CA2290748A1 - Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4 - Google Patents

Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4 Download PDF

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Publication number
CA2290748A1
CA2290748A1 CA002290748A CA2290748A CA2290748A1 CA 2290748 A1 CA2290748 A1 CA 2290748A1 CA 002290748 A CA002290748 A CA 002290748A CA 2290748 A CA2290748 A CA 2290748A CA 2290748 A1 CA2290748 A1 CA 2290748A1
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CA
Canada
Prior art keywords
substituted
alkyl
heterocyclic
sulfonyl
toluene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002290748A
Other languages
English (en)
Inventor
Eugene D. Thorsett
Christopher M. Semko
Michael A. Pleiss
Anthony Kreft
Andrei W. Konradi
Francine S. Grant
Reinhardt Bernhard Baudy
Dimitrios Sarantakis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Elan Pharmaceuticals LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2290748A1 publication Critical patent/CA2290748A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Cette invention concerne des composés qui se lient à l'intégrine VLA-4. Certains de ces composés inhibent également l'adhésion des leucocytes et, en particulier, l'adhésion des leucocytes induite par la VLA-4. Ces composés sont utilisés pour traiter des maladies inflammatoires chez un patient mammifère, par exemple, un être humain. Parmi ces maladies, on trouve l'asthme, la maladie d'Alzheimer, l'athérosclérose, le complexe démentiel du SIDA, le diabète, l'affection intestinale inflammatoire, la polyarthrite rhumatoïde, la transplantation de tissus, la métastase tumorale et l'ischémie myocardique. Ces composés peuvent également être administrés pour traiter des maladies cérébrales inflammatoires telles que la sclérose en plaques.
CA002290748A 1997-07-31 1998-07-31 Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4 Abandoned CA2290748A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90442397A 1997-07-31 1997-07-31
US08/904,423 1997-07-31
PCT/US1998/016070 WO1999006437A1 (fr) 1997-07-31 1998-07-31 Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4

Publications (1)

Publication Number Publication Date
CA2290748A1 true CA2290748A1 (fr) 1999-02-11

Family

ID=25419137

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002290748A Abandoned CA2290748A1 (fr) 1997-07-31 1998-07-31 Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4

Country Status (12)

Country Link
EP (1) EP0994896A1 (fr)
JP (1) JP2001512139A (fr)
KR (1) KR20010022405A (fr)
CN (1) CN1265672A (fr)
AU (1) AU8823498A (fr)
BR (1) BR9811594A (fr)
CA (1) CA2290748A1 (fr)
HU (1) HUP0003921A3 (fr)
IL (1) IL133637A0 (fr)
NO (1) NO20000452L (fr)
PL (1) PL338457A1 (fr)
WO (1) WO1999006437A1 (fr)

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US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
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GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
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US6630503B1 (en) * 1999-08-13 2003-10-07 Biogen, Inc. Cell adhesion inhibitors
US6534513B1 (en) 1999-09-29 2003-03-18 Celltech R&D Limited Phenylalkanoic acid derivatives
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
CZ20022072A3 (cs) 1999-12-28 2003-05-14 Pfizer Products Inc. Nepeptidylové inhibitory VLA-4 dependentní buněčné vazby použitelné pro léčbu zánětlivých, autoimunitních a respiračních onemocnění
AU2001262089A1 (en) * 2000-03-14 2001-09-24 Novartis Ag Alpha4beta1 and alpha4beta7 integrin inhibitors
EP1332132B1 (fr) 2000-04-17 2007-10-10 UCB Pharma, S.A. Derives d'enamine comme molecules d'adhesion cellulaire
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
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WO2002004426A1 (fr) 2000-07-07 2002-01-17 Celltech R & D Limited Derives d'acide squarique contenant un noyau heteroaromatique bicyclique comme antagonistes d'integrine
AU2001275724A1 (en) 2000-08-02 2002-02-13 Celltech R&D Limited 3-substituted isoquinolin-1-yl derivatives
SK287781B6 (sk) 2000-08-18 2011-09-05 Ajinomoto Co., Inc. Fenylalanínové deriváty, farmaceutický prípravok s ich obsahom a ich použitie
MY129000A (en) 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
US6607735B2 (en) 2000-12-21 2003-08-19 Johnson & Johnson Consumer Companies, Inc. Method for reducing the appearance of dark circles under the eyes
JP2004526733A (ja) 2001-03-20 2004-09-02 メルク　エンド　カムパニー　インコーポレーテッド 強力な細胞接着阻害剤としての置換ｎ−アリールスルホニル−プロリン誘導体
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Also Published As

Publication number Publication date
IL133637A0 (en) 2001-04-30
KR20010022405A (ko) 2001-03-15
WO1999006437A1 (fr) 1999-02-11
JP2001512139A (ja) 2001-08-21
NO20000452L (no) 2000-03-27
PL338457A1 (en) 2000-11-06
CN1265672A (zh) 2000-09-06
AU8823498A (en) 1999-02-22
NO20000452D0 (no) 2000-01-28
HUP0003921A3 (en) 2001-03-28
BR9811594A (pt) 2000-09-05
HUP0003921A2 (hu) 2001-02-28
EP0994896A1 (fr) 2000-04-26

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Legal Events

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FZDE Discontinued