CA2251596A1 - Procede de preparation d'acide clavulanique - Google Patents

Procede de preparation d'acide clavulanique Download PDF

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Publication number
CA2251596A1
CA2251596A1 CA002251596A CA2251596A CA2251596A1 CA 2251596 A1 CA2251596 A1 CA 2251596A1 CA 002251596 A CA002251596 A CA 002251596A CA 2251596 A CA2251596 A CA 2251596A CA 2251596 A1 CA2251596 A1 CA 2251596A1
Authority
CA
Canada
Prior art keywords
assimilable
fermentation
phosphorus
source
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002251596A
Other languages
English (en)
Inventor
Artur Racman
Sasa Kranjc
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2251596A1 publication Critical patent/CA2251596A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention a pour objet un procédé de préparation d'acide clavulanique, qui comprend la fermentation d'une espèce de Streptomyces produisant de l'acide clavulanique dans un bouillon de fermentation contenant des sources assimilables de carbone et d'azote, la concentration de phosphore dans ledit bouillon de fermentation étant inférieure à 0,15 % en poids par volume.
CA002251596A 1996-04-12 1997-04-11 Procede de preparation d'acide clavulanique Abandoned CA2251596A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9600120A SI9600120A (en) 1996-04-12 1996-04-12 New and improved fermentative procedure for the production of clavulanic acid and its salts
SIP-9600120 1996-04-12

Publications (1)

Publication Number Publication Date
CA2251596A1 true CA2251596A1 (fr) 1997-10-23

Family

ID=20431824

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002251596A Abandoned CA2251596A1 (fr) 1996-04-12 1997-04-11 Procede de preparation d'acide clavulanique

Country Status (9)

Country Link
EP (1) EP0906446A1 (fr)
JP (1) JP2001503244A (fr)
AU (1) AU2516497A (fr)
CA (1) CA2251596A1 (fr)
PL (1) PL185620B1 (fr)
RU (1) RU2188868C2 (fr)
SI (1) SI9600120A (fr)
WO (1) WO1997039137A1 (fr)
ZA (1) ZA973139B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2101658B1 (es) * 1995-11-23 1998-03-01 Antibioticos Sa Nuevo procedimiento de produccion de acido clavulanico y sus sales.
AR015825A1 (es) * 1997-05-28 2001-05-30 Gist Brocades Bv Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato
US6440708B1 (en) * 1998-09-29 2002-08-27 Dsm N.V. Fermentation of clavulanic acid at a controlled level of ammonia
EP1117820A1 (fr) * 1998-09-29 2001-07-25 Dsm N.V. Fermentation d'acide clavulanique a un niveau regule d'ammoniac
EP2589663A1 (fr) 2011-11-04 2013-05-08 LEK Pharmaceuticals d.d. Procédé de production d'acide clavulanique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
JPS604720B2 (ja) * 1976-02-06 1985-02-06 ビ−チャム・グル−プ・ピ−エルシ− 醗酵方法
AR245221A1 (es) * 1984-10-27 1993-12-30 Beecham Group Plc Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus

Also Published As

Publication number Publication date
PL185620B1 (pl) 2003-06-30
ZA973139B (en) 1998-08-05
AU2516497A (en) 1997-11-07
JP2001503244A (ja) 2001-03-13
SI9600120A (en) 1997-12-31
EP0906446A1 (fr) 1999-04-07
RU2188868C2 (ru) 2002-09-10
PL329291A1 (en) 1999-03-15
WO1997039137A1 (fr) 1997-10-23

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