asn Ala Ala Ala Lys Phe Lys Ala Pro Ala Leu Met Lys Arg Thr Asp Ser Glu Glu Cys Cys Leu Asp Ser Arg Cys Ala Gly Gln His Gln Asp Leu Cys Gly Gly Arg Arg <210> 343 <211> 126 <212> DNA
<213> Conus marmoreus <220>
<221> CDS
<222> (1)..(123) <400> 343 tct at ggc agg aat gcc gca gcc aag gac aaa gcg tct gac ctg gtc 48 Ser Asp Gly Arg Asn Ala Ala Ala Lys Asp Lys Ala Ser Asp Leu Val get ctg acc gtc aag gga tcgc tgt tct aat cct ccc tgt tac gcg aat 96 Ala Leu Thr Val Lys Gly Cys Cys Ser Asn Pro Pro Cys Tyr Ala Asn aat caa gcc tat tgt aat gga aga cgc tga 126 Asn Gln Ala Tyr Cys Asn Gly Arg Arg <210> 344 <211> 41 <212> PRT
<213> Conus marmoreus <400> 344 Ser Asp Gly Arg Asn Ala Ala Ala Lys Asp Lys Ala Ser Asp Leu Val 1 5 1.0 15 14:1 Ala Leu Thr Val Lys Gly Cys Cys Ser Asn Pro Pro Cys Tyr Ala Asn Asn Gln Ala Tyr Cys Asn Sly Arg Arg <210> 345 <211> 117 <212> DNA
<213> Conus marmoreus <220>
<221> CDS
<222> (1)..(114) <400> 345 tct gat ggc agg aat gcc gca gcc aag gac aaa gcg tct gac ctg gtc 48 Ser Asp Gly Arg Asn Ala Ala Ala Lys Asp Ly's Ala Ser Asp Leu Val get ctg acc gtc aag gga tgc tgt t.ct cat cct gcc tgt agc gtg aat 96 Ala Leu Thr Val Lys Gly Cys Cys Set His Pro Ala Cys Ser Val Asn aat cca gac att tgt ggt tc{a 117 Asn Pro Asp Ile Cys Gly <210> 346 <211> 38 <212> PRT
<213> Conus marmoreus <400> 346 Ser Asp Gly Arg Asn Ala Ala Ala Lys Asp Lys Ala Ser Asp Leu Val Ala Leu Thr Val Lys Gly Cys Cys Ser His Pro Ala Cys Ser Val Asn Asn Pro Asp Ile Cys Gly <210> 347 <211> 145 <212> DNA
<213> Conus musicus <220>
<221> CDS
<222> (1)..(114) <400> 347 tct gat ggc agg aat get gca gcc aac aac aaa gtg get ttg acc atg 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asn Lys Val Ala Leu Thr Met agg gga aaa tgc tgt atc aat gat gcg tgt cgc tcg aaa cat cca cag 96 Arg Gly Lys Cys Cys Ile Asn Asp Ala Cys Arg Ser Lys His Pro Gln tac tgt tct gga aga cgc tgatattcca ggaccctctg aaccacgacg t 145 Tyr Cys Ser Gly Arg Arg <210> 348 <211> 38 <212> PRT
<213> Conus musicus <400> 348 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asn Lys Val Ala Leu Thr Met 1 5 1 () 15 Arg Gly Lys Cys Cys Ile Asn Asp Ala Cys Arg Ser Lys His Pro Gln Tyr Cys Ser Gly Arg Arg <210> 349 <211> 154 <212> DNA
<213> Conus musicus <220>
<221> CDS
<222> (1)..(123) <400> 349 tct gat ggc agg aat get gca gcc aac gac aaa gtg tct gac cag atg 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Val Ser Asp Gln Met get ctg gtt gtc agg gga tgc tgt tac aat att gcc tgt aga att aat 96 Ala Leu Val Val Arg Gly Cys Cys Tyr Asn Ile Ala Cys Arg Ile Asn aat cca cgg tac tgt cgt gga aaa cgc tgatgttcca ggaccctctg 143 Asn Pro Arg Tyr Cys Arg Gly Lys Arg aaccacgacg t 154 <210> 350 <211> 41 <212> PRT
<213> Conus musicus <400> 350 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Val Ser Asp Gln Met Ala Leu Val Val Arg Gly Cys Cys Tyr Asn Ile Ala Cys Arg Ile Asn Asn Pro Arg Tyr Cys Arg Gly Lys Arg <210> 351 <211> 154 <212> DNA
<213> Conus obscurus <220>
<221> CDS
<222> (52)..(123) <400> 351 tctgaaggca ggaatgccgc agccaacgac aaagcgtctg acctgatggc t ctg aac 57 Leu Asn gtc agg gga tgc tgt tcc cat cct gtc tgt cgc ttc aat tat cca aaa 105 Val Arg Gly Cys Cys Ser His Pro Val Cys Arg Phe Asn Tyr Pro Lys tat tgt ggt gga aga cgc tgatggtcca ggaccctctg aaccacgacg t 154 Tyr Cys Gly Gly Arg Arg <210> 352 <211> 24 <212> PRT
<213> Conus obscurus <400> 352 Leu Asn Val Arg Gly Cys Cys Ser His Pro Val Cys Arg Phe Asn Tyr Pro Lys Tyr Cys Gly Gly Arg Arg <210> 353 <211> 151 <212> DNA
<213> Conus obscurus 14:4 <220>
<221> CDS
<222> (46)..(111) <400> 353 tctgatggcg ggaatgccgc agcaaaagcg tttgatctaa tcact ctg gcc ctc agg 57 Leu Ala Leu Arg gat gaa tgc tgt gcc agt cct ccc tgt cgt ttg aat aat cca tac gta 105 Asp Glu Cys Cys Ala Ser Pro Pro Cys Arg Leu Asn Asn Pro Tyr Val tgt cat tgacgacgct gatgctccag gaccctctga accacgacgt 151 Cys His <210> 354 <211> 22 <212> PRT
<213> Conus obscurus <400> 354 Leu Ala Leu Arg Asp Glu Cys Cys Ala Ser Pro Pro Cys Arg Leu Asn Asn Pro Tyr Val Cys His <210> 355 <211> 217 <212> DNA
<213> Conus obscurus <220>
<221> CDS
<222> (1)..(186) <400> 355 atg ttc acc gtg ttt ctg tt:g gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leeu Val Val Leu Ala Thr Thr Val Val Ser ccc act tca gat cgt gca tot gat agg agg aat gcc gca gcc aaa gcg 96 Pro Thr Ser Asp Arg Ala Seer Asp Arg Arg Asn Ala Ala Ala Lys Ala ttt gac ctg aga tat tcg acc gcc aag aga gga tgc tgt tcc aat cct 144 Phe Asp Leu Arg Tyr Ser Thr. Ala Lys Arg Gly Cys Cys Ser Asn Pro gtc tgt tgg cag aat aat gca gaa tac tgt cgt gaa agt ggc 186 Val Cys Trp Gln Asn Asn Ala Glu Tyr Cys Arg Glu Ser Gly 5o 55 60 taatgctcca ggaccctctg aaccacgacg t 217 <210> 356 <211> 62 <212> PRT
<213> Conus obscurus <400> 356 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser Pro Thr Ser Asp Arg Ala Ser Asp Arg Arg Asn Ala Ala Ala Lys Ala Phe Asp Leu Arg Tyr Ser Thr Ala Lys Arg Gly Cys Cys Ser Asn Pro Val Cys Trp Gln Asn Asn Ala Glu Tyr Cys Arg Glu Ser Gly <210> 357 <211> 208 <212> DNA
<213> Conus obscurus <220>
<221> CDS
<222> (1)..(168) <400> 357 atg ttc acc gtg ttt ctg ttg gtt gtc ttg gca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Leu Val Val Leu Ala Thr Thr Val Val Ser ttc act tca gat cgt gca tct gat ggc ggg aat gtc gca gcg tct cac 96 Phe Thr Ser Asp Arg Ala Ser Asp Gly Gly Asn Val Ala Ala Ser His ctg atc get ctg acc atc aag gga tgc tgt tct cac cct ccc tgt gcc 144 Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser His Pro Pro Cys Ala cag aat aat caa gac tat tgt ggt tgacgacgct gatgctccag gaccctctga 198 Gin Asn Asn Gln Asp Tyr Cys Gly accacgacgt 208 <210> 358 <211> 56 <212> PRT
<213> Conus obscurus <400> 358 Met Phe Thr Val Phe Leu Letu Val Val Leu Ala Thr Thr Val Val Ser Phe Thr Ser Asp Arg Ala Sear Asp Gly Gly Asn Val Ala Ala Ser His Leu Ile Ala Leu Thr Ile Lys Gly Cys Cys Ser His Pro Pro Cys Ala Gln Asn Asn Gln Asp Tyr Cys Gly <210> 359 <211> 217 <212> DNA
<213> Conus obscurus <220>
<221> CDS
<222> (1)..(186) <400> 359 atg ttc acc gtg ttt ctg tt:g gtt gtc tta tca acc acc gtc gtt tcc 48 Met Phe Thr Val Phe Leu Levu Val Val Leu Ser Thr Thr Val Val Ser tcc act tca gat cgt gca tct gat agg agg aat gcc gca gcc aaa gcg 96 Ser Thr Ser Asp Arg Ala Se>.r. Asp Arg Arg Asn Ala Ala Ala Lys Ala tct gac ctg atg tat tcg acc gtc aag aaa gga tgt tgt tcc cat cct 144 Ser Asp Leu Met Tyr Ser Thr Val Lys Lys Gly Cys Cys Ser His Pro gcc tgt tcg ggg aat aat cqa gaa tat tgt cgt gaa agt ggc 186 Ala Cys Ser Gly Asn Asn Arg Glu Tyr Cys Arg Glu Ser Gly taatgctcca ggaccctctg aaccacgacg t 217 <210> 360 <211> 62 <212> PRT
<213> Conus obscurus <400> 360 Met Phe Thr Val Phe Leu Leu Val Val Leu Ser Thr Thr Val Val Ser Ser Thr Ser Asp Arg Ala Soar Asp Arg Arg Asn Ala Ala Ala Lys Ala Ser Asp Leu Met Tyr Ser Thr Val Lys Lys Gly Cys Cys Ser His Pro Ala Cys Ser Gly Asn Asn Arg Glu Tyr Cys Arg Glu Ser Gly <210> 361 <211> 157 <212> DNA
<213> Conus omaria <220>
<221> CDS
<222> (52)..(126) <400> 361 tttgatggca ggaatgcctc agccgacagc aaagtggctg cccggatcgc t cag atc 57 Gln Ile gac agg gat cca tgc tgt tcc tat cct gac tgt ggc gcg aat cat cca 105 Asp Arg Asp Pro Cys Cys Ser Tyr Pro Asp Cys Gly Ala Asn His Pro 10 1.5 gag att tgt ggt gga aaa cclc tgatgctcca ggaccctctg aaccacgacg t 157 Glu Ile Cys Gly Gly Lys Arg <210> 362 <211> 25 <212> PRT
<213> Conus omaria <400> 362 Gln Ile Asp Arg Asp Pro Cys Cys Ser Tyr Pro Asp Cys Gly Ala Asn His Pro Glu Ile Cys Gly Gly Lys Arg <210> 363 <211> 128 <212> DNA
<213> Conus omaria <220>
<221> CDS
<222> (26) .. (88) <400> 363 tctcatggca ggaatgccgc acgct ctg acc gtc agg gaa tgc tgt tct cag 52 Leu Thr Val Arg Glu Cys Cys Ser Gln cct cct tgt cgc tgg aaa cat cca gaa ctt tgt agt tgaagacgct 98 Pro Pro Cys Arg Trp Lys His Pro Glu Leu Cys Ser gatgctccag gaccctctga accacgacgt 128 <210> 364 <211> 21 <212> PRT
<213> Conus omaria <400> 364 Leu Thr Val Arg Glu Cys Cys Ser Gln Pro Pro Cys Arg Trp Lys His Pro Glu Leu Cys Ser <210> 365 <211> 154 <212> DNA
<213> Conus omaria <220>
<221> CDS
<222> (52)..(123) <400> 365 tttgatggca ggaatgctgc agccagcgac aaagcgtctg agctgatggc t ctg gcc 57 Leu Ala gtc agg gga tgc tgt tcc cat cct gcc tgt get ggg aat aat cca cat 105 Val Arg Gly Cys Cys Ser His Pro Ala Cys Ala Gly Asn Asn Pro His atc tgt ggc aga aga cgc tq_atgctcca ggaccctctg aaccacgacg t 154 Ile Cys Gly Arg Arg Arg <210> 366 <211> 24 <212> PRT
<213> Conus omaria <400> 366 Leu Ala Val Arg Gly Cys Cys Ser His Pro Ala Cys Ala Gly Asn Asn Pro His Ile Cys Gly Arg Arg Arg <210> 367 <211> 142 <212> DNA
<213> Conus omaria <220>
<221> CDS
<222> (40)..(102) <400> 367 tctggtgtca ggaaagacgc agcgcctggc ctgatcgct ctg acc atc aag gga 54 Leu Thr Ile Lys Gly tgc tgt tct gat cct agc tgt aac gtg aat aat cca gac tat tgt ggt 102 Cys Cys Ser Asp Pro Ser Cys Asn Val Asn Asn Pro Asp Tyr Cys Gly tgacgacgct gatgctccag gaccctctga accacgacgt 142 <210> 368 <211> 21 <212> PRT
<213> Conus omaria <400> 368 Leu Thr Ile Lys Gly Cys Cys Ser Asp Pro Ser Cys Asn Val Asn Asn Pro Asp Tyr Cys Gly <210> 369 <211> 157 <212> DNA
<213> Conus omaria <220>
<221> CDS
<222> (52)..(117) <400> 369 tctaatggca ggaatgccgc agccaaattc aaagcgcct:g ccctgatgga g ctg acc 57 Leu Thr gtc agg gaa gaa tgc tgt tca gac cct cgc tgt tcc gtg gga cat caa 105 Val Arg Glu Glu Cys Cys Ser Asp Pro Arg Cys Ser Val Gly His Gln gat atg tgt cgg tgaagcacgl: gatgctccag gaccctctga accacgacgt 157 Asp Met Cys Arg <210> 370 <211> 22 <212> PRT
<213> Conus omaria <400> 370 Leu Thr Val Arg Glu Glu Cys Cys Ser Asp Pro Arg Cys Ser Val Gly His Gln Asp Met Cys Arg <210> 371 <211> 151 <212> DNA
<213> Conus purpurascens <220>
<221> CDS
<222> (1)..(120) <400> 371 act gat ggc agg aat get gca gcc ata gcg ctt gac ctg atc get ccg 48 Thr Asp Gly Arg Asn Ala Ala Ala Ile Ala Leu Asp Leu Ile Ala Pro gcc gtc agg gga gga tgc tgt tcc aat cct gcc tgt tta gtg aat cat 96 Ala Val Arg Gly Gly Cys Cys Ser Asn Pro Ala Cys Leu Val Asn His cta gaa atg tgt ggt aaa aga cgc tgatgcccca ggaccctctg aaccacgacg 150 Leu Glu Met Cys Gly Lys Arg Arg t 151 <210> 372 <211> 40 <212> PRT
<213> Conus purpurascens <400> 372 Thr Asp Gly Arg Asn Ala Ala Ala Ile Ala Levu Asp Leu Ile Ala Pro Ala Val Arg Gly Gly Cys Cys Ser Asn Pro Ala Cys Leu Val Asn His Leu Glu Met Cys Gly Lys Arg Arg <210> 373 <211> 160 <212> DNA
<213> Conus purpurascens <220>
<221> CDS
<222> (1)..(120) <400> 373 tct gat ggc agg gat gcc gca gcc aac gac aaa gcg tct gac ctg atc 48 Ser Asp Gly Arg Asp Ala Ala Ala Asn Asp Lys Ala Ser Asp Leu Ile get ctg acc gcc agg aga gat cca tgc tgt ttc aat cct gcc tgt aac 96 Ala Leu Thr Ala Arg Arg Asp Pro Cys Cys Phe Asn Pro Ala Cys Asn gtg aat aat cca cag att tat, ggt tgaagacgct gatgctccag gaccctctga 150 Val Asn Asn Pro Gln Ile Cys Gly accacgacgt 160 <210> 374 <211> 40 <212> PRT
<213> Conus purpurascens <400> 374 Ser Asp Gly Arg Asp Ala Ala Ala Asn Asp Lys Ala Ser Asp Leu Ile Ala Leu Thr Ala Arg Arg Asp Pro Cys Cys Phe Asn Pro Ala Cys Asn Val Asn Asn Pro Gln Ile Cys Gly <210> 375 <211> 151 <212> DNA
<213> Conus purpurascens <220>
<221> CDS
<222> (1)..(120) <400> 375 tct gat ggc agg gat get gag aaa aca ggc ttt gac acg acc att gtg 48 Ser Asp Gly Arg Asp Ala Glu Lys Thr Gly Phe Asp Thr Thr Ile Val ccg gaa gac tgc tgt tcg gat cct tcc tgt tgg agg ctg cat agt tta 96 Pro Glu Asp Cys Cys Ser Asp Pro Ser Cys Trp Arg Leu His Ser Leu get tgt act gga att gta aac cgc tgatgctcca ggaccctctg aaccacgacg 150 Ala Cys Thr Gly Ile Val Asn Arg t 151 <210> 376 <211> 40 <212> PRT
<213> Conus purpurascens <400> 376 Ser Asp Gly Arg Asp Ala Glu Lys Thr Gly Phe Asp Thr Thr Ile Val Pro Glu Asp Cys Cys Ser Asp Pro Ser Cys Trp Arg Leu His Ser Leu Ala Cys Thr Gly Ile Val Asn Arg <210> 377 <211> 142 <212> DNA
<213> Conus purpurascens <220>
<221> CDS
<222> (1)..(111) <400> 377 act gat ggc agg agt get gca gcc ata gcg ttt gcc ctg atc get ccg 48 Thr Asp Gly Arg Ser Ala Ala Ala Ile Ala Phe Ala Leu Ile Ala Pro acc gtc tgc tgt act aat cct gcc tgt ctc gtg aat aat ata cgc ttt 96 Thr Val Cys Cys Thr Asn Pro Ala Cys Leu Val Asn Asn Ile Arg Phe tgt ggt gga aga cgc tgatgcccca ggaccctctg aaccacgacg t 142 Cys Gly Gly Arg Arg <210> 378 <211> 37 <212> PRT

<213> Conus purpurascens <400> 378 Thr Asp Gly Arg Ser Ala Ala Ala Ile Ala Phe Ala Leu Ile Ala Pro Thr Val Cys Cys Thr Asn Pro Ala Cys Leu Val Asn Asn Ile Arg Phe Cys Gly Gly Arg Arg <210> 379 <211> 157 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(117) <400> 379 tct gat gga aga aat gcc gca agc gac gcc aaa gcg ttt ccc cgg atc 48 Ser Asp Gly Arg Asn Ala Ala Ser Asp Ala Lys Ala Phe Pro Arg Ile get cca atc gtc agg gac gaa tgc tgt agc gat cct agg tgt cac ggg 96 Ala Pro Ile Val Arg Asp Glu Cys Cys Ser Asp Pro Arg Cys His Gly aat aat cgg gac cac tgt get tgaagacgct gctgctccag gaccctctga 147 Asn Asn Arg Asp His Cys Ala accacgacgt 157 <210> 380 <211> 39 <212> PRT
<213> Conus regius <400> 380 Ser Asp Gly Arg Asn Ala Ala Ser Asp Ala Lys Ala Phe Pro Arg Ile Ala Pro Ile Val Arg Asp Glu Cys Cys Ser Asp Pro Arg Cys His Gly Asn Asn Arg Asp His Cys Ala <210> 381 :54 <211> 156 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(117) <400> 381 tct gat ggc agg aat acc gcg gcc gac gaa aaa gcg tcc gac ctg atc 48 Ser Asp Gly Arg Asn Thr Ala Ala Asp Glu Lys Ala Ser Asp Leu Ile tct caa act gtc aag aga gat tgc tgt tcc cat cct ctc tgt aga tta 96 Ser Gln Thr Val Lys Arg Asp Cys Cys Ser His Pro Leu Cys Arg Leu ttt gtt cca gga ctt tgt att tgaagacgct gctgctccag gaccctctga 147 Phe Val Pro Gly Leu Cys Ile accacgact 156 <210> 382 <211> 39 <212> PRT
<213> Conus regius <400> 382 Ser Asp Gly Arg Asn Thr Ala Ala Asp Glu Lys Ala Ser Asp Leu Ile Ser Gln Thr Val Lys Arg Asp Cys Cys Ser His Pro Leu Cys Arg Leu Phe Val Pro Gly Leu Cys Ile <210> 383 <211> 157 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1).. (117) <400> 383 tct gat ggc agg aat gcc gca gcc gac aac aaa gcg tct gac cta atc 48 Ser Asp Gly Arg Asn Ala Ala Ala Asp Asn Lys Ala Ser Asp Leu Ile get caa atc gtc agg aga gga tgc tgt tcc cat cct gtc tgt aaa gtg 96 Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Val Cys Lys Val agg tat cca gac ctg tgt cgt tgaagacgct gctgctccag gaccctctga 147 Arg Tyr Pro Asp Leu Cys Arg accacgacgt 157 <210> 384 <211> 39 <212> PRT
<213> Conus regius <400> 384 Ser Asp Gly Arg Asn Ala Ala Ala Asp Asn Lys Ala Ser Asp Leu Ile Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Val Cys Lys Val Arg Tyr Pro Asp Leu Cys Arg <210> 385 <211> 157 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(117) <400> 385 tct gat ggc agg aat gcc gca gcc gac aac aga gcg tct gac cta atc 48 Ser Asp Gly Arg Asn Ala Ala Ala Asp Asn Arg Ala Ser Asp Leu Ile get caa atc gtc agg aga gga tgc tgt tcc cat cct gcc tgt aat gtg 96 Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Ala Cys Asn Val aat aat cca cac att tgt ggt tgaagacgct gctgctccag gaccctctga 147 Asn Asn Pro His Ile Cys Gly accacgacgt 157 <210> 386 <211> 39 <212> PRT
<213> Conus regius <400> 386 Ser Asp Gly Arg Asn Ala Ala Ala Asp Asn Arg Ala Ser Asp Leu Ile Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Ala Cys Asn Val Asn Asn Pro His Ile Cys Gly <210> 387 <211> 157 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(117) <400> 387 tct gat ggc agg aat gcc gca gcc gac aac aaa ccg tct gac cta atc 48 Ser Asp Gly Arg Asn Ala Ala Ala Asp Asn Lys Pro Ser Asp Leu Ile get caa atc gtc agg aga gga tgc tgt tcg cat cct gtc tgt aaa gtg 96 Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Val Cys Lys Val agg tat tca gac atg tgt ggt tgaagacgct gctgctccag gaccctctga 147 Arg Tyr Ser Asp Met Cys Gly accacgacgt 157 <210> 388 <211> 39 <212> PRT
<213> Conus regius <400> 388 Ser Asp Gly Arg Asn Ala Ala Ala Asp Asn Lys Pro Ser Asp Leu Ile Ala Gln Ile Val Arg Arg Gly Cys Cys Ser His Pro Val Cys Lys Val Arg Tyr Ser Asp Met Cys Gly <210> 389 <211> 154 <212> DNA

<213> Conus stercusmuscarum <220>
<221> CDS
<222> (1)..(114) <400> 389 tct gat ggc agg aat gca gag cga cga caa agc gtc tgt cct ggt cgc 48 Ser Asp Gly Arg Asn Ala Glu Arg Arg Gln Ser Val Cys Pro Gly Arg tct ggc ccc agg gga gga tgt tgt tcc cac cct gcc tgt aag gtg cat 96 Ser Gly Pro Arg Gly Gly Cys Cys Ser His Pro Ala Cys Lys Val His ttt cca cac agt tgt ggt tcgacgacgct gatgctccag gaccctctga 144 Phe Pro His Ser Cys Gly accacgacgt 154 <210> 390 <211> 38 <212> PRT
<213> Conus stercusmuscarum <400> 390 Ser Asp Gly Arg Asn Ala Glu Arg Arg Gln Ser Val Cys Pro Gly Arg Ser Gly Pro Arg Gly Gly Cys Cys Ser His Pro Ala Cys Lys Val His Phe Pro His Ser Cys Gly <210> 391 <211> 145 <212> DNA
<213> Conus stercusmuscarum <220>
<221> CDS
<222> (1).,(114) <400> 391 tct gat ggc agg aat gcc gca gcc agc gac aga gcg tct gac gcg gcc 48 Ser Asp Gly Arg Asn Ala Ala Ala Ser Asp Arg Ala Ser Asp Ala Ala cac cag gta tgc tgt tcc aac cct gtc tgt cac gtg gat cat cca gaa 96 His Gin Val Cys Cys Ser Asn Pro Val Cys His Val Asp His Pro Glu ctt tgt cgt aga aga cgc tgatgctcca ggaccctctg aaccacgacg t 145 Leu Cys Arg Arg Arg Arg <210> 392 <211> 38 <212> PRT
<213> Conus stercusmuscarum <400> 392 Ser Asp Gly Arg Asn Ala Ala Ala Ser Asp Arg Ala Ser Asp Ala Ala His Gln Val Cys Cys Ser Asn Pro Val Cys His Val Asp His Pro Glu Leu Cys Arg Arg Arg Arg <210> 393 <211> 154 <212> DNA
<213> Conus striatus <220>
<221> CDS
<222> (1)..(123) <400> 393 tct gat ggc agg aat gcc gcg gcc aac gac aaa gcg tct gac ctg gtc 48 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Leu Val get ccg gcc atc agg gga tgc tgt tcc cac cct gtc tgt aac ttg agt 96 Ala Pro Ala Ile Arg Gly Cys Cys Ser His Pro Val Cys Asn Leu Ser aat cca caa att tgt cgt gga aga cgc tgatgctcca ggaccctctg 143 Asn Pro Gln Ile Cys Arg Gly Arg Arg aaccacgacg t 154 <210> 394 <211> 41 <212> PRT
<213> Conus striatus <400> 394 Ser Asp Gly Arg Asn Ala Ala Ala Asn Asp Lys Ala Ser Asp Leu Val Ala Pro Ala Ile Arg Gly Cys Cys Ser His Pro Val Cys Asn Leu Ser Asn Pro Gln Ile Cys Arg Gly Arg Arg <210> 395 <211> 117 <212> DNA
<213> Conus textile <220>
<221> CDS
<222> (1)..(114) <400> 395 ttt cat ggc agg aat gcc gca gcc aaa gcg tct ggc ctg gtc ggt ctg 48 Phe His Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Gly Leu acc gac aag agg caa gaa tgc tgt tct cat cct gcc tgt aac gta gat 96 Thr Asp Lys Arg Gln Glu Cys Cys Ser His Pro Ala Cys Asn Val Asp cat cca gaa att tgt cgt tga 117 His Pro Glu Ile Cys Arg <210> 396 <211> 38 <212> PRT
<213> Conus textile <400> 396 Phe His Gly Arg Asn Ala Ala Ala Lys Ala Ser Gly Leu Val Gly Leu Thr Asp Lys Arg Gln Glu Cys Cys Ser His Pro Ala Cys Asn Val Asp His Pro Glu Ile Cys Arg <210> 397 <211> 151 <212> DNA
<213> Conus tulipa <220>
<221> CDS
<222> (1) .. (120) <400> 397 act gat ggc agg agt get gca gcc ata gcg ttt gcc ctg atc get ccg 48 Thr Asp Gly Arg Ser Ala Ala Ala Ile Ala Phe Ala Leu Ile Ala Pro acc gtc tgg gaa gga tgc tgt tct aat cct gcc tgt ctc gtg aat cat 96 Thr Val Trp Glu Gly Cys Cys Ser Asn Pro Ala Cys Leu Val Asn His ata cgc ttt tgt ggt gga aga cgc tgatgcccca ggaccctctg aaccacgacg 150 Ile Arg Phe Cys Gly Gly Arg Arg t 151 <210> 398 <211> 40 <212> PRT
<213> Conus tulipa <400> 398 Thr Asp Gly Arg Ser Ala Ala Ala Ile Ala Phe Ala Leu Ile Ala Pro Thr Val Trp Glu Gly Cys Cys Ser Asn Pro Ala Cys Leu Val Asn His Ile Arg Phe Cys Gly Gly Arg Arg <210> 399 <211> 157 <212> DNA
<213> Conus virgo <220>
<221> CDS
<222> (1)..(117) <400> 399 tct aat ggc atg aat gcc gca gcc atc agg aaa gcg tct gcc ctg gtg 48 Ser Asn Gly Met Asn Ala Ala Ala Ile Arg Lys Ala Ser Ala Leu Val get cag atc gcc cat cga gac tgc tgt gac gat cct gcc tgc acc gtg 96 Ala Gln Ile Ala His Arg Asp Cys Cys Asp Asp Pro Ala Cys Thr Val aat aat cca ggc ctt tgc act tgaagatgct gctgccccag gaccctctga 147 Asn Asn Pro Gly Leu Cys Thr accacgacgt 157 <210> 400 <211> 39 <212> PRT
<213> Conus virgo <400> 400 Ser Asn Gly Met Asn Ala Ala Ala Ile Arg Lys Ala Ser Ala Leu Val Ala Gln Ile Ala His Arg Asp Cys Cys Asp Asp Pro Ala Cys Thr Val Asn Asn Pro Gly Leu Cys Thr <210> 401 <211> 154 <212> DNA
<213> Conus geographus <220>
<221> CDS
<222> (1)..(114) <400> 401 tct gat ggc ggg aat gcc gca gca aaa gag tct gac gtg atc get ctg 48 Ser Asp Gly Gly Asn Ala Ala Ala Lys Glu Ser Asp Val Ile Ala Leu 1 5 1.0 15 acc gtc tgg aaa tgc tgt acc att cct tcc tgt tat gag aaa aaa aaa 96 Thr Val Trp Lys Cys Cys Thr Ile Pro Ser C'ys Tyr Glu Lys Lys Lys att aaa gca tgt gtc ttt tgacgacgct gatgctccag gaccctctga 144 Ile Lys Ala Cys Val Phe accacgacgt 154 <210> 402 <211> 38 <212> PRT
<213> Conus geographus <400> 402 Ser Asp Gly Gly Asn Ala. Ala Ala Lys Glu Ser Asp Val Ile Ala Leu Thr Val Trp Lys Cys Cys Thr Ile Pro Ser Cys Tyr Glu Lys Lys Lys Ile Lys Ala Cys Val Phe <210> 403 <211> 154 <212> DNA
<213> Conus regius <220>
<221> CDS
<222> (1)..(114) <400> 403 tct gat ggc gca gtc gac gac aaa gcg ttg gat cga atc get gaa atc 48 Ser Asp Gly Ala Val Asp Asp Lys Ala Leu Asp Arg Ile Ala Glu Ile gtc agg aga gga tgc tgt ggc aat cct gcc tgt agc ggc tcc tcg aaa 96 Val Arg Arg Gly Cys Cys Gly Asn Pro Ala Cys Ser Gly Ser Ser Lys gat gca ccc tct tgt ggt tgaagacgat gctgctccag gaccctctga 144 Asp Ala Pro Ser Cys Gly accacgacgt 154 <210> 404 <211> 38 <212> PRT
<213> Conus regius <400> 404 Ser Asp Gly Ala Val Asp Asp Lys Ala Leu Asp Arg Ile Ala Glu Ile 1 5 1.0 15 Val Arg Arg Gly Cys Cys Gly Asn Pro Ala Cys Ser Gly Ser Ser Lys Asp Ala Pro Ser Cys Gly

Claims (9)

WHAT IS CLAIMED IS:

1. An isolated .alpha.-conotoxin peptide consisting of the amino acid sequence Gly-Cys-Cys-Ser-Asp-Xaa5-Arg-Cys-Arg-Xaa4-Arg-Cys-Arg (SEQ ID NO:9), wherein Xaa4 is Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr or nitro-Tyr, and Xaa5 is Pro or hydroxy-Pro, and the C-terminus contains a carboxyl or amide group.

2. The isolated .alpha.-conotoxin peptide of claim 1, wherein Xaa4 is Tyr.

3. The isolated .alpha.-conotoxin peptide of claim 1, wherein Xaa4 is mono-iodo-Tyr or di-iodo-Tyr.

4. The isolated .alpha.-conotoxin peptide of claim 1, wherein Xaa5 is Pro.

5. The isolated .alpha.-conotoxin peptide of claim 1, wherein Xaa5 is hydroxy-Pro.

6. The isolated .alpha.-conotoxin peptide of claim 1, wherein Xaa4 is Tyr and Xaa5 is Pro.

7. The isolated .alpha.-conotoxin peptide of claim 6, wherein the C-terminus contains an amide group.

8. The isolated .alpha.-conotoxin peptide of any one of claims 1-7 which is modified to contain an O-glycan, an S-glycan or an N-glycan.

9. An isolated precursor of the .alpha.-conotoxin peptide of claim 1, wherein the precursor consists of the amino acid sequence SNKRKNAAMLDMIAQHAIRGCCSDPRCRY
RCR (SEQ ID NO:244).